Result of FASTA (omim) for
pF1KE2369
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2369, 580 aa
1>>>pF1KE2369 580 - 580 aa - 580 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5172+/-0.000431; mu= 11.4282+/- 0.027
mean_var=229.2512+/-47.875, 0's: 0 Z-trim(117.3): 66 B-trim: 79 in 1/54
Lambda= 0.084707
statistics sampled from 29087 (29153) to 29087 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.668), E-opt: 0.2 (0.342), width: 16
Scan time: 10.950
The best scores are: opt bits E(85289)
NP_067627 (OMIM: 605879) small conductance calcium ( 579) 3735 469.9 9.8e-132
XP_011541691 (OMIM: 605879) PREDICTED: small condu ( 857) 3735 470.1 1.3e-131
XP_011541689 (OMIM: 605879) PREDICTED: small condu ( 857) 3735 470.1 1.3e-131
NP_002240 (OMIM: 602983) small conductance calcium ( 731) 2561 326.6 1.8e-88
XP_005259964 (OMIM: 602982) PREDICTED: small condu ( 623) 2364 302.4 2.8e-81
NP_002239 (OMIM: 602982) small conductance calcium ( 543) 2348 300.4 1e-80
XP_011526306 (OMIM: 602982) PREDICTED: small condu ( 626) 2348 300.5 1.1e-80
XP_005259963 (OMIM: 602982) PREDICTED: small condu ( 626) 2348 300.5 1.1e-80
XP_011526307 (OMIM: 602982) PREDICTED: small condu ( 546) 2332 298.5 3.9e-80
XP_005259962 (OMIM: 602982) PREDICTED: small condu ( 629) 2332 298.5 4.2e-80
NP_740752 (OMIM: 602983) small conductance calcium ( 426) 2199 282.1 2.6e-75
XP_016864946 (OMIM: 605879) PREDICTED: small condu ( 275) 1575 205.6 1.8e-52
NP_740721 (OMIM: 605879) small conductance calcium ( 231) 1472 192.9 9.7e-49
NP_001265133 (OMIM: 605879) small conductance calc ( 231) 1472 192.9 9.7e-49
NP_001191016 (OMIM: 602983) small conductance calc ( 746) 1386 183.0 3e-45
NP_002241 (OMIM: 602754,616689) intermediate condu ( 427) 1131 151.6 5e-36
XP_005258939 (OMIM: 602754,616689) PREDICTED: inte ( 395) 947 129.0 2.8e-29
XP_005258940 (OMIM: 602754,616689) PREDICTED: inte ( 364) 625 89.6 1.9e-17
XP_011525240 (OMIM: 602754,616689) PREDICTED: inte ( 259) 533 78.2 3.7e-14
>>NP_067627 (OMIM: 605879) small conductance calcium-act (579 aa)
initn: 3443 init1: 3443 opt: 3735 Z-score: 2486.0 bits: 469.9 E(85289): 9.8e-132
Smith-Waterman score: 3735; 99.8% identity (99.8% similar) in 580 aa overlap (1-580:1-579)
10 20 30 40 50 60
pF1KE2 MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAAV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
NP_067 MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAA-V
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 SSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 SSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGY
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 KLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 KLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 ILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 ILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTA
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 RLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 RLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTR
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 FVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 FVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSI
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 GYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 GYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRV
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 KNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 KNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTL
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 VDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 VDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDF
480 490 500 510 520 530
550 560 570 580
pF1KE2 IEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
::::::::::::::::::::::::::::::::::::::::
