FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2373, 1143 aa 1>>>pF1KE2373 1143 - 1143 aa - 1143 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9800+/-0.000336; mu= 21.8542+/- 0.021 mean_var=164.4843+/-40.594, 0's: 0 Z-trim(118.2): 73 B-trim: 1667 in 1/50 Lambda= 0.100003 statistics sampled from 30914 (30987) to 30914 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.698), E-opt: 0.2 (0.363), width: 16 Scan time: 16.510 The best scores are: opt bits E(85289) XP_011525852 (OMIM: 615475) PREDICTED: probable AT (1143) 7621 1112.9 0 XP_011525853 (OMIM: 615475) PREDICTED: probable AT (1143) 7621 1112.9 0 XP_005259500 (OMIM: 615475) PREDICTED: probable AT (1143) 7621 1112.9 0 NP_055496 (OMIM: 615475) probable ATP-dependent RN (1143) 7621 1112.9 0 XP_016883013 (OMIM: 615475) PREDICTED: probable AT ( 612) 4080 601.7 4.6e-171 NP_001309145 (OMIM: 600396) ATP-dependent RNA heli ( 945) 1222 189.6 7.9e-47 NP_001309146 (OMIM: 600396) ATP-dependent RNA heli (1129) 1222 189.7 8.8e-47 NP_001309149 (OMIM: 600396) ATP-dependent RNA heli (1152) 1222 189.7 8.9e-47 NP_001309148 (OMIM: 600396) ATP-dependent RNA heli (1169) 1222 189.7 9e-47 NP_001309147 (OMIM: 600396) ATP-dependent RNA heli (1179) 1222 189.7 9e-47 NP_001289552 (OMIM: 600396) ATP-dependent RNA heli (1181) 1222 189.7 9e-47 NP_001309150 (OMIM: 600396) ATP-dependent RNA heli (1218) 1222 189.7 9.2e-47 NP_004932 (OMIM: 600396) ATP-dependent RNA helicas (1220) 1222 189.7 9.2e-47 NP_064547 (OMIM: 614405) putative ATP-dependent RN ( 707) 1169 181.8 1.3e-44 XP_005256326 (OMIM: 605584) PREDICTED: pre-mRNA-sp (1192) 1155 180.0 7.4e-44 XP_016879402 (OMIM: 605584) PREDICTED: pre-mRNA-sp (1192) 1155 180.0 7.4e-44 NP_054722 (OMIM: 605584) pre-mRNA-splicing factor (1227) 1155 180.1 7.5e-44 XP_011521787 (OMIM: 605584) PREDICTED: pre-mRNA-sp (1227) 1155 180.1 7.5e-44 XP_011521786 (OMIM: 605584) PREDICTED: pre-mRNA-sp (1227) 1155 180.1 7.5e-44 XP_011513240 (OMIM: 603405) PREDICTED: putative pr ( 742) 1131 176.3 6.1e-43 XP_011513241 (OMIM: 603405) PREDICTED: putative pr ( 742) 1131 176.3 6.1e-43 NP_001157711 (OMIM: 603405) putative pre-mRNA-spli ( 981) 1131 176.5 7.2e-43 NP_003578 (OMIM: 603405) putative pre-mRNA-splicin (1041) 1131 176.5 7.5e-43 NP_001349 (OMIM: 603403) pre-mRNA-splicing factor ( 795) 1127 175.8 9.5e-43 XP_011513242 (OMIM: 603405) PREDICTED: putative pr ( 560) 893 141.8 1.1e-32 NP_001186628 (OMIM: 614405) putative ATP-dependent ( 534) 886 140.8 2.2e-32 XP_011513243 (OMIM: 603405) PREDICTED: putative pr ( 524) 884 140.5 2.6e-32 NP_065916 (OMIM: 612767) ATP-dependent RNA helicas (1008) 766 123.8 5.2e-27 NP_001332894 (OMIM: 612720) ATP-dependent RNA heli ( 733) 748 121.0 2.6e-26 NP_001332893 (OMIM: 612720) ATP-dependent RNA heli (1318) 748 121.4 3.7e-26 NP_061903 (OMIM: 612720) ATP-dependent RNA helicas (1369) 748 121.4 3.8e-26 XP_016871893 (OMIM: 607960) PREDICTED: putative pr ( 743) 720 117.0 4.3e-25 NP_060650 (OMIM: 607960) putative pre-mRNA-splicin ( 743) 720 117.0 4.3e-25 XP_016871894 (OMIM: 607960) PREDICTED: putative pr ( 743) 720 117.0 4.3e-25 NP_001107869 (OMIM: 612767) ATP-dependent RNA heli ( 994) 685 112.1 1.7e-23 XP_016865224 (OMIM: 616530) PREDICTED: probable AT ( 971) 684 112.0 1.9e-23 NP_001332905 (OMIM: 616530) probable ATP-dependent (1130) 684 112.1 2e-23 XP_016865222 (OMIM: 616530) PREDICTED: probable AT (1139) 684 112.1 2e-23 XP_011541888 (OMIM: 616530) PREDICTED: probable AT (1162) 684 112.1 2.1e-23 NP_001332904 (OMIM: 616530) probable ATP-dependent (1268) 684 112.1 2.2e-23 XP_016865220 (OMIM: 616530) PREDICTED: probable AT (1277) 684 112.1 2.2e-23 XP_011541884 (OMIM: 616530) PREDICTED: probable AT (1406) 684 112.2 2.3e-23 XP_016865219 (OMIM: 616530) PREDICTED: probable AT (1430) 684 112.2 2.3e-23 NP_073739 (OMIM: 616530) probable ATP-dependent RN (1430) 684 112.2 2.3e-23 XP_011541883 (OMIM: 616530) PREDICTED: probable AT (1439) 684 112.2 2.4e-23 XP_016880571 (OMIM: 