Result of FASTA (omim) for
pF1KE2307
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2307, 302 aa
1>>>pF1KE2307 302 - 302 aa - 302 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8097+/-0.0004; mu= 14.1744+/- 0.025
mean_var=127.6266+/-33.584, 0's: 0 Z-trim(113.3): 218 B-trim: 1359 in 1/52
Lambda= 0.113528
statistics sampled from 22257 (22572) to 22257 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.615), E-opt: 0.2 (0.265), width: 16
Scan time: 7.360
The best scores are: opt bits E(85289)
NP_001137300 (OMIM: 606792) histamine H4 receptor ( 302) 2002 339.4 5.4e-93
NP_067637 (OMIM: 606792) histamine H4 receptor iso ( 390) 1612 275.6 1.1e-73
NP_001153638 (OMIM: 606792) histamine H4 receptor ( 67) 392 74.9 4.8e-14
XP_011524435 (OMIM: 606792) PREDICTED: histamine H ( 127) 393 75.4 6.5e-14
XP_016883112 (OMIM: 604525) PREDICTED: histamine H ( 399) 351 69.1 1.6e-11
NP_009163 (OMIM: 604525) histamine H3 receptor [Ho ( 445) 351 69.2 1.7e-11
XP_005260323 (OMIM: 604525) PREDICTED: histamine H ( 453) 351 69.2 1.8e-11
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 241 51.3 5.5e-06
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 235 50.2 1e-05
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 230 49.3 1.6e-05
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 230 49.3 1.6e-05
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 230 49.3 1.6e-05
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 230 49.4 1.7e-05
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 230 49.4 1.7e-05
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 230 49.4 1.7e-05
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 230 49.4 1.7e-05
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 230 49.4 1.7e-05
NP_001091682 (OMIM: 600167) histamine H1 receptor ( 487) 229 49.2 1.9e-05
NP_001091683 (OMIM: 600167) histamine H1 receptor ( 487) 229 49.2 1.9e-05
NP_000852 (OMIM: 600167) histamine H1 receptor [Ho ( 487) 229 49.2 1.9e-05
NP_001091681 (OMIM: 600167) histamine H1 receptor ( 487) 229 49.2 1.9e-05
XP_011531954 (OMIM: 600167) PREDICTED: histamine H ( 487) 229 49.2 1.9e-05
XP_011531955 (OMIM: 600167) PREDICTED: histamine H ( 487) 229 49.2 1.9e-05
XP_016861772 (OMIM: 600167) PREDICTED: histamine H ( 487) 229 49.2 1.9e-05
XP_016861773 (OMIM: 600167) PREDICTED: histamine H ( 487) 229 49.2 1.9e-05
NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 220 47.6 4.4e-05
NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 220 47.6 4.5e-05
NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 220 47.6 4.6e-05
NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 220 47.6 4.6e-05
NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 220 47.7 4.8e-05
NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 220 47.7 4.9e-05
NP_036257 (OMIM: 118496) muscarinic acetylcholine ( 532) 218 47.5 7.1e-05
NP_001307846 (OMIM: 118496) muscarinic acetylcholi ( 532) 218 47.5 7.1e-05
NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422) 214 46.7 9.6e-05
NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 211 46.2 0.00013
NP_000729 (OMIM: 118510) muscarinic acetylcholine ( 460) 205 45.3 0.00028
XP_011543044 (OMIM: 118510) PREDICTED: muscarinic ( 460) 205 45.3 0.00028
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 200 44.3 0.00044
NP_000787 (OMIM: 126451,181500,190300) D(3) dopami ( 400) 200 44.4 0.00045
NP_001269492 (OMIM: 126451,181500,190300) D(3) dop ( 400) 200 44.4 0.00045
XP_016861318 (OMIM: 126451,181500,190300) PREDICTE ( 400) 200 44.4 0.00045
NP_001277738 (OMIM: 126451,181500,190300) D(3) dop ( 400) 200 44.4 0.00045
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 198 44.1 0.00063
NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414) 196 43.7 0.00073
XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) ( 443) 196 43.8 0.00076
NP_000786 (OMIM: 126450,159900) D(2) dopamine rece ( 443) 196 43.8 0.00076
XP_005264808 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 191 42.8 0.0012
XP_011531966 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 191 42.8 0.0012
NP_001309138 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 191 42.8 0.0012
NP_001309137 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 191 42.8 0.0012
>>NP_001137300 (OMIM: 606792) histamine H4 receptor isof (302 aa)
