Result of FASTA (omim) for
pF1KE2354
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2354, 3224 aa
1>>>pF1KE2354 3224 - 3224 aa - 3224 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.9336+/-0.000568; mu= 9.1787+/- 0.035
mean_var=196.9366+/-42.085, 0's: 0 Z-trim(113.0): 212 B-trim: 784 in 3/53
Lambda= 0.091393
statistics sampled from 21853 (22082) to 21853 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.586), E-opt: 0.2 (0.259), width: 16
Scan time: 27.750
The best scores are: opt bits E(85289)
NP_006258 (OMIM: 601181,608033) E3 SUMO-protein li (3224) 21603 2863.8 0
XP_005264061 (OMIM: 601181,608033) PREDICTED: E3 S (3232) 21577 2860.3 0
XP_016860112 (OMIM: 601181,608033) PREDICTED: E3 S (2807) 17566 2331.4 0
XP_005264060 (OMIM: 601181,608033) PREDICTED: E3 S (3250) 17566 2331.5 0
XP_005264059 (OMIM: 601181,608033) PREDICTED: E3 S (3258) 17566 2331.5 0
XP_011509877 (OMIM: 601181,608033) PREDICTED: E3 S (3257) 17548 2329.1 0
XP_005264062 (OMIM: 601181,608033) PREDICTED: E3 S (3232) 17400 2309.6 0
XP_011509878 (OMIM: 601181,608033) PREDICTED: E3 S (3199) 11802 1571.5 0
XP_005264064 (OMIM: 601181,608033) PREDICTED: E3 S (2282) 5996 805.9 0
XP_011509880 (OMIM: 601181,608033) PREDICTED: E3 S (2281) 5978 803.5 0
XP_016860113 (OMIM: 601181,608033) PREDICTED: E3 S ( 874) 5792 778.7 0
XP_016860114 (OMIM: 601181,608033) PREDICTED: E3 S ( 904) 5784 777.7 0
XP_016860315 (OMIM: 602752) PREDICTED: RANBP2-like ( 904) 5515 742.2 9.4e-213
NP_115636 (OMIM: 612708) RANBP2-like and GRIP doma ( 904) 5506 741.0 2.1e-212
NP_001032955 (OMIM: 612709) RANBP2-like and GRIP d ( 904) 5506 741.0 2.1e-212
XP_016860229 (OMIM: 612706) PREDICTED: ranBP2-like ( 905) 5505 740.9 2.3e-212
XP_016859387 (OMIM: 612707) PREDICTED: ranBP2-like ( 905) 5501 740.3 3.4e-212
XP_011531153 (OMIM: 612704) PREDICTED: RANBP2-like (1698) 4743 640.6 6.9e-182
XP_016860338 (OMIM: 612705) PREDICTED: RANBP2-like (1814) 4734 639.4 1.7e-181
XP_011509321 (OMIM: 612707) PREDICTED: ranBP2-like (1661) 4730 638.8 2.2e-181
XP_016860228 (OMIM: 612706) PREDICTED: ranBP2-like (1669) 4717 637.1 7.3e-181
XP_011510072 (OMIM: 612709) PREDICTED: RANBP2-like (1689) 4711 636.3 1.3e-180
XP_005263804 (OMIM: 602752) PREDICTED: RANBP2-like (1660) 4693 634.0 6.5e-180
XP_011531154 (OMIM: 612704) PREDICTED: RANBP2-like (1697) 4666 630.4 7.9e-179
XP_011531151 (OMIM: 612704) PREDICTED: RANBP2-like (1724) 4665 630.3 8.7e-179
XP_016860339 (OMIM: 612705) PREDICTED: RANBP2-like (1813) 4657 629.2 1.9e-178
XP_011531152 (OMIM: 612704) PREDICTED: RANBP2-like (1712) 4656 629.1 2e-178
XP_016859596 (OMIM: 612704) PREDICTED: RANBP2-like (1740) 4656 629.1 2e-178
NP_001019628 (OMIM: 612704) RANBP2-like and GRIP d (1748) 4656 629.1 2e-178
XP_016859594 (OMIM: 612704) PREDICTED: RANBP2-like (1760) 4656 629.1 2e-178
XP_016859595 (OMIM: 612704) PREDICTED: RANBP2-like (1760) 4656 629.1 2e-178
XP_016859593 (OMIM: 612704) PREDICTED: RANBP2-like (1780) 4656 629.1 2e-178
XP_011531147 (OMIM: 612704) PREDICTED: RANBP2-like (1801) 4656 629.1 2.1e-178
XP_016859592 (OMIM: 612704) PREDICTED: RANBP2-like (1805) 4656 629.1 2.1e-178
XP_011509322 (OMIM: 612707) PREDICTED: ranBP2-like (1660) 4653 628.7 2.5e-178
XP_011509320 (OMIM: 612707) PREDICTED: ranBP2-like (1687) 4652 628.6 2.8e-178
NP_001071638 (OMIM: 612705) RANBP2-like and GRIP d (1756) 4647 627.9 4.6e-178
XP_016860336 (OMIM: 612705) PREDICTED: RANBP2-like (1759) 4647 627.9 4.6e-178
XP_016860335 (OMIM: 612705) PREDICTED: RANBP2-like (1760) 4647 627.9 4.6e-178
XP_016860337 (OMIM: 612705) PREDICTED: RANBP2-like (1828) 4647 627.9 4.7e-178
XP_016860334 (OMIM: 612705) PREDICTED: RANBP2-like (1917) 4647 627.9 4.9e-178
XP_011509319 (OMIM: 612707) PREDICTED: ranBP2-like (1703) 4643 627.4 6.4e-178
NP_872394 (OMIM: 612707) ranBP2-like and GRIP doma (1758) 4643 627.4 6.6e-178
XP_011510071 (OMIM: 612709) PREDICTED: RANBP2-like (1715) 4633 626.1 1.6e-177
NP_001137485 (OMIM: 612706) ranBP2-like and GRIP d (1758) 4630 625.7 2.2e-177
XP_016860227 (OMIM: 612706) PREDICTED: ranBP2-like (1766) 4630 625.7 2.2e-177
XP_016860333 (OMIM: 612709) PREDICTED: RANBP2-like (1480) 4624 624.8 3.3e-177
XP_016860571 (OMIM: 612708) PREDICTED: RANBP2-like (1480) 4624 624.8 3.3e-177
XP_016860570 (OMIM: 612708) PREDICTED: RANBP2-like (1700) 4624 624.9 3.7e-177
XP_016860332 (OMIM: 612709) PREDICTED: RANBP2-like (1703) 4624 624.9 3.7e-177
>>NP_006258 (OMIM: 601181,608033) E3 SUMO-protein ligase (3224 aa)
initn: 21603 init1: 21603 opt: 21603 Z-score: 15396.5 bits: 2863.8 E(85289): 0
Smith-Waterman score: 21603; 100.0% identity (100.0% similar) in 3224 aa overlap (1-3224:1-3224)
10 20 30 40 50 60
pF1KE2 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE2 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE2 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KE2 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KE2 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KE2 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKAKEKKKPEDSPSDDDVLIVYELTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKAKEKKKPEDSPSDDDVLIVYELTP
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KE2 TAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDDEDFETAVKKLNGKLYLDGSEKCRPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDDEDFETAVKKLNGKLYLDGSEKCRPLE
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740 2750 2760
pF1KE2 ENTADNEKECIIVWEKKPTVEEKAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELQKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ENTADNEKECIIVWEKKPTVEEKAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELQKV
2710 2720 2730 2740 2750 2760
2770 2780 2790 2800 2810 2820
pF1KE2 QEAQKSQTEEITSTTDSVYTGGTEVMVPSFCKSEEPDSITKSISSPSVSSETMDKPVDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QEAQKSQTEEITSTTDSVYTGGTEVMVPSFCKSEEPDSITKSISSPSVSSETMDKPVDLS
2770 2780 2790 2800 2810 2820
