Result of FASTA (omim) for
pF1KE2457
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2457, 1176 aa
1>>>pF1KE2457 1176 - 1176 aa - 1176 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.6308+/-0.000444; mu= 16.5921+/- 0.028
mean_var=136.4393+/-26.456, 0's: 0 Z-trim(114.8): 93 B-trim: 49 in 1/52
Lambda= 0.109801
statistics sampled from 24756 (24851) to 24756 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.645), E-opt: 0.2 (0.291), width: 16
Scan time: 11.920
The best scores are: opt bits E(85289)
NP_004523 (OMIM: 158372) mucin-4 isoform d precurs (1176) 8301 1327.9 0
NP_060876 (OMIM: 158372) mucin-4 isoform a precurs (5412) 8100 1296.7 0
NP_001309397 (OMIM: 158372) mucin-4 isoform f prec (7418) 8081 1293.8 0
NP_612154 (OMIM: 158372) mucin-4 isoform e precurs (1125) 7763 1242.7 0
NP_062547 (OMIM: 615825) sushi domain-containing p ( 822) 498 91.7 2e-17
XP_011542497 (OMIM: 131390) PREDICTED: nidogen-1 i (1205) 257 53.7 8.4e-06
NP_002499 (OMIM: 131390) nidogen-1 precursor [Homo (1247) 257 53.7 8.6e-06
XP_005267464 (OMIM: 605399) PREDICTED: nidogen-2 i (1327) 227 49.0 0.00024
XP_005267463 (OMIM: 605399) PREDICTED: nidogen-2 i (1354) 227 49.0 0.00025
NP_031387 (OMIM: 605399) nidogen-2 precursor [Homo (1375) 227 49.0 0.00025
XP_005267462 (OMIM: 605399) PREDICTED: nidogen-2 i (1402) 227 49.0 0.00025
XP_016865268 (OMIM: 603745) PREDICTED: slit homolo (1460) 209 46.1 0.0019
NP_003053 (OMIM: 603745) slit homolog 3 protein is (1523) 209 46.2 0.0019
NP_001258875 (OMIM: 603745) slit homolog 3 protein (1530) 209 46.2 0.0019
XP_011518010 (OMIM: 261100,602997) PREDICTED: cubi (2867) 201 45.1 0.0074
XP_011514552 (OMIM: 158371) PREDICTED: mucin-3A is (3076) 201 45.2 0.0078
XP_016867720 (OMIM: 158371) PREDICTED: mucin-3A is (3143) 201 45.2 0.0079
XP_011514551 (OMIM: 158371) PREDICTED: mucin-3A is (3245) 201 45.2 0.0081
XP_011514549 (OMIM: 158371) PREDICTED: mucin-3A is (3296) 201 45.2 0.0082
XP_011514548 (OMIM: 158371) PREDICTED: mucin-3A is (3313) 201 45.2 0.0082
NP_005951 (OMIM: 158371) mucin-3A precursor [Homo (3323) 201 45.2 0.0082
NP_001072 (OMIM: 261100,602997) cubilin precursor (3623) 201 45.2 0.0088
>>NP_004523 (OMIM: 158372) mucin-4 isoform d precursor [ (1176 aa)
initn: 8301 init1: 8301 opt: 8301 Z-score: 7111.9 bits: 1327.9 E(85289): 0
Smith-Waterman score: 8301; 99.7% identity (100.0% similar) in 1176 aa overlap (1-1176:1-1176)
10 20 30 40 50 60
pF1KE2 MKGARWRRVPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MKGARWRRVPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ETFYGEHSLLVQQAESWIRKITNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAILST
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
NP_004 ETFYGEHSLLVQQAESWIRKMTNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAILST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 DGSRSYALFLYQSGGMQWDVAQRSGKPVLMGFSSGDGYFENSPLMSQPVWERYRPDRFLN
:::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::
NP_004 DGSRSYALFLYQSGGMQWDVAQRSGNPVLMGFSSGDGYFENSPLMSQPVWERYRPDRFLN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 VSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWCCRWND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWCCRWND
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 KPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 SFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 HEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHSSASLPPEYQNRTEGL
::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::
NP_004 HEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYPPSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYPPSI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 NGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 RSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSED
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 ACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYIS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 QTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNASVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNASVA
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 YRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 VEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 GFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGA
1090 1100 1110 1120 1130 1140
1150 1160 1170
pF1KE2 LGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP
::::::::::::::::::::::::::::::::::::
NP_004 LGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP
1150 1160 1170
>>NP_060876 (OMIM: 158372) mucin-4 isoform a precursor [ (5412 aa)
initn: 8100 init1: 8100 opt: 8100 Z-score: 6931.1 bits: 1296.7 E(85289): 0
Smith-Waterman score: 8100; 99.7% identity (100.0% similar) in 1150 aa overlap (27-1176:4263-5412)
10 20 30 40 50
pF1KE2 MKGARWRRVPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIIS
::::::::::::::::::::::::::::::
NP_060 VSTGHATPLAVSSATSASTVSSDSPLKMETPGMTTPSLKTDGGRRTATSPPPTTSQTIIS
4240 4250 4260 4270 4280 4290
60 70 80 90 100 110
pF1KE2 TIPSTAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 TIPSTAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGS
4300 4310 4320 4330 4340 4350
120 130 140 150 160 170
