Result of FASTA (omim) for
pF1KE1598
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1598, 1432 aa
1>>>pF1KE1598 1432 - 1432 aa - 1432 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.7129+/-0.000546; mu= 10.9725+/- 0.034
mean_var=123.7324+/-24.676, 0's: 0 Z-trim(109.7): 145 B-trim: 34 in 1/49
Lambda= 0.115301
statistics sampled from 17829 (17977) to 17829 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.538), E-opt: 0.2 (0.211), width: 16
Scan time: 11.780
The best scores are: opt bits E(85289)
NP_000544 (OMIM: 277700,604611) Werner syndrome AT (1432) 9451 1585.0 0
XP_011542941 (OMIM: 277700,604611) PREDICTED: Wern (1405) 6510 1095.8 0
XP_011542942 (OMIM: 277700,604611) PREDICTED: Wern ( 899) 5665 955.2 0
XP_005253520 (OMIM: 600537) PREDICTED: ATP-depende ( 649) 841 152.7 8.7e-36
NP_116559 (OMIM: 600537) ATP-dependent DNA helicas ( 649) 841 152.7 8.7e-36
XP_005253519 (OMIM: 600537) PREDICTED: ATP-depende ( 649) 841 152.7 8.7e-36
XP_005253521 (OMIM: 600537) PREDICTED: ATP-depende ( 649) 841 152.7 8.7e-36
XP_005253518 (OMIM: 600537) PREDICTED: ATP-depende ( 649) 841 152.7 8.7e-36
NP_002898 (OMIM: 600537) ATP-dependent DNA helicas ( 649) 841 152.7 8.7e-36
XP_006720695 (OMIM: 210900,604610) PREDICTED: Bloo ( 763) 653 121.4 2.6e-26
XP_011520183 (OMIM: 210900,604610) PREDICTED: Bloo ( 979) 653 121.5 3.3e-26
NP_001274177 (OMIM: 210900,604610) Bloom syndrome (1042) 653 121.5 3.5e-26
NP_001274175 (OMIM: 210900,604610) Bloom syndrome (1417) 653 121.5 4.5e-26
NP_000048 (OMIM: 210900,604610) Bloom syndrome pro (1417) 653 121.5 4.5e-26
NP_001274176 (OMIM: 210900,604610) Bloom syndrome (1286) 640 119.3 1.9e-25
XP_005257880 (OMIM: 603781) PREDICTED: ATP-depende ( 549) 565 106.7 5e-22
XP_016880832 (OMIM: 603781) PREDICTED: ATP-depende ( 991) 567 107.2 6.7e-22
NP_004250 (OMIM: 603781) ATP-dependent DNA helicas ( 991) 567 107.2 6.7e-22
XP_005257875 (OMIM: 603781) PREDICTED: ATP-depende (1012) 567 107.2 6.8e-22
XP_011523784 (OMIM: 603781) PREDICTED: ATP-depende (1012) 567 107.2 6.8e-22
NP_001003716 (OMIM: 603781) ATP-dependent DNA heli ( 410) 547 103.7 3.1e-21
XP_016880833 (OMIM: 603781) PREDICTED: ATP-depende ( 435) 547 103.7 3.2e-21
NP_001003715 (OMIM: 603781) ATP-dependent DNA heli ( 435) 547 103.7 3.2e-21
XP_011515686 (OMIM: 218600,266280,268400,603780) P (1142) 353 71.6 3.9e-11
XP_016869488 (OMIM: 218600,266280,268400,603780) P (1224) 353 71.6 4.2e-11
XP_016869486 (OMIM: 218600,266280,268400,603780) P (1254) 353 71.6 4.3e-11
XP_016869489 (OMIM: 218600,266280,268400,603780) P ( 941) 290 61.1 4.7e-08
XP_016869487 (OMIM: 218600,266280,268400,603780) P (1238) 290 61.1 6.1e-08
XP_016869485 (OMIM: 218600,266280,268400,603780) P (1263) 290 61.1 6.2e-08
XP_016869483 (OMIM: 218600,266280,268400,603780) P (1288) 290 61.1 6.3e-08
XP_016869481 (OMIM: 218600,266280,268400,603780) P (1295) 290 61.1 6.3e-08
XP_016869480 (OMIM: 218600,266280,268400,603780) P (1320) 290 61.1 6.4e-08
XP_016869490 (OMIM: 218600,266280,268400,603780) P ( 911) 287 60.6 6.5e-08
NP_004251 (OMIM: 218600,266280,268400,603780) ATP- (1208) 287 60.6 8.4e-08
XP_016869484 (OMIM: 218600,266280,268400,603780) P (1265) 287 60.6 8.7e-08
XP_016869482 (OMIM: 218600,266280,268400,603780) P (1290) 287 60.6 8.9e-08
XP_011520184 (OMIM: 210900,604610) PREDICTED: Bloo ( 907) 262 56.4 1.2e-06
NP_001180292 (OMIM: 616940) exonuclease 3'-5' doma ( 621) 252 54.7 2.6e-06
NP_001180290 (OMIM: 616940) exonuclease 3'-5' doma ( 621) 252 54.7 2.6e-06
NP_001180289 (OMIM: 616940) exonuclease 3'-5' doma ( 621) 252 54.7 2.6e-06
NP_001180291 (OMIM: 616940) exonuclease 3'-5' doma ( 621) 252 54.7 2.6e-06
XP_016866492 (OMIM: 606286) PREDICTED: probable AT ( 439) 207 47.1 0.00035
XP_011534230 (OMIM: 606286) PREDICTED: probable AT ( 529) 207 47.2 0.00041
XP_011534229 (OMIM: 606286) PREDICTED: probable AT ( 529) 207 47.2 0.00041
NP_055555 (OMIM: 268305,608546) eukaryotic initiat ( 411) 205 46.8 0.00041
XP_011534228 (OMIM: 606286) PREDICTED: probable AT ( 604) 207 47.2 0.00046
NP_061135 (OMIM: 606286) probable ATP-dependent RN ( 648) 207 47.2 0.00049
XP_016884803 (OMIM: 300160,300958) PREDICTED: ATP- ( 475) 196 45.3 0.0013
