Result of FASTA (omim) for
pF1KE1360
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1360, 239 aa
1>>>pF1KE1360 239 - 239 aa - 239 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7678+/-0.000304; mu= 12.9740+/- 0.019
mean_var=76.2017+/-15.172, 0's: 0 Z-trim(117.5): 10 B-trim: 149 in 2/49
Lambda= 0.146924
statistics sampled from 29621 (29631) to 29621 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.347), width: 16
Scan time: 5.110
The best scores are: opt bits E(85289)
NP_002809 (OMIM: 602161) proteasome activator comp ( 239) 1550 337.3 1.5e-92
XP_006720276 (OMIM: 602161) PREDICTED: proteasome ( 162) 1034 227.8 8.8e-60
NP_006254 (OMIM: 600654) proteasome activator comp ( 249) 559 127.2 2.6e-29
NP_001268458 (OMIM: 600654) proteasome activator c ( 236) 521 119.1 6.5e-27
NP_001268457 (OMIM: 600654) proteasome activator c ( 233) 486 111.7 1.1e-24
NP_788955 (OMIM: 600654) proteasome activator comp ( 250) 481 110.7 2.5e-24
NP_005780 (OMIM: 605129) proteasome activator comp ( 254) 424 98.6 1.1e-20
NP_001253974 (OMIM: 605129) proteasome activator c ( 265) 424 98.6 1.1e-20
NP_001317158 (OMIM: 605129) proteasome activator c ( 193) 397 92.8 4.5e-19
NP_789839 (OMIM: 605129) proteasome activator comp ( 267) 310 74.4 2.1e-13
>>NP_002809 (OMIM: 602161) proteasome activator complex (239 aa)
initn: 1550 init1: 1550 opt: 1550 Z-score: 1782.8 bits: 337.3 E(85289): 1.5e-92
Smith-Waterman score: 1550; 99.6% identity (99.6% similar) in 239 aa overlap (1-239:1-239)
10 20 30 40 50 60
pF1KE1 MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 RAPLDIPIPDPPPKDDEMETDKQEKKEVPKCGFLPGNEKVLSLLALVKPEVWTLKEKCIL
:::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
NP_002 RAPLDIPIPDPPPKDDEMETDKQEKKEVHKCGFLPGNEKVLSLLALVKPEVWTLKEKCIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 VITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASK
130 140 150 160 170 180
190 200 210 220 230
pF1KE1 ETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY
190 200 210 220 230
>>XP_006720276 (OMIM: 602161) PREDICTED: proteasome acti (162 aa)
initn: 1034 init1: 1034 opt: 1034 Z-score: 1194.3 bits: 227.8 E(85289): 8.8e-60
Smith-Waterman score: 1034; 99.4% identity (99.4% similar) in 162 aa overlap (78-239:1-162)
50 60 70 80 90 100
pF1KE1 QEDSLNVADLTSLRAPLDIPIPDPPPKDDEMETDKQEKKEVPKCGFLPGNEKVLSLLALV
::::::::::: ::::::::::::::::::
XP_006 METDKQEKKEVHKCGFLPGNEKVLSLLALV
10 20 30
110 120 130 140 150 160
pF1KE1 KPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKY
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE1 FSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKI
100 110 120 130 140 150
230
pF1KE1 VNPKGEEKPSMY
::::::::::::
XP_006 VNPKGEEKPSMY
160
>>NP_006254 (OMIM: 600654) proteasome activator complex (249 aa)
initn: 763 init1: 536 opt: 559 Z-score: 647.3 bits: 127.2 E(85289): 2.6e-29
Smith-Waterman score: 746; 48.4% identity (74.0% similar) in 246 aa overlap (7-239:4-249)
10 20 30 40 50 60
pF1KE1 MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSL
.:.. ::. .:.:::..: ..:..: ..:.:: :. .:.: .:: :.:..:
NP_006 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNL
10 20 30 40 50
70 80 90 100
pF1KE1 RAPLDIPIPDPPPKDDEMETDKQEKKEV-------------PKCGFLPGNEKVLSLLALV
.::::::.::: . .. : ::..:: : :: . :::.. :: .
NP_006 KAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 KPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKY
:::. . :. :: ::.: ::.:::::.::::.::::.: .....::.:.:.: ::::
NP_006 KPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKY
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 FSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKI
::::::::.::.:. :: ::: :::: ::: : ..: ::...: :: :: :: .:.::.
