Result of FASTA (omim) for pF1KE2381
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE2381, 1490 aa
  1>>>pF1KE2381 1490 - 1490 aa - 1490 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 19.8588+/-0.000539; mu= -42.3378+/- 0.034
 mean_var=1075.9156+/-233.164, 0's: 0 Z-trim(124.8): 420  B-trim: 2752 in 1/61
 Lambda= 0.039101
 statistics sampled from 46709 (47209) to 46709 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.787), E-opt: 0.2 (0.554), width:  16
 Scan time: 22.860

The best scores are:                                      opt bits E(85289)
NP_057591 (OMIM: 615514) cyclin-dependent kinase 1 (1490) 9956 578.6 1.3e-163
XP_005257513 (OMIM: 615514) PREDICTED: cyclin-depe (1489) 9939 577.6 2.5e-163
XP_011523200 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_011523199 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_016880233 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_011523198 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_011523196 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_011523195 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_011523201 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_016880234 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_016880238 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_011523208 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_016880237 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_016880236 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_011523204 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_011523203 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_011523202 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_016880235 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_011523197 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_011523205 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
XP_011523207 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152
NP_055898 (OMIM: 615514) cyclin-dependent kinase 1 (1481) 8393 490.4 4.4e-137
XP_005257515 (OMIM: 615514) PREDICTED: cyclin-depe (1256) 8299 485.1 1.5e-135
XP_016880239 (OMIM: 615514) PREDICTED: cyclin-depe (1262) 8299 485.1 1.5e-135
XP_016880241 (OMIM: 615514) PREDICTED: cyclin-depe (1262) 8299 485.1 1.5e-135
XP_016880240 (OMIM: 615514) PREDICTED: cyclin-depe (1262) 8299 485.1 1.5e-135
XP_011523209 (OMIM: 615514) PREDICTED: cyclin-depe (1262) 8299 485.1 1.5e-135
XP_016880242 (OMIM: 615514) PREDICTED: cyclin-depe (1261) 8282 484.1  3e-135
XP_011523194 (OMIM: 615514) PREDICTED: cyclin-depe (1464) 6147 363.7   6e-99
NP_003709 (OMIM: 603309) cyclin-dependent kinase 1 (1512) 2928 182.1 2.8e-44
NP_112557 (OMIM: 603309) cyclin-dependent kinase 1 (1452) 2678 168.0 4.8e-40
XP_016868240 (OMIM: 603309) PREDICTED: cyclin-depe (1482) 1619 108.3 4.7e-22
XP_011513899 (OMIM: 603309) PREDICTED: cyclin-depe ( 905) 1589 106.4   1e-21
XP_016868239 (OMIM: 603309) PREDICTED: cyclin-depe (1542) 1589 106.6 1.6e-21
NP_001252 (OMIM: 603251) cyclin-dependent kinase 9 ( 372)  979 71.7 1.2e-11
XP_016870050 (OMIM: 610076) PREDICTED: cyclin-depe ( 351)  764 59.6 5.1e-08
XP_016870051 (OMIM: 610076) PREDICTED: cyclin-depe ( 329)  747 58.6 9.4e-08
NP_001250 (OMIM: 603368,616080) cyclin-dependent k ( 326)  673 54.4 1.7e-06
NP_001138778 (OMIM: 603368,616080) cyclin-dependen ( 326)  673 54.4 1.7e-06
XP_006715898 (OMIM: 603368,616080) PREDICTED: cycl ( 326)  673 54.4 1.7e-06
NP_620602 (OMIM: 602521) mitogen-activated protein ( 816)  660 54.0 5.7e-06
NP_620603 (OMIM: 602521) mitogen-activated protein ( 816)  660 54.0 5.7e-06
NP_002740 (OMIM: 602521) mitogen-activated protein ( 816)  660 54.0 5.7e-06
XP_006721621 (OMIM: 602521) PREDICTED: mitogen-act ( 822)  655 53.7   7e-06
XP_006721622 (OMIM: 602521) PREDICTED: mitogen-act ( 822)  655 53.7   7e-06
XP_006721620 (OMIM: 602521) PREDICTED: mitogen-act ( 822)  655 53.7   7e-06
NP_000066 (OMIM: 123829,609048) cyclin-dependent k ( 303)  624 51.7 1.1e-05
NP_001034892 (OMIM: 610076) cyclin-dependent kinas ( 346)  622 51.6 1.3e-05
NP_001790 (OMIM: 601955) cyclin-dependent kinase 7 ( 346)  618 51.4 1.5e-05
XP_016869673 (OMIM: 603251) PREDICTED: cyclin-depe ( 243)  610 50.8 1.6e-05


>>NP_057591 (OMIM: 615514) cyclin-dependent kinase 12 is  (1490 aa)
 initn: 9956 init1: 9956 opt: 9956  Z-score: 3058.5  bits: 578.6 E(85289): 1.3e-163
Smith-Waterman score: 9956; 99.9% identity (99.9% similar) in 1490 aa overlap (1-1490:1-1490)

               10        20        30        40        50        60
pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
NP_057 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490
pF1KE2 GELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY
       ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 GELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY
             1450      1460      1470      1480      1490

>>XP_005257513 (OMIM: 615514) PREDICTED: cyclin-dependen  (1489 aa)
 initn: 7651 init1: 7651 opt: 9939  Z-score: 3053.4  bits: 577.6 E(85289): 2.5e-163
Smith-Waterman score: 9939; 99.9% identity (99.9% similar) in 1490 aa overlap (1-1490:1-1489)

