FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2339, 290 aa 1>>>pF1KE2339 290 - 290 aa - 290 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0041+/-0.000366; mu= 16.7332+/- 0.023 mean_var=63.5557+/-12.869, 0's: 0 Z-trim(112.6): 56 B-trim: 0 in 0/58 Lambda= 0.160878 statistics sampled from 21488 (21544) to 21488 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.628), E-opt: 0.2 (0.253), width: 16 Scan time: 6.140 The best scores are: opt bits E(85289) NP_004083 (OMIM: 602292,616277) enoyl-CoA hydratas ( 290) 1893 448.1 9.4e-126 NP_001689 (OMIM: 250950,600529) methylglutaconyl-C ( 339) 450 113.2 7e-25 XP_005252123 (OMIM: 250950,600529) PREDICTED: meth ( 349) 445 112.0 1.6e-24 XP_011517104 (OMIM: 250950,600529) PREDICTED: meth ( 230) 416 105.2 1.2e-22 XP_016870339 (OMIM: 250950,600529) PREDICTED: meth ( 230) 416 105.2 1.2e-22 NP_001957 (OMIM: 607037,615605) peroxisomal bifunc ( 723) 379 96.9 1.2e-19 XP_016870338 (OMIM: 250950,600529) PREDICTED: meth ( 323) 367 93.9 4.3e-19 NP_001293119 (OMIM: 250950,600529) methylglutacony ( 310) 365 93.4 5.7e-19 XP_006717213 (OMIM: 250950,600529) PREDICTED: meth ( 320) 365 93.5 5.8e-19 XP_005252124 (OMIM: 250950,600529) PREDICTED: meth ( 333) 362 92.8 9.8e-19 XP_005252126 (OMIM: 250950,600529) PREDICTED: meth ( 298) 344 88.6 1.6e-17 XP_016870340 (OMIM: 250950,600529) PREDICTED: meth ( 214) 333 85.9 7.3e-17 NP_932164 (OMIM: 250620,610690) 3-hydroxyisobutyry ( 338) 335 86.5 7.6e-17 NP_055177 (OMIM: 250620,610690) 3-hydroxyisobutyry ( 386) 335 86.5 8.5e-17 XP_011509255 (OMIM: 250620,610690) PREDICTED: 3-hy ( 386) 335 86.5 8.5e-17 NP_000173 (OMIM: 600890,609015,609016) trifunction ( 763) 333 86.3 2e-16 NP_733841 (OMIM: 400016,415000) testis-specific ch ( 540) 316 82.2 2.4e-15 NP_004816 (OMIM: 400018,415000) testis-specific ch ( 541) 312 81.3 4.5e-15 NP_001137443 (OMIM: 603778) chromodomain Y-like pr ( 412) 303 79.1 1.5e-14 NP_001137442 (OMIM: 603778) chromodomain Y-like pr ( 412) 303 79.1 1.5e-14 XP_011513299 (OMIM: 603778) PREDICTED: chromodomai ( 522) 303 79.2 1.9e-14 NP_004815 (OMIM: 603778) chromodomain Y-like prote ( 544) 303 79.2 1.9e-14 NP_004671 (OMIM: 400016,415000) testis-specific ch ( 554) 297 77.8 5.1e-14 XP_016881937 (OMIM: 600696) PREDICTED: delta(3,5)- ( 248) 269 71.1 2.4e-12 NP_001389 (OMIM: 600696) delta(3,5)-Delta(2,4)-die ( 328) 269 71.2 3e-12 NP_001002030 (OMIM: 612136) ethylmalonyl-CoA decar ( 301) 267 70.7 3.9e-12 XP_005267105 (OMIM: 612136) PREDICTED: ethylmalony ( 301) 267 70.7 3.9e-12 XP_005267104 (OMIM: 612136) PREDICTED: ethylmalony ( 301) 267 70.7 3.9e-12 NP_001132982 (OMIM: 612136) ethylmalonyl-CoA decar ( 307) 267 70.7 4e-12 NP_001159482 (OMIM: 608024) enoyl-CoA delta isomer ( 364) 250 