FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2332, 551 aa 1>>>pF1KE2332 551 - 551 aa - 551 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.0135+/-0.00149; mu= 0.3630+/- 0.085 mean_var=439.1031+/-102.166, 0's: 0 Z-trim(105.8): 468 B-trim: 210 in 1/52 Lambda= 0.061206 statistics sampled from 8042 (8618) to 8042 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.62), E-opt: 0.2 (0.265), width: 16 Scan time: 3.270 The best scores are: opt bits E(32554) CCDS1786.1 EIF2AK2 gene_id:5610|Hs108|chr2 ( 551) 3576 331.7 1.4e-90 CCDS46259.1 EIF2AK2 gene_id:5610|Hs108|chr2 ( 510) 1664 162.8 9.1e-40 >>CCDS1786.1 EIF2AK2 gene_id:5610|Hs108|chr2 (551 aa) initn: 3576 init1: 3576 opt: 3576 Z-score: 1739.6 bits: 331.7 E(32554): 1.4e-90 Smith-Waterman score: 3576; 100.0% identity (100.0% similar) in 551 aa overlap (1-551:1-551) 10 20 30 40 50 60 pF1KE2 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS17 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS17 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS17 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS17 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS17 RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS17 NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS17 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS17 FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS17 LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK 490 500 510 520 530 540 550 pF1KE2 KSPEKNERHTC ::::::::::: CCDS17 KSPEKNERHTC 550 >>CCDS46259.1 EIF2AK2 gene_id:5610|Hs108|chr2 (510 aa) initn: 1703 init1: 1664 opt: 1664 Z-score: 827.5 bits: 162.8 E(32554): 9.1e-40 Smith-Waterman score: 3211; 92.6% identity (92.6% similar) in 551 aa overlap (1-551:1-510) 10 20 30 40 50 60 pF1KE2 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY :::::::::::::::::::::: CCDS46 RSLAPRFDLPDMKETKYTVDKR-------------------------------------- 250 260 310 320 330 340 350 360 pF1KE2 NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 ---KAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 270 280 290 300 310 370 380 390 400 410 420 pF1KE2 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 320 330 340 350 360 370 430 440 450 460 470 480 pF1KE2 FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 380 390 400 410 420 430 490 500 510 520 530 540 pF1KE2 LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK 440 450 460 470 480 490 550 pF1KE2 KSPEKNERHTC ::::::::::: CCDS46 KSPEKNERHTC 500 510 551 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:33:03 2016 done: Sun Nov 6 18:33:04 2016 Total Scan time: 3.270 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]