Result of FASTA (ccds) for
pF1KE2062
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2062, 821 aa
1>>>pF1KE2062 821 - 821 aa - 821 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.1186+/-0.00146; mu= -2.6669+/- 0.083
mean_var=475.7568+/-108.081, 0's: 0 Z-trim(107.2): 452 B-trim: 0 in 0/52
Lambda= 0.058801
statistics sampled from 8924 (9414) to 8924 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.636), E-opt: 0.2 (0.289), width: 16
Scan time: 2.480
The best scores are: opt bits E(32554)
CCDS31298.1 FGFR2 gene_id:2263|Hs108|chr10 ( 821) 5549 487.2 4.8e-137
CCDS81515.1 FGFR2 gene_id:2263|Hs108|chr10 ( 819) 5525 485.1 2e-136
CCDS7620.2 FGFR2 gene_id:2263|Hs108|chr10 ( 822) 5372 472.2 1.6e-132
CCDS44489.1 FGFR2 gene_id:2263|Hs108|chr10 ( 769) 4981 439.0 1.5e-122
CCDS73210.1 FGFR2 gene_id:2263|Hs108|chr10 ( 732) 4722 417.0 6e-116
CCDS44485.1 FGFR2 gene_id:2263|Hs108|chr10 ( 704) 4521 399.9 7.9e-111
CCDS53584.1 FGFR2 gene_id:2263|Hs108|chr10 ( 707) 4350 385.4 1.8e-106
CCDS44488.1 FGFR2 gene_id:2263|Hs108|chr10 ( 680) 4154 368.7 1.8e-101
CCDS43732.1 FGFR1 gene_id:2260|Hs108|chr8 ( 820) 4046 359.7 1.2e-98
CCDS55223.1 FGFR1 gene_id:2260|Hs108|chr8 ( 853) 4046 359.7 1.2e-98
CCDS6107.2 FGFR1 gene_id:2260|Hs108|chr8 ( 822) 4043 359.4 1.4e-98
CCDS55222.1 FGFR1 gene_id:2260|Hs108|chr8 ( 820) 4019 357.4 5.7e-98
CCDS55221.1 FGFR1 gene_id:2260|Hs108|chr8 ( 812) 3970 353.2 1e-96
CCDS81514.1 FGFR2 gene_id:2263|Hs108|chr10 ( 593) 3858 343.5 6.1e-94
CCDS43731.1 FGFR1 gene_id:2260|Hs108|chr8 ( 731) 3757 335.1 2.6e-91
CCDS43730.1 FGFR1 gene_id:2260|Hs108|chr8 ( 733) 3754 334.8 3.1e-91
CCDS3353.1 FGFR3 gene_id:2261|Hs108|chr4 ( 806) 3401 305.0 3.4e-82
CCDS54706.1 FGFR3 gene_id:2261|Hs108|chr4 ( 808) 3285 295.1 3.1e-79
CCDS44486.1 FGFR2 gene_id:2263|Hs108|chr10 ( 709) 3156 284.1 5.7e-76
CCDS4410.1 FGFR4 gene_id:2264|Hs108|chr5 ( 802) 3035 273.9 7.6e-73
CCDS44487.1 FGFR2 gene_id:2263|Hs108|chr10 ( 705) 2690 244.6 4.5e-64
CCDS3354.1 FGFR3 gene_id:2261|Hs108|chr4 ( 694) 2174 200.8 6.7e-51
CCDS4411.1 FGFR4 gene_id:2264|Hs108|chr5 ( 762) 1808 169.8 1.6e-41
CCDS78096.1 FGFR4 gene_id:2264|Hs108|chr5 ( 734) 1662 157.4 8.3e-38
CCDS53525.1 RET gene_id:5979|Hs108|chr10 (1072) 1115 111.2 9.6e-24
CCDS7200.1 RET gene_id:5979|Hs108|chr10 (1114) 1115 111.2 9.9e-24
CCDS78389.1 TEK gene_id:7010|Hs108|chr9 ( 976) 832 87.1 1.5e-16
CCDS75825.1 TEK gene_id:7010|Hs108|chr9 (1081) 832 87.2 1.6e-16
CCDS6519.1 TEK gene_id:7010|Hs108|chr9 (1124) 832 87.2 1.7e-16
CCDS482.1 TIE1 gene_id:7075|Hs108|chr1 (1138) 830 87.1 1.9e-16
CCDS58399.1 NTRK3 gene_id:4916|Hs108|chr15 ( 817) 792 83.6 1.5e-15
CCDS10340.1 NTRK3 gene_id:4916|Hs108|chr15 ( 825) 776 82.3 3.7e-15
CCDS75874.1 MUSK gene_id:4593|Hs108|chr9 ( 783) 749 80.0 1.8e-14
CCDS48005.1 MUSK gene_id:4593|Hs108|chr9 ( 869) 749 80.0 1.9e-14
CCDS3497.1 KDR gene_id:3791|Hs108|chr4 (1356) 735 79.1 5.6e-14
CCDS5116.1 ROS1 gene_id:6098|Hs108|chr6 (2347) 737 79.6 6.9e-14
CCDS35050.1 NTRK2 gene_id:4915|Hs108|chr9 ( 822) 724 77.9 8e-14
CCDS6671.1 NTRK2 gene_id:4915|Hs108|chr9 ( 838) 720 77.5 1e-13
CCDS9330.1 FLT1 gene_id:2321|Hs108|chr13 (1338) 718 77.6 1.5e-13
CCDS30890.1 NTRK1 gene_id:4914|Hs108|chr1 ( 760) 698 75.6 3.5e-13
CCDS30891.1 NTRK1 gene_id:4914|Hs108|chr1 ( 790) 698 75.6 3.6e-13
CCDS47058.1 KIT gene_id:3815|Hs108|chr4 ( 972) 695 75.5 4.8e-13
CCDS3496.1 KIT gene_id:3815|Hs108|chr4 ( 976) 695 75.5 4.8e-13
CCDS1161.1 NTRK1 gene_id:4914|Hs108|chr1 ( 796) 685 74.5 7.7e-13
CCDS73785.1 IGF1R gene_id:3480|Hs108|chr15 (1366) 680 74.4 1.4e-12
CCDS10378.1 IGF1R gene_id:3480|Hs108|chr15 (1367) 680 74.4 1.4e-12
CCDS626.1 ROR1 gene_id:4919|Hs108|chr1 ( 937) 668 73.2 2.3e-12
CCDS6691.1 ROR2 gene_id:4920|Hs108|chr9 ( 943) 667 73.1 2.5e-12
CCDS42487.1 INSR gene_id:3643|Hs108|chr19 (1370) 666 73.2 3.3e-12
CCDS12176.1 INSR gene_id:3643|Hs108|chr19 (1382) 666 73.3 3.3e-12
>>CCDS31298.1 FGFR2 gene_id:2263|Hs108|chr10 (821 aa)
initn: 5549 init1: 5549 opt: 5549 Z-score: 2573.8 bits: 487.2 E(32554): 4.8e-137
Smith-Waterman score: 5549; 100.0% identity (100.0% similar) in 821 aa overlap (1-821:1-821)
10 20 30 40 50 60
pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS31 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
730 740 750 760 770 780
790 800 810 820
pF1KE2 PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
:::::::::::::::::::::::::::::::::::::::::
CCDS31 PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
790 800 810 820
>>CCDS81515.1 FGFR2 gene_id:2263|Hs108|chr10 (819 aa)
initn: 2935 init1: 2906 opt: 5525 Z-score: 2562.8 bits: 485.1 E(32554): 2e-136
Smith-Waterman score: 5525; 99.8% identity (99.8% similar) in 821 aa overlap (1-821:1-819)
