FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2393, 498 aa 1>>>pF1KE2393 498 - 498 aa - 498 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.6205+/-0.000374; mu= 11.5745+/- 0.023 mean_var=94.4857+/-18.720, 0's: 0 Z-trim(114.9): 167 B-trim: 0 in 0/52 Lambda= 0.131944 statistics sampled from 24775 (24947) to 24775 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.656), E-opt: 0.2 (0.292), width: 16 Scan time: 9.710 The best scores are: opt bits E(85289) NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498) 3350 648.2 1.6e-185 XP_011519489 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 3222 623.8 3.4e-178 XP_011519488 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 3222 623.8 3.4e-178 XP_016877375 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 3150 610.1 4.3e-174 XP_016877374 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 3150 610.1 4.3e-174 XP_016877377 (OMIM: 118509) PREDICTED: neuronal ac ( 462) 2994 580.4 3.7e-165 XP_016877376 (OMIM: 118509) PREDICTED: neuronal ac ( 463) 2993 580.2 4.3e-165 XP_016877378 (OMIM: 118509) PREDICTED: neuronal ac ( 449) 2988 579.3 8.1e-165 XP_011519493 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 2888 560.2 4.1e-159 XP_011519492 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 2888 560.2 4.1e-159 XP_011519494 (OMIM: 118509) PREDICTED: neuronal ac ( 316) 2135 416.8 4.5e-116 NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502) 2080 406.4 9.5e-113 NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494) 1460 288.4 3.2e-77 XP_016855669 (OMIM: 118507,605375) PREDICTED: neur ( 332) 1368 270.8 4.2e-72 NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479) 1317 261.2 4.8e-69 NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 1292 256.4 1.3e-67 NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 1292 256.4 1.4e-67 NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627) 1284 255.0 4.7e-67 NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529) 1281 254.4 6.1e-67 XP_006716345 (OMIM: 118502,610353) PREDICTED: neur ( 529) 1281 254.4 6.1e-67 XP_011542690 (OMIM: 118502,610353) PREDICTED: neur ( 529) 1281 254.4 6.1e-67 XP_006720445 (OMIM: 118503,612052) PREDICTED: neur ( 438) 1207 240.2 9e-63 NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514) 1201 239.1 2.3e-62 NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458) 1190 237.0 8.8e-62 XP_016883113 (OMIM: 118504,188890,600513) PREDICTE ( 546) 1159 231.1 6.1e-60 NP_000736 (OMIM: 118505,612052) neuronal acetylcho ( 468) 1151 229.6 1.5e-59 NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 1116 222.9 1.5e-57 XP_016858746 (OMIM: 100690,253290,601462,608930) P ( 464) 1093 218.5 3.2e-56 NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502) 1052 210.8 7.7e-54 NP_001177384 (OMIM: 118511,612001) neuronal acetyl ( 531) 1052 210.8 8.1e-54 XP_011519478 (OMIM: 118511,612001) PREDICTED: neur ( 486) 970 195.1 3.7e-49 NP_060051 (OMIM: 605116) neuronal acetylcholine re ( 479) 964 194.0 8.1e-49 NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482) 964 194.0 8.2e-49 XP_016858745 (OMIM: 100690,253290,601462,608930) P ( 489) 964 194.0 8.3e-49 NP_065135 (OMIM: 606372) neuronal acetylcholine re ( 450) 953 191.9 3.3e-48 XP_011526826 (OMIM: 118504,188890,600513) PREDICTE ( 556) 931 187.7 7.2e-47 XP_005273454 (OMIM: 118502,610353) PREDICTED: neur ( 370) 919 185.4 2.5e-46 XP_016868492 (OMIM: 118502,610353) PREDICTED: neur ( 370) 919 185.4 2.5e-46 XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380) 876 177.2 7.3e-44 XP_011542692 (OMIM: 118508) PREDICTED: neuronal ac ( 329) 837 169.7 1.1e-41 NP_001243496 (OMIM: 118509) neuronal acetylcholine ( 231) 780 158.8 1.5e-38 NP_000738 (OMIM: 100710,616313,616314) acetylcholi ( 501) 777 158.4 4.4e-38 NP_001243586 (OMIM: 100720,253290,616321,616322,61 ( 502) 765 156.1 2.1e-37 XP_011519479 (OMIM: 