Result of FASTA (omim) for
pF1KE1747
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1747, 251 aa
1>>>pF1KE1747 251 - 251 aa - 251 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2528+/-0.000307; mu= 10.8331+/- 0.019
mean_var=95.5224+/-18.963, 0's: 0 Z-trim(119.6): 79 B-trim: 0 in 0/51
Lambda= 0.131227
statistics sampled from 33798 (33879) to 33798 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.764), E-opt: 0.2 (0.397), width: 16
Scan time: 5.960
The best scores are: opt bits E(85289)
NP_065689 (OMIM: 193100,605380) fibroblast growth ( 251) 1760 342.7 3.6e-94
NP_061986 (OMIM: 609436) fibroblast growth factor ( 209) 312 68.5 1e-11
NP_005108 (OMIM: 603891) fibroblast growth factor ( 216) 252 57.2 2.8e-08
NP_005238 (OMIM: 164950,610706) fibroblast growth ( 239) 224 51.9 1.2e-06
NP_004456 (OMIM: 149730,180920,602115) fibroblast ( 208) 203 47.9 1.7e-05
XP_005248321 (OMIM: 149730,180920,602115) PREDICTE ( 208) 203 47.9 1.7e-05
NP_001308876 (OMIM: 601515,609307) fibroblast grow ( 200) 188 45.0 0.00012
NP_001308877 (OMIM: 601515,609307) fibroblast grow ( 213) 188 45.1 0.00012
NP_001308874 (OMIM: 601515,609307) fibroblast grow ( 213) 188 45.1 0.00012
NP_001132973 (OMIM: 300070) fibroblast growth fact ( 226) 188 45.1 0.00013
NP_001132974 (OMIM: 300070) fibroblast growth fact ( 226) 188 45.1 0.00013
NP_003859 (OMIM: 300827,309630) fibroblast growth ( 207) 187 44.9 0.00014
NP_787125 (OMIM: 601515,609307) fibroblast growth ( 252) 188 45.1 0.00014
XP_005262456 (OMIM: 300070) PREDICTED: fibroblast ( 255) 188 45.1 0.00014
NP_001132972 (OMIM: 300070) fibroblast growth fact ( 255) 188 45.1 0.00014
NP_062825 (OMIM: 605558,615721) fibroblast growth ( 211) 186 44.7 0.00016
NP_001308867 (OMIM: 601515,609307) fibroblast grow ( 187) 184 44.3 0.00019
NP_001308869 (OMIM: 601515,609307) fibroblast grow ( 187) 184 44.3 0.00019
NP_001308862 (OMIM: 601515,609307) fibroblast grow ( 187) 184 44.3 0.00019
NP_001308865 (OMIM: 601515,609307) fibroblast grow ( 184) 181 43.7 0.00028
NP_001308873 (OMIM: 601515,609307) fibroblast grow ( 184) 181 43.7 0.00028
NP_001308861 (OMIM: 601515,609307) fibroblast grow ( 184) 181 43.7 0.00028
NP_001308870 (OMIM: 601515,609307) fibroblast grow ( 185) 181 43.7 0.00028
NP_066276 (OMIM: 134921) fibroblast growth factor ( 208) 181 43.7 0.0003
NP_001998 (OMIM: 164980) fibroblast growth factor ( 206) 180 43.5 0.00034
NP_004106 (OMIM: 601515,609307) fibroblast growth ( 247) 181 43.8 0.00035
XP_005247284 (OMIM: 601513,617166) PREDICTED: fibr ( 207) 177 43.0 0.00051
NP_378668 (OMIM: 300070) fibroblast growth factor ( 192) 176 42.8 0.00055
NP_004455 (OMIM: 165190,190330) fibroblast growth ( 268) 178 43.2 0.00056
NP_001132970 (OMIM: 300070) fibroblast growth fact ( 199) 176 42.8 0.00057
NP_002000 (OMIM: 148180) fibroblast growth factor ( 194) 175 42.6 0.00063
NP_004105 (OMIM: 300070) fibroblast growth factor ( 245) 176 42.8 0.00067
NP_002001 (OMIM: 600921,612961) fibroblast growth ( 208) 174 42.4 0.00076
XP_006713601 (OMIM: 601513,617166) PREDICTED: fibr ( 178) 170 41.6 0.0011
NP_004104 (OMIM: 601513,617166) fibroblast growth ( 181) 170 41.6 0.0011
NP_066360 (OMIM: 601513,617166) fibroblast growth ( 243) 170 41.7 0.0015
NP_065688 (OMIM: 605831) fibroblast growth factor ( 170) 157 39.1 0.006
>>NP_065689 (OMIM: 193100,605380) fibroblast growth fact (251 aa)
initn: 1760 init1: 1760 opt: 1760 Z-score: 1811.5 bits: 342.7 E(85289): 3.6e-94
Smith-Waterman score: 1760; 100.0% identity (100.0% similar) in 251 aa overlap (1-251:1-251)
10 20 30 40 50 60
