Result of FASTA (omim) for
pF1KE1803
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1803, 317 aa
1>>>pF1KE1803 317 - 317 aa - 317 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.4551+/-0.000296; mu= 7.6255+/- 0.019
mean_var=127.5627+/-25.665, 0's: 0 Z-trim(121.5): 13 B-trim: 261 in 1/57
Lambda= 0.113557
statistics sampled from 38295 (38308) to 38295 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.765), E-opt: 0.2 (0.449), width: 16
Scan time: 7.420
The best scores are: opt bits E(85289)
NP_003692 (OMIM: 259710,602642) tumor necrosis fac ( 317) 2157 363.7 2.8e-100
XP_016876291 (OMIM: 259710,602642) PREDICTED: tumo ( 263) 1650 280.6 2.4e-75
XP_011533582 (OMIM: 259710,602642) PREDICTED: tumo ( 244) 1640 278.9 7.1e-75
XP_016876292 (OMIM: 259710,602642) PREDICTED: tumo ( 244) 1640 278.9 7.1e-75
NP_143026 (OMIM: 259710,602642) tumor necrosis fac ( 244) 1640 278.9 7.1e-75
NP_003801 (OMIM: 603598) tumor necrosis factor lig ( 281) 318 62.4 1.3e-09
NP_001191273 (OMIM: 604052) tumor necrosis factor ( 192) 206 44.0 0.0003
NP_005109 (OMIM: 604052) tumor necrosis factor lig ( 251) 206 44.0 0.00038
XP_016882906 (OMIM: 604520) PREDICTED: tumor necro ( 240) 179 39.6 0.0079
NP_003798 (OMIM: 604520) tumor necrosis factor lig ( 240) 179 39.6 0.0079
NP_742011 (OMIM: 604520) tumor necrosis factor lig ( 204) 177 39.2 0.0086
>>NP_003692 (OMIM: 259710,602642) tumor necrosis factor (317 aa)
initn: 2157 init1: 2157 opt: 2157 Z-score: 1921.3 bits: 363.7 E(85289): 2.8e-100
Smith-Waterman score: 2157; 100.0% identity (100.0% similar) in 317 aa overlap (1-317:1-317)
10 20 30 40 50 60
pF1KE1 MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 QAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 KVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 YVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLD
250 260 270 280 290 300
310
pF1KE1 PDQDATYFGAFKVRDID
:::::::::::::::::
NP_003 PDQDATYFGAFKVRDID
310
>>XP_016876291 (OMIM: 259710,602642) PREDICTED: tumor ne (263 aa)
initn: 1642 init1: 1642 opt: 1650 Z-score: 1473.6 bits: 280.6 E(85289): 2.4e-75
Smith-Waterman score: 1650; 98.4% identity (98.8% similar) in 250 aa overlap (68-317:14-263)
40 50 60 70 80 90
pF1KE1 PHQPPAASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENA
: : .::::::::::::::::::::::::
XP_016 MRGSTKKTDDTSDFKFCLEMDPNRISEDGTHCIYRILRLHENA
10 20 30 40
100 110 120 130 140 150
pF1KE1 DFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKR
50 60 70 80 90 100
160 170 180 190 200 210
pF1KE1 SKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLY
110 120 130 140 150 160
220 230 240 250 260 270
pF1KE1 ANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINV
170 180 190 200 210 220
280 290 300 310
pF1KE1 GGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
::::::::::::::::::::::::::::::::::::::::
XP_016 GGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
230 240 250 260
>>XP_011533582 (OMIM: 259710,602642) PREDICTED: tumor ne (244 aa)
initn: 1640 init1: 1640 opt: 1640 Z-score: 1465.3 bits: 278.9 E(85289): 7.1e-75
Smith-Waterman score: 1640; 100.0% identity (100.0% similar) in 244 aa overlap (74-317:1-244)
50 60 70 80 90 100
pF1KE1 ASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTT
::::::::::::::::::::::::::::::
XP_011 MDPNRISEDGTHCIYRILRLHENADFQDTT
10 20 30
110 120 130 140 150 160
pF1KE1 LESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQ
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE1 PFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFR
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE1 HHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKL
160 170 180 190 200 210
290 300 310
pF1KE1 RSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
::::::::::::::::::::::::::::::::::
XP_011 RSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
220 230 240
>>XP_016876292 (OMIM: 259710,602642) PREDICTED: tumor ne (244 aa)
initn: 1640 init1: 1640 opt: 1640 Z-score: 1465.3 bits: 278.9 E(85289): 7.1e-75
Smith-Waterman score: 1640; 100.0% identity (100.0% similar) in 244 aa overlap (74-317:1-244)
50 60 70 80 90 100
pF1KE1 ASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTT
::::::::::::::::::::::::::::::
XP_016 MDPNRISEDGTHCIYRILRLHENADFQDTT
10 20 30
110 120 130 140 150 160
pF1KE1 LESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQ
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE1 PFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFR
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE1 HHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKL
160 170 180 190 200 210
290 300 310
pF1KE1 RSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
::::::::::::::::::::::::::::::::::
XP_016 RSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
220 230 240
>>NP_143026 (OMIM: 259710,602642) tumor necrosis factor (244 aa)
initn: 1640 init1: 1640 opt: 1640 Z-score: 1465.3 bits: 278.9 E(85289): 7.1e-75
Smith-Waterman score: 1640; 100.0% identity (100.0% similar) in 244 aa overlap (74-317:1-244)
50 60 70 80 90 100
pF1KE1 ASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTT
::::::::::::::::::::::::::::::
NP_143 MDPNRISEDGTHCIYRILRLHENADFQDTT
10 20 30
110 120 130 140 150 160
pF1KE1 LESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_143 LESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQ
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE1 PFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_143 PFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFR
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE1 HHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_143 HHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKL
160 170 180 190 200 210
290 300 310
pF1KE1 RSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
::::::::::::::::::::::::::::::::::
NP_143 RSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
220 230 240
>>NP_003801 (OMIM: 603598) tumor necrosis factor ligand (281 aa)
initn: 269 init1: 179 opt: 318 Z-score: 293.8 bits: 62.4 E(85289): 1.3e-09
Smith-Waterman score: 328; 25.4% identity (58.5% similar) in 284 aa overlap (42-313:10-280)
20 30 40 50 60 70
pF1KE1 LRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYFR
:. ... . .. : : .: .. . ::
NP_003 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFT
10 20 30
80 90 100 110 120
pF1KE1 AQMDP--NRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQK
.. .. :..: :. :.:. .. : . : . . . : ..: .. :.:
NP_003 NELKQMQDKYSKSGIACF-----LKEDDSYWDPN----DEESMNSPCWQVKWQLRQLVRK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 ELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLT-----INATDIPSGSHKVSL
. . ... . . : : : . . ::.: :. . :..... .:
NP_003 MILRTSEETISTVQEKQQNISPL---VRERGPQRVAAHITGTRGRSNTLSSPNSKNEKAL
100 110 120 130 140
190 200 210 220 230
pF1KE1 ----SSWYHDR-GWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLM
.:: .: : . .::. . ::.:.... ::::.:.. :: .: . . . :..
NP_003 GRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMV
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE1 VYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLL
:. : . . :. :::.. .. :: ..:. .::: ::.:.:. ...: . :.: :.
NP_003 QYIYKYT-SYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLI
210 220 230 240 250 260
300 310
pF1KE1 DPDQDATYFGAFKVRDID
: :..:..:::: :
NP_003 DMDHEASFFGAFLVG
270 280
>>NP_001191273 (OMIM: 604052) tumor necrosis factor liga (192 aa)
initn: 47 init1: 47 opt: 206 Z-score: 197.2 bits: 44.0 E(85289): 0.0003
Smith-Waterman score: 206; 27.7% identity (61.0% similar) in 159 aa overlap (163-311:35-190)
140 150 160 170 180 190
pF1KE1 HIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSS--WYHD
.: ::::. . . :. : .. . : :.
NP_001 KGRLHFSHPLSHTKHISPFVTDAPLRADGDKPRAHLTV-VRQTPTQHFKNQFPALHWEHE
10 20 30 40 50 60
200 210 220 230 240
pF1KE1 RGWAKISN-MTFSNGKLIVNQDGFYYLYANICFRHHET------SGDLATEYLQLMVYVT
: : .: :...: :.. ..: :..:... :: . .. .. .. : .:
NP_001 LGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVIT
70 80 90 100 110 120
250 260 270 280 290 300
pF1KE1 KTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLD-PD
:.. . : :. : .. :.. :. : .:..:.:. :... ..::. ::.:
NP_001 KVTDSYPEPTQLLMGTKSVCEVGSNWFQ--PIYLGAMFSLQEGDKLMVNVSDISLVDYTK
130 140 150 160 170 180
310
pF1KE1 QDATYFGAFKVRDID
.: :.::::
NP_001 EDKTFFGAFLL
190
>>NP_005109 (OMIM: 604052) tumor necrosis factor ligand (251 aa)
initn: 47 init1: 47 opt: 206 Z-score: 195.4 bits: 44.0 E(85289): 0.00038
Smith-Waterman score: 206; 27.7% identity (61.0% similar) in 159 aa overlap (163-311:94-249)
140 150 160 170 180 190
pF1KE1 HIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSS--WYHD
.: ::::. . . :. : .. . : :.
