Result of FASTA (omim) for pF1KE2078
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE2078, 748 aa
  1>>>pF1KE2078 748 - 748 aa - 748 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.5860+/-0.000398; mu= 10.1592+/- 0.025
 mean_var=157.2415+/-30.394, 0's: 0 Z-trim(117.8): 162  B-trim: 43 in 1/53
 Lambda= 0.102280
 statistics sampled from 29905 (30084) to 29905 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.696), E-opt: 0.2 (0.353), width:  16
 Scan time: 10.670

The best scores are:                                      opt bits E(85289)
NP_001101 (OMIM: 602192,615537,615590) disintegrin ( 748) 5277 791.2       0
XP_016877350 (OMIM: 602192,615537,615590) PREDICTE ( 674) 4770 716.3 9.8e-206
NP_001307499 (OMIM: 602192,615537,615590) disinteg ( 717) 3419 517.0 1.1e-145
NP_003174 (OMIM: 603639,614328) disintegrin and me ( 824)  727 119.8 4.4e-26
XP_011508677 (OMIM: 603639,614328) PREDICTED: disi ( 793)  726 119.7 4.8e-26
XP_016860274 (OMIM: 603639,614328) PREDICTED: disi ( 525)  685 113.5 2.3e-24
XP_011508679 (OMIM: 603639,614328) PREDICTED: disi ( 525)  685 113.5 2.3e-24
XP_016860275 (OMIM: 603639,614328) PREDICTED: disi ( 525)  685 113.5 2.3e-24
XP_011508678 (OMIM: 603639,614328) PREDICTED: disi ( 604)  685 113.5 2.6e-24
NP_001248395 (OMIM: 605548) disintegrin and metall ( 633)  397 71.1 1.7e-11
NP_997074 (OMIM: 605548) disintegrin and metallopr ( 772)  397 71.1 1.9e-11
NP_001248394 (OMIM: 605548) disintegrin and metall ( 796)  397 71.1   2e-11
NP_003806 (OMIM: 605548) disintegrin and metallopr ( 814)  397 71.1   2e-11
NP_001248393 (OMIM: 605548) disintegrin and metall ( 824)  397 71.1   2e-11
NP_997078 (OMIM: 605548) disintegrin and metallopr ( 838)  397 71.1 2.1e-11
NP_997077 (OMIM: 605548) disintegrin and metallopr ( 839)  397 71.1 2.1e-11
NP_997079 (OMIM: 605548) disintegrin and metallopr ( 862)  397 71.2 2.1e-11
NP_997080 (OMIM: 605548) disintegrin and metallopr ( 863)  397 71.2 2.1e-11
XP_011527672 (OMIM: 607114) PREDICTED: disintegrin ( 635)  374 67.7 1.7e-10
XP_011527675 (OMIM: 607114) PREDICTED: disintegrin ( 492)  372 67.3 1.8e-10
NP_694882 (OMIM: 607114) disintegrin and metallopr ( 787)  373 67.6 2.3e-10
XP_011527670 (OMIM: 607114) PREDICTED: disintegrin ( 800)  373 67.6 2.3e-10
XP_011527669 (OMIM: 607114) PREDICTED: disintegrin ( 812)  373 67.6 2.3e-10
NP_001269376 (OMIM: 607114) disintegrin and metall ( 812)  373 67.6 2.3e-10
NP_079496 (OMIM: 607114) disintegrin and metallopr ( 813)  373 67.6 2.3e-10
XP_011527668 (OMIM: 607114) PREDICTED: disintegrin ( 825)  373 67.6 2.4e-10
XP_006723702 (OMIM: 607114) PREDICTED: disintegrin ( 825)  373 67.6 2.4e-10
XP_005260900 (OMIM: 607114) PREDICTED: disintegrin ( 826)  373 67.6 2.4e-10
XP_006723703 (OMIM: 607114) PREDICTED: disintegrin ( 823)  372 67.4 2.6e-10
XP_011542984 (OMIM: 602713,612775) PREDICTED: disi ( 801)  364 66.3 5.8e-10
NP_003807 (OMIM: 602713,612775) disintegrin and me ( 819)  364 66.3 5.9e-10
XP_016869431 (OMIM: 602713,612775) PREDICTED: disi ( 821)  364 66.3 5.9e-10
XP_016865498 (OMIM: 603640) PREDICTED: disintegrin ( 651)  338 62.4   7e-09
XP_011532984 (OMIM: 603640) PREDICTED: disintegrin ( 651)  338 62.4   7e-09
NP_001265043 (OMIM: 601533) disintegrin and metall ( 672)  336 62.1 8.9e-09
NP_150377 (OMIM: 603640) disintegrin and metallopr ( 918)  338 62.5 9.2e-09
XP_005266060 (OMIM: 603640) PREDICTED: disintegrin ( 955)  338 62.5 9.5e-09
XP_011542782 (OMIM: 601533) PREDICTED: disintegrin ( 579)  329 61.0 1.6e-08
XP_005273525 (OMIM: 601533) PREDICTED: disintegrin ( 705)  329 61.1 1.9e-08
XP_011542673 (OMIM: 606188) PREDICTED: disintegrin ( 522)  319 59.5 4.1e-08
NP_068547 (OMIM: 606188) disintegrin and metallopr ( 540)  319 59.5 4.3e-08
XP_011542672 (OMIM: 606188) PREDICTED: disintegrin ( 542)  319 59.5 4.3e-08
NP_001275904 (OMIM: 602714) disintegrin and metall ( 735)  321 59.9 4.4e-08
NP_001275903 (OMIM: 602714) disintegrin and metall ( 737)  321 59.9 4.4e-08
NP_067673 (OMIM: 602714) disintegrin and metallopr ( 738)  321 59.9 4.4e-08
XP_016872194 (OMIM: 602714) PREDICTED: disintegrin ( 753)  321 59.9 4.5e-08
XP_005273439 (OMIM: 606188) PREDICTED: disintegrin ( 621)  319 59.5 4.7e-08
XP_011542671 (OMIM: 606188) PREDICTED: disintegrin ( 673)  319 59.6 5.1e-08
NP_001275902 (OMIM: 602714) disintegrin and metall ( 906)  321 60.0 5.2e-08
NP_003465 (OMIM: 602714) disintegrin and metallopr ( 909)  321 60.0 5.2e-08