10 20 30 40 50 60
pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
:::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 RIPLRRQV--SAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
430 440 450 460 470
490 500 510 520 530 540
pF1KE2 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE2 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE2 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE2 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE2 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS81 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
720 730 740 750 760 770
790 800 810 820
pF1KE2 PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
:::::::::::::::::::::::::::::::::::::::::
CCDS81 PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
780 790 800 810
>>CCDS7620.2 FGFR2 gene_id:2263|Hs108|chr10 (822 aa)
initn: 5263 init1: 3102 opt: 5372 Z-score: 2492.6 bits: 472.2 E(32554): 1.6e-132
Smith-Waterman score: 5372; 96.7% identity (98.2% similar) in 824 aa overlap (1-821:1-822)
10 20 30 40 50 60
pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
::::::::::::: .:.:... :. .:. ::: ::::: : ..: :: . .:::::::
CCDS76 YGPDGLPYLKVLKHSGINSSNAEVLALF--NVTEADAGEYICKVSNYIGQANQSAWLTVL
310 320 330 340 350
370 380 390 400 410
pF1KE2 P---APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 PKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE2 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE2 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE2 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE2 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY
600 610 620 630 640 650
660 670 680 690 700 710
pF1KE2 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK
660 670 680 690 700 710
720 730 740 750 760 770
pF1KE2 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE
720 730 740 750 760 770
780 790 800 810 820
pF1KE2 QYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
::::::::::::::::::::::::::::::::::::::::::::
CCDS76 QYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
780 790 800 810 820
>>CCDS44489.1 FGFR2 gene_id:2263|Hs108|chr10 (769 aa)
initn: 4872 init1: 2711 opt: 4981 Z-score: 2313.7 bits: 439.0 E(32554): 1.5e-122
Smith-Waterman score: 4981; 96.5% identity (98.1% similar) in 770 aa overlap (1-767:1-768)
10 20 30 40 50 60
pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
::::::::::::: .:.:... :. .:. ::: ::::: : ..: :: . .:::::::
CCDS44 YGPDGLPYLKVLKHSGINSSNAEVLALF--NVTEADAGEYICKVSNYIGQANQSAWLTVL
310 320 330 340 350
370 380 390 400 410
pF1KE2 P---APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 PKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE2 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE2 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE2 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE2 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY
600 610 620 630 640 650
660 670 680 690 700 710
pF1KE2 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK
660 670 680 690 700 710
720 730 740 750 760 770
pF1KE2 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE
::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI
720 730 740 750 760
780 790 800 810 820
pF1KE2 QYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
>>CCDS73210.1 FGFR2 gene_id:2263|Hs108|chr10 (732 aa)
initn: 4722 init1: 4722 opt: 4722 Z-score: 2195.2 bits: 417.0 E(32554): 6e-116
Smith-Waterman score: 4765; 89.2% identity (89.2% similar) in 821 aa overlap (1-821:1-732)
10 20 30 40 50 60
pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
::::::::::::::::::::::::::::::::::::
CCDS73 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE------------------------
10 20 30
70 80 90 100 110 120
pF1KE2 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
CCDS73 ------------------------------------------------------------
130 140 150 160 170 180
pF1KE2 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS73 -----DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE2 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS73 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE2 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS73 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE2 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS73 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE2 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS73 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE2 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS73 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
340 350 360 370 380 390
