Result of FASTA (omim) for
pF1KE1599
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1599, 1165 aa
1>>>pF1KE1599 1165 - 1165 aa - 1165 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5079+/-0.000504; mu= 15.6182+/- 0.031
mean_var=97.9854+/-18.975, 0's: 0 Z-trim(110.3): 112 B-trim: 364 in 1/53
Lambda= 0.129567
statistics sampled from 18565 (18683) to 18565 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.569), E-opt: 0.2 (0.219), width: 16
Scan time: 10.640
The best scores are: opt bits E(85289)
NP_002294 (OMIM: 601007,614963) leptin receptor is (1165) 7962 1500.2 0
NP_001185617 (OMIM: 601007,614963) leptin receptor ( 906) 6163 1163.9 0
NP_001003679 (OMIM: 601007,614963) leptin receptor ( 896) 6161 1163.5 0
NP_001185618 (OMIM: 601007,614963) leptin receptor ( 896) 6161 1163.5 0
NP_001185616 (OMIM: 601007,614963) leptin receptor ( 958) 6161 1163.5 0
NP_001003680 (OMIM: 601007,614963) leptin receptor ( 958) 6161 1163.5 0
NP_002175 (OMIM: 600694) interleukin-6 receptor su ( 918) 385 83.8 5.4e-15
NP_001284499 (OMIM: 609510,613955) interleukin-31 ( 582) 304 68.6 1.3e-10
XP_011541445 (OMIM: 609510,613955) PREDICTED: inte ( 662) 304 68.6 1.5e-10
NP_001229567 (OMIM: 609510,613955) interleukin-31 ( 662) 304 68.6 1.5e-10
NP_001229566 (OMIM: 609510,613955) interleukin-31 ( 681) 304 68.6 1.5e-10
XP_011541444 (OMIM: 609510,613955) PREDICTED: inte ( 732) 304 68.6 1.6e-10
NP_001229565 (OMIM: 609510,613955) interleukin-31 ( 745) 304 68.6 1.6e-10
NP_620586 (OMIM: 609510,613955) interleukin-31 rec ( 764) 304 68.6 1.7e-10
NP_001177910 (OMIM: 600694) interleukin-6 receptor ( 857) 291 66.2 1e-09
NP_001284501 (OMIM: 609510,613955) interleukin-31 ( 440) 262 60.6 2.4e-08
NP_001229568 (OMIM: 609510,613955) interleukin-31 ( 622) 262 60.7 3.3e-08
XP_011541446 (OMIM: 609510,613955) PREDICTED: inte ( 622) 262 60.7 3.3e-08
XP_016865509 (OMIM: 105250,601743) PREDICTED: onco ( 647) 250 58.5 1.6e-07
XP_016864931 (OMIM: 600694) PREDICTED: interleukin ( 617) 248 58.1 2e-07
XP_011541447 (OMIM: 609510,613955) PREDICTED: inte ( 594) 243 57.2 3.7e-07
NP_786943 (OMIM: 600694) interleukin-6 receptor su ( 329) 214 51.6 9.6e-06
NP_005746 (OMIM: 605816) interleukin-27 subunit be ( 229) 195 48.0 8.3e-05
XP_011525921 (OMIM: 605816) PREDICTED: interleukin ( 229) 195 48.0 8.3e-05
NP_001136256 (OMIM: 600939,614188) interleukin-11 ( 422) 192 47.5 0.0002
XP_011526726 (OMIM: 272430,604237) PREDICTED: cyto ( 404) 185 46.2 0.00049
XP_011526725 (OMIM: 272430,604237) PREDICTED: cyto ( 419) 185 46.2 0.0005
NP_004741 (OMIM: 272430,604237) cytokine receptor- ( 422) 185 46.2 0.00051
XP_011526724 (OMIM: 272430,604237) PREDICTED: cyto ( 423) 185 46.2 0.00051
NP_001191246 (OMIM: 176761,615554,615555) prolacti ( 288) 169 43.2 0.0029
XP_016865135 (OMIM: 176761,615554,615555) PREDICTE ( 309) 169 43.2 0.0031
NP_001191244 (OMIM: 176761,615554,615555) prolacti ( 349) 169 43.2 0.0034
NP_001191245 (OMIM: 176761,615554,615555) prolacti ( 376) 169 43.2 0.0036
XP_016874764 (OMIM: 603317,613391) PREDICTED: phos (2145) 179 45.5 0.0043
NP_001138498 (OMIM: 603317,613391) phosphatidylino (2299) 179 45.5 0.0046
XP_016874763 (OMIM: 603317,613391) PREDICTED: phos (2533) 179 45.5 0.005
XP_016874762 (OMIM: 603317,613391) PREDICTED: phos (2536) 179 45.5 0.005
XP_006714547 (OMIM: 176761,615554,615555) PREDICTE ( 622) 169 43.3 0.0056
XP_011512371 (OMIM: 176761,615554,615555) PREDICTE ( 622) 169 43.3 0.0056
NP_000940 (OMIM: 176761,615554,615555) prolactin r ( 622) 169 43.3 0.0056
XP_011512370 (OMIM: 176761,615554,615555) PREDICTE ( 622) 169 43.3 0.0056
NP_001193795 (OMIM: 147880,614689,614752) interleu ( 352) 164 42.3 0.0066
>>NP_002294 (OMIM: 601007,614963) leptin receptor isofor (1165 aa)
initn: 7962 init1: 7962 opt: 7962 Z-score: 8043.1 bits: 1500.2 E(85289): 0
Smith-Waterman score: 7962; 100.0% identity (100.0% similar) in 1165 aa overlap (1-1165:1-1165)