               10        20        30        40        50        60
pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
       :::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::
XP_005 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLP-RKSMKSRSRSP
              310       320       330       340        350         

              370       380       390       400       410       420
pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
     360       370       380       390       400       410         

              430       440       450       460       470       480
pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
     420       430       440       450       460       470         

              490       500       510       520       530       540
pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
     480       490       500       510       520       530         

              550       560       570       580       590       600
pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
     540       550       560       570       580       590         

              610       620       630       640       650       660
pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
     600       610       620       630       640       650         

              670       680       690       700       710       720
pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
     660       670       680       690       700       710         

              730       740       750       760       770       780
pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
     720       730       740       750       760       770         

              790       800       810       820       830       840
pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
     780       790       800       810       820       830         

              850       860       870       880       890       900
pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
     840       850       860       870       880       890         

              910       920       930       940       950       960
pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
     900       910       920       930       940       950         

              970       980       990      1000      1010      1020
pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
     960       970       980       990      1000      1010         

             1030      1040      1050      1060      1070      1080
pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
    1020      1030      1040      1050      1060      1070         

             1090      1100      1110      1120      1130      1140
pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
    1080      1090      1100      1110      1120      1130         

             1150      1160      1170      1180      1190      1200
pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
XP_005 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS
    1140      1150      1160      1170      1180      1190         

             1210      1220      1230      1240      1250      1260
pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
    1200      1210      1220      1230      1240      1250         

             1270      1280      1290      1300      1310      1320
pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
    1260      1270      1280      1290      1300      1310         

             1330      1340      1350      1360      1370      1380
pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
    1320      1330      1340      1350      1360      1370         

             1390      1400      1410      1420      1430      1440
pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY
    1380      1390      1400      1410      1420      1430         

             1450      1460      1470      1480      1490
pF1KE2 GELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY
       ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY
    1440      1450      1460      1470      1480         

>>XP_011523200 (OMIM: 615514) PREDICTED: cyclin-dependen  (1393 aa)
 initn: 9284 init1: 9284 opt: 9284  Z-score: 2854.1  bits: 540.7 E(85289): 3.1e-152
Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393)

               10        20        30        40        50        60
pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
XP_011 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY
       :::::::::::::                                               
XP_011 SHLGESSSYQGTG                                               
             1390                                                  

>>XP_011523199 (OMIM: 615514) PREDICTED: cyclin-dependen  (1393 aa)
 initn: 9284 init1: 9284 opt: 9284  Z-score: 2854.1  bits: 540.7 E(85289): 3.1e-152
Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393)

               10        20        30        40        50        60
pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
XP_011 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY
       :::::::::::::                                               
XP_011 SHLGESSSYQGTG                                               
             1390                                                  

>>XP_016880233 (OMIM: 615514) PREDICTED: cyclin-dependen  (1393 aa)
 initn: 9284 init1: 9284 opt: 9284  Z-score: 2854.1  bits: 540.7 E(85289): 3.1e-152
Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393)

               10        20        30        40        50        60
pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
XP_016 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY
       :::::::::::::                                               
XP_016 SHLGESSSYQGTG                                               
             1390                                                  

>>XP_011523198 (OMIM: 615514) PREDICTED: cyclin-dependen  (1393 aa)
 initn: 9284 init1: 9284 opt: 9284  Z-score: 2854.1  bits: 540.7 E(85289): 3.1e-152
Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393)

               10        20        30        40        50        60
pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
XP_011 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY
       :::::::::::::                                               
XP_011 SHLGESSSYQGTG                                               
             1390                                                  

>>XP_011523196 (OMIM: 615514) PREDICTED: cyclin-dependen  (1393 aa)
 initn: 9284 init1: 9284 opt: 9284  Z-score: 2854.1  bits: 540.7 E(85289): 3.1e-152
Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393)

               10        20        30        40        50        60
pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
XP_011 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY
       :::::::::::::                                               
XP_011 SHLGESSSYQGTG                                               
             1390                                                  

>>XP_011523195 (OMIM: 615514) PREDICTED: cyclin-dependen  (1393 aa)
 initn: 9284 init1: 9284 opt: 9284  Z-score: 2854.1  bits: 540.7 E(85289): 3.1e-152
Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393)

               10        20        30        40        50        60
pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
XP_011 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY
       :::::::::::::                                               
XP_011 SHLGESSSYQGTG                                               
             1390                                                  

>>XP_011523201 (OMIM: 615514) PREDICTED: cyclin-dependen  (1393 aa)
 initn: 9284 init1: 9284 opt: 9284  Z-score: 2854.1  bits: 540.7 E(85289): 3.1e-152
Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393)

               10        20        30        40        50        60
pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
XP_011 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY
       :::::::::::::                                               
XP_011 SHLGESSSYQGTG                                               
             1390                                                  

>>XP_016880234 (OMIM: 615514) PREDICTED: cyclin-dependen  (1393 aa)
 initn: 9284 init1: 9284 opt: 9284  Z-score: 2854.1  bits: 540.7 E(85289): 3.1e-152
Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393)

               10        20        30        40        50        60
pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
XP_016 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY
       :::::::::::::                                               
XP_016 SHLGESSSYQGTG                                               
             1390                                                  




1490 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 13:51:50 2016 done: Sun Nov  6 13:51:53 2016
 Total Scan time: 22.860 Total Display time:  0.640

Function used was FASTA [36.3.4 Apr, 2011]
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