>>NP_001101 (OMIM: 602192,615537,615590) disintegrin and  (748 aa)
 initn: 5277 init1: 5277 opt: 5277  Z-score: 4218.3  bits: 791.2 E(85289):    0
Smith-Waterman score: 5277; 100.0% identity (100.0% similar) in 748 aa overlap (1-748:1-748)

               10        20        30        40        50        60
pF1KE2 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
              670       680       690       700       710       720

              730       740        
pF1KE2 KRRRPPQPIQQPQRQRPRESYQMGHMRR
       ::::::::::::::::::::::::::::
NP_001 KRRRPPQPIQQPQRQRPRESYQMGHMRR
              730       740        

>>XP_016877350 (OMIM: 602192,615537,615590) PREDICTED: d  (674 aa)
 initn: 4770 init1: 4770 opt: 4770  Z-score: 3814.6  bits: 716.3 E(85289): 9.8e-206
Smith-Waterman score: 4770; 100.0% identity (100.0% similar) in 674 aa overlap (75-748:1-674)

           50        60        70        80        90       100    
pF1KE2 KHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYT
                                     ::::::::::::::::::::::::::::::
XP_016                               MKRDTSLFSDEFKVETSNKVLDYDTSHIYT
                                             10        20        30

          110       120       130       140       150       160    
pF1KE2 GHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYP
               40        50        60        70        80        90

          170       180       190       200       210       220    
pF1KE2 HKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQL
              100       110       120       130       140       150

          230       240       250       260       270       280    
pF1KE2 YIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEK
              160       170       180       190       200       210

          290       300       310       320       330       340    
pF1KE2 DPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGIC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGIC
              220       230       240       250       260       270

          350       360       370       380       390       400    
pF1KE2 EKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGES
              280       290       300       310       320       330

          410       420       430       440       450       460    
pF1KE2 KNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGM
              340       350       360       370       380       390

          470       480       490       500       510       520    
pF1KE2 VEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKC
              400       410       420       430       440       450