pF1KE2 SLRDSLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SLRDSLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTF
4360 4370 4380 4390 4400 4410
180 190 200 210 220 230
pF1KE2 YQEYETFYGEHSLLVQQAESWIRKITNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQA
::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
NP_060 YQEYETFYGEHSLLVQQAESWIRKMTNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQA
4420 4430 4440 4450 4460 4470
240 250 260 270 280 290
pF1KE2 ILSTDGSRSYALFLYQSGGMQWDVAQRSGKPVLMGFSSGDGYFENSPLMSQPVWERYRPD
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
NP_060 ILSTDGSRSYALFLYQSGGMQWDVAQRSGNPVLMGFSSGDGYFENSPLMSQPVWERYRPD
4480 4490 4500 4510 4520 4530
300 310 320 330 340 350
pF1KE2 RFLNSNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RFLNSNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDL
4540 4550 4560 4570 4580 4590
360 370 380 390 400 410
pF1KE2 RFQPVSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RFQPVSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWCC
4600 4610 4620 4630 4640 4650
420 430 440 450 460 470
pF1KE2 RWNDKPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RWNDKPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQ
4660 4670 4680 4690 4700 4710
480 490 500 510 520 530
pF1KE2 DGNSSFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DGNSSFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVT
4720 4730 4740 4750 4760 4770
540 550 560 570 580 590
pF1KE2 FQPDHEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHSSASLPPEYQNR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_060 FQPDHEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNR
4780 4790 4800 4810 4820 4830
600 610 620 630 640 650
pF1KE2 TEGLLGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 TEGLLGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFT
4840 4850 4860 4870 4880 4890
660 670 680 690 700 710
pF1KE2 PVFYSQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PVFYSQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQY
4900 4910 4920 4930 4940 4950
720 730 740 750 760 770
pF1KE2 PPSINGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PPSINGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTL
4960 4970 4980 4990 5000 5010
780 790 800 810 820 830
pF1KE2 EILARSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EILARSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCE
5020 5030 5040 5050 5060 5070
840 850 860 870 880 890
pF1KE2 GSEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GSEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGH
5080 5090 5100 5110 5120 5130
900 910 920 930 940 950
pF1KE2 CYISQTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 CYISQTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVN
5140 5150 5160 5170 5180 5190
960 970 980 990 1000 1010
pF1KE2 ASVAYRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ASVAYRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQL
5200 5210 5220 5230 5240 5250
1020 1030 1040 1050 1060 1070
pF1KE2 LAAVVEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LAAVVEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVY
5260 5270 5280 5290 5300 5310
1080 1090 1100 1110 1120 1130
pF1KE2 SPQSGFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SPQSGFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGI
5320 5330 5340 5350 5360 5370
1140 1150 1160 1170
pF1KE2 FFGALGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP
::::::::::::::::::::::::::::::::::::::::
NP_060 FFGALGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP
5380 5390 5400 5410
>--
initn: 287 init1: 236 opt: 259 Z-score: 218.3 bits: 54.6 E(85289): 2e-05
Smith-Waterman score: 259; 58.3% identity (66.7% similar) in 72 aa overlap (1-72:1-70)
10 20 30 40 50 60
pF1KE2 MKGARWRRVPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPS
:::::::::::::::::::::::::::: : .: : : .::. : : : :
NP_060 MKGARWRRVPWVSLSCLCLCLLPHVVPGTTEDTLIT--GSKTAAPVTSTGSTTATLEGQS
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 TAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRD
:: .:.. :
NP_060 TAASSRTSNQDISASSQNHQTKSTETTSKAQTDTLTQMMTSTLFSSPSVHNVMETAPPDE
60 70 80 90 100 110
>>NP_001309397 (OMIM: 158372) mucin-4 isoform f precurso (7418 aa)
initn: 8081 init1: 8081 opt: 8081 Z-score: 6913.1 bits: 1293.8 E(85289): 0
Smith-Waterman score: 8081; 99.7% identity (99.9% similar) in 1149 aa overlap (28-1176:6270-7418)
10 20 30 40 50
pF1KE2 MKGARWRRVPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIIST
::::::::::::::::::::::::::::::
NP_001 STGHATPLAVSSATSASTVSSDSPLKMETSGMTTPSLKTDGGRRTATSPPPTTSQTIIST
6240 6250 6260 6270 6280 6290
60 70 80 90 100 110
pF1KE2 IPSTAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSS
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_001 IPSTAMHTRSTAAPIPILPERGVSLFPYGADAGDLEFVRRTVDFTSPLFKPATGFPLGSS
6300 6310 6320 6330 6340 6350
120 130 140 150 160 170
pF1KE2 LRDSLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRDSLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFY
6360 6370 6380 6390 6400 6410
180 190 200 210 220 230
pF1KE2 QEYETFYGEHSLLVQQAESWIRKITNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAI
:::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::
NP_001 QEYETFYGEHSLLVQQAESWIRKMTNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAI
6420 6430 6440 6450 6460 6470