2830 2840 2850 2860 2870 2880
pF1KE2 TRKEIDTDSTSQGESKIVSFGFGSSTGLSFADLASSNSGDFAFGSKDKNFQWANTGAAVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TRKEIDTDSTSQGESKIVSFGFGSSTGLSFADLASSNSGDFAFGSKDKNFQWANTGAAVF
2830 2840 2850 2860 2870 2880
2890 2900 2910 2920 2930 2940
pF1KE2 GTQSVGTQSAGKVGEDEDGSDEEVVHNEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GTQSVGTQSAGKVGEDEDGSDEEVVHNEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKL
2890 2900 2910 2920 2930 2940
2950 2960 2970 2980 2990 3000
pF1KE2 YRWDRDVSQWKERGVGDIKILWHTMKNYYRILMRRDQVFKVCANHVITKTMELKPLNVSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 YRWDRDVSQWKERGVGDIKILWHTMKNYYRILMRRDQVFKVCANHVITKTMELKPLNVSN
2950 2960 2970 2980 2990 3000
3010 3020 3030 3040 3050 3060
pF1KE2 NALVWTASDYADGEAKVEQLAVRFKTKEVADCFKKTFEECQQNLMKLQKGHVSLAAELSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NALVWTASDYADGEAKVEQLAVRFKTKEVADCFKKTFEECQQNLMKLQKGHVSLAAELSK
3010 3020 3030 3040 3050 3060
3070 3080 3090 3100 3110 3120
pF1KE2 ETNPVVFFDVCADGEPLGRITMELFSNIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ETNPVVFFDVCADGEPLGRITMELFSNIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDF
3070 3080 3090 3100 3110 3120
3130 3140 3150 3160 3170 3180
pF1KE2 VCQGGDITKHDGTGGQSIYGDKFEDENFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VCQGGDITKHDGTGGQSIYGDKFEDENFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAE
3130 3140 3150 3160 3170 3180
3190 3200 3210 3220
pF1KE2 HLDFKHVVFGFVKDGMDTVKKIESFGSPKGSVCRRITITECGQI
::::::::::::::::::::::::::::::::::::::::::::
NP_006 HLDFKHVVFGFVKDGMDTVKKIESFGSPKGSVCRRITITECGQI
3190 3200 3210 3220
>>XP_005264061 (OMIM: 601181,608033) PREDICTED: E3 SUMO- (3232 aa)
initn: 18559 init1: 18559 opt: 21577 Z-score: 15378.0 bits: 2860.3 E(85289): 0
Smith-Waterman score: 21577; 99.8% identity (99.8% similar) in 3232 aa overlap (1-3224:1-3232)
10 20 30 40 50 60
pF1KE2 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE2 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE2 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KE2 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KE2 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KE2 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKAKEKKKPEDSPSDDDVLIVYELTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKAKEKKKPEDSPSDDDVLIVYELTP
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KE2 TAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDDEDFETAVKKLNGKLYLDGSEKCRPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDDEDFETAVKKLNGKLYLDGSEKCRPLE
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740 2750 2760
pF1KE2 ENTADNEKECIIVWEKKPTVEEKAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELQKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENTADNEKECIIVWEKKPTVEEKAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELQKV
2710 2720 2730 2740 2750 2760
2770 2780 2790 2800 2810
pF1KE2 QEAQ--------KSQTEEITSTTDSVYTGGTEVMVPSFCKSEEPDSITKSISSPSVSSET
:::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QEAQYFVTSSLQKSQTEEITSTTDSVYTGGTEVMVPSFCKSEEPDSITKSISSPSVSSET
2770 2780 2790 2800 2810 2820
2820 2830 2840 2850 2860 2870
pF1KE2 MDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSSTGLSFADLASSNSGDFAFGSKDKNFQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSSTGLSFADLASSNSGDFAFGSKDKNFQW
2830 2840 2850 2860 2870 2880
2880 2890 2900 2910 2920 2930
pF1KE2 ANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVHNEDIHFEPIVSLPEVEVKSGEEDEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVHNEDIHFEPIVSLPEVEVKSGEEDEEI
2890 2900 2910 2920 2930 2940
2940 2950 2960 2970 2980 2990
pF1KE2 LFKERAKLYRWDRDVSQWKERGVGDIKILWHTMKNYYRILMRRDQVFKVCANHVITKTME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFKERAKLYRWDRDVSQWKERGVGDIKILWHTMKNYYRILMRRDQVFKVCANHVITKTME
2950 2960 2970 2980 2990 3000
3000 3010 3020 3030 3040 3050
pF1KE2 LKPLNVSNNALVWTASDYADGEAKVEQLAVRFKTKEVADCFKKTFEECQQNLMKLQKGHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKPLNVSNNALVWTASDYADGEAKVEQLAVRFKTKEVADCFKKTFEECQQNLMKLQKGHV
3010 3020 3030 3040 3050 3060
3060 3070 3080 3090 3100 3110
pF1KE2 SLAAELSKETNPVVFFDVCADGEPLGRITMELFSNIVPRTAENFRALCTGEKGFGFKNSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLAAELSKETNPVVFFDVCADGEPLGRITMELFSNIVPRTAENFRALCTGEKGFGFKNSI
3070 3080 3090 3100 3110 3120
3120 3130 3140 3150 3160 3170
pF1KE2 FHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDENFDVKHTGPGLLSMANQGQNTNNSQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDENFDVKHTGPGLLSMANQGQNTNNSQF
3130 3140 3150 3160 3170 3180
3180 3190 3200 3210 3220
pF1KE2 VITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFGSPKGSVCRRITITECGQI
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFGSPKGSVCRRITITECGQI
3190 3200 3210 3220 3230
>>XP_016860112 (OMIM: 601181,608033) PREDICTED: E3 SUMO- (2807 aa)
initn: 18559 init1: 17557 opt: 17566 Z-score: 12520.7 bits: 2331.4 E(85289): 0
Smith-Waterman score: 18497; 98.8% identity (99.0% similar) in 2797 aa overlap (1-2771:1-2797)
10 20 30 40 50 60
pF1KE2 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE2 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE2 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KE2 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KE2 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
2530 2540 2550 2560 2570 2580
2590 2600 2610
pF1KE2 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEK------------------------
::::::::::::::::::::::::::::::::::::
XP_016 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKGFNFSLFKSNPMAFWTSTPSSQPE
2590 2600 2610 2620 2630 2640
2620 2630 2640 2650 2660 2670
pF1KE2 --AKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKAKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
2650 2660 2670 2680 2690 2700
2680 2690 2700 2710 2720 2730
pF1KE2 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
