FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1761, 268 aa 1>>>pF1KE1761 268 - 268 aa - 268 aa Library: /omim/omim.rfq.tfa 65089639 residues in 91964 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.9796+/-0.00042; mu= 9.7467+/- 0.026 mean_var=285.8778+/-59.426, 0's: 0 Z-trim(120.3): 181 B-trim: 917 in 2/53 Lambda= 0.075855 statistics sampled from 36477 (36750) to 36477 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.727), E-opt: 0.2 (0.4), width: 16 Scan time: 3.390 The best scores are: opt bits E(91964) NP_001289561 (OMIM: 114170) calpain small subunit ( 268) 1826 212.8 5.8e-55 NP_001740 (OMIM: 114170) calpain small subunit 1 i ( 268) 1826 212.8 5.8e-55 NP_001003962 (OMIM: 114170) calpain small subunit ( 268) 1826 212.8 5.8e-55 XP_005259352 (OMIM: 114170) calpain small subunit ( 322) 1769 206.7 4.9e-53 XP_005259353 (OMIM: 114170) calpain small subunit ( 322) 1769 206.7 4.9e-53 XP_024307500 (OMIM: 114170) calpain small subunit ( 205) 1346 160.1 3.3e-39 XP_011525661 (OMIM: 114170) calpain small subunit ( 200) 1341 159.5 4.8e-39 NP_115706 (OMIM: 616767) calpain small subunit 2 [ ( 248) 1117 135.1 1.3e-31 NP_001289562 (OMIM: 114170) calpain small subunit ( 156) 1052 127.7 1.4e-29 NP_775111 (OMIM: 114240,253600,618129) calpain-3 i ( 309) 753 95.5 1.4e-19 NP_077320 (OMIM: 114240,253600,618129) calpain-3 i ( 815) 753 96.1 2.3e-19 NP_000061 (OMIM: 114240,253600,618129) calpain-3 i ( 821) 753 96.1 2.4e-19 NP_775110 (OMIM: 114240,253600,618129) calpain-3 i ( 729) 749 95.6 3e-19 NP_775113 (OMIM: 114240,253600,618129) calpain-3 i ( 156) 655 84.3 1.7e-16 NP_775112 (OMIM: 114240,253600,618129) calpain-3 i ( 156) 655 84.3 1.7e-16 NP_001185798 (OMIM: 114220,616907) calpain-1 catal ( 714) 634 83.0 1.8e-15 NP_001185797 (OMIM: 114220,616907) calpain-1 catal ( 714) 634 83.0 1.8e-15 XP_006718761 (OMIM: 114220,616907) calpain-1 catal ( 714) 634 83.0 1.8e-15 NP_005177 (OMIM: 114220,616907) calpain-1 catalyti ( 714) 634 83.0 1.8e-15 XP_011543594 (OMIM: 114220,616907) calpain-1 catal ( 714) 634 83.0 1.8e-15 NP_001139540 (OMIM: 114230) calpain-2 catalytic su ( 622) 606 79.8 1.4e-14 NP_001739 (OMIM: 114230) calpain-2 catalytic subun ( 700) 606 79.9 1.5e-14 XP_016855588 (OMIM: 606401) calpain-9 isoform X6 [ ( 495) 557 74.3 5.2e-13 NP_001306605 (OMIM: 606401) calpain-9 isoform 3 [H ( 627) 557 74.5 5.9e-13 NP_057536 (OMIM: 606401) calpain-9 isoform 2 [Homo ( 664) 557 74.5 6e-13 NP_006606 (OMIM: 606401) calpain-9 isoform 1 [Homo ( 690) 557 74.5 6.2e-13 NP_008989 (OMIM: 604822) calpain-11 [Homo sapiens] ( 739) 525 71.1 7.2e-12 XP_006715047 (OMIM: 604822) calpain-11 isoform X1 ( 740) 525 71.1 7.2e-12 XP_011512577 (OMIM: 604822) calpain-11 isoform X4 ( 743) 525 71.1 7.3e-12 XP_011512576 (OMIM: 604822) calpain-11 isoform X3 ( 744) 525 71.1 7.3e-12 XP_024308282 (OMIM: 606401) calpain-9 isoform X7 [ ( 403) 503 68.3 2.8e-11 XP_024308281 (OMIM: 606401) calpain-9 isoform X7 [ ( 403) 503 68.3 2.8e-11 XP_011542322 (OMIM: 606401) calpain-9 isoform X5 [ ( 526) 503 68.5 3.2e-11 XP_011542321 (OMIM: 606401) calpain-9 isoform X4 [ ( 658) 503 68.6 3.6e-11 XP_016855587 (OMIM: 606401) calpain-9 isoform X3 [ ( 693) 503 68.6 3.7e-11 XP_011542320 (OMIM: 606401) calpain-9 isoform X2 [ ( 695) 503 68.6 3.7e-11 XP_011542319 (OMIM: 606401) calpain-9 isoform X1 [ ( 721) 503 68.7 3.8e-11 XP_006715048 (OMIM: 604822) calpain-11 isoform X2 ( 724) 448 62.7 2.5e-09 NP_944490 (OMIM: 182520) sorcin isoform B [Homo sa ( 183) 359 52.0 1e-06 NP_003121 (OMIM: 182520) sorcin isoform A [Homo sa ( 198) 359 52.0 1.1e-06 NP_001243821 (OMIM: 182520) sorcin isoform D [Homo ( 180) 346 50.5 2.7e-06 NP_036330 (OMIM: 607030) grancalcin isoform b [Hom ( 217) 347 50.8 2.8e-06 NP_001243820 (OMIM: 182520) sorcin isoform C [Homo ( 195) 346 50.6 2.8e-06 XP_016860755 (OMIM: 610228) calpain-13 isoform X2 ( 665) 351 52.0 3.7e-06 XP_016860753 (OMIM: 610228) calpain-13 isoform X1 ( 