118511,612001) PREDICTED: neur ( 401) 754 154.0 7.5e-37 XP_016877372 (OMIM: 118511,612001) PREDICTED: neur ( 440) 750 153.2 1.4e-36 XP_016877371 (OMIM: 118511,612001) PREDICTED: neur ( 441) 750 153.2 1.4e-36 NP_647536 (OMIM: 609756) CHRNA7-FAM7A fusion prote ( 412) 749 153.0 1.5e-36 XP_011520455 (OMIM: 609756) PREDICTED: CHRNA7-FAM7 ( 412) 749 153.0 1.5e-36 XP_016868493 (OMIM: 118502,610353) PREDICTED: neur ( 331) 741 151.5 3.5e-36 XP_011542691 (OMIM: 118502,610353) PREDICTED: neur ( 331) 741 151.5 3.5e-36 >>NP_000741 (OMIM: 118509) neuronal acetylcholine recept (498 aa) initn: 3350 init1: 3350 opt: 3350 Z-score: 3451.7 bits: 648.2 E(85289): 1.6e-185 Smith-Waterman score: 3350; 100.0% identity (100.0% similar) in 498 aa overlap (1-498:1-498) 10 20 30 40 50 60 pF1KE2 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP 430 440 450 460 470 480 490 pF1KE2 PLFQTHAASEGPYAAQRD :::::::::::::::::: NP_000 PLFQTHAASEGPYAAQRD 490 >>XP_011519489 (OMIM: 118509) PREDICTED: neuronal acetyl (495 aa) initn: 3222 init1: 3222 opt: 3222 Z-score: 3320.1 bits: 623.8 E(85289): 3.4e-178 Smith-Waterman score: 3222; 100.0% identity (100.0% similar) in 479 aa overlap (20-498:17-495) 10 20 30 40 50 60 pF1KE2 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL ::::::::::::::::::::::::::::::::::::::::: XP_011 MGGSLLAPAPDHIVLWNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE2 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE2 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP 420 430 440 450 460 470 490 pF1KE2 PLFQTHAASEGPYAAQRD :::::::::::::::::: XP_011 PLFQTHAASEGPYAAQRD 480 490 >>XP_011519488 (OMIM: 118509) PREDICTED: neuronal acetyl (495 aa) initn: 3222 init1: 3222 opt: 3222 Z-score: 3320.1 bits: 623.8 E(85289): 3.4e-178 Smith-Waterman score: 3222; 100.0% identity (100.0% similar) in 479 aa overlap (20-498:17-495) 10 20 30 40 50 60 pF1KE2 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL ::::::::::::::::::::::::::::::::::::::::: XP_011 MGGSLLAPAPDHIVLWNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE2 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE2 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP 420 430 440 450 460 470 490 pF1KE2 PLFQTHAASEGPYAAQRD :::::::::::::::::: XP_011 PLFQTHAASEGPYAAQRD 480 490 >>XP_016877375 (OMIM: 118509) PREDICTED: neuronal acetyl (468 aa) initn: 3150 init1: 3150 opt: 3150 Z-score: 3246.4 bits: 610.1 E(85289): 4.3e-174 Smith-Waterman score: 3150; 100.0% identity (100.0% similar) in 468 aa overlap (31-498:1-468) 10 20 30 40 50 60 pF1KE2 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL :::::::::::::::::::::::::::::: XP_016 MDDLLNKTRYNNLIRPATSSSQLISIKLQL 10 20 30 70 80 90 100 110 120 pF1KE2 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE2 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE2 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE2 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP 400 410 420 430 440 450 490 pF1KE2 PLFQTHAASEGPYAAQRD :::::::::::::::::: XP_016 PLFQTHAASEGPYAAQRD 460 >>XP_016877374 (OMIM: 118509) PREDICTED: neuronal acetyl (468 aa) initn: 3150 init1: 3150 opt: 3150 Z-score: 3246.4 bits: 610.1 E(85289): 4.3e-174 Smith-Waterman score: 3150; 100.0% identity (100.0% similar) in 468 aa overlap (31-498:1-468) 10 20 30 40 50 60 pF1KE2 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL :::::::::::::::::::::::::::::: XP_016 MDDLLNKTRYNNLIRPATSSSQLISIKLQL 10 20 30 70 80 90 100 110 120 pF1KE2 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE2 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE2 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE2 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP 400 410 420 430 440 450 490 pF1KE2 PLFQTHAASEGPYAAQRD :::::::::::::::::: XP_016 PLFQTHAASEGPYAAQRD 460 >>XP_016877377 (OMIM: 118509) PREDICTED: neuronal acetyl (462 aa) initn: 2994 init1: 2994 