66.8 7e-11 NP_006108 (OMIM: 608024) enoyl-CoA delta isomerase ( 364) 250 66.8 7e-11 NP_996667 (OMIM: 608024) enoyl-CoA delta isomerase ( 394) 250 66.8 7.5e-11 XP_011529814 (OMIM: 400016,415000) PREDICTED: test ( 470) 249 66.6 1e-10 XP_011510819 (OMIM: 607037,615605) PREDICTED: pero ( 627) 235 63.5 1.2e-09 NP_001159887 (OMIM: 607037,615605) peroxisomal bif ( 627) 235 63.5 1.2e-09 XP_005252129 (OMIM: 250950,600529) PREDICTED: meth ( 255) 222 60.2 4.8e-09 XP_016866545 (OMIM: 612136) PREDICTED: ethylmalony ( 226) 219 59.5 7e-09 NP_001099014 (OMIM: 612136) ethylmalonyl-CoA decar ( 226) 219 59.5 7e-09 XP_011517102 (OMIM: 250950,600529) PREDICTED: meth ( 265) 217 59.0 1.1e-08 NP_001910 (OMIM: 600305) enoyl-CoA delta isomerase ( 302) 206 56.5 7.2e-08 XP_011534244 (OMIM: 612136) PREDICTED: ethylmalony ( 189) 188 52.2 8.9e-07 NP_001171500 (OMIM: 600305) enoyl-CoA delta isomer ( 285) 150 43.5 0.00056 XP_016865659 (OMIM: 608024) PREDICTED: enoyl-CoA d ( 334) 150 43.6 0.00064 XP_006715020 (OMIM: 608024) PREDICTED: enoyl-CoA d ( 364) 150 43.6 0.00068 >>NP_004083 (OMIM: 602292,616277) enoyl-CoA hydratase, m (290 aa) initn: 1893 init1: 1893 opt: 1893 Z-score: 2378.7 bits: 448.1 E(85289): 9.4e-126 Smith-Waterman score: 1893; 100.0% identity (100.0% similar) in 290 aa overlap (1-290:1-290) 10 20 30 40 50 60 pF1KE2 MAALRVLLSCVRGPLRPPVRCPAWRPFASGANFEYIIAEKRGKNNTVGLIQLNRPKALNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MAALRVLLSCVRGPLRPPVRCPAWRPFASGANFEYIIAEKRGKNNTVGLIQLNRPKALNA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 LCDGLIDELNQALKTFEEDPAVGAIVLTGGDKAFAAGADIKEMQNLSFQDCYSSKFLKHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LCDGLIDELNQALKTFEEDPAVGAIVLTGGDKAFAAGADIKEMQNLSFQDCYSSKFLKHW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 DHLTQVKKPVIAAVNGYAFGGGCELAMMCDIIYAGEKAQFAQPEILIGTIPGAGGTQRLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DHLTQVKKPVIAAVNGYAFGGGCELAMMCDIIYAGEKAQFAQPEILIGTIPGAGGTQRLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 RAVGKSLAMEMVLTGDRISAQDAKQAGLVSKICPVETLVEEAIQCAEKIASNSKIVVAMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RAVGKSLAMEMVLTGDRISAQDAKQAGLVSKICPVETLVEEAIQCAEKIASNSKIVVAMA 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 KESVNAAFEMTLTEGSKLEKKLFYSTFATDDRKEGMTAFVEKRKANFKDQ :::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KESVNAAFEMTLTEGSKLEKKLFYSTFATDDRKEGMTAFVEKRKANFKDQ 250 260 270 280 290 >>NP_001689 (OMIM: 250950,600529) methylglutaconyl-CoA h (339 aa) initn: 353 init1: 264 opt: 450 Z-score: 567.6 bits: 113.2 E(85289): 7e-25 Smith-Waterman score: 450; 32.2% identity (66.3% similar) in 255 aa overlap (43-290:85-339) 20 30 40 50 60 70 pF1KE2 GPLRPPVRCPAWRPFASGANFEYIIAEKRGKNNTVGLIQLNRPKALNALCDGLIDELNQA .: . .. .:: . :.: .:: :..: NP_001 VPAAGGPAPKRGYSSEMKTEDELRVRHLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKA 60 70 80 90 100 110 80 90 100 110 120 pF1KE2 LKTFEEDPAVGAIVLTGG-DKAFAAGADIKEMQNLSFQDC--YSSKFLKHWDHLTQVKKP . ... : : .:.. . : ::::.:: ..: .. . ::. . .... : NP_001 VDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDIANLPVP 120 130 140 150 160 170 130 140 150 160 170 180 pF1KE2 VIAAVNGYAFGGGCELAMMCDIIYAGEKAQFAQPEILIGTIPGAGGTQRLTRAVGKSLAM .:::..: :.::: :::. ::: :. .:... : .. :::.:::::: ::.: ::: NP_001 TIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAK 180 190 200 210 220 230 190 200 210 220 230 240 pF1KE2 EMVLTGDRISAQDAKQAGLVSKICPV----ETLVEEAIQCAEKIASNSKIVVAMAKESVN :..... .....:: .::.:.. .. ..:.. :... .. ... .:: ..: NP_001 ELIFSARVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAIN 240 250 260 270 280 290 250 260 270 280 290 pF1KE2 AAFEMTLTEGSKLEKKLFYSTFATDDRKEGMTAFVEKRKANFKDQ ..:. :. : .:. . .:. : :: ::. :: ::: .: . NP_001 QGMEVDLVTGLAIEEACYAQTIPTKDRLEGLLAFKEKRPPRYKGE 300 310 320 330 >>XP_005252123 (OMIM: 250950,600529) PREDICTED: methylgl (349 aa) initn: 353 init1: 264 opt: 445 Z-score: 561.2 bits: 112.0 E(85289): 1.6e-24 Smith-Waterman score: 445; 32.5% identity (66.7% similar) in 249 aa overlap (49-290:101-349) 20 30 40 50 60 70 pF1KE2 VRCPAWRPFASGANFEYIIAEKRGKNNTVGLIQLNRPKALNALCDGLIDELNQALKTFEE .. .:: . :.: .:: :..:. ... XP_005 MKTEDELRVRHLEEENRDSSSMAADHYRIVVLGINRAYGKNSLSKNLIKMLSKAVDALKS 80 90 100 110 120 130 80 90 100 110 120 130 pF1KE2 DPAVGAIVLTGG-DKAFAAGADIKEMQNLSFQDC--YSSKFLKHWDHLTQVKKPVIAAVN : : .:.. . : ::::.:: ..: .. . ::. . .... :.:::.. XP_005 DKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDIANLPVPTIAAID 140 150 160 170 180 190 140 150 160 170 180 190 pF1KE2 GYAFGGGCELAMMCDIIYAGEKAQFAQPEILIGTIPGAGGTQRLTRAVGKSLAMEMVLTG : :.::: :::. ::: :. .:... : .. :::.:::::: ::.: ::: :..... XP_005 GLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSA 200 210 220 230 240 250 200 210 220 230 240 250 pF1KE2 DRISAQDAKQAGLVSKICPV----ETLVEEAIQCAEKIASNSKIVVAMAKESVNAAFEMT .....:: .::.:.. .. ..:.. :... .. ... .:: ..: ..:. XP_005 RVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVD 260 270 280 290 300 310 260 270 280 290 pF1KE2 LTEGSKLEKKLFYSTFATDDRKEGMTAFVEKRKANFKDQ :. : .:. . .:. : :: ::. :: ::: .: . XP_005 LVTGLAIEEACYAQTIPTKDRLEGLLAFKEKRPPRYKGE 320 330 340 >>XP_011517104 (OMIM: 250950,600529) PREDICTED: methylgl (230 aa) initn: 353 init1: 264 opt: 416 Z-score: 527.4 bits: 105.2 E(85289): 1.2e-22 Smith-Waterman score: 416; 32.8% identity (67.2% similar) in 229 aa overlap (69-290:2-230) 40 50 60 70 80 90 pF1KE2 EKRGKNNTVGLIQLNRPKALNALCDGLIDELNQALKTFEEDPAVGAIVLTGG-DKAFAAG :..:. ... : : .:.. . : :: XP_011 