          530       540       550       560       570       580    
pF1KE2 RDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCAS
              460       470       480       490       500       510

          590       600       610       620       630       640    
pF1KE2 SDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMR
              520       530       540       550       560       570

          650       660       670       680       690       700    
pF1KE2 CRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTP
              580       590       600       610       620       630

          710       720       730       740        
pF1KE2 SSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR
       ::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR
              640       650       660       670    

>>NP_001307499 (OMIM: 602192,615537,615590) disintegrin   (717 aa)
 initn: 3419 init1: 3419 opt: 3419  Z-score: 2736.8  bits: 517.0 E(85289): 1.1e-145
Smith-Waterman score: 5013; 95.9% identity (95.9% similar) in 748 aa overlap (1-748:1-717)

               10        20        30        40        50        60
pF1KE2 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
       ::::::                               :::::::::::::::::::::::
NP_001 AVIAQI-------------------------------NTTADEKDPTNPFRFPNIGVEKF
                                             250       260         

              310       320       330       340       350       360
pF1KE2 LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
     270       280       290       300       310       320         

              370       380       390       400       410       420
pF1KE2 GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
     330       340       350       360       370       380         

              430       440       450       460       470       480
pF1KE2 ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
     390       400       410       420       430       440         

              490       500       510       520       530       540
pF1KE2 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
     450       460       470       480       490       500         

              550       560       570       580       590       600
pF1KE2 ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
     510       520       530       540       550       560         

              610       620       630       640       650       660
pF1KE2 KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
     570       580       590       600       610       620         

              670       680       690       700       710       720
pF1KE2 IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
     630       640       650       660       670       680         

              730       740        
pF1KE2 KRRRPPQPIQQPQRQRPRESYQMGHMRR
       ::::::::::::::::::::::::::::
NP_001 KRRRPPQPIQQPQRQRPRESYQMGHMRR
     690       700       710       

>>NP_003174 (OMIM: 603639,614328) disintegrin and metall  (824 aa)
 initn: 739 init1: 240 opt: 727  Z-score: 589.2  bits: 119.8 E(85289): 4.4e-26
Smith-Waterman score: 979; 28.0% identity (56.2% similar) in 778 aa overlap (16-742:25-757)

                        10         20        30        40        50
pF1KE2          MVLLRVLILLLSWAAGMGG-QYGNPLNKYIRHYEGLSYNVDSLHQKHQRAK
                               :.:  :  . :.. .  :. :: .  . :. ..:  
NP_003 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDL
               10        20        30        40        50        60

               60        70        80           90       100       
pF1KE2 RAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKV---ETSNKVLDYDTS--HIYTG
       .. .: . .:   : :  :::.: .  .:  ::..:::   . .:.  .: ..   ..::
NP_003 QTSTHVETLL--TFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNES-EYTVKWQDFFTG
               70          80        90       100        110       

         110       120       130       140       150       160     
pF1KE2 HIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPH
       :. ::  :   . . :      :.: :. . .::  :...: :   . ..:. .::.   
NP_003 HVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVND-TKDKRMLVYKSEDIKNVS
       120       130       140       150        160       170      

         170       180       190       200       210       220     
pF1KE2 KYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLY
       .      :.    . .. . ..     : . : :: .    . ....   .  ::::.: 
NP_003 RLQSPKVCG----YLKVDNEELLPKGLVDREPPEELV----HRVKRRADPDPMKNTCKLL
        180           190       200           210       220        

         230       240         250       260         270       280 
pF1KE2 IQTDHLFFKYYGTRE--AVIAQISSHVKAIDTIYQTT--DFSGIRNISFMVKRIRINTTA
       . .:: :..:.:  :  ..   .   .  .: ::..:  : .:... ......:::  . 
NP_003 VVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSP
      230       240       250       260       270       280        

             290                 300          310       320        
pF1KE2 DEKDPTNPFR-----FPN-----IGVEKFLE---LNSEQNHDDYCLAYVFTDRDFDDGVL
       .:  : .        .::       :. .::   ..  .. .  :::..:: .::: :.:
NP_003 QEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTL
      290       300       310       320       330       340        