NP_005 EACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTV-VRQTPTQHFKNQFPALHWEHE
70 80 90 100 110 120
200 210 220 230 240
pF1KE1 RGWAKISN-MTFSNGKLIVNQDGFYYLYANICFRHHET------SGDLATEYLQLMVYVT
: : .: :...: :.. ..: :..:... :: . .. .. .. : .:
NP_005 LGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVIT
130 140 150 160 170 180
250 260 270 280 290 300
pF1KE1 KTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLD-PD
:.. . : :. : .. :.. :. : .:..:.:. :... ..::. ::.:
NP_005 KVTDSYPEPTQLLMGTKSVCEVGSNWFQ--PIYLGAMFSLQEGDKLMVNVSDISLVDYTK
190 200 210 220 230 240
310
pF1KE1 QDATYFGAFKVRDID
.: :.::::
NP_005 EDKTFFGAFLL
250
>>XP_016882906 (OMIM: 604520) PREDICTED: tumor necrosis (240 aa)
initn: 124 init1: 49 opt: 179 Z-score: 171.8 bits: 39.6 E(85289): 0.0079
Smith-Waterman score: 179; 26.0% identity (54.6% similar) in 196 aa overlap (122-313:52-240)
100 110 120 130 140 150
pF1KE1 RLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSW
: :: .:. .: . : . . :::
XP_016 TRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQLHWRLGEMVTRLPDGPA-GSW
30 40 50 60 70 80
160 170 180 190 200 210
pF1KE1 LDLAK-RSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQ
.: . : . :..: :::: ... .:: : : . : : . .... .: :.:..
XP_016 EQLIQERRSHEVNPAAHLTGANSSL-TGSGGPLL--WETQLGLAFLRGLSYHDGALVVTK
90 100 110 120 130
220 230 240 250 260
pF1KE1 DGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTK--YWSGNS
:.::.:... . ::. . . : . . : :. . .. ...:
XP_016 AGYYYIYSKVQLGGVGCPLGLASTITHGLY---KRTPRYPEELELLVSQQSPCGRATSSS
140 150 160 170 180 190
270 280 290 300 310
pF1KE1 EFHFYSINVGGFFKLRSGEEISIEVSNPSLLD-PDQDATYFGAFKVRDID
. . : .:: .:..::.. ..: . :. : .::::: :
XP_016 RVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
200 210 220 230 240
>>NP_003798 (OMIM: 604520) tumor necrosis factor ligand (240 aa)
initn: 124 init1: 49 opt: 179 Z-score: 171.8 bits: 39.6 E(85289): 0.0079
Smith-Waterman score: 179; 26.0% identity (54.6% similar) in 196 aa overlap (122-313:52-240)
100 110 120 130 140 150
pF1KE1 RLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSW
: :: .:. .: . : . . :::
NP_003 TRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQLHWRLGEMVTRLPDGPA-GSW
30 40 50 60 70 80
160 170 180 190 200 210
pF1KE1 LDLAK-RSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQ
.: . : . :..: :::: ... .:: : : . : : . .... .: :.:..
NP_003 EQLIQERRSHEVNPAAHLTGANSSL-TGSGGPLL--WETQLGLAFLRGLSYHDGALVVTK
90 100 110 120 130
220 230 240 250 260
pF1KE1 DGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTK--YWSGNS
:.::.:... . ::. . . : . . : :. . .. ...:
NP_003 AGYYYIYSKVQLGGVGCPLGLASTITHGLY---KRTPRYPEELELLVSQQSPCGRATSSS
140 150 160 170 180 190
270 280 290 300 310
pF1KE1 EFHFYSINVGGFFKLRSGEEISIEVSNPSLLD-PDQDATYFGAFKVRDID
. . : .:: .:..::.. ..: . :. : .::::: :
NP_003 RVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
200 210 220 230 240
317 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 17:20:59 2016 done: Tue Nov 8 17:21:00 2016
Total Scan time: 7.420 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]