FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2202, 943 aa 1>>>pF1KE2202 943 - 943 aa - 943 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.5807+/-0.000522; mu= 5.4046+/- 0.032 mean_var=172.8157+/-35.655, 0's: 0 Z-trim(113.7): 60 B-trim: 571 in 2/48 Lambda= 0.097562 statistics sampled from 23090 (23120) to 23090 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.62), E-opt: 0.2 (0.271), width: 16 Scan time: 10.030 The best scores are: opt bits E(85289) NP_001803 (OMIM: 117141) centromere protein C [Hom ( 943) 6151 879.2 0 XP_006714127 (OMIM: 117141) PREDICTED: centromere ( 935) 6070 867.8 0 XP_011529844 (OMIM: 117141) PREDICTED: centromere ( 772) 4964 712.1 2.7e-204 >>NP_001803 (OMIM: 117141) centromere protein C [Homo sa (943 aa) initn: 6151 init1: 6151 opt: 6151 Z-score: 4690.4 bits: 879.2 E(85289): 0 Smith-Waterman score: 6151; 100.0% identity (100.0% similar) in 943 aa overlap (1-943:1-943) 10 20 30 40 50 60 pF1KE2 MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 RETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 GSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 DEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLAN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 DKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 QRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 VGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 YSNSSVRNELPMHHNSSRKSTKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YSNSSVRNELPMHHNSSRKSTKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 GGIVGHDEISRCSLSEPLESDEADLAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGIVGHDEISRCSLSEPLESDEADLAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 YTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 KNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSK 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 RKAKENIGKVNKKSNKKRICLDNDERKTNLMVNLGIPLGDPLQPTRVKDPETREIILMDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKAKENIGKVNKKSNKKRICLDNDERKTNLMVNLGIPLGDPLQPTRVKDPETREIILMDL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 VRPQDTYQFFVKHGELKVYKTLDTPFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRPQDTYQFFVKHGELKVYKTLDTPFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLL 850 860 870 880 890 900 910 920 930 940 pF1KE2 CTLHETPYILSTGDSFYVPSGNYYNIKNLRNEESVLLFTQIKR ::::::::::::::::::::::::::::::::::::::::::: NP_001 CTLHETPYILSTGDSFYVPSGNYYNIKNLRNEESVLLFTQIKR 910 920 930 940 >>XP_006714127 (OMIM: 117141) PREDICTED: centromere prot (935 aa) initn: 5241 init1: 5241 opt: 6070 Z-score: 4628.8 bits: 867.8 E(85289): 0 Smith-Waterman score: 6070; 99.0% identity (99.2% similar) in 943 aa overlap (1-943:1-935) 10 20 30 40 50 60 pF1KE2 MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 RETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 GSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 DEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLAN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 DKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 QRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 VGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 YSNSSVRNELPMHHNSSRKSTKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YSNSSVRNELPMHHNSSRKSTKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 GGIVGHDEISRCSLSEPLESDEADLAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GGIVGHDEISRCSLSEPLESDEADLAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 YTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 KNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSK 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 RKAKENIGKVNKKSNKKRICLDNDERKTNLMVNLGIPLGDPLQPTRVKDPETREIILMDL ::::::::::::::::::::::::::. ::::::::::::::::::::::::: XP_006 RKAKENIGKVNKKSNKKRICLDNDERS--------IPLGDPLQPTRVKDPETREIILMDL 790 800 810 820 830 850 860 870 880 890 900 pF1KE2 VRPQDTYQFFVKHGELKVYKTLDTPFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VRPQDTYQFFVKHGELKVYKTLDTPFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLL 840 850 860 870 880 890 910 920 930 940 pF1KE2 CTLHETPYILSTGDSFYVPSGNYYNIKNLRNEESVLLFTQIKR ::::::::::::::::::::::::::::::::::::::::::: XP_006 CTLHETPYILSTGDSFYVPSGNYYNIKNLRNEESVLLFTQIKR 900 910 920 930 >>XP_011529844 (OMIM: 117141) PREDICTED: centromere prot (772 aa) initn: 4963 init1: 4963 opt: 4964 Z-score: 3788.7 bits: 712.1 E(85289): 2.7e-204 Smith-Waterman score: 4964; 99.0% identity (99.4% similar) in 772 aa overlap (1-772:1-772) 10 20 30 40 50 60 pF1KE2 MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 RETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 GSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 DEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLAN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 DKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 QRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 VGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 YSNSSVRNELPMHHNSSRKSTKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YSNSSVRNELPMHHNSSRKSTKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 GGIVGHDEISRCSLSEPLESDEADLAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGIVGHDEISRCSLSEPLESDEADLAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 YTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 KNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSK :::::::::::::::::::::::::::::::::::::::::::. : .. XP_011 KNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSAECCYSCII 730 740 750 760 770 790 800 810 820 830 840 pF1KE2 RKAKENIGKVNKKSNKKRICLDNDERKTNLMVNLGIPLGDPLQPTRVKDPETREIILMDL 943 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 00:32:29 2016 done: Tue Nov 8 00:32:30 2016 Total Scan time: 10.030 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]