NP_067 IEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
540 550 560 570
>>XP_011541691 (OMIM: 605879) PREDICTED: small conductan (857 aa)
initn: 3443 init1: 3443 opt: 3735 Z-score: 2484.1 bits: 470.1 E(85289): 1.3e-131
Smith-Waterman score: 3735; 99.8% identity (99.8% similar) in 580 aa overlap (1-580:279-857)
10 20 30
pF1KE2 MSSCRYNGGVMRPLSNLSASRRNLHEMDSE
::::::::::::::::::::::::::::::
XP_011 SHHHHHPHPAHHQHHQPQARRESNPFTEIAMSSCRYNGGVMRPLSNLSASRRNLHEMDSE
250 260 270 280 290 300
40 50 60 70 80 90
pF1KE2 AQPLQPPASVGGGGGASSPSAAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGS
:::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_011 AQPLQPPASVGGGGGASSPSAAAAAAAA-VSSSAPEIVVSKPEHNNSNNLALYGTGGGGS
310 320 330 340 350 360
100 110 120 130 140 150
pF1KE2 TGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVM
370 380 390 400 410 420
160 170 180 190 200 210
pF1KE2 VIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAM
430 440 450 460 470 480
220 230 240 250 260 270
pF1KE2 TYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLI
490 500 510 520 530 540
280 290 300 310 320 330
pF1KE2 ARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTV
550 560 570 580 590 600
340 350 360 370 380 390
pF1KE2 RACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALV
610 620 630 640 650 660
400 410 420 430 440 450
pF1KE2 VAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVR
670 680 690 700 710 720
460 470 480 490 500 510
pF1KE2 KHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVT
730 740 750 760 770 780
520 530 540 550 560 570
pF1KE2 LETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSS
790 800 810 820 830 840
580
pF1KE2 TAPPTSSESS
::::::::::
XP_011 TAPPTSSESS
850
>>XP_011541689 (OMIM: 605879) PREDICTED: small conductan (857 aa)
initn: 3443 init1: 3443 opt: 3735 Z-score: 2484.1 bits: 470.1 E(85289): 1.3e-131
Smith-Waterman score: 3735; 99.8% identity (99.8% similar) in 580 aa overlap (1-580:279-857)
10 20 30
pF1KE2 MSSCRYNGGVMRPLSNLSASRRNLHEMDSE
::::::::::::::::::::::::::::::
XP_011 SHHHHHPHPAHHQHHQPQARRESNPFTEIAMSSCRYNGGVMRPLSNLSASRRNLHEMDSE
250 260 270 280 290 300
40 50 60 70 80 90
pF1KE2 AQPLQPPASVGGGGGASSPSAAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGS
:::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_011 AQPLQPPASVGGGGGASSPSAAAAAAAA-VSSSAPEIVVSKPEHNNSNNLALYGTGGGGS
310 320 330 340 350 360
100 110 120 130 140 150
pF1KE2 TGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVM
370 380 390 400 410 420
160 170 180 190 200 210
pF1KE2 VIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAM
430 440 450 460 470 480
220 230 240 250 260 270
pF1KE2 TYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLI
490 500 510 520 530 540
280 290 300 310 320 330
pF1KE2 ARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTV
550 560 570 580 590 600
340 350 360 370 380 390
pF1KE2 RACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALV
610 620 630 640 650 660
400 410 420 430 440 450
pF1KE2 VAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVR
670 680 690 700 710 720
460 470 480 490 500 510
pF1KE2 KHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVT
730 740 750 760 770 780
520 530 540 550 560 570
pF1KE2 LETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSS
790 800 810 820 830 840
580
pF1KE2 TAPPTSSESS
::::::::::
XP_011 TAPPTSSESS
850
>>NP_002240 (OMIM: 602983) small conductance calcium-act (731 aa)
initn: 2689 init1: 2525 opt: 2561 Z-score: 1709.5 bits: 326.6 E(85289): 1.8e-88
Smith-Waterman score: 2685; 73.6% identity (86.6% similar) in 580 aa overlap (1-580:175-728)
10 20 30
pF1KE2 MSSCRYNGGVMRPLSNLSASRRNLHEMDSE
::::.:.::::.::: :::::::: : ..:
NP_002 ATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETE
150 160 170 180 190 200
40 50 60 70 80 90
pF1KE2 AQPLQPPASVGGGGGASSPSAAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGS
.:::: ::: . ::::.:. : :.... :. .. .
