Result of FASTA (omim) for
pF1KE2391
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2391, 517 aa
1>>>pF1KE2391 517 - 517 aa - 517 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8820+/-0.000307; mu= 21.0582+/- 0.019
mean_var=62.9781+/-12.471, 0's: 0 Z-trim(116.3): 168 B-trim: 15 in 1/52
Lambda= 0.161614
statistics sampled from 27145 (27315) to 27145 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.677), E-opt: 0.2 (0.32), width: 16
Scan time: 10.130
The best scores are: opt bits E(85289)
NP_000742 (OMIM: 100720,253290,616321,616322,61632 ( 517) 3452 813.3 0
NP_001243586 (OMIM: 100720,253290,616321,616322,61 ( 502) 2953 697.0 3.4e-200
NP_001298125 (OMIM: 100720,253290,616321,616322,61 ( 416) 2670 631.0 2.1e-180
XP_011508826 (OMIM: 100720,253290,616321,616322,61 ( 390) 2053 487.1 4.1e-137
NP_001298124 (OMIM: 100720,253290,616321,616322,61 ( 323) 1593 379.8 6.8e-105
NP_005190 (OMIM: 100730,253290,265000) acetylcholi ( 517) 1547 369.2 1.7e-101
NP_000071 (OMIM: 100725,605809,608931,616324) acet ( 493) 1308 313.4 9.6e-85
XP_016879604 (OMIM: 100725,605809,608931,616324) P ( 481) 1296 310.6 6.5e-84
NP_000738 (OMIM: 100710,616313,616314) acetylcholi ( 501) 1268 304.1 6.2e-82
XP_016855669 (OMIM: 118507,605375) PREDICTED: neur ( 332) 726 177.6 5e-44
XP_011519493 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 713 174.7 4.9e-43
XP_011519492 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 713 174.7 4.9e-43
XP_016877374 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 713 174.7 5.3e-43
XP_016877375 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 713 174.7 5.3e-43
XP_011519494 (OMIM: 118509) PREDICTED: neuronal ac ( 316) 699 171.3 3.8e-42
NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479) 670 164.7 5.7e-40
NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494) 670 164.7 5.8e-40
NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502) 623 153.7 1.2e-36
XP_006716345 (OMIM: 118502,610353) PREDICTED: neur ( 529) 619 152.8 2.3e-36
XP_011542690 (OMIM: 118502,610353) PREDICTED: neur ( 529) 619 152.8 2.3e-36
NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529) 619 152.8 2.3e-36
XP_016877378 (OMIM: 118509) PREDICTED: neuronal ac ( 449) 564 139.9 1.5e-32
XP_016877377 (OMIM: 118509) PREDICTED: neuronal ac ( 462) 564 139.9 1.5e-32
XP_016877376 (OMIM: 118509) PREDICTED: neuronal ac ( 463) 564 140.0 1.5e-32
NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498) 564 140.0 1.6e-32
XP_006720445 (OMIM: 118503,612052) PREDICTED: neur ( 438) 562 139.5 2e-32
NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 562 139.5 2.2e-32
NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 562 139.5 2.2e-32
XP_011519488 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 549 136.5 1.8e-31
XP_011519489 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 549 136.5 1.8e-31
NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458) 546 135.7 2.8e-31
NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 534 133.0 1.9e-30
XP_016858746 (OMIM: 100690,253290,601462,608930) P ( 464) 534 133.0 1.9e-30
NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482) 534 133.0 2e-30
XP_016858745 (OMIM: 100690,253290,601462,608930) P ( 489) 534 133.0 2e-30
XP_016883114 (OMIM: 118504,188890,600513) PREDICTE ( 451) 530 132.0 3.6e-30
NP_001243502 (OMIM: 118504,188890,600513) neuronal ( 451) 530 132.0 3.6e-30
XP_016883113 (OMIM: 118504,188890,600513) PREDICTE ( 546) 530 132.1 4.2e-30
XP_011526826 (OMIM: 118504,188890,600513) PREDICTE ( 556) 530 132.1 4.3e-30
NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627) 530 132.1 4.7e-30
XP_005254199 (OMIM: 118505,612052) PREDICTED: neur ( 243) 522 130.0 8.1e-30
XP_016877370 (OMIM: 118505,612052) PREDICTED: neur ( 245) 522 130.0 8.1e-30
XP_016868492 (OMIM: 118502,610353) PREDICTED: neur ( 370) 524 130.6 8.2e-30
XP_005273454 (OMIM: 118502,610353) PREDICTED: neur ( 370) 524 130.6 8.2e-30
NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514) 524 130.7 1.1e-29
XP_016868493 (OMIM: 118502,610353) PREDICTED: neur ( 331) 520 129.6 1.4e-29
XP_011542691 (OMIM: 118502,610353) PREDICTED: neur ( 331) 520 129.6 1.4e-29
XP_011542692 (OMIM: 118508) PREDICTED: neuronal ac ( 329) 469 117.7 5.4e-26
XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380) 459 115.4 3e-25
NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502) 459 115.5 3.8e-25
>>NP_000742 (OMIM: 100720,253290,616321,616322,616323) a (517 aa)
initn: 3452 init1: 3452 opt: 3452 Z-score: 4343.8 bits: 813.3 E(85289): 0
Smith-Waterman score: 3452; 100.0% identity (100.0% similar) in 517 aa overlap (1-517:1-517)
10 20 30 40 50 60
pF1KE2 MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 ATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 MSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 PASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPV
430 440 450 460 470 480
490 500 510
pF1KE2 MVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
:::::::::::::::::::::::::::::::::::::
NP_000 MVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
490 500 510
>>NP_001243586 (OMIM: 100720,253290,616321,616322,616323 (502 aa)
initn: 2945 init1: 2945 opt: 2953 Z-score: 3715.2 bits: 697.0 E(85289): 3.4e-200
Smith-Waterman score: 3315; 97.1% identity (97.1% similar) in 517 aa overlap (1-517:1-502)
10 20 30 40 50 60
pF1KE2 MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND
:::::: :::::::::::::::::::::::::::::::::::::::
NP_001 SNLISL---------------GWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND
70 80 90 100
130 140 150 160 170 180
pF1KE2 GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE2 LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE2 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLP
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE2 ATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE2 MSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRP
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE2 PASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPV
410 420 430 440 450 460
490 500 510
pF1KE2 MVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
:::::::::::::::::::::::::::::::::::::
NP_001 MVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
470 480 490 500
>>NP_001298125 (OMIM: 100720,253290,616321,616322,616323 (416 aa)
initn: 2670 init1: 2670 opt: 2670 Z-score: 3359.7 bits: 631.0 E(85289): 2.1e-180
Smith-Waterman score: 2670; 100.0% identity (100.0% similar) in 399 aa overlap (119-517:18-416)
90 100 110 120 130 140
pF1KE2 KWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFR
::::::::::::::::::::::::::::::
NP_001 MLKNLETSVSCASPRTCNDGSFQISYSCNVLVYHYGFVYWLPPAIFR
10 20 30 40
150 160 170 180 190 200
pF1KE2 SSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTEN
50 60 70 80 90 100
210 220 230 240 250 260
pF1KE2 GEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVF
110 120 130 140 150 160
270 280 290 300 310 320
pF1KE2 YLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICV
170 180 190 200 210 220
330 340 350 360 370 380
pF1KE2 IVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAE
230 240 250 260 270 280
390 400 410 420 430 440
pF1KE2 EYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNH
290 300 310 320 330 340
450 460 470 480 490 500
pF1KE2 MRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYS
350 360 370 380 390 400
510
pF1KE2 YNVQDKRFI
:::::::::
NP_001 YNVQDKRFI
410
>>XP_011508826 (OMIM: 100720,253290,616321,616322,616323 (390 aa)
initn: 2053 init1: 2053 opt: 2053 Z-score: 2582.6 bits: 487.1 E(85289): 4.1e-137
Smith-Waterman score: 2053; 99.7% identity (100.0% similar) in 312 aa overlap (206-517:79-390)
180 190 200 210 220 230
pF1KE2 AKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQD
.:::::::::::::::::::::::::::::
XP_011 CTGCHLPSSAPPAPSLSPISPSTGRTAPSSSENGEWEIVHRPARVNVDPRAPLDSPSRQD
50 60 70 80 90 100
240 250 260 270 280 290
pF1KE2 ITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLI
110 120 130 140 150 160
300 310 320 330 340 350
pF1KE2 SKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETL
170 180 190 200 210 220
360 370 380 390 400 410
pF1KE2 PELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLT
230 240 250 260 270 280
420 430 440 450 460 470
pF1KE2 TARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLF
290 300 310 320 330 340
480 490 500 510
pF1KE2 VVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
::::::::::::::::::::::::::::::::::::::::::