10 20 30 40 50 60
pF1KE1 MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFI
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 KHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFN
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 SVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 KDSFSNSSWEIEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KDSFSNSSWEIEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 GVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKTFAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKTFAS
1090 1100 1110 1120 1130 1140
1150 1160
pF1KE1 YMPQFQTCSTQTHKIMENKMCDLTV
:::::::::::::::::::::::::
NP_002 YMPQFQTCSTQTHKIMENKMCDLTV
1150 1160
>>NP_001185617 (OMIM: 601007,614963) leptin receptor iso (906 aa)
initn: 6161 init1: 6161 opt: 6163 Z-score: 6227.3 bits: 1163.9 E(85289): 0
Smith-Waterman score: 6163; 99.4% identity (99.4% similar) in 900 aa overlap (1-898:1-900)
10 20 30 40 50 60
pF1KE1 MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
790 800 810 820 830 840
850 860 870 880 890
pF1KE1 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQK--PETFEHL
::::::::::::::::::::::::::::::::::::::::::::::::::: : : : :
NP_001 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKKMPGTKELL
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE1 FIKHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQ
NP_001 GGGWLT
>>NP_001003679 (OMIM: 601007,614963) leptin receptor iso (896 aa)
initn: 6161 init1: 6161 opt: 6161 Z-score: 6225.4 bits: 1163.5 E(85289): 0
Smith-Waterman score: 6161; 100.0% identity (100.0% similar) in 891 aa overlap (1-891:1-891)
10 20 30 40 50 60
pF1KE1 MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFI
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKRTDIL
850 860 870 880 890
910 920 930 940 950 960
pF1KE1 KHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFN
>>NP_001185618 (OMIM: 601007,614963) leptin receptor iso (896 aa)
initn: 6161 init1: 6161 opt: 6161 Z-score: 6225.4 bits: 1163.5 E(85289): 0
Smith-Waterman score: 6161; 100.0% identity (100.0% similar) in 891 aa overlap (1-891:1-891)
10 20 30 40 50 60
pF1KE1 MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFI
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKRTDIL
850 860 870 880 890
910 920 930 940 950 960
pF1KE1 KHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFN
>>NP_001185616 (OMIM: 601007,614963) leptin receptor iso (958 aa)
initn: 6161 init1: 6161 opt: 6161 Z-score: 6224.9 bits: 1163.5 E(85289): 0
Smith-Waterman score: 6161; 100.0% identity (100.0% similar) in 891 aa overlap (1-891:1-891)
10 20 30 40 50 60
pF1KE1 MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFI
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKMLEGSMFVK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 KHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFN
NP_001 SHHHSLISSTQGHKHCGRPQGPLHRKTRDLCSLVYLLTLPPLLSYDPAKSPSVRNTQE
910 920 930 940 950
>>NP_001003680 (OMIM: 601007,614963) leptin receptor iso (958 aa)
initn: 6161 init1: 6161 opt: 6161 Z-score: 6224.9 bits: 1163.5 E(85289): 0
Smith-Waterman score: 6161; 100.0% identity (100.0% similar) in 891 aa overlap (1-891:1-891)
10 20 30 40 50 60
pF1KE1 MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFI
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKMLEGSMFVK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 KHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFN
NP_001 SHHHSLISSTQGHKHCGRPQGPLHRKTRDLCSLVYLLTLPPLLSYDPAKSPSVRNTQE
910 920 930 940 950
>>NP_002175 (OMIM: 600694) interleukin-6 receptor subuni (918 aa)
initn: 278 init1: 107 opt: 385 Z-score: 390.1 bits: 83.8 E(85289): 5.4e-15
Smith-Waterman score: 437; 22.6% identity (53.3% similar) in 514 aa overlap (337-830:33-515)
310 320 330 340 350 360
pF1KE1 QVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI---VPS
: . .... :: . :. :.. : .
