FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1706, 211 aa 1>>>pF1KE1706 211 - 211 aa - 211 aa Library: human.CCDS.faa 18921897 residues in 33420 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1615+/-0.000592; mu= 15.0966+/- 0.036 mean_var=67.8474+/-13.594, 0's: 0 Z-trim(112.7): 36 B-trim: 656 in 1/52 Lambda= 0.155707 statistics sampled from 13592 (13628) to 13592 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.775), E-opt: 0.2 (0.408), width: 16 Scan time: 1.080 The best scores are: opt bits E(33420) CCDS5998.1 FGF20 gene_id:26281|Hs109|chr8 ( 211) 1439 331.2 2.9e-91 CCDS9298.1 FGF9 gene_id:2254|Hs109|chr13 ( 208) 995 231.5 3e-61 CCDS75996.1 FGF16 gene_id:8823|Hs109|chrX ( 207) 920 214.6 3.6e-56 CCDS9501.1 FGF14 gene_id:2259|Hs109|chr13 ( 247) 415 101.2 5.8e-22 CCDS9500.1 FGF14 gene_id:2259|Hs109|chr13 ( 252) 413 100.8 8.1e-22 CCDS34021.1 FGF5 gene_id:2250|Hs109|chr4 ( 268) 408 99.7 1.8e-21 CCDS12037.1 FGF22 gene_id:27006|Hs109|chr19 ( 170) 402 98.2 3.3e-21 CCDS3950.1 FGF10 gene_id:2255|Hs109|chr5 ( 208) 401 98.0 4.5e-21 CCDS55512.1 FGF13 gene_id:2258|Hs109|chrX ( 199) 398 97.4 6.9e-21 CCDS14664.1 FGF13 gene_id:2258|Hs109|chrX ( 192) 394 96.5 1.2e-20 CCDS55511.1 FGF13 gene_id:2258|Hs109|chrX ( 226) 394 96.5 1.4e-20 CCDS14665.1 FGF13 gene_id:2258|Hs109|chrX ( 245) 394 96.5 1.5e-20 CCDS55513.1 FGF13 gene_id:2258|Hs109|chrX ( 255) 394 96.5 1.6e-20 CCDS46983.1 FGF12 gene_id:2257|Hs109|chr3 ( 181) 385 94.4 4.8e-20 CCDS3301.1 FGF12 gene_id:2257|Hs109|chr3 ( 243) 385 94.5 6.1e-20 CCDS10131.1 FGF7 gene_id:2252|Hs109|chr15 ( 194) 377 92.6 1.8e-19 CCDS11105.1 FGF11 gene_id:2256|Hs109|chr17 ( 225) 373 91.8 3.7e-19 CCDS8527.1 FGF6 gene_id:2251|Hs109|chr12 ( 208) 348 86.1 1.7e-17 CCDS8194.1 FGF4 gene_id:2249|Hs109|chr11 ( 206) 347 85.9 2e-17 CCDS4275.1 FGF1 gene_id:2246|Hs109|chr5 ( 155) 328 81.6 3.1e-16 CCDS8195.1 FGF3 gene_id:2248|Hs109|chr11 ( 239) 330 82.1 3.2e-16 CCDS34059.1 FGF2 gene_id:2247|Hs109|chr4 ( 288) 283 71.6 5.5e-13 CCDS7517.1 FGF8 gene_id:2253|Hs109|chr10 ( 233) 249 63.9 9.3e-11 >>CCDS5998.1 FGF20 gene_id:26281|Hs109|chr8 (211 aa) initn: 1439 init1: 1439 opt: 1439 Z-score: 1752.1 bits: 331.2 E(33420): 2.9e-91 Smith-Waterman score: 1439; 100.0% identity (100.0% similar) in 211 aa overlap (1-211:1-211) 10 20 30 40 50 60 pF1KE1 MAPLAEVGGFLGGLEGLGQQVGSHFLLPPAGERPPLLGERRSAAERSARGGPGAAQLAHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 MAPLAEVGGFLGGLEGLGQQVGSHFLLPPAGERPPLLGERRSAAERSARGGPGAAQLAHL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 HGILRRRQLYCRTGFHLQILPDGSVQGTRQDHSLFGILEFISVAVGLVSIRGVDSGLYLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 HGILRRRQLYCRTGFHLQILPDGSVQGTRQDHSLFGILEFISVAVGLVSIRGVDSGLYLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 MNDKGELYGSEKLTSECIFREQFEENWYNTYSSNIYKHGDTGRRYFVALNKDGTPRDGAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 MNDKGELYGSEKLTSECIFREQFEENWYNTYSSNIYKHGDTGRRYFVALNKDGTPRDGAR 130 140 150 160 170 180 190 200 210 pF1KE1 SKRHQKFTHFLPRPVDPERVPELYKDLLMYT ::::::::::::::::::::::::::::::: CCDS59 SKRHQKFTHFLPRPVDPERVPELYKDLLMYT 190 200 210 >>CCDS9298.1 