2710 2720 2730 2740 2750 2760
2740 2750 2760 2770 2780 2790
pF1KE2 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQKSQTEEITSTTDSVYTGGTEVMVPSFCKSE
::::::::::::::::::::::::::::::... ...
XP_016 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQQKRRKNLKILPQIVSVS
2770 2780 2790 2800
2800 2810 2820 2830 2840 2850
pF1KE2 EPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSSTGLSFADLA
>>XP_005264060 (OMIM: 601181,608033) PREDICTED: E3 SUMO- (3250 aa)
initn: 17557 init1: 17557 opt: 17566 Z-score: 12519.8 bits: 2331.5 E(85289): 0
Smith-Waterman score: 21541; 99.2% identity (99.2% similar) in 3250 aa overlap (1-3224:1-3250)
10 20 30 40 50 60
pF1KE2 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE2 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE2 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KE2 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KE2 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
2530 2540 2550 2560 2570 2580
2590 2600 2610
pF1KE2 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEK------------------------
::::::::::::::::::::::::::::::::::::
XP_005 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKGFNFSLFKSNPMAFWTSTPSSQPE
2590 2600 2610 2620 2630 2640
2620 2630 2640 2650 2660 2670
pF1KE2 --AKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKAKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
2650 2660 2670 2680 2690 2700
2680 2690 2700 2710 2720 2730
pF1KE2 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
2710 2720 2730 2740 2750 2760
2740 2750 2760 2770 2780 2790
pF1KE2 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQKSQTEEITSTTDSVYTGGTEVMVPSFCKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQKSQTEEITSTTDSVYTGGTEVMVPSFCKSE
2770 2780 2790 2800 2810 2820
2800 2810 2820 2830 2840 2850
pF1KE2 EPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSSTGLSFADLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSSTGLSFADLA
2830 2840 2850 2860 2870 2880
2860 2870 2880 2890 2900 2910
pF1KE2 SSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVHNEDIHFEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVHNEDIHFEP
2890 2900 2910 2920 2930 2940
2920 2930 2940 2950 2960 2970
pF1KE2 IVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMKNYYRILMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMKNYYRILMR
2950 2960 2970 2980 2990 3000
2980 2990 3000 3010 3020 3030
pF1KE2 RDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKTKEVADCFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKTKEVADCFK
3010 3020 3030 3040 3050 3060
3040 3050 3060 3070 3080 3090
pF1KE2 KTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFSNIVPRTAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFSNIVPRTAE
3070 3080 3090 3100 3110 3120
3100 3110 3120 3130 3140 3150
pF1KE2 NFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDENFDVKHTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDENFDVKHTG
3130 3140 3150 3160 3170 3180
3160 3170 3180 3190 3200 3210
pF1KE2 PGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFGSPKGSVCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFGSPKGSVCR
3190 3200 3210 3220 3230 3240
3220
pF1KE2 RITITECGQI
::::::::::
XP_005 RITITECGQI
3250
>>XP_005264059 (OMIM: 601181,608033) PREDICTED: E3 SUMO- (3258 aa)
initn: 20599 init1: 17557 opt: 17566 Z-score: 12519.8 bits: 2331.5 E(85289): 0
Smith-Waterman score: 21503; 99.0% identity (99.0% similar) in 3256 aa overlap (1-3222:1-3256)
10 20 30 40 50 60
pF1KE2 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE2 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE2 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KE2 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KE2 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
2530 2540 2550 2560 2570 2580
2590 2600 2610
pF1KE2 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEK------------------------
::::::::::::::::::::::::::::::::::::
XP_005 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKGFNFSLFKSNPMAFWTSTPSSQPE
2590 2600 2610 2620 2630 2640
2620 2630 2640 2650 2660 2670
pF1KE2 --AKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKAKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
2650 2660 2670 2680 2690 2700
2680 2690 2700 2710 2720 2730
pF1KE2 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
2710 2720 2730 2740 2750 2760
2740 2750 2760 2770 2780
pF1KE2 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQ--------KSQTEEITSTTDSVYTGGTEVM
:::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_005 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQYFVTSSLQKSQTEEITSTTDSVYTGGTEVM
2770 2780 2790 2800 2810 2820
2790 2800 2810 2820 2830 2840
pF1KE2 VPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSST
2830 2840 2850 2860 2870 2880
2850 2860 2870 2880 2890 2900
pF1KE2 GLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVH
2890 2900 2910 2920 2930 2940
2910 2920 2930 2940 2950 2960
pF1KE2 NEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMK
2950 2960 2970 2980 2990 3000
2970 2980 2990 3000 3010 3020
pF1KE2 NYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKT
3010 3020 3030 3040 3050 3060
3030 3040 3050 3060 3070 3080
pF1KE2 KEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFS
3070 3080 3090 3100 3110 3120
3090 3100 3110 3120 3130 3140
pF1KE2 NIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDE
3130 3140 3150 3160 3170 3180
3150 3160 3170 3180 3190 3200
pF1KE2 NFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFG
3190 3200 3210 3220 3230 3240
3210 3220
pF1KE2 SPKGSVCRRITITECGQI
::::::::::::::::
XP_005 SPKGSVCRRITITECGQI
3250
>>XP_011509877 (OMIM: 601181,608033) PREDICTED: E3 SUMO- (3257 aa)
initn: 20441 init1: 17399 opt: 17548 Z-score: 12506.9 bits: 2329.1 E(85289): 0
Smith-Waterman score: 21485; 98.9% identity (98.9% similar) in 3256 aa overlap (1-3222:1-3255)