NP_006 FSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKL
180 190 200 210 220 230
230
pF1KE1 VNPKGEEKPSMY
.:.:: : .:
NP_006 KKPRGETKGMIY
240
>>NP_001268458 (OMIM: 600654) proteasome activator compl (236 aa)
initn: 629 init1: 444 opt: 521 Z-score: 604.1 bits: 119.1 E(85289): 6.5e-27
Smith-Waterman score: 675; 45.9% identity (69.1% similar) in 246 aa overlap (7-239:4-236)
10 20 30 40 50 60
pF1KE1 MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSL
.:.. ::. .:.:::..: ..:..: ..:.:: :. .:.: .:: :.:..:
NP_001 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNL
10 20 30 40 50
70 80 90 100
pF1KE1 RAPLDIPIPDPPPKDDEMETDKQEKKEV-------------PKCGFLPGNEKVLSLLALV
.::::::.::: . .. : ::..:: : :: . :::.. :: .
NP_001 KAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 KPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKY
:::. . :. :: ::.: ::.:::::.::::.: .:.:.: ::::
NP_001 KPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQ-------------LEGFHTQISKY
120 130 140 150 160
170 180 190 200 210 220
pF1KE1 FSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKI
::::::::.::.:. :: ::: :::: ::: : ..: ::...: :: :: :: .:.::.
NP_001 FSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKL
170 180 190 200 210 220
230
pF1KE1 VNPKGEEKPSMY
.:.:: : .:
NP_001 KKPRGETKGMIY
230
>>NP_001268457 (OMIM: 600654) proteasome activator compl (233 aa)
initn: 685 init1: 458 opt: 486 Z-score: 564.1 bits: 111.7 E(85289): 1.1e-24
Smith-Waterman score: 673; 47.4% identity (73.9% similar) in 230 aa overlap (7-222:4-233)
10 20 30 40 50 60
pF1KE1 MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSL
.:.. ::. .:.:::..: ..:..: ..:.:: :. .:.: .:: :.:..:
NP_001 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNL
10 20 30 40 50
70 80 90 100
pF1KE1 RAPLDIPIPDPPPKDDEMETDKQEKKEV-------------PKCGFLPGNEKVLSLLALV
.::::::.::: . .. : ::..:: : :: . :::.. :: .
NP_001 KAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 KPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKY
:::. . :. :: ::.: ::.:::::.::::.::::.: .....::.:.:.: ::::
NP_001 KPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKY
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 FSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLR-AFYAELYHIISSNLEK
::::::::.::.:. :: ::: :::: ::: : ..: ::...: :. .: .. ::
NP_001 FSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYVRRLCYMTSS
180 190 200 210 220 230
230
pF1KE1 IVNPKGEEKPSMY
>>NP_788955 (OMIM: 600654) proteasome activator complex (250 aa)
initn: 685 init1: 458 opt: 481 Z-score: 557.9 bits: 110.7 E(85289): 2.5e-24
Smith-Waterman score: 668; 48.2% identity (74.1% similar) in 220 aa overlap (7-213:4-223)
10 20 30 40 50 60
pF1KE1 MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSL
.:.. ::. .:.:::..: ..:..: ..:.:: :. .:.: .:: :.:..:
NP_788 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNL
10 20 30 40 50
70 80 90 100
pF1KE1 RAPLDIPIPDPPPKDDEMETDKQEKKEV-------------PKCGFLPGNEKVLSLLALV
.::::::.::: . .. : ::..:: : :: . :::.. :: .
NP_788 KAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 KPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKY
:::. . :. :: ::.: ::.:::::.::::.::::.: .....::.:.:.: ::::
NP_788 KPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKY
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 FSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKI
::::::::.::.:. :: ::: :::: ::: : ..: ::...: :
NP_788 FSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYVRRQGQGRGGQRQL
180 190 200 210 220 230
230
pF1KE1 VNPKGEEKPSMY
NP_788 SQATHSLTLQARG
240 250
>>NP_005780 (OMIM: 605129) proteasome activator complex (254 aa)
initn: 580 init1: 397 opt: 424 Z-score: 492.5 bits: 98.6 E(85289): 1.1e-20
Smith-Waterman score: 535; 33.6% identity (66.8% similar) in 250 aa overlap (7-239:5-254)
10 20 30 40 50 60
pF1KE1 MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSL
.... :.. .:. ::. . .:::... :.:.:.. :...:.: ::. :::..
NP_005 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQI
10 20 30 40 50
70 80 90 100
pF1KE1 RAPLDIPIPDP---PPKDDEMETDKQEKKEVPKC--------------GFLPGNEKVLSL
.. ...:.::: . : .. .:... .: :.: .:......
NP_005 HSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDI
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 LALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTT
. ::::. : ::: : :.: :::.:::::.:::.:::... .. .:.... ..