opt: 2994 Z-score: 3086.0 bits: 580.4 E(85289): 3.7e-165 Smith-Waterman score: 2994; 99.8% identity (100.0% similar) in 448 aa overlap (1-448:1-448) 10 20 30 40 50 60 pF1KE2 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP :::::::::::::::::::::::::::. XP_016 RQDVQEALEGVSFIAQHMKNDDEDQSVMPACQNKHPWCWRKP 430 440 450 460 >>XP_016877376 (OMIM: 118509) PREDICTED: neuronal acetyl (463 aa) initn: 2993 init1: 2993 opt: 2993 Z-score: 3085.0 bits: 580.2 E(85289): 4.3e-165 Smith-Waterman score: 2993; 100.0% identity (100.0% similar) in 447 aa overlap (1-447:1-447) 10 20 30 40 50 60 pF1KE2 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP ::::::::::::::::::::::::::: XP_016 RQDVQEALEGVSFIAQHMKNDDEDQSVSQKQTPRWGLGCRWFT 430 440 450 460 >>XP_016877378 (OMIM: 118509) PREDICTED: neuronal acetyl (449 aa) initn: 2988 init1: 2988 opt: 2988 Z-score: 3080.0 bits: 579.3 E(85289): 8.1e-165 Smith-Waterman score: 2988; 100.0% identity (100.0% similar) in 446 aa overlap (1-446:1-446) 10 20 30 40 50 60 pF1KE2 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP :::::::::::::::::::::::::: XP_016 RQDVQEALEGVSFIAQHMKNDDEDQSSLC 430 440 >>XP_011519493 (OMIM: 118509) PREDICTED: neuronal acetyl (424 aa) initn: 2888 init1: 2888 opt: 2888 Z-score: 2977.6 bits: 560.2 E(85289): 4.1e-159 Smith-Waterman score: 2888; 100.0% identity (100.0% similar) in 424 aa overlap (75-498:1-424) 50 60 70 80 90 100 pF1KE2 RPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILR :::::::::::::::::::::::::::::: XP_011 MTTNVWLKQEWTDYRLTWNSSRYEGVNILR 10 20 30 110 120 130 140 150 160 pF1KE2 IPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQ 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE2 QNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTY 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE2 DFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKI 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE2 VPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTF 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE2 LFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGST 280 290 300 310 320 330 410 420 430 440 450 460 pF1KE2 PVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLW 340 350 360 370 380 390 470 480 490 pF1KE2 VFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD :::::::::::::::::::::::::::::::::: XP_011 VFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD 400 410 420 >>XP_011519492 (OMIM: 118509) PREDICTED: neuronal acetyl (424 aa) initn: 2888 init1: 2888 opt: 2888 Z-score: 2977.6 bits: 560.2 E(85289): 4.1e-159 Smith-Waterman score: 2888; 100.0% identity (100.0% similar) in 424 aa overlap (75-498:1-424) 50 60 70 80 90 100 pF1KE2 RPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILR :::::::::::::::::::::::::::::: XP_011 MTTNVWLKQEWTDYRLTWNSSRYEGVNILR 10 20 30 110 120 130 140 150 160 pF1KE2 IPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQ 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE2 QNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTY 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE2 DFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKI 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE2 VPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTF 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE2 LFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGST 280 290 300 310 320 330 410 420 430 440 450 460 pF1KE2 PVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLW 340 350 360 370 380 390 470 480 490 pF1KE2 VFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD :::::::::::::::::::::::::::::::::: XP_011 VFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD 400 410 420 498 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 09:29:00 2016 done: Sun Nov 6 09:29:01 2016 Total Scan time: 9.710 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]