XP_016884802 (OMIM: 300160,300958) PREDICTED: ATP- ( 476) 196 45.3 0.0013
XP_016876910 (OMIM: 616940) PREDICTED: exonuclease ( 496) 196 45.3 0.0014
>>NP_000544 (OMIM: 277700,604611) Werner syndrome ATP-de (1432 aa)
initn: 9451 init1: 9451 opt: 9451 Z-score: 8498.3 bits: 1585.0 E(85289): 0
Smith-Waterman score: 9451; 99.9% identity (99.9% similar) in 1432 aa overlap (1-1432:1-1432)
10 20 30 40 50 60
pF1KE1 MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDAS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHISSMSVF
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
NP_000 DCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 PQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAIN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 KEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMII
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 GSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 STEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 STEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 NLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLIS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 LMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 GITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQV
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 TGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 APKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 APKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKME
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 KYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 PQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSR
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 QLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 TVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE1 SQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKR
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE1 IDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMA
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE1 ITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVI
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE1 RNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSRDVNKRRCFPGSEE
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
NP_000 RNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430
pF1KE1 ICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS
1390 1400 1410 1420 1430
>>XP_011542941 (OMIM: 277700,604611) PREDICTED: Werner s (1405 aa)
initn: 6510 init1: 6510 opt: 6510 Z-score: 5854.5 bits: 1095.8 E(85289): 0
Smith-Waterman score: 9211; 98.0% identity (98.0% similar) in 1432 aa overlap (1-1432:1-1405)
10 20 30 40 50 60
pF1KE1 MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDAS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHISSMSVF
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
XP_011 DCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 PQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAIN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 KEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMII
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 GSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 STEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLE
:::::::::::::::::::::::::::::: :::
XP_011 STEHLSPNDNENDTSYVIESDEDLEMEMLK---------------------------SLE
430 440 450
490 500 510 520 530 540
pF1KE1 NLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE1 KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLIS
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE1 LMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADI
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE1 GITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE1 RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQV
700 710 720 730 740 750
790 800 810 820 830 840
pF1KE1 TGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYG
760 770 780 790 800 810
850 860 870 880 890 900
pF1KE1 APKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKME
820 830 840 850 860 870
910 920 930 940 950 960
pF1KE1 KYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFG
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KE1 PQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSR
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KE1 QLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSK
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KE1 TVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSS
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KE1 SQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKR
1120 1130 1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KE1 IDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMA
1180 1190 1200 1210 1220 1230
1270 1280 1290 1300 1310 1320
pF1KE1 ITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVI
1240 1250 1260 1270 1280 1290
1330 1340 1350 1360 1370 1380
pF1KE1 RNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSRDVNKRRCFPGSEE
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
XP_011 RNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEE
1300 1310 1320 1330 1340 1350
1390 1400 1410 1420 1430
pF1KE1 ICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS
1360 1370 1380 1390 1400
>>XP_011542942 (OMIM: 277700,604611) PREDICTED: Werner s (899 aa)
initn: 5664 init1: 5664 opt: 5665 Z-score: 5097.9 bits: 955.2 E(85289): 0
Smith-Waterman score: 5665; 98.2% identity (99.0% similar) in 877 aa overlap (557-1432:23-899)
530 540 550 560 570 580
pF1KE1 FLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATG-YGKSLCFQYPP
..: : : ..:. . . :::::::::::
XP_011 MMKMKLMKGKKMMIRTFCGQHPMKSKLLASRCTLAIPVLNRYGKSLCFQYPP
10 20 30 40 50
590 600 610 620 630 640
pF1KE1 VYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEY
60 70 80 90 100 110
650 660 670 680 690 700
pF1KE1 CSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTAT
120 130 140 150 160 170
710 720 730 740 750 760
pF1KE1 ASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEG
180 190 200 210 220 230
770 780 790 800 810 820
pF1KE1 PTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFG
240 250 260 270 280 290
830 840 850 860 870 880
pF1KE1 MGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRN
300 310 320 330 340 350
890 900 910 920 930 940
pF1KE1 EKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDH
360 370 380 390 400 410
950 960 970 980 990 1000
pF1KE1 CYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFG
420 430 440 450 460 470
1010 1020 1030 1040 1050 1060
pF1KE1 TGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQA
480 490 500 510 520 530
1070 1080 1090 1100 1110 1120
pF1KE1 NEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNIS
540 550 560 570 580 590
1130 1140 1150 1160 1170 1180
pF1KE1 KKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILV
600 610 620 630 640 650
1190 1200 1210 1220 1230 1240
pF1KE1 DMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTS
660 670 680 690 700 710
1250 1260 1270 1280 1290 1300
pF1KE1 LVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLER
720 730 740 750 760 770
1310 1320 1330 1340 1350 1360
pF1KE1 AGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQP
780 790 800 810 820 830
1370 1380 1390 1400 1410 1420
pF1KE1 SRDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKT
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKT
840 850 860 870 880 890
1430
pF1KE1 KRGGLFS
:::::::
XP_011 KRGGLFS
>>XP_005253520 (OMIM: 600537) PREDICTED: ATP-dependent D (649 aa)
initn: 841 init1: 343 opt: 841 Z-score: 763.4 bits: 152.7 E(85289): 8.7e-36
Smith-Waterman score: 855; 34.6% identity (64.0% similar) in 483 aa overlap (509-977:51-510)
480 490 500 510 520 530
pF1KE1 LENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEED----DDKDFLWPAPNE
:..: . .:: . . . .:: : . .
XP_005 VEIQIQELTERQQELIQKKKVLTKKIKQCLEDSDAGASNEYDSSPAAWNKEDFPWSGKVK
30 40 50 60 70 80
540 550 560 570 580 590
pF1KE1 EQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLV
. :. : .:.:.: ..:. : .. :: :: :::::.: : . . ::
XP_005 D---ILQNVFKLEKFRPLQLETIN-VTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLV
90 100 110 120 130
600 610 620 630 640
pF1KE1 ISPLISLMEDQVLQLKMSNIPACFLGSAQSEN----VLTDI--KLGKYRIVYVTPEYCSG
: :::::::::.. ::. .: : .:....:.. : ... : .. ...::::: .