669) 351 52.0 3.7e-06 XP_011531462 (OMIM: 610228) calpain-13 isoform X1 ( 669) 351 52.0 3.7e-06 XP_011531461 (OMIM: 610228) calpain-13 isoform X1 ( 669) 351 52.0 3.7e-06 NP_653176 (OMIM: 610228) calpain-13 [Homo sapiens] ( 669) 351 52.0 3.7e-06 XP_011531463 (OMIM: 610228) calpain-13 isoform X1 ( 669) 351 52.0 3.7e-06 NP_001317200 (OMIM: 607030) grancalcin isoform d [ ( 198) 339 49.8 4.8e-06 >>NP_001289561 (OMIM: 114170) calpain small subunit 1 is (268 aa) initn: 1826 init1: 1826 opt: 1826 Z-score: 1108.3 bits: 212.8 E(91964): 5.8e-55 Smith-Waterman score: 1826; 100.0% identity (100.0% similar) in 268 aa overlap (1-268:1-268) 10 20 30 40 50 60 pF1KE1 MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF 190 200 210 220 230 240 250 260 pF1KE1 RAFKSLDKDGTGQIQVNIQEWLQLTMYS :::::::::::::::::::::::::::: NP_001 RAFKSLDKDGTGQIQVNIQEWLQLTMYS 250 260 >>NP_001740 (OMIM: 114170) calpain small subunit 1 isofo (268 aa) initn: 1826 init1: 1826 opt: 1826 Z-score: 1108.3 bits: 212.8 E(91964): 5.8e-55 Smith-Waterman score: 1826; 100.0% identity (100.0% similar) in 268 aa overlap (1-268:1-268) 10 20 30 40 50 60 pF1KE1 MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF 190 200 210 220 230 240 250 260 pF1KE1 RAFKSLDKDGTGQIQVNIQEWLQLTMYS :::::::::::::::::::::::::::: NP_001 RAFKSLDKDGTGQIQVNIQEWLQLTMYS 250 260 >>NP_001003962 (OMIM: 114170) calpain small subunit 1 is (268 aa) initn: 1826 init1: 1826 opt: 1826 Z-score: 1108.3 bits: 212.8 E(91964): 5.8e-55 Smith-Waterman score: 1826; 100.0% identity (100.0% similar) in 268 aa overlap (1-268:1-268) 10 20 30 40 50 60 pF1KE1 MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF 190 200 210 220 230 240 250 260 pF1KE1 RAFKSLDKDGTGQIQVNIQEWLQLTMYS :::::::::::::::::::::::::::: NP_001 RAFKSLDKDGTGQIQVNIQEWLQLTMYS 250 260 >>XP_005259352 (OMIM: 114170) calpain small subunit 1 is (322 aa) initn: 1769 init1: 1769 opt: 1769 Z-score: 1073.8 bits: 206.7 E(91964): 4.9e-53 Smith-Waterman score: 1769; 100.0% identity (100.0% similar) in 260 aa overlap (1-260:1-260) 10 20 30 40 50 60 pF1KE1 MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF 190 200 210 220 230 240 250 260 pF1KE1 RAFKSLDKDGTGQIQVNIQEWLQLTMYS :::::::::::::::::::: XP_005 RAFKSLDKDGTGQIQVNIQEVRTPILGYGCLGGPHPSALHTSSELQSPSSYFASRPWVRA 250 260 270 280 290 300 >>XP_005259353 (OMIM: 114170) calpain small subunit 1 is (322 aa) initn: 1769 init1: 1769 opt: 1769 Z-score: 1073.8 bits: 206.7 E(91964): 4.9e-53 Smith-Waterman score: 1769; 100.0% identity (100.0% similar) in 260 aa overlap (1-260:1-260) 10 20 30 40 50 60 pF1KE1 MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF 190 200 210 220 230 240 250 260 pF1KE1 RAFKSLDKDGTGQIQVNIQEWLQLTMYS :::::::::::::::::::: XP_005 RAFKSLDKDGTGQIQVNIQEVRTPILGYGCLGGPHPSALHTSSELQSPSSYFASRPWVRA 250 260 270 280 290 300 >>XP_024307500 (OMIM: 114170) calpain small subunit 1 is (205 aa) initn: 1346 init1: 1346 opt: 1346 Z-score: 825.5 bits: 160.1 E(91964): 3.3e-39 Smith-Waterman score: 1346; 98.5% identity (99.5% similar) in 202 aa overlap (67-268:4-205) 40 50 60 70 80 90 pF1KE1 GGGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESE .: .:::::::::::::::::::::::::: XP_024 MKGTATNEAAAQYNPEPPPPRTHYSNIEANESE 10 20 30 100 110 120 130 140 150 pF1KE1 EVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 EVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTT 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE1 GKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 GKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRR 100 110 120 130 140 150 220 230 240 250 260 pF1KE1 YSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 YSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 160 170 180 190 200 >>XP_011525661 (OMIM: 114170) calpain small subunit 1 is (200 aa) initn: 1341 init1: 1341 opt: 1341 Z-score: 822.6 bits: 159.5 E(91964): 4.8e-39 Smith-Waterman score: 1341; 99.0% identity (100.0% similar) in 