FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2439, 143 aa 1>>>pF1KE2439 143 - 143 aa - 143 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1216+/-0.000302; mu= 13.2397+/- 0.019 mean_var=82.0507+/-15.881, 0's: 0 Z-trim(119.6): 45 B-trim: 339 in 2/49 Lambda= 0.141590 statistics sampled from 33722 (33774) to 33722 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.767), E-opt: 0.2 (0.396), width: 16 Scan time: 4.260 The best scores are: opt bits E(85289) NP_001012333 (OMIM: 162096) midkine isoform a prec ( 143) 1019 216.7 9.9e-57 NP_002382 (OMIM: 162096) midkine isoform a precurs ( 143) 1019 216.7 9.9e-57 NP_001012334 (OMIM: 162096) midkine isoform a prec ( 143) 1019 216.7 9.9e-57 XP_011518418 (OMIM: 162096) PREDICTED: midkine iso ( 143) 1019 216.7 9.9e-57 NP_001257479 (OMIM: 162096) midkine isoform a prec ( 143) 1019 216.7 9.9e-57 NP_001257480 (OMIM: 162096) midkine isoform a prec ( 143) 1019 216.7 9.9e-57 XP_016873253 (OMIM: 162096) PREDICTED: midkine iso ( 143) 1019 216.7 9.9e-57 NP_001308315 (OMIM: 162095) pleiotrophin isoform 1 ( 168) 509 112.6 2.5e-25 NP_002816 (OMIM: 162095) pleiotrophin isoform 1 pr ( 168) 509 112.6 2.5e-25 XP_016867962 (OMIM: 162095) PREDICTED: pleiotrophi ( 167) 500 110.8 9.1e-25 NP_001308316 (OMIM: 162095) pleiotrophin isoform 2 ( 167) 500 110.8 9.1e-25 NP_001257481 (OMIM: 162096) midkine isoform b prec ( 87) 433 96.8 7.5e-21 >>NP_001012333 (OMIM: 162096) midkine isoform a precurso (143 aa) initn: 1019 init1: 1019 opt: 1019 Z-score: 1139.5 bits: 216.7 E(85289): 9.9e-57 Smith-Waterman score: 1019; 100.0% identity (100.0% similar) in 143 aa overlap (1-143:1-143) 10 20 30 40 50 60 pF1KE2 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI 70 80 90 100 110 120 130 140 pF1KE2 RVTKPCTPKTKAKAKAKKGKGKD ::::::::::::::::::::::: NP_001 RVTKPCTPKTKAKAKAKKGKGKD 130 140 >>NP_002382 (OMIM: 162096) midkine isoform a precursor [ (143 aa) initn: 1019 init1: 1019 opt: 1019 Z-score: 1139.5 bits: 216.7 E(85289): 9.9e-57 Smith-Waterman score: 1019; 100.0% identity (100.0% similar) in 143 aa overlap (1-143:1-143) 10 20 30 40 50 60 pF1KE2 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI 70 80 90 100 110 120 130 140 pF1KE2 RVTKPCTPKTKAKAKAKKGKGKD ::::::::::::::::::::::: NP_002 RVTKPCTPKTKAKAKAKKGKGKD 130 140 >>NP_001012334 (OMIM: 162096) midkine isoform a precurso (143 aa) initn: 1019 init1: 1019 opt: 1019 Z-score: 1139.5 bits: 216.7 E(85289): 9.9e-57 Smith-Waterman score: 1019; 100.0% identity (100.0% similar) in 143 aa overlap (1-143:1-143) 10 20 30 40 50 60 pF1KE2 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI 70 80 90 100 110 120 130 140 pF1KE2 RVTKPCTPKTKAKAKAKKGKGKD ::::::::::::::::::::::: NP_001 RVTKPCTPKTKAKAKAKKGKGKD 130 140 >>XP_011518418 (OMIM: 162096) PREDICTED: midkine isoform (143 aa) initn: 1019 init1: 1019 opt: 1019 Z-score: 1139.5 bits: 216.7 E(85289): 9.9e-57 Smith-Waterman score: 1019; 100.0% identity (100.0% similar) in 143 aa overlap (1-143:1-143) 10 20 30 40 50 60 pF1KE2 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI 70 80 90 100 110 120 130 140 pF1KE2 RVTKPCTPKTKAKAKAKKGKGKD ::::::::::::::::::::::: XP_011 RVTKPCTPKTKAKAKAKKGKGKD 130 140 >>NP_001257479 (OMIM: 162096) midkine isoform a precurso (143 aa) initn: 1019 init1: 1019 opt: 1019 Z-score: 1139.5 bits: 216.7 E(85289): 9.9e-57 Smith-Waterman score: 1019; 100.0% identity (100.0% similar) in 143 aa overlap (1-143:1-143) 10 20 30 40 50 60 pF1KE2 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI 70 80 90 100 110 120 130 140 pF1KE2 RVTKPCTPKTKAKAKAKKGKGKD ::::::::::::::::::::::: NP_001 RVTKPCTPKTKAKAKAKKGKGKD 130 140 >>NP_001257480 (OMIM: 162096) midkine isoform