NP_002 GQPLQ----------LFSPS------------NPPEIVISSREDNHAHQTLLHHPNATHN
210 220 230 240
100 110 120 130 140 150
pF1KE2 TGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVM
.: . .:.. :..:.:::::::::::::::::::::::::::::::::::::
NP_002 HQHAG----TTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVM
250 260 270 280 290
160 170 180 190 200 210
pF1KE2 VIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAM
::::::::: :.: :..::::::::::::::::::::.::.::.:::..:::::::::::
NP_002 VIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAM
300 310 320 330 340 350
220 230 240 250 260 270
pF1KE2 TYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLI
:::::..: ::.::::::::::.: : :::::::::.:: . ::::::::::::::::::
NP_002 TYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLI
360 370 380 390 400 410
280 290 300 310 320 330
pF1KE2 ARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTV
420 430 440 450 460 470
340 350 360 370 380 390
pF1KE2 RACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALV
:.:::::::::::::::::::::::::::::::::::.::::::::::::::::::::::
NP_002 RVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALV
480 490 500 510 520 530
400 410 420 430 440 450
pF1KE2 VAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVR
:::::::::::::::::::::::::::::.::::::::::::::::.:::.:::::::::
NP_002 VAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVR
540 550 560 570 580 590
460 470 480 490 500 510
pF1KE2 KHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVT
:::::::::::::::::::::::.:::::::::.: ::.:::.:..::.::::.::.: .
NP_002 KHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGS
600 610 620 630 640 650
520 530 540 550 560 570
pF1KE2 LETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSS
::.::: : .:...:: ::..:.::::.... : .:. :. .. .. :. ::
NP_002 LESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSS
660 670 680 690 700 710
580
pF1KE2 TAPPTSSESS
:. :: ::
NP_002 TSFPTPYTSSSSC
720 730
>>XP_005259964 (OMIM: 602982) PREDICTED: small conductan (623 aa)
initn: 2410 init1: 2359 opt: 2364 Z-score: 1580.2 bits: 302.4 E(85289): 2.8e-81
Smith-Waterman score: 2378; 70.5% identity (85.4% similar) in 536 aa overlap (1-534:84-588)
10 20
pF1KE2 MSSCRYNGGVMRPL-SNLSASRRNLHEMDS
:.: :::.: ::: :. .: :. :
XP_005 APQVSAGAQPLSHAGPRAACSEPNPCTQVVMNSHSYNGSVGRPLGSGPGALGRD--PPDP
60 70 80 90 100 110
30 40 50 60 70 80
pF1KE2 EA-QPLQPPASVGGGGGASSPSAAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGG
:: .: ::: : : ..: . : : ..:. ..:. .....
XP_005 EAGHPPQPPHSPG------LQVVVAKSEPARPSPGSPR---GQPQDQDDDE---------
120 130 140 150
90 100 110 120 130 140
pF1KE2 GSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIV
. . . .: . .. : .:.:..:::::::::::::::::::::::::::
XP_005 -----------DDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIV
160 170 180 190 200
150 160 170 180 190 200
pF1KE2 VMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRI
::: :::::::.: : ::::.:::::::::: :::::...::::::::::::::::::::
XP_005 VMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRI
210 220 230 240 250 260
210 220 230 240 250 260
pF1KE2 AMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLY
::: ::.:.: ::. ::::::.::.: :::::::::.::::.. ::::..::::::::::
XP_005 AMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLY
270 280 290 300 310 320
270 280 290 300 310 320
pF1KE2 LIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAW
:..::::::::.:::::::::::::::.::::::::::::::::::::::::: ::::::
XP_005 LLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAW
330 340 350 360 370 380
330 340 350 360 370 380
pF1KE2 TVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTA
:::.::::::.:.::::::::::::::::::::::::::.::::::::::::::::::::
XP_005 TVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTA
390 400 410 420 430 440
390 400 410 420 430 440
pF1KE2 LVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAK
::::::::::::::::::::::::::::::::::::::::::::::::.:.:::: :.:.
XP_005 LVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQAR
450 460 470 480 490 500
450 460 470 480 490 500
pF1KE2 VRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRI
:::::::::::::::::::.:: :::::::::.::::::..:::..:.:. . :..: :.
XP_005 VRKHQRKFLQAIHQLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARL
510 520 530 540 550 560
510 520 530 540 550 560
pF1KE2 VTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRS
.:::..:..: .:..::::::.:.::
XP_005 ATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDC
570 580 590 600 610 620
>>NP_002239 (OMIM: 602982) small conductance calcium-act (543 aa)
initn: 2082 init1: 2031 opt: 2348 Z-score: 1570.3 bits: 300.4 E(85289): 1e-80
Smith-Waterman score: 2362; 70.1% identity (85.0% similar) in 539 aa overlap (1-534:1-508)
10 20 30 40 50
pF1KE2 MSSCRYNGGVMRPL-SNLSASRRNLHEMDSEA-QPLQPPASVGGGGGASSPSAAAAAAAA
:.: :::.: ::: :. .: :. : :: .: ::: : : ..: . :
NP_002 MNSHSYNGSVGRPLGSGPGALGRD--PPDPEAGHPPQPPHSPG------LQVVVAKSEPA
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 AVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNI
: ..:. ..:. ..... . . . .: . .. : .:.