240 250 260 270 280 290
pF1KE2 LSTDGSRSYALFLYQSGGMQWDVAQRSGKPVLMGFSSGDGYFENSPLMSQPVWERYRPDR
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_001 LSTDGSRSYALFLYQSGGMQWDVAQRSGNPVLMGFSSGDGYFENSPLMSQPVWERYRPDR
6480 6490 6500 6510 6520 6530
300 310 320 330 340 350
pF1KE2 FLNSNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLNSNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLR
6540 6550 6560 6570 6580 6590
360 370 380 390 400 410
pF1KE2 FQPVSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWCCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQPVSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWCCR
6600 6610 6620 6630 6640 6650
420 430 440 450 460 470
pF1KE2 WNDKPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WNDKPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQD
6660 6670 6680 6690 6700 6710
480 490 500 510 520 530
pF1KE2 GNSSFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNSSFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTF
6720 6730 6740 6750 6760 6770
540 550 560 570 580 590
pF1KE2 QPDHEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHSSASLPPEYQNRT
:::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::
NP_001 QPDHEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRT
6780 6790 6800 6810 6820 6830
600 610 620 630 640 650
pF1KE2 EGLLGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGLLGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTP
6840 6850 6860 6870 6880 6890
660 670 680 690 700 710
pF1KE2 VFYSQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFYSQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYP
6900 6910 6920 6930 6940 6950
720 730 740 750 760 770
pF1KE2 PSINGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSINGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLE
6960 6970 6980 6990 7000 7010
780 790 800 810 820 830
pF1KE2 ILARSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILARSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEG
7020 7030 7040 7050 7060 7070
840 850 860 870 880 890
pF1KE2 SEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHC
7080 7090 7100 7110 7120 7130
900 910 920 930 940 950
pF1KE2 YISQTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YISQTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNA
7140 7150 7160 7170 7180 7190
960 970 980 990 1000 1010
pF1KE2 SVAYRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVAYRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQLL
7200 7210 7220 7230 7240 7250
1020 1030 1040 1050 1060 1070
pF1KE2 AAVVEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAVVEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYS
7260 7270 7280 7290 7300 7310
1080 1090 1100 1110 1120 1130
pF1KE2 PQSGFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQSGFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGIF
7320 7330 7340 7350 7360 7370
1140 1150 1160 1170
pF1KE2 FGALGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP
:::::::::::::::::::::::::::::::::::::::
NP_001 FGALGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP
7380 7390 7400 7410
>--
initn: 298 init1: 230 opt: 253 Z-score: 211.4 bits: 53.8 E(85289): 4.9e-05
Smith-Waterman score: 253; 56.9% identity (65.3% similar) in 72 aa overlap (1-72:1-70)
10 20 30 40 50 60
pF1KE2 MKGARWRRVPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPS
:::::::::::::::::::::::::::: : .: : : .: . : : : :
NP_001 MKGARWRRVPWVSLSCLCLCLLPHVVPGTTEDTLIT--GSKTPAPVTSTGSTTATLEGQS
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 TAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRD
:: .:.. :
NP_001 TAASSRTSNQDISASSQNHQTKSTETTSKAQTDTLTQMMTSTLFSSPSVHNVMETVTQET
60 70 80 90 100 110
>>NP_612154 (OMIM: 158372) mucin-4 isoform e precursor [ (1125 aa)
initn: 7762 init1: 7762 opt: 7763 Z-score: 6651.5 bits: 1242.7 E(85289): 0
Smith-Waterman score: 7861; 95.4% identity (95.7% similar) in 1176 aa overlap (1-1176:1-1125)
10 20 30 40 50 60
pF1KE2 MKGARWRRVPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPS
::::::::::::::::::::::::::::
NP_612 MKGARWRRVPWVSLSCLCLCLLPHVVPG--------------------------------
10 20
70 80 90 100 110 120
pF1KE2 TAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRD
:::::::::::::::::::::::::::::::::::::::::
NP_612 -------------------VSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRD
30 40 50 60
130 140 150 160 170 180
pF1KE2 SLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 SLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEY
70 80 90 100 110 120
190 200 210 220 230 240
pF1KE2 ETFYGEHSLLVQQAESWIRKITNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAILST
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
NP_612 ETFYGEHSLLVQQAESWIRKMTNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAILST
130 140 150 160 170 180
250 260 270 280 290 300
pF1KE2 DGSRSYALFLYQSGGMQWDVAQRSGKPVLMGFSSGDGYFENSPLMSQPVWERYRPDRFLN
:::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::
NP_612 DGSRSYALFLYQSGGMQWDVAQRSGNPVLMGFSSGDGYFENSPLMSQPVWERYRPDRFLN
190 200 210 220 230 240
310 320 330 340 350 360
pF1KE2 SNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 SNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQP
250 260 270 280 290 300
370 380 390 400 410 420
