FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2380, 629 aa 1>>>pF1KE2380 629 - 629 aa - 629 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.3604+/-0.000484; mu= 24.6674+/- 0.030 mean_var=66.6477+/-13.678, 0's: 0 Z-trim(107.4): 73 B-trim: 11 in 1/53 Lambda= 0.157102 statistics sampled from 15438 (15511) to 15438 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.525), E-opt: 0.2 (0.182), width: 16 Scan time: 10.330 The best scores are: opt bits E(85289) XP_005266564 (OMIM: 104615) PREDICTED: high affini ( 629) 4100 939.2 0 NP_003036 (OMIM: 104615) high affinity cationic am ( 629) 4100 939.2 0 XP_016876205 (OMIM: 104615) PREDICTED: high affini ( 629) 4100 939.2 0 XP_016876202 (OMIM: 104615) PREDICTED: high affini ( 643) 3611 828.4 0 XP_016876203 (OMIM: 104615) PREDICTED: high affini ( 643) 3611 828.4 0 XP_016876204 (OMIM: 104615) PREDICTED: high affini ( 643) 3611 828.4 0 XP_005273667 (OMIM: 601872) PREDICTED: cationic am ( 658) 2508 578.4 2.7e-164 XP_005273668 (OMIM: 601872) PREDICTED: cationic am ( 658) 2508 578.4 2.7e-164 XP_016869235 (OMIM: 601872) PREDICTED: cationic am ( 658) 2508 578.4 2.7e-164 XP_005273669 (OMIM: 601872) PREDICTED: cationic am ( 658) 2508 578.4 2.7e-164 NP_001008539 (OMIM: 601872) cationic amino acid tr ( 658) 2508 578.4 2.7e-164 NP_001158243 (OMIM: 601872) cationic amino acid tr ( 698) 2508 578.4 2.8e-164 XP_016869236 (OMIM: 601872) PREDICTED: cationic am ( 657) 2453 565.9 1.5e-160 NP_003037 (OMIM: 601872) cationic amino acid trans ( 697) 2453 565.9 1.6e-160 NP_001041629 (OMIM: 300443) cationic amino acid tr ( 619) 1993 461.6 3.6e-129 XP_016885401 (OMIM: 300443) PREDICTED: cationic am ( 619) 1993 461.6 3.6e-129 NP_116192 (OMIM: 300443) cationic amino acid trans ( 619) 1993 461.6 3.6e-129 NP_004164 (OMIM: 603752) cationic amino acid trans ( 635) 913 216.9 1.8e-55 NP_066000 (OMIM: 615720,615725) probable cationic ( 771) 812 194.1 1.6e-48 NP_055146 (OMIM: 607933) cystine/glutamate transpo ( 501) 227 61.3 9.7e-09 XP_011530104 (OMIM: 607933) PREDICTED: cystine/glu ( 506) 227 61.3 9.7e-09 NP_877392 (OMIM: 604235) large neutral amino acids ( 332) 191 52.9 2.1e-06 NP_001070253 (OMIM: 605641) Y+L amino acid transpo ( 515) 192 53.4 2.4e-06 XP_011521740 (OMIM: 605641) PREDICTED: Y+L amino a ( 515) 192 53.4 2.4e-06 XP_011521736 (OMIM: 605641) PREDICTED: Y+L amino a ( 515) 192 53.4 2.4e-06 XP_011521735 (OMIM: 605641) PREDICTED: Y+L amino a ( 515) 192 53.4 2.4e-06 NP_003974 (OMIM: 605641) Y+L amino acid transporte ( 515) 192 53.4 2.4e-06 NP_001119577 (OMIM: 222700,603593) Y+L amino acid ( 511) 188 52.4 4.5e-06 XP_011535601 (OMIM: 222700,603593) PREDICTED: Y+L ( 511) 188 52.4 4.5e-06 NP_001119578 (OMIM: 222700,603593) Y+L amino acid ( 511) 188 52.4 4.5e-06 XP_011535600 (OMIM: 222700,603593) PREDICTED: Y+L ( 511) 188 52.4 4.5e-06 XP_006720365 (OMIM: 222700,603593) PREDICTED: Y+L ( 511) 188 52.4 4.5e-06 XP_016881719 (OMIM: 220100,604144) PREDICTED: B(0, ( 399) 181 50.7 1.1e-05 XP_016879226 (OMIM: 600182) PREDICTED: large neutr ( 332) 174 49.1 3e-05 XP_006721349 (OMIM: 600182) PREDICTED: large neutr ( 352) 174 49.1 3.1e-05 XP_011521741 (OMIM: 605641) PREDICTED: Y+L amino a ( 307) 172 48.6 3.9e-05 NP_003477 (OMIM: 600182) large neutral amino acids ( 507) 174 49.3 4e-05 XP_016879224 (OMIM: 600182) PREDICTED: large neutr ( 509) 174 49.3 4e-05 XP_006723055 (OMIM: 220100,604144) PREDICTED: B(0, ( 260) 169 47.8 5.6e-05 XP_006723347 (OMIM: 607959) PREDICTED: asc-type am ( 444) 168 47.8 9.4e-05 NP_062823 (OMIM: 607959) asc-type amino acid trans ( 523) 168 47.9 0.00011 XP_016879225 (OMIM: 600182) PREDICTED: large neutr ( 467) 167 47.6 0.00011 XP_011525421 (OMIM: 607959) PREDICTED: asc-type am ( 660) 168 48.0 0.00012 NP_036376 (OMIM: 604235) large neutral amino acids ( 535) 166 47.5 0.00015 NP_001253966 (OMIM: 604235) large neutral amino ac ( 311) 159 45.6 0.0003 NP_065759 (OMIM: 606726,616645,616685) solute carr (1116) 159 46.2 0.00073 XP_016883470 (OMIM: 606726,616645,616685) PREDICTE (1134) 159 46.2 0.00074 NP_001128243 (OMIM: 606726,616645,616685) solute c (1139) 159 46.2 0.00074 >>XP_005266564 (OMIM: 104615) PREDICTED: high affinity c (629 aa) initn: 4100 init1: 4100 opt: 4100 Z-score: 5020.8 bits: 939.2 E(85289): 0 Smith-Waterman score: 4100; 100.0% identity (100.0% similar) in 629 aa overlap (1-629:1-629) 10 20 30 40 50 60 pF1KE2 MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY 550 560 570 580 590 600 610 620 pF1KE2 FGYGLWHSEEASLDADQARTPDGNLDQCK ::::::::::::::::::::::::::::: XP_005 FGYGLWHSEEASLDADQARTPDGNLDQCK 