Result of FASTA (omim) for
pF1KE2078
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2078, 748 aa
1>>>pF1KE2078 748 - 748 aa - 748 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5860+/-0.000398; mu= 10.1592+/- 0.025
mean_var=157.2415+/-30.394, 0's: 0 Z-trim(117.8): 162 B-trim: 43 in 1/53
Lambda= 0.102280
statistics sampled from 29905 (30084) to 29905 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.696), E-opt: 0.2 (0.353), width: 16
Scan time: 10.670
The best scores are: opt bits E(85289)
NP_001101 (OMIM: 602192,615537,615590) disintegrin ( 748) 5277 791.2 0
XP_016877350 (OMIM: 602192,615537,615590) PREDICTE ( 674) 4770 716.3 9.8e-206
NP_001307499 (OMIM: 602192,615537,615590) disinteg ( 717) 3419 517.0 1.1e-145
NP_003174 (OMIM: 603639,614328) disintegrin and me ( 824) 727 119.8 4.4e-26
XP_011508677 (OMIM: 603639,614328) PREDICTED: disi ( 793) 726 119.7 4.8e-26
XP_016860274 (OMIM: 603639,614328) PREDICTED: disi ( 525) 685 113.5 2.3e-24
XP_011508679 (OMIM: 603639,614328) PREDICTED: disi ( 525) 685 113.5 2.3e-24
XP_016860275 (OMIM: 603639,614328) PREDICTED: disi ( 525) 685 113.5 2.3e-24
XP_011508678 (OMIM: 603639,614328) PREDICTED: disi ( 604) 685 113.5 2.6e-24
NP_001248395 (OMIM: 605548) disintegrin and metall ( 633) 397 71.1 1.7e-11
NP_997074 (OMIM: 605548) disintegrin and metallopr ( 772) 397 71.1 1.9e-11
NP_001248394 (OMIM: 605548) disintegrin and metall ( 796) 397 71.1 2e-11
NP_003806 (OMIM: 605548) disintegrin and metallopr ( 814) 397 71.1 2e-11
NP_001248393 (OMIM: 605548) disintegrin and metall ( 824) 397 71.1 2e-11
NP_997078 (OMIM: 605548) disintegrin and metallopr ( 838) 397 71.1 2.1e-11
NP_997077 (OMIM: 605548) disintegrin and metallopr ( 839) 397 71.1 2.1e-11
NP_997079 (OMIM: 605548) disintegrin and metallopr ( 862) 397 71.2 2.1e-11
NP_997080 (OMIM: 605548) disintegrin and metallopr ( 863) 397 71.2 2.1e-11
XP_011527672 (OMIM: 607114) PREDICTED: disintegrin ( 635) 374 67.7 1.7e-10
XP_011527675 (OMIM: 607114) PREDICTED: disintegrin ( 492) 372 67.3 1.8e-10
NP_694882 (OMIM: 607114) disintegrin and metallopr ( 787) 373 67.6 2.3e-10
XP_011527670 (OMIM: 607114) PREDICTED: disintegrin ( 800) 373 67.6 2.3e-10
XP_011527669 (OMIM: 607114) PREDICTED: disintegrin ( 812) 373 67.6 2.3e-10
NP_001269376 (OMIM: 607114) disintegrin and metall ( 812) 373 67.6 2.3e-10
NP_079496 (OMIM: 607114) disintegrin and metallopr ( 813) 373 67.6 2.3e-10
XP_011527668 (OMIM: 607114) PREDICTED: disintegrin ( 825) 373 67.6 2.4e-10
XP_006723702 (OMIM: 607114) PREDICTED: disintegrin ( 825) 373 67.6 2.4e-10
XP_005260900 (OMIM: 607114) PREDICTED: disintegrin ( 826) 373 67.6 2.4e-10
XP_006723703 (OMIM: 607114) PREDICTED: disintegrin ( 823) 372 67.4 2.6e-10
XP_011542984 (OMIM: 602713,612775) PREDICTED: disi ( 801) 364 66.3 5.8e-10
NP_003807 (OMIM: 602713,612775) disintegrin and me ( 819) 364 66.3 5.9e-10
XP_016869431 (OMIM: 602713,612775) PREDICTED: disi ( 821) 364 66.3 5.9e-10
XP_016865498 (OMIM: 603640) PREDICTED: disintegrin ( 651) 338 62.4 7e-09
XP_011532984 (OMIM: 603640) PREDICTED: disintegrin ( 651) 338 62.4 7e-09
NP_001265043 (OMIM: 601533) disintegrin and metall ( 672) 336 62.1 8.9e-09
NP_150377 (OMIM: 603640) disintegrin and metallopr ( 918) 338 62.5 9.2e-09
XP_005266060 (OMIM: 603640) PREDICTED: disintegrin ( 955) 338 62.5 9.5e-09
XP_011542782 (OMIM: 601533) PREDICTED: disintegrin ( 579) 329 61.0 1.6e-08
XP_005273525 (OMIM: 601533) PREDICTED: disintegrin ( 705) 329 61.1 1.9e-08
XP_011542673 (OMIM: 606188) PREDICTED: disintegrin ( 522) 319 59.5 4.1e-08