pF1KE2 VSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWCCRWND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 VSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWCCRWND
310 320 330 340 350 360
430 440 450 460 470 480
pF1KE2 KPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 KPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNS
370 380 390 400 410 420
490 500 510 520 530 540
pF1KE2 SFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 SFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPD
430 440 450 460 470 480
550 560 570 580 590 600
pF1KE2 HEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHSSASLPPEYQNRTEGL
::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::
NP_612 HEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGL
490 500 510 520 530 540
610 620 630 640 650 660
pF1KE2 LGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 LGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFY
550 560 570 580 590 600
670 680 690 700 710 720
pF1KE2 SQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYPPSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 SQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYPPSI
610 620 630 640 650 660
730 740 750 760 770 780
pF1KE2 NGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 NGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILA
670 680 690 700 710 720
790 800 810 820 830 840
pF1KE2 RSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 RSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSED
730 740 750 760 770 780
850 860 870 880 890 900
pF1KE2 ACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 ACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYIS
790 800 810 820 830 840
910 920 930 940 950 960
pF1KE2 QTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNASVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 QTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNASVA
850 860 870 880 890 900
970 980 990 1000 1010 1020
pF1KE2 YRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 YRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAV
910 920 930 940 950 960
1030 1040 1050 1060 1070 1080
pF1KE2 VEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 VEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQS
970 980 990 1000 1010 1020
1090 1100 1110 1120 1130 1140
pF1KE2 GFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 GFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGA
1030 1040 1050 1060 1070 1080
1150 1160 1170
pF1KE2 LGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP
::::::::::::::::::::::::::::::::::::
NP_612 LGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP
1090 1100 1110 1120
>>NP_062547 (OMIM: 615825) sushi domain-containing prote (822 aa)
initn: 411 init1: 205 opt: 498 Z-score: 433.7 bits: 91.7 E(85289): 2e-17
Smith-Waterman score: 545; 25.1% identity (48.2% similar) in 809 aa overlap (9-742:6-745)
10 20 30 40 50 60
pF1KE2 MKGARWRRVPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPS
.:: .: : : : :: :. . .. . : : . : . : : . .
NP_062 MKPALLPW-ALLLLATALGPG--PGPTADAQESCSMRCGALDGPCSCHPTC-SGLGT
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 TAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRD
. :. . ::: : . : .:: : ..:: : . ..:
NP_062 CCLDFRDFC--LEILPYSGSMM-------GGKDFVVRHFKMSSP-----TDASVICRFKD
60 70 80 90
130 140 150 160 170 180
pF1KE2 SLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEY
:. :.. .:. :. .:: .:: : .. : : .: .
NP_062 SIQTL--GHV---DSSGQVHCV-SPL-LYESGRIPFTV----------SLDNGHSFPRAG
100 110 120 130 140
190 200 210 220 230 240
pF1KE2 ETFYGEHSLLVQQAESWIRKITNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAILST
:. . : :.. :. ...: ..:: : .. : . : :.:
NP_062 -TWLAVHPNKVSMMEK--SELVN----ETRWQYYGTANTSGNLSLTWHVKSLPTQTI---
150 160 170 180 190
250 260 270 280 290
pF1KE2 DGSRSYALFLYQSGGM----QWDVAQRSGKPVLMGFSSGDGYFENSPLMSQPVWERYRPD
. :. :. :: .: . : : ..: : .: . : ..:.:
NP_062 ----TIELWGYEETGMPYSQEWTAKWSYLYP-LATHIPNSGSFTFTPKPAPPSYQRWRVG
200 210 220 230 240
300 310 320 330
pF1KE2 --RFLNSNS--GLQGLQF---------YRLHREERPN----YRLECLQWLKSQPRWPSWG
:...:.. : . .: ..: . : . : .: : . . . :..
NP_062 ALRIIDSKNYAGQKDVQALWTNDHALAWHLSDDFREDPVAWARTQCQAWEELEDQLPNFL
250 260 270 280 290 300
340 350 360 370
pF1KE2 WNQVSCPCSWQQGRRDL-RF----------------QPVSI-------GRWGLGSRQLCS
. .:::. :.: : :: .: .. . :: : :
NP_062 EELPDCPCTLTQARADSGRFFTDYGCDMEQGSVCTYHPGAVHCVRSVQASLRYGSGQQCC
310 320 330 340 350 360
380 390 400 410 420
pF1KE2 FTS---------WRGGVCCSYG-PWGE--FREGWHVQRPWQLAQELEPQSWCCRWNDKPY
.:. :: . : :: :: .: . .. .:: :
NP_062 YTADGTQLLTADSSGGSTPDRGHDWGAPPFRTPPRVPSMSHWLYDVLSFYYCCLWAPD--
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 LCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFL
: :.:::: : .::::. : :::::..:.::...:::: :...:. : . ...
NP_062 -CPRYMQRRPSNDCRNYRPPRLASAFGDPHFVTFDGTNFTFNGRGEYVLLEA--ALTDLR
430 440 450 460 470 480
490 500 510 520 530
pF1KE2 LQGRTAQTGS------AQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTF
.:.: :: :. ...:.. : :.: .:.. : :. : . ...:::......:
NP_062 VQAR-AQPGTMSNGTETRGTGLTAVAVQEGNSDV--VEVR-LANRTGGLEVLLNQEVLSF
490 500 510 520 530
540 550 560 570 580 590
pF1KE2 QPDHEDGGGQETFNATGVLLS-RNGSEVSASFDGWATVSVIALSNILHSSASLPPEYQNR
: .. :..:: :..:: . . : . : . . .: :. :: .. ..