XP_011 VVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
350 360 370 380 390
>>NP_001298124 (OMIM: 100720,253290,616321,616322,616323 (323 aa)
initn: 1590 init1: 1590 opt: 1593 Z-score: 2004.1 bits: 379.8 E(85289): 6.8e-105
Smith-Waterman score: 1593; 98.8% identity (99.6% similar) in 248 aa overlap (271-517:76-323)
250 260 270 280 290
pF1KE2 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSG-EKTSVAISVLLAQSVFLLLISKRL
:..:: ::::::::::::::::::::::::
NP_001 TASCTGCHLPSSAPPAPSLSPISPSTGRTAPSSSGGEKTSVAISVLLAQSVFLLLISKRL
50 60 70 80 90 100
300 310 320 330 340 350
pF1KE2 PATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELL
110 120 130 140 150 160
360 370 380 390 400 410
pF1KE2 HMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARR
170 180 190 200 210 220
420 430 440 450 460 470
pF1KE2 PPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTP
230 240 250 260 270 280
480 490 500 510
pF1KE2 VMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
::::::::::::::::::::::::::::::::::::::
NP_001 VMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
290 300 310 320
>>NP_005190 (OMIM: 100730,253290,265000) acetylcholine r (517 aa)
initn: 1119 init1: 617 opt: 1547 Z-score: 1943.3 bits: 369.2 E(85289): 1.7e-101
Smith-Waterman score: 1547; 48.2% identity (74.9% similar) in 521 aa overlap (2-509:5-512)
10 20 30 40 50
pF1KE2 MEGPVLTLGLLAALAVC-GSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVAL
.::.: :: :::: :. : :.::::. :.: .:. .:::. . . :.:.:
NP_005 MHGGQGPLL---LLLLLAVCLGAQGRNQEERLLADLMQ--NYDPNLRPAERDSDVVNVSL
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 ALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLE
:::.:::::.: ::.:::::::: : : ::.:. ... .. :::.: ::: :.::::
NP_005 KLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 NNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTA
:: :: :... ::::: : .::::::::::.: ::::::::::::::: :.: :..
NP_005 NNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYST
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 KEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDI
.:: :.:.:. ...: .:::.::::.::::::: : ::::.. .:: :: . ..: .
NP_005 NEIDLQLSQE--DGQT--IEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKV
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 TFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSG-EKTSVAISVLLAQSVFLLLI
.:::.:.::::::.:::..:::::: .. :. .::: .: .: .:::.:::::.:::.:.
NP_005 VFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLV
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 SKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETL
.:..: ::.:.:::.:.: : .:.. ..:: :.:::. .:.: :: ...::.:.::. :
NP_005 AKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLL
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE2 PELLHMS-RPAEDGPSPGALVR-RSSSLGY-ISKAEEYFLLKSRSDLMFEKQSERHGL-A
:.::.: :: . . : ...: :. :. .:: : ::.:.:. : .:.:: :
NP_005 PQLLRMHVRPLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQ-QWQRQGLVA
360 370 380 390 400 410
420 430 440 450 460
pF1KE2 RRLTTARRPPASSEQAQQELFNELK---PA----VDGANFIVNHMRDQNNYNEEKDSWNR
: .. : : . ... . :: :: :.. :.:. ..:..... .. :
NP_005 AALEKLEKGP---ELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFL
420 430 440 450 460
470 480 490 500 510
pF1KE2 VARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
:.:..::.:.... ... ::: :::.. ::. : :::::: :
NP_005 VGRVLDRVCFLAMLSLFICGTAGIFLMAHYNRVPALPFPGDPRPYLPSPD
470 480 490 500 510
>>NP_000071 (OMIM: 100725,605809,608931,616324) acetylch (493 aa)
initn: 1424 init1: 582 opt: 1308 Z-score: 1642.4 bits: 313.4 E(85289): 9.6e-85
Smith-Waterman score: 1432; 46.1% identity (73.8% similar) in 497 aa overlap (8-502:6-487)
10 20 30 40 50
pF1KE2 MEGPVLTLGLLAALAVCG-SWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALT
::.: :.. : . : ::: :: .:::.. :. ::: . :..: ..: .:
NP_000 MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNN--YDPGSRPVREPEDTVTISLKVT
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 LSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNN
:.:::::.: ::::::.::: : : ::... ..::.: .::.: ..:::::::::::
NP_000 LTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 DGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEI
::.: ..:. :::::. : : ::::::.:: : . ::::::::::::: : : :.:.:.