XP_005 ICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAK
140 150 160 170 180 190
650 660 670 680 690 700
pF1KE1 NMGLLQQLEADIG---ITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTAT
. ....:: .: :::::.:: :.:::::: ... :: :: .: . ...::::
XP_005 SKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTAT
200 210 220 230 240 250
710 720 730 740 750 760
pF1KE1 ASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEG
:.. . : . : ... ..:.::::: :::.: .: .:. .:: . ...:
XP_005 ATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNT-EDFIEDIVKLING-RYKG
260 270 280 290 300 310
770 780 790 800 810 820
pF1KE1 PT-IIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAF
. :::: :.: ..::: :..:.. :.:::.. . .:... .::: :.::.::
XP_005 QSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAF
320 330 340 350 360 370
830 840 850 860 870 880
pF1KE1 GMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIR
::::.: :.: :::.. :.::.:::: :::::: ....: . .. .:: .. . .
XP_005 GMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDI---FRISSMVV
380 390 400 410 420 430
890 900 910 920 930 940
pF1KE1 NEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLD
:. :: :... . . :.::: .. .::.. ..: .: :::: . :
XP_005 MENVGQQKLYEMVSYCQNI--SKCRRVLMAQHFDEVWNSEAC------NKMCDNCCK--D
440 450 460 470 480
950 960 970 980 990 1000
pF1KE1 HCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLF
. . . :. .:.:. .. :.::.
XP_005 SAFERKNITEYCRDL----IKILKQAEELNEKLTPLKLIDSWMGKGAAKLRVAGVVAPTL
490 500 510 520 530
1010 1020 1030 1040 1050 1060
pF1KE1 GTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQ
XP_005 PREDLEKIIAHFLIQQYLKEDYSFTAYATISYLKIGPKANLLNNEAHAITMQVTKSTQNS
540 550 560 570 580 590
>>NP_116559 (OMIM: 600537) ATP-dependent DNA helicase Q1 (649 aa)
initn: 841 init1: 343 opt: 841 Z-score: 763.4 bits: 152.7 E(85289): 8.7e-36
Smith-Waterman score: 855; 34.6% identity (64.0% similar) in 483 aa overlap (509-977:51-510)
480 490 500 510 520 530
pF1KE1 LENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEED----DDKDFLWPAPNE
:..: . .:: . . . .:: : . .
NP_116 VEIQIQELTERQQELIQKKKVLTKKIKQCLEDSDAGASNEYDSSPAAWNKEDFPWSGKVK
30 40 50 60 70 80
540 550 560 570 580 590
pF1KE1 EQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLV
. :. : .:.:.: ..:. : .. :: :: :::::.: : . . ::
NP_116 D---ILQNVFKLEKFRPLQLETIN-VTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLV
90 100 110 120 130
600 610 620 630 640
pF1KE1 ISPLISLMEDQVLQLKMSNIPACFLGSAQSEN----VLTDI--KLGKYRIVYVTPEYCSG
: :::::::::.. ::. .: : .:....:.. : ... : .. ...::::: .
NP_116 ICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAK
140 150 160 170 180 190
650 660 670 680 690 700
pF1KE1 NMGLLQQLEADIG---ITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTAT
. ....:: .: :::::.:: :.:::::: ... :: :: .: . ...::::
NP_116 SKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTAT
200 210 220 230 240 250
710 720 730 740 750 760
pF1KE1 ASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEG
:.. . : . : ... ..:.::::: :::.: .: .:. .:: . ...:
NP_116 ATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNT-EDFIEDIVKLING-RYKG
260 270 280 290 300 310
770 780 790 800 810 820
pF1KE1 PT-IIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAF
. :::: :.: ..::: :..:.. :.:::.. . .:... .::: :.::.::
NP_116 QSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAF
320 330 340 350 360 370
830 840 850 860 870 880
pF1KE1 GMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIR
::::.: :.: :::.. :.::.:::: :::::: ....: . .. .:: .. . .