NP_062 TE-------QSWMDLKGMFLSVAAGDRVSIMLASGAGLEVSVQGPFLSVSVLLPEKFLTH
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE2 TEGLLGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQI-NGTGLLGKRNDQLPSNF
:.::::. ::.: ::: . .: ..:::. . :: :: .: . :...:: . : ::
NP_062 THGLLGTLNNDPTDDFTLHSGRVLPPGTSPQELFLFGANWTVHNASSLLTYDSWFLVHNF
600 610 620 630 640 650
660 670 680 690 700
pF1KE2 T----------PVFYSQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKN
:.: :. : : :.. . : : : .:. : . : : :: . .
NP_062 LYQPKHDPTFEPLFPSETTLNPSLAQEAAKLCGDDHFCNFDVAATGSLSTGTATRVAHQL
660 670 680 690 700 710
710 720 730 740 750 760
pF1KE2 YEQANATLNQYPPSINGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLL
... .:. : .. : . .:: .: ...
NP_062 HQRRMQSLQ---PVVSCGWLAPPPNGQKEGNRYLAGSTIYFHCDNGYSLAGAETSTCQAD
720 730 740 750 760
770 780 790 800 810 820
pF1KE2 WTPKSLEPFTLEILARSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCK
NP_062 GTWSSPTPKCQPGRSYAVLLGIIFGGLAVVAAVALVYVLLRRRKGNTHVWGAQP
770 780 790 800 810 820
>>XP_011542497 (OMIM: 131390) PREDICTED: nidogen-1 isofo (1205 aa)
initn: 240 init1: 100 opt: 257 Z-score: 225.2 bits: 53.7 E(85289): 8.4e-06
Smith-Waterman score: 308; 22.3% identity (46.5% similar) in 916 aa overlap (69-930:23-845)
40 50 60 70 80 90
pF1KE2 GRRTATSPPPTTSQTIISTIPSTAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRT
:.:. : .. :::.: : ::::. .
XP_011 MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQ--ELFPFGPGQGDLEL-EDG
10 20 30 40
100 110 120 130 140 150
pF1KE2 VDFTSPLFK--PATGFPLGSSLRDSLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPV
::.:: .. : : :.. :..: : :: : : . :.:. .: : .
XP_011 DDFVSPALELSGALRFYDRSDI-DAVYVTTNGIIATSEPPAK-ESHPGLFPPTFGA----
50 60 70 80 90 100
160 170 180 190 200 210
pF1KE2 ALVAPFWDDADFSTGRGTTFYQEYETFYGEHSLLVQQAESWIRKITNNGGYKARWALKVT
:::: : : . : : ..:.: . ..:.: ... . ... :. ::
XP_011 --VAPFLADLDTTDGLGKVYYREDLS-----PSITQRAAECVHRGFPEISFQPSSAVVVT
110 120 130 140 150
220 230 240 250 260
pF1KE2 WVNAHAY--PAQ---WTLGSNTYQAILSTDGSRSYALFLYQSGGMQWDVA----QRSGKP
: .. : :.. ::.::.:... : :::.::: :.:. .. . . :
XP_011 WESVAPYQGPSRDPDQKGKRNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVP
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE2 VLMGFSSGD-GYF-ENSPLMSQPVWERYRPDRFL-NSNSGLQGLQFYRLHREERPNYRLE
....::.:. :.. ... .. . .: . . .:::: ::. ... : .
XP_011 AVVAFSQGSVGFLWKSNGAYNIFANDRESVENLAKSSNSGQQGVWVFEIGSPATTNGVVP
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE2 CLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQPVS---IGRWGLGSRQLCSFTS-WR
: .. .. . . : .:. : : . : : . .. : : :
XP_011 ADVILGTEDGAEYDDEDEDYDLATTRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRR
280 290 300 310 320 330
390 400 410 420 430
pF1KE2 GGVCCSYGPWGE----FR---EGWHVQRPWQL-AQELEPQSWCCRWN-DKPYLCAL-YQQ
... :: : :. : .: :.: . ..:.: . .: :. :: .:
XP_011 AATERPLGPPTERTRSFQLAVETFHQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQ
340 350 360 370 380 390
440 450 460 470 480
pF1KE2 RRPHVGCATYRP----PQPAWMFGDPHITTLDGVSYTFNG-LGDFLLVGAQDGNSSFLLQ
:. : : : . :. . . .: :: . ..::... :
XP_011 CSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVF---
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 GRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGG
.. . .. . . .: . : : :: . : : . .. . .. : ..:
XP_011 ----ENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNG-
460 470 480 490 500
550 560 570 580 590 600
pF1KE2 GQETFNATGVLLSRNGSEVSASFDGWATVSVIA--LSNI-LHSSASLPPEYQNRTEGLLG
:. :: ..:. .::. : : :: .:.: :. .. : ..:.