a precurso (143 aa) initn: 1019 init1: 1019 opt: 1019 Z-score: 1139.5 bits: 216.7 E(85289): 9.9e-57 Smith-Waterman score: 1019; 100.0% identity (100.0% similar) in 143 aa overlap (1-143:1-143) 10 20 30 40 50 60 pF1KE2 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI 70 80 90 100 110 120 130 140 pF1KE2 RVTKPCTPKTKAKAKAKKGKGKD ::::::::::::::::::::::: NP_001 RVTKPCTPKTKAKAKAKKGKGKD 130 140 >>XP_016873253 (OMIM: 162096) PREDICTED: midkine isoform (143 aa) initn: 1019 init1: 1019 opt: 1019 Z-score: 1139.5 bits: 216.7 E(85289): 9.9e-57 Smith-Waterman score: 1019; 100.0% identity (100.0% similar) in 143 aa overlap (1-143:1-143) 10 20 30 40 50 60 pF1KE2 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI 70 80 90 100 110 120 130 140 pF1KE2 RVTKPCTPKTKAKAKAKKGKGKD ::::::::::::::::::::::: XP_016 RVTKPCTPKTKAKAKAKKGKGKD 130 140 >>NP_001308315 (OMIM: 162095) pleiotrophin isoform 1 pre (168 aa) initn: 538 init1: 333 opt: 509 Z-score: 575.6 bits: 112.6 E(85289): 2.5e-25 Smith-Waterman score: 509; 48.4% identity (72.5% similar) in 153 aa overlap (2-142:9-161) 10 20 30 40 50 pF1KE2 MQHRGF---LLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSK :.: : .: .. : :. .: : ::.: .: :.:.:: :. :.:.: NP_001 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG 10 20 30 40 50 60 60 70 80 90 100 pF1KE2 DCGVGFREGT-CGA---QTQRI-RCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQG :::.: :::: :: ::.. ::..::::::.:::.:::.:. :: :: .:. :.: : NP_001 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG 70 80 90 100 110 120 110 120 130 140 pF1KE2 TLKKARYNAQCQETIRVTKPC----TPKTKAKAKAKKGKGKD .::.: .::.::.:. ..::: :: .:..: :: .:: NP_001 SLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD 130 140 150 160 >>NP_002816 (OMIM: 162095) pleiotrophin isoform 1 precur (168 aa) initn: 538 init1: 333 opt: 509 Z-score: 575.6 bits: 112.6 E(85289): 2.5e-25 Smith-Waterman score: 509; 48.4% identity (72.5% similar) in 153 aa overlap (2-142:9-161) 10 20 30 40 50 pF1KE2 MQHRGF---LLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSK :.: : .: .. : :. .: : ::.: .: :.:.:: :. :.:.: NP_002 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG 10 20 30 40 50 60 60 70 80 90 100 pF1KE2 DCGVGFREGT-CGA---QTQRI-RCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQG :::.: :::: :: ::.. ::..::::::.:::.:::.:. :: :: .:. :.: : NP_002 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG 70 80 90 100 110 120 110 120 130 140 pF1KE2 TLKKARYNAQCQETIRVTKPC----TPKTKAKAKAKKGKGKD .::.: .::.::.:. ..::: :: .:..: :: .:: NP_002 SLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD 130 140 150 160 >>XP_016867962 (OMIM: 162095) PREDICTED: pleiotrophin is (167 aa) initn: 539 init1: 334 opt: 500 Z-score: 565.7 bits: 110.8 E(85289): 9.1e-25 Smith-Waterman score: 500; 48.0% identity (72.0% similar) in 150 aa overlap (2-143:9-158) 10 20 30 40 50 pF1KE2 MQHRGF---LLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSK :.: : .: .. : :. .: : ::.: .: :.:.:: :. :.:.: XP_016 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG 10 20 30 40 50 60 60 70 80 90 100 pF1KE2 DCGVGFREGT-CGA---QTQRI-RCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQG :::.: :::: :: ::.. ::..::::::.:::.:::.:. :: :: .:. :.: : XP_016 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG 70 80 90 100 110 120 110 120 130 140 pF1KE2 TLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD .::.: .::.::.:. ..::: :: : . .: : :. XP_016 SLKRALHNAECQKTVTISKPCGKLTKPKPQESKKKKKEGKKQEKMLD 130 140 150 160 143 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 20:00:06 2016 done: Mon Nov 7 20:00:07 2016 Total Scan time: 4.260 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]