NP_002 RPSPGSPR---GQPQDQDDDE--------------------DDEEDEAGRQRASGKPSNV
60 70 80
120 130 140 150 160 170
pF1KE2 GYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLS
:..:::::::::::::::::::::::::::::: :::::::.: : ::::.:::::::::
NP_002 GHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLS
90 100 110 120 130 140
180 190 200 210 220 230
pF1KE2 TIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTW
: :::::...::::::::::::::::::::::: ::.:.: ::. ::::::.::.: :::
NP_002 TAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTW
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE2 TARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFN
::::::.::::.. ::::..:::::::::::..::::::::.:::::::::::::::.::
NP_002 TARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFN
210 220 230 240 250 260
300 310 320 330 340 350
pF1KE2 TRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFL
::::::::::::::::::::::: :::::::::.::::::.:.:::::::::::::::::
NP_002 TRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFL
270 280 290 300 310 320
360 370 380 390 400 410
pF1KE2 SIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTK
:::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTK
330 340 350 360 370 380
420 430 440 450 460 470
pF1KE2 RVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQ---LRSVKMEQRKLND
::::::::::::::::::.:.:::: :.:.:::::::::::::: :::::.:: ::::
NP_002 RVKNAAANVLRETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLND
390 400 410 420 430 440
480 490 500 510 520 530
pF1KE2 QANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQ
:::::.::::::..:::..:.:. . :..: :..:::..:..: .:..::::::.:.::
NP_002 QANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALPGLIAQAIRP
450 460 470 480 490 500
540 550 560 570 580
pF1KE2 QQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
NP_002 PPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG
510 520 530 540
>>XP_011526306 (OMIM: 602982) PREDICTED: small conductan (626 aa)
initn: 1327 init1: 1276 opt: 2348 Z-score: 1569.6 bits: 300.5 E(85289): 1.1e-80
Smith-Waterman score: 2362; 70.1% identity (85.0% similar) in 539 aa overlap (1-534:84-591)
10 20
pF1KE2 MSSCRYNGGVMRPL-SNLSASRRNLHEMDS
:.: :::.: ::: :. .: :. :
XP_011 APQVSAGAQPLSHAGPRAACSEPNPCTQVVMNSHSYNGSVGRPLGSGPGALGRD--PPDP
60 70 80 90 100 110
30 40 50 60 70 80
pF1KE2 EA-QPLQPPASVGGGGGASSPSAAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGG
:: .: ::: : : ..: . : : ..:. ..:. .....
XP_011 EAGHPPQPPHSPG------LQVVVAKSEPARPSPGSPR---GQPQDQDDDE---------
120 130 140 150
90 100 110 120 130 140
pF1KE2 GSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIV
. . . .: . .. : .:.:..:::::::::::::::::::::::::::
XP_011 -----------DDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIV
160 170 180 190 200
150 160 170 180 190 200
pF1KE2 VMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRI
::: :::::::.: : ::::.:::::::::: :::::...::::::::::::::::::::
XP_011 VMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRI
210 220 230 240 250 260
210 220 230 240 250 260
pF1KE2 AMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLY
::: ::.:.: ::. ::::::.::.: :::::::::.::::.. ::::..::::::::::
XP_011 AMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLY
270 280 290 300 310 320
270 280 290 300 310 320
pF1KE2 LIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAW
:..::::::::.:::::::::::::::.::::::::::::::::::::::::: ::::::
XP_011 LLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAW
330 340 350 360 370 380
330 340 350 360 370 380
pF1KE2 TVRACER---YHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAG
:::.::: :::.:.::::::::::::::::::::::::::.:::::::::::::::::
XP_011 TVRVCERENMYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAG
390 400 410 420 430 440
390 400 410 420 430 440
pF1KE2 CTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKID
:::::::::::::::::::::::::::::::::::::::::::::::::::.:.:::: :
XP_011 CTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPD
450 460 470 480 490 500
450 460 470 480 490 500
pF1KE2 HAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFE
.:.:::::::::::::::::::.:: :::::::::.::::::..:::..:.:. . :..:
XP_011 QARVRKHQRKFLQAIHQLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELE
510 520 530 540 550 560
510 520 530 540 550 560
pF1KE2 KRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRR
:..:::..:..: .:..::::::.:.::
XP_011 ARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAP
570 580 590 600 610 620
>>XP_005259963 (OMIM: 602982) PREDICTED: small conductan (626 aa)
initn: 2082 init1: 2031 opt: 2348 Z-score: 1569.6 bits: 300.5 E(85289): 1.1e-80
Smith-Waterman score: 2362; 70.1% identity (85.0% similar) in 539 aa overlap (1-534:84-591)
10 20
pF1KE2 MSSCRYNGGVMRPL-SNLSASRRNLHEMDS
:.: :::.: ::: :. .: :. :
XP_005 APQVSAGAQPLSHAGPRAACSEPNPCTQVVMNSHSYNGSVGRPLGSGPGALGRD--PPDP
60 70 80 90 100 110
30 40 50 60 70 80
pF1KE2 EA-QPLQPPASVGGGGGASSPSAAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGG
:: .: ::: : : ..: . : : ..:. ..:. .....