      330       340        350        360       370       380      
pF1KE2 GLAWVGAPSGSS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHEVG
       :::.::.: ..: ::.: :.     :::.  ::.:. ...:::. .  : . .. .::.:
NP_003 GLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELG
      350       360       370       380       390       400        

        390         400       410       420       430       440    
pF1KE2 HNFGSPHDSG--TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVL
       ::::. ::    .::.:.:..      .:.:.::  :.:::. ::. :: :: ..: ...
NP_003 HNFGAEHDPDGLAECAPNEDQ------GGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTI
      410       420             430       440       450       460  

          450       460       470       480       490       500    
pF1KE2 EKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCS
       :.: ..:: : .. .:::. :..::::: :     .: ::       .  : :: : :::
NP_003 ESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQCS
            470       480       490       500              510     

          510       520         530       540       550       560  
pF1KE2 PSQGPCCTAQCAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVC
         ..:::  .: :.. ..::..  .. :   . :.: .. ::      . : :    . :
NP_003 DRNSPCCK-NCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK-C
         520        530       540       550       560       570    

            570        580       590       600       610       620 
pF1KE2 INGQCAGSICEK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSG
        .:.:   .::.   :: :.:  .:..     :.::: . .. . :.   ... .  :  
NP_003 KDGKCI-PFCEREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF--
            580       590            600         610       620     

             630       640         650           660       670     
pF1KE2 RTITLQPGSPCNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEWIV
           :. :.::.   :.::.  .:  :. :.       . .:.   :.  : .::.  ..
NP_003 ----LRKGKPCT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVL
               630         640       650       660       670       

               680                690       700       710       720
pF1KE2 AH---WW---AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
       .    .:   ..:.  .         .: ..  . ... :    :.. ..  : : : : 
NP_003 VFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQTP
       680       690       700       710        720       730      

              730       740                                        
pF1KE2 KRRRPPQPIQQPQRQRPRESYQMGHMRR                                
        : .:  :.       :. ..:                                      
NP_003 GRLQPA-PVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDL
        740        750       760       770       780       790     

>>XP_011508677 (OMIM: 603639,614328) PREDICTED: disinteg  (793 aa)
 initn: 739 init1: 240 opt: 726  Z-score: 588.6  bits: 119.7 E(85289): 4.8e-26
Smith-Waterman score: 976; 28.0% identity (56.1% similar) in 768 aa overlap (25-742:4-726)

               10        20        30        40        50        60
pF1KE2 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
                               :.. .  :. :: .  . :. ..:  .. .: . .:
XP_011                      MKKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLL
                                    10        20        30         

               70        80           90       100         110     
pF1KE2 RLDFHAHGRHFNLRMKRDTSLFSDEFKV---ETSNKVLDYDTS--HIYTGHIYGEEGSFS
          : :  :::.: .  .:  ::..:::   . .:.  .: ..   ..:::. ::  :  
XP_011 --TFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNES-EYTVKWQDFFTGHVVGEPDSRV
        40        50        60        70         80        90      

         120       130       140       150       160       170     
pF1KE2 HGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCAD
        . . :      :.: :. . .::  :...: :   . ..:. .::.   .      :. 
XP_011 LAHIRDDDVIIRINTDGAEYNIEPLWRFVND-TKDKRMLVYKSEDIKNVSRLQSPKVCG-
        100       110       120        130       140       150     

         180       190       200       210       220       230     
pF1KE2 HSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKY
          . .. . ..     : . : :: .      ....   .  ::::.: . .:: :..:
XP_011 ---YLKVDNEELLPKGLVDREPPEELVHR----VKRRADPDPMKNTCKLLVVADHRFYRY
             160       170       180           190       200       

         240         250       260         270       280       290 
pF1KE2 YGTRE--AVIAQISSHVKAIDTIYQTT--DFSGIRNISFMVKRIRINTTADEKDPTNPFR
       .:  :  ..   .   .  .: ::..:  : .:... ......:::  . .:  : .   
XP_011 MGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHY
       210       220       230       240       250       260       

                       300          310       320       330        
pF1KE2 -----FPN-----IGVEKFLE---LNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSG
            .::       :. .::   ..  .. .  :::..:: .::: :.::::.::.: .
XP_011 NMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRA
       270       280       290       300       310       320       

