FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2078, 748 aa 1>>>pF1KE2078 748 - 748 aa - 748 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.5860+/-0.000398; mu= 10.1592+/- 0.025 mean_var=157.2415+/-30.394, 0's: 0 Z-trim(117.8): 162 B-trim: 43 in 1/53 Lambda= 0.102280 statistics sampled from 29905 (30084) to 29905 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.696), E-opt: 0.2 (0.353), width: 16 Scan time: 10.670 The best scores are: opt bits E(85289) NP_001101 (OMIM: 602192,615537,615590) disintegrin ( 748) 5277 791.2 0 XP_016877350 (OMIM: 602192,615537,615590) PREDICTE ( 674) 4770 716.3 9.8e-206 NP_001307499 (OMIM: 602192,615537,615590) disinteg ( 717) 3419 517.0 1.1e-145 NP_003174 (OMIM: 603639,614328) disintegrin and me ( 824) 727 119.8 4.4e-26 XP_011508677 (OMIM: 603639,614328) PREDICTED: disi ( 793) 726 119.7 4.8e-26 XP_016860274 (OMIM: 603639,614328) PREDICTED: disi ( 525) 685 113.5 2.3e-24 XP_011508679 (OMIM: 603639,614328) PREDICTED: disi ( 525) 685 113.5 2.3e-24 XP_016860275 (OMIM: 603639,614328) PREDICTED: disi ( 525) 685 113.5 2.3e-24 XP_011508678 (OMIM: 603639,614328) PREDICTED: disi ( 604) 685 113.5 2.6e-24 NP_001248395 (OMIM: 605548) disintegrin and metall ( 633) 397 71.1 1.7e-11 NP_997074 (OMIM: 605548) disintegrin and metallopr ( 772) 397 71.1 1.9e-11 NP_001248394 (OMIM: 605548) disintegrin and metall ( 796) 397 71.1 2e-11 NP_003806 (OMIM: 605548) disintegrin and metallopr ( 814) 397 71.1 2e-11 NP_001248393 (OMIM: 605548) disintegrin and metall ( 824) 397 71.1 2e-11 NP_997078 (OMIM: 605548) disintegrin and metallopr ( 838) 397 71.1 2.1e-11 NP_997077 (OMIM: 605548) disintegrin and metallopr ( 839) 397 71.1 2.1e-11 NP_997079 (OMIM: 605548) disintegrin and metallopr ( 862) 397 71.2 2.1e-11 NP_997080 (OMIM: 605548) disintegrin and metallopr ( 863) 397 71.2 2.1e-11 XP_011527672 (OMIM: 607114) PREDICTED: disintegrin ( 635) 374 67.7 1.7e-10 XP_011527675 (OMIM: 607114) PREDICTED: disintegrin ( 492) 372 67.3 1.8e-10 NP_694882 (OMIM: 607114) disintegrin and metallopr ( 787) 373 67.6 2.3e-10 XP_011527670 (OMIM: 607114) PREDICTED: disintegrin ( 800) 373 67.6 2.3e-10 XP_011527669 (OMIM: 607114) PREDICTED: disintegrin ( 812) 373 67.6 2.3e-10 NP_001269376 (OMIM: 607114) disintegrin and metall ( 812) 373 67.6 2.3e-10 NP_079496 (OMIM: 607114) disintegrin and metallopr ( 813) 373 67.6 2.3e-10 XP_011527668 (OMIM: 607114) PREDICTED: disintegrin ( 825) 373 67.6 2.4e-10 XP_006723702 (OMIM: 607114) PREDICTED: disintegrin ( 825) 373 67.6 2.4e-10 XP_005260900 (OMIM: 607114) PREDICTED: disintegrin ( 826) 373 67.6 2.4e-10 XP_006723703 (OMIM: 607114) PREDICTED: disintegrin ( 823) 372 67.4 2.6e-10 XP_011542984 (OMIM: 602713,612775) PREDICTED: disi ( 801) 364 66.3 5.8e-10 NP_003807 (OMIM: 602713,612775) disintegrin and me ( 819) 364 66.3 5.9e-10 XP_016869431 (OMIM: 602713,612775) PREDICTED: disi ( 821) 364 66.3 5.9e-10 XP_016865498 (OMIM: 603640) PREDICTED: disintegrin ( 651) 338 62.4 7e-09 XP_011532984 (OMIM: 603640) PREDICTED: disintegrin ( 651) 338 62.4 7e-09 NP_001265043 (OMIM: 601533) disintegrin and metall ( 672) 336 62.1 8.9e-09 NP_150377 (OMIM: 603640) disintegrin and metallopr ( 918) 338 62.5 9.2e-09 XP_005266060 (OMIM: 603640) PREDICTED: disintegrin ( 955) 338 62.5 9.5e-09 XP_011542782 (OMIM: 601533) PREDICTED: disintegrin ( 579) 329 61.0 1.6e-08 XP_005273525 (OMIM: 601533) PREDICTED: disintegrin ( 705) 329 61.1 1.9e-08 XP_011542673 (OMIM: 606188) PREDICTED: disintegrin ( 522) 319 59.5 4.1e-08 NP_068547 (OMIM: 606188) disintegrin and metallopr ( 540) 319 59.5 4.3e-08 XP_011542672 (OMIM: 606188) PREDICTED: disintegrin ( 542) 319 59.5 4.3e-08 NP_001275904 (OMIM: 602714) disintegrin and metall ( 735) 321 59.9 4.4e-08 NP_001275903 (OMIM: 602714) disintegrin