NP_068547 (OMIM: 606188) disintegrin and metallopr ( 540) 319 59.5 4.3e-08
XP_011542672 (OMIM: 606188) PREDICTED: disintegrin ( 542) 319 59.5 4.3e-08
NP_001275904 (OMIM: 602714) disintegrin and metall ( 735) 321 59.9 4.4e-08
NP_001275903 (OMIM: 602714) disintegrin and metall ( 737) 321 59.9 4.4e-08
NP_067673 (OMIM: 602714) disintegrin and metallopr ( 738) 321 59.9 4.4e-08
XP_016872194 (OMIM: 602714) PREDICTED: disintegrin ( 753) 321 59.9 4.5e-08
XP_005273439 (OMIM: 606188) PREDICTED: disintegrin ( 621) 319 59.5 4.7e-08
XP_011542671 (OMIM: 606188) PREDICTED: disintegrin ( 673) 319 59.6 5.1e-08
NP_001275902 (OMIM: 602714) disintegrin and metall ( 906) 321 60.0 5.2e-08
NP_003465 (OMIM: 602714) disintegrin and metallopr ( 909) 321 60.0 5.2e-08
>>NP_001101 (OMIM: 602192,615537,615590) disintegrin and (748 aa)
initn: 5277 init1: 5277 opt: 5277 Z-score: 4218.3 bits: 791.2 E(85289): 0
Smith-Waterman score: 5277; 100.0% identity (100.0% similar) in 748 aa overlap (1-748:1-748)
10 20 30 40 50 60
pF1KE2 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
670 680 690 700 710 720
730 740
pF1KE2 KRRRPPQPIQQPQRQRPRESYQMGHMRR
::::::::::::::::::::::::::::
NP_001 KRRRPPQPIQQPQRQRPRESYQMGHMRR
730 740
>>XP_016877350 (OMIM: 602192,615537,615590) PREDICTED: d (674 aa)
initn: 4770 init1: 4770 opt: 4770 Z-score: 3814.6 bits: 716.3 E(85289): 9.8e-206
Smith-Waterman score: 4770; 100.0% identity (100.0% similar) in 674 aa overlap (75-748:1-674)
50 60 70 80 90 100
pF1KE2 KHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYT
::::::::::::::::::::::::::::::
XP_016 MKRDTSLFSDEFKVETSNKVLDYDTSHIYT
10 20 30
110 120 130 140 150 160
pF1KE2 GHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYP
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE2 HKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQL
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE2 YIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEK
160 170 180 190 200 210
290 300 310 320 330 340
pF1KE2 DPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGIC
220 230 240 250 260 270
350 360 370 380 390 400
pF1KE2 EKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGES
280 290 300 310 320 330
410 420 430 440 450 460
pF1KE2 KNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGM
340 350 360 370 380 390
470 480 490 500 510 520
pF1KE2 VEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKC
400 410 420 430 440 450
530 540 550 560 570 580
pF1KE2 RDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCAS
460 470 480 490 500 510
590 600 610 620 630 640
pF1KE2 SDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMR
520 530 540 550 560 570
650 660 670 680 690 700
pF1KE2 CRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTP
580 590 600 610 620 630
710 720 730 740
pF1KE2 SSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR
::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR
640 650 660 670
>>NP_001307499 (OMIM: 602192,615537,615590) disintegrin (717 aa)
initn: 3419 init1: 3419 opt: 3419 Z-score: 2736.8 bits: 517.0 E(85289): 1.1e-145
Smith-Waterman score: 5013; 95.9% identity (95.9% similar) in 748 aa overlap (1-748:1-717)
10 20 30 40 50 60
pF1KE2 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
:::::: :::::::::::::::::::::::
NP_001 AVIAQI-------------------------------NTTADEKDPTNPFRFPNIGVEKF
250 260
310 320 330 340 350 360
pF1KE2 LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE2 GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE2 ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
390 400 410 420 430 440
