Result of FASTA (omim) for
pF1KE2477
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2477, 604 aa
1>>>pF1KE2477 604 - 604 aa - 604 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7928+/-0.000424; mu= 16.8287+/- 0.026
mean_var=78.1483+/-15.602, 0's: 0 Z-trim(112.3): 16 B-trim: 1053 in 1/51
Lambda= 0.145082
statistics sampled from 21211 (21222) to 21211 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.616), E-opt: 0.2 (0.249), width: 16
Scan time: 8.710
The best scores are: opt bits E(85289)
NP_001014811 (OMIM: 604626) NADP-dependent malic e ( 604) 4032 854.0 0
NP_006671 (OMIM: 604626) NADP-dependent malic enzy ( 604) 4032 854.0 0
XP_005273774 (OMIM: 604626) PREDICTED: NADP-depend ( 604) 4032 854.0 0
NP_001155058 (OMIM: 604626) NADP-dependent malic e ( 604) 4032 854.0 0
XP_016872625 (OMIM: 604626) PREDICTED: NADP-depend ( 724) 4032 854.0 0
NP_002386 (OMIM: 154250) NADP-dependent malic enzy ( 572) 2824 601.1 3.3e-171
XP_016872626 (OMIM: 604626) PREDICTED: NADP-depend ( 467) 2781 592.1 1.4e-168
XP_016872627 (OMIM: 604626) PREDICTED: NADP-depend ( 403) 2644 563.4 5.4e-160
XP_011534138 (OMIM: 154250) PREDICTED: NADP-depend ( 497) 2550 543.7 5.4e-154
NP_002387 (OMIM: 154270) NAD-dependent malic enzym ( 584) 2191 468.6 2.6e-131
NP_001161807 (OMIM: 154270) NAD-dependent malic en ( 479) 1867 400.8 5.7e-111
>>NP_001014811 (OMIM: 604626) NADP-dependent malic enzym (604 aa)
initn: 4032 init1: 4032 opt: 4032 Z-score: 4560.9 bits: 854.0 E(85289): 0
Smith-Waterman score: 4032; 99.5% identity (99.8% similar) in 604 aa overlap (1-604:1-604)
10 20 30 40 50 60
pF1KE2 MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KGMAFTLEERLQLGIHGLIPPCFLGQDVQLLRIMGYYERQQSDLDKYIILMTLQDRNEKL
::::::::::::::::::::::::.::::::::: :::::::::::::::::::::::::
NP_001 KGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FNDDIQGTASVAVAGILAALRITNNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA
:::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::
NP_001 FNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
550 560 570 580 590 600
pF1KE2 VQTV
::::
NP_001 VQTV
>>NP_006671 (OMIM: 604626) NADP-dependent malic enzyme, (604 aa)
initn: 4032 init1: 4032 opt: 4032 Z-score: 4560.9 bits: 854.0 E(85289): 0
Smith-Waterman score: 4032; 99.5% identity (99.8% similar) in 604 aa overlap (1-604:1-604)
10 20 30 40 50 60
pF1KE2 MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KGMAFTLEERLQLGIHGLIPPCFLGQDVQLLRIMGYYERQQSDLDKYIILMTLQDRNEKL
::::::::::::::::::::::::.::::::::: :::::::::::::::::::::::::
NP_006 KGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FNDDIQGTASVAVAGILAALRITNNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA
:::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::
NP_006 FNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
550 560 570 580 590 600
pF1KE2 VQTV
::::
NP_006 VQTV
>>XP_005273774 (OMIM: 604626) PREDICTED: NADP-dependent (604 aa)
initn: 4032 init1: 4032 opt: 4032 Z-score: 4560.9 bits: 854.0 E(85289): 0
Smith-Waterman score: 4032; 99.5% identity (99.8% similar) in 604 aa overlap (1-604:1-604)
10 20 30 40 50 60
pF1KE2 MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KGMAFTLEERLQLGIHGLIPPCFLGQDVQLLRIMGYYERQQSDLDKYIILMTLQDRNEKL
::::::::::::::::::::::::.::::::::: :::::::::::::::::::::::::
XP_005 KGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FNDDIQGTASVAVAGILAALRITNNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA
:::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::
XP_005 FNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
550 560 570 580 590 600
pF1KE2 VQTV
::::
XP_005 VQTV
>>NP_001155058 (OMIM: 604626) NADP-dependent malic enzym (604 aa)
initn: 4032 init1: 4032 opt: 4032 Z-score: 4560.9 bits: 854.0 E(85289): 0
Smith-Waterman score: 4032; 99.5% identity (99.8% similar) in 604 aa overlap (1-604:1-604)
10 20 30 40 50 60
pF1KE2 MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KGMAFTLEERLQLGIHGLIPPCFLGQDVQLLRIMGYYERQQSDLDKYIILMTLQDRNEKL
::::::::::::::::::::::::.::::::::: :::::::::::::::::::::::::
NP_001 KGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 FNDDIQGTASVAVAGILAALRITNNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA
:::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::
NP_001 FNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
550 560 570 580 590 600
pF1KE2 VQTV
::::
NP_001 VQTV
>>XP_016872625 (OMIM: 604626) PREDICTED: NADP-dependent (724 aa)
initn: 4032 init1: 4032 opt: 4032 Z-score: 4559.7 bits: 854.0 E(85289): 0
Smith-Waterman score: 4032; 99.5% identity (99.8% similar) in 604 aa overlap (1-604:121-724)
10 20 30
pF1KE2 MGAALGTGTRLAPWPGRACGALPRWTPTAP
::::::::::::::::::::::::::::::
XP_016 THRPQLLTPPAPQRDRVDLSSPSSAGLPRTMGAALGTGTRLAPWPGRACGALPRWTPTAP
100 110 120 