200 aa overlap (69-268:1-200) 40 50 60 70 80 90 pF1KE1 GGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEV ..:::::::::::::::::::::::::::: XP_011 MGEAAAQYNPEPPPPRTHYSNIEANESEEV 10 20 30 100 110 120 130 140 150 pF1KE1 RQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGK 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE1 LGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYS 100 110 120 130 140 150 220 230 240 250 260 pF1KE1 DESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 160 170 180 190 200 >>NP_115706 (OMIM: 616767) calpain small subunit 2 [Homo (248 aa) initn: 1068 init1: 1068 opt: 1117 Z-score: 689.3 bits: 135.1 E(91964): 1.3e-31 Smith-Waterman score: 1122; 67.2% identity (86.4% similar) in 250 aa overlap (20-268:10-248) 10 20 30 40 50 60 pF1KE1 MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR : :::..::::. :::: ::: . :: NP_115 MFLAKALLEGADRGLGEALGGLF-------GGGGQRREGGGRNIGG---- 10 20 30 70 80 90 100 110 pF1KE1 ILGGVISAISEAAA-QYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATE :.::... :::::: ::.::::: . :....::.::::::.::. :.:::: ::::.::. NP_115 IVGGIVNFISEAAAAQYTPEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATD 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE1 LMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYK ::::::::...: :::::::..:::::.:.:::::::::::::::::::::::.:: .:: NP_115 LMNILNKVLSKHKDLKTDGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYK 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE1 QFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAM :.: :.::.. ::.: ::..::::.:::.::.::.:::..:.:.:::.:::::::::::: NP_115 QYDRDHSGSLGSSQLRGALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAM 160 170 180 190 200 210 240 250 260 pF1KE1 FRAFKSLDKDGTGQIQVNIQEWLQLTMYS ::::::::.: : :::.:.::::::::: NP_115 FRAFKSLDRDRDGLIQVSIKEWLQLTMYS 220 230 240 >>NP_001289562 (OMIM: 114170) calpain small subunit 1 is (156 aa) initn: 1052 init1: 1052 opt: 1052 Z-score: 652.7 bits: 127.7 E(91964): 1.4e-29 Smith-Waterman score: 1052; 100.0% identity (100.0% similar) in 156 aa overlap (113-268:1-156) 90 100 110 120 130 140 pF1KE1 PRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGID :::::::::::::::::::::::::::::: NP_001 MEVSATELMNILNKVVTRHPDLKTDGFGID 10 20 30 150 160 170 180 190 200 pF1KE1 TCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAG 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE1 FHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWL 100 110 120 130 140 150 pF1KE1 QLTMYS :::::: NP_001 QLTMYS >>NP_775111 (OMIM: 114240,253600,618129) calpain-3 isofo (309 aa) initn: 818 init1: 744 opt: 753 Z-score: 473.1 bits: 95.5 E(91964): 1.4e-19 Smith-Waterman score: 753; 54.6% identity (80.9% similar) in 194 aa overlap (75-268:122-309) 50 60 70 80 90 100 pF1KE1 GGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRL . .:.: : . .:::: .::: . NP_775 FVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSD------QESEEQQQFRNI 100 110 120 130 140 110 120 130 140 150 160 pF1KE1 FAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEF : :.::::::. : :: ..:: ::..: :::: :: ...::::.:.::.: .:::...:: NP_775 FKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEF 150 160 170 180 190 200 170 180 190 200 210 220 pF1KE1 KYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNM ..:::.:: :: :.:..:::.:::: : :. .: . ::::::..::..: ::.:. :. NP_775 HHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNI 210 220 230 240 250 260 230 240 250 260 pF1KE1 DFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS :::.:: :.:::..:::::...:::: : :..:. ::::::::. NP_775 DFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 270 280 290 300 268 residues in 1 query sequences 65089639 residues in 91964 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Oct 23 17:42:02 2018 done: Tue Oct 23 17:42:03 2018 Total Scan time: 3.390 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]