pF1KE1 MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 ENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSRRNEIPLIHFNTPIPRRHTRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSRRNEIPLIHFNTPIPRRHTRS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 AEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTHAGGTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTHAGGTG
190 200 210 220 230 240
250
pF1KE1 PEGCRPFAKFI
:::::::::::
NP_065 PEGCRPFAKFI
250
>>NP_061986 (OMIM: 609436) fibroblast growth factor 21 p (209 aa)
initn: 279 init1: 228 opt: 312 Z-score: 331.2 bits: 68.5 E(85289): 1e-11
Smith-Waterman score: 312; 32.2% identity (57.6% similar) in 205 aa overlap (8-205:13-209)
10 20 30 40 50
pF1KE1 MLGARLRLWVCALCSVCSMSVLRAYP--NASPLLGSSWGGLI---HLYTATARNS
::: .: .. ... .:.: ..:::: ..:: . .::: :...
NP_061 MDSDETGFEHSGLWVSVLAGLL-LGACQAHPIPDSSPLL--QFGGQVRQRYLYTDDAQQT
10 20 30 40 50
60 70 80 90 100
pF1KE1 Y-HLQIHKNGHVDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFD
::.:...: : :: :. : :.... : . : :: . :.::. : ..:: .::
NP_061 EAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFD
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 PENCRFQHQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSRRNEIPLIHF
:: : :.. ::.::.::.: . . . : : : .: : . .: .: .
NP_061 PEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKS---PHRDPAPRGP--ARFLPLPGLPP
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 NTPIPRRHTRSAEDD-SERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVR
: : : . :::... : .:. ::
NP_061 ALPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS
180 190 200
230 240 250
pF1KE1 GGRVNTHAGGTGPEGCRPFAKFI
>>NP_005108 (OMIM: 603891) fibroblast growth factor 19 p (216 aa)
initn: 208 init1: 180 opt: 252 Z-score: 269.6 bits: 57.2 E(85289): 2.8e-08
Smith-Waterman score: 252; 31.4% identity (56.5% similar) in 191 aa overlap (6-190:8-192)
10 20 30 40 50
pF1KE1 MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLI---HLYTATAR--NSYHL
...:. : . . :. .:.: . .:: : ::::. . .: :
NP_005 MRSGCVVVHVWILAGLWLAVAGRPLAFSDAGPHVHYGWGDPIRLRHLYTSGPHGLSSCFL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 QIHKNGHVDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENC
.:. .: :: : :. .: : :.. :.: :: : ::::: :.. : .. :.:
NP_005 RIRADGVVDCARGQSAHSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQYSEEDC
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 RFQHQTLENGYDVYHSPQYHFLVSLGRAK-RAFLPGMNPPPYSQFLSRRNEIPLIHFNTP
:... .::.::.: .... :::. :: : . . . : :.:: .:.. .
NP_005 AFEEEIRPDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFLPLSHFLPM---LPMVPEEPE
130 140 150 160 170
180 190 200 210 220 230
pF1KE1 IPRRHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRV
: : :.: .::
NP_005 DLRGHL---ESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEK
180 190 200 210
>>NP_005238 (OMIM: 164950,610706) fibroblast growth fact (239 aa)
initn: 188 init1: 170 opt: 224 Z-score: 240.3 bits: 51.9 E(85289): 1.2e-06
Smith-Waterman score: 234; 31.5% identity (60.7% similar) in 168 aa overlap (42-198:48-211)
20 30 40 50 60 70
pF1KE1 ALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGHVDGAPHQTIYS
:: :: .::::.: .:.:.:. ... ::
NP_005 AAGPGARLRRDAGGRGGVYEHLGGAPRRRKLYCAT---KYHLQLHPSGRVNGSLENSAYS
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE1 ALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTLENGYDVYHSPQ
: : . ..:.:.: :..: ::: :. :: ...:.... : :.: .. : ::..: :
NP_005 ILEITAVEVGIVAIRGLFSGRYLAMNKRGRLYASEHYSAE-CEFVERIHELGYNTYASRL
80 90 100 110 120 130
140 150 160 170 180
pF1KE1 YHFLVSLGRAKRA------FLPGMNPP--PYSQFLSRRNEIPLIHFNTPIPRR-H--TRS
:. . : :.: . ..: : : .::.. . . . .: : .:.