NP_116 GMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDI---FRISSMVV
380 390 400 410 420 430
890 900 910 920 930 940
pF1KE1 NEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLD
:. :: :... . . :.::: .. .::.. ..: .: :::: . :
NP_116 MENVGQQKLYEMVSYCQNI--SKCRRVLMAQHFDEVWNSEAC------NKMCDNCCK--D
440 450 460 470 480
950 960 970 980 990 1000
pF1KE1 HCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLF
. . . :. .:.:. .. :.::.
NP_116 SAFERKNITEYCRDL----IKILKQAEELNEKLTPLKLIDSWMGKGAAKLRVAGVVAPTL
490 500 510 520 530
1010 1020 1030 1040 1050 1060
pF1KE1 GTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQ
NP_116 PREDLEKIIAHFLIQQYLKEDYSFTAYATISYLKIGPKANLLNNEAHAITMQVTKSTQNS
540 550 560 570 580 590
>>XP_005253519 (OMIM: 600537) PREDICTED: ATP-dependent D (649 aa)
initn: 841 init1: 343 opt: 841 Z-score: 763.4 bits: 152.7 E(85289): 8.7e-36
Smith-Waterman score: 855; 34.6% identity (64.0% similar) in 483 aa overlap (509-977:51-510)
480 490 500 510 520 530
pF1KE1 LENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEED----DDKDFLWPAPNE
:..: . .:: . . . .:: : . .
XP_005 VEIQIQELTERQQELIQKKKVLTKKIKQCLEDSDAGASNEYDSSPAAWNKEDFPWSGKVK
30 40 50 60 70 80
540 550 560 570 580 590
pF1KE1 EQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLV
. :. : .:.:.: ..:. : .. :: :: :::::.: : . . ::
XP_005 D---ILQNVFKLEKFRPLQLETIN-VTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLV
90 100 110 120 130
600 610 620 630 640
pF1KE1 ISPLISLMEDQVLQLKMSNIPACFLGSAQSEN----VLTDI--KLGKYRIVYVTPEYCSG
: :::::::::.. ::. .: : .:....:.. : ... : .. ...::::: .
XP_005 ICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAK
140 150 160 170 180 190
650 660 670 680 690 700
pF1KE1 NMGLLQQLEADIG---ITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTAT
. ....:: .: :::::.:: :.:::::: ... :: :: .: . ...::::
XP_005 SKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTAT
200 210 220 230 240 250
710 720 730 740 750 760
pF1KE1 ASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEG
:.. . : . : ... ..:.::::: :::.: .: .:. .:: . ...:
XP_005 ATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNT-EDFIEDIVKLING-RYKG
260 270 280 290 300 310
770 780 790 800 810 820
pF1KE1 PT-IIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAF
. :::: :.: ..::: :..:.. :.:::.. . .:... .::: :.::.::
XP_005 QSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAF
320 330 340 350 360 370
830 840 850 860 870 880
pF1KE1 GMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIR
::::.: :.: :::.. :.::.:::: :::::: ....: . .. .:: .. . .
XP_005 GMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDI---FRISSMVV
380 390 400 410 420 430
890 900 910 920 930 940
pF1KE1 NEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLD
:. :: :... . . :.::: .. .::.. ..: .: :::: . :
XP_005 MENVGQQKLYEMVSYCQNI--SKCRRVLMAQHFDEVWNSEAC------NKMCDNCCK--D
440 450 460 470 480
950 960 970 980 990 1000
pF1KE1 HCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLF
. . . :. .:.:. .. :.::.
XP_005 SAFERKNITEYCRDL----IKILKQAEELNEKLTPLKLIDSWMGKGAAKLRVAGVVAPTL
490 500 510 520 530
1010 1020 1030 1040 1050 1060
pF1KE1 GTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQ
XP_005 PREDLEKIIAHFLIQQYLKEDYSFTAYATISYLKIGPKANLLNNEAHAITMQVTKSTQNS
540 550 560 570 580 590
>>XP_005253521 (OMIM: 600537) PREDICTED: ATP-dependent D (649 aa)
initn: 841 init1: 343 opt: 841 Z-score: 763.4 bits: 152.7 E(85289): 8.7e-36
Smith-Waterman score: 855; 34.6% identity (64.0% similar) in 483 aa overlap (509-977:51-510)
480 490 500 510 520 530
pF1KE1 LENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEED----DDKDFLWPAPNE
:..: . .:: . . . .:: : . .