10 20 30 40 50 60
pF1KE2 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
:::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::
XP_011 MRRSKADVERYIASVQGSTPSPRQ-SMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE2 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE2 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE2 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE2 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE2 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
780 790 800 810 820 830
850 860 870 880 890 900
pF1KE2 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
840 850 860 870 880 890
910 920 930 940 950 960
pF1KE2 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KE2 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KE2 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KE2 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KE2 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KE2 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KE2 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KE2 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KE2 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480 1490 1500
pF1KE2 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
1440 1450 1460 1470 1480 1490
1510 1520 1530 1540 1550 1560
pF1KE2 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
1500 1510 1520 1530 1540 1550
1570 1580 1590 1600 1610 1620
pF1KE2 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
1560 1570 1580 1590 1600 1610
1630 1640 1650 1660 1670 1680
pF1KE2 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
1620 1630 1640 1650 1660 1670
1690 1700 1710 1720 1730 1740
pF1KE2 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
1680 1690 1700 1710 1720 1730
1750 1760 1770 1780 1790 1800
pF1KE2 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
1740 1750 1760 1770 1780 1790
1810 1820 1830 1840 1850 1860
pF1KE2 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
1800 1810 1820 1830 1840 1850
1870 1880 1890 1900 1910 1920
pF1KE2 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
1860 1870 1880 1890 1900 1910
1930 1940 1950 1960 1970 1980
pF1KE2 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
1920 1930 1940 1950 1960 1970
1990 2000 2010 2020 2030 2040
pF1KE2 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
1980 1990 2000 2010 2020 2030
2050 2060 2070 2080 2090 2100
pF1KE2 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
2040 2050 2060 2070 2080 2090
2110 2120 2130 2140 2150 2160
pF1KE2 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
2100 2110 2120 2130 2140 2150
2170 2180 2190 2200 2210 2220
pF1KE2 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
2160 2170 2180 2190 2200 2210
2230 2240 2250 2260 2270 2280
pF1KE2 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
2220 2230 2240 2250 2260 2270
2290 2300 2310 2320 2330 2340
pF1KE2 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
2280 2290 2300 2310 2320 2330
2350 2360 2370 2380 2390 2400
pF1KE2 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
2340 2350 2360 2370 2380 2390
2410 2420 2430 2440 2450 2460
pF1KE2 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
2400 2410 2420 2430 2440 2450
2470 2480 2490 2500 2510 2520
pF1KE2 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
2460 2470 2480 2490 2500 2510
2530 2540 2550 2560 2570 2580
pF1KE2 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
2520 2530 2540 2550 2560 2570
2590 2600 2610
pF1KE2 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEK------------------------
::::::::::::::::::::::::::::::::::::
XP_011 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKGFNFSLFKSNPMAFWTSTPSSQPE
2580 2590 2600 2610 2620 2630
2620 2630 2640 2650 2660 2670
pF1KE2 --AKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKAKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
2640 2650 2660 2670 2680 2690
2680 2690 2700 2710 2720 2730
pF1KE2 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
2700 2710 2720 2730 2740 2750
2740 2750 2760 2770 2780
pF1KE2 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQ--------KSQTEEITSTTDSVYTGGTEVM
:::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_011 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQYFVTSSLQKSQTEEITSTTDSVYTGGTEVM
2760 2770 2780 2790 2800 2810
2790 2800 2810 2820 2830 2840
pF1KE2 VPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSST
2820 2830 2840 2850 2860 2870
2850 2860 2870 2880 2890 2900
pF1KE2 GLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVH
2880 2890 2900 2910 2920 2930
2910 2920 2930 2940 2950 2960
pF1KE2 NEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMK
2940 2950 2960 2970 2980 2990
2970 2980 2990 3000 3010 3020
pF1KE2 NYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKT
3000 3010 3020 3030 3040 3050
3030 3040 3050 3060 3070 3080
pF1KE2 KEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFS
3060 3070 3080 3090 3100 3110
3090 3100 3110 3120 3130 3140
pF1KE2 NIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDE
3120 3130 3140 3150 3160 3170
3150 3160 3170 3180 3190 3200
pF1KE2 NFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFG
3180 3190 3200 3210 3220 3230
3210 3220
pF1KE2 SPKGSVCRRITITECGQI
::::::::::::::::
XP_011 SPKGSVCRRITITECGQI
3240 3250
>>XP_005264062 (OMIM: 601181,608033) PREDICTED: E3 SUMO- (3232 aa)
initn: 20433 init1: 17391 opt: 17400 Z-score: 12401.5 bits: 2309.6 E(85289): 0
Smith-Waterman score: 21337; 98.9% identity (98.9% similar) in 3230 aa overlap (27-3222:1-3230)
10 20 30 40 50 60
pF1KE2 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
::::::::::::::::::::::::::::::::::
XP_005 MKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
10 20 30
70 80 90 100 110 120