NP_000 DGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 TLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFY
... : ....: .. : :: :..:::::: : :. . . :.:.. :. .
NP_000 EFTFAVD-NDGKT--INKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 LIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSG-EKTSVAISVLLAQSVFLLLISKR
::::::::::.:::.::::::: .: :...:::..: .: .:.:.:::::.:::.::...
NP_000 LIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQK
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 LPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPEL
.: ::...::.:.::.: ::..:..:. ::::::. :::.::..: .....:: ::.:
NP_000 IPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRL
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE2 LHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTAR
: : : ..: .. ::.::.: . .::: .: : ::.:.:: : .:.:
NP_000 LG-SPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWT------
360 370 380 390 400
420 430 440 450 460 470
pF1KE2 RPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVT
:. :. :.. ::..::... :::. .:: ..: :.. ..: .:....
NP_000 ---AAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAAL
410 420 430 440 450 460
480 490 500 510
pF1KE2 PVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
.. ::.. ::: . .:. : :.
NP_000 VLFSVGSSLIFLGAYFNRVPDLPYAPCIQP
470 480 490
>>XP_016879604 (OMIM: 100725,605809,608931,616324) PREDI (481 aa)
initn: 1424 init1: 582 opt: 1296 Z-score: 1627.4 bits: 310.6 E(85289): 6.5e-84
Smith-Waterman score: 1420; 46.4% identity (74.1% similar) in 483 aa overlap (21-502:8-475)
10 20 30 40 50 60
pF1KE2 MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL
: ::: :: .:::.. :. ::: . :..: ..: .::
XP_016 MQRGRGVGKNEELRLYHHLFNN--YDPGSRPVREPEDTVTISLKVTL
10 20 30 40
70 80 90 100 110 120
pF1KE2 SNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND
.:::::.: ::::::.::: : : ::... ..::.: .::.: ..::::::::::: :
XP_016 TNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNID
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE2 GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT
:.: ..:. :::::. : : ::::::.:: : . ::::::::::::: : : :.:.:.
XP_016 GQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVE
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE2 LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL
... : ....: .. : :: :..:::::: : :. . . :.:.. :. . :
XP_016 FTFAVD-NDGKT--INKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSL
170 180 190 200 210 220
250 260 270 280 290
pF1KE2 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSG-EKTSVAISVLLAQSVFLLLISKRL
:::::::::.:::.::::::: .: :...:::..: .: .:.:.:::::.:::.::....
XP_016 IIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKI
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE2 PATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELL
: ::...::.:.::.: ::..:..:. ::::::. :::.::..: .....:: ::.::
XP_016 PETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLL
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE2 HMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARR
: : ..: .. ::.::.: . .::: .: : ::.:.:: : .:.:
XP_016 G-SPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWT-------
350 360 370 380 390
420 430 440 450 460 470
pF1KE2 PPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTP
:. :. :.. ::..::... :::. .:: ..: :.. ..: .:....
XP_016 --AAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALV
400 410 420 430 440 450
480 490 500 510
pF1KE2 VMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
.. ::.. ::: . .:. : :.