NP_005 YRTVSSTPGARRQPSAERLWYVSVNGKGRPRRGFKTRRTQKSSLFLPRVLDHRDHEMVRQ
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE1 AEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTHAGGTG
.. : : . ..:: :
NP_005 LQSGLPRPPGKGVQPRRRRQKQSPDNLEPSHVQASRLGSQLEASAH
200 210 220 230
>>NP_004456 (OMIM: 149730,180920,602115) fibroblast grow (208 aa)
initn: 144 init1: 97 opt: 203 Z-score: 219.7 bits: 47.9 E(85289): 1.7e-05
Smith-Waterman score: 203; 33.6% identity (65.5% similar) in 113 aa overlap (51-162:88-196)
30 40 50 60 70
pF1KE1 VLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGHVDGAPHQTI-YSALMIRSED
: :.:.:::.:.:. ... :: : : : .
NP_004 SSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVE
60 70 80 90 100 110
80 90 100 110 120 130
pF1KE1 AGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTLENGYDVYHSPQYHFLVSLG
: :.. .. : :: :. .:...::. :. ..:..... ::::..: : ... :
NP_004 IGVVAVKAINSNYYLAMNKKGKLYGSKEFN-NDCKLKERIEENGYNTYASFNWQH---NG
120 130 140 150 160 170
140 150 160 170 180 190
pF1KE1 RAKRAFLPGMNPPPYSQFLSRRNEIPLIHFNTPIPRRHTRSAEDDSERDPLNVLKPRARM
: . : : . : .: :.:
NP_004 RQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS
180 190 200
>>XP_005248321 (OMIM: 149730,180920,602115) PREDICTED: f (208 aa)
initn: 144 init1: 97 opt: 203 Z-score: 219.7 bits: 47.9 E(85289): 1.7e-05
Smith-Waterman score: 203; 33.6% identity (65.5% similar) in 113 aa overlap (51-162:88-196)
30 40 50 60 70
pF1KE1 VLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGHVDGAPHQTI-YSALMIRSED
: :.:.:::.:.:. ... :: : : : .
XP_005 SSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVE
60 70 80 90 100 110
80 90 100 110 120 130
pF1KE1 AGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTLENGYDVYHSPQYHFLVSLG
: :.. .. : :: :. .:...::. :. ..:..... ::::..: : ... :
XP_005 IGVVAVKAINSNYYLAMNKKGKLYGSKEFN-NDCKLKERIEENGYNTYASFNWQH---NG
120 130 140 150 160 170
140 150 160 170 180 190
pF1KE1 RAKRAFLPGMNPPPYSQFLSRRNEIPLIHFNTPIPRRHTRSAEDDSERDPLNVLKPRARM
: . : : . : .: :.:
XP_005 RQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS
180 190 200
>>NP_001308876 (OMIM: 601515,609307) fibroblast growth f (200 aa)
initn: 88 init1: 72 opt: 188 Z-score: 204.6 bits: 45.0 E(85289): 0.00012
Smith-Waterman score: 188; 28.1% identity (56.8% similar) in 199 aa overlap (14-210:4-187)
10 20 30 40 50 60
pF1KE1 MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGH
: .:. :. . ..: : : . .:: :..:.::.: .:
NP_001 MLQC-LCGKSLKKNKNPTDPQLK---GIVTRLY---CRQGYYLQMHPDGA
10 20 30 40
70 80 90 100 110
pF1KE1 VDGAPHQTIYSALM-IRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQT
.::. .. :.:. . :.: :: . :. :. .: .. :. : :: :.:....
NP_001 LDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPE-CKFKESV
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 LENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSR-RNEIPLIHFNTPIPRRHT
.:: : .: : :. : ::: :: :.: .. .: .. : :: : : . .
NP_001 FENYYVIYSSMLYRQQES-GRAW--FL-GLNKEGQAMKGNRVKKTKPAAHF-LPKPLE-V
110 120 130 140 150
180 190 200 210 220 230
pF1KE1 RSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTHAGG
.. : .: .. :. .::. .. .. .