pF1KE2 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE2 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE2 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE2 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE2 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
700 710 720 730 740 750
790 800 810 820 830 840
pF1KE2 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
760 770 780 790 800 810
850 860 870 880 890 900
pF1KE2 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
820 830 840 850 860 870
910 920 930 940 950 960
pF1KE2 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KE2 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KE2 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KE2 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KE2 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
1120 1130 1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KE2 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
1180 1190 1200 1210 1220 1230
1270 1280 1290 1300 1310 1320
pF1KE2 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
1240 1250 1260 1270 1280 1290
1330 1340 1350 1360 1370 1380
pF1KE2 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
1300 1310 1320 1330 1340 1350
1390 1400 1410 1420 1430 1440
pF1KE2 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
1360 1370 1380 1390 1400 1410
1450 1460 1470 1480 1490 1500
pF1KE2 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
1420 1430 1440 1450 1460 1470
1510 1520 1530 1540 1550 1560
pF1KE2 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
1480 1490 1500 1510 1520 1530
1570 1580 1590 1600 1610 1620
pF1KE2 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
1540 1550 1560 1570 1580 1590
1630 1640 1650 1660 1670 1680
pF1KE2 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
1600 1610 1620 1630 1640 1650
1690 1700 1710 1720 1730 1740
pF1KE2 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
1660 1670 1680 1690 1700 1710
1750 1760 1770 1780 1790 1800
pF1KE2 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
1720 1730 1740 1750 1760 1770
1810 1820 1830 1840 1850 1860
pF1KE2 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
1780 1790 1800 1810 1820 1830
1870 1880 1890 1900 1910 1920
pF1KE2 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
1840 1850 1860 1870 1880 1890
1930 1940 1950 1960 1970 1980
pF1KE2 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
1900 1910 1920 1930 1940 1950
1990 2000 2010 2020 2030 2040
pF1KE2 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
1960 1970 1980 1990 2000 2010
2050 2060 2070 2080 2090 2100
pF1KE2 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
2020 2030 2040 2050 2060 2070
2110 2120 2130 2140 2150 2160
pF1KE2 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
2080 2090 2100 2110 2120 2130
2170 2180 2190 2200 2210 2220
pF1KE2 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
2140 2150 2160 2170 2180 2190
2230 2240 2250 2260 2270 2280
pF1KE2 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
2200 2210 2220 2230 2240 2250
2290 2300 2310 2320 2330 2340
pF1KE2 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
2260 2270 2280 2290 2300 2310
2350 2360 2370 2380 2390 2400
pF1KE2 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
2320 2330 2340 2350 2360 2370
2410 2420 2430 2440 2450 2460
pF1KE2 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
2380 2390 2400 2410 2420 2430
2470 2480 2490 2500 2510 2520
pF1KE2 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
2440 2450 2460 2470 2480 2490
2530 2540 2550 2560 2570 2580
pF1KE2 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
2500 2510 2520 2530 2540 2550
2590 2600 2610
pF1KE2 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEK------------------------
::::::::::::::::::::::::::::::::::::
XP_005 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKGFNFSLFKSNPMAFWTSTPSSQPE
2560 2570 2580 2590 2600 2610
2620 2630 2640 2650 2660 2670
pF1KE2 --AKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKAKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
2620 2630 2640 2650 2660 2670
2680 2690 2700 2710 2720 2730
pF1KE2 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
2680 2690 2700 2710 2720 2730
2740 2750 2760 2770 2780
pF1KE2 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQ--------KSQTEEITSTTDSVYTGGTEVM
:::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_005 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQYFVTSSLQKSQTEEITSTTDSVYTGGTEVM
2740 2750 2760 2770 2780 2790
2790 2800 2810 2820 2830 2840
pF1KE2 VPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSST
2800 2810 2820 2830 2840 2850
2850 2860 2870 2880 2890 2900
pF1KE2 GLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVH
2860 2870 2880 2890 2900 2910
2910 2920 2930 2940 2950 2960
pF1KE2 NEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMK
2920 2930 2940 2950 2960 2970
2970 2980 2990 3000 3010 3020
pF1KE2 NYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKT
2980 2990 3000 3010 3020 3030
3030 3040 3050 3060 3070 3080
pF1KE2 KEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFS
3040 3050 3060 3070 3080 3090
3090 3100 3110 3120 3130 3140
pF1KE2 NIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDE
3100 3110 3120 3130 3140 3150
3150 3160 3170 3180 3190 3200
pF1KE2 NFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFG
3160 3170 3180 3190 3200 3210
3210 3220
pF1KE2 SPKGSVCRRITITECGQI
::::::::::::::::
XP_005 SPKGSVCRRITITECGQI
3220 3230
>>XP_011509878 (OMIM: 601181,608033) PREDICTED: E3 SUMO- (3199 aa)
initn: 14544 init1: 11502 opt: 11802 Z-score: 8412.5 bits: 1571.5 E(85289): 0
Smith-Waterman score: 20986; 97.1% identity (97.1% similar) in 3258 aa overlap (1-3224:1-3199)
10 20 30 40 50 60
pF1KE2 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
:::::::::::::::::::::::::::::::::
XP_011 ASATKCIACQNPGKQNQTTSAVSTPASSETSKA---------------------------