XP_016 LFSVGSSLIFLGAYFNRVPDLPYAPCIQP
460 470 480
>>NP_000738 (OMIM: 100710,616313,616314) acetylcholine r (501 aa)
initn: 1214 init1: 491 opt: 1268 Z-score: 1591.9 bits: 304.1 E(85289): 6.2e-82
Smith-Waterman score: 1268; 40.4% identity (70.0% similar) in 507 aa overlap (5-503:7-501)
10 20 30 40 50
pF1KE2 MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALAL
.. :: :.: . : : . : :: ..:: .::.. .::. . . : :...:
NP_000 MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLF--SGYDSSVRPAREVGDRVRVSVGL
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 TLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENN
:..::::.: .: ..:.:... ::: ::.:. : .:. ::. . ::::..:: ::
NP_000 ILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 NDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKE
:::.:... . .:.: : : : ::.:.:::: :.:::::::::::.. ::: .: ..:
NP_000 NDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 ITLS--LKQDAKENRTYPVEWIIIDPEG-FTENGEWEIVHRPARVNVDPRAPLDS--PSR
..:. : :.. .. .. :: : :::.:::.:.:.:. : : . .:
NP_000 VSLQTGLGPDGQGHQEIHIH------EGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQR
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 QDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLL
:.. ::::::::::::..:...::.::.... .::::: :.::: ...: .::. .::::
NP_000 QEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 LISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLE
:.. ..: ::...:.: :.:.: :::::. :.. :.:::.: :.: :: . :...:..
NP_000 LLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIH
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE2 TLPELLHMSRPAEDG---PSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGL
:: :...:: . : : : . :. ..:::. : ::..: : . :
NP_000 KLPLYLRLKRPKPERDLMPEPPHC--SSPGSGWGRGTDEYFIRKPPSDFLFPKPN-RFQP
360 370 380 390 400
420 430 440 450 460 470
pF1KE2 ARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVD
:: . ..: :. ::. .:.. ..:. ....:.... :..:. :: .::
NP_000 ELSAPDLRRFIDGPNRAVA-LLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVD
410 420 430 440 450 460
480 490 500 510
pF1KE2 RLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
:: :.. ::: :::...:. :::.:::
NP_000 RLFLWTFIIFTSVGTLVIFLDATYHLPPPDPFP
470 480 490 500
>>XP_016855669 (OMIM: 118507,605375) PREDICTED: neuronal (332 aa)
initn: 776 init1: 527 opt: 726 Z-score: 911.5 bits: 177.6 E(85289): 5e-44
Smith-Waterman score: 739; 39.9% identity (63.6% similar) in 338 aa overlap (167-502:1-321)
140 150 160 170 180 190
pF1KE2 GFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVE
.:: : : :: : ::..
XP_016 MKFRSWTYDRTEIDLVLKSE----------
10 20
200 210 220 230 240 250
pF1KE2 WIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVP
. . . :: .:::.:: :.: : .: :. . :::. .::::::::: ::...:
XP_016 --VASLDDFTPSGEWDIVALPGRRNENP----DDSTYVDITYDFIIRRKPLFYTINLIIP
30 40 50 60 70
260 270 280 290 300 310
pF1KE2 CVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFG
::::. .. ::::::.: ::: .. :::::: .:::::::: .: ::. .::.::.:.:
XP_016 CVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFT
80 90 100 110 120 130
320 330 340 350 360 370
pF1KE2 MVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVR
:::::. .: : :::.: :.:.::... :: .::: :: :: :..: . .:
XP_016 MVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLR
140 150 160 170 180 190
380 390 400 410 420 430
pF1KE2 RSSSLGYISKAEEYFLLKSRSD--LMFEKQSERHGLARRLTTARRPPASSEQAQQELFNE
: . . : .: .: : ... .::: . . : :. .. .
XP_016 RRQREREGAGAL-FFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCG
200 210 220 230 240 250
440 450 460 470 480 490
pF1KE2 LKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVY
:. ::::. ::..:::.... . ...:. :: ..::: :.. . : : :: .::: ..
XP_016 LREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLF
260 270 280 290 300 310
500 510
pF1KE2 NQPPPQPFPGDPYSYNVQDKRFI
.. :
XP_016 QNYTTTTFLHSDHSAPSSK
320 330
517 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 09:29:37 2016 done: Sun Nov 6 09:29:39 2016
Total Scan time: 10.130 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]