FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1686, 198 aa 1>>>pF1KE1686 198 - 198 aa - 198 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9918+/-0.000307; mu= 15.0541+/- 0.019 mean_var=60.4381+/-12.236, 0's: 0 Z-trim(116.5): 21 B-trim: 244 in 1/49 Lambda= 0.164975 statistics sampled from 27621 (27642) to 27621 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.715), E-opt: 0.2 (0.324), width: 16 Scan time: 6.040 The best scores are: opt bits E(85289) NP_005555 (OMIM: 600181) neutrophil gelatinase-ass ( 198) 1337 326.1 2.3e-89 NP_848631 (OMIM: 612905) epididymal-specific lipoc ( 192) 373 96.6 2.7e-20 XP_016870120 (OMIM: 612905) PREDICTED: epididymal- ( 227) 373 96.7 3.1e-20 XP_006717128 (OMIM: 612905) PREDICTED: epididymal- ( 355) 373 96.8 4.4e-20 XP_011516864 (OMIM: 612905) PREDICTED: epididymal- ( 355) 373 96.8 4.4e-20 XP_011516862 (OMIM: 612905) PREDICTED: epididymal- ( 382) 373 96.8 4.7e-20 XP_011516863 (OMIM: 612905) PREDICTED: epididymal- ( 383) 373 96.8 4.7e-20 NP_000945 (OMIM: 176803) prostaglandin-H2 D-isomer ( 190) 323 84.7 1e-16 XP_016870121 (OMIM: 612905) PREDICTED: epididymal- ( 184) 262 70.2 2.3e-12 NP_001624 (OMIM: 176870) protein AMBP preproprotei ( 352) 210 58.0 2.1e-08 NP_000597 (OMIM: 120930) complement component C8 g ( 202) 146 42.6 0.00051 >>NP_005555 (OMIM: 600181) neutrophil gelatinase-associa (198 aa) initn: 1337 init1: 1337 opt: 1337 Z-score: 1725.3 bits: 326.1 E(85289): 2.3e-89 Smith-Waterman score: 1337; 100.0% identity (100.0% similar) in 198 aa overlap (1-198:1-198) 10 20 30 40 50 60 pF1KE1 MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNIKSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNIKSY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 PGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENFIRFSKSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENFIRFSKSLG 130 140 150 160 170 180 190 pF1KE1 LPENHIVFPVPIDQCIDG :::::::::::::::::: NP_005 LPENHIVFPVPIDQCIDG 190 >>NP_848631 (OMIM: 612905) epididymal-specific lipocalin (192 aa) initn: 440 init1: 251 opt: 373 Z-score: 485.5 bits: 96.6 E(85289): 2.7e-20 Smith-Waterman score: 397; 35.3% identity (66.8% similar) in 184 aa overlap (6-189:7-180) 10 20 30 40 50 pF1KE1 MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGN ::: :.:: .:.:: : .: :: :.: .:: :::::.:.:.::::: NP_848 MRLLCGLWLWLSLLKVLQAQ----TPTPLPLPP----PMQ-SFQGNQFQGEWFVLGLAGN 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 AILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNIKS .. : . . ... .::..: ..: ... : ..:: : ...:. :::.::. . NP_848 SFRPEHRALLNAFTATFELSDDGRFEVWNAMTRGQHCDTWSYVLIPAAQPGQFTVDH-GV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 YPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENFIRFSKSL :: .:::...:.: :... .. .. ..:.: ::. : ..:: .... NP_848 EPGADREETRVVDSDYTQFALMLSRRHTSRLAVLRISLLGRSWLLPPGTLDQFICLGRAQ 120 130 140 150 160 170 180 190 pF1KE1 GLPENHIVFPVPIDQCIDG :: ...:::: NP_848 GLSDDNIVFPDVTGWSPQASVC 