NP_001 AMYREPSLHD-VGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT
160 170 180 190 200
240 250
pF1KE1 TGPEGCRPFAKFI
>>NP_001308877 (OMIM: 601515,609307) fibroblast growth f (213 aa)
initn: 88 init1: 72 opt: 188 Z-score: 204.2 bits: 45.1 E(85289): 0.00012
Smith-Waterman score: 188; 28.1% identity (56.8% similar) in 199 aa overlap (14-210:17-200)
10 20 30 40 50
pF1KE1 MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHK
: .:. :. . ..: : : . .:: :..:.::.:
NP_001 MWFLWNIFSKGTHMLQC-LCGKSLKKNKNPTDPQLK---GIVTRLY---CRQGYYLQMHP
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 NGHVDGAPHQTIYSALM-IRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQ
.: .::. .. :.:. . :.: :: . :. :. .: .. :. : :: :.:.
NP_001 DGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPE-CKFK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 HQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSR-RNEIPLIHFNTPIPR
....:: : .: : :. : ::: :: :.: .. .: .. : :: : :
NP_001 ESVFENYYVIYSSMLYRQQES-GRAW--FL-GLNKEGQAMKGNRVKKTKPAAHF-LPKPL
120 130 140 150 160
180 190 200 210 220 230
pF1KE1 RHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTH
. . .. : .: .. :. .::. .. .. .
NP_001 E-VAMYREPSLHD-VGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT
170 180 190 200 210
240 250
pF1KE1 AGGTGPEGCRPFAKFI
>>NP_001308874 (OMIM: 601515,609307) fibroblast growth f (213 aa)
initn: 88 init1: 72 opt: 188 Z-score: 204.2 bits: 45.1 E(85289): 0.00012
Smith-Waterman score: 188; 28.1% identity (56.8% similar) in 199 aa overlap (14-210:17-200)
10 20 30 40 50
pF1KE1 MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHK
: .:. :. . ..: : : . .:: :..:.::.:
NP_001 MWFLWNIFSKGTHMLQC-LCGKSLKKNKNPTDPQLK---GIVTRLY---CRQGYYLQMHP
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 NGHVDGAPHQTIYSALM-IRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQ
.: .::. .. :.:. . :.: :: . :. :. .: .. :. : :: :.:.
NP_001 DGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPE-CKFK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 HQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSR-RNEIPLIHFNTPIPR
....:: : .: : :. : ::: :: :.: .. .: .. : :: : :
NP_001 ESVFENYYVIYSSMLYRQQES-GRAW--FL-GLNKEGQAMKGNRVKKTKPAAHF-LPKPL
120 130 140 150 160
180 190 200 210 220 230
pF1KE1 RHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTH
. . .. : .: .. :. .::. .. .. .
NP_001 E-VAMYREPSLHD-VGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT
170 180 190 200 210
240 250
pF1KE1 AGGTGPEGCRPFAKFI
>>NP_001132973 (OMIM: 300070) fibroblast growth factor 1 (226 aa)
initn: 177 init1: 79 opt: 188 Z-score: 203.8 bits: 45.1 E(85289): 0.00013
Smith-Waterman score: 188; 26.9% identity (55.7% similar) in 167 aa overlap (11-174:23-179)
10 20 30 40
pF1KE1 MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATAR
: : .. .. :. : . : . .::. :
NP_001 MLRQDSIQSAELKKKESPFRAKCHEIFCCPLKQVHHKENTEPEEPQLKGIVTKLYS---R
10 20 30 40 50
50 60 70 80 90 100
pF1KE1 NSYHLQIHKNGHVDGAPHQ-TIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHY
..::::.. .: .::. . . :. . . :.: ::... :: :. .: .. :.
NP_001 QGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSEL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 FDPENCRFQHQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPP--YSQFLSRRNEIP
: :: :.:.....:: : .: : :. .. :.. :.: .. ..:. :
NP_001 FTPE-CKFKESVFENYYVTYSSMIYR----QQQSGRGWYLGLNKEGEIMKGNHVKKNK-P
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 LIHFNTPIPRRHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLG
:: : :
NP_001 AAHF-LPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST
180 190 200 210 220
251 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 14:57:58 2016 done: Sun Nov 6 14:57:59 2016
Total Scan time: 5.960 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]