610 620 >>NP_003036 (OMIM: 104615) high affinity cationic amino (629 aa) initn: 4100 init1: 4100 opt: 4100 Z-score: 5020.8 bits: 939.2 E(85289): 0 Smith-Waterman score: 4100; 100.0% identity (100.0% similar) in 629 aa overlap (1-629:1-629) 10 20 30 40 50 60 pF1KE2 MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY 550 560 570 580 590 600 610 620 pF1KE2 FGYGLWHSEEASLDADQARTPDGNLDQCK ::::::::::::::::::::::::::::: NP_003 FGYGLWHSEEASLDADQARTPDGNLDQCK 610 620 >>XP_016876205 (OMIM: 104615) PREDICTED: high affinity c (629 aa) initn: 4100 init1: 4100 opt: 4100 Z-score: 5020.8 bits: 939.2 E(85289): 0 Smith-Waterman score: 4100; 100.0% identity (100.0% similar) in 629 aa overlap (1-629:1-629) 10 20 30 40 50 60 pF1KE2 MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY 550 560 570 580 590 600 610 620 pF1KE2 FGYGLWHSEEASLDADQARTPDGNLDQCK ::::::::::::::::::::::::::::: XP_016 FGYGLWHSEEASLDADQARTPDGNLDQCK 610 620 >>XP_016876202 (OMIM: 104615) PREDICTED: high affinity c (643 aa) initn: 3611 init1: 3611 opt: 3611 Z-score: 4421.7 bits: 828.4 E(85289): 0 Smith-Waterman score: 3611; 99.5% identity (99.8% similar) in 563 aa overlap (1-563:1-563) 10 20 30 40 50 60 pF1KE2 MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY :::::::::::::::::::. .: XP_016 VVTGVIWRQPESKTKLSFKTVLLNYWNRRHCHGLKPPPVSSGSLPASAPHPEHLRERLSH 550 560 570 580 590 600 >>XP_016876203 (OMIM: 104615) PREDICTED: high affinity c (643 aa) initn: 3611 init1: 3611 opt: 3611 Z-score: 4421.7 bits: 828.4 E(85289): 0 Smith-Waterman score: 3611; 99.5% identity (99.8% similar) in 563 aa overlap (1-563:1-563) 10 20 30 40 50 60 pF1KE2 MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY :::::::::::::::::::. .: XP_016 VVTGVIWRQPESKTKLSFKTVLLNYWNRRHCHGLKPPPVSSGSLPASAPHPEHLRERLSH 550 560 570 580 590 600 >>XP_016876204 (OMIM: 104615) PREDICTED: high affinity c (643 aa) initn: 3611 init1: 3611 opt: 3611 Z-score: 4421.7 bits: 828.4 E(85289): 0 Smith-Waterman score: 3611; 99.5% identity (99.8% similar) in 563 aa overlap (1-563:1-563) 10 20 30 40 50 60 pF1KE2 MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY :::::::::::::::::::. .: XP_016 VVTGVIWRQPESKTKLSFKTVLLNYWNRRHCHGLKPPPVSSGSLPASAPHPEHLRERLSH 550 560 570 580 590 600 >>XP_005273667 (OMIM: 601872) PREDICTED: cationic amino (658 aa) initn: 2023 init1: 1709 opt: 2508 Z-score: 3070.5 bits: 578.4 E(85289): 2.7e-164 Smith-Waterman score: 2508; 61.6% identity (84.9% similar) in 628 aa overlap (3-626:4-623) 10 20 30 40 50 pF1KE2 MGCKVLLNIGQQMLRRKVVDC-SREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVA :.. :.... ..:::.: : :.:.: :::.:.::.::::::::::::::::: :: XP_005 MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 RENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLI . ..::.::.::::::::::.:::::.:::::::::::::::.::::::::::::::::: XP_005 KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 LSYIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGL :::.:::::::::::.:::::... ::.: ::.. .: : ::: ::.::: .::.:.:: XP_005 LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGL 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 LTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTK :..:::::: :::.:: .:.::: :.::.:::::.: ::...:: . : :. . .. XP_005 LSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISAS-AREPPSE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 EGKP--GVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLI .: :.:::::.::.:.:.::::::::::::::::::::::.:::::::.:::.:::. XP_005 NGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLV 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 CFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMF ::.:::::::::::::::. ::..:::: ::..::: :::.::.:::::::.:::::.: XP_005 CFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIF 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 PMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGT ::::::::::::::::: ::..:..:::::::::.::::::.:::::::: :::.::::: XP_005 PMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGT 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 LLAYSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQN-ELASTNDSQLGFLPEAEMF :.::::::::::.::: ::.: :.. . : : : .. ...: ..::. .: . . : XP_005 LMAYSLVAACVLILRY---QPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTML-QRQGF 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE2 SLKTILSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGS :..:.. : .. :.. :. .:.. ....: :.. . ..:. : .:.:. :.. ::: XP_005 SMRTLFCP-SLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALF 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE2 ALLCAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLI .: .... .:::::... :..: ::::: :: .::.::.:::.::. :::::..:: : XP_005 LVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAI 540 550 560 570 580 590 600 610 620 pF1KE2 GFIIYFGYGLWHSEEASLDADQARTPDGNLDQCK ::.:::.::. :: :. : :. :. : XP_005 GFLIYFSYGIRHSLEGHLR-DENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFH 600 610 620 630 640 650 XP_005 EKTSEF >>XP_005273668 (OMIM: 601872) PREDICTED: cationic amino (658 aa) initn: 2023 init1: 1709 opt: 2508 Z-score: 3070.5 bits: 578.4 E(85289): 2.7e-164 Smith-Waterman score: 2508; 61.6% identity (84.9% similar) in 628 aa overlap (3-626:4-623) 10 20 30 40 50 pF1KE2 MGCKVLLNIGQQMLRRKVVDC-SREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVA :.. :.... ..:::.: : :.:.: :::.:.::.::::::::::::::::: :: XP_005 MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 RENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLI . ..::.::.::::::::::.:::::.:::::::::::::::.::::::::::::::::: XP_005 KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 LSYIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGL :::.:::::::::::.:::::... ::.: ::.. .: : ::: ::.::: .::.:.:: XP_005 LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGL 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 LTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTK :..:::::: :::.:: .:.::: :.::.:::::.: ::...:: . : :. . .. XP_005 LSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISAS-AREPPSE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 EGKP--GVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLI .: :.:::::.::.:.:.::::::::::::::::::::::.:::::::.:::.:::. XP_005 NGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLV 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 CFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMF ::.:::::::::::::::. ::..:::: ::..::: :::.::.:::::::.:::::.: XP_005 CFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIF 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 PMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGT ::::::::::::::::: ::..:..:::::::::.::::::.:::::::: :::.::::: XP_005 PMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGT 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 LLAYSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQN-ELASTNDSQLGFLPEAEMF :.::::::::::.::: ::.: :.. . : : : .. ...: ..::. .: . . : XP_005 LMAYSLVAACVLILRY---QPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTML-QRQGF 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE2 SLKTILSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGS :..:.. : .. :.. :. .:.. ....: :.. . ..:. : .:.:. :.. ::: XP_005 SMRTLFCP-SLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALF 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE2 ALLCAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLI .: .... .:::::... :..: ::::: :: .::.::.:::.::. :::::..:: : XP_005 LVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAI 540 550 560 570 580 590 600 610 620 pF1KE2 GFIIYFGYGLWHSEEASLDADQARTPDGNLDQCK ::.:::.::. :: :. : :. :. : XP_005 GFLIYFSYGIRHSLEGHLR-DENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFH 600 610 620 630 640 650 XP_005 EKTSEF >>XP_016869235 (OMIM: 601872) PREDICTED: cationic amino (658 aa) initn: 2023 init1: 1709 opt: 2508 Z-score: 3070.5 bits: 578.4 E(85289): 2.7e-164 Smith-Waterman score: 2508; 61.6% identity (84.9% similar) in 628 aa overlap (3-626:4-623) 10 20 30 40 50 pF1KE2 MGCKVLLNIGQQMLRRKVVDC-SREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVA :.. :.... ..:::.: : :.:.: :::.:.::.::::::::::::::::: :: XP_016 MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 RENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLI . ..::.::.::::::::::.:::::.:::::::::::::::.::::::::::::::::: XP_016 KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 LSYIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGL :::.:::::::::::.:::::... ::.: ::.. .: : ::: ::.::: .::.:.:: XP_016 LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGL 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 LTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTK :..:::::: :::.:: .:.::: :.::.:::::.: ::...:: . : :. . .. XP_016 LSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISAS-AREPPSE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 EGKP--GVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLI .: :.:::::.::.:.:.::::::::::::::::::::::.:::::::.:::.:::. XP_016 NGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLV 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 CFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMF ::.:::::::::::::::. ::..:::: ::..::: :::.::.:::::::.:::::.: XP_016 CFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIF 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 PMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGT ::::::::::::::::: ::..:..:::::::::.::::::.:::::::: :::.::::: XP_016 PMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGT 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 LLAYSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQN-ELASTNDSQLGFLPEAEMF :.::::::::::.::: ::.: :.. . : : : .. ...: ..::. .: . . : XP_016 LMAYSLVAACVLILRY---QPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTML-QRQGF 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE2 SLKTILSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGS :..:.. : .. :.. :. .:.. ....: :.. . ..:. : .:.:. :.. ::: XP_016 SMRTLFCP-SLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALF 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE2 ALLCAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLI .: .... .:::::... :..: ::::: :: .::.::.:::.::. :::::..:: : XP_016 LVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAI 540 550 560 570 580 590 600 610 620 pF1KE2 GFIIYFGYGLWHSEEASLDADQARTPDGNLDQCK ::.:::.::. :: :. : :. :. : XP_016 GFLIYFSYGIRHSLEGHLR-DENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFH 600 610 620 630 640 650 XP_016 EKTSEF >>XP_005273669 (OMIM: 601872) PREDICTED: cationic amino (658 aa) initn: 2023 init1: 1709 opt: 2508 Z-score: 3070.5 bits: 578.4 E(85289): 2.7e-164 Smith-Waterman score: 2508; 61.6% identity (84.9% similar) in 628 aa overlap (3-626:4-623) 10 20 30 40 50 pF1KE2 MGCKVLLNIGQQMLRRKVVDC-SREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVA :.. :.... ..:::.: : :.:.: :::.:.::.::::::::::::::::: :: XP_005 MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 RENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLI . ..::.::.::::::::::.:::::.:::::::::::::::.::::::::::::::::: XP_005 KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 LSYIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGL :::.:::::::::::.:::::... ::.: ::.. .: : ::: ::.::: .::.:.:: XP_005 LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGL 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 LTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTK :..:::::: :::.:: .:.::: :.::.:::::.: ::...:: . : :. . .. XP_005 LSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISAS-AREPPSE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 EGKP--GVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLI .: :.:::::.::.:.:.::::::::::::::::::::::.:::::::.:::.:::. XP_005 NGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLV 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 CFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMF ::.:::::::::::::::. ::..:::: ::..::: :::.::.:::::::.:::::.: XP_005 CFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIF 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 PMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGT ::::::::::::::::: ::..:..:::::::::.::::::.:::::::: :::.::::: XP_005 PMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGT 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 LLAYSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQN-ELASTNDSQLGFLPEAEMF :.::::::::::.::: ::.: :.. . : : : .. ...: ..::. .: . . : XP_005 LMAYSLVAACVLILRY---QPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTML-QRQGF 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE2 SLKTILSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGS :..:.. : .. :.. :. .:.. ....: :.. . ..:. : .:.:. :.. ::: XP_005 SMRTLFCP-SLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALF 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE2 ALLCAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLI .: .... .:::::... :..: ::::: :: .::.::.:::.::. :::::..:: : XP_005 LVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAI 540 550 560 570 580 590 600 610 620 pF1KE2 GFIIYFGYGLWHSEEASLDADQARTPDGNLDQCK ::.:::.::. :: :. : :. :. : XP_005 GFLIYFSYGIRHSLEGHLR-DENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFH 600 610 620 630 640 650 XP_005 EKTSEF 629 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 14:39:13 2016 done: Sun Nov 6 14:39:14 2016 Total Scan time: 10.330 Total Display time: 0.180 Function used was FASTA [36.3.4 Apr, 2011]