FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1355, 282 aa 1>>>pF1KE1355 282 - 282 aa - 282 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9800+/-0.000853; mu= 16.2474+/- 0.052 mean_var=54.2118+/-10.745, 0's: 0 Z-trim(104.3): 16 B-trim: 0 in 0/50 Lambda= 0.174192 statistics sampled from 7837 (7845) to 7837 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.624), E-opt: 0.2 (0.241), width: 16 Scan time: 2.310 The best scores are: opt bits E(32554) CCDS10507.1 DNASE1 gene_id:1773|Hs108|chr16 ( 282) 1875 479.2 1.4e-135 CCDS2886.1 DNASE1L3 gene_id:1776|Hs108|chr3 ( 305) 795 207.8 7.7e-54 CCDS14747.1 DNASE1L1 gene_id:1774|Hs108|chrX ( 302) 626 165.4 4.6e-41 CCDS42105.1 DNASE1L2 gene_id:1775|Hs108|chr16 ( 299) 556 147.8 9.1e-36 CCDS58836.1 DNASE1L3 gene_id:1776|Hs108|chr3 ( 275) 547 145.5 4.1e-35 >>CCDS10507.1 DNASE1 gene_id:1773|Hs108|chr16 (282 aa) initn: 1875 init1: 1875 opt: 1875 Z-score: 2547.4 bits: 479.2 E(32554): 1.4e-135 Smith-Waterman score: 1875; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:1-282) 10 20 30 40 50 60 pF1KE1 MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 EVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 EVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 DGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 DGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 GLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAG 190 200 210 220 230 240 250 260 270 280 pF1KE1 MLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK :::::::::::::::::::::::::::::::::::::::::: CCDS10 MLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK 250 260 270 280 >>CCDS2886.1 DNASE1L3 gene_id:1776|Hs108|chr3 (305 aa) initn: 678 init1: 364 opt: 795 Z-score: 1080.1 bits: 207.8 E(32554): 7.7e-54 Smith-Waterman score: 795; 44.8% identity (72.4% similar) in 279 aa overlap (7-282:5-282) 10 20 30 40 50 60 pF1KE1 MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQ :. :: : ...:....: .::...:::.:. . . .. ::....: :: ::. CCDS28 MSRELAPLLLLLLSIHSALAMRICSFNVRSFGESKQEDKNAMDVIVKVIKRCDIILVM 10 20 30 40 50 70 80 90 100 110 pF1KE1 EVRDSHLTAVGKLLDNLNQDAPD--TYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYY :..::. :...::... ::.::.: ::::.:::.: :.:. ::. ::. CCDS28 EIKDSNNRICPILMEKLNRNSRRGITYNYVISSRLGRNTYKEQYAFLYKEKLVSVKRSYH 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 YDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQE : : . :.:.::: .: : : : :..:.:.:::..: .: ::: : .:: ::.. CCDS28 YHDY-QDGDADVFSREPFVVWFQSPHTAVKDFVIIPLHTTPETSVKEIDELVEVYTDVKH 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 KWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATP-THCAYDRIV .: :. ..::::::::::: . :..::: :.: : ::: :. :::. :.::::::: CCDS28 RWKAENFIFMGDFNAGCSYVPKKAWKNIRLRTDPRFVWLIGDQEDTTVKKSTNCAYDRIV 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 VAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK . :. . ..::: : :.:: :: :... : .:::.::: :. CCDS28 LRGQEIVSSVVPKSNSVFDFQKAYKLTEEEALDVSDHFPVEFKLQSSRAFTNSKKSVTLR 240 250 260 270 280 290 CCDS28 KKTKSKRS 300 >>CCDS14747.1 DNASE1L1 gene_id:1774|Hs108|chrX (302 aa) initn: 562 init1: 275 opt: 626 Z-score: 850.6 bits: 165.4 E(32554): 4.6e-41 Smith-Waterman score: 626; 39.1% identity (68.8% similar) in 276 aa overlap (9-282:6-273) 10 20 30 40 50 60 pF1KE1 MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQ ::: : : .:: ...: ::: : . .:.. ... .:.::.: :: ..: CCDS14 MHYPTALLFLI-LANGAQAFRICAFNAQRLTLAKVAREQVMDTLVRILARCDIMVLQ 10 20 30 40 50 70 80 90 100 110 pF1KE1 EVRDSHLTAVGKLLDNLNQ-DAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYY :: :: .:. :: .::. :. : . : :::..: : :.. :: ......:: : CCDS14 EVVDSSGSAIPLLLRELNRFDGSGPYSTLSSPQLGRSTYMETYVYFYRSHKTQVLSSYVY 