607570) PREDICTED: probable AT ( 640) 643 105.8 8.7e-22 XP_016880572 (OMIM: 607570) PREDICTED: probable AT ( 640) 643 105.8 8.7e-22 XP_011523556 (OMIM: 607570) PREDICTED: probable AT ( 680) 643 105.8 9.1e-22 NP_001159773 (OMIM: 607570) probable ATP-dependent ( 702) 643 105.9 9.2e-22 XP_016880569 (OMIM: 607570) PREDICTED: probable AT ( 723) 643 105.9 9.4e-22 >>XP_011525852 (OMIM: 615475) PREDICTED: probable ATP-de (1143 aa) initn: 7621 init1: 7621 opt: 7621 Z-score: 5950.3 bits: 1112.9 E(85289): 0 Smith-Waterman score: 7621; 100.0% identity (100.0% similar) in 1143 aa overlap (1-1143:1-1143) 10 20 30 40 50 60 pF1KE2 MPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 WTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYDPRYRINLSVLGPATRGSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYDPRYRINLSVLGPATRGSQG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 VVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 RFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 TRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 PFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 DQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 SQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVGDP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 RTFPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTFPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 LHQLKRQHEEGAGRRRKVLRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHQLKRQHEEGAGRRRKVLRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 QLQAAASSAQDLSREQLALLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLQAAASSAQDLSREQLALLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLH 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 PTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 LQSLLLFSRSLDTNGDCSRLVADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQSLLLFSRSLDTNGDCSRLVADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAH 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 QAQQQLEEEEEDTPVSPKEVATLSKELLQFTASKIPYSLRRLTGLEVQNMYVGPQTIPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QAQQQLEEEEEDTPVSPKEVATLSKELLQFTASKIPYSLRRLTGLEVQNMYVGPQTIPAT 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 PHLPGLFGSSTLSPHPTKGGYAVTDFLTYNCLTNDTDLYSDCLRTFWTCPHCGLHAPLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PHLPGLFGSSTLSPHPTKGGYAVTDFLTYNCLTNDTDLYSDCLRTFWTCPHCGLHAPLTP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 LERIAHENTCPQAPQDGPPGAEEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LERIAHENTCPQAPQDGPPGAEEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRK 1090 1100 1110 1120 1130 1140 pF1KE2 QHV ::: XP_011 QHV >>XP_011525853 (OMIM: 615475) PREDICTED: probable ATP-de (1143 aa) initn: 7621 init1: 7621 opt: 7621 Z-score: 5950.3 bits: 1112.9 E(85289): 0 Smith-Waterman score: 7621; 100.0% identity (100.0% similar) in 1143 aa overlap (1-1143:1-1143) 10 20 30 40 50 60 pF1KE2 MPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 WTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYDPRYRINLSVLGPATRGSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYDPRYRINLSVLGPATRGSQG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 VVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 RFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 TRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 PFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 DQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 SQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVGDP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 RTFPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTFPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 LHQLKRQHEEGAGRRRKVLRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHQLKRQHEEGAGRRRKVLRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 QLQAAASSAQDLSREQLALLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLQAAASSAQDLSREQLALLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLH 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 PTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 LQSLLLFSRSLDTNGDCSRLVADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQSLLLFSRSLDTNGDCSRLVADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAH 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 QAQQQLEEEEEDTPVSPKEVATLSKELLQFTASKIPYSLRRLTGLEVQNMYVGPQTIPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QAQQQLEEEEEDTPVSPKEVATLSKELLQFTASKIPYSLRRLTGLEVQNMYVGPQTIPAT 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 PHLPGLFGSSTLSPHPTKGGYAVTDFLTYNCLTNDTDLYSDCLRTFWTCPHCGLHAPLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PHLPGLFGSSTLSPHPTKGGYAVTDFLTYNCLTNDTDLYSDCLRTFWTCPHCGLHAPLTP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 LERIAHENTCPQAPQDGPPGAEEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LERIAHENTCPQAPQDGPPGAEEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRK 1090 1100 1110 1120 1130 1140 pF1KE2 QHV ::: XP_011 QHV >>XP_005259500 (OMIM: 615475) PREDICTED: probable ATP-de (1143 aa) initn: 7621 init1: 7621 opt: 7621 Z-score: 5950.3 bits: 1112.9 E(85289): 0 Smith-Waterman score: 7621; 100.0% identity (100.0% similar) in 1143 aa overlap (1-1143:1-1143) 10 20 30 40 50 60 pF1KE2 MPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 WTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYDPRYRINLSVLGPATRGSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYDPRYRINLSVLGPATRGSQG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 VVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 RFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 TRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 PFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 DQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 SQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVGDP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 RTFPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RTFPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 LHQLKRQHEEGAGRRRKVLRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LHQLKRQHEEGAGRRRKVLRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 QLQAAASSAQDLSREQLALLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QLQAAASSAQDLSREQLALLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLH 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 PTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 LQSLLLFSRSLDTNGDCSRLVADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQSLLLFSRSLDTNGDCSRLVADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAH 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 QAQQQLEEEEEDTPVSPKEVATLSKELLQFTASKIPYSLRRLTGLEVQNMYVGPQTIPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QAQQQLEEEEEDTPVSPKEVATLSKELLQFTASKIPYSLRRLTGLEVQNMYVGPQTIPAT 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 PHLPGLFGSSTLSPHPTKGGYAVTDFLTYNCLTNDTDLYSDCLRTFWTCPHCGLHAPLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PHLPGLFGSSTLSPHPTKGGYAVTDFLTYNCLTNDTDLYSDCLRTFWTCPHCGLHAPLTP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 LERIAHENTCPQAPQDGPPGAEEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LERIAHENTCPQAPQDGPPGAEEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRK 1090 1100 1110 1120 1130 1140 pF1KE2 QHV ::: XP_005 QHV >>NP_055496 (OMIM: 615475) probable ATP-dependent RNA he (1143 aa) initn: 7621 init1: 7621 opt: 7621 Z-score: 5950.3 bits: 1112.9 E(85289): 0 Smith-Waterman score: 7621; 100.0% identity (100.0% similar) in 1143 aa overlap (1-1143:1-1143) 10 20 30 40 50 60 pF1KE2 MPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 WTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYDPRYRINLSVLGPATRGSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 WTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYDPRYRINLSVLGPATRGSQG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 VVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 RFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 TRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 PFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 DQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 SQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVGDP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 RTFPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RTFPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 LHQLKRQHEEGAGRRRKVLRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LHQLKRQHEEGAGRRRKVLRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 QLQAAASSAQDLSREQLALLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QLQAAASSAQDLSREQLALLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLH 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 PTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 LQSLLLFSRSLDTNGDCSRLVADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LQSLLLFSRSLDTNGDCSRLVADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAH 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 QAQQQLEEEEEDTPVSPKEVATLSKELLQFTASKIPYSLRRLTGLEVQNMYVGPQTIPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QAQQQLEEEEEDTPVSPKEVATLSKELLQFTASKIPYSLRRLTGLEVQNMYVGPQTIPAT 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 PHLPGLFGSSTLSPHPTKGGYAVTDFLTYNCLTNDTDLYSDCLRTFWTCPHCGLHAPLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PHLPGLFGSSTLSPHPTKGGYAVTDFLTYNCLTNDTDLYSDCLRTFWTCPHCGLHAPLTP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 LERIAHENTCPQAPQDGPPGAEEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LERIAHENTCPQAPQDGPPGAEEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRK 1090 1100 1110 1120 1130 1140 pF1KE2 QHV ::: NP_055 QHV >>XP_016883013 (OMIM: 615475) PREDICTED: probable ATP-de (612 aa) initn: 4080 init1: 4080 opt: 4080 Z-score: 3192.2 bits: 601.7 E(85289): 4.6e-171 Smith-Waterman score: 4080; 100.0% identity (100.0% similar) in 612 aa overlap (532-1143:1-612) 510 520 530 540 550 560 pF1KE2 RLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAILYL :::::::::::::::::::::::::::::: XP_016 MKSMSVGDPRTFPFIEPPPPASLETAILYL 10 20 30 570 580 590 600 610 620 pF1KE2 RDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPFTRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPFTRS 40 50 60 70 80 90 630 640 650 660 670 680 pF1KE2 AQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLYEMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLYEMA 100 110 120 130 140 150 690 700 710 720 730 740 pF1KE2 NLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKVLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKVLRL 160 170 180 190 200 210 750 760 770 780 790 800 pF1KE2 QEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAASSAQDLSREQLALLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAASSAQDLSREQLALLK 220 230 240 250 260 270 810 820 830 840 850 860 pF1KE2 LVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLHPTCVFAGSPEVLHAQELEASN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLHPTCVFAGSPEVLHAQELEASN 280 290 300 310 320 330 870 880 890 900 910 920 pF1KE2 CDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPALQSLLLFSRSLDTNGDCSRLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPALQSLLLFSRSLDTNGDCSRLV 340 350 360 370 380 390 930 940 950 960 970 980 pF1KE2 ADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAHQAQQQLEEEEEDTPVSPKEVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAHQAQQQLEEEEEDTPVSPKEVA 400 410 420 430 440 450 990 1000 1010 1020 1030 1040 pF1KE2 TLSKELLQFTASKIPYSLRRLTGLEVQNMYVGPQTIPATPHLPGLFGSSTLSPHPTKGGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLSKELLQFTASKIPYSLRRLTGLEVQNMYVGPQTIPATPHLPGLFGSSTLSPHPTKGGY 460 470 480 490 500 510 1050 1060 1070 1080 1090 1100 pF1KE2 AVTDFLTYNCLTNDTDLYSDCLRTFWTCPHCGLHAPLTPLERIAHENTCPQAPQDGPPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVTDFLTYNCLTNDTDLYSDCLRTFWTCPHCGLHAPLTPLERIAHENTCPQAPQDGPPGA 