FGF9 gene_id:2254|Hs109|chr13 (208 aa) initn: 996 init1: 951 opt: 995 Z-score: 1213.2 bits: 231.5 E(33420): 3e-61 Smith-Waterman score: 995; 70.3% identity (89.5% similar) in 209 aa overlap (1-208:1-205) 10 20 30 40 50 pF1KE1 MAPLAEVGGFLGGLEGLGQQVGSHFLLPPAGERPPLLGERRSAAERSARG-GPGAAQLAH ::::.:::...: ... :. .:: . : ::... . .: .. ::....: : CCDS92 MAPLGEVGNYFGVQDAV--PFGNVPVLPV--DSPVLLSDHLGQSEAGGLPRGPAVTDLDH 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 LHGILRRRQLYCRTGFHLQILPDGSVQGTRQDHSLFGILEFISVAVGLVSIRGVDSGLYL :.::::::::::::::::.:.:.:..::::.::: ::::::::.:::::::::::::::: CCDS92 LKGILRRRQLYCRTGFHLEIFPNGTIQGTRKDHSRFGILEFISIAVGLVSIRGVDSGLYL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 GMNDKGELYGSEKLTSECIFREQFEENWYNTYSSNIYKHGDTGRRYFVALNKDGTPRDGA :::.:::::::::::.::.::::::::::::::::.::: ::::::.::::::::::.:. CCDS92 GMNEKGELYGSEKLTQECVFREQFEENWYNTYSSNLYKHVDTGRRYYVALNKDGTPREGT 120 130 140 150 160 170 180 190 200 210 pF1KE1 RSKRHQKFTHFLPRPVDPERVPELYKDLLMYT :.::::::::::::::::..:::::::.: CCDS92 RTKRHQKFTHFLPRPVDPDKVPELYKDILSQS 180 190 200 >>CCDS75996.1 FGF16 gene_id:8823|Hs109|chrX (207 aa) initn: 908 init1: 861 opt: 920 Z-score: 1122.2 bits: 214.6 E(33420): 3.6e-56 Smith-Waterman score: 920; 63.9% identity (86.1% similar) in 208 aa overlap (4-210:1-206) 10 20 30 40 50 pF1KE1 MAPLAEVGGFLGGLEGLGQQVGSHFLLPPAGERPPLLGERRSAAE-RSARGGPGAAQLAH .::::: ...:. . .: . : .. : .:.:: . : . ::.: ...:: CCDS75 MAEVGGVFASLDWDLHGFSSSLGNVPLADSPGFLNERLGQIEGKLQRGSP--TDFAH 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 LHGILRRRQLYCRTGFHLQILPDGSVQGTRQDHSLFGILEFISVAVGLVSIRGVDSGLYL :.::::::::::::::::.:.:.:.:.:::.::: ::::::::.::::.::::::::::: CCDS75 LKGILRRRQLYCRTGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVGLISIRGVDSGLYL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 GMNDKGELYGSEKLTSECIFREQFEENWYNTYSSNIYKHGDTGRRYFVALNKDGTPRDGA :::..::::::.::: ::.:::::::::::::.:..:::.:. :.:.:::::::.::.: CCDS75 GMNERGELYGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQYYVALNKDGSPREGY 120 130 140 150 160 170 180 190 200 210 pF1KE1 RSKRHQKFTHFLPRPVDPERVPELYKDLLMYT :.:::::::::::::::: ..: . .::. : CCDS75 RTKRHQKFTHFLPRPVDPSKLPSMSRDLFHYR 180 190 200 >>CCDS9501.1 FGF14 gene_id:2259|Hs109|chr13 (247 aa) initn: 420 init1: 399 opt: 415 Z-score: 508.0 bits: 101.2 E(33420): 5.8e-22 Smith-Waterman score: 415; 42.4% identity (72.2% similar) in 151 aa overlap (56-204:64-212) 30 40 50 60 70 80 pF1KE1 LLPPAGERPPLLGERRSAAERSARGGPGAAQLAHLHGILRRRQLYCRTGFHLQILPDGSV : .:.::. : :::: :..::. :::.. CCDS95 SKNRGLCNGNLVDIFSKVRIFGLKKRRLRRQDPQLKGIVTR--LYCRQGYYLQMHPDGAL 40 50 60 70 80 90 90 100 110 120 130 140 pF1KE1 QGTRQDHSLFGILEFISVAVGLVSIRGVDSGLYLGMNDKGELYGSEKLTSECIFREQFEE .::..: . ....: :.. .:.:.:: .:::..:: .: :: :: .: :: :.:. : CCDS95 DGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVFE 100 110 120 130 140 150 150 160 170 180 190 200 pF1KE1 NWYNTYSSNIYKHGDTGRRYFVALNKDGTPRDGARSKRHQKFTHFLPRPVDPE--RVPEL :.: ::: .:.. ..:: .:..:::.: : : :. . .::::.:.. : : : CCDS95 NYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAMYREPSL 160 170 180 190 200 210 210 pF1KE1 YKDLLMYT . CCDS95 HDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT 220 230 240 >>CCDS9500.1 FGF14 gene_id:2259|Hs109|chr13 (252 aa) initn: 415 init1: 399 opt: 413 Z-score: 505.4 bits: 100.8 E(33420): 8.1e-22 Smith-Waterman score: 413; 42.6% identity (73.0% similar) in 148 aa overlap (59-204:72-217) 30 40 50 60 70 80 pF1KE1 PAGERPPLLGERRSAAERSARGGPGAAQLAHLHGILRRRQLYCRTGFHLQILPDGSVQGT .:.::. : :::: :..::. :::...:: CCDS95 FLWNIFSKGTHMLQCLCGKSLKKNKNPTDPQLKGIVTR--LYCRQGYYLQMHPDGALDGT 50 60 70 80 90 90 100 110 120 130 140 pF1KE1 RQDHSLFGILEFISVAVGLVSIRGVDSGLYLGMNDKGELYGSEKLTSECIFREQFEENWY ..: . ....: :.. .:.:.:: .:::..:: .: :: :: .: :: :.:. ::.: CCDS95 KDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVFENYY 100 110 120 130 140 150 150 160 170 180 190 200 pF1KE1 NTYSSNIYKHGDTGRRYFVALNKDGTPRDGARSKRHQKFTHFLPRPVDPE--RVPELYKD ::: .:.. ..:: .:..:::.: : : :. . .::::.:.. : : :. CCDS95 VIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHDV 160 170 180 190 200 210 210 pF1KE1 LLMYT CCDS95 GETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT 220 230 240 250 >>CCDS34021.1 FGF5 gene_id:2250|Hs109|chr4 (268 aa) initn: 384 init1: 263 opt: 408 Z-score: 499.0 bits: 99.7 E(33420): 1.8e-21 Smith-Waterman score: 408; 48.3% identity (76.9% similar) in 143 aa overlap (65-203:87-227) 40 50 60 70 80 90 pF1KE1 PLLGERRSAAERSARGGPGAAQLAHLHGILRRRQLYCRTG--FHLQILPDGSVQGTRQDH : .::::.: ::::: :::.:.:. .. CCDS34 SSASSSPAASLGSQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGS-HEA 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE1 SLFGILEFISVAVGLVSIRGVDSGLYLGMNDKGELYGSEKLTSECIFREQFEENWYNTYS .....::...:. :.:.:::: :. .:.:. ::.:..: :.:..: :::.:.:: ::::. CCDS34 NMLSVLEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYA 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE1 SNIYKHGDTGRRYFVALNKDGTPRDGA--RSKRHQKFTHFLPRPVDPERVPELYKDLLMY : :.. :::...::::: : . : : : .. :::::: . :. ::: CCDS34 SAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPRFKQSEQ-PELSFTVTVP 180 190 200 210 220 230 pF1KE1 T CCDS34 EKKKPPSPIKPKIPLSAPRKNTNSVKYRLKFRFG 240 250 260 >>CCDS12037.1 FGF22 gene_id:27006|Hs109|chr19 (170 aa) initn: 409 init1: 302 opt: 402 Z-score: 494.5 bits: 98.2 E(33420): 3.3e-21 Smith-Waterman score: 402; 45.0% identity (72.8% similar) in 151 aa overlap (42-192:20-166) 20 30 40 50 60 70 pF1KE1 GGLEGLGQQVGSHFLLPPAGERPPLLGERRSAAERSARGGPGAAQLAHLHGILRRRQLYC .:. :: :: . ::.: .: :.:. CCDS12 MRRRLWLGLAWLLLARAPDAAGTPSASRGPRS--YPHLEGDVRWRRLFS 10 20 30 40 80 90 100 110 120 130 pF1KE1 RTGFHLQILPDGSVQGTRQDHSLFGILEFISVAVGLVSIRGVDSGLYLGMNDKGELYGSE : : :.. : : ::::: :. .:::. :: ::.: :..:.::.:..:: .:.::::. CCDS12 STHFFLRVDPGGRVQGTRWRHGQDSILEIRSVHVGVVVIKAVSSGFYVAMNRRGRLYGSR 50 60 70 80 90 100 140 150 160 170 180 190 pF1KE1 KLTSECIFREQFEENWYNTYSSNIYKHGDTGRRYFVALNKDGTPRDGARSKRHQKFTHFL : .: :::..::: .:::.:. ... :. .:.::.. : :: :.:..:.. .::: CCDS12 LYTVDCRFRERIEENGHNTYASQRWRR--RGQPMFLALDRRGGPRPGGRTRRYHLSAHFL 110 120 130 140 150 160 200 210 pF1KE1 PRPVDPERVPELYKDLLMYT : CCDS12 PVLVS 170 >>CCDS3950.1 FGF10 gene_id:2255|Hs109|chr5 (208 aa) initn: 391 init1: 292 opt: 401 Z-score: 