FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1731, 239 aa 1>>>pF1KE1731 239 - 239 aa - 239 aa Library: human.CCDS.faa 18921897 residues in 33420 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4183+/-0.000609; mu= 15.2397+/- 0.037 mean_var=79.3508+/-15.666, 0's: 0 Z-trim(113.3): 35 B-trim: 0 in 0/52 Lambda= 0.143979 statistics sampled from 14079 (14114) to 14079 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.422), width: 16 Scan time: 1.200 The best scores are: opt bits E(33420) CCDS8195.1 FGF3 gene_id:2248|Hs109|chr11 ( 239) 1617 344.4 4e-95 CCDS34021.1 FGF5 gene_id:2250|Hs109|chr4 ( 268) 349 81.1 8.4e-16 CCDS12037.1 FGF22 gene_id:27006|Hs109|chr19 ( 170) 339 78.9 2.5e-15 CCDS3950.1 FGF10 gene_id:2255|Hs109|chr5 ( 208) 338 78.7 3.4e-15 CCDS9298.1 FGF9 gene_id:2254|Hs109|chr13 ( 208) 332 77.5 8e-15 CCDS5998.1 FGF20 gene_id:26281|Hs109|chr8 ( 211) 330 77.1 1.1e-14 CCDS75996.1 FGF16 gene_id:8823|Hs109|chrX ( 207) 324 75.8 2.5e-14 CCDS8527.1 FGF6 gene_id:2251|Hs109|chr12 ( 208) 299 70.6 9.2e-13 CCDS10131.1 FGF7 gene_id:2252|Hs109|chr15 ( 194) 282 67.1 1e-11 >>CCDS8195.1 FGF3 gene_id:2248|Hs109|chr11 (239 aa) initn: 1617 init1: 1617 opt: 1617 Z-score: 1821.5 bits: 344.4 E(33420): 4e-95 Smith-Waterman score: 1617; 100.0% identity (100.0% similar) in 239 aa overlap (1-239:1-239) 10 20 30 40 50 60 pF1KE1 MGLIWLLLLSLLEPGWPAAGPGARLRRDAGGRGGVYEHLGGAPRRRKLYCATKYHLQLHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MGLIWLLLLSLLEPGWPAAGPGARLRRDAGGRGGVYEHLGGAPRRRKLYCATKYHLQLHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SGRVNGSLENSAYSILEITAVEVGIVAIRGLFSGRYLAMNKRGRLYASEHYSAECEFVER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 SGRVNGSLENSAYSILEITAVEVGIVAIRGLFSGRYLAMNKRGRLYASEHYSAECEFVER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 IHELGYNTYASRLYRTVSSTPGARRQPSAERLWYVSVNGKGRPRRGFKTRRTQKSSLFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 IHELGYNTYASRLYRTVSSTPGARRQPSAERLWYVSVNGKGRPRRGFKTRRTQKSSLFLP 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 RVLDHRDHEMVRQLQSGLPRPPGKGVQPRRRRQKQSPDNLEPSHVQASRLGSQLEASAH ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 RVLDHRDHEMVRQLQSGLPRPPGKGVQPRRRRQKQSPDNLEPSHVQASRLGSQLEASAH 190 200 210 220 230 >>CCDS34021.1 FGF5 gene_id:2250|Hs109|chr4 (268 aa) initn: 368 init1: 312 opt: 349 Z-score: 397.4 bits: 81.1 E(33420): 8.4e-16 Smith-Waterman score: 404; 37.1% identity (67.0% similar) in 197 aa overlap (17-209:63-246) 10 20 30 40 pF1KE1 MGLIWLLLLSLLEPGWPAAGPGARLRRDAGGRGGVYEHLGGAPRRR :::. :.. .: . . .. .. : CCDS34 GPAATDRNPRGSSSRQSSSSAMSSSSASSSPAASLGSQ---GSGLEQSSFQWSPSGRRTG 40 50 60 70 80 50 60 70 80 90 100 pF1KE1 KLYC--ATKYHLQLHPSGRVNGSLENSAYSILEITAVEVGIVAIRGLFSGRYLAMNKRGR .::: . .:::..:.:.:::: : . :.::: :: :::.:::.::...:::.:.:. CCDS34 SLYCRVGIGFHLQIYPDGKVNGSHEANMLSVLEIFAVSQGIVGIRGVFSNKFLAMSKKGK 90 100 110 120 130 140 110 120 130 140 150 160 pF1KE1 LYASEHYSAECEFVERIHELGYNTYASRLYRTVSSTPGARRQPSAERLWYVSVNGKGRPR :.:: ... .:.: ::..: .:::::: ..:: .. : : :::..: .:. . CCDS34 LHASAKFTDDCKFRERFQENSYNTYASAIHRTEKT--G--------REWYVALNKRGKAK 150 160 170 180 190 170 180 190 200 210 220 pF1KE1 RGFKTR-RTQK-SSLFLPRVLDHRDHEMVRQLQSGLPRPPGKGVQPRRRRQKQSPDNLEP :: . : . :. :. :::: . .. :. . . : . ..:. CCDS34 RGCSPRVKPQHISTHFLPRFKQSEQPELSFTVTVPEKKKPPSPIKPKIPLSAPRKNTNSV 200 210 220 230 240 250 230 pF1KE1 SHVQASRLGSQLEASAH CCDS34 KYRLKFRFG 260 >>CCDS12037.1 FGF22 gene_id:27006|Hs109|chr19 (170 aa) initn: 352 init1: 234 opt: 339 Z-score: 388.9 bits: 78.9 E(33420): 2.5e-15 Smith-Waterman score: 392; 41.2% identity (65.9% similar) in 182 aa overlap (1-180:7-166) 10 20 30 40 50 pF1KE1 MGLIWLLLLSLLEP-GWPAAGPGARLRRDAGGRGGVYEHLGGAPRRRKLYCATK .:: :::: . : :.:. : : : :: : : :.:. .:. CCDS12 MRRRLWLGLAWLLLARAPDAAGTPSASRGPR----------SYPHLEGDVRWRRLFSSTH 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 YHLQLHPSGRVNGS-LENSAYSILEITAVEVGIVAIRGLFSGRYLAMNKRGRLYASEHYS . :.. :.:::.:. ... ::::: .:.::.:.:... :: :.:::.:::::.:. :. CCDS12 FFLRVDPGGRVQGTRWRHGQDSILEIRSVHVGVVVIKAVSSGFYVAMNRRGRLYGSRLYT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 AECEFVERIHELGYNTYASRLYRTVSSTPGARRQPSAERLWYVSVNGKGRPRRGFKTRRT ..:.: :::.: :.:::::. .: : :: ..... .: :: : .::: CCDS12 VDCRFRERIEENGHNTYASQRWRR-------RGQP-----MFLALDRRGGPRPGGRTRRY 120 130 140 150 180 190 200 210 220 230 pF1KE1 QKSSLFLPRVLDHRDHEMVRQLQSGLPRPPGKGVQPRRRRQKQSPDNLEPSHVQASRLGS . :. ::: CCDS12 HLSAHFLPVLVS 160 170 >>CCDS3950.1 FGF10 gene_id:2255|Hs109|chr5 (208 aa) initn: 448 init1: 252 opt: 338 Z-score: 386.6 bits: 78.7 E(33420): 3.4e-15 Smith-Waterman score: 422; 47.4% identity (71.2% similar) in 156 aa overlap (29-183:63-206) 10 20 30 40 50 pF1KE1 MGLIWLLLLSLLEPGWPAAGPGARLRRDAGGRGGVYEHLGGAPRRRKLYCATKYHLQL :: . :.:: : : :::. ::: :.. CCDS39 VPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKI 40 50 60 70 80 90 60 70 80 90 100 110 pF1KE1 HPSGRVNGSL-ENSAYSILEITAVEVGIVAIRGLFSGRYLAMNKRGRLYASEHYSAECEF . .:.:.:. :: :::::::.::.:.::.... :. ::::::.:.::.:.... .:.. CCDS39 EKNGKVSGTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKL 100 110 120 130 140 150 120 130 140 150 160 170 pF1KE1 VERIHELGYNTYASRLYRTVSSTPGARRQPSAERLWYVSVNGKGRPRRGFKTRRTQKSSL :::.: ::::::: .. . : ::..:::: :::: :::: . :. CCDS39 KERIEENGYNTYASFNWQHNG------------RQMYVALNGKGAPRRGQKTRRKNTSAH 160 170 180 190 200 180 190 200 210 220 230 pF1KE1 FLPRVLDHRDHEMVRQLQSGLPRPPGKGVQPRRRRQKQSPDNLEPSHVQASRLGSQLEAS ::: :. CCDS39 FLPMVVHS >>CCDS9298.1 FGF9 gene_id:2254|Hs109|chr13 (208 aa) initn: 429 init1: 210 opt: 332 Z-score: 379.8 bits: 77.5 E(33420): 8e-15 Smith-Waterman score: 418; 44.2% identity (71.2% similar) in 163 aa overlap (28-184:41-193) 10 20 30 40 50 pF1KE1 MGLIWLLLLSLLEPGWPAAGPGARLRRDAGG--RGGVY---EHLGGAPRRRKLYCAT .::: :: . .:: : :::.::: : CCDS92 FGVQDAVPFGNVPVLPVDSPVLLSDHLGQSEAGGLPRGPAVTDLDHLKGILRRRQLYCRT 20 30 40 50 60 70 60 70 80 90 100 110 pF1KE1 KYHLQLHPSGRVNGSLEN-SAYSILEITAVEVGIVAIRGLFSGRYLAMNKRGRLYASEHY .::.. :.: ..:. .. : ..:::. .. ::.:.:::. :: ::.::..:.::.::. CCDS92 GFHLEIFPNGTIQGTRKDHSRFGILEFISIAVGLVSIRGVDSGLYLGMNEKGELYGSEKL 80 90 100 110 120 130 120 130 140 150 160 170 pF1KE1 SAECEFVERIHELGYNTYASRLYRTVSSTPGARRQPSAERLWYVSVNGKGRPRRGFKTRR . :: : :...: ::::.: ::. :.. .:: .::..: : ::.: .:.: CCDS92 TQECVFREQFEENWYNTYSSNLYKHVDT---GRR-------YYVALNKDGTPREGTRTKR 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 TQKSSLFLPRVLDHRDHEMVRQLQSGLPRPPGKGVQPRRRRQKQSPDNLEPSHVQASRLG :: . :::: .: CCDS92 HQKFTHFLPRPVDPDKVPELYKDILSQS 190 200 >>CCDS5998.1 FGF20 gene_id:26281|Hs109|chr8 (211 aa) initn: 393 init1: 202 opt: 330 Z-score: 377.5 bits: 77.1 E(33420): 1.1e-14 Smith-Waterman score: 407; 41.9% identity (68.6% similar) in 172 aa overlap (26-194:46-207) 10 20 30 40 50 pF1KE1 MGLIWLLLLSLLEPGWPAAGPGARLRRDAGGRGGVY-EHLGGAPRRRKLYCATKY : :: :.. :: : :::.::: : . CCDS59 GLGQQVGSHFLLPPAGERPPLLGERRSAAERSARGGPGAAQLAHLHGILRRRQLYCRTGF 20 30 40 50 60 70 60 70 80 90 100 110 pF1KE1 HLQLHPSGRVNGSLEN-SAYSILEITAVEVGIVAIRGLFSGRYLAMNKRGRLYASEHYSA :::. :.: :.:. .. : ..:::. .: ::.:.:::. :: ::.:: .:.::.::. .. CCDS59 HLQILPDGSVQGTRQDHSLFGILEFISVAVGLVSIRGVDSGLYLGMNDKGELYGSEKLTS 80 90 100 110 120 130 120 130 140 150 160 170 pF1KE1 ECEFVERIHELGYNTYASRLYRTVSSTPGARRQPSAERLWYVSVNGKGRPRRGFKTRRTQ :: : :...: ::::.: .:. . .. : ..:..: : :: : ...: : CCDS59 ECIFREQFEENWYNTYSSNIYK----------HGDTGRRYFVALNKDGTPRDGARSKRHQ 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 KSSLFLPRVLD-HRDHEMVRQLQSGLPRPPGKGVQPRRRRQKQSPDNLEPSHVQASRLGS : . :::: .: .: :. ..: CCDS59 KFTHFLPRPVDPERVPELYKDLLMYT 190 200 210 >>CCDS75996.1 FGF16 gene_id:8823|Hs109|chrX (207 aa) initn: 430 init1: 204 opt: 324 Z-score: 370.9 bits: 75.8 E(33420): 2.5e-14 Smith-Waterman score: 423; 44.7% identity (72.7% similar) in 150 aa overlap (36-184:53-192) 10 20 30 40 50 60 pF1KE1 LLLLSLLEPGWPAAGPGARLRRDAGGRGGVYEHLGGAPRRRKLYCATKYHLQLHPSGRVN . :: : :::.::: : .::.. :.: :. CCDS75 GNVPLADSPGFLNERLGQIEGKLQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVH 30 40 50 60 70 80 70 80 90 100 110 120 pF1KE1 GSL-ENSAYSILEITAVEVGIVAIRGLFSGRYLAMNKRGRLYASEHYSAECEFVERIHEL :. ..: ..:::. .. ::...:::. :: ::.::.::.::.:.. . :: : :...: CCDS75 GTRHDHSRFGILEFISLAVGLISIRGVDSGLYLGMNERGELYGSKKLTRECVFREQFEEN 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE1 GYNTYASRLYRTVSSTPGARRQPSAERLWYVSVNGKGRPRRGFKTRRTQKSSLFLPRVLD :::::: ::. . ..:: .::..: : ::.:..:.: :: . :::: .: CCDS75 WYNTYASTLYK----------HSDSERQYYVALNKDGSPREGYRTKRHQKFTHFLPRPVD 150 160 170 180 190 190 200 210 220 230 pF1KE1 HRDHEMVRQLQSGLPRPPGKGVQPRRRRQKQSPDNLEPSHVQASRLGSQLEASAH CCDS75 PSKLPSMSRDLFHYR 200 >>CCDS8527.1 FGF6 gene_id:2251|Hs109|chr12 (208 aa) initn: 343 init1: 260 opt: 299 Z-score: 342.8 bits: 70.6 E(33420): 9.2e-13 Smith-Waterman score: 324; 35.0% identity (60.6% similar) in 180 aa overlap (5-182:54-208) 10 20 30 pF1KE1 MGLIWLLLLSLLEPGWPAAGPGARLRRDAGGRGG : ::: . : :: : . ..: CCDS85 ALVFLGILVGMVVPSPAGTRANNTLLDSRGWGTLLSRSRAG--LAGEIAGVNWESG---- 30 40 50 60 70 40 50 60 70 80 90 pF1KE1 VYEHLGGAPRRRKLYCATK--YHLQLHPSGRVNGSLENSAYSILEITAVEVGIVAIRGLF .: : :.:.::: . .:::. :.::..:. :.. ::.:::..:: :.:.. :. CCDS85 ---YLVGIKRQRRLYCNVGIGFHLQVLPDGRISGTHEENPYSLLEISTVERGVVSLFGVR 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE1 SGRYLAMNKRGRLYASEHYSAECEFVERIHELGYNTYASRLYRTVSSTPGARRQPSAERL :. ..:::..:::::. .. ::.: : . .::.: : ::. . CCDS85 SALFVAMNSKGRLYATPSFQEECKFRETLLPNNYNAYESDLYQGT--------------- 140 150 160 170 160 170 180 190 200 210 pF1KE1 WYVSVNGKGRPRRGFKTRRTQKSSLFLPRVLDHRDHEMVRQLQSGLPRPPGKGVQPRRRR :.... :: .:: :. . . ::::. CCDS85 -YIALSKYGRVKRGSKVSPIMTVTHFLPRI 180 190 200 >>CCDS10131.1 FGF7 gene_id:2252|Hs109|chr15 (194 aa) initn: 282 init1: 200 opt: 282 Z-score: 324.1 bits: 67.1 E(33420): 1e-11 Smith-Waterman score: 337; 42.2% identity (69.4% similar) in 147 aa overlap (36-180:56-190) 10 20 30 40 50 60 pF1KE1 LLLLSLLEPGWPAAGPGARLRRDAGGRGGVYEHL-GGAPRRRKLYCATKYHLQLHPSGRV :... :: : :.:.: :...:.. :.: CCDS10 GTISLACNDMTPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKV 30 40 50 60 70 80 70 80 90 100 110 120 pF1KE1 NGSLE-NSAYSILEITAVEVGIVAIRGLFSGRYLAMNKRGRLYASEHYSAECEFVERIHE .:. : .. :.:.:: .: ::::::.:. : ::::::.:.:::... . .:.: : : : CCDS10 KGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILE 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE1 LGYNTYASRLYRTVSSTPGARRQPSAERLWYVSVNGKGRPRRGFKTRRTQKSSLFLPRVL :::::: :. .. .. .:..: :: : :: ::.. ::.. ::: CCDS10 NHYNTYAS-----------AKWTHNGGEM-FVALNQKGIPVRGKKTKKEQKTAHFLPMAI 150 160 170 180 190 190 200 210 220 230 pF1KE1 DHRDHEMVRQLQSGLPRPPGKGVQPRRRRQKQSPDNLEPSHVQASRLGSQLEASAH CCDS10 T 239 residues in 1 query sequences 18921897 residues in 33420 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Jul 16 15:47:33 2019 done: Tue Jul 16 15:47:33 2019 Total Scan time: 1.200 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]