NP_002 TLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNA
10 20 30 40 50 60
370 380 390 400 410 420
pF1KE1 KEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYA
. ::: : ::. :: ... .:.::: .. . . :: .
NP_002 NYIVWKTN-HFTIPKEQYTIINRTASSVTFTDIA--------SLNIQLTCNILTFGQLEQ
70 80 90 100 110
430 440 450 460 470
pF1KE1 ELYVIDV--------NINISC-ETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCS
..: : . :.:: ..: :: :.:. . :. :. . .: . .
NP_002 NVYGITIISGLPPEKPKNLSCIVNEG--KKMRCEWDGGR-----ETHLETNFTLKSEWAT
120 130 140 150 160
480 490 500 510 520 530
pF1KE1 DIPSIHPISEPKDCYLQSDGFYECI--FQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPD
: .. :: . : : .. ..... .:.. ...::.. : :
NP_002 -----HKFA---DCKAKRDTPTSCTVDYSTVYFVN-IEVWVEAENALGKVTSDHINFDPV
170 180 190 200 210
540 550 560 570 580 590
pF1KE1 SVVKPLPPSSVKAEITINIG-LLKISWEKPVFPENN-LQFQIRYGLSGKEVQWKMYEVYD
::: :: .... . ... .::..: .: . :...:.: . . :.. :
NP_002 YKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDAST-WSQIPPED
220 230 240 250 260 270
600 610 620 630 640
pF1KE1 AKSKSVSLPVPDLCAV--YAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRI
. : :. : :: :. ..:: . :: ::::.::. : .... . : ..: ::
NP_002 TASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDR-PSKAPSFWYK
280 290 300 310 320 330
650 660 670 680 690 700
pF1KE1 INGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQ
:. . . ..: :.:: : .. .. : .. . . : : ::.: :..
NP_002 IDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV-NATKLTVNLTND
340 350 360 370 380 390
710 720 730 740 750 760
pF1KE1 AHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLM
. .:. . : .: : : . .. .. :..:.:.: ... . : : .: . ..
NP_002 RYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFP-KDNMLWVEWT-TPRE-SVK
400 410 420 430 440 450
770 780 790 800 810 820
pF1KE1 YFIIEWKNLNEDGE--IKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIIN
.:.:: :.. . : . ...:.. :.. .. . : ... :.. .: :.:. :.
NP_002 KYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIK
460 470 480 490 500 510
830 840 850 860 870 880
pF1KE1 SFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQG
.. .
NP_002 AYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVD
520 530 540 550 560 570
>>NP_001284499 (OMIM: 609510,613955) interleukin-31 rece (582 aa)
initn: 128 init1: 66 opt: 304 Z-score: 311.3 bits: 68.6 E(85289): 1.3e-10
Smith-Waterman score: 304; 22.5% identity (54.8% similar) in 418 aa overlap (433-833:59-452)
410 420 430 440 450 460
pF1KE1 GKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTL
:::: . : ..:: :: . : .. :.