XP_005 EAGHPPQPPHSPG------LQVVVAKSEPARPSPGSPR---GQPQDQDDDE---------
120 130 140 150
90 100 110 120 130 140
pF1KE2 GSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIV
. . . .: . .. : .:.:..:::::::::::::::::::::::::::
XP_005 -----------DDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIV
160 170 180 190 200
150 160 170 180 190 200
pF1KE2 VMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRI
::: :::::::.: : ::::.:::::::::: :::::...::::::::::::::::::::
XP_005 VMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRI
210 220 230 240 250 260
210 220 230 240 250 260
pF1KE2 AMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLY
::: ::.:.: ::. ::::::.::.: :::::::::.::::.. ::::..::::::::::
XP_005 AMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLY
270 280 290 300 310 320
270 280 290 300 310 320
pF1KE2 LIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAW
:..::::::::.:::::::::::::::.::::::::::::::::::::::::: ::::::
XP_005 LLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAW
330 340 350 360 370 380
330 340 350 360 370 380
pF1KE2 TVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTA
:::.::::::.:.::::::::::::::::::::::::::.::::::::::::::::::::
XP_005 TVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTA
390 400 410 420 430 440
390 400 410 420 430 440
pF1KE2 LVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAK
::::::::::::::::::::::::::::::::::::::::::::::::.:.:::: :.:.
XP_005 LVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQAR
450 460 470 480 490 500
450 460 470 480 490 500
pF1KE2 VRKHQRKFLQAIHQ---LRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFE
:::::::::::::: :::::.:: :::::::::.::::::..:::..:.:. . :..:
XP_005 VRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELE
510 520 530 540 550 560
510 520 530 540 550 560
pF1KE2 KRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRR
:..:::..:..: .:..::::::.:.::
XP_005 ARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAP
570 580 590 600 610 620
>>XP_011526307 (OMIM: 602982) PREDICTED: small conductan (546 aa)
initn: 2107 init1: 1276 opt: 2332 Z-score: 1559.7 bits: 298.5 E(85289): 3.9e-80
Smith-Waterman score: 2346; 69.7% identity (84.5% similar) in 542 aa overlap (1-534:1-511)
10 20 30 40 50
pF1KE2 MSSCRYNGGVMRPL-SNLSASRRNLHEMDSEA-QPLQPPASVGGGGGASSPSAAAAAAAA
:.: :::.: ::: :. .: :. : :: .: ::: : : ..: . :
XP_011 MNSHSYNGSVGRPLGSGPGALGRD--PPDPEAGHPPQPPHSPG------LQVVVAKSEPA
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 AVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNI
: ..:. ..:. ..... . . . .: . .. : .:.
