FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2381, 1490 aa 1>>>pF1KE2381 1490 - 1490 aa - 1490 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 19.8588+/-0.000539; mu= -42.3378+/- 0.034 mean_var=1075.9156+/-233.164, 0's: 0 Z-trim(124.8): 420 B-trim: 2752 in 1/61 Lambda= 0.039101 statistics sampled from 46709 (47209) to 46709 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.787), E-opt: 0.2 (0.554), width: 16 Scan time: 22.860 The best scores are: opt bits E(85289) NP_057591 (OMIM: 615514) cyclin-dependent kinase 1 (1490) 9956 578.6 1.3e-163 XP_005257513 (OMIM: 615514) PREDICTED: cyclin-depe (1489) 9939 577.6 2.5e-163 XP_011523200 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_011523199 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_016880233 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_011523198 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_011523196 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_011523195 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_011523201 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_016880234 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_016880238 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_011523208 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_016880237 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_016880236 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_011523204 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_011523203 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_011523202 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_016880235 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_011523197 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_011523205 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 XP_011523207 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 9284 540.7 3.1e-152 NP_055898 (OMIM: 615514) cyclin-dependent kinase 1 (1481) 8393 490.4 4.4e-137 XP_005257515 (OMIM: 615514) PREDICTED: cyclin-depe (1256) 8299 485.1 1.5e-135 XP_016880239 (OMIM: 615514) PREDICTED: cyclin-depe (1262) 8299 485.1 1.5e-135 XP_016880241 (OMIM: 615514) PREDICTED: cyclin-depe (1262) 8299 485.1 1.5e-135 XP_016880240 (OMIM: 615514) PREDICTED: cyclin-depe (1262) 8299 485.1 1.5e-135 XP_011523209 (OMIM: 615514) PREDICTED: cyclin-depe (1262) 8299 485.1 1.5e-135 XP_016880242 (OMIM: 615514) PREDICTED: cyclin-depe (1261) 8282 484.1 3e-135 XP_011523194 (OMIM: 615514) PREDICTED: cyclin-depe (1464) 6147 363.7 6e-99 NP_003709 (OMIM: 603309) cyclin-dependent kinase 1 (1512) 2928 182.1 2.8e-44 NP_112557 (OMIM: 603309) cyclin-dependent kinase 1 (1452) 2678 168.0 4.8e-40 XP_016868240 (OMIM: 603309) PREDICTED: cyclin-depe (1482) 1619 108.3 4.7e-22 XP_011513899 (OMIM: 603309) PREDICTED: cyclin-depe ( 905) 1589 106.4 1e-21 XP_016868239 (OMIM: 603309) PREDICTED: cyclin-depe (1542) 1589 106.6 1.6e-21 NP_001252 (OMIM: 603251) cyclin-dependent kinase 9 ( 372) 979 71.7 1.2e-11 XP_016870050 (OMIM: 610076) PREDICTED: cyclin-depe ( 351) 764 59.6 5.1e-08 XP_016870051 (OMIM: 610076) PREDICTED: cyclin-depe ( 329) 747 58.6 9.4e-08 NP_001250 (OMIM: 603368,616080) cyclin-dependent k ( 326) 673 54.4 1.7e-06 NP_001138778 (OMIM: 603368,616080) cyclin-dependen ( 326) 673 54.4 1.7e-06 XP_006715898 (OMIM: 603368,616080) PREDICTED: cycl ( 326) 673 54.4 1.7e-06 NP_620602 (OMIM: 602521) mitogen-activated protein ( 816) 660 54.0 5.7e-06 NP_620603 (OMIM: 602521) mitogen-activated protein ( 816) 660 54.0 5.7e-06 NP_002740 (OMIM: 602521) mitogen-activated protein ( 816) 660 54.0 5.7e-06 XP_006721621 (OMIM: 602521) PREDICTED: mitogen-act ( 822) 655 53.7 7e-06 XP_006721622 (OMIM: 602521) PREDICTED: mitogen-act ( 822) 655 53.7 7e-06 XP_006721620 (OMIM: 602521) PREDICTED: mitogen-act ( 822) 655 53.7 7e-06 NP_000066 (OMIM: 123829,609048) cyclin-dependent k ( 303) 624 51.7 1.1e-05 NP_001034892 (OMIM: 610076) cyclin-dependent kinas ( 346) 622 51.6 1.3e-05 NP_001790 (OMIM: 601955) cyclin-dependent kinase 7 ( 346) 618 51.4 1.5e-05 XP_016869673 (OMIM: 603251) PREDICTED: cyclin-depe ( 243) 610 50.8 1.6e-05 >>NP_057591 (OMIM: 615514) cyclin-dependent kinase 12 is (1490 aa) initn: 9956 init1: 9956 opt: 9956 Z-score: 3058.5 bits: 578.6 E(85289): 1.3e-163 Smith-Waterman score: 9956; 99.9% identity (99.9% similar) in 1490 aa overlap (1-1490:1-1490) 10 20 30 40 50 60 pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: NP_057 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 pF1KE2 GELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY :::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY 1450 1460 1470 1480 1490 >>XP_005257513 (OMIM: 615514) PREDICTED: cyclin-dependen (1489 aa) initn: 7651 