and metall ( 737) 321 59.9 4.4e-08 NP_067673 (OMIM: 602714) disintegrin and metallopr ( 738) 321 59.9 4.4e-08 XP_016872194 (OMIM: 602714) PREDICTED: disintegrin ( 753) 321 59.9 4.5e-08 XP_005273439 (OMIM: 606188) PREDICTED: disintegrin ( 621) 319 59.5 4.7e-08 XP_011542671 (OMIM: 606188) PREDICTED: disintegrin ( 673) 319 59.6 5.1e-08 NP_001275902 (OMIM: 602714) disintegrin and metall ( 906) 321 60.0 5.2e-08 NP_003465 (OMIM: 602714) disintegrin and metallopr ( 909) 321 60.0 5.2e-08 >>NP_001101 (OMIM: 602192,615537,615590) disintegrin and (748 aa) initn: 5277 init1: 5277 opt: 5277 Z-score: 4218.3 bits: 791.2 E(85289): 0 Smith-Waterman score: 5277; 100.0% identity (100.0% similar) in 748 aa overlap (1-748:1-748) 10 20 30 40 50 60 pF1KE2 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL 670 680 690 700 710 720 730 740 pF1KE2 KRRRPPQPIQQPQRQRPRESYQMGHMRR :::::::::::::::::::::::::::: NP_001 KRRRPPQPIQQPQRQRPRESYQMGHMRR 730 740 >>XP_016877350 (OMIM: 602192,615537,615590) PREDICTED: d (674 aa) initn: 4770 init1: 4770 opt: 4770 Z-score: 3814.6 bits: 716.3 E(85289): 9.8e-206 Smith-Waterman score: 4770; 100.0% identity (100.0% similar) in 674 aa overlap (75-748:1-674) 50 60 70 80 90 100 pF1KE2 KHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYT :::::::::::::::::::::::::::::: XP_016 MKRDTSLFSDEFKVETSNKVLDYDTSHIYT 10 20 30 110 120 130 140 150 160 pF1KE2 GHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYP 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE2 HKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQL 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE2 YIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEK 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE2 DPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGIC 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE2 EKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGES 280 290 300 310 320 330 410 420 430 440 450 460 pF1KE2 KNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGM 340 350 360 370 380 390 470 480 490 500 510 520 pF1KE2 VEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKC 400 410 420 430 440 450 530 540 550 560 570 580 pF1KE2 RDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCAS 460 470 480 490 500 510 590 600 610 620 630 640 pF1KE2 SDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMR 520 530 540 550 560 570 650 660 670 680 690 700 pF1KE2 CRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTP 580 590 600 610 620 630 710 720 730 740 pF1KE2 SSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR :::::::::::::::::::::::::::::::::::::::::::: XP_016 SSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR 640 650 660 670 >>NP_001307499 (OMIM: 602192,615537,615590) disintegrin (717 aa) initn: 3419 init1: 3419 opt: 3419 Z-score: 2736.8 bits: 517.0 E(85289): 1.1e-145 Smith-Waterman score: 5013; 95.9% identity (95.9% similar) in 748 aa overlap (1-748:1-717) 10 20 30 40 50 60 pF1KE2 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF :::::: ::::::::::::::::::::::: NP_001 AVIAQI-------------------------------NTTADEKDPTNPFRFPNIGVEKF 250 260 310 320 330 340 350 360 pF1KE2 LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE2 GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE2 ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK 390 400 410 420 430 440 490 500 510 520 530 540 pF1KE2 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT 450 460 470 480 490 500 550 560 570 580 590 600 pF1KE2 ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK 510 520 530 540 550 560 610 620 630 640 650 660 pF1KE2 KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA 570 580 590 600 610 620 670 680 690 700 710 720 pF1KE2 IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL 630 640 650 660 670 680 730 740 pF1KE2 KRRRPPQPIQQPQRQRPRESYQMGHMRR :::::::::::::::::::::::::::: NP_001 KRRRPPQPIQQPQRQRPRESYQMGHMRR 690 700 710 >>NP_003174 (OMIM: 603639,614328) disintegrin and metall (824 aa) initn: 739 init1: 240 opt: 727 Z-score: 589.2 bits: 119.8 E(85289): 4.4e-26 Smith-Waterman score: 979; 28.0% identity (56.2% similar) in 778 aa overlap (16-742:25-757) 10 20 30 40 50 pF1KE2 MVLLRVLILLLSWAAGMGG-QYGNPLNKYIRHYEGLSYNVDSLHQKHQRAK :.: : . :.. . :. :: . . :. ..: NP_003 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDL 10 20 30 40 50 60 60 70 80 90 100 pF1KE2 RAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKV---ETSNKVLDYDTS--HIYTG .. .: . .: : : :::.: . .: ::..::: . .:. .: .. ..:: NP_003 QTSTHVETLL--TFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNES-EYTVKWQDFFTG 70 80 90 100 110 110 120 130 140 150 160 pF1KE2 HIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPH :. :: : . . : :.: :. . .:: :...: : . ..:. .::. NP_003 HVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVND-TKDKRMLVYKSEDIKNVS 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 KYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLY . :. . .. . .. : . : :: . . .... . ::::.: NP_003 RLQSPKVCG----YLKVDNEELLPKGLVDREPPEELV----HRVKRRADPDPMKNTCKLL 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 IQTDHLFFKYYGTRE--AVIAQISSHVKAIDTIYQTT--DFSGIRNISFMVKRIRINTTA . .:: :..:.: : .. . . .: ::..: : .:... ......::: . NP_003 VVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSP 230 240 250 260 270 280 290 300 310 320 pF1KE2 DEKDPTNPFR-----FPN-----IGVEKFLE---LNSEQNHDDYCLAYVFTDRDFDDGVL .: : . .:: :. .:: .. .. . :::..:: .::: :.: NP_003 QEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTL 290 300 310 320 330 340 330 340 350 360 370 380 pF1KE2 GLAWVGAPSGSS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHEVG :::.::.: ..: ::.: :. :::. ::.:. ...:::. . : . .. .::.: NP_003 GLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELG 350 360 370 380 390 400 390 400 410 420 430 440 pF1KE2 HNFGSPHDSG--TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVL ::::. :: .::.:.:.. .:.:.:: :.:::. ::. :: :: ..: ... NP_003 HNFGAEHDPDGLAECAPNEDQ------GGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTI 410 420 430 440 450 460 450 460 470 480 490 500 pF1KE2 EKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCS :.: ..:: : .. .:::. :..::::: : .: :: . : :: : ::: NP_003 ESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQCS 470 480 490 500 510 510 520 530 540 550 560 pF1KE2 PSQGPCCTAQCAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVC ..::: .: :.. ..::.. .. : . :.: .. :: . : : . : NP_003 DRNSPCCK-NCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK-C 520 530 540 550 560 570 570 580 590 600 610 620 pF1KE2 INGQCAGSICEK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSG .:.: .::. :: :.: .:.. :.::: . .. . :. ... . : NP_003 KDGKCI-PFCEREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF-- 580 590 600 610 620 630 640 650 660 670 pF1KE2 RTITLQPGSPCNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEWIV :. :.::. :.::. .: :. :. . .:. :. : .::. .. NP_003 ----LRKGKPCT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVL 630 640 650 660 670 680 690 700 710 720 pF1KE2 AH---WW---AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL . .: ..:. . .: .. . ... : :.. .. : : : : NP_003 VFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQTP 680 690 700 710 720 730 730 740 pF1KE2 KRRRPPQPIQQPQRQRPRESYQMGHMRR : .: :. :. ..: NP_003 GRLQPA-PVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDL 740 750 760 770 780 790 >>XP_011508677 (OMIM: 603639,614328) PREDICTED: disinteg (793 aa) initn: 739 init1: 240 opt: 726 Z-score: 588.6 bits: 119.7 E(85289): 4.8e-26 