XP_005 VEIQIQELTERQQELIQKKKVLTKKIKQCLEDSDAGASNEYDSSPAAWNKEDFPWSGKVK
30 40 50 60 70 80
540 550 560 570 580 590
pF1KE1 EQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLV
. :. : .:.:.: ..:. : .. :: :: :::::.: : . . ::
XP_005 D---ILQNVFKLEKFRPLQLETIN-VTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLV
90 100 110 120 130
600 610 620 630 640
pF1KE1 ISPLISLMEDQVLQLKMSNIPACFLGSAQSEN----VLTDI--KLGKYRIVYVTPEYCSG
: :::::::::.. ::. .: : .:....:.. : ... : .. ...::::: .
XP_005 ICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAK
140 150 160 170 180 190
650 660 670 680 690 700
pF1KE1 NMGLLQQLEADIG---ITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTAT
. ....:: .: :::::.:: :.:::::: ... :: :: .: . ...::::
XP_005 SKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTAT
200 210 220 230 240 250
710 720 730 740 750 760
pF1KE1 ASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEG
:.. . : . : ... ..:.::::: :::.: .: .:. .:: . ...:
XP_005 ATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNT-EDFIEDIVKLING-RYKG
260 270 280 290 300 310
770 780 790 800 810 820
pF1KE1 PT-IIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAF
. :::: :.: ..::: :..:.. :.:::.. . .:... .::: :.::.::
XP_005 QSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAF
320 330 340 350 360 370
830 840 850 860 870 880
pF1KE1 GMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIR
::::.: :.: :::.. :.::.:::: :::::: ....: . .. .:: .. . .
XP_005 GMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDI---FRISSMVV
380 390 400 410 420 430
890 900 910 920 930 940
pF1KE1 NEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLD
:. :: :... . . :.::: .. .::.. ..: .: :::: . :
XP_005 MENVGQQKLYEMVSYCQNI--SKCRRVLMAQHFDEVWNSEAC------NKMCDNCCK--D
440 450 460 470 480
950 960 970 980 990 1000
pF1KE1 HCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLF
. . . :. .:.:. .. :.::.
XP_005 SAFERKNITEYCRDL----IKILKQAEELNEKLTPLKLIDSWMGKGAAKLRVAGVVAPTL
490 500 510 520 530
1010 1020 1030 1040 1050 1060
pF1KE1 GTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQ
XP_005 PREDLEKIIAHFLIQQYLKEDYSFTAYATISYLKIGPKANLLNNEAHAITMQVTKSTQNS
540 550 560 570 580 590
>>XP_005253518 (OMIM: 600537) PREDICTED: ATP-dependent D (649 aa)
initn: 841 init1: 343 opt: 841 Z-score: 763.4 bits: 152.7 E(85289): 8.7e-36
Smith-Waterman score: 855; 34.6% identity (64.0% similar) in 483 aa overlap (509-977:51-510)
480 490 500 510 520 530
pF1KE1 LENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEED----DDKDFLWPAPNE
:..: . .:: . . . .:: : . .
XP_005 VEIQIQELTERQQELIQKKKVLTKKIKQCLEDSDAGASNEYDSSPAAWNKEDFPWSGKVK
30 40 50 60 70 80
540 550 560 570 580 590
pF1KE1 EQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLV
. :. : .:.:.: ..:. : .. :: :: :::::.: : . . ::
XP_005 D---ILQNVFKLEKFRPLQLETIN-VTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLV
90 100 110 120 130
600 610 620 630 640
pF1KE1 ISPLISLMEDQVLQLKMSNIPACFLGSAQSEN----VLTDI--KLGKYRIVYVTPEYCSG
: :::::::::.. ::. .: : .:....:.. : ... : .. ...::::: .