490 500 510 520 530 540
pF1KE2 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS73 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
400 410 420 430 440 450
550 560 570 580 590 600
pF1KE2 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS73 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
460 470 480 490 500 510
610 620 630 640 650 660
pF1KE2 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS73 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
520 530 540 550 560 570
670 680 690 700 710 720
pF1KE2 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS73 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
580 590 600 610 620 630
730 740 750 760 770 780
pF1KE2 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS73 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
640 650 660 670 680 690
790 800 810 820
pF1KE2 PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
:::::::::::::::::::::::::::::::::::::::::
CCDS73 PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
700 710 720 730
>>CCDS44485.1 FGFR2 gene_id:2263|Hs108|chr10 (704 aa)
initn: 2878 init1: 2655 opt: 4521 Z-score: 2103.2 bits: 399.9 E(32554): 7.9e-111
Smith-Waterman score: 4521; 99.7% identity (99.7% similar) in 669 aa overlap (153-821:38-704)
130 140 150 160 170 180
pF1KE2 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG
::::::::::::::::::::::::::::::
CCDS44 ICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAG
10 20 30 40 50 60
190 200 210 220 230 240
pF1KE2 GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH
70 80 90 100 110 120
250 260 270 280 290 300
pF1KE2 TYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 TYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYG
130 140 150 160 170 180
310 320 330 340 350 360
pF1KE2 PDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 PDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPA
190 200 210 220 230 240
370 380 390 400 410 420
pF1KE2 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI
250 260 270 280 290 300
430 440 450 460 470 480
pF1KE2 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT
:::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 PLRRQV--SAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT
310 320 330 340 350 360
490 500 510 520 530 540
pF1KE2 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
370 380 390 400 410 420
550 560 570 580 590 600
pF1KE2 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD
430 440 450 460 470 480
610 620 630 640 650 660
pF1KE2 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN
490 500 510 520 530 540
670 680 690 700 710 720
pF1KE2 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM
550 560 570 580 590 600
730 740 750 760 770 780
pF1KE2 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS
610 620 630 640 650 660
790 800 810 820
pF1KE2 YPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
:::::::::::::::::::::::::::::::::::::::
CCDS44 YPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
670 680 690 700
>>CCDS53584.1 FGFR2 gene_id:2263|Hs108|chr10 (707 aa)
initn: 4337 init1: 4337 opt: 4350 Z-score: 2024.8 bits: 385.4 E(32554): 1.8e-106
Smith-Waterman score: 4393; 86.3% identity (87.2% similar) in 790 aa overlap (1-790:1-701)
10 20 30 40 50 60
pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
::::::::::::::::::::::::::::::::::::
CCDS53 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE------------------------
10 20 30
70 80 90 100 110 120
pF1KE2 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
CCDS53 ------------------------------------------------------------
130 140 150 160 170 180
pF1KE2 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 -----DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE2 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE2 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE2 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE2 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE2 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
340 350 360 370 380 390
490 500 510 520 530 540
pF1KE2 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
400 410 420 430 440 450
550 560 570 580 590 600
pF1KE2 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
460 470 480 490 500 510
610 620 630 640 650 660
pF1KE2 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
520 530 540 550 560 570
670 680 690 700 710 720
pF1KE2 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
580 590 600 610 620 630
730 740 750 760 770 780
pF1KE2 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
:::::::::::::::::::::::::::::::::::::::::::::::: .: .. ..