initn: 2002 init1: 2002 opt: 2002 Z-score: 1790.6 bits: 339.4 E(85289): 5.4e-93
Smith-Waterman score: 2002; 100.0% identity (100.0% similar) in 302 aa overlap (1-302:1-302)
10 20 30 40 50 60
pF1KE2 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 DFFVVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFFVVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 SNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 YSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSV
250 260 270 280 290 300
pF1KE2 SS
::
NP_001 SS
>>NP_067637 (OMIM: 606792) histamine H4 receptor isoform (390 aa)
initn: 1612 init1: 1612 opt: 1612 Z-score: 1444.0 bits: 275.6 E(85289): 1.1e-73
Smith-Waterman score: 1612; 97.2% identity (99.2% similar) in 246 aa overlap (57-302:145-390)
30 40 50 60 70 80
pF1KE2 FAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVVSESWKDEGSECEPGFFSEWYI
:. . ...::::::::::::::::::::::
NP_067 SVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYI
120 130 140 150 160 170
90 100 110 120 130 140
pF1KE2 LAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 LAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS
180 190 200 210 220 230
150 160 170 180 190 200
pF1KE2 RRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 RRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVE
240 250 260 270 280 290
210 220 230 240 250 260
pF1KE2 LLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 LLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVN
300 310 320 330 340 350
270 280 290 300
pF1KE2 PLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
::::::::::::::::::::::::::::::::::::
NP_067 PLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
360 370 380 390
>--
initn: 413 init1: 392 opt: 393 Z-score: 365.0 bits: 76.0 E(85289): 1.4e-13
Smith-Waterman score: 393; 56.7% identity (72.4% similar) in 134 aa overlap (1-131:1-132)
10 20 30 40 50 60
pF1KE2 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
10 20 30 40 50 60
70 80 90 100 110
pF1KE2 DFFV--VSESWKDEGSECEPGFFSEWYILAITS-FLEFVIPVILVAYFNMNIYWSLWKRD
:::: .: . : : .: .. .:. .: . : .. .... : :. .
NP_067 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSV--SN
70 80 90 100 110
120 130 140 150 160 170
pF1KE2 HLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRT
.: .: :. .
NP_067 AVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAIT
120 130 140 150 160 170
>>NP_001153638 (OMIM: 606792) histamine H4 receptor isof (67 aa)
initn: 392 init1: 392 opt: 392 Z-score: 373.2 bits: 74.9 E(85289): 4.8e-14
Smith-Waterman score: 392; 100.0% identity (100.0% similar) in 64 aa overlap (1-64:1-64)
10 20 30 40 50 60
pF1KE2 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 DFFVVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLS
::::
NP_001 DFFVGVL
>>XP_011524435 (OMIM: 606792) PREDICTED: histamine H4 re (127 aa)
initn: 406 init1: 392 opt: 393 Z-score: 370.8 bits: 75.4 E(85289): 6.5e-14
Smith-Waterman score: 393; 60.7% identity (75.4% similar) in 122 aa overlap (1-119:1-122)
10 20 30 40 50 60
pF1KE2 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
10 20 30 40 50 60
70 80 90 100 110
pF1KE2 DFFV--VSESWKDEGSECEPGFFSEWYILAITS-FLEFVIPVILVAYFNMNIYWSLWKRD
:::: .: . : : .: .. .:. .: . : .. .... : :. .
XP_011 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 HLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRT
:.
XP_011 HMDDLKF
>>XP_016883112 (OMIM: 604525) PREDICTED: histamine H3 re (399 aa)
initn: 606 init1: 196 opt: 351 Z-score: 327.7 bits: 69.1 E(85289): 1.6e-11
Smith-Waterman score: 393; 32.1% identity (54.7% similar) in 265 aa overlap (72-294:131-385)
50 60 70 80 90 100
pF1KE2 VDKNLRHRSSYFFLNLAISDFFVVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVIL
:: .: :: .::.: .: ::: : .
XP_016 KMLLVWVLAFLLYGPAILSWEYLSGGSSIPEG-HCYAEFFYNWYFLITASTLEFFTPFLS
110 120 130 140 150
110 120
pF1KE2 VAYFNMNIY------------------------------------WSLWKRDHLSRCQSH
:..::..:: :. :.. : :
XP_016 VTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLH
160 170 180 190 200 210
130 140 150 160 170 180
pF1KE2 P---GLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSN
: .::... :.. : .. :... : .: :. .: :: .:. . .:
XP_016 RYGVGEAAVGAEA-GEATLGGGGGGGSVASPTSSSGS-SSRGTERPRSLKRGSKPSASSA
220 230 240 250 260 270
190 200 210 220 230 240
pF1KE2 TIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYS
.. ..: ::: . :: .: : :..:::::.....:..:::::.:. :. .