      340        350        360       370       380       390      
pF1KE2 SS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSG
       .: ::.: :.     :::.  ::.:. ...:::. .  : . .. .::.:::::. ::  
XP_011 NSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPD
       330       340       350       360       370       380       

          400       410       420       430       440       450    
pF1KE2 --TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVE
         .::.:.:...      :.:.::  :.:::. ::. :: :: ..: ...:.: ..:: :
XP_011 GLAECAPNEDQG------GKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQE
       390             400       410       420       430       440 

          460       470       480       490       500       510    
pF1KE2 SGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQ
        .. .:::. :..::::: :     .: ::       .  : :: : :::  ..:::  .
XP_011 RSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQCSDRNSPCCK-N
             450       460       470              480       490    

          520         530       540       550       560       570  
pF1KE2 CAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSIC
       : :.. ..::..  .. :   . :.: .. ::      . : :    . : .:.:   .:
XP_011 CQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK-CKDGKCI-PFC
           500       510       520       530       540         550 

             580       590       600       610       620       630 
pF1KE2 EK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSP
       :.   :: :.:  .:..     :.::: . .. . :.   ... .  :      :. :.:
XP_011 EREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF------LRKGKP
             560            570         580       590              

             640         650           660       670               
pF1KE2 CNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEWIVAH---WW---
       :.   :.::.  .:  :. :.       . .:.   :.  : .::.  ...    .:   
XP_011 CT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPF
      600         610       620       630       640       650      

     680                690       700       710       720       730
pF1KE2 AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQ
       ..:.  .         .: ..  . ... :    :.. ..  : : : :  : .:  :. 
XP_011 SILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQTPGRLQPA-PVI
        660       670       680        690       700       710     

              740                                                  
pF1KE2 QPQRQRPRESYQMGHMRR                                          
             :. ..:                                                
XP_011 PSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEK
          720       730       740       750       760       770    

>>XP_016860274 (OMIM: 603639,614328) PREDICTED: disinteg  (525 aa)
 initn: 545 init1: 240 opt: 685  Z-score: 558.4  bits: 113.5 E(85289): 2.3e-24
Smith-Waterman score: 743; 30.6% identity (58.0% similar) in 474 aa overlap (297-742:19-458)

        270       280       290       300       310       320      
pF1KE2 NISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDG
                                     .:.:  ..  .. .  :::..:: .::: :
XP_016             MAKSYPNEEKDAWDVKMLLEQF-SFDIAEEASKVCLAHLFTYQDFDMG
                           10        20         30        40       

        330       340        350        360       370       380    
pF1KE2 VLGLAWVGAPSGSS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHE
       .::::.::.: ..: ::.: :.     :::.  ::.:. ...:::. .  : . .. .::
XP_016 TLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHE
        50        60        70        80        90       100       

          390         400       410       420       430       440  
pF1KE2 VGHNFGSPHDSG--TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQ
       .:::::. ::    .::.:.:...      :.:.::  :.:::. ::. :: :: ..: .
XP_016 LGHNFGAEHDPDGLAECAPNEDQG------GKYVMYPIAVSGDHENNKMFSNCSKQSIYK
       110       120       130             140       150       160 

            450       460       470       480       490       500  
pF1KE2 VLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQ
       ..:.: ..:: : .. .:::. :..::::: :     .: ::       .  : :: : :
XP_016 TIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQ
             170       180       190       200              210    

            510       520         530       540       550       560
pF1KE2 CSPSQGPCCTAQCAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQ
       ::  ..:::  .: :.. ..::..  .. :   . :.: .. ::      . : :    .
XP_016 CSDRNSPCCK-NCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK
          220        230       240       250       260       270   

              570        580       590       600       610         
pF1KE2 VCINGQCAGSICEK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHF
        : .:.:   .::.   :: :.:  .:..     :.::: . .. . :.   ... .  :
XP_016 -CKDGKCI-PFCEREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF
            280        290       300              310       320    

     620       630       640         650           660       670   
pF1KE2 SGRTITLQPGSPCNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEW
             :. :.::.   :.::.  .:  :. :.       . .:.   :.  : .::.  
XP_016 ------LRKGKPCT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGS
                330         340       350       360       370      