NP_005 IEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQ
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 ISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSN
::.:. :. :.: .: :: ::: : : :: : :: .. .:: :. :. .: .:
NP_005 ISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKN
180 190 200 210 220 230
230
pF1KE1 LEKIVNPKGEEKPSMY
.::: :.. . ..:
NP_005 IEKIKRPRSSNAETLY
240 250
>>NP_001253974 (OMIM: 605129) proteasome activator compl (265 aa)
initn: 571 init1: 397 opt: 424 Z-score: 492.2 bits: 98.6 E(85289): 1.1e-20
Smith-Waterman score: 526; 34.4% identity (66.4% similar) in 241 aa overlap (16-239:25-265)
10 20 30 40 50
pF1KE1 MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDS
.:. ::. . .:::... :.:.:.. :...:.:
NP_001 MEKWILKKIKYLQSGGLSASYYSYKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPI
10 20 30 40 50 60
60 70 80 90
pF1KE1 LNVADLTSLRAPLDIPIPDP---PPKDDEMETDKQEKKEVPKC--------------GFL
::. :::.... ...:.::: . : .. .:... .: :.:
NP_001 LNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGML
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE1 PGNEKVLSLLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVK
.:....... ::::. : ::: : :.: :::.:::::.:::.:::... .. .:.
NP_001 KSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVE
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE1 TKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYA
... .. ::.:. :. :.: .: :: ::: : : :: : :: .. .:: :.
NP_001 SEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYV
190 200 210 220 230 240
220 230
pF1KE1 ELYHIISSNLEKIVNPKGEEKPSMY
:. .: .:.::: :.. . ..:
NP_001 TLHDMILKNIEKIKRPRSSNAETLY
250 260
>>NP_001317158 (OMIM: 605129) proteasome activator compl (193 aa)
initn: 450 init1: 397 opt: 397 Z-score: 463.4 bits: 92.8 E(85289): 4.5e-19
Smith-Waterman score: 405; 34.2% identity (63.2% similar) in 193 aa overlap (64-239:1-193)
40 50 60 70 80 90
pF1KE1 RFLPQKIIYLNQLLQEDSLNVADLTSLRAPLDIPIPDP---PPKDDEMETDKQEKKEVPK
...:.::: . : .. .:... .
NP_001 MNLPVPDPILLTNSHDGLDGPTYKKRRLDE
10 20 30
100 110 120 130
pF1KE1 C--------------GFLPGNEKVLSLLALVKPEVWTLKEKCILVITWIQHLIPKIEDGN
: :.: .:....... ::::. : ::: : :.: :::.:::::
NP_001 CEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGN
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE1 DFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDE
.:::.:::... .. .:.... .. ::.:. :. :.: .: :: ::: : : ::
NP_001 NFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDE
100 110 120 130 140 150
200 210 220 230
pF1KE1 AAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY
: :: .. .:: :. :. .: .:.::: :.. . ..:
NP_001 KEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY
160 170 180 190
>>NP_789839 (OMIM: 605129) proteasome activator complex (267 aa)
initn: 469 init1: 286 opt: 310 Z-score: 361.6 bits: 74.4 E(85289): 2.1e-13
Smith-Waterman score: 503; 31.9% identity (63.9% similar) in 263 aa overlap (7-239:5-267)
10 20 30 40 50 60
pF1KE1 MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSL
.... :.. .:. ::. . .:::... :.:.:.. :...:.: ::. :::..
NP_789 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQI
10 20 30 40 50
70 80 90 100
pF1KE1 RAPLDIPIPDP---PPKDDEMETDKQEKKEVPKC--------------GFLPGNEKVLSL
.. ...:.::: . : .. .:... .: :.: .:......
NP_789 HSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDI
60 70 80 90 100 110
110 120 130 140 150
pF1KE1 LALVKPEVWTLKEKC-------------ILVITWIQHLIPKIEDGNDFGVAIQEKVLERV
. ::::. : ::: . : :.: :::.:::::.:::.:::... ..
NP_789 IEKVKPEIRLLIEKCNTPSGKGPHICFDLQVKMWVQLLIPRIEDGNNFGVSIQEETVAEL
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE1 NAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLR
.:.... .. ::.:. :. :.: .: :: ::: : : :: : :: .. .::
NP_789 RTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELR
180 190 200 210 220 230
220 230
pF1KE1 AFYAELYHIISSNLEKIVNPKGEEKPSMY
:. :. .: .:.::: :.. . ..:
NP_789 NQYVTLHDMILKNIEKIKRPRSSNAETLY
240 250 260
239 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 02:28:23 2016 done: Mon Nov 7 02:28:24 2016
Total Scan time: 5.110 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]