XP_016 SLEKRMKMVSQS----FTQR--FRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACH
280 290 300 310 320 330
250 260 270 280 290
pF1KE2 SATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKK---QPLPSQHSRS
. : . ::. .::: : :: :::.::::::. :..:: :..: .: :: :
XP_016 GHCVP-DYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCW
340 350 360 370 380 390
300
pF1KE2 VSS
XP_016 KKMKKKTCL
>>NP_009163 (OMIM: 604525) histamine H3 receptor [Homo s (445 aa)
initn: 614 init1: 196 opt: 351 Z-score: 327.2 bits: 69.2 E(85289): 1.7e-11
Smith-Waterman score: 393; 32.1% identity (54.7% similar) in 265 aa overlap (72-294:185-439)
50 60 70 80 90 100
pF1KE2 VDKNLRHRSSYFFLNLAISDFFVVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVIL
:: .: :: .::.: .: ::: : .
NP_009 KMLLVWVLAFLLYGPAILSWEYLSGGSSIPEG-HCYAEFFYNWYFLITASTLEFFTPFLS
160 170 180 190 200 210
110 120
pF1KE2 VAYFNMNIY------------------------------------WSLWKRDHLSRCQSH
:..::..:: :. :.. : :
NP_009 VTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLH
220 230 240 250 260 270
130 140 150 160 170 180
pF1KE2 P---GLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSN
: .::... :.. : .. :... : .: :. .: :: .:. . .:
NP_009 RYGVGEAAVGAEA-GEATLGGGGGGGSVASPTSSSGS-SSRGTERPRSLKRGSKPSASSA
280 290 300 310 320 330
190 200 210 220 230 240
pF1KE2 TIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYS
.. ..: ::: . :: .: : :..:::::.....:..:::::.:. :. .
NP_009 SLEKRMKMVSQS----FTQR--FRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACH
340 350 360 370 380
250 260 270 280 290
pF1KE2 SATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKK---QPLPSQHSRS
. : . ::. .::: : :: :::.::::::. :..:: :..: .: :: :
NP_009 GHCVP-DYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCW
390 400 410 420 430 440
300
pF1KE2 VSS
NP_009 K
>>XP_005260323 (OMIM: 604525) PREDICTED: histamine H3 re (453 aa)
initn: 614 init1: 196 opt: 351 Z-score: 327.1 bits: 69.2 E(85289): 1.8e-11
Smith-Waterman score: 393; 32.1% identity (54.7% similar) in 265 aa overlap (72-294:185-439)
50 60 70 80 90 100
pF1KE2 VDKNLRHRSSYFFLNLAISDFFVVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVIL
:: .: :: .::.: .: ::: : .
XP_005 KMLLVWVLAFLLYGPAILSWEYLSGGSSIPEG-HCYAEFFYNWYFLITASTLEFFTPFLS
160 170 180 190 200 210
110 120
pF1KE2 VAYFNMNIY------------------------------------WSLWKRDHLSRCQSH
:..::..:: :. :.. : :
XP_005 VTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLH
220 230 240 250 260 270
130 140 150 160 170 180
pF1KE2 P---GLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSN
: .::... :.. : .. :... : .: :. .: :: .:. . .:
XP_005 RYGVGEAAVGAEA-GEATLGGGGGGGSVASPTSSSGS-SSRGTERPRSLKRGSKPSASSA
280 290 300 310 320 330
190 200 210 220 230 240
pF1KE2 TIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYS
.. ..: ::: . :: .: : :..:::::.....:..:::::.:. :. .
XP_005 SLEKRMKMVSQS----FTQR--FRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACH
340 350 360 370 380
250 260 270 280 290
pF1KE2 SATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKK---QPLPSQHSRS
. : . ::. .::: : :: :::.::::::. :..:: :..: .: :: :
XP_005 GHCVP-DYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCW
390 400 410 420 430 440
300
pF1KE2 VSS
XP_005 KKMKKKTCL
450
>>NP_000669 (OMIM: 104219) alpha-1D adrenergic receptor (572 aa)
initn: 319 init1: 129 opt: 241 Z-score: 228.5 bits: 51.3 E(85289): 5.5e-06
Smith-Waterman score: 241; 29.8% identity (58.3% similar) in 168 aa overlap (120-286:259-419)
90 100 110 120 130 140
pF1KE2 TSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRS
: :. . .... : .: :. ::
NP_000 VGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVAR-STTRS
230 240 250 260 270 280
150 160 170 180 190 200
pF1KE2 LSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLR
: :... . :: : .. . . ..: .: .: :: : ... :
NP_000 LEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRL-----LKFSR
290 300 310 320 330 340
210 220 230 240 250 260
pF1KE2 ARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLL
.. ::.:::..:::..:: :. .:.. :. :. ... ::: .::: ::::.