                 680                690       700       710        
pF1KE2 IVAH---WW---AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPG
       ...    .:   ..:.  .         .: ..  . ... :    :.. ..  : : : 
XP_016 VLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQ
        380       390       400       410        420       430     

      720       730       740                                      
pF1KE2 TLKRRRPPQPIQQPQRQRPRESYQMGHMRR                              
       :   :  : :.       :. ..:                                    
XP_016 T-PGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFE
          440       450       460       470       480       490    

>>XP_011508679 (OMIM: 603639,614328) PREDICTED: disinteg  (525 aa)
 initn: 545 init1: 240 opt: 685  Z-score: 558.4  bits: 113.5 E(85289): 2.3e-24
Smith-Waterman score: 743; 30.6% identity (58.0% similar) in 474 aa overlap (297-742:19-458)

        270       280       290       300       310       320      
pF1KE2 NISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDG
                                     .:.:  ..  .. .  :::..:: .::: :
XP_011             MAKSYPNEEKDAWDVKMLLEQF-SFDIAEEASKVCLAHLFTYQDFDMG
                           10        20         30        40       

        330       340        350        360       370       380    
pF1KE2 VLGLAWVGAPSGSS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHE
       .::::.::.: ..: ::.: :.     :::.  ::.:. ...:::. .  : . .. .::
XP_011 TLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHE
        50        60        70        80        90       100       

          390         400       410       420       430       440  
pF1KE2 VGHNFGSPHDSG--TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQ
       .:::::. ::    .::.:.:...      :.:.::  :.:::. ::. :: :: ..: .
XP_011 LGHNFGAEHDPDGLAECAPNEDQG------GKYVMYPIAVSGDHENNKMFSNCSKQSIYK
       110       120       130             140       150       160 

            450       460       470       480       490       500  
pF1KE2 VLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQ
       ..:.: ..:: : .. .:::. :..::::: :     .: ::       .  : :: : :
XP_011 TIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQ
             170       180       190       200              210    

            510       520         530       540       550       560
pF1KE2 CSPSQGPCCTAQCAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQ
       ::  ..:::  .: :.. ..::..  .. :   . :.: .. ::      . : :    .
XP_011 CSDRNSPCCK-NCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK
          220        230       240       250       260       270   

              570        580       590       600       610         
pF1KE2 VCINGQCAGSICEK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHF
        : .:.:   .::.   :: :.:  .:..     :.::: . .. . :.   ... .  :
XP_011 -CKDGKCI-PFCEREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF
            280        290       300              310       320    

     620       630       640         650           660       670   
pF1KE2 SGRTITLQPGSPCNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEW
             :. :.::.   :.::.  .:  :. :.       . .:.   :.  : .::.  
XP_011 ------LRKGKPCT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGS
                330         340       350       360       370      

                 680                690       700       710        
pF1KE2 IVAH---WW---AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPG
       ...    .:   ..:.  .         .: ..  . ... :    :.. ..  : : : 
XP_011 VLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQ
        380       390       400       410        420       430     

      720       730       740                                      
pF1KE2 TLKRRRPPQPIQQPQRQRPRESYQMGHMRR                              
       :   :  : :.       :. ..:                                    
XP_011 T-PGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFE
          440       450       460       470       480       490    

>>XP_016860275 (OMIM: 603639,614328) PREDICTED: disinteg  (525 aa)
 initn: 545 init1: 240 opt: 685  Z-score: 558.4  bits: 113.5 E(85289): 2.3e-24
Smith-Waterman score: 743; 30.6% identity (58.0% similar) in 474 aa overlap (297-742:19-458)

        270       280       290       300       310       320      
pF1KE2 NISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDG
                                     .:.:  ..  .. .  :::..:: .::: :
XP_016             MAKSYPNEEKDAWDVKMLLEQF-SFDIAEEASKVCLAHLFTYQDFDMG
                           10        20         30        40       

        330       340        350        360       370       380    
pF1KE2 VLGLAWVGAPSGSS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHE
       .::::.::.: ..: ::.: :.     :::.  ::.:. ...:::. .  : . .. .::
XP_016 TLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHE
        50        60        70        80        90       100       