490 500 510 520 530 540
pF1KE2 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
450 460 470 480 490 500
550 560 570 580 590 600
pF1KE2 ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
510 520 530 540 550 560
610 620 630 640 650 660
pF1KE2 KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
570 580 590 600 610 620
670 680 690 700 710 720
pF1KE2 IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
630 640 650 660 670 680
730 740
pF1KE2 KRRRPPQPIQQPQRQRPRESYQMGHMRR
::::::::::::::::::::::::::::
NP_001 KRRRPPQPIQQPQRQRPRESYQMGHMRR
690 700 710
>>NP_003174 (OMIM: 603639,614328) disintegrin and metall (824 aa)
initn: 739 init1: 240 opt: 727 Z-score: 589.2 bits: 119.8 E(85289): 4.4e-26
Smith-Waterman score: 979; 28.0% identity (56.2% similar) in 778 aa overlap (16-742:25-757)
10 20 30 40 50
pF1KE2 MVLLRVLILLLSWAAGMGG-QYGNPLNKYIRHYEGLSYNVDSLHQKHQRAK
:.: : . :.. . :. :: . . :. ..:
NP_003 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDL
10 20 30 40 50 60
60 70 80 90 100
pF1KE2 RAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKV---ETSNKVLDYDTS--HIYTG
.. .: . .: : : :::.: . .: ::..::: . .:. .: .. ..::
NP_003 QTSTHVETLL--TFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNES-EYTVKWQDFFTG
70 80 90 100 110
110 120 130 140 150 160
pF1KE2 HIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPH
:. :: : . . : :.: :. . .:: :...: : . ..:. .::.
NP_003 HVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVND-TKDKRMLVYKSEDIKNVS
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 KYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLY
. :. . .. . .. : . : :: . . .... . ::::.:
NP_003 RLQSPKVCG----YLKVDNEELLPKGLVDREPPEELV----HRVKRRADPDPMKNTCKLL
180 190 200 210 220
230 240 250 260 270 280
pF1KE2 IQTDHLFFKYYGTRE--AVIAQISSHVKAIDTIYQTT--DFSGIRNISFMVKRIRINTTA
. .:: :..:.: : .. . . .: ::..: : .:... ......::: .
NP_003 VVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSP
230 240 250 260 270 280
290 300 310 320
pF1KE2 DEKDPTNPFR-----FPN-----IGVEKFLE---LNSEQNHDDYCLAYVFTDRDFDDGVL
.: : . .:: :. .:: .. .. . :::..:: .::: :.:
NP_003 QEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTL
290 300 310 320 330 340
330 340 350 360 370 380
pF1KE2 GLAWVGAPSGSS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHEVG
:::.::.: ..: ::.: :. :::. ::.:. ...:::. . : . .. .::.:
NP_003 GLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELG
350 360 370 380 390 400
390 400 410 420 430 440
pF1KE2 HNFGSPHDSG--TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVL
::::. :: .::.:.:.. .:.:.:: :.:::. ::. :: :: ..: ...
NP_003 HNFGAEHDPDGLAECAPNEDQ------GGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTI
410 420 430 440 450 460
450 460 470 480 490 500
pF1KE2 EKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCS
:.: ..:: : .. .:::. :..::::: : .: :: . : :: : :::
NP_003 ESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQCS
470 480 490 500 510
510 520 530 540 550 560
pF1KE2 PSQGPCCTAQCAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVC
..::: .: :.. ..::.. .. : . :.: .. :: . : : . :
NP_003 DRNSPCCK-NCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK-C
520 530 540 550 560 570
570 580 590 600 610 620
pF1KE2 INGQCAGSICEK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSG
.:.: .::. :: :.: .:.. :.::: . .. . :. ... . :
NP_003 KDGKCI-PFCEREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF--
580 590 600 610 620
630 640 650 660 670
pF1KE2 RTITLQPGSPCNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEWIV
:. :.::. :.::. .: :. :. . .:. :. : .::. ..
