FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1394, 522 aa 1>>>pF1KE1394 522 - 522 aa - 522 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4636+/-0.00038; mu= 15.5223+/- 0.024 mean_var=153.9286+/-31.391, 0's: 0 Z-trim(117.8): 25 B-trim: 320 in 2/53 Lambda= 0.103375 statistics sampled from 30085 (30108) to 30085 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.694), E-opt: 0.2 (0.353), width: 16 Scan time: 10.410 The best scores are: opt bits E(85289) NP_001192183 (OMIM: 251290,602876) occludin isofor ( 522) 3526 537.9 2.8e-152 NP_002529 (OMIM: 251290,602876) occludin isoform a ( 522) 3526 537.9 2.8e-152 NP_001192184 (OMIM: 251290,602876) occludin isofor ( 271) 1822 283.5 5.6e-76 XP_016864402 (OMIM: 251290,602876) PREDICTED: occl ( 468) 1685 263.3 1.2e-69 XP_016864403 (OMIM: 251290,602876) PREDICTED: occl ( 468) 1685 263.3 1.2e-69 XP_016882826 (OMIM: 600284) PREDICTED: RNA polymer ( 337) 247 48.7 3.3e-05 XP_016882825 (OMIM: 600284) PREDICTED: RNA polymer ( 370) 247 48.7 3.6e-05 XP_016882824 (OMIM: 600284) PREDICTED: RNA polymer ( 488) 247 48.8 4.3e-05 NP_006523 (OMIM: 600284) RNA polymerase II elongat ( 621) 247 49.0 5e-05 XP_016864732 (OMIM: 601874) PREDICTED: RNA polymer ( 455) 232 46.6 0.00019 XP_016864729 (OMIM: 601874) PREDICTED: RNA polymer ( 508) 232 46.6 0.00021 XP_016864730 (OMIM: 601874) PREDICTED: RNA polymer ( 508) 232 46.6 0.00021 XP_016864731 (OMIM: 601874) PREDICTED: RNA polymer ( 508) 232 46.6 0.00021 XP_006714638 (OMIM: 601874) PREDICTED: RNA polymer ( 585) 232 46.7 0.00023 NP_036213 (OMIM: 601874) RNA polymerase II elongat ( 640) 232 46.7 0.00024 XP_005248504 (OMIM: 610153,610572) PREDICTED: MARV ( 546) 213 43.8 0.0016 NP_001231663 (OMIM: 610153,610572) MARVEL domain-c ( 546) 213 43.8 0.0016 XP_005248502 (OMIM: 610153,610572) PREDICTED: MARV ( 558) 213 43.8 0.0016 XP_005248503 (OMIM: 610153,610572) PREDICTED: MARV ( 558) 213 43.8 0.0016 NP_001033692 (OMIM: 610153,610572) MARVEL domain-c ( 558) 213 43.8 0.0016 >>NP_001192183 (OMIM: 251290,602876) occludin isoform a (522 aa) initn: 3526 init1: 3526 opt: 3526 Z-score: 2855.0 bits: 537.9 E(85289): 2.8e-152 Smith-Waterman score: 3526; 99.8% identity (99.8% similar) in 522 aa overlap (1-522:1-522) 10 20 30 40 50 60 pF1KE1 MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTSLLGGSVGYPYGGSGFGSYGSGYGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTSLLGGSVGYPYGGSGFGSYGSGYGY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYSYHYCVVD :::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::: NP_001 ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 VSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPESSYKSTPVPEVVQELPLTSPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPESSYKSTPVPEVVQELPLTSPV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 DDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYETDYTTGGESCDELEEDWIREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYETDYTTGGESCDELEEDWIREY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 PPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAADE 430 440 450 460 470 480 490 500 510 520 pF1KE1 YNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQKT :::::::::::::::::::::::::::::::::::::::::: NP_001 YNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQKT 490 500 510 520 >>NP_002529 (OMIM: 251290,602876) occludin isoform a [Ho (522 aa) initn: 3526 init1: 3526 opt: 3526 Z-score: 2855.0 bits: 537.9 E(85289): 2.8e-152 Smith-Waterman score: 3526; 99.8% identity (99.8% similar) in 522 aa overlap (1-522:1-522) 10 20 30 40 50 60 pF1KE1 MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTSLLGGSVGYPYGGSGFGSYGSGYGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTSLLGGSVGYPYGGSGFGSYGSGYGY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYSYHYCVVD :::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::: NP_002 ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 VSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPESSYKSTPVPEVVQELPLTSPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPESSYKSTPVPEVVQELPLTSPV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 DDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYETDYTTGGESCDELEEDWIREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYETDYTTGGESCDELEEDWIREY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 PPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAADE 430 440 450 460 470 480 490 500 510 520 pF1KE1 YNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQKT :::::::::::::::::::::::::::::::::::::::::: NP_002 YNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQKT 490 500 510 520 >>NP_001192184 (OMIM: 251290,602876) occludin isoform b (271 aa) initn: 1822 init1: 1822 opt: 1822 Z-score: 1485.0 bits: 283.5 E(85289): 5.6e-76 Smith-Waterman score: 1822; 100.0% identity (100.0% similar) in 271 aa overlap (252-522:1-271) 230 240 250 260 270 280 pF1KE1 PAATGLYVDQYSYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNILW :::::::::::::::::::::::::::::: NP_001 MIIVAFALIIFFAVKTRRKMDRYDKSNILW 10 20 30 290 300 310 320 330 340 pF1KE1 DKEHIYDEQPPNVEEWVKNVSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPESS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKEHIYDEQPPNVEEWVKNVSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPESS 40 50 60 70 80 90 350 360 370 380 390 400 pF1KE1 YKSTPVPEVVQELPLTSPVDDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYETD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YKSTPVPEVVQELPLTSPVDDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYETD 100 110 120 130 140 150 410 420 430 440 450 460 pF1KE1 YTTGGESCDELEEDWIREYPPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTTGGESCDELEEDWIREYPPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLD 160 170 180 190 200 210 470 480 490 500 510 520 pF1KE1 KELDDYREESEEYMAAADEYNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KELDDYREESEEYMAAADEYNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQK 220 230 240 250 260 270 pF1KE1 T : NP_001 T >>XP_016864402 (OMIM: 251290,602876) PREDICTED: occludin (468 aa) initn: 1662 init1: 1662 opt: 1685 Z-score: 1371.7 bits: 263.3 E(85289): 1.2e-69 Smith-Waterman score: 3046; 89.5% identity (89.5% similar) in 522 aa overlap (1-522:1-468) 10 20 30 40 50 60 pF1KE1 MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTSLLGGSVGYPYGGSGFGSYGSGYGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTSLLGGSVGYPYGGSGFGSYGSGYGY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYSYHYCVVD :::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::: XP_016 ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKN ::: ::: XP_016 PQE------------------------------------------------------VKN 310 320 330 340 350 360 pF1KE1 VSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPESSYKSTPVPEVVQELPLTSPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPESSYKSTPVPEVVQELPLTSPV 250 260 270 280 290 300 370 380 390 400 410 420 pF1KE1 DDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYETDYTTGGESCDELEEDWIREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYETDYTTGGESCDELEEDWIREY 310 320 330 340 350 360 430 440 450 460 470 480 pF1KE1 PPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAADE 370 380 390 400 410 420 490 500 510 520 pF1KE1 YNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQKT :::::::::::::::::::::::::::::::::::::::::: XP_016 YNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQKT 430 440 450 460 >>XP_016864403 (OMIM: 251290,602876) PREDICTED: occludin (468 aa) initn: 1662 init1: 1662 opt: 1685 Z-score: 1371.7 bits: 263.3 E(85289): 1.2e-69 Smith-Waterman score: 3046; 89.5% identity (89.5% similar) in 522 