          390         400       410       420       430       440  
pF1KE2 VGHNFGSPHDSG--TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQ
       .:::::. ::    .::.:.:...      :.:.::  :.:::. ::. :: :: ..: .
XP_016 LGHNFGAEHDPDGLAECAPNEDQG------GKYVMYPIAVSGDHENNKMFSNCSKQSIYK
       110       120       130             140       150       160 

            450       460       470       480       490       500  
pF1KE2 VLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQ
       ..:.: ..:: : .. .:::. :..::::: :     .: ::       .  : :: : :
XP_016 TIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQ
             170       180       190       200              210    

            510       520         530       540       550       560
pF1KE2 CSPSQGPCCTAQCAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQ
       ::  ..:::  .: :.. ..::..  .. :   . :.: .. ::      . : :    .
XP_016 CSDRNSPCCK-NCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK
          220        230       240       250       260       270   

              570        580       590       600       610         
pF1KE2 VCINGQCAGSICEK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHF
        : .:.:   .::.   :: :.:  .:..     :.::: . .. . :.   ... .  :
XP_016 -CKDGKCI-PFCEREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF
            280        290       300              310       320    

     620       630       640         650           660       670   
pF1KE2 SGRTITLQPGSPCNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEW
             :. :.::.   :.::.  .:  :. :.       . .:.   :.  : .::.  
XP_016 ------LRKGKPCT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGS
                330         340       350       360       370      

                 680                690       700       710        
pF1KE2 IVAH---WW---AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPG
       ...    .:   ..:.  .         .: ..  . ... :    :.. ..  : : : 
XP_016 VLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQ
        380       390       400       410        420       430     

      720       730       740                                      
pF1KE2 TLKRRRPPQPIQQPQRQRPRESYQMGHMRR                              
       :   :  : :.       :. ..:                                    
XP_016 T-PGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFE
          440       450       460       470       480       490    

>>XP_011508678 (OMIM: 603639,614328) PREDICTED: disinteg  (604 aa)
 initn: 617 init1: 240 opt: 685  Z-score: 557.6  bits: 113.5 E(85289): 2.6e-24
Smith-Waterman score: 838; 29.9% identity (57.6% similar) in 569 aa overlap (219-742:2-537)

      190       200       210       220       230       240        
pF1KE2 GVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE--AVIAQI
                                     ::::.: . .:: :..:.:  :  ..   .
XP_011                              MKNTCKLLVVADHRFYRYMGRGEESTTTNYL
                                            10        20        30 

        250       260         270       280       290              
pF1KE2 SSHVKAIDTIYQTT--DFSGIRNISFMVKRIRINTTADEKDPTNPFR-----FPN-----
          .  .: ::..:  : .:... ......:::  . .:  : .        .::     
XP_011 IELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDA
              40        50        60        70        80        90 

          300          310       320       330       340        350
pF1KE2 IGVEKFLE---LNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSS-GGICEKSKLY
         :. .::   ..  .. .  :::..:: .::: :.::::.::.: ..: ::.: :.   
XP_011 WDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYS
             100       110       120       130       140       150 

               360       370       380       390         400       
pF1KE2 SDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSG--TECTPGESKNL
         :::.  ::.:. ...:::. .  : . .. .::.:::::. ::    .::.:.:... 
XP_011 PVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQG-
             160       170       180       190       200       210 

       410       420       430       440       450       460       
pF1KE2 GQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQ
            :.:.::  :.:::. ::. :: :: ..: ...:.: ..:: : .. .:::. :..
XP_011 -----GKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDE
                   220       230       240       250       260     

       470       480       490       500       510       520       
pF1KE2 GEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRD-
       ::::: :     .: ::       .  : :: : :::  ..:::  .: :.. ..::.. 
XP_011 GEECDPGIMYLNNDTCC-------NSDCTLKEGVQCSDRNSPCCK-NCQFETAQKKCQEA
         270       280              290       300        310       

         530       540       550       560       570        580    
pF1KE2 -DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEK-YGLEECTCAS
        .. :   . :.: .. ::      . : :    . : .:.:   .::.   :: :.:  
XP_011 INATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK-CKDGKCI-PFCEREQQLESCACNE
       320       330       340       350         360       370     