1630 1640 1650
1690 1700 1710 1720 1730 1740
pF1KE2 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
::::::::::::::::::::::::::::
XP_011 --------------------------------PKSGFEGMFTKKEGQWDCSVCLVRNEAS
1660 1670 1680
1750 1760 1770 1780 1790 1800
pF1KE2 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
1690 1700 1710 1720 1730 1740
1810 1820 1830 1840 1850 1860
pF1KE2 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
1750 1760 1770 1780 1790 1800
1870 1880 1890 1900 1910 1920
pF1KE2 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
1810 1820 1830 1840 1850 1860
1930 1940 1950 1960 1970 1980
pF1KE2 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
1870 1880 1890 1900 1910 1920
1990 2000 2010 2020 2030 2040
pF1KE2 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
1930 1940 1950 1960 1970 1980
2050 2060 2070 2080 2090 2100
pF1KE2 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
1990 2000 2010 2020 2030 2040
2110 2120 2130 2140 2150 2160
pF1KE2 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
2050 2060 2070 2080 2090 2100
2170 2180 2190 2200 2210 2220
pF1KE2 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
2110 2120 2130 2140 2150 2160
2230 2240 2250 2260 2270 2280
pF1KE2 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
2170 2180 2190 2200 2210 2220
2290 2300 2310 2320 2330 2340
pF1KE2 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
2230 2240 2250 2260 2270 2280
2350 2360 2370 2380 2390 2400
pF1KE2 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
2290 2300 2310 2320 2330 2340
2410 2420 2430 2440 2450 2460
pF1KE2 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
2350 2360 2370 2380 2390 2400
2470 2480 2490 2500 2510 2520
pF1KE2 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
2410 2420 2430 2440 2450 2460
2530 2540 2550 2560 2570 2580
pF1KE2 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
2470 2480 2490 2500 2510 2520
2590 2600 2610
pF1KE2 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEK------------------------
::::::::::::::::::::::::::::::::::::
XP_011 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKGFNFSLFKSNPMAFWTSTPSSQPE
2530 2540 2550 2560 2570 2580
2620 2630 2640 2650 2660 2670
pF1KE2 --AKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKAKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
2590 2600 2610 2620 2630 2640
2680 2690 2700 2710 2720 2730
pF1KE2 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
2650 2660 2670 2680 2690 2700
2740 2750 2760 2770 2780
pF1KE2 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQ--------KSQTEEITSTTDSVYTGGTEVM
:::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_011 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQYFVTSSLQKSQTEEITSTTDSVYTGGTEVM
2710 2720 2730 2740 2750 2760
2790 2800 2810 2820 2830 2840
pF1KE2 VPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSST
2770 2780 2790 2800 2810 2820
2850 2860 2870 2880 2890 2900
pF1KE2 GLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVH
2830 2840 2850 2860 2870 2880
2910 2920 2930 2940 2950 2960
pF1KE2 NEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMK
2890 2900 2910 2920 2930 2940
2970 2980 2990 3000 3010 3020
pF1KE2 NYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKT
2950 2960 2970 2980 2990 3000
3030 3040 3050 3060 3070 3080
pF1KE2 KEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFS
3010 3020 3030 3040 3050 3060
3090 3100 3110 3120 3130 3140
pF1KE2 NIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDE
3070 3080 3090 3100 3110 3120
3150 3160 3170 3180 3190 3200
pF1KE2 NFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFG
3130 3140 3150 3160 3170 3180
3210 3220
pF1KE2 SPKGSVCRRITITECGQI
::::::::::::::::::
XP_011 SPKGSVCRRITITECGQI
3190
>>XP_005264064 (OMIM: 601181,608033) PREDICTED: E3 SUMO- (2282 aa)
initn: 9604 init1: 5996 opt: 5996 Z-score: 4277.4 bits: 805.9 E(85289): 0
Smith-Waterman score: 12818; 69.0% identity (69.0% similar) in 3258 aa overlap (1-3224:1-2282)
10 20 30 40 50 60
pF1KE2 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
XP_005 ------------------------------------------------------------
970 980 990 1000 1010 1020
pF1KE2 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
XP_005 ------------------------------------------------------------
1030 1040 1050 1060 1070 1080
pF1KE2 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
XP_005 ------------------------------------------------------------
1090 1100 1110 1120 1130 1140
pF1KE2 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
XP_005 ------------------------------------------------------------
1150 1160 1170 1180 1190 1200
pF1KE2 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
XP_005 ------------------------------------------------------------
1210 1220 1230 1240 1250 1260
pF1KE2 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
XP_005 ------------------------------------------------------------
1270 1280 1290 1300 1310 1320
pF1KE2 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
XP_005 ------------------------------------------------------------
1330 1340 1350 1360 1370 1380
pF1KE2 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
XP_005 ------------------------------------------------------------
1390 1400 1410 1420 1430 1440
pF1KE2 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
XP_005 ------------------------------------------------------------
1450 1460 1470 1480 1490 1500
pF1KE2 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
XP_005 ------------------------------------------------------------
1510 1520 1530 1540 1550 1560
pF1KE2 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
XP_005 ------------------------------------------------------------
1570 1580 1590 1600 1610 1620
pF1KE2 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