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 DDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEK .: .:.: ::: ...: . . ...::::..: . :..:::::.:.:... CCDS14 NDE-----DDVFAREPFVAQFSLPSNVLPSLVLVPLHTTPKAVEKELNALYDVFLEVSQH 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 WGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTA-TPTHCAYDRIVV : .::.:.::::: :. . .. ....: : : :.:.: :. :::. . :::.:::.:. CCDS14 WQSKDVILLGDFNADCASLTKKRLDKLELRTEPGFHWVIADGEDTTVRASTHCTYDRVVL 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 AGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK : :. . .: :.: ... :... : ::::::::: :: CCDS14 HGERCRSLL--HTAAAFDFPTSFQLTEEEALNISDHYPVEVELKLSQAHSVQPLSLTVLL 240 250 260 270 280 CCDS14 LLSLLSPQLCPAA 290 300 >>CCDS42105.1 DNASE1L2 gene_id:1775|Hs108|chr16 (299 aa) initn: 898 init1: 556 opt: 556 Z-score: 755.6 bits: 147.8 E(32554): 9.1e-36 Smith-Waterman score: 916; 51.2% identity (73.4% similar) in 297 aa overlap (6-282:7-296) 10 20 30 40 50 pF1KE1 MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALV ::.:: :: : :...:.:.:::::.::..:.:. . : :..::. ::.::: CCDS42 MGGPRALLAALWALEA--AGTAALRIGAFNIQSFGDSKVSDPACGSIIAKILAGYDLALV 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 QEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYY ::::: :.::. :....:. . : .: :.::::..::: :::::: : ::.::.: : CCDS42 QEVRDPDLSAVSALMEQINSVSEHEYSFVSSQPLGRDQYKEMYLFVYRKDAVSVVDTYLY 60 70 80 90 100 110 120 130 140 150 pF1KE1 DDGCEPCGNDTFNREPAIVRFFSRFTEVR--------------------EFAIVPLHAAP : : .:.:.::: .:.: . : : .....:::::: CCDS42 PD---P--EDVFSREPFVVKFSAPGTGERAPPLPSRRALTPPPLPAAAQNLVLIPLHAAP 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE1 GDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIP .::::::::::::::: .::: .:....::::: ::::: ..:..::: .: .:.:::: CCDS42 HQAVAEIDALYDVYLDVIDKWGTDDMLFLGDFNADCSYVRAQDWAAIRLRSSEVFKWLIP 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE1 DSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEV ::::::. . :::::::. : :: .. :.:: .:: .::.. : :::::.:::: CCDS42 DSADTTVGNSDCAYDRIVACGARLRRSLKPQSATVHDFQEEFGLDQTQALAISDHFPVEV 240 250 260 270 280 290 280 pF1KE1 MLK :: CCDS42 TLKFHR >>CCDS58836.1 DNASE1L3 gene_id:1776|Hs108|chr3 (275 aa) initn: 694 init1: 364 opt: 547 Z-score: 744.0 bits: 145.5 E(32554): 4.1e-35 Smith-Waterman score: 644; 40.1% identity (65.3% similar) in 277 aa overlap (7-282:5-252) 10 20 30 40 50 60 pF1KE1 MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQ :. :: : ...:....: .::...:::.:. . . .. ::....: :: ::. CCDS58 MSRELAPLLLLLLSIHSALAMRICSFNVRSFGESKQEDKNAMDVIVKVIKRCDIILVM 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 EVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYD :..::. :...:: .:. . : : ::.: CCDS58 EIKDSNNRICPILMEKLN--------------------REKLVSVKR--------SYHYH 60 70 80 90 130 140 150 160 170 180 pF1KE1 DGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKW : . :.:.::: .: : : : :..:.:.:::..: .: ::: : .:: ::...: CCDS58 DY-QDGDADVFSREPFVVWFQSPHTAVKDFVIIPLHTTPETSVKEIDELVEVYTDVKHRW 100 110 120 130 140 190 200 210 220 230 pF1KE1 GLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATP-THCAYDRIVVA :. ..::::::::::: . :..::: :.: : ::: :. :::. :.:::::::. CCDS58 KAENFIFMGDFNAGCSYVPKKAWKNIRLRTDPRFVWLIGDQEDTTVKKSTNCAYDRIVLR 150 160 170 180 190 200 240 250 260 270 280 pF1KE1 GMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK :. . ..::: : :.:: :: :... : .:::.::: :. CCDS58 GQEIVSSVVPKSNSVFDFQKAYKLTEEEALDVSDHFPVEFKLQSSRAFTNSKKSVTLRKK 210 220 230 240 250 260 CCDS58 TKSKRS 270 282 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 22:31:13 2016 done: Sun Nov 6 22:31:13 2016 Total Scan time: 2.310 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]