          590       600       610       620       630       640    
pF1KE2 SDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMR
       .:..     :.::: . .. . :.   ... .  :      :. :.::.   :.::.  .
XP_011 TDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF------LRKGKPCT--VGFCDMNGK
              380         390       400             410         420

            650           660       670             680            
pF1KE2 C--RLVDAD----GPLARLKKAIFSPELYENIAEWIVAH---WW---AVLLMGI------
       :  :. :.       . .:.   :.  : .::.  ...    .:   ..:.  .      
XP_011 CEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDK
              430       440       450       460       470       480

           690       700       710       720       730       740   
pF1KE2 ---ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQM
          .: ..  . ... :    :.. ..  : : : :  : .:  :.       :. ..: 
XP_011 QYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQTPGRLQPA-PVIPSAPAAPKLDHQR
              490        500       510       520        530        

                                                                   
pF1KE2 GHMRR                                                       
                                                                   
XP_011 MDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVD
      540       550       560       570       580       590        

>>NP_001248395 (OMIM: 605548) disintegrin and metallopro  (633 aa)
 initn: 294 init1: 145 opt: 397  Z-score: 327.6  bits: 71.1 E(85289): 1.7e-11
Smith-Waterman score: 437; 27.8% identity (50.3% similar) in 431 aa overlap (162-568:134-509)

             140       150       160       170       180           
pF1KE2 GGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTG--
                                     .:  . :: :      .. :..  .. :  
NP_001 QGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP-GDLQGPPIISRIQDLHLPGHT
           110       120       130       140        150       160  

          190        200       210       220       230       240   
pF1KE2 -----VEEV-TQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVI
             : : :: : : :   : . .:..: . .: .: .: : .::   . :   . ..
NP_001 CALSWRESVHTQKPPE-HPL-GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLL
            170        180        190       200       210       220

           250       260       270       280         290       300 
pF1KE2 AQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTAD--EKDPTNPFRFPNIGVEKFL
        .    .  .::...        :.   .  ..  :  :  : .:.     : . .:.::
NP_001 NRTLEVALLLDTFFRPL------NVRVALVGLEAWTQRDLVEISPN-----PAVTLENFL
              230             240       250       260              

                  310       320       330       340       350      
pF1KE2 E-----LNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKK
       .     :  .  ::.   : . :  .:.  ..:.:        ...::  :  .: : . 
NP_001 HWRRAHLLPRLPHDS---AQLVTGTSFSGPTVGMAI-------QNSIC--SPDFSGGVNM
     270       280          290       300                310       

        360       370       380       390        400        410    
pF1KE2 SLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHD-SGTECT-PGESKNLGQKENGN
       . .:.:. : .            ..:::.::..:  ::  :. :  :: .         .
NP_001 DHSTSILGVAS------------SIAHELGHSLGLDHDLPGNSCPCPGPAPA------KT
       320                   330       340       350               

          420       430       440       450             460        
pF1KE2 YIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVE---SGQPI---CGNGMVEQG
        :: :   : : : . .:: :: : . ..:    ..:. :   :  :.   ::: .:: :
NP_001 CIMEA---STDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPG
     360          370       380       390       400       410      

      470       480       490       500       510       520        
pF1KE2 EECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD-
       :.::::. :.: : ::      ..  :.:.:: ::. :.::::  .: .. .. .::   
NP_001 EQCDCGFLDDCVDPCC------DSLTCQLRPGAQCA-SDGPCCQ-NCQLRPSGWQCRPTR
        420       430             440        450        460        

       530       540       550       560       570       580       
pF1KE2 SDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDG
       .::    .: : .. :: .    .   :     ::..:.::                   
NP_001 GDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAP
      470       480       490       500       510       520        

       590       600       610       620       630       640       
pF1KE2 KDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRL
                                                                   
NP_001 LCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETID
      530       540       550       560       570       580        




748 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 14:12:39 2016 done: Sun Nov  6 14:12:40 2016
 Total Scan time: 10.670 Total Display time:  0.180

Function used was FASTA [36.3.4 Apr, 2011]
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