FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1444, 274 aa 1>>>pF1KE1444 274 - 274 aa - 274 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9789+/-0.000376; mu= 16.5613+/- 0.023 mean_var=60.3645+/-12.449, 0's: 0 Z-trim(111.7): 28 B-trim: 80 in 1/54 Lambda= 0.165076 statistics sampled from 20336 (20356) to 20336 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.616), E-opt: 0.2 (0.239), width: 16 Scan time: 6.710 The best scores are: opt bits E(85289) NP_000894 (OMIM: 125860) NAD(P)H dehydrogenase [qu ( 274) 1833 445.0 6.9e-125 NP_001020605 (OMIM: 125860) NAD(P)H dehydrogenase ( 236) 933 230.7 2e-60 NP_001020604 (OMIM: 125860) NAD(P)H dehydrogenase ( 240) 926 229.0 6.5e-60 NP_000895 (OMIM: 114480,160998) ribosyldihydronico ( 231) 736 183.7 2.6e-46 NP_001277150 (OMIM: 114480,160998) ribosyldihydron ( 231) 736 183.7 2.6e-46 NP_001305869 (OMIM: 114480,160998) ribosyldihydron ( 231) 736 183.7 2.6e-46 NP_001273066 (OMIM: 125860) NAD(P)H dehydrogenase ( 202) 696 174.2 1.7e-43 NP_001277151 (OMIM: 114480,160998) ribosyldihydron ( 193) 309 82.0 9.4e-16 >>NP_000894 (OMIM: 125860) NAD(P)H dehydrogenase [quinon (274 aa) initn: 1833 init1: 1833 opt: 1833 Z-score: 2363.1 bits: 445.0 E(85289): 6.9e-125 Smith-Waterman score: 1833; 100.0% identity (100.0% similar) in 274 aa overlap (1-274:1-274) 10 20 30 40 50 60 pF1KE1 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK 190 200 210 220 230 240 250 260 270 pF1KE1 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK :::::::::::::::::::::::::::::::::: NP_000 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 250 260 270 >>NP_001020605 (OMIM: 125860) NAD(P)H dehydrogenase [qui (236 aa) initn: 921 init1: 921 opt: 933 Z-score: 1205.7 bits: 230.7 E(85289): 2e-60 Smith-Waterman score: 1468; 86.1% identity (86.1% similar) in 274 aa overlap (1-274:1-236) 10 20 30 40 50 60 pF1KE1 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV ::::::::::::::::::::::::::::::::::::::::: NP_001 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQ------------------- 70 80 90 100 130 140 150 160 170 180 pF1KE1 FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC ::::::::::::::::::::::::::::::::::::::::: NP_001 -------------------SKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC 110 120 130 140 190 200 210 220 230 240 pF1KE1 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK 150 160 170 180 190 200 250 260 270 pF1KE1 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK :::::::::::::::::::::::::::::::::: NP_001 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 210 220 230 >>NP_001020604 (OMIM: 125860) NAD(P)H dehydrogenase [qui (240 aa) initn: 926 init1: 926 opt: 926 Z-score: 1196.6 bits: 229.0 E(85289): 6.5e-60 Smith-Waterman score: 1532; 87.6% identity (87.6% similar) in 274 aa overlap (1-274:1-240) 10 20 30 40 50 60 pF1KE1 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC :::::::::::::::::::: :::::: NP_001 FIGEFAYTYAAMYDKGPFRS----------------------------------GILHFC 130 140 190 200 210 220 230 240 pF1KE1 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK 150 160 170 180 190 200 250 260 270 pF1KE1 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK :::::::::::::::::::::::::::::::::: NP_001 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 210 220 230 240 >>NP_000895 (OMIM: 114480,160998) ribosyldihydronicotina (231 aa) initn: 740 init1: 715 opt: 736 Z-score: 952.3 bits: 183.7 E(85289): 2.6e-46 Smith-Waterman score: 736; 48.4% identity (76.5% similar) in 221 aa overlap (1-221:1-221) 10 20 30 40 50 60 pF1KE1 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL :.:...::: ::.: ::: ..:..:. :...: :. :::::::..: . ::::: : NP_000 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV ..: :.: .:. :::. :. ::. ::::.. :::::::::: ::.::::::::..:: NP_000 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC . ::. ..::.: ...: :.::.::::.. ::. :..:: .:::.: : :::: NP_000 LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK ::.:: ::.... . . : .. .:..::..:: : :. NP_000 