180 190 >>XP_016870120 (OMIM: 612905) PREDICTED: epididymal-spec (227 aa) initn: 440 init1: 251 opt: 373 Z-score: 484.4 bits: 96.7 E(85289): 3.1e-20 Smith-Waterman score: 397; 35.3% identity (66.8% similar) in 184 aa overlap (6-189:35-208) 10 20 30 pF1KE1 MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSK ::: :.:: .:.:: : .: :: XP_016 RWVSGSPAHGHFLLSVPVGPAAARMRLLCGLWLWLSLLKVLQAQ----TPTPLPLPP--- 10 20 30 40 50 40 50 60 70 80 90 pF1KE1 VPLQQNFQDNQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKK :.: .:: :::::.:.:.:::::.. : . . ... .::..: ..: ... : .. XP_016 -PMQ-SFQGNQFQGEWFVLGLAGNSFRPEHRALLNAFTATFELSDDGRFEVWNAMTRGQH 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE1 CDYWIRTFVPGCQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKI :: : ...:. :::.::. . :: .:::...:.: :... .. .. ..: XP_016 CDTWSYVLIPAAQPGQFTVDH-GVEPGADREETRVVDSDYTQFALMLSRRHTSRLAVLRI 120 130 140 150 160 170 160 170 180 190 pF1KE1 TLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDG .: ::. : ..:: .... :: ...:::: XP_016 SLLGRSWLLPPGTLDQFICLGRAQGLSDDNIVFPDVTGGALDLSSLPWVAAPA 180 190 200 210 220 >>XP_006717128 (OMIM: 612905) PREDICTED: epididymal-spec (355 aa) initn: 440 init1: 251 opt: 373 Z-score: 481.5 bits: 96.8 E(85289): 4.4e-20 Smith-Waterman score: 397; 35.3% identity (66.8% similar) in 184 aa overlap (6-189:7-180) 10 20 30 40 50 pF1KE1 MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGN ::: :.:: .:.:: : .: :: :.: .:: :::::.:.:.::::: XP_006 MRLLCGLWLWLSLLKVLQAQ----TPTPLPLPP----PMQ-SFQGNQFQGEWFVLGLAGN 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 AILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNIKS .. : . . ... .::..: ..: ... : ..:: : ...:. :::.::. . XP_006 SFRPEHRALLNAFTATFELSDDGRFEVWNAMTRGQHCDTWSYVLIPAAQPGQFTVDH-GV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 YPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENFIRFSKSL :: .:::...:.: :... .. .. ..:.: ::. : ..:: .... XP_006 EPGADREETRVVDSDYTQFALMLSRRHTSRLAVLRISLLGRSWLLPPGTLDQFICLGRAQ 120 130 140 150 160 170 180 190 pF1KE1 GLPENHIVFPVPIDQCIDG :: ...:::: XP_006 GLSDDNIVFPDVTGNMVHLQACWAVGTGPAGMSLVDPRGAGPSVYPGSSAPACAQGSPGS 180 190 200 210 220 230 >>XP_011516864 (OMIM: 612905) PREDICTED: epididymal-spec (355 aa) initn: 440 init1: 251 opt: 373 Z-score: 481.5 bits: 96.8 E(85289): 4.4e-20 Smith-Waterman score: 397; 35.3% identity (66.8% similar) in 184 aa overlap (6-189:7-180) 10 20 30 40 50 pF1KE1 MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGN ::: :.:: .:.:: : .: :: :.: .:: :::::.:.:.::::: XP_011 MRLLCGLWLWLSLLKVLQAQ----TPTPLPLPP----PMQ-SFQGNQFQGEWFVLGLAGN 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 AILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNIKS .. : . . ... .::..: ..: ... : ..:: : ...:. :::.::. . XP_011 SFRPEHRALLNAFTATFELSDDGRFEVWNAMTRGQHCDTWSYVLIPAAQPGQFTVDH-GV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 YPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENFIRFSKSL :: .:::...:.: :... .. .. ..:.: ::. : ..:: .... XP_011 EPGADREETRVVDSDYTQFALMLSRRHTSRLAVLRISLLGRSWLLPPGTLDQFICLGRAQ 120 130 140 150 160 170 180 190 pF1KE1 GLPENHIVFPVPIDQCIDG :: ...:::: XP_011 GLSDDNIVFPDVTGNMVHLQACWAVGTGPAGMSLVDPRGAGPSVYPGSSAPACAQGSPGS 180 190 200 210 220 230 >>XP_011516862 (OMIM: 612905) PREDICTED: epididymal-spec (382 aa) initn: 440 init1: 251 opt: 373 Z-score: 481.0 bits: 96.8 E(85289): 4.7e-20 Smith-Waterman score: 397; 35.3% identity (66.8% similar) in 184 aa overlap (6-189:34-207) 10 20 30 pF1KE1 MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSK ::: :.:: .:.:: : .: :: XP_011 RGGRWTWGPLLPHLAGTQETAAARMRLLCGLWLWLSLLKVLQAQ----TPTPLPLPP--- 10 20 30 40 50 40 50 60 70 80 90 pF1KE1 VPLQQNFQDNQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKK :.: .:: :::::.:.:.:::::.. : . . ... .::..: ..: ... : .. XP_011 -PMQ-SFQGNQFQGEWFVLGLAGNSFRPEHRALLNAFTATFELSDDGRFEVWNAMTRGQH 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE1 CDYWIRTFVPGCQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKI :: : ...:. :::.::. . :: .:::...:.: :... .. .. ..: XP_011 CDTWSYVLIPAAQPGQFTVDH-GVEPGADREETRVVDSDYTQFALMLSRRHTSRLAVLRI 120 130 140 150 160 170 160 170 180 190 pF1KE1 TLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDG .: ::. : ..:: .... :: ...:::: XP_011 SLLGRSWLLPPGTLDQFICLGRAQGLSDDNIVFPDVTGNMVHLQACWAVGTGPAGMSLVD 180 190 200 210 220 230 XP_011 PRGAGPSVYPGSSAPACAQGSPGSWVPVLNPGSEPPPAAPGPLSWATSSHPGSPVPGHLL 240 250 260 270 280 290 >>XP_011516863 (OMIM: 612905) PREDICTED: epididymal-spec (383 aa) initn: 440 init1: 251 opt: 373 Z-score: 481.0 bits: 96.8 E(85289): 4.7e-20 Smith-Waterman score: 397; 35.3% identity (66.8% similar) in 184 aa overlap (6-189:35-208) 10 20 30 pF1KE1 MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSK ::: :.:: .:.:: : .: :: XP_011 RWVSGSPAHGHFLLSVPVGPAAARMRLLCGLWLWLSLLKVLQAQ----TPTPLPLPP--- 10 20 30 40 50 40 50 60 70 80 90 pF1KE1 VPLQQNFQDNQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKK :.: .:: :::::.:.:.:::::.. : . . ... .::..: ..: ... : .. XP_011 -PMQ-SFQGNQFQGEWFVLGLAGNSFRPEHRALLNAFTATFELSDDGRFEVWNAMTRGQH 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE1 CDYWIRTFVPGCQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKI :: : ...:. :::.::. . :: .:::...:.: :... .. .. ..: XP_011 CDTWSYVLIPAAQPGQFTVDH-GVEPGADREETRVVDSDYTQFALMLSRRHTSRLAVLRI 120 130 140 150 160 170 160 170 180 190 pF1KE1 TLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDG .: ::. : ..:: .... :: ...:::: XP_011 SLLGRSWLLPPGTLDQFICLGRAQGLSDDNIVFPDVTGNMVHLQACWAVGTGPAGMSLVD 180 190 200 210 220 230 XP_011 PRGAGPSVYPGSSAPACAQGSPGSWVPVLNPGSEPPPAAPGPLSWATSSHPGSPVPGHLL 240 250 260 270 280 290 >>NP_000945 (OMIM: 176803) prostaglandin-H2 D-isomerase (190 aa) initn: 281 init1: 99 opt: 323 Z-score: 421.2 bits: 84.7 E(85289): 1e-16 Smith-Waterman score: 360; 35.8% identity (62.7% similar) in 193 aa overlap (6-196:7-187) 10 20 30 40 50 pF1KE1 MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGN ::.::::::.: .:: : : ..: .: :::...: :.:. .:::.: NP_000 MATHHTLWMGLALLGVL--------GDL-QAAPEAQVSVQPNFQQDKFLGRWFSAGLASN 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 AI-LREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNIK . ::: : .: .. : . :.::...::..:. . :. . : .. . NP_000 SSWLREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSY---R 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 SYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKI-TLYGRTKELTSELKENFIRFSK : ..: : :: :.:.:.:... . . : :.. :::.::. .::::.: : : NP_000 SPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCK 110 120 130 140 150 160 180 190 pF1KE1 SLGLPENHIVFPVPIDQCIDG . :. :. ::: :.:. NP_000 AQGFTEDTIVFLPQTDKCMTEQ 170 180 190 >>XP_016870121 (OMIM: 612905) PREDICTED: epididymal-spec (184 aa) initn: 324 init1: 251 opt: 262 Z-score: 342.9 bits: 70.2 E(85289): 2.3e-12 Smith-Waterman score: 286; 38.0% identity (66.9% similar) in 121 aa overlap (6-125:35-146) 10 20 30 pF1KE1 MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSK ::: :.:: .:.:: : .: :: XP_016 RWVSGSPAHGHFLLSVPVGPAAARMRLLCGLWLWLSLLKVLQAQ----TPTPLPLPP--- 10 20 30 40 50 40 50 60 70 80 90 pF1KE1 VPLQQNFQDNQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKK :.: .:: :::::.:.:.:::::.. : . . ... .::..: ..: ... : .. XP_016 -PMQ-SFQGNQFQGEWFVLGLAGNSFRPEHRALLNAFTATFELSDDGRFEVWNAMTRGQH 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE1 CDYWIRTFVPGCQPGEFTLGN-IKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFK :: : ...:. :::.::. . . . : : XP_016 CDTWSYVLIPAAQPGQFTVDHGVDTRAGWPSSGSACWAGAGCCLPGRWTSSSAWAELRAS 120 130 140 150 160 170 160 170 180 190 pF1KE1 ITLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDG XP_016 RMTTSSSQM 180 >>NP_001624 (OMIM: 176870) protein AMBP preproprotein [H (352 aa) initn: 117 init1: 73 opt: 210 Z-score: 271.9 bits: 58.0 E(85289): 2.1e-08 Smith-Waterman score: 210; 28.2% identity (56.4% similar) in 195 aa overlap (8-198:4-191) 10 20 30 40 50 60 pF1KE1 MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNA :: ::: : : :.. .:.:: ... .:.::. ... :::: ... :.. NP_001 MRSLG-ALLLLLSACLAVSAGP-VPTPP-DNIQVQENFNISRIYGKWYNLAI-GST 10 20 30 40 50 70 80 90 100 110 pF1KE1 ILREDKDPQKMYATIYELKEDKS---YNVTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNI : ..: .. : : . ..::. .:: :. .. :.: . NP_001 CPWLKKIMDRMTVSTLVLGEGATEAEISMTSTRWRKGVCEETSGAYEKTDTDGKFLYHKS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 KSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNR-EYFKITLYGRTKELTSELKENFIRFS : . :: :: :::...:. . :: :... . ::::. .: : ..: . NP_001 KWNITMESY---VVHTNYDEYAIFLTKKFSRHHGPTITAKLYGRAPQLRETLLQDFRVVA 120 130 140 150 160 180 190 pF1KE1 KSLGLPENHIVFPVPIDQCIDG ...:.::. : . .:. : NP_001 QGVGIPEDSIFTMADRGECVPGEQEPEPILIPRVRRAVLPQEEEGSGGGQLVTEVTKKED 170 180 190 200 210 220 198 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 09:55:43 2016 done: Sun Nov 6 09:55:44 2016 Total Scan time: 6.040 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]