520 530 540 550 560 570 1110 1120 1130 1140 pF1KE2 EEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRKQHV :::::::::::::::::::::::::::::::::::::::::: XP_016 EEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRKQHV 580 590 600 610 >>NP_001309145 (OMIM: 600396) ATP-dependent RNA helicase (945 aa) initn: 1251 init1: 434 opt: 1222 Z-score: 961.7 bits: 189.6 E(85289): 7.9e-47 Smith-Waterman score: 1324; 37.5% identity (67.2% similar) in 606 aa overlap (119-714:251-830) 90 100 110 120 130 140 pF1KE2 SIPALADLPRTYDPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLDFGQKQA .:.: .: . . :... : . :.: . NP_001 AEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIG-MMPND-IPEWKK---HAFG-GNKAS 230 240 250 260 270 150 160 170 180 190 200 pF1KE2 FGRLAKLQ--RERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFS- .:. .... ..: .::: . ....:.....:...: :.:: ::.::. ::: ::.. NP_001 YGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTS 280 290 300 310 320 330 210 220 230 240 250 260 pF1KE2 --HVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQ ...::::::.: .:.::::. : :..::: ::::. : : : ..: :.:::. NP_001 RGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRE 340 350 360 370 380 390 270 280 290 300 310 320 pF1KE2 IQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYF .:.: :: ....::.::: .:.: :.:.:.. . : :.:.:. :::.. ::.:: NP_001 CLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYF 400 410 420 430 440 450 330 340 350 360 370 380 pF1KE2 SNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLV .::. .::: .:. ..: :: : . :: .. :.. : :: ::.:: NP_001 YEAPIFTIPGRTYPVEILY---TKEPET---DYLDAS-LITVMQ-IHLTEPP---GDILV 460 470 480 490 500 390 400 410 420 430 pF1KE2 FLSGMAEISA----VLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILS ::.:. ::.. . : .. . . . ..::..::: : ..:: :::: :: ... NP_001 FLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIA 510 520 530 540 550 560 440 450 460 470 480 490 pF1KE2 TNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGV :::::::.::::: .::: : ::. :. .. ...: ::::.:.:: ::::::::: NP_001 TNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGK 570 580 590 600 610 620 500 510 520 530 540 550 pF1KE2 CFRLYAESDY-DAFAPYPVPEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAI :.:::.: : : . ::::.:. : : ::..:.:...: .: :.. :: .: ::. NP_001 CYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAM 630 640 650 660 670 680 560 570 580 590 600 610 pF1KE2 LYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPF : ::::. :: .: .:..:.. .. ::::.. .. : .:::.. ::::. : NP_001 EQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVF 690 700 710 720 730 740 620 630 640 650 660 670 pF1KE2 TRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLY : ... . ... .:: .::. :.:.: . .. : :: . :. . : NP_001 YRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSW-----KNNKFSNPWCYENFIQARSLR 750 760 770 780 790 680 690 700 710 720 730 pF1KE2 EMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKV . ..:.:. ... : : .... : : :.:. NP_001 RAQDIRKQMLGIMDRHKL----DVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLID 800 810 820 830 840 850 740 750 760 770 780 790 pF1KE2 LRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAASSAQDLSREQLA NP_001 QQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKL 860 870 880 890 900 910 >>NP_001309146 (OMIM: 600396) ATP-dependent RNA helicase (1129 aa) initn: 1249 init1: 434 opt: 1222 Z-score: 960.9 bits: 189.7 E(85289): 8.8e-47 Smith-Waterman score: 1324; 37.5% identity (67.2% similar) in 606 aa overlap (119-714:435-1014) 90 100 110 120 130 140 pF1KE2 SIPALADLPRTYDPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLDFGQKQA .:.: .: . . :... : . :.: . NP_001 AEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIG-MMPND-IPEWKK---HAFG-GNKAS 410 420 430 440 450 150 160 170 180 190 200 pF1KE2 FGRLAKLQ--RERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFS- .:. .... ..: .::: . ....:.....:...: :.:: ::.::. ::: ::.. NP_001 YGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTS 460 470 480 490 500 510 210 220 230 240 250 260 pF1KE2 --HVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQ ...::::::.: .:.::::. : :..::: ::::. : : : ..: :.:::. NP_001 RGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRE 520 530 540 550 560 570 270 280 290 300 310 320 pF1KE2 IQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYF .:.: :: ....::.::: .:.: :.:.:.. . : :.:.:. :::.. ::.:: NP_001 CLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYF 580 590 600 610 620 630 330 340 350 360 370 380 pF1KE2 SNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLV .::. .::: .:. ..: :: : . :: .. :.. : :: ::.:: NP_001 YEAPIFTIPGRTYPVEILY---TKEPET---DYLDAS-LITVMQ-IHLTEPP---GDILV 640 650 660 670 680 390 400 410 420 430 pF1KE2 FLSGMAEISA----VLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILS ::.:. ::.. . : .. . . . ..::..::: : ..:: :::: :: ... NP_001 FLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIA 690 700 710 720 730 740 440 450 460 470 480 490 pF1KE2 TNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGV :::::::.::::: .::: : ::. :. .. ...: ::::.:.:: ::::::::: NP_001 TNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGK 750 760 770 780 790 800 500 510 520 530 540 550 pF1KE2 CFRLYAESDY-DAFAPYPVPEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAI :.:::.: : : . ::::.:. : : ::..:.:...: .: :.. :: .: ::. NP_001 CYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAM 810 820 830 840 850 860 560 570 580 590 600 610 pF1KE2 LYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPF : ::::. :: .: .:..:.. .. ::::.. .. : .:::.. ::::. : NP_001 EQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVF 870 880 890 900 910 920 620 630 640 650 660 670 pF1KE2 TRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLY : ... . ... .:: .::. :.:.: . .. : :: . :. . : NP_001 YRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSW-----KNNKFSNPWCYENFIQARSLR 930 940 950 960 970 980 680 690 700 710 720 730 pF1KE2 EMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKV . ..:.:. ... : : .... : : :.:. NP_001 RAQDIRKQMLGIMDRHKL----DVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLID 990 1000 1010 1020 1030 740 750 760 770 780 790 pF1KE2 LRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAASSAQDLSREQLA NP_001 QQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKL 1040 1050 1060 1070 1080 1090 >>NP_001309149 (OMIM: 600396) ATP-dependent RNA helicase (1152 aa) initn: 1249 init1: 434 opt: 1222 Z-score: 960.8 bits: 189.7 E(85289): 8.9e-47 Smith-Waterman score: 1324; 37.5% identity (67.2% similar) in 606 aa overlap (119-714:526-1105) 90 100 110 120 130 140 pF1KE2 SIPALADLPRTYDPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLDFGQKQA .:.: .: . . :... : . :.: . NP_001 AEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIG-MMPND-IPEWKK---HAFG-GNKAS 500 510 520 530 540 150 160 170 180 190 200 pF1KE2 FGRLAKLQ--RERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFS- .:. .... ..: .::: . ....:.....:...: :.:: ::.::. ::: ::.. NP_001 YGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTS 550 560 570 580 590 600 210 220 230 240 250 260 pF1KE2 --HVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQ ...::::::.: .:.::::. : :..::: ::::. : : : ..: :.:::. NP_001 RGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRE 610 620 630 640 650 660 270 280 290 300 310 320 pF1KE2 IQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYF .:.: :: ....::.::: .:.: :.:.:.. . : :.:.:. :::.. ::.:: NP_001 CLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYF 670 680 690 700 710 720 330 340 350 360 370 380 pF1KE2 SNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLV .::. .::: .:. ..: :: : . :: .. :.. : :: ::.:: NP_001 YEAPIFTIPGRTYPVEILY---TKEPET---DYLDAS-LITVMQ-IHLTEPP---GDILV 730 740 750 760 770 390 400 410 420 430 pF1KE2 