492.0 bits: 98.0 E(33420): 4.5e-21 Smith-Waterman score: 401; 37.4% identity (71.3% similar) in 174 aa overlap (19-192:38-203) 10 20 30 40 pF1KE1 MAPLAEVGGFLGGLEGLGQQVGSHFLLPPAGERPPLLGERRSAAERSA : .:. .. : : . :.: : . CCDS39 HCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 RGGPGAAQLAHLHGILRRRQLYCRTGFHLQILPDGSVQGTRQDHSLFGILEFISVAVGLV :. ::.: .: :.:. : . :.: .:.:.::.... ..:::. :: .:.: CCDS39 RS------YNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGVV 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE1 SIRGVDSGLYLGMNDKGELYGSEKLTSECIFREQFEENWYNTYSSNIYKHGDTGRRYFVA ......:. ::.:: ::.::::......: ..:..::: ::::.: ..:. ::...:: CCDS39 AVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHN--GRQMYVA 130 140 150 160 170 170 180 190 200 210 pF1KE1 LNKDGTPRDGARSKRHQKFTHFLPRPVDPERVPELYKDLLMYT :: :.:: : ...:.. .:::: CCDS39 LNGKGAPRRGQKTRRKNTSAHFLPMVVHS 180 190 200 >>CCDS55512.1 FGF13 gene_id:2258|Hs109|chrX (199 aa) initn: 416 init1: 383 opt: 398 Z-score: 488.7 bits: 97.4 E(33420): 6.9e-21 Smith-Waterman score: 398; 40.0% identity (72.5% similar) in 160 aa overlap (54-211:14-170) 30 40 50 60 70 80 pF1KE1 HFLLPPAGERPPLLGERRSAAERSARGGPGAAQLAHLHGILRRRQLYCRTGFHLQILPDG :.. .:.::. . :: : :.:::. :: CCDS55 MSGKVTKPKEEKDASKEPQLKGIVTK--LYSRQGYHLQLQADG 10 20 30 40 90 100 110 120 130 140 pF1KE1 SVQGTRQDHSLFGILEFISVAVGLVSIRGVDSGLYLGMNDKGELYGSEKLTSECIFREQF ...::... : . ....: :.. .:.:.::.. :::.::..: :: :: .: :: :.:. CCDS55 TIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESV 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE1 EENWYNTYSSNIYKHGDTGRRYFVALNKDGTPRDGARSKRHQKFTHFLPRP--VDPERVP ::.: :::: ::.. ..:: ....:::.: : . :... .::::.: : . : CCDS55 FENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEP 110 120 130 140 150 160 210 pF1KE1 ELYKDLLMYT :. :: .. CCDS55 SLH-DLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST 170 180 190 >>CCDS14664.1 FGF13 gene_id:2258|Hs109|chrX (192 aa) initn: 416 init1: 383 opt: 394 Z-score: 484.1 bits: 96.5 E(33420): 1.2e-20 Smith-Waterman score: 394; 40.6% identity (72.9% similar) in 155 aa overlap (59-211:12-163) 30 40 50 60 70 80 pF1KE1 PAGERPPLLGERRSAAERSARGGPGAAQLAHLHGILRRRQLYCRTGFHLQILPDGSVQGT .:.::. . :: : :.:::. ::...:: CCDS14 MALLRKSYSEPQLKGIVTK--LYSRQGYHLQLQADGTIDGT 10 20 30 90 100 110 120 130 140 pF1KE1 RQDHSLFGILEFISVAVGLVSIRGVDSGLYLGMNDKGELYGSEKLTSECIFREQFEENWY ... : . ....: :.. .:.:.::.. :::.::..: :: :: .: :: :.:. ::.: CCDS14 KDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESVFENYY 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE1 NTYSSNIYKHGDTGRRYFVALNKDGTPRDGARSKRHQKFTHFLPRP--VDPERVPELYKD :::: ::.. ..:: ....:::.: : . :... .::::.: : . : :. : CCDS14 VTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLH-D 100 110 120 130 140 150 210 pF1KE1 LLMYT : .. CCDS14 LTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST 160 170 180 190 211 residues in 1 query sequences 18921897 residues in 33420 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Jun 19 14:26:49 2019 done: Wed Jun 19 14:26:49 2019 Total Scan time: 1.080 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]