FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE2349, 314 aa
  1>>>pF1KE2349 314 - 314 aa - 314 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.4167+/-0.000264; mu= 7.2583+/- 0.017
 mean_var=124.9598+/-25.326, 0's: 0 Z-trim(122.9): 6  B-trim: 2186 in 1/59
 Lambda= 0.114733
 statistics sampled from 41722 (41728) to 41722 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.79), E-opt: 0.2 (0.489), width:  16
 Scan time:  9.610

The best scores are:                                      opt bits E(85289)
NP_338599 (OMIM: 152700,192315,225750,606609,61044 ( 314) 2114 360.1 3.3e-99
NP_057465 (OMIM: 152700,192315,225750,606609,61044 ( 369) 2114 360.1 3.8e-99
NP_009179 (OMIM: 152700,192315,225750,606609,61044 ( 304) 2039 347.7 1.8e-95
NP_542432 (OMIM: 300370) three prime repair exonuc ( 236)  605 110.3   4e-24


>>NP_338599 (OMIM: 152700,192315,225750,606609,610448) t  (314 aa)
 initn: 2114 init1: 2114 opt: 2114  Z-score: 1902.1  bits: 360.1 E(85289): 3.3e-99
Smith-Waterman score: 2114; 100.0% identity (100.0% similar) in 314 aa overlap (1-314:1-314)

               10        20        30        40        50        60
pF1KE2 MGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_338 MGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 PRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_338 PRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 LVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_338 LVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 SIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_338 SIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASAR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 TKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_338 TKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLA
              250       260       270       280       290       300

              310    
pF1KE2 VATLYGLSLATPGE
       ::::::::::::::
NP_338 VATLYGLSLATPGE
              310    

>>NP_057465 (OMIM: 152700,192315,225750,606609,610448) t  (369 aa)
 initn: 2114 init1: 2114 opt: 2114  Z-score: 1901.0  bits: 360.1 E(85289): 3.8e-99
Smith-Waterman score: 2114; 100.0% identity (100.0% similar) in 314 aa overlap (1-314:56-369)

                                             10        20        30
pF1KE2                               MGSQALPPGPMQTLIFFDMEATGLPFSQPK
                                     ::::::::::::::::::::::::::::::
NP_057 PLPPLRILTLGTHTPTPCSSPGSAAGTYPTMGSQALPPGPMQTLIFFDMEATGLPFSQPK
          30        40        50        60        70        80     

               40        50        60        70        80        90
pF1KE2 VTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVDKLSLCVAPGKACSPAASEITGLSTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 VTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVDKLSLCVAPGKACSPAASEITGLSTA
          90       100       110       120       130       140     

              100       110       120       130       140       150
pF1KE2 VLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 VLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGA
         150       160       170       180       190       200     

              160       170       180       190       200       210
pF1KE2 FCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 FCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQW
         210       220       230       240       250       260     

              220       230       240       250       260       270
pF1KE2 RPQALLRWVDAHARPFGTIRPMYGVTASARTKPRPSAVTTTAHLATTRNTSPSLGESRGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 RPQALLRWVDAHARPFGTIRPMYGVTASARTKPRPSAVTTTAHLATTRNTSPSLGESRGT
         270       280       290       300       310       320     

              280       290       300       310    
pF1KE2 KDLPPVKDPGALSREGLLAPLGLLAILTLAVATLYGLSLATPGE
       ::::::::::::::::::::::::::::::::::::::::::::
NP_057 KDLPPVKDPGALSREGLLAPLGLLAILTLAVATLYGLSLATPGE
         330       340       350       360         

>>NP_009179 (OMIM: 152700,192315,225750,606609,610448) t  (304 aa)
 initn: 2039 init1: 2039 opt: 2039  Z-score: 1835.2  bits: 347.7 E(85289): 1.8e-95
Smith-Waterman score: 2039; 100.0% identity (100.0% similar) in 304 aa overlap (11-314:1-304)

               10        20        30        40        50        60
pF1KE2 MGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPP
                 ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009           MQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPP
                         10        20        30        40        50

               70        80        90       100       110       120
pF1KE2 PRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 PRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWC
               60        70        80        90       100       110

              130       140       150       160       170       180
pF1KE2 LVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLG
              120       130       140       150       160       170

              190       200       210       220       230       240
pF1KE2 SIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 SIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASAR
              180       190       200       210       220       230

              250       260       270       280       290       300
pF1KE2 TKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 TKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLA
              240       250       260       270       280       290

              310    
pF1KE2 VATLYGLSLATPGE
       ::::::::::::::
NP_009 VATLYGLSLATPGE
              300    

>>NP_542432 (OMIM: 300370) three prime repair exonucleas  (236 aa)
 initn: 412 init1: 412 opt: 605  Z-score: 554.0  bits: 110.3 E(85289): 4e-24
Smith-Waterman score: 605; 46.5% identity (66.8% similar) in 226 aa overlap (12-233:8-226)

               10        20        30        40        50        60
pF1KE2 MGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPP
                  .:..:.:.::::::  .:...:: :.:::: .::.:  ...   ..:  
NP_542     MSEAPRAETFVFLDLEATGLPSVEPEIAELSLFAVHRSSLENPEHDESGALVLP--
                   10        20        30        40        50      

               70        80        90       100       110       120
pF1KE2 PRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWC
        ::.:::.::. : .  .  ::::::::.  ::   .  ::  ..  : ::: ::  : :
NP_542 -RVLDKLTLCMCPERPFTAKASEITGLSSEGLARCRKAGFDGAVVRTLQAFLSRQAGPIC
            60        70        80        90       100       110   

              130       140       150       160       170          
pF1KE2 LVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPR----KS
       ::::::  :::::: :::  ::     : . :.:.. ::..:.:: :   :: :    ..
NP_542 LVAHNGFDYDFPLLCAELRRLGARLPRD-TVCLDTLPALRGLDRAHS---HGTRARGRQG
           120       130       140        150          160         

        180       190       200       210       220       230      
pF1KE2 YSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVT
       :::::.. : .   :  .:.::::: .:: :   :   :: :.: .:: .. :.:::   
NP_542 YSLGSLFHRYFRAEPSAAHSAEGDVHTLLLIFLHRAAELLAWADEQARGWAHIEPMYLPP
     170       180       190       200       210       220         

        240       250       260       270       280       290      
pF1KE2 ASARTKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAI
                                                                   
NP_542 DDPSLEA                                                     
     230                                                           




314 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 17:48:54 2016 done: Sun Nov  6 17:48:56 2016
 Total Scan time:  9.610 Total Display time:  0.000

Function used was FASTA [36.3.4 Apr, 2011]