aa overlap (1-522:1-468) 10 20 30 40 50 60 pF1KE1 MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTSLLGGSVGYPYGGSGFGSYGSGYGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTSLLGGSVGYPYGGSGFGSYGSGYGY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYSYHYCVVD :::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::: XP_016 ILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKN ::: ::: XP_016 PQE------------------------------------------------------VKN 310 320 330 340 350 360 pF1KE1 VSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPESSYKSTPVPEVVQELPLTSPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPESSYKSTPVPEVVQELPLTSPV 250 260 270 280 290 300 370 380 390 400 410 420 pF1KE1 DDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYETDYTTGGESCDELEEDWIREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYETDYTTGGESCDELEEDWIREY 310 320 330 340 350 360 430 440 450 460 470 480 pF1KE1 PPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAADE 370 380 390 400 410 420 490 500 510 520 pF1KE1 YNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQKT :::::::::::::::::::::::::::::::::::::::::: XP_016 YNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQKT 430 440 450 460 >>XP_016882826 (OMIM: 600284) PREDICTED: RNA polymerase (337 aa) initn: 255 init1: 148 opt: 247 Z-score: 214.4 bits: 48.7 E(85289): 3.3e-05 Smith-Waterman score: 282; 28.1% identity (59.6% similar) in 235 aa overlap (311-521:101-332) 290 300 310 320 330 340 pF1KE1 WDKEHIYDEQPPNVEEWVKNVSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPES :: :. .:.: :: .. : : XP_016 KLGVPNGREALLPTPGPPASTDTLSSSTHLPPRLEPPRAHDPLADVSNDLGHSGR-DCEH 80 90 100 110 120 350 360 370 380 390 pF1KE1 SYKSTPVPEVVQELPLTSPVDDFRQPRYS-SGGNFETPSKRAPAKGRAGRSKRTEQ--DH . ..:.: : ::: . . .:. : : .. . ::. : ::...: : : XP_016 GEAAAPAPTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERAAEDKPRAQLPDC 130 140 150 160 170 180 400 410 420 430 440 pF1KE1 YETDYTTGGESCDE-----------------LEEDWIREYPPITSDQQRQLYKRNFDTGL . ..: : : :.. .: :.:..::: :: .:.. XP_016 APATHATPGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEY 190 200 210 220 230 240 450 460 470 480 490 pF1KE1 QEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAA----DEYNRLKQVKGSADYKSK .::..:......:......:: .: . . :::: .. .:: ..: : ...:... XP_016 SEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKIK--KTNTNYSQE 250 260 270 280 290 300 500 510 520 pF1KE1 KNHCKQLKSKLSHIKKMVGDYDRQKT :..:. :.:::.:::.....::... XP_016 KHRCEYLHSKLAHIKRLIAEYDQRQLQAWP 310 320 330 >>XP_016882825 (OMIM: 600284) PREDICTED: RNA polymerase (370 aa) initn: 255 init1: 148 opt: 247 Z-score: 213.9 bits: 48.7 E(85289): 3.6e-05 Smith-Waterman score: 282; 28.1% identity (59.6% similar) in 235 aa overlap (311-521:134-365) 290 300 310 320 330 340 pF1KE1 WDKEHIYDEQPPNVEEWVKNVSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPES :: :. .:.: :: .. : : XP_016 KLGVPNGREALLPTPGPPASTDTLSSSTHLPPRLEPPRAHDPLADVSNDLGHSGR-DCEH 110 120 130 140 150 160 350 360 370 380 390 pF1KE1 SYKSTPVPEVVQELPLTSPVDDFRQPRYS-SGGNFETPSKRAPAKGRAGRSKRTEQ--DH . ..:.: : ::: . . .:. : : .. . ::. : ::...: : : XP_016 GEAAAPAPTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERAAEDKPRAQLPDC 170 180 190 200 210 220 400 410 420 430 440 pF1KE1 YETDYTTGGESCDE-----------------LEEDWIREYPPITSDQQRQLYKRNFDTGL . ..: : : :.. .: :.:..::: :: .:.. XP_016 APATHATPGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEY 230 240 250 260 270 280 450 460 470 480 490 pF1KE1 QEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAA----DEYNRLKQVKGSADYKSK .::..:......:......:: .: . . :::: .. .:: ..: : ...:... XP_016 SEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKIK--KTNTNYSQE 290 300 310 320 330 340 500 510 520 pF1KE1 KNHCKQLKSKLSHIKKMVGDYDRQKT :..:. :.:::.:::.....::... XP_016 KHRCEYLHSKLAHIKRLIAEYDQRQLQAWP 