NP_003 ----LRKGKPCT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVL
630 640 650 660 670
680 690 700 710 720
pF1KE2 AH---WW---AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
. .: ..:. . .: .. . ... : :.. .. : : : :
NP_003 VFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQTP
680 690 700 710 720 730
730 740
pF1KE2 KRRRPPQPIQQPQRQRPRESYQMGHMRR
: .: :. :. ..:
NP_003 GRLQPA-PVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDL
740 750 760 770 780 790
>>XP_011508677 (OMIM: 603639,614328) PREDICTED: disinteg (793 aa)
initn: 739 init1: 240 opt: 726 Z-score: 588.6 bits: 119.7 E(85289): 4.8e-26
Smith-Waterman score: 976; 28.0% identity (56.1% similar) in 768 aa overlap (25-742:4-726)
10 20 30 40 50 60
pF1KE2 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
:.. . :. :: . . :. ..: .. .: . .:
XP_011 MKKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLL
10 20 30
70 80 90 100 110
pF1KE2 RLDFHAHGRHFNLRMKRDTSLFSDEFKV---ETSNKVLDYDTS--HIYTGHIYGEEGSFS
: : :::.: . .: ::..::: . .:. .: .. ..:::. :: :
XP_011 --TFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNES-EYTVKWQDFFTGHVVGEPDSRV
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE2 HGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCAD
. . : :.: :. . .:: :...: : . ..:. .::. . :.
XP_011 LAHIRDDDVIIRINTDGAEYNIEPLWRFVND-TKDKRMLVYKSEDIKNVSRLQSPKVCG-
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE2 HSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKY
. .. . .. : . : :: . .... . ::::.: . .:: :..:
XP_011 ---YLKVDNEELLPKGLVDREPPEELVHR----VKRRADPDPMKNTCKLLVVADHRFYRY
160 170 180 190 200
240 250 260 270 280 290
pF1KE2 YGTRE--AVIAQISSHVKAIDTIYQTT--DFSGIRNISFMVKRIRINTTADEKDPTNPFR
.: : .. . . .: ::..: : .:... ......::: . .: : .
XP_011 MGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHY
210 220 230 240 250 260
300 310 320 330
pF1KE2 -----FPN-----IGVEKFLE---LNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSG
.:: :. .:: .. .. . :::..:: .::: :.::::.::.: .
XP_011 NMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRA
270 280 290 300 310 320
340 350 360 370 380 390
pF1KE2 SS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSG
.: ::.: :. :::. ::.:. ...:::. . : . .. .::.:::::. ::
XP_011 NSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPD
330 340 350 360 370 380
400 410 420 430 440 450
pF1KE2 --TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVE
.::.:.:... :.:.:: :.:::. ::. :: :: ..: ...:.: ..:: :
XP_011 GLAECAPNEDQG------GKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQE
390 400 410 420 430 440
460 470 480 490 500 510
pF1KE2 SGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQ
.. .:::. :..::::: : .: :: . : :: : ::: ..::: .
XP_011 RSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQCSDRNSPCCK-N
450 460 470 480 490
520 530 540 550 560 570
pF1KE2 CAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSIC
: :.. ..::.. .. : . :.: .. :: . : : . : .:.: .:
XP_011 CQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK-CKDGKCI-PFC
500 510 520 530 540 550
580 590 600 610 620 630
pF1KE2 EK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSP
:. :: :.: .:.. :.::: . .. . :. ... . : :. :.:
XP_011 EREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF------LRKGKP
560 570 580 590
640 650 660 670
pF1KE2 CNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEWIVAH---WW---
:. :.::. .: :. :. . .:. :. : .::. ... .:
XP_011 CT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPF
600 610 620 630 640 650
680 690 700 710 720 730
pF1KE2 AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQ
..:. . .: .. . ... : :.. .. : : : : : .: :.
XP_011 SILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQTPGRLQPA-PVI
660 670 680 690 700 710
740
pF1KE2 QPQRQRPRESYQMGHMRR
:. ..:
XP_011 PSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEK
720 730 740 750 760 770
>>XP_016860274 (OMIM: 603639,614328) PREDICTED: disinteg (525 aa)
initn: 545 init1: 240 opt: 685 Z-score: 558.4 bits: 113.5 E(85289): 2.3e-24
Smith-Waterman score: 743; 30.6% identity (58.0% similar) in 474 aa overlap (297-742:19-458)
270 280 290 300 310 320
pF1KE2 NISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDG
.:.: .. .. . :::..:: .::: :
XP_016 MAKSYPNEEKDAWDVKMLLEQF-SFDIAEEASKVCLAHLFTYQDFDMG
10 20 30 40
330 340 350 360 370 380
pF1KE2 VLGLAWVGAPSGSS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHE
.::::.::.: ..: ::.: :. :::. ::.:. ...:::. . : . .. .::
XP_016 TLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHE
50 60 70 80 90 100
390 400 410 420 430 440
pF1KE2 VGHNFGSPHDSG--TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQ
.:::::. :: .::.:.:... :.:.:: :.:::. ::. :: :: ..: .