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 190 200 210 220 230 250 260 270 pF1KE1 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK >>NP_001277150 (OMIM: 114480,160998) ribosyldihydronicot (231 aa) initn: 740 init1: 715 opt: 736 Z-score: 952.3 bits: 183.7 E(85289): 2.6e-46 Smith-Waterman score: 736; 48.4% identity (76.5% similar) in 221 aa overlap (1-221:1-221) 10 20 30 40 50 60 pF1KE1 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL :.:...::: ::.: ::: ..:..:. :...: :. :::::::..: . ::::: : NP_001 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV ..: :.: .:. :::. :. ::. ::::.. :::::::::: ::.::::::::..:: NP_001 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC . ::. ..::.: ...: :.::.::::.. ::. :..:: .:::.: : :::: NP_001 LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK ::.:: ::.... . . : .. .:..::..:: : :. NP_001 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 190 200 210 220 230 250 260 270 pF1KE1 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK >>NP_001305869 (OMIM: 114480,160998) ribosyldihydronicot (231 aa) initn: 740 init1: 715 opt: 736 Z-score: 952.3 bits: 183.7 E(85289): 2.6e-46 Smith-Waterman score: 736; 48.4% identity (76.5% similar) in 221 aa overlap (1-221:1-221) 10 20 30 40 50 60 pF1KE1 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL :.:...::: ::.: ::: ..:..:. :...: :. :::::::..: . ::::: : NP_001 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV ..: :.: .:. :::. :. ::. ::::.. :::::::::: ::.::::::::..:: NP_001 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC . ::. ..::.: ...: :.::.::::.. ::. :..:: .:::.: : :::: NP_001 LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK ::.:: ::.... . . : .. .:..::..:: : :. NP_001 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 190 200 210 220 230 250 260 270 pF1KE1 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK >>NP_001273066 (OMIM: 125860) NAD(P)H dehydrogenase [qui (202 aa) initn: 696 init1: 696 opt: 696 Z-score: 901.7 bits: 174.2 E(85289): 1.7e-43 Smith-Waterman score: 1177; 73.7% identity (73.7% similar) in 274 aa overlap (1-274:1-202) 10 20 30 40 50 60 pF1KE1 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV ::::::::::::::::::::::::::::::::::::::::: NP_001 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQ------------------- 70 80 90 100 130 140 150 160 170 180 pF1KE1 FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC ::::::: NP_001 -----------------------------------------------------SGILHFC 190 200 210 220 230 240 pF1KE1 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK 110 120 130 140 150 160 250 260 270 pF1KE1 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK :::::::::::::::::::::::::::::::::: NP_001 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 170 180 190 200 >>NP_001277151 (OMIM: 114480,160998) ribosyldihydronicot (193 aa) initn: 565 init1: 306 opt: 309 Z-score: 403.8 bits: 82.0 E(85289): 9.4e-16 Smith-Waterman score: 502; 39.4% identity (62.9% similar) in 221 aa overlap (1-221:1-183) 10 20 30 40 50 60 pF1KE1 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL :.:...::: ::.: ::: ..:..:. :...: :. :::::::..: . ::::: : NP_001 MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV ..: :.: .:. :::. :. ::. ::::.. ::::::: NP_001 SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQ------------------- 70 80 90 100 130 140 150 160 170 180 pF1KE1 FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC .: :.::.::::.. ::. :..:: .:::.: : :::: NP_001 -------------------GKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC 110 120 130 140 190 200 210 220 230 240 pF1KE1 GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK ::.:: ::.... . . : .. .:..::..:: : :. NP_001 GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 150 160 170 180 190 250 260 270 pF1KE1 KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 274 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 02:12:26 2016 done: Mon Nov 7 02:12:27 2016 Total Scan time: 6.710 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]