XP_005 ------------------------------------------------------------
1630 1640 1650 1660 1670 1680
pF1KE2 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
XP_005 ------------------------------------------------------------
1690 1700 1710 1720 1730 1740
pF1KE2 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
XP_005 ------------------------------------------------------------
1750 1760 1770 1780 1790 1800
pF1KE2 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
XP_005 ------------------------------------------------------------
1810 1820 1830 1840 1850 1860
pF1KE2 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
XP_005 ------------------------------------------------------------
1870 1880 1890 1900 1910 1920
pF1KE2 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
::::::::::::::::::::::::::::::::::::::::::::
XP_005 ----------------SSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
910 920 930 940
1930 1940 1950 1960 1970 1980
pF1KE2 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
950 960 970 980 990 1000
1990 2000 2010 2020 2030 2040
pF1KE2 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
1010 1020 1030 1040 1050 1060
2050 2060 2070 2080 2090 2100
pF1KE2 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
1070 1080 1090 1100 1110 1120
2110 2120 2130 2140 2150 2160
pF1KE2 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
1130 1140 1150 1160 1170 1180
2170 2180 2190 2200 2210 2220
pF1KE2 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
1190 1200 1210 1220 1230 1240
2230 2240 2250 2260 2270 2280
pF1KE2 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
1250 1260 1270 1280 1290 1300
2290 2300 2310 2320 2330 2340
pF1KE2 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
1310 1320 1330 1340 1350 1360
2350 2360 2370 2380 2390 2400
pF1KE2 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
1370 1380 1390 1400 1410 1420
2410 2420 2430 2440 2450 2460
pF1KE2 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
1430 1440 1450 1460 1470 1480
2470 2480 2490 2500 2510 2520
pF1KE2 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
1490 1500 1510 1520 1530 1540
2530 2540 2550 2560 2570 2580
pF1KE2 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
1550 1560 1570 1580 1590 1600
2590 2600 2610
pF1KE2 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEK------------------------
::::::::::::::::::::::::::::::::::::
XP_005 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKGFNFSLFKSNPMAFWTSTPSSQPE
1610 1620 1630 1640 1650 1660
2620 2630 2640 2650 2660 2670
pF1KE2 --AKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKAKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
1670 1680 1690 1700 1710 1720
2680 2690 2700 2710 2720 2730
pF1KE2 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
1730 1740 1750 1760 1770 1780
2740 2750 2760 2770 2780
pF1KE2 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQ--------KSQTEEITSTTDSVYTGGTEVM
:::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_005 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQYFVTSSLQKSQTEEITSTTDSVYTGGTEVM
1790 1800 1810 1820 1830 1840
2790 2800 2810 2820 2830 2840
pF1KE2 VPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSST
1850 1860 1870 1880 1890 1900
2850 2860 2870 2880 2890 2900
pF1KE2 GLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVH
1910 1920 1930 1940 1950 1960
2910 2920 2930 2940 2950 2960
pF1KE2 NEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMK
1970 1980 1990 2000 2010 2020
2970 2980 2990 3000 3010 3020
pF1KE2 NYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKT
2030 2040 2050 2060 2070 2080
3030 3040 3050 3060 3070 3080
pF1KE2 KEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFS
2090 2100 2110 2120 2130 2140
3090 3100 3110 3120 3130 3140
pF1KE2 NIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDE
2150 2160 2170 2180 2190 2200
3150 3160 3170 3180 3190 3200
pF1KE2 NFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFG
2210 2220 2230 2240 2250 2260
3210 3220
pF1KE2 SPKGSVCRRITITECGQI
::::::::::::::::::
XP_005 SPKGSVCRRITITECGQI
2270 2280
>>XP_011509880 (OMIM: 601181,608033) PREDICTED: E3 SUMO- (2281 aa)
initn: 9446 init1: 5838 opt: 5978 Z-score: 4264.6 bits: 803.5 E(85289): 0
Smith-Waterman score: 12800; 69.0% identity (69.0% similar) in 3258 aa overlap (1-3224:1-2281)
10 20 30 40 50 60
pF1KE2 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
:::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::
XP_011 MRRSKADVERYIASVQGSTPSPRQ-SMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLER
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKR
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKM
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLN
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLT
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESIC
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIH
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE2 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIG
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE2 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE2 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIK
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE2 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE2 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHR
780 790 800 810 820 830
850 860 870 880 890 900
pF1KE2 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
840 850 860 870 880 890
910 920 930 940 950 960
pF1KE2 PVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDD
XP_011 ------------------------------------------------------------
970 980 990 1000 1010 1020
pF1KE2 YFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLP
XP_011 ------------------------------------------------------------
1030 1040 1050 1060 1070 1080