XP_016 LGHNFGAEHDPDGLAECAPNEDQG------GKYVMYPIAVSGDHENNKMFSNCSKQSIYK
110 120 130 140 150 160
450 460 470 480 490 500
pF1KE2 VLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQ
..:.: ..:: : .. .:::. :..::::: : .: :: . : :: : :
XP_016 TIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQ
170 180 190 200 210
510 520 530 540 550 560
pF1KE2 CSPSQGPCCTAQCAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQ
:: ..::: .: :.. ..::.. .. : . :.: .. :: . : : .
XP_016 CSDRNSPCCK-NCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK
220 230 240 250 260 270
570 580 590 600 610
pF1KE2 VCINGQCAGSICEK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHF
: .:.: .::. :: :.: .:.. :.::: . .. . :. ... . :
XP_016 -CKDGKCI-PFCEREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF
280 290 300 310 320
620 630 640 650 660 670
pF1KE2 SGRTITLQPGSPCNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEW
:. :.::. :.::. .: :. :. . .:. :. : .::.
XP_016 ------LRKGKPCT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGS
330 340 350 360 370
680 690 700 710
pF1KE2 IVAH---WW---AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPG
... .: ..:. . .: .. . ... : :.. .. : : :
XP_016 VLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQ
380 390 400 410 420 430
720 730 740
pF1KE2 TLKRRRPPQPIQQPQRQRPRESYQMGHMRR
: : : :. :. ..:
XP_016 T-PGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFE
440 450 460 470 480 490
>>XP_011508679 (OMIM: 603639,614328) PREDICTED: disinteg (525 aa)
initn: 545 init1: 240 opt: 685 Z-score: 558.4 bits: 113.5 E(85289): 2.3e-24
Smith-Waterman score: 743; 30.6% identity (58.0% similar) in 474 aa overlap (297-742:19-458)
270 280 290 300 310 320
pF1KE2 NISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDG
.:.: .. .. . :::..:: .::: :
XP_011 MAKSYPNEEKDAWDVKMLLEQF-SFDIAEEASKVCLAHLFTYQDFDMG
10 20 30 40
330 340 350 360 370 380
pF1KE2 VLGLAWVGAPSGSS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHE
.::::.::.: ..: ::.: :. :::. ::.:. ...:::. . : . .. .::
XP_011 TLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHE
50 60 70 80 90 100
390 400 410 420 430 440
pF1KE2 VGHNFGSPHDSG--TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQ
.:::::. :: .::.:.:... :.:.:: :.:::. ::. :: :: ..: .
XP_011 LGHNFGAEHDPDGLAECAPNEDQG------GKYVMYPIAVSGDHENNKMFSNCSKQSIYK
110 120 130 140 150 160
450 460 470 480 490 500
pF1KE2 VLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQ
..:.: ..:: : .. .:::. :..::::: : .: :: . : :: : :
XP_011 TIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQ
170 180 190 200 210
510 520 530 540 550 560
pF1KE2 CSPSQGPCCTAQCAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQ
:: ..::: .: :.. ..::.. .. : . :.: .. :: . : : .
XP_011 CSDRNSPCCK-NCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK
220 230 240 250 260 270
570 580 590 600 610
pF1KE2 VCINGQCAGSICEK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHF
: .:.: .::. :: :.: .:.. :.::: . .. . :. ... . :
XP_011 -CKDGKCI-PFCEREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF
280 290 300 310 320
620 630 640 650 660 670
pF1KE2 SGRTITLQPGSPCNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEW
:. :.::. :.::. .: :. :. . .:. :. : .::.