NP_001 VNLGMMWTWALWMLPSLCKFSLAALPAKPENISC-VYYYRKNLTCTWSPGKETSYTQYTV
30 40 50 60 70 80
470 480 490 500 510
pF1KE1 QLRYHRSSLY--CSDIPSIHPISEPKDCYLQSDGFYECIFQP-IFLLSGYTMWIRINHSL
. : . . :. : :: . : .: : : : . ..::. .. ...
NP_001 KRTYAFGEKHDNCTTNSST---SENR----ASCSF----FLPRITIPDNYTIEVEAENGD
90 100 110 120 130
520 530 540 550 560 570
pF1KE1 GSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF-P-ENNLQFQIRYGL
: . : : ....: ::. ... ...: ...: : :: . : ..:.. .:.
NP_001 GVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRT
140 150 160 170 180 190
580 590 600 610 620 630
pF1KE1 SGKEVQWKMYEVYDAKSKSVSLPVPDLCAV--YAVQVRCKRLDGLGYWSNWSNPAYTVVM
.. .. . . :.:. . . : :.. .:: .. .::.::. . ..
NP_001 VNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVIALRCAVKES-KFWSDWSQEKMGMTE
200 210 220 230 240 250
640 650 660 670 680 690
pF1KE1 DIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSED
. ..: : :.::... .. : :::: : .. : : .. : . .:
NP_001 E-EAPC-GLELWRVLKPAEADGRRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTET
260 270 280 290 300 310
700 710 720 730 740 750
pF1KE1 VGN-HTKFTFLWTEQAHTVTVLAINSIGAS-VANFNLTFSWPMSKVNIVQSLSAYPLNSS
... . .. . .. :.... ::.: : :: :. : . .:.. . ..
NP_001 MNTTNQQLELHLGGESFWVSMISYNSLGKSPVA----TLRIPAIQE---KSFQCIEVMQA
320 330 340 350 360
760 770 780 790 800
pF1KE1 CV-----IVSWILSPSDYKLMYFIIEW-KNLN-EDGEIKWLRISSSVKKYYIHDHFIPIE
:: .:.: : : . ..::: ... : ..: .:.... .:.. :.
NP_001 CVAEDQLVVKWQSSALDVNT--WMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKLKPFW
370 380 390 400 410 420
810 820 830 840 850 860
pF1KE1 KYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQ
:..:.::.. . ::.: :...... .
NP_001 CYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSERKGI
430 440 450 460 470 480
>>XP_011541445 (OMIM: 609510,613955) PREDICTED: interleu (662 aa)
initn: 128 init1: 66 opt: 304 Z-score: 310.5 bits: 68.6 E(85289): 1.5e-10
Smith-Waterman score: 304; 22.5% identity (54.8% similar) in 418 aa overlap (433-833:40-433)
410 420 430 440 450 460
pF1KE1 GKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTL
:::: . : ..:: :: . : .. :.
XP_011 VNLGMMWTWALWMLPSLCKFSLAALPAKPENISC-VYYYRKNLTCTWSPGKETSYTQYTV
10 20 30 40 50 60
470 480 490 500 510
pF1KE1 QLRYHRSSLY--CSDIPSIHPISEPKDCYLQSDGFYECIFQP-IFLLSGYTMWIRINHSL
. : . . :. : :: . : .: : : : . ..::. .. ...
XP_011 KRTYAFGEKHDNCTTNSST---SENR----ASCSF----FLPRITIPDNYTIEVEAENGD
70 80 90 100 110
520 530 540 550 560 570
pF1KE1 GSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF-P-ENNLQFQIRYGL
: . : : ....: ::. ... ...: ...: : :: . : ..:.. .:.
XP_011 GVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRT
120 130 140 150 160 170
580 590 600 610 620 630
pF1KE1 SGKEVQWKMYEVYDAKSKSVSLPVPDLCAV--YAVQVRCKRLDGLGYWSNWSNPAYTVVM
.. .. . . :.:. . . : :.. .:: .. .::.::. . ..