XP_005 ICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAK
140 150 160 170 180 190
650 660 670 680 690 700
pF1KE1 NMGLLQQLEADIG---ITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTAT
. ....:: .: :::::.:: :.:::::: ... :: :: .: . ...::::
XP_005 SKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTAT
200 210 220 230 240 250
710 720 730 740 750 760
pF1KE1 ASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEG
:.. . : . : ... ..:.::::: :::.: .: .:. .:: . ...:
XP_005 ATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNT-EDFIEDIVKLING-RYKG
260 270 280 290 300 310
770 780 790 800 810 820
pF1KE1 PT-IIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAF
. :::: :.: ..::: :..:.. :.:::.. . .:... .::: :.::.::
XP_005 QSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAF
320 330 340 350 360 370
830 840 850 860 870 880
pF1KE1 GMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIR
::::.: :.: :::.. :.::.:::: :::::: ....: . .. .:: .. . .
XP_005 GMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDI---FRISSMVV
380 390 400 410 420 430
890 900 910 920 930 940
pF1KE1 NEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLD
:. :: :... . . :.::: .. .::.. ..: .: :::: . :
XP_005 MENVGQQKLYEMVSYCQNI--SKCRRVLMAQHFDEVWNSEAC------NKMCDNCCK--D
440 450 460 470 480
950 960 970 980 990 1000
pF1KE1 HCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLF
. . . :. .:.:. .. :.::.
XP_005 SAFERKNITEYCRDL----IKILKQAEELNEKLTPLKLIDSWMGKGAAKLRVAGVVAPTL
490 500 510 520 530
1010 1020 1030 1040 1050 1060
pF1KE1 GTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQ
XP_005 PREDLEKIIAHFLIQQYLKEDYSFTAYATISYLKIGPKANLLNNEAHAITMQVTKSTQNS
540 550 560 570 580 590
>>NP_002898 (OMIM: 600537) ATP-dependent DNA helicase Q1 (649 aa)
initn: 841 init1: 343 opt: 841 Z-score: 763.4 bits: 152.7 E(85289): 8.7e-36
Smith-Waterman score: 855; 34.6% identity (64.0% similar) in 483 aa overlap (509-977:51-510)
480 490 500 510 520 530
pF1KE1 LENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEED----DDKDFLWPAPNE
:..: . .:: . . . .:: : . .
NP_002 VEIQIQELTERQQELIQKKKVLTKKIKQCLEDSDAGASNEYDSSPAAWNKEDFPWSGKVK
30 40 50 60 70 80
540 550 560 570 580 590
pF1KE1 EQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLV
. :. : .:.:.: ..:. : .. :: :: :::::.: : . . ::
NP_002 D---ILQNVFKLEKFRPLQLETIN-VTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLV
90 100 110 120 130
600 610 620 630 640
pF1KE1 ISPLISLMEDQVLQLKMSNIPACFLGSAQSEN----VLTDI--KLGKYRIVYVTPEYCSG
: :::::::::.. ::. .: : .:....:.. : ... : .. ...::::: .
NP_002 ICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAK
140 150 160 170 180 190
650 660 670 680 690 700
pF1KE1 NMGLLQQLEADIG---ITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTAT
. ....:: .: :::::.:: :.:::::: ... :: :: .: . ...::::
NP_002 SKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTAT
200 210 220 230 240 250
710 720 730 740 750 760
pF1KE1 ASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEG
:.. . : . : ... ..:.::::: :::.: .: .:. .:: . ...:
NP_002 ATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNT-EDFIEDIVKLING-RYKG
260 270 280 290 300 310
770 780 790 800 810 820
pF1KE1 PT-IIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAF
. :::: :.: ..::: :..:.. :.:::.. . .:... .::: :.::.::
NP_002 QSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAF
320 330 340 350 360 370
830 840 850 860 870 880
pF1KE1 GMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIR
::::.: :.: :::.. :.::.:::: :::::: ....: . .. .:: .. . .