XP_011 ----FSITGGEFTRQ-AEVT--FVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRV-----
510 520 530 540 550
610 620 630 640 650
pF1KE2 VWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQING-----TGLLGKRNDQLPSNFTP
:. .: ::.. : :.:.. . .. : .:. ::
XP_011 -----PQ----IPFGSSVHI-EPYTELYHYSTSVITSSSTREYTVTEPERDGASPSR---
560 570 580 590 600
660 670 680 690 700 710
pF1KE2 VFYSQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYP
.. : ... .. : : : :. .. : . : :.: . : .:
XP_011 IYTYQWRQTITFQE-----CVHD-----DSRPALPSTQQLSVDSVFVLYNQEEKIL-RYA
610 620 630 640 650
720 730 740 750 760
pF1KE2 PSINGGRVIEAYKGQTTLIQYT-SNAEDANFTLRD------SCT-DLELFENGTLLWTPK
: . : : :. : ... :.: . : .: .. . .: ..
XP_011 LSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYAVV
660 670 680 690 700 710
770 780 790 800 810 820
pF1KE2 SLEPFTLEILARSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGG
. .:.. . :: . : ..::.:. :.:: :.: :
XP_011 DQRPINY------CETGLHN--------CDIPQRAQCIYT-----GGSSYT---CSCLPG
720 730 740 750
830 840 850 860 870 880
pF1KE2 TFG--RYCEGSEDACEEP-CFPSVHC--VPGKGCEACPPNLTGDGRHCAALGSSFLCQNQ
: . :. . : :. : :.. : .::. : :. ::: : :
XP_011 FSGDGQACQ-DVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDG---------FRCVPG
760 770 780 790 800
890 900 910 920 930 940
pF1KE2 SCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLL
. : .. . .. . . .:. ::.. .: : ....::
XP_011 EVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPEC-DAHGHYAPTQCHGSTGYCWCVDR
810 820 830 840 850
950 960 970 980 990 1000
pF1KE2 SEEENASMAEVNASVAYRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRP
XP_011 DGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEG
860 870 880 890 900 910
>>NP_002499 (OMIM: 131390) nidogen-1 precursor [Homo sap (1247 aa)
initn: 240 init1: 100 opt: 257 Z-score: 225.0 bits: 53.7 E(85289): 8.6e-06
Smith-Waterman score: 308; 22.4% identity (45.8% similar) in 919 aa overlap (69-920:23-849)
40 50 60 70 80 90
pF1KE2 GRRTATSPPPTTSQTIISTIPSTAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRT
:.:. : .. :::.: : ::::. .
NP_002 MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQ--ELFPFGPGQGDLEL-EDG
10 20 30 40
100 110 120 130 140 150
pF1KE2 VDFTSPLFK--PATGFPLGSSLRDSLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPV
::.:: .. : : :.. :..: : :: : : . :.:. .: : .
NP_002 DDFVSPALELSGALRFYDRSDI-DAVYVTTNGIIATSEPPAK-ESHPGLFPPTFGA----
50 60 70 80 90 100
160 170 180 190 200 210
pF1KE2 ALVAPFWDDADFSTGRGTTFYQEYETFYGEHSLLVQQAESWIRKITNNGGYKARWALKVT
:::: : : . : : ..:.: . ..:.: ... . ... :. ::
NP_002 --VAPFLADLDTTDGLGKVYYREDLS-----PSITQRAAECVHRGFPEISFQPSSAVVVT
110 120 130 140 150
220 230 240 250 260
pF1KE2 WVNAHAY--PAQ---WTLGSNTYQAILSTDGSRSYALFLYQSGGMQWDVA----QRSGKP
: .. : :.. ::.::.:... : :::.::: :.:. .. . . :
NP_002 WESVAPYQGPSRDPDQKGKRNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVP
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE2 VLMGFSSGD-GYF-ENSPLMSQPVWERYRPDRFL-NSNSGLQGLQFYRLHREERPNYRLE
....::.:. :.. ... .. . .: . . .:::: ::. ... : .
NP_002 AVVAFSQGSVGFLWKSNGAYNIFANDRESVENLAKSSNSGQQGVWVFEIGSPATTNGVVP
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE2 CLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQPVS---IGRWGLGSRQLCSFTS-WR
: .. .. . . : .:. : : . : : . .. : : :
NP_002 ADVILGTEDGAEYDDEDEDYDLATTRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRR
280 290 300 310 320 330
390 400 410 420 430
pF1KE2 GGVCCSYGPWGE----FR---EGWHVQRPWQL-AQELEPQSWCCRWN-DKPYLCAL-YQQ
... :: : :. : .: :.: . ..:.: . .: :. :: .:
NP_002 AATERPLGPPTERTRSFQLAVETFHQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQ
340 350 360 370 380 390
440 450 460 470 480
pF1KE2 RRPHVGCATYRP----PQPAWMFGDPHITTLDGVSYTFNG-LGDFLLVGAQDGNSSFLLQ
:. : : : . :. . . .: :: . ..::... :
NP_002 CSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVF---
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 GRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGG
.. . .. . . .: . : : :: . : : . .. . .. : ..:
NP_002 ----ENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNG-
460 470 480 490 500
550 560 570 580 590 600
pF1KE2 GQETFNATGVLLSRNGSEVSASFDGWATVSVIA--LSNI-LHSSASLPPEYQNRTEGLLG
:. :: ..:. .:: .: : :: .:.: :. .. : ..:.