XP_011 ------LRKGKPCT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGS
330 340 350 360 370
680 690 700 710
pF1KE2 IVAH---WW---AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPG
... .: ..:. . .: .. . ... : :.. .. : : :
XP_011 VLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQ
380 390 400 410 420 430
720 730 740
pF1KE2 TLKRRRPPQPIQQPQRQRPRESYQMGHMRR
: : : :. :. ..:
XP_011 T-PGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFE
440 450 460 470 480 490
>>XP_016860275 (OMIM: 603639,614328) PREDICTED: disinteg (525 aa)
initn: 545 init1: 240 opt: 685 Z-score: 558.4 bits: 113.5 E(85289): 2.3e-24
Smith-Waterman score: 743; 30.6% identity (58.0% similar) in 474 aa overlap (297-742:19-458)
270 280 290 300 310 320
pF1KE2 NISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDG
.:.: .. .. . :::..:: .::: :
XP_016 MAKSYPNEEKDAWDVKMLLEQF-SFDIAEEASKVCLAHLFTYQDFDMG
10 20 30 40
330 340 350 360 370 380
pF1KE2 VLGLAWVGAPSGSS-GGICEKSKLYSDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHE
.::::.::.: ..: ::.: :. :::. ::.:. ...:::. . : . .. .::
XP_016 TLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHE
50 60 70 80 90 100
390 400 410 420 430 440
pF1KE2 VGHNFGSPHDSG--TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQ
.:::::. :: .::.:.:... :.:.:: :.:::. ::. :: :: ..: .
XP_016 LGHNFGAEHDPDGLAECAPNEDQG------GKYVMYPIAVSGDHENNKMFSNCSKQSIYK
110 120 130 140 150 160
450 460 470 480 490 500
pF1KE2 VLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQ
..:.: ..:: : .. .:::. :..::::: : .: :: . : :: : :
XP_016 TIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCC-------NSDCTLKEGVQ
170 180 190 200 210
510 520 530 540 550 560
pF1KE2 CSPSQGPCCTAQCAFKSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQ
:: ..::: .: :.. ..::.. .. : . :.: .. :: . : : .
XP_016 CSDRNSPCCK-NCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK
220 230 240 250 260 270
570 580 590 600 610
pF1KE2 VCINGQCAGSICEK-YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHF
: .:.: .::. :: :.: .:.. :.::: . .. . :. ... . :
XP_016 -CKDGKCI-PFCEREQQLESCACNETDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF
280 290 300 310 320
620 630 640 650 660 670
pF1KE2 SGRTITLQPGSPCNDFRGYCDVFMRC--RLVDAD----GPLARLKKAIFSPELYENIAEW
:. :.::. :.::. .: :. :. . .:. :. : .::.
XP_016 ------LRKGKPCT--VGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGS
330 340 350 360 370
680 690 700 710
pF1KE2 IVAH---WW---AVLLMGI---------ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPG
... .: ..:. . .: .. . ... : :.. .. : : :
XP_016 VLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQ
380 390 400 410 420 430
720 730 740
pF1KE2 TLKRRRPPQPIQQPQRQRPRESYQMGHMRR
: : : :. :. ..:
XP_016 T-PGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFE
440 450 460 470 480 490
>>XP_011508678 (OMIM: 603639,614328) PREDICTED: disinteg (604 aa)
initn: 617 init1: 240 opt: 685 Z-score: 557.6 bits: 113.5 E(85289): 2.6e-24
Smith-Waterman score: 838; 29.9% identity (57.6% similar) in 569 aa overlap (219-742:2-537)
190 200 210 220 230 240
pF1KE2 GVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE--AVIAQI
::::.: . .:: :..:.: : .. .
XP_011 MKNTCKLLVVADHRFYRYMGRGEESTTTNYL
10 20 30
250 260 270 280 290
pF1KE2 SSHVKAIDTIYQTT--DFSGIRNISFMVKRIRINTTADEKDPTNPFR-----FPN-----
. .: ::..: : .:... ......::: . .: : . .::
XP_011 IELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDA
40 50 60 70 80 90
300 310 320 330 340 350
pF1KE2 IGVEKFLE---LNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSS-GGICEKSKLY
:. .:: .. .. . :::..:: .::: :.::::.::.: ..: ::.: :.
XP_011 WDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYS
100 110 120 130 140 150
360 370 380 390 400
pF1KE2 SDGKKK-SLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSG--TECTPGESKNL
:::. ::.:. ...:::. . : . .. .::.:::::. :: .::.:.:...