CCDS53 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHK
640 650 660 670 680 690
790 800 810 820
pF1KE2 PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
: .. :
CCDS53 PPCNPSHLPCVLAVDQ
700
>>CCDS44488.1 FGFR2 gene_id:2263|Hs108|chr10 (680 aa)
initn: 4045 init1: 2711 opt: 4154 Z-score: 1935.1 bits: 368.7 E(32554): 1.8e-101
Smith-Waterman score: 4197; 84.9% identity (86.5% similar) in 770 aa overlap (1-767:1-679)
10 20 30 40 50 60
pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
::::::::::::::::::::::::::::::::::::
CCDS44 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE------------------------
10 20 30
70 80 90 100 110 120
pF1KE2 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
CCDS44 ------------------------------------------------------------
130 140 150 160 170 180
pF1KE2 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 -----DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE2 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE2 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE2 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
::::::::::::: .:.:... :. .:. ::: ::::: : ..: :: . .:::::::
CCDS44 YGPDGLPYLKVLKHSGINSSNAEVLALF--NVTEADAGEYICKVSNYIGQANQSAWLTVL
220 230 240 250 260
370 380 390 400 410
pF1KE2 P---APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 PKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK
270 280 290 300 310 320
420 430 440 450 460 470
pF1KE2 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP
330 340 350 360 370 380
480 490 500 510 520 530
pF1KE2 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM
390 400 410 420 430 440
540 550 560 570 580 590
pF1KE2 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ
450 460 470 480 490 500
600 610 620 630 640 650
pF1KE2 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY
510 520 530 540 550 560
660 670 680 690 700 710
pF1KE2 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK
570 580 590 600 610 620
720 730 740 750 760 770
pF1KE2 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE
::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS44 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI
630 640 650 660 670 680
780 790 800 810 820
pF1KE2 QYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
>>CCDS43732.1 FGFR1 gene_id:2260|Hs108|chr8 (820 aa)
initn: 3880 init1: 2074 opt: 4046 Z-score: 1884.7 bits: 359.7 E(32554): 1.2e-98
Smith-Waterman score: 4046; 71.8% identity (88.6% similar) in 827 aa overlap (1-820:1-818)
10 20 30 40 50 60
pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
: :: .. .:.. ::: :::: .: :.. .: :.. : ... ::. :..
CCDS43 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL
10 20 30 40 50
70 80 90 100 110
pF1KE2 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY
:: :.: . :.: .:::.:. .::: . :: .... ..: :::::::..: :.: :
CCDS43 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVK
: :::.::. :..:.:: : . . .:..:.: :::::. :::::.:::::::.:::
CCDS43 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 FRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
:.::..:.: ::.:::::::::: .::::::::: ::.::.::::::::::::.::::
CCDS43 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 YGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEK
::::::::.:::::::::::::::::::: ....:..:::.:::::: ::::::.::.:
CCDS43 YGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 NGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAW
:::: :::.:::...::.:::::::::.:::..:::.::::::::::::::::.: ::::
CCDS43 NGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAW
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE2 LTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVH
:::: : .. . .:: :::: ::: :.:::.::: .::. .::. ::: :: :: :::
CCDS43 LTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVH
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE2 KLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEF
::.: :::::::::::.::.::::.. ::: .::::.. ::::::::::::::::.::.