NP_002 ----FSITGGEFTRQ-AEV--TFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRV-----
510 520 530 540 550
610 620 630 640 650
pF1KE2 VWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQING-----TGLLGKRNDQLPSNFTP
:. .: ::.. : :.:.. . .. : .:. ::
NP_002 -----PQ----IPFGSSVHI-EPYTELYHYSTSVITSSSTREYTVTEPERDGASPSR---
560 570 580 590 600
660 670 680 690 700 710
pF1KE2 VFYSQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYP
.. : ... .. : : : :. .. : . : :.: . : .:
NP_002 IYTYQWRQTITFQE-----CVHD-----DSRPALPSTQQLSVDSVFVLYNQEEKIL-RYA
610 620 630 640 650
720 730 740 750 760 770
pF1KE2 PSINGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLE
: . : : : :. .: . . .: . : :.. :: :
NP_002 LSNSIGPVRE---GSPDALQ------NPCYIGTHGCDTNAACRPG-----PRT--QFTCE
660 670 680 690
780 790 800 810 820 830
pF1KE2 ILARSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKC-DGGTFG----
.::. . . . .:. . . ..: . :. . :.: .: :.
NP_002 -----CSIGFRGDGRTCYDIDECSEQPSVCGSHT--ICNNHPGTFRCECVEGYQFSDEGT
700 710 720 730 740
840 850 860 870
pF1KE2 ----------RYCEGSEDACEEPCFPSVHCVPGKG----CEACPPNLTGDGRHCAALGSS
::: . :. : ..:. : : .: :...:::. : .
NP_002 CVAVVDQRPINYCETGLHNCDIP--QRAQCIYTGGSSYTC-SCLPGFSGDGQACQDVDE-
750 760 770 780 790 800
880 890 900 910 920 930
pF1KE2 FLCQNQSC-PVNYCYNQGHCYISQTLGCQPM-----CTCPPAFTD-SRCFLAGNNFSPTV
:: . : : .::: . : :.: : :. .. .::
NP_002 --CQPSRCHPDAFCYNTPGSFTCQ---CKPGYQGDGFRCVPGEVEKTRCQHEREHILGAA
810 820 830 840 850 860
940 950 960 970 980 990
pF1KE2 NLELPLRVIQLLLSEEENASMAEVNASVAYRLGTLDMRAFLRNSQVERIDSAAPASGSPI
NP_002 GATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCL
870 880 890 900 910 920
>>XP_005267464 (OMIM: 605399) PREDICTED: nidogen-2 isofo (1327 aa)
initn: 181 init1: 122 opt: 227 Z-score: 198.9 bits: 49.0 E(85289): 0.00024
Smith-Waterman score: 253; 27.1% identity (53.2% similar) in 295 aa overlap (39-313:3-270)
10 20 30 40 50 60
pF1KE2 VPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPSTAMHTRST
: :.: : .: .. .: . :..
XP_005 MEGDRVAGRPV-LSSLPVLLLLP--LLMLRAA
10 20
70 80 90 100 110 120
pF1KE2 AAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRDSLYFTDNG
: . :.. :::.: . :: ..... : .: . : :. . . . ..:: ::
XP_005 A----LHPDE---LFPHGESWGD-QLLQEGDDESSAVVKLANPLHFYEARFSNLYVGTNG
30 40 50 60 70 80
130 140 150 160 170 180
pF1KE2 QII---FP-ESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEYETFY
: :: :..: ...:. .:. .::: : : : ::: ..:.: .
XP_005 IISTQDFPRETQYVDYDFPTDFPA----------IAPFLADIDTSHGRGRVLYREDTS--
90 100 110 120
190 200 210 220 230
pF1KE2 GEHSLLVQQAESWIRK-ITNNGGYKARWALKVTWVNAHAYPA--QWTLGS---NTYQAIL
.. : ..: . .. . :. .:: .. :: . .: : ::.::.:
XP_005 ---PAVLGLAARYVRAGFPRSARFTPTHAFLATWEQVGAYEEVKRGALPSGELNTFQAVL
130 140 150 160 170 180
240 250 260 270 280
pF1KE2 STDGSRSYALFLYQSGGMQWDVAQRSGK--------PVLMGFSSG--DGYFENSPLMSQP
..::: ::::::: ..:.:. .. : . :. .:: : : ..: .:
XP_005 ASDGSDSYALFLYPANGLQF-LGTRPKESYNVQLQLPARVGFCRGEADDLKSEGPYFSLT
190 200 210 220 230 240
290 300 310 320 330 340
pF1KE2 VWERYRPDRFLNSNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCS
:. . . :: :. :. ...