Smith-Waterman score: 976; 28.0% identity (56.1% similar) in 768 aa overlap (25-742:4-726) 10 20 30 40 50 60 pF1KE2 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL :.. . :. :: . . :. ..: .. .: . .: XP_011 MKKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLL 10 20 30 70 80 90 100 110 pF1KE2 RLDFHAHGRHFNLRMKRDTSLFSDEFKV---ETSNKVLDYDTS--HIYTGHIYGEEGSFS : : :::.: . .: ::..::: . .:. .: .. ..:::. :: : XP_011 --TFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNES-EYTVKWQDFFTGHVVGEPDSRV 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE2 HGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCAD . . : :.: :. . .:: :...: : . ..:. .::. . :. XP_011 LAHIRDDDVIIRINTDGAEYNIEPLWRFVND-TKDKRMLVYKSEDIKNVSRLQSPKVCG- 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE2 HSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKY . .. . .. : . : :: . .... . ::::.: . .:: :..: XP_011 ---YLKVDNEELLPKGLVDREPPEELVHR----VKRRADPDPMKNTCKLLVVADHRFYRY 160 170 180 190 200 240 250 260 270 280 290 pF1KE2 YGTRE--AVIAQISSHVKAIDTIYQTT--DFSGIRNISFMVKRIRINTTADEKDPTNPFR .: : .. . . .: ::..: : .:... ......::: . .: : . XP_011 MGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHY 210 220 230 240 250 260 300 310 320 330 pF1KE2 -----FPN-----IGVEKFLE---LNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSG .:: :. .:: .. .. . :::..:: .::: :.::::.::.: . XP_011 NMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRA 270 280 290 300 310 320 340 350 360 370 380 390 pF1KE2 SS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSG .: ::.: :. :::. ::.:. ...:::. . : . .. .::.:::::. :: XP_011 NSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPD 330 340 350 360 370 380 400 410 420 430 440 450 pF1KE2 --TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVE .::.:.:... :.:.:: :.:::. ::. :: :: ..: ...:.: ..:: : XP_011 GLAECAPNEDQG------GKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQE 390 400 410 420 430 440 460 470 480 490 500 510 pF1KE2 SGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQ .. .:::. :..::::: : .: :: . : :: : ::: ..::: . XP_011 RSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQCSDRNSPCCK-N 450 460 470 480 490 520 530 540 550 560 570 pF1KE2 CAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSIC : :.. ..::.. .. : . :.: .. :: . : : . : .:.: .: XP_011 CQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK-CKDGKCI-PFC 500 510 520 530 540 550 580 590 600 610 620 630 pF1KE2 EK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSP :. :: :.: .:.. :.::: . .. . :. ... . : :. :.: XP_011 EREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF------LRKGKP 560 570 580 590 640 650 660 670 pF1KE2 CNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEWIVAH---WW--- :. :.::. .: :. :. . .:. :. : .::. ... .: XP_011 CT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPF 600 610 620 630 640 650 680 690 700 710 720 730 pF1KE2 AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQ ..:. . .: .. . ... : :.. .. : : : : : .: :. XP_011 SILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQTPGRLQPA-PVI 660 670 680 690 700 710 740 pF1KE2 QPQRQRPRESYQMGHMRR :. ..: XP_011 PSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEK 720 730 740 750 760 770 >>XP_016860274 (OMIM: 603639,614328) PREDICTED: disinteg (525 aa) initn: 545 init1: 240 opt: 685 Z-score: 558.4 bits: 113.5 E(85289): 2.3e-24 Smith-Waterman score: 743; 30.6% identity (58.0% similar) in 474 aa overlap (297-742:19-458) 270 280 290 300 310 320 pF1KE2 NISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDG .:.: .. .. . :::..:: .::: : XP_016 MAKSYPNEEKDAWDVKMLLEQF-SFDIAEEASKVCLAHLFTYQDFDMG 10 20 30 40 330 340 350 360 370 380 pF1KE2 VLGLAWVGAPSGSS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHE .::::.::.: ..: ::.: :. :::. ::.:. ...:::. . : . .. .:: XP_016 TLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHE 50 60 70 80 90 100 390 400 410 420 430 440 pF1KE2 VGHNFGSPHDSG--TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQ .:::::. :: .::.:.:... :.:.:: :.:::. ::. :: :: ..: . XP_016 LGHNFGAEHDPDGLAECAPNEDQG------GKYVMYPIAVSGDHENNKMFSNCSKQSIYK 110 120 130 140 150 160 450 460 470 480 490 500 pF1KE2 VLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQ ..:.: ..:: : .. .:::. :..::::: : .: :: . : :: : : XP_016 TIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQ 170 180 190 200 210 510 520 530 540 550 560 pF1KE2 CSPSQGPCCTAQCAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQ :: ..::: .: :.. ..::.. .. : . :.: .. :: . : : . XP_016 CSDRNSPCCK-NCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK 220 230 240 250 260 270 570 580 590 600 610 pF1KE2 VCINGQCAGSICEK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHF : .:.: .::. :: :.: .:.. :.::: . .. . :. ... . : XP_016 -CKDGKCI-PFCEREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF 280 290 300 310 320 620 630 640 650 660 670 pF1KE2 SGRTITLQPGSPCNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEW :. :.::. :.::. .: :. :. . .:. :. : .::. XP_016 ------LRKGKPCT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGS 330 340 350 360 370 680 690 700 710 pF1KE2 IVAH---WW---AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPG ... .: ..:. . .: .. . ... : :.. .. : : : XP_016 VLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQ 380 390 400 410 420 430 720 730 740 pF1KE2 TLKRRRPPQPIQQPQRQRPRESYQMGHMRR : : : :. :. ..: XP_016 T-PGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFE 440 450 460 470 480 490 >>XP_011508679 (OMIM: 603639,614328) PREDICTED: disinteg (525 aa) initn: 545 init1: 240 opt: 685 Z-score: 558.4 bits: 113.5 E(85289): 2.3e-24 Smith-Waterman score: 743; 30.6% identity (58.0% similar) in 474 aa overlap (297-742:19-458) 270 280 290 300 310 320 pF1KE2 NISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDG .:.: .. .. . :::..:: .::: : XP_011 MAKSYPNEEKDAWDVKMLLEQF-SFDIAEEASKVCLAHLFTYQDFDMG 10 20 30 40 330 340 350 360 370 380 pF1KE2 VLGLAWVGAPSGSS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHE .::::.::.: ..: ::.: :. :::. ::.:. ...:::. . : . .. .:: XP_011 TLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHE 50 60 70 80 90 100 390 400 410 420 430 440 pF1KE2 VGHNFGSPHDSG--TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQ .:::::. :: .::.:.:... :.:.:: :.:::. ::. :: :: ..: . XP_011 LGHNFGAEHDPDGLAECAPNEDQG------GKYVMYPIAVSGDHENNKMFSNCSKQSIYK 110 120 130 140 150 160 450 460 470 480 490 500 pF1KE2 VLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQ ..:.: ..:: : .. .:::. :..::::: : .: :: . : :: : : XP_011 TIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQ 170 180 190 200 210 510 520 530 540 550 560 pF1KE2 CSPSQGPCCTAQCAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQ :: ..::: .: :.. ..::.. .. : . :.: .. :: . : : . XP_011 CSDRNSPCCK-NCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK 220 230 240 250 260 270 570 580 590 600 610 pF1KE2 VCINGQCAGSICEK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHF : .:.: .::. :: :.: .:.. :.::: . .. . :. ... . : XP_011 -CKDGKCI-PFCEREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF 280 290 300 310 320 620 630 640 650 660 670 pF1KE2 SGRTITLQPGSPCNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEW :. :.::. :.::. .: :. :. . .:. :. : .::. XP_011 ------LRKGKPCT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGS 330 340 350 360 370 680 690 700 710 pF1KE2 IVAH---WW---AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPG ... .: ..:. . .: .. . ... : :.. .. : : : XP_011 VLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQ 380 390 400 410 420 430 720 730 740 pF1KE2 TLKRRRPPQPIQQPQRQRPRESYQMGHMRR : : : :. :. ..: XP_011 T-PGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFE 440 450 460 470 480 490 >>XP_016860275 (OMIM: 603639,614328) PREDICTED: disinteg (525 aa) initn: 545 init1: 240 opt: 685 Z-score: 558.4 bits: 113.5 E(85289): 2.3e-24 Smith-Waterman score: 743; 30.6% identity (58.0% similar) in 474 aa overlap (297-742:19-458) 270 280 290 300 310 320 pF1KE2 NISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDG .:.: .. .. . :::..:: .::: : XP_016 MAKSYPNEEKDAWDVKMLLEQF-SFDIAEEASKVCLAHLFTYQDFDMG 10 20 30 40 330 340 350 360 370 380 pF1KE2 VLGLAWVGAPSGSS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHE .::::.::.: ..: ::.: :. :::. ::.:. ...:::. . : . .. .:: XP_016 TLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHE 50 60 70 80 90 100 390 400 410 420 430 440 pF1KE2 VGHNFGSPHDSG--TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQ .:::::. :: .::.:.:... :.:.:: :.:::. ::. :: :: ..: . XP_016 LGHNFGAEHDPDGLAECAPNEDQG------GKYVMYPIAVSGDHENNKMFSNCSKQSIYK 110 120 130 140 150 160 450 460 470 480 490 500 pF1KE2 VLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQ ..:.: ..:: : .. .:::. :..::::: : .: :: . : :: : : XP_016 TIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQ 170 180 190 200 210 510 520 530 540 550 560 pF1KE2 CSPSQGPCCTAQCAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQ :: ..::: .: :.. ..::.. .. : . :.: .. :: . : : . XP_016 CSDRNSPCCK-NCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK 220 230 240 250 260 270 570 580 590 600 610 pF1KE2 VCINGQCAGSICEK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHF : .:.: .::. :: :.: .:.. :.::: . .. . :. ... . : XP_016 -CKDGKCI-PFCEREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF 280 290 300 310 320 620 630 640 650 660 670 pF1KE2 SGRTITLQPGSPCNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEW :. :.::. :.::. .: :. :. . .:. :. : .::. XP_016 ------LRKGKPCT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGS 330 340 350 360 370 680 690 700 710 pF1KE2 IVAH---WW---AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPG ... .: ..:. . .: .. . ... : :.. .. : : : XP_016 VLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQ 380 390 400 410 420 430 720 730 740 pF1KE2 TLKRRRPPQPIQQPQRQRPRESYQMGHMRR : : : :. :. ..: XP_016 T-PGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFE 440 450 460 470 480 490 >>XP_011508678 (OMIM: 603639,614328) PREDICTED: disinteg (604 aa) initn: 617 init1: 240 opt: 685 Z-score: 557.6 bits: 113.5 E(85289): 2.6e-24 Smith-Waterman score: 838; 29.9% identity (57.6% similar) in 569 aa overlap (219-742:2-537) 190 200 210 220 230 240 pF1KE2 GVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE--AVIAQI ::::.: . .:: :..:.: : .. . XP_011 MKNTCKLLVVADHRFYRYMGRGEESTTTNYL 10 20 30 250 260 270 280 290 pF1KE2 SSHVKAIDTIYQTT--DFSGIRNISFMVKRIRINTTADEKDPTNPFR-----FPN----- . .: ::..: : .:... ......::: . .: : . .:: XP_011 IELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDA 40 50 60 70 80 90 300 310 320 330 340 350 pF1KE2 IGVEKFLE---LNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSS-GGICEKSKLY :. .:: .. .. . :::..:: .::: :.::::.::.: ..: ::.: :. XP_011 WDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYS 100 110 120 130 140 150 360 370 380 390 400 pF1KE2 SDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSG--TECTPGESKNL :::. ::.:. ...:::. . : . .. .::.:::::. :: .::.:.:... XP_011 PVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQG- 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE2 GQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQ :.:.:: :.:::. ::. :: :: ..: ...:.: ..:: : .. .:::. :.. XP_011 -----GKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDE 220 230 240 250 260 470 480 490 500 510 520 pF1KE2 GEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRD- ::::: : .: :: . : :: : ::: ..::: .: :.. ..::.. XP_011 GEECDPGIMYLNNDTCC-------NSDCTLKEGVQCSDRNSPCCK-NCQFETAQKKCQEA 270 280 290 300 310 530 540 550 560 570 580 pF1KE2 -DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEK-YGLEECTCAS .. : . :.: .. :: . : : . : .:.: .::. :: :.: XP_011 INATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK-CKDGKCI-PFCEREQQLESCACNE 320 330 340 350 360 370 590 600 610 620 630 640 pF1KE2 SDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMR .:.. :.::: . .. . :. ... . : :. :.::. :.::. . XP_011 TDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF------LRKGKPCT--VGFCDMNGK 380 390 400 410 420 650 660 670 680 pF1KE2 C--RLVDAD----GPLARLKKAIFSPELYENIAEWIVAH---WW---AVLLMGI------ : :. :. . .:. :. : .::. ... .: ..:. . XP_011 CEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDK 430 440 450 460 470 480 690 700 710 720 730 740 pF1KE2 ---ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQM .: .. . ... : :.. .. : : : : : .: :. :. ..: XP_011 QYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQTPGRLQPA-PVIPSAPAAPKLDHQR 490 500 510 520 530 pF1KE2 GHMRR XP_011 MDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVD 540 550 560 570 580 590 >>NP_001248395 (OMIM: 605548) disintegrin and metallopro (633 aa) initn: 294 init1: 145 opt: 397 Z-score: 327.6 bits: 71.1 E(85289): 1.7e-11 Smith-Waterman score: 437; 27.8% identity (50.3% similar) in 431 aa overlap (162-568:134-509) 140 150 160 170 180 pF1KE2 GGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTG-- .: . :: : .. :.. .. : NP_001 QGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP-GDLQGPPIISRIQDLHLPGHT 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE2 -----VEEV-TQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVI : : :: : : : : . .:..: . .: .: .: : .:: . : . .. NP_001 CALSWRESVHTQKPPE-HPL-GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE2 AQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTAD--EKDPTNPFRFPNIGVEKFL . . .::... :. . .. : : : .:. : . .:.:: NP_001 NRTLEVALLLDTFFRPL------NVRVALVGLEAWTQRDLVEISPN-----PAVTLENFL 230 240 250 260 310 320 330 340 350 pF1KE2 E-----LNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKK . : . ::. : . : .:. ..:.: ...:: : .: : . NP_001 HWRRAHLLPRLPHDS---AQLVTGTSFSGPTVGMAI-------QNSIC--SPDFSGGVNM 270 280 290 300 310 360 370 380 390 400 410 pF1KE2 SLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHD-SGTECT-PGESKNLGQKENGN . .:.:. : . ..:::.::..: :: :. : :: . . NP_001 DHSTSILGVAS------------SIAHELGHSLGLDHDLPGNSCPCPGPAPA------KT 320 330 340 350 420 430 440 450 460 pF1KE2 YIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVE---SGQPI---CGNGMVEQG :: : : : : . .:: :: : . ..: ..:. : : :. ::: .:: : NP_001 CIMEA---STDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPG 360 370 380 390 400 410 470 480 490 500 510 520 pF1KE2 EECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD- :.::::. :.: : :: .. :.:.:: ::. :.:::: .: .. .. .:: NP_001 EQCDCGFLDDCVDPCC------DSLTCQLRPGAQCA-SDGPCCQ-NCQLRPSGWQCRPTR 420 430 440 450 460 530 540 550 560 570 580 pF1KE2 SDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDG .:: .: : .. :: . . : ::..:.:: NP_001 GDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAP 470 480 490 500 510 520 590 600 610 620 630 640 pF1KE2 KDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRL NP_001 LCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETID 530 540 550 560 570 580 748 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 14:12:39 2016 done: Sun Nov 6 14:12:40 2016 Total Scan time: 10.670 Total Display time: 0.180 Function used was FASTA [36.3.4 Apr, 2011]