XP_011 PVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQG-
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE2 GQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQ
:.:.:: :.:::. ::. :: :: ..: ...:.: ..:: : .. .:::. :..
XP_011 -----GKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDE
220 230 240 250 260
470 480 490 500 510 520
pF1KE2 GEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRD-
::::: : .: :: . : :: : ::: ..::: .: :.. ..::..
XP_011 GEECDPGIMYLNNDTCC-------NSDCTLKEGVQCSDRNSPCCK-NCQFETAQKKCQEA
270 280 290 300 310
530 540 550 560 570 580
pF1KE2 -DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEK-YGLEECTCAS
.. : . :.: .. :: . : : . : .:.: .::. :: :.:
XP_011 INATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGK-CKDGKCI-PFCEREQQLESCACNE
320 330 340 350 360 370
590 600 610 620 630 640
pF1KE2 SDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMR
.:.. :.::: . .. . :. ... . : :. :.::. :.::. .
XP_011 TDNS-----CKVCC-RDLS-GRCVPYVDAEQKNLF------LRKGKPCT--VGFCDMNGK
380 390 400 410 420
650 660 670 680
pF1KE2 C--RLVDAD----GPLARLKKAIFSPELYENIAEWIVAH---WW---AVLLMGI------
: :. :. . .:. :. : .::. ... .: ..:. .
XP_011 CEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDK
430 440 450 460 470 480
690 700 710 720 730 740
pF1KE2 ---ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQM
.: .. . ... : :.. .. : : : : : .: :. :. ..:
XP_011 QYESLSLFHPSNVEMLS-SMDSASVRIIKPFPAPQTPGRLQPA-PVIPSAPAAPKLDHQR
490 500 510 520 530
pF1KE2 GHMRR
XP_011 MDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVD
540 550 560 570 580 590
>>NP_001248395 (OMIM: 605548) disintegrin and metallopro (633 aa)
initn: 294 init1: 145 opt: 397 Z-score: 327.6 bits: 71.1 E(85289): 1.7e-11
Smith-Waterman score: 437; 27.8% identity (50.3% similar) in 431 aa overlap (162-568:134-509)
140 150 160 170 180
pF1KE2 GGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTG--
.: . :: : .. :.. .. :
NP_001 QGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP-GDLQGPPIISRIQDLHLPGHT
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE2 -----VEEV-TQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVI
: : :: : : : : . .:..: . .: .: .: : .:: . : . ..
NP_001 CALSWRESVHTQKPPE-HPL-GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE2 AQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTAD--EKDPTNPFRFPNIGVEKFL
. . .::... :. . .. : : : .:. : . .:.::
NP_001 NRTLEVALLLDTFFRPL------NVRVALVGLEAWTQRDLVEISPN-----PAVTLENFL
230 240 250 260
310 320 330 340 350
pF1KE2 E-----LNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKK
. : . ::. : . : .:. ..:.: ...:: : .: : .
NP_001 HWRRAHLLPRLPHDS---AQLVTGTSFSGPTVGMAI-------QNSIC--SPDFSGGVNM
270 280 290 300 310
360 370 380 390 400 410
pF1KE2 SLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHD-SGTECT-PGESKNLGQKENGN
. .:.:. : . ..:::.::..: :: :. : :: . .
NP_001 DHSTSILGVAS------------SIAHELGHSLGLDHDLPGNSCPCPGPAPA------KT
320 330 340 350
420 430 440 450 460
pF1KE2 YIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVE---SGQPI---CGNGMVEQG
:: : : : : . .:: :: : . ..: ..:. : : :. ::: .:: :
NP_001 CIMEA---STDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPG
360 370 380 390 400 410
470 480 490 500 510 520
pF1KE2 EECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD-
:.::::. :.: : :: .. :.:.:: ::. :.:::: .: .. .. .::
NP_001 EQCDCGFLDDCVDPCC------DSLTCQLRPGAQCA-SDGPCCQ-NCQLRPSGWQCRPTR
420 430 440 450 460
530 540 550 560 570 580
pF1KE2 SDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDG
.:: .: : .. :: . . : ::..:.::
NP_001 GDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAP
470 480 490 500 510 520
590 600 610 620 630 640
pF1KE2 KDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRL
NP_001 LCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETID
530 540 550 560 570 580
748 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 14:12:39 2016 done: Sun Nov 6 14:12:40 2016
Total Scan time: 10.670 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]