MLSKAVDALKSDKKVRTIIIRSEVPGIFCAG 10 20 30 100 110 120 130 140 150 pF1KE2 ADIKEMQNLSFQDC--YSSKFLKHWDHLTQVKKPVIAAVNGYAFGGGCELAMMCDIIYAG ::.:: ..: .. . ::. . .... :.:::..: :.::: :::. ::: :. XP_011 ADLKERAKMSSSEVGPFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAA 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE2 EKAQFAQPEILIGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKICPV .:... : .. :::.:::::: ::.: ::: :..... .....:: .::.:.. XP_011 SSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQ 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE2 ----ETLVEEAIQCAEKIASNSKIVVAMAKESVNAAFEMTLTEGSKLEKKLFYSTFATDD .. ..:.. :... .. ... .:: ..: ..:. :. : .:. . .:. : : XP_011 NQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKD 160 170 180 190 200 210 280 290 pF1KE2 RKEGMTAFVEKRKANFKDQ : ::. :: ::: .: . XP_011 RLEGLLAFKEKRPPRYKGE 220 230 >>XP_016870339 (OMIM: 250950,600529) PREDICTED: methylgl (230 aa) initn: 353 init1: 264 opt: 416 Z-score: 527.4 bits: 105.2 E(85289): 1.2e-22 Smith-Waterman score: 416; 32.8% identity (67.2% similar) in 229 aa overlap (69-290:2-230) 40 50 60 70 80 90 pF1KE2 EKRGKNNTVGLIQLNRPKALNALCDGLIDELNQALKTFEEDPAVGAIVLTGG-DKAFAAG :..:. ... : : .:.. . : :: XP_016 MLSKAVDALKSDKKVRTIIIRSEVPGIFCAG 10 20 30 100 110 120 130 140 150 pF1KE2 ADIKEMQNLSFQDC--YSSKFLKHWDHLTQVKKPVIAAVNGYAFGGGCELAMMCDIIYAG ::.:: ..: .. . ::. . .... :.:::..: :.::: :::. ::: :. XP_016 ADLKERAKMSSSEVGPFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAA 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE2 EKAQFAQPEILIGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKICPV .:... : .. :::.:::::: ::.: ::: :..... .....:: .::.:.. XP_016 SSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQ 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE2 ----ETLVEEAIQCAEKIASNSKIVVAMAKESVNAAFEMTLTEGSKLEKKLFYSTFATDD .. ..:.. :... .. ... .:: ..: ..:. :. : .:. . .:. : : XP_016 NQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKD 160 170 180 190 200 210 280 290 pF1KE2 RKEGMTAFVEKRKANFKDQ : ::. :: ::: .: . XP_016 RLEGLLAFKEKRPPRYKGE 220 230 >>NP_001957 (OMIM: 607037,615605) peroxisomal bifunction (723 aa) initn: 419 init1: 257 opt: 379 Z-score: 473.8 bits: 96.9 E(85289): 1.2e-19 Smith-Waterman score: 379; 35.1% identity (66.5% similar) in 194 aa overlap (37-230:1-189) 10 20 30 40 50 60 pF1KE2 LLSCVRGPLRPPVRCPAWRPFASGANFEYIIAEKRGKNNTVGLIQLNRPKALNALCDGLI .:: .:...::.: : .::. :. NP_001 MAEYTRLHNALALIRLRNPP-VNAISTTLL 10 20 70 80 90 100 110 120 pF1KE2 DELNQALKTFEEDPAVGAIVLTGGDKAFAAGADIKEMQNLSFQDCYSSKFLKHWDHLTQV .....:. : .. :::. :.. :.:::::. ..: .. . . :.. . NP_001 RDIKEGLQKAVIDHTIKAIVICGAEGKFSAGADIR---GFSAPRTFGLTLGHVVDEIQRN 30 40 50 60 70 80 130 140 150 160 170 180 pF1KE2 