CCDS43 KLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWEL
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE2 PRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEME
:::.:.::::::::::::::.:::.:.:::::.... :::::::.::::::::::.::::
CCDS43 PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEME
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE2 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEE
::::::::::::::::::::::::::::::::::::::::.::::::.:: :. .. :::
CCDS43 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEE
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE2 QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDY
:.. ::::::.::.:::::::::.::::::::::::::::.::::::::::::::..:::
CCDS43 QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDY
600 610 620 630 640 650
660 670 680 690 700 710
pF1KE2 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL
::::::::::::::::::::::.:::::::::::::.:::::::::::::.:::::::::
CCDS43 YKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL
660 670 680 690 700 710
720 730 740 750 760 770
pF1KE2 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPL
:::::::::.::::::::::::::::::::::::::::::::::..::.:.::::::.::
CCDS43 KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPL
720 730 740 750 760 770
780 790 800 810 820
pF1KE2 EQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVKT
.:::::.:::::: ::::.::::: .:.: :::::..: ::..:
CCDS43 DQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
780 790 800 810 820
>>CCDS55223.1 FGFR1 gene_id:2260|Hs108|chr8 (853 aa)
initn: 3880 init1: 2074 opt: 4046 Z-score: 1884.5 bits: 359.7 E(32554): 1.2e-98
Smith-Waterman score: 4046; 71.8% identity (88.6% similar) in 827 aa overlap (1-820:34-851)
10 20 30
pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVED
: :: .. .:.. ::: :::: .: :.
CCDS55 RVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQ
10 20 30 40 50 60
40 50 60 70 80
pF1KE2 TTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKD-AAVISWTKDGVHLGPNNRTVLIG
. .: :.. : ... ::. :..:: :.: . :.: .:::.:. .::: . :
CCDS55 A--QPWGAPVEV-----ESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITG
70 80 90 100 110
90 100 110 120 130 140
pF1KE2 EYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSN
: .... ..: :::::::..: :.: :: :::.::. :..:.:: : . . .:..:
CCDS55 EEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
120 130 140 150 160 170
150 160 170 180 190 200
pF1KE2 NKR---APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGG
.: :::::. :::::.:::::::.::::.::..:.: ::.:::::::::: .:::::
CCDS55 TKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGG
180 190 200 210 220 230
210 220 230 240 250 260
pF1KE2 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANA
:::: ::.::.::::::::::::.::::::::::::.::::::::::::::::::::
CCDS55 YKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANK
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE2 STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEV
....:..:::.:::::: ::::::.::.: :::: :::.:::...::.:::::::::.::
CCDS55 TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEV
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE2 LYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVF
:..:::.::::::::::::::::.: :::::::: : .. . .:: :::: ::: :.:
CCDS55 LHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAF
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE2 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR
::.::: .::. .::. ::: :: :: :::::.: :::::::::::.::.::::.. :::
CCDS55 LISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR
420 430 440 450 460 470
450 460 470 480 490 500
pF1KE2 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD
.::::.. ::::::::::::::::.::.:::.:.::::::::::::::.:::.:.:::
CCDS55 -PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD
480 490 500 510 520 530
510 520 530 540 550 560
pF1KE2 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY
::.... :::::::.::::::::::.::::::::::::::::::::::::::::::::::
CCDS55 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY
540 550 560 570 580 590
570 580 590 600 610 620
pF1KE2 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD
::::::::::.::::::.:: :. .. ::::.. ::::::.::.:::::::::.::::::
CCDS55 ASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRD
600 610 620 630 640 650
630 640 650 660 670 680
pF1KE2 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV
::::::::::.::::::::::::::..:::::::::::::::::::::::::.:::::::
CCDS55 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV
660 670 680 690 700 710
690 700 710 720 730 740
pF1KE2 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ
::::::.:::::::::::::.::::::::::::::::::.::::::::::::::::::::
CCDS55 WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQ
720 730 740 750 760 770
750 760 770 780 790 800
pF1KE2 RPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPY
::::::::::::::..::.:.::::::.::.:::::.:::::: ::::.::::: .:.:
CCDS55 RPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPE
780 790 800 810 820 830
810 820
pF1KE2 EPCLPQYPH--INGSVKT
:::::..: ::..:
CCDS55 EPCLPRHPAQLANGGLKRR
840 850
821 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 15:20:43 2016 done: Sun Nov 6 15:20:43 2016
Total Scan time: 2.480 Total Display time: 0.200
Function used was FASTA [36.3.4 Apr, 2011]