pF1KE2 TQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDG
XP_011 ------------------------------------------------------------
1090 1100 1110 1120 1130 1140
pF1KE2 YSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKS
XP_011 ------------------------------------------------------------
1150 1160 1170 1180 1190 1200
pF1KE2 VFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAK
XP_011 ------------------------------------------------------------
1210 1220 1230 1240 1250 1260
pF1KE2 LFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGS
XP_011 ------------------------------------------------------------
1270 1280 1290 1300 1310 1320
pF1KE2 DRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAV
XP_011 ------------------------------------------------------------
1330 1340 1350 1360 1370 1380
pF1KE2 RIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNP
XP_011 ------------------------------------------------------------
1390 1400 1410 1420 1430 1440
pF1KE2 SNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQN
XP_011 ------------------------------------------------------------
1450 1460 1470 1480 1490 1500
pF1KE2 TKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCA
XP_011 ------------------------------------------------------------
1510 1520 1530 1540 1550 1560
pF1KE2 ACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANA
XP_011 ------------------------------------------------------------
1570 1580 1590 1600 1610 1620
pF1KE2 TRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNE
XP_011 ------------------------------------------------------------
1630 1640 1650 1660 1670 1680
pF1KE2 ASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEA
XP_011 ------------------------------------------------------------
1690 1700 1710 1720 1730 1740
pF1KE2 SATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEAS
XP_011 ------------------------------------------------------------
1750 1760 1770 1780 1790 1800
pF1KE2 ATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLK
XP_011 ------------------------------------------------------------
1810 1820 1830 1840 1850 1860
pF1KE2 CVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFK
XP_011 ------------------------------------------------------------
1870 1880 1890 1900 1910 1920
pF1KE2 FGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
::::::::::::::::::::::::::::::::::::::::::::
XP_011 ----------------SSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGT
900 910 920 930 940
1930 1940 1950 1960 1970 1980
pF1KE2 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFS
950 960 970 980 990 1000
1990 2000 2010 2020 2030 2040
pF1KE2 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRV
1010 1020 1030 1040 1050 1060
2050 2060 2070 2080 2090 2100
pF1KE2 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSG
1070 1080 1090 1100 1110 1120
2110 2120 2130 2140 2150 2160
pF1KE2 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDT
1130 1140 1150 1160 1170 1180
2170 2180 2190 2200 2210 2220
pF1KE2 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGP
1190 1200 1210 1220 1230 1240
2230 2240 2250 2260 2270 2280
pF1KE2 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKS
1250 1260 1270 1280 1290 1300
2290 2300 2310 2320 2330 2340
pF1KE2 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLY
1310 1320 1330 1340 1350 1360
2350 2360 2370 2380 2390 2400
pF1KE2 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTER
1370 1380 1390 1400 1410 1420
2410 2420 2430 2440 2450 2460
pF1KE2 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPR
1430 1440 1450 1460 1470 1480
2470 2480 2490 2500 2510 2520
pF1KE2 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSES
1490 1500 1510 1520 1530 1540
2530 2540 2550 2560 2570 2580
pF1KE2 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELS
1550 1560 1570 1580 1590 1600
2590 2600 2610
pF1KE2 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEK------------------------
::::::::::::::::::::::::::::::::::::
XP_011 KNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKGFNFSLFKSNPMAFWTSTPSSQPE
1610 1620 1630 1640 1650 1660
2620 2630 2640 2650 2660 2670
pF1KE2 --AKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKAKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDD
1670 1680 1690 1700 1710 1720
2680 2690 2700 2710 2720 2730
pF1KE2 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPT
1730 1740 1750 1760 1770 1780
2740 2750 2760 2770 2780
pF1KE2 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQ--------KSQTEEITSTTDSVYTGGTEVM
:::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_011 FFCGVCSDTDEDNGNGEDFQSELQKVQEAQYFVTSSLQKSQTEEITSTTDSVYTGGTEVM
1790 1800 1810 1820 1830 1840
2790 2800 2810 2820 2830 2840
pF1KE2 VPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSST
1850 1860 1870 1880 1890 1900
2850 2860 2870 2880 2890 2900
pF1KE2 GLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVH
1910 1920 1930 1940 1950 1960
2910 2920 2930 2940 2950 2960
pF1KE2 NEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMK
1970 1980 1990 2000 2010 2020
2970 2980 2990 3000 3010 3020
pF1KE2 NYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKT
2030 2040 2050 2060 2070 2080
3030 3040 3050 3060 3070 3080
pF1KE2 KEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFS
2090 2100 2110 2120 2130 2140
3090 3100 3110 3120 3130 3140
pF1KE2 NIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDE
2150 2160 2170 2180 2190 2200
3150 3160 3170 3180 3190 3200
pF1KE2 NFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFG
2210 2220 2230 2240 2250 2260
3210 3220
pF1KE2 SPKGSVCRRITITECGQI
::::::::::::::::::
XP_011 SPKGSVCRRITITECGQI
2270 2280
3224 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 18:19:54 2016 done: Sun Nov 6 18:19:59 2016
Total Scan time: 27.750 Total Display time: 3.390
Function used was FASTA [36.3.4 Apr, 2011]