XP_011 RPSPGSPR---GQPQDQDDDE--------------------DDEEDEAGRQRASGKPSNV
60 70 80
120 130 140 150 160 170
pF1KE2 GYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLS
:..:::::::::::::::::::::::::::::: :::::::.: : ::::.:::::::::
XP_011 GHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLS
90 100 110 120 130 140
180 190 200 210 220 230
pF1KE2 TIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTW
: :::::...::::::::::::::::::::::: ::.:.: ::. ::::::.::.: :::
XP_011 TAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTW
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE2 TARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFN
::::::.::::.. ::::..:::::::::::..::::::::.:::::::::::::::.::
XP_011 TARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFN
210 220 230 240 250 260
300 310 320 330 340 350
pF1KE2 TRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACER---YHDQQDVTSNFLGAMWLISI
::::::::::::::::::::::: :::::::::.::: :::.:.::::::::::::::
XP_011 TRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERENMYHDKQEVTSNFLGAMWLISI
270 280 290 300 310 320
360 370 380 390 400 410
pF1KE2 TFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQ
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQ
330 340 350 360 370 380
420 430 440 450 460 470
pF1KE2 LTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQ---LRSVKMEQRK
:::::::::::::::::::::.:.:::: :.:.:::::::::::::: :::::.:: :
XP_011 LTKRVKNAAANVLRETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGK
390 400 410 420 430 440
480 490 500 510 520 530
pF1KE2 LNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQT
::::::::.::::::..:::..:.:. . :..: :..:::..:..: .:..::::::.:.
XP_011 LNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALPGLIAQA
450 460 470 480 490 500
540 550 560 570 580
pF1KE2 IRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
::
XP_011 IRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG
510 520 530 540
>>XP_005259962 (OMIM: 602982) PREDICTED: small conductan (629 aa)
initn: 2107 init1: 1276 opt: 2332 Z-score: 1559.0 bits: 298.5 E(85289): 4.2e-80
Smith-Waterman score: 2346; 69.7% identity (84.5% similar) in 542 aa overlap (1-534:84-594)
10 20
pF1KE2 MSSCRYNGGVMRPL-SNLSASRRNLHEMDS
:.: :::.: ::: :. .: :. :
XP_005 APQVSAGAQPLSHAGPRAACSEPNPCTQVVMNSHSYNGSVGRPLGSGPGALGRD--PPDP
60 70 80 90 100 110
30 40 50 60 70 80
pF1KE2 EA-QPLQPPASVGGGGGASSPSAAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGG
:: .: ::: : : ..: . : : ..:. ..:. .....
XP_005 EAGHPPQPPHSPG------LQVVVAKSEPARPSPGSPR---GQPQDQDDDE---------
120 130 140 150
90 100 110 120 130 140
pF1KE2 GSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIV
. . . .: . .. : .:.:..:::::::::::::::::::::::::::
XP_005 -----------DDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIV
160 170 180 190 200
150 160 170 180 190 200
pF1KE2 VMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRI
::: :::::::.: : ::::.:::::::::: :::::...::::::::::::::::::::
XP_005 VMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRI
210 220 230 240 250 260
210 220 230 240 250 260
pF1KE2 AMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLY
::: ::.:.: ::. ::::::.::.: :::::::::.::::.. ::::..::::::::::
XP_005 AMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLY
270 280 290 300 310 320
270 280 290 300 310 320
pF1KE2 LIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAW
:..::::::::.:::::::::::::::.::::::::::::::::::::::::: ::::::
XP_005 LLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAW
330 340 350 360 370 380
330 340 350 360 370 380
pF1KE2 TVRACER---YHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAG
:::.::: :::.:.::::::::::::::::::::::::::.:::::::::::::::::
XP_005 TVRVCERENMYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAG
390 400 410 420 430 440
390 400 410 420 430 440
pF1KE2 CTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKID
:::::::::::::::::::::::::::::::::::::::::::::::::::.:.:::: :
XP_005 CTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPD
450 460 470 480 490 500
450 460 470 480 490 500
pF1KE2 HAKVRKHQRKFLQAIHQ---LRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSE
.:.:::::::::::::: :::::.:: :::::::::.::::::..:::..:.:. . :
XP_005 QARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHE
510 520 530 540 550 560
510 520 530 540 550 560
pF1KE2 DFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSS
..: :..:::..:..: .:..::::::.:.::
XP_005 ELEARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTP
570 580 590 600 610 620
570 580
pF1KE2 SRRRRSSSTAPPTSSESS
XP_005 VAPSDCG
580 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 17:10:40 2016 done: Sun Nov 6 17:10:42 2016
Total Scan time: 10.950 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]