init1: 7651 opt: 9939 Z-score: 3053.4 bits: 577.6 E(85289): 2.5e-163 Smith-Waterman score: 9939; 99.9% identity (99.9% similar) in 1490 aa overlap (1-1490:1-1489) 10 20 30 40 50 60 pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_005 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLP-RKSMKSRSRSP 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG 660 670 680 690 700 710 730 740 750 760 770 780 pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ 720 730 740 750 760 770 790 800 810 820 830 840 pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM 780 790 800 810 820 830 850 860 870 880 890 900 pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW 840 850 860 870 880 890 910 920 930 940 950 960 pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: XP_005 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL 1200 1210 1220 1230 1240 1250 1270 1280 1290 1300 1310 1320 pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH 1260 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 1380 pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL 1320 1330 1340 1350 1360 1370 1390 1400 1410 1420 1430 1440 pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY 1380 1390 1400 1410 1420 1430 1450 1460 1470 1480 1490 pF1KE2 GELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY 1440 1450 1460 1470 1480 >>XP_011523200 (OMIM: 615514) PREDICTED: cyclin-dependen (1393 aa) initn: 9284 init1: 9284 opt: 9284 Z-score: 2854.1 bits: 540.7 E(85289): 3.1e-152 Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393) 10 20 30 40 50 60 pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: XP_011 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY ::::::::::::: XP_011 SHLGESSSYQGTG 1390 >>XP_011523199 (OMIM: 615514) PREDICTED: cyclin-dependen (1393 aa) initn: 9284 init1: 9284 opt: 9284 Z-score: 2854.1 bits: 540.7 E(85289): 3.1e-152 Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393) 10 20 30 40 50 60 pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: XP_011 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY ::::::::::::: XP_011 SHLGESSSYQGTG 1390 >>XP_016880233 (OMIM: 615514) PREDICTED: cyclin-dependen (1393 aa) initn: 9284 init1: 9284 opt: 9284 Z-score: 2854.1 bits: 540.7 E(85289): 3.1e-152 Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393) 10 20 30 40 50 60 pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: XP_016 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY ::::::::::::: XP_016 SHLGESSSYQGTG 1390 >>XP_011523198 (OMIM: 615514) PREDICTED: cyclin-dependen (1393 aa) initn: 9284 init1: 9284 opt: 9284 Z-score: 2854.1 bits: 540.7 E(85289): 3.1e-152 Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393) 10 20 30 40 50 60 pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: XP_011 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY ::::::::::::: XP_011 SHLGESSSYQGTG 1390 >>XP_011523196 (OMIM: 615514) PREDICTED: cyclin-dependen (1393 aa) initn: 9284 init1: 9284 opt: 9284 Z-score: 2854.1 bits: 540.7 E(85289): 3.1e-152 Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393) 10 20 30 40 50 60 pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: XP_011 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY ::::::::::::: XP_011 SHLGESSSYQGTG 1390 >>XP_011523195 (OMIM: 615514) PREDICTED: cyclin-dependen (1393 aa) initn: 9284 init1: 9284 opt: 9284 Z-score: 2854.1 bits: 540.7 E(85289): 3.1e-152 Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393) 10 20 30 40 50 60 pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: XP_011 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY ::::::::::::: XP_011 SHLGESSSYQGTG 1390 >>XP_011523201 (OMIM: 615514) PREDICTED: cyclin-dependen (1393 aa) initn: 9284 init1: 9284 opt: 9284 Z-score: 2854.1 bits: 540.7 E(85289): 3.1e-152 Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393) 10 20 30 40 50 60 pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: XP_011 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY ::::::::::::: XP_011 SHLGESSSYQGTG 1390 >>XP_016880234 (OMIM: 615514) PREDICTED: cyclin-dependen (1393 aa) initn: 9284 init1: 9284 opt: 9284 Z-score: 2854.1 bits: 540.7 E(85289): 3.1e-152 Smith-Waterman score: 9284; 99.9% identity (99.9% similar) in 1393 aa overlap (1-1393:1-1393) 10 20 30 40 50 60 pF1KE2 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQMTLEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: XP_016 HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY ::::::::::::: XP_016 SHLGESSSYQGTG 1390 1490 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 13:51:50 2016 done: Sun Nov 6 13:51:53 2016 Total Scan time: 22.860 Total Display time: 0.640 Function used was FASTA [36.3.4 Apr, 2011]