350 360 370 >>XP_016882824 (OMIM: 600284) PREDICTED: RNA polymerase (488 aa) initn: 255 init1: 148 opt: 247 Z-score: 212.4 bits: 48.8 E(85289): 4.3e-05 Smith-Waterman score: 282; 28.1% identity (59.6% similar) in 235 aa overlap (311-521:252-483) 290 300 310 320 330 340 pF1KE1 WDKEHIYDEQPPNVEEWVKNVSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPES :: :. .:.: :: .. : : XP_016 KLGVPNGREALLPTPGPPASTDTLSSSTHLPPRLEPPRAHDPLADVSNDLGHSGR-DCEH 230 240 250 260 270 280 350 360 370 380 390 pF1KE1 SYKSTPVPEVVQELPLTSPVDDFRQPRYS-SGGNFETPSKRAPAKGRAGRSKRTEQ--DH . ..:.: : ::: . . .:. : : .. . ::. : ::...: : : XP_016 GEAAAPAPTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERAAEDKPRAQLPDC 290 300 310 320 330 340 400 410 420 430 440 pF1KE1 YETDYTTGGESCDE-----------------LEEDWIREYPPITSDQQRQLYKRNFDTGL . ..: : : :.. .: :.:..::: :: .:.. XP_016 APATHATPGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEY 350 360 370 380 390 400 450 460 470 480 490 pF1KE1 QEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAA----DEYNRLKQVKGSADYKSK .::..:......:......:: .: . . :::: .. .:: ..: : ...:... XP_016 SEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKIK--KTNTNYSQE 410 420 430 440 450 500 510 520 pF1KE1 KNHCKQLKSKLSHIKKMVGDYDRQKT :..:. :.:::.:::.....::... XP_016 KHRCEYLHSKLAHIKRLIAEYDQRQLQAWP 460 470 480 >>NP_006523 (OMIM: 600284) RNA polymerase II elongation (621 aa) initn: 230 init1: 148 opt: 247 Z-score: 211.2 bits: 49.0 E(85289): 5e-05 Smith-Waterman score: 282; 28.1% identity (59.6% similar) in 235 aa overlap (311-521:385-616) 290 300 310 320 330 340 pF1KE1 WDKEHIYDEQPPNVEEWVKNVSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPES :: :. .:.: :: .. : : NP_006 KLGVPNGREALLPTPGPPASTDTLSSSTHLPPRLEPPRAHDPLADVSNDLGHSGR-DCEH 360 370 380 390 400 410 350 360 370 380 390 pF1KE1 SYKSTPVPEVVQELPLTSPVDDFRQPRYS-SGGNFETPSKRAPAKGRAGRSKRTEQ--DH . ..:.: : ::: . . .:. : : .. . ::. : ::...: : : NP_006 GEAAAPAPTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERAAEDKPRAQLPDC 420 430 440 450 460 470 400 410 420 430 440 pF1KE1 YETDYTTGGESCDE-----------------LEEDWIREYPPITSDQQRQLYKRNFDTGL . ..: : : :.. .: :.:..::: :: .:.. NP_006 APATHATPGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEY 480 490 500 510 520 530 450 460 470 480 490 pF1KE1 QEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAA----DEYNRLKQVKGSADYKSK .::..:......:......:: .: . . :::: .. .:: ..: : ...:... NP_006 SEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKIK--KTNTNYSQE 540 550 560 570 580 590 500 510 520 pF1KE1 KNHCKQLKSKLSHIKKMVGDYDRQKT :..:. :.:::.:::.....::... NP_006 KHRCEYLHSKLAHIKRLIAEYDQRQLQAWP 600 610 620 >>XP_016864732 (OMIM: 601874) PREDICTED: RNA polymerase (455 aa) initn: 238 init1: 100 opt: 232 Z-score: 200.7 bits: 46.6 E(85289): 0.00019 Smith-Waterman score: 232; 29.6% identity (65.1% similar) in 152 aa overlap (375-521:302-450) 350 360 370 380 390 400 pF1KE1 TPVPEVVQELPLTSPVDDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYETDYTT : :: .. . :. . . . : :. XP_016 MSHKKSKKKSKKHKEKDQIKKHDIETIEEKEEDLKREEEIAKLNNSSPNSSGGVKEDCTA 280 290 300 310 320 330 410 420 430 440 450 460 pF1KE1 GGE-SCDELEEDWIREYPPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLDKE . : : :: :.. .: :.: .::: :: .:.. .::..:..... . ... .:: . XP_016 SMEPSAIELP-DYLIKYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQ 340 350 360 370 380 390 470 480 490 500 510 pF1KE1 LDDYREESEEYMAAADE----YNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDR :.::. . .: :...:: .: .:. .: .:. :..::.:::...:..:. XP_016 RKRLSPGSKEYQNVHEEVLQEYQKIKQ--SSPNYHEEKYRCEYLHNKLAHIKRLIGEFDQ 400 410 420 430 440 520 pF1KE1 QKT :. XP_016 QQAESWS 450 522 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 19:22:49 2016 done: Sat Nov 5 19:22:50 2016 Total Scan time: 10.410 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]