FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2445, 449 aa 1>>>pF1KE2445 449 - 449 aa - 449 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0057+/-0.000481; mu= 14.0395+/- 0.030 mean_var=75.6381+/-15.013, 0's: 0 Z-trim(109.2): 80 B-trim: 21 in 1/50 Lambda= 0.147470 statistics sampled from 17321 (17348) to 17321 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.569), E-opt: 0.2 (0.203), width: 16 Scan time: 8.740 The best scores are: opt bits E(85289) NP_060379 (OMIM: 614917,614922) required for meiot ( 449) 2953 638.2 1.3e-182 NP_001258866 (OMIM: 614917,614922) required for me ( 279) 1835 400.3 3.4e-111 XP_005267097 (OMIM: 614917,614922) PREDICTED: requ ( 238) 1566 343.0 5e-94 XP_016866477 (OMIM: 614917,614922) PREDICTED: requ ( 238) 1566 343.0 5e-94 >>NP_060379 (OMIM: 614917,614922) required for meiotic n (449 aa) initn: 2953 init1: 2953 opt: 2953 Z-score: 3399.5 bits: 638.2 E(85289): 1.3e-182 Smith-Waterman score: 2953; 100.0% identity (100.0% similar) in 449 aa overlap (1-449:1-449) 10 20 30 40 50 60 pF1KE2 MPATLLRAVARSHHILSKAHQCRRIGHLMLKPLKEFENTTCSTLTIRQSLDLFLPDKTAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MPATLLRAVARSHHILSKAHQCRRIGHLMLKPLKEFENTTCSTLTIRQSLDLFLPDKTAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GLNKSQILEMNQKKSDTSMLSPLNAARCQDEKAHLPTMKSFGTHRRVTHKPNLLGSKWFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 GLNKSQILEMNQKKSDTSMLSPLNAARCQDEKAHLPTMKSFGTHRRVTHKPNLLGSKWFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 KILKRHFSSVSTETFVPKQDFPQVKRPLKASRTRQPSRTNLPVLSVNEDLMHCTAFATAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 KILKRHFSSVSTETFVPKQDFPQVKRPLKASRTRQPSRTNLPVLSVNEDLMHCTAFATAD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 EYHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 EYHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 DKTMKHVMKVLEKHEIQPYEIALVHWENEELNYIKIEGQSKLHRGEIKLNSELDLDDAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DKTMKHVMKVLEKHEIQPYEIALVHWENEELNYIKIEGQSKLHRGEIKLNSELDLDDAIL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 EKFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKVKLSHEEVMQKIGELFALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 EKFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKVKLSHEEVMQKIGELFALR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 HRINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMELTDLMRNHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 HRINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMELTDLMRNHL 370 380 390 400 410 420 430 440 pF1KE2 NEKRALRLEWMIVILITIEVMFELGRVFF ::::::::::::::::::::::::::::: NP_060 NEKRALRLEWMIVILITIEVMFELGRVFF 430 440 >>NP_001258866 (OMIM: 614917,614922) required for meioti (279 aa) initn: 1835 init1: 1835 opt: 1835 Z-score: 2117.3 bits: 400.3 E(85289): 3.4e-111 Smith-Waterman score: 1835; 100.0% identity (100.0% similar) in 279 aa overlap (171-449:1-279) 150 160 170 180 190 200 pF1KE2 FPQVKRPLKASRTRQPSRTNLPVLSVNEDLMHCTAFATADEYHLGNLSQDLASHGYVEVT :::::::::::::::::::::::::::::: NP_001 MHCTAFATADEYHLGNLSQDLASHGYVEVT 10 20 30 210 220 230 240 250 260 pF1KE2 SLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVKDKTMKHVMKVLEKHEIQPYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVKDKTMKHVMKVLEKHEIQPYE 