FLSGMAEISA----VLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILS ::.:. ::.. . : .. . . . ..::..::: : ..:: :::: :: ... NP_001 FLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIA 780 790 800 810 820 830 440 450 460 470 480 490 pF1KE2 TNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGV :::::::.::::: .::: : ::. :. .. ...: ::::.:.:: ::::::::: NP_001 TNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGK 840 850 860 870 880 890 500 510 520 530 540 550 pF1KE2 CFRLYAESDY-DAFAPYPVPEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAI :.:::.: : : . ::::.:. : : ::..:.:...: .: :.. :: .: ::. NP_001 CYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAM 900 910 920 930 940 950 560 570 580 590 600 610 pF1KE2 LYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPF : ::::. :: .: .:..:.. .. ::::.. .. : .:::.. ::::. : NP_001 EQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVF 960 970 980 990 1000 1010 620 630 640 650 660 670 pF1KE2 TRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLY : ... . ... .:: .::. :.:.: . .. : :: . :. . : NP_001 YRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSW-----KNNKFSNPWCYENFIQARSLR 1020 1030 1040 1050 1060 1070 680 690 700 710 720 730 pF1KE2 EMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKV . ..:.:. ... : : .... : : :.:. NP_001 RAQDIRKQMLGIMDRHKL----DVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLID 1080 1090 1100 1110 1120 740 750 760 770 780 790 pF1KE2 LRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAASSAQDLSREQLA NP_001 QQVVYIHPSSALFNRQPECISQD 1130 1140 1150 >>NP_001309148 (OMIM: 600396) ATP-dependent RNA helicase (1169 aa) initn: 1249 init1: 434 opt: 1222 Z-score: 960.7 bits: 189.7 E(85289): 9e-47 Smith-Waterman score: 1324; 37.5% identity (67.2% similar) in 606 aa overlap (119-714:526-1105) 90 100 110 120 130 140 pF1KE2 SIPALADLPRTYDPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLDFGQKQA .:.: .: . . :... : . :.: . NP_001 AEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIG-MMPND-IPEWKK---HAFG-GNKAS 500 510 520 530 540 150 160 170 180 190 200 pF1KE2 FGRLAKLQ--RERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFS- .:. .... ..: .::: . ....:.....:...: :.:: ::.::. ::: ::.. NP_001 YGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTS 550 560 570 580 590 600 210 220 230 240 250 260 pF1KE2 --HVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQ ...::::::.: .:.::::. : :..::: ::::. : : : ..: :.:::. NP_001 RGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRE 610 620 630 640 650 660 270 280 290 300 310 320 pF1KE2 IQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYF .:.: :: ....::.::: .:.: :.:.:.. . : :.:.:. :::.. ::.:: NP_001 CLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYF 670 680 690 700 710 720 330 340 350 360 370 380 pF1KE2 SNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLV .::. .::: .:. ..: :: : . :: .. :.. : :: ::.:: NP_001 YEAPIFTIPGRTYPVEILY---TKEPET---DYLDAS-LITVMQ-IHLTEPP---GDILV 730 740 750 760 770 390 400 410 420 430 pF1KE2 FLSGMAEISA----VLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILS ::.:. ::.. . : .. . . . ..::..::: : ..:: :::: :: ... NP_001 FLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIA 780 790 800 810 820 830 440 450 460 470 480 490 pF1KE2 TNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGV :::::::.::::: .::: : ::. :. .. ...: ::::.:.:: ::::::::: NP_001 TNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGK 840 850 860 870 880 890 500 510 520 530 540 550 pF1KE2 CFRLYAESDY-DAFAPYPVPEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAI :.:::.: : : . ::::.:. : : ::..:.:...: .: :.. :: .: ::. NP_001 CYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAM 900 910 920 930 940 950 560 570 580 590 600 610 pF1KE2 LYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPF : ::::. :: .: .:..:.. .. ::::.. .. : .:::.. ::::. : NP_001 EQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVF 960 970 980 