XP_005 STEQSVKNLYQLSNLGIPGVWAFHIGSTSPLDNVRPAAVGDLSAAHSSVPLGRSFSHATA
250 260 270 280 290 300
>>XP_005267463 (OMIM: 605399) PREDICTED: nidogen-2 isofo (1354 aa)
initn: 181 init1: 122 opt: 227 Z-score: 198.8 bits: 49.0 E(85289): 0.00025
Smith-Waterman score: 253; 27.1% identity (53.2% similar) in 295 aa overlap (39-313:3-270)
10 20 30 40 50 60
pF1KE2 VPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPSTAMHTRST
: :.: : .: .. .: . :..
XP_005 MEGDRVAGRPV-LSSLPVLLLLP--LLMLRAA
10 20
70 80 90 100 110 120
pF1KE2 AAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRDSLYFTDNG
: . :.. :::.: . :: ..... : .: . : :. . . . ..:: ::
XP_005 A----LHPDE---LFPHGESWGD-QLLQEGDDESSAVVKLANPLHFYEARFSNLYVGTNG
30 40 50 60 70 80
130 140 150 160 170 180
pF1KE2 QII---FP-ESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEYETFY
: :: :..: ...:. .:. .::: : : : ::: ..:.: .
XP_005 IISTQDFPRETQYVDYDFPTDFPA----------IAPFLADIDTSHGRGRVLYREDTS--
90 100 110 120
190 200 210 220 230
pF1KE2 GEHSLLVQQAESWIRK-ITNNGGYKARWALKVTWVNAHAYPA--QWTLGS---NTYQAIL
.. : ..: . .. . :. .:: .. :: . .: : ::.::.:
XP_005 ---PAVLGLAARYVRAGFPRSARFTPTHAFLATWEQVGAYEEVKRGALPSGELNTFQAVL
130 140 150 160 170 180
240 250 260 270 280
pF1KE2 STDGSRSYALFLYQSGGMQWDVAQRSGK--------PVLMGFSSG--DGYFENSPLMSQP
..::: ::::::: ..:.:. .. : . :. .:: : : ..: .:
XP_005 ASDGSDSYALFLYPANGLQF-LGTRPKESYNVQLQLPARVGFCRGEADDLKSEGPYFSLT
190 200 210 220 230 240
290 300 310 320 330 340
pF1KE2 VWERYRPDRFLNSNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCS
:. . . :: :. :. ...
XP_005 STEQSVKNLYQLSNLGIPGVWAFHIGSTSPLDNVRPAAVGDLSAAHSSVPLGRSFSHATA
250 260 270 280 290 300
>>NP_031387 (OMIM: 605399) nidogen-2 precursor [Homo sap (1375 aa)
initn: 228 init1: 122 opt: 227 Z-score: 198.7 bits: 49.0 E(85289): 0.00025
Smith-Waterman score: 253; 27.1% identity (53.2% similar) in 295 aa overlap (39-313:3-270)
10 20 30 40 50 60
pF1KE2 VPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPSTAMHTRST
: :.: : .: .. .: . :..
NP_031 MEGDRVAGRPV-LSSLPVLLLLP--LLMLRAA
10 20
70 80 90 100 110 120
pF1KE2 AAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRDSLYFTDNG
: . :.. :::.: . :: ..... : .: . : :. . . . ..:: ::
NP_031 A----LHPDE---LFPHGESWGD-QLLQEGDDESSAVVKLANPLHFYEARFSNLYVGTNG
30 40 50 60 70 80
130 140 150 160 170 180
pF1KE2 QII---FP-ESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEYETFY
: :: :..: ...:. .:. .::: : : : ::: ..:.: .
NP_031 IISTQDFPRETQYVDYDFPTDFPA----------IAPFLADIDTSHGRGRVLYREDTS--
90 100 110 120
190 200 210 220 230
pF1KE2 GEHSLLVQQAESWIRK-ITNNGGYKARWALKVTWVNAHAYPA--QWTLGS---NTYQAIL
.. : ..: . .. . :. .:: .. :: . .: : ::.::.:
NP_031 ---PAVLGLAARYVRAGFPRSARFTPTHAFLATWEQVGAYEEVKRGALPSGELNTFQAVL
130 140 150 160 170 180
240 250 260 270 280
pF1KE2 STDGSRSYALFLYQSGGMQWDVAQRSGK--------PVLMGFSSG--DGYFENSPLMSQP
..::: ::::::: ..:.:. .. : . :. .:: : : ..: .:
NP_031 ASDGSDSYALFLYPANGLQF-LGTRPKESYNVQLQLPARVGFCRGEADDLKSEGPYFSLT
190 200 210 220 230 240
290 300 310 320 330 340
pF1KE2 VWERYRPDRFLNSNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCS
:. . . :: :. :. ...
NP_031 STEQSVKNLYQLSNLGIPGVWAFHIGSTSPLDNVRPAAVGDLSAAHSSVPLGRSFSHATA
250 260 270 280 290 300
1176 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 20:21:14 2016 done: Mon Nov 7 20:21:16 2016
Total Scan time: 11.920 Total Display time: 0.410
Function used was FASTA [36.3.4 Apr, 2011]