40 50 60 70 80 90 270 280 290 300 310 320 pF1KE2 IALVHWENEELNYIKIEGQSKLHRGEIKLNSELDLDDAILEKFAFSNALCLSVKLAIWEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IALVHWENEELNYIKIEGQSKLHRGEIKLNSELDLDDAILEKFAFSNALCLSVKLAIWEA 100 110 120 130 140 150 330 340 350 360 370 380 pF1KE2 SLDKFIESIQSIPEALKAGKKVKLSHEEVMQKIGELFALRHRINLSSDFLITPDFYWDRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLDKFIESIQSIPEALKAGKKVKLSHEEVMQKIGELFALRHRINLSSDFLITPDFYWDRE 160 170 180 190 200 210 390 400 410 420 430 440 pF1KE2 NLEGLYDKTCQFLSIGRRVKVMNEKLQHCMELTDLMRNHLNEKRALRLEWMIVILITIEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLEGLYDKTCQFLSIGRRVKVMNEKLQHCMELTDLMRNHLNEKRALRLEWMIVILITIEV 220 230 240 250 260 270 pF1KE2 MFELGRVFF ::::::::: NP_001 MFELGRVFF >>XP_005267097 (OMIM: 614917,614922) PREDICTED: required (238 aa) initn: 1566 init1: 1566 opt: 1566 Z-score: 1809.1 bits: 343.0 E(85289): 5e-94 Smith-Waterman score: 1566; 100.0% identity (100.0% similar) in 238 aa overlap (212-449:1-238) 190 200 210 220 230 240 pF1KE2 YHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVKD :::::::::::::::::::::::::::::: XP_005 MGVENSAKEGDPGTIFFFREGAAVFWNVKD 10 20 30 250 260 270 280 290 300 pF1KE2 KTMKHVMKVLEKHEIQPYEIALVHWENEELNYIKIEGQSKLHRGEIKLNSELDLDDAILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KTMKHVMKVLEKHEIQPYEIALVHWENEELNYIKIEGQSKLHRGEIKLNSELDLDDAILE 40 50 60 70 80 90 310 320 330 340 350 360 pF1KE2 KFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKVKLSHEEVMQKIGELFALRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKVKLSHEEVMQKIGELFALRH 100 110 120 130 140 150 370 380 390 400 410 420 pF1KE2 RINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMELTDLMRNHLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMELTDLMRNHLN 160 170 180 190 200 210 430 440 pF1KE2 EKRALRLEWMIVILITIEVMFELGRVFF :::::::::::::::::::::::::::: XP_005 EKRALRLEWMIVILITIEVMFELGRVFF 220 230 >>XP_016866477 (OMIM: 614917,614922) PREDICTED: required (238 aa) initn: 1566 init1: 1566 opt: 1566 Z-score: 1809.1 bits: 343.0 E(85289): 5e-94 Smith-Waterman score: 1566; 100.0% identity (100.0% similar) in 238 aa overlap (212-449:1-238) 190 200 210 220 230 240 pF1KE2 YHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVKD :::::::::::::::::::::::::::::: XP_016 MGVENSAKEGDPGTIFFFREGAAVFWNVKD 10 20 30 250 260 270 280 290 300 pF1KE2 KTMKHVMKVLEKHEIQPYEIALVHWENEELNYIKIEGQSKLHRGEIKLNSELDLDDAILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KTMKHVMKVLEKHEIQPYEIALVHWENEELNYIKIEGQSKLHRGEIKLNSELDLDDAILE 40 50 60 70 80 90 310 320 330 340 350 360 pF1KE2 KFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKVKLSHEEVMQKIGELFALRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKVKLSHEEVMQKIGELFALRH 100 110 120 130 140 150 370 380 390 400 410 420 pF1KE2 RINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMELTDLMRNHLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMELTDLMRNHLN 160 170 180 190 200 210 430 440 pF1KE2 EKRALRLEWMIVILITIEVMFELGRVFF :::::::::::::::::::::::::::: XP_016 EKRALRLEWMIVILITIEVMFELGRVFF 220 230 449 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 20:00:45 2016 done: Mon Nov 7 20:00:47 2016 Total Scan time: 8.740 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]