XP_011 VNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVIALRCAVKES-KFWSDWSQEKMGMTE
180 190 200 210 220 230
640 650 660 670 680 690
pF1KE1 DIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSED
. ..: : :.::... .. : :::: : .. : : .. : . .:
XP_011 E-EAPC-GLELWRVLKPAEADGRRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTET
240 250 260 270 280 290
700 710 720 730 740 750
pF1KE1 VGN-HTKFTFLWTEQAHTVTVLAINSIGAS-VANFNLTFSWPMSKVNIVQSLSAYPLNSS
... . .. . .. :.... ::.: : :: :. : . .:.. . ..
XP_011 MNTTNQQLELHLGGESFWVSMISYNSLGKSPVA----TLRIPAIQE---KSFQCIEVMQA
300 310 320 330 340
760 770 780 790 800
pF1KE1 CV-----IVSWILSPSDYKLMYFIIEW-KNLN-EDGEIKWLRISSSVKKYYIHDHFIPIE
:: .:.: : : . ..::: ... : ..: .:.... .:.. :.
XP_011 CVAEDQLVVKWQSSALDVNT--WMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKLKPFW
350 360 370 380 390 400
810 820 830 840 850 860
pF1KE1 KYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQ
:..:.::.. . ::.: :...... .
XP_011 CYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSERKGI
410 420 430 440 450 460
>>NP_001229567 (OMIM: 609510,613955) interleukin-31 rece (662 aa)
initn: 128 init1: 66 opt: 304 Z-score: 310.5 bits: 68.6 E(85289): 1.5e-10
Smith-Waterman score: 304; 22.5% identity (54.8% similar) in 418 aa overlap (433-833:40-433)
410 420 430 440 450 460
pF1KE1 GKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTL
:::: . : ..:: :: . : .. :.
NP_001 VNLGMMWTWALWMLPSLCKFSLAALPAKPENISC-VYYYRKNLTCTWSPGKETSYTQYTV
10 20 30 40 50 60
470 480 490 500 510
pF1KE1 QLRYHRSSLY--CSDIPSIHPISEPKDCYLQSDGFYECIFQP-IFLLSGYTMWIRINHSL
. : . . :. : :: . : .: : : : . ..::. .. ...
NP_001 KRTYAFGEKHDNCTTNSST---SENR----ASCSF----FLPRITIPDNYTIEVEAENGD
70 80 90 100 110
520 530 540 550 560 570
pF1KE1 GSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF-P-ENNLQFQIRYGL
: . : : ....: ::. ... ...: ...: : :: . : ..:.. .:.
NP_001 GVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRT
120 130 140 150 160 170
580 590 600 610 620 630
pF1KE1 SGKEVQWKMYEVYDAKSKSVSLPVPDLCAV--YAVQVRCKRLDGLGYWSNWSNPAYTVVM
.. .. . . :.:. . . : :.. .:: .. .::.::. . ..
NP_001 VNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVIALRCAVKES-KFWSDWSQEKMGMTE
180 190 200 210 220 230
640 650 660 670 680 690
pF1KE1 DIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSED
. ..: : :.::... .. : :::: : .. : : .. : . .:
NP_001 E-EAPC-GLELWRVLKPAEADGRRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTET
240 250 260 270 280 290
700 710 720 730 740 750
pF1KE1 VGN-HTKFTFLWTEQAHTVTVLAINSIGAS-VANFNLTFSWPMSKVNIVQSLSAYPLNSS
... . .. . .. :.... ::.: : :: :. : . .:.. . ..
NP_001 MNTTNQQLELHLGGESFWVSMISYNSLGKSPVA----TLRIPAIQE---KSFQCIEVMQA
300 310 320 330 340
760 770 780 790 800
pF1KE1 CV-----IVSWILSPSDYKLMYFIIEW-KNLN-EDGEIKWLRISSSVKKYYIHDHFIPIE
:: .:.: : : . ..::: ... : ..: .:.... .:.. :.
NP_001 CVAEDQLVVKWQSSALDVNT--WMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKLKPFW
350 360 370 380 390 400
810 820 830 840 850 860
pF1KE1 KYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQ
:..:.::.. . ::.: :...... .
NP_001 CYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSERKGI
410 420 430 440 450 460
1165 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 19:17:51 2016 done: Sun Nov 6 19:17:53 2016
Total Scan time: 10.640 Total Display time: 0.330
Function used was FASTA [36.3.4 Apr, 2011]