990 1000 1010 620 630 640 650 660 670 pF1KE2 TRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLY : ... . ... .:: .::. :.:.: . .. : :: . :. . : NP_001 YRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSW-----KNNKFSNPWCYENFIQARSLR 1020 1030 1040 1050 1060 1070 680 690 700 710 720 730 pF1KE2 EMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKV . ..:.:. ... : : .... : : :.:. NP_001 RAQDIRKQMLGIMDRHKL----DVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLID 1080 1090 1100 1110 1120 740 750 760 770 780 790 pF1KE2 LRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAASSAQDLSREQLA NP_001 QQVVYIHPSSALFNRQPEWDLYSRFSEWKSGTNCSSLSGT 1130 1140 1150 1160 >>NP_001309147 (OMIM: 600396) ATP-dependent RNA helicase (1179 aa) initn: 1249 init1: 434 opt: 1222 Z-score: 960.7 bits: 189.7 E(85289): 9e-47 Smith-Waterman score: 1324; 37.5% identity (67.2% similar) in 606 aa overlap (119-714:524-1103) 90 100 110 120 130 140 pF1KE2 SIPALADLPRTYDPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLDFGQKQA .:.: .: . . :... : . :.: . NP_001 AEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIG-MMPND-IPEWKK---HAFG-GNKAS 500 510 520 530 540 150 160 170 180 190 200 pF1KE2 FGRLAKLQ--RERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFS- .:. .... ..: .::: . ....:.....:...: :.:: ::.::. ::: ::.. NP_001 YGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTS 550 560 570 580 590 600 210 220 230 240 250 260 pF1KE2 --HVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQ ...::::::.: .:.::::. : :..::: ::::. : : : ..: :.:::. NP_001 RGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRE 610 620 630 640 650 660 270 280 290 300 310 320 pF1KE2 IQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYF .:.: :: ....::.::: .:.: :.:.:.. . : :.:.:. :::.. ::.:: NP_001 CLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYF 670 680 690 700 710 720 330 340 350 360 370 380 pF1KE2 SNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLV .::. .::: .:. ..: :: : . :: .. :.. : :: ::.:: NP_001 YEAPIFTIPGRTYPVEILY---TKEPET---DYLDAS-LITVMQ-IHLTEPP---GDILV 730 740 750 760 770 390 400 410 420 430 pF1KE2 FLSGMAEISA----VLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILS ::.:. ::.. . : .. . . . ..::..::: : ..:: :::: :: ... NP_001 FLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIA 780 790 800 810 820 830 440 450 460 470 480 490 pF1KE2 TNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGV :::::::.::::: .::: : ::. :. .. ...: ::::.:.:: ::::::::: NP_001 TNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGK 840 850 860 870 880 890 500 510 520 530 540 550 pF1KE2 CFRLYAESDY-DAFAPYPVPEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAI :.:::.: : : . ::::.:. : : ::..:.:...: .: :.. :: .: ::. NP_001 CYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAM 900 910 920 930 940 950 560 570 580 590 600 610 pF1KE2 LYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPF : ::::. :: .: .:..:.. .. ::::.. .. : .:::.. ::::. : NP_001 EQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVF 960 970 980 990 1000 1010 620 630 640 650 660 670 pF1KE2 TRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLY : ... . ... .:: .::. :.:.: . .. : :: . :. . : NP_001 YRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSW-----KNNKFSNPWCYENFIQARSLR 1020 1030 1040 1050 1060 1070 680 690 700 710 720 730 pF1KE2 EMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKV . ..:.:. ... : : .... : : :.:. NP_001 RAQDIRKQMLGIMDRHKL----DVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLID 1080 1090 1100 1110 1120 740 750 760 770 780 790 pF1KE2 LRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAASSAQDLSREQLA NP_001 QQVVYIHPSSALFNRQPECPKHFLPVVAVAVSLEQCLSKFEDLNKELGLVTC 1130 1140 1150 1160 1170 1143 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 19:41:47 2016 done: Sun Nov 6 19:41:50 2016 Total Scan time: 16.510 Total Display time: 0.280 Function used was FASTA [36.3.4 Apr, 2011]