NP_002 GMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDI---FRISSMVV
380 390 400 410 420 430
890 900 910 920 930 940
pF1KE1 NEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLD
:. :: :... . . :.::: .. .::.. ..: .: :::: . :
NP_002 MENVGQQKLYEMVSYCQNI--SKCRRVLMAQHFDEVWNSEAC------NKMCDNCCK--D
440 450 460 470 480
950 960 970 980 990 1000
pF1KE1 HCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLF
. . . :. .:.:. .. :.::.
NP_002 SAFERKNITEYCRDL----IKILKQAEELNEKLTPLKLIDSWMGKGAAKLRVAGVVAPTL
490 500 510 520 530
1010 1020 1030 1040 1050 1060
pF1KE1 GTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQ
NP_002 PREDLEKIIAHFLIQQYLKEDYSFTAYATISYLKIGPKANLLNNEAHAITMQVTKSTQNS
540 550 560 570 580 590
>>XP_006720695 (OMIM: 210900,604610) PREDICTED: Bloom sy (763 aa)
initn: 751 init1: 251 opt: 653 Z-score: 593.3 bits: 121.4 E(85289): 2.6e-26
Smith-Waterman score: 819; 32.1% identity (63.7% similar) in 507 aa overlap (544-1030:9-503)
520 530 540 550 560 570
pF1KE1 NEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMAT
:: .:. : ..:...: . : .: :
XP_006 MMKIFHKKFGLHNFRTNQLEAINAALLGE-DCFILMPT
10 20 30
580 590 600 610 620 630
pF1KE1 GYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDI--
: :::::.: : . .::::: ::. ::: .: .::: .: . .... :.:
XP_006 GGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYLTGDKTDSEATNIYL
40 50 60 70 80 90
640 650 660 670 680
pF1KE1 KLGK----YRIVYVTPE-YCSGN--MGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSF
.:.: ...::::: :..: .. :..: .. ...:::::.:.::::::...
XP_006 QLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDY
100 110 120 130 140 150
690 700 710 720 730 740
pF1KE1 RKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNL-YLEVRRKT
.... :. .: ::..::::::. ...::. :.. ::. .:.: :: : . .:
XP_006 KRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKP
160 170 180 190 200 210
750 760 770 780 790 800
pF1KE1 GNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTR
.. : .. : : ... :::: ::. . .. :.. .:. .::::.: :.:
XP_006 KKVAFDCLEWIRK---HHPYDSG-IIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSAR
220 230 240 250 260 270
810 820 830 840 850 860
pF1KE1 KDIHHRFV-RDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQS
....... .: : . :::::::::.: :.: ::: . ::..:.:::: ::::::: :
XP_006 DEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEIS
280 290 300 310 320 330
870 880 890 900 910
pF1KE1 SCHVLWAPADIN-LNRHLLTEIR-NEKFRLYKLKMMAKMEKYLHS-SRCRRQIILSHFED
: .... :.. :.: .. : :.. : ... . .: .: .. ..::: .:..: .
XP_006 HCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGE
340 350 360 370 380 390
920 930 940 950 960 970
pF1KE1 KQVQKASLGIMGTEKCCDNCRSRLDH-CYSMDDSEDTSWDF-----GPQAFKLLSAVDIL
. . .. . :::: . :. .. :. . : . :... .. :
XP_006 NGFNP-DFCKKHPDVSCDNCCKTKDYKTRDVTDDVKSIVRFVQEHSSSQGMRNIKHVGPS
400 410 420 430 440 450
980 990 1000 1010 1020 1030
pF1KE1 GEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSR
: .: ... . .. ::.: .. . ..:: :. .. . . ..:: . .: :
XP_006 G-RFTMNMLVDIFLGSKSAKI-----QSGIFGKGSAYSRHNAERLFKKLILDKILDEDLY
460 470 480 490 500
1040 1050 1060 1070 1080 1090
pF1KE1 YNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQ
XP_006 INANDQAIAYVMLGNKAQTVLNGNLKVDFMETENSSSVKKQKALVAKVSQREEMVKKCLG
510 520 530 540 550 560
1432 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 16:10:36 2016 done: Sun Nov 6 16:10:37 2016
Total Scan time: 11.780 Total Display time: 0.280
Function used was FASTA [36.3.4 Apr, 2011]