NP_000 EKKAAKTLAIVVGVFVLCWFPF-FFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLI
350 360 370 380 390 400
270 280 290 300
pF1KE2 YPLCHKRFQKAFLKIF-CIKKQPLPSQHSRSVSS
:: ..:..:::... :
NP_000 YPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAP
410 420 430 440 450 460
>>NP_000670 (OMIM: 104220) alpha-1B adrenergic receptor (520 aa)
initn: 278 init1: 124 opt: 235 Z-score: 223.7 bits: 50.2 E(85289): 1e-05
Smith-Waterman score: 246; 24.8% identity (53.2% similar) in 314 aa overlap (23-286:54-365)
10 20 30 40 50
pF1KE2 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSY
... :::. :: ::::. . ...:: ..:
NP_000 NFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIV-GNILVILSVACNRHLRTPTNY
30 40 50 60 70 80
60 70 80 90 100
pF1KE2 FFLNLAISD----FFVVSESWKDE--GSECEPGFFSE-WYILAITSFLEFVIPVILVAY-
:..:::..: : :. : : : .: . : . . .. . ..
NP_000 FIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISID
90 100 110 120 130 140
110 120 130 140
pF1KE2 FNMNIYWSLWKRDHLSRCQSHPGLTAV---SSNI------------------CG---HSF
... .:: ..: .. .: .: :. : :: . :
NP_000 RYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPF
150 160 170 180 190 200
150 160 170 180 190
pF1KE2 RGRLSSRRSLSASTEVPASFHSE----RQRRKSSLMFSSRTKM-NSNTIASKMGS--FSQ
. .:: :. : .. . .: ..: . .: ::. .. .. : : .
NP_000 YALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHE
210 220 230 240 250 260
200 210 220 230 240
pF1KE2 SDSVALHQREH-------VELL---RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSS
. . . . : :.:. : .. ::.:.:..:.: .:: :. . . :..:.
NP_000 DTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFST
270 280 290 300 310 320
250 260 270 280 290 300
pF1KE2 ATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIF-CIKKQPLPSQHSRSVSS
: .: ....::: .::: .::..:: :.:..::..:. :
NP_000 LKPPDAV-FKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRL
330 340 350 360 370 380
NP_000 GGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVEL
390 400 410 420 430 440
>>NP_150645 (OMIM: 104221) alpha-1A adrenergic receptor (429 aa)
initn: 276 init1: 115 opt: 230 Z-score: 220.2 bits: 49.3 E(85289): 1.6e-05
Smith-Waterman score: 240; 25.2% identity (51.4% similar) in 329 aa overlap (24-297:36-355)
10 20 30 40 50
pF1KE2 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYF
:. :.. ::: ::::. . ..:. . :.
NP_150 GNASDSSNCTQPPAPVNISKAILLGVILGGLILFGV-LGNILVILSVACHRHLHSVTHYY
10 20 30 40 50 60
60 70 80 90
pF1KE2 FLNLAISDFFVVSES----------------------WKDEGSECEPGFFSEWYILAITS
..:::..:....: : : . . :..:
NP_150 IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR
70 80 90 100 110 120
100 110 120
pF1KE2 FL----EFVIPVILVAYFNMNIY---WSL-----------WKR---DHLSRCQ--SHPGL
.. . :.:.. .. :.: :.. . . :: .::
NP_150 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY
130 140 150 160 170 180
130 140 150 160 170 180
pF1KE2 TAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFS-SRTKMNSNTIASK
. :. : :: :. . . : : . : . ::.: . : ... . : :
NP_150 VLFSA--LG-SFYLPLAIILVMYCRVYVVA--KRESRGLKSGLKTDKSDSEQVTLRIHRK
190 200 210 220 230
190 200 210 220 230 240
pF1KE2 MGSFSQSDSVALHQREH--VELL---RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYS
. . : .. . . : :.:: : .. ::.:.:..: :..:: :. : . ::.
NP_150 NAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP
240 250 260 270 280 290
250 260 270 280 290
pF1KE2 SATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAF---LKIFCI-KKQPLPSQHSR
. :. . ..:.::: ..:: .::..:: ..:.::: :.: :. .:: :.:.
NP_150 DFK-PSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ--SSKHAL
300 310 320 330 340 350
300
pF1KE2 SVSS
NP_150 GYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQ
360 370 380 390 400 410
302 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 13:42:59 2016 done: Sun Nov 6 13:43:00 2016
Total Scan time: 7.360 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]