KKPVIAAVNGYAFGGGCELAMMCDIIYAGEKAQFAQPEILIGTIPGAGGTQRLTRAVGKS .:::.::..:.::::: :::. : : .:: . ::. .: .::: ::: : : .: NP_001 EKPVVAAIQGMAFGGGLELALGCHYRIAHAEAQVGLPEVTLGLLPGARGTQLLPRLTGVP 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE2 LAMEMVLTGDRISAQDAKQAGLVSKICPVETLVEEAIQCAEKIASNSKIVVAMAKESVNA :.... .: :: :..: . :...:. . :::::. :.... NP_001 AALDLITSGRRILADEALKLGILDKVVNSDP-VEEAIRFAQRVSDQPLESRRLCNKPIQS 150 160 170 180 190 200 250 260 270 280 290 pF1KE2 AFEMTLTEGSKLEKKLFYSTFATDDRKEGMTAFVEKRKANFKDQ NP_001 LPNMDSIFSEALLKMRRQHPGCLAQEACVRAVQAAVQYPYEVGIKKEEELFLYLLQSGQA 210 220 230 240 250 260 >>XP_016870338 (OMIM: 250950,600529) PREDICTED: methylgl (323 aa) initn: 361 init1: 264 opt: 367 Z-score: 463.8 bits: 93.9 E(85289): 4.3e-19 Smith-Waterman score: 392; 31.0% identity (62.7% similar) in 255 aa overlap (43-290:85-323) 20 30 40 50 60 70 pF1KE2 GPLRPPVRCPAWRPFASGANFEYIIAEKRGKNNTVGLIQLNRPKALNALCDGLIDELNQA .: . .. .:: . :.: .:: :..: XP_016 VPAAGGPAPKRGYSSEMKTEDELRVRHLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKA 60 70 80 90 100 110 80 90 100 110 120 pF1KE2 LKTFEEDPAVGAIVLTGG-DKAFAAGADIKEMQNLSFQDC--YSSKFLKHWDHLTQVKKP . ... : : .:.. . : ::::.:: ..: .. . ::. . .... : XP_016 VDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDIANLPVP 120 130 140 150 160 170 130 140 150 160 170 180 pF1KE2 VIAAVNGYAFGGGCELAMMCDIIYAGEKAQFAQPEILIGTIPGAGGTQRLTRAVGKSLAM .:::..: :.::: :::. ::: :. .:... : .. :::.:::::: ::.: ::: XP_016 TIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAK 180 190 200 210 220 230 190 200 210 220 230 240 pF1KE2 EMVLTGDRISAQDAKQAGLVSKICPV----ETLVEEAIQCAEKIASNSKIVVAMAKESVN :..... .....:: .::.:.. .. ..:.. :... .. ... .:: ..: XP_016 ELIFSARVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAIN 240 250 260 270 280 290 250 260 270 280 290 pF1KE2 AAFEMTLTEGSKLEKKLFYSTFATDDRKEGMTAFVEKRKANFKDQ ..: :. : :: ::. :: ::: .: . XP_016 QGME----------------TIPTKDRLEGLLAFKEKRPPRYKGE 300 310 320 >>NP_001293119 (OMIM: 250950,600529) methylglutaconyl-Co (310 aa) initn: 305 init1: 254 opt: 365 Z-score: 461.6 bits: 93.4 E(85289): 5.7e-19 Smith-Waterman score: 365; 36.1% identity (70.5% similar) in 166 aa overlap (129-290:145-310) 100 110 120 130 140 150 pF1KE2 DIKEMQNLSFQDCYSSKFLKHWDHLTQVKKPVIAAVNGYAFGGGCELAMMCDIIYAGEKA :.:::..: :.::: :::. ::: :. .: NP_001 VDALKSDKKVRTIIIRSEVPGIFCAANLPVPTIAAIDGLALGGGLELALACDIRVAASSA 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE2 QFAQPEILIGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKICPV--- ... : .. :::.:::::: ::.: ::: :..... .....:: .::.:.. NP_001 KMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQE 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE2 -ETLVEEAIQCAEKIASNSKIVVAMAKESVNAAFEMTLTEGSKLEKKLFYSTFATDDRKE .. ..:.. :... .. ... .:: ..: ..:. :. : .:. . .:. : :: : NP_001 GDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKDRLE 240 250 260 270 280 290 280 290 pF1KE2 GMTAFVEKRKANFKDQ :. :: ::: .: . NP_001 GLLAFKEKRPPRYKGE 300 310 >>XP_006717213 (OMIM: 250950,600529) PREDICTED: methylgl (320 aa) initn: 305 init1: 254 opt: 365 Z-score: 461.4 bits: 93.5 E(85289): 5.8e-19 Smith-Waterman score: 365; 36.1% identity (70.5% similar) in 166 aa overlap (129-290:155-320) 100 110 120 130 140 150 pF1KE2 DIKEMQNLSFQDCYSSKFLKHWDHLTQVKKPVIAAVNGYAFGGGCELAMMCDIIYAGEKA :.:::..: :.::: :::. ::: :. .: XP_006 VDALKSDKKVRTIIIRSEVPGIFCAANLPVPTIAAIDGLALGGGLELALACDIRVAASSA 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE2 QFAQPEILIGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKICPV--- ... : .. :::.:::::: ::.: ::: :..... .....:: .::.:.. XP_006 KMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQE 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE2 -ETLVEEAIQCAEKIASNSKIVVAMAKESVNAAFEMTLTEGSKLEKKLFYSTFATDDRKE .. ..:.. :... .. ... .:: ..: ..:. :. : .:. . .:. : :: : XP_006 GDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKDRLE 250 260 270 280 290 300 280 290 pF1KE2 GMTAFVEKRKANFKDQ :. :: ::: .: . XP_006 GLLAFKEKRPPRYKGE 310 320 >>XP_005252124 (OMIM: 250950,600529) PREDICTED: methylgl (333 aa) initn: 361 init1: 264 opt: 362 Z-score: 457.4 bits: 92.8 E(85289): 9.8e-19 Smith-Waterman score: 387; 31.3% identity (63.1% similar) in 249 aa overlap (49-290:101-333) 20 30 40 50 60 70 pF1KE2 VRCPAWRPFASGANFEYIIAEKRGKNNTVGLIQLNRPKALNALCDGLIDELNQALKTFEE .. .:: . :.: .:: :..:. ... XP_005 MKTEDELRVRHLEEENRDSSSMAADHYRIVVLGINRAYGKNSLSKNLIKMLSKAVDALKS 80 90 100 110 120 130 80 90 100 110 120 130 pF1KE2 DPAVGAIVLTGG-DKAFAAGADIKEMQNLSFQDC--YSSKFLKHWDHLTQVKKPVIAAVN : : .:.. . : ::::.:: ..: .. . ::. . .... :.:::.. XP_005 DKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDIANLPVPTIAAID 140 150 160 170 180 190 140 150 160 170 180 190 pF1KE2 GYAFGGGCELAMMCDIIYAGEKAQFAQPEILIGTIPGAGGTQRLTRAVGKSLAMEMVLTG : :.::: :::. ::: :. .:... : .. :::.:::::: ::.: ::: :..... XP_005 GLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSA 200 210 220 230 240 250 200 210 220 230 240 250 pF1KE2 DRISAQDAKQAGLVSKICPV----ETLVEEAIQCAEKIASNSKIVVAMAKESVNAAFEMT .....:: .::.:.. .. ..:.. :... .. ... .:: ..: ..: XP_005 RVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGME-- 260 270 280 290 300 260 270 280 290 pF1KE2 LTEGSKLEKKLFYSTFATDDRKEGMTAFVEKRKANFKDQ :. : :: ::. :: ::: .: . XP_005 --------------TIPTKDRLEGLLAFKEKRPPRYKGE 310 320 330 290 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 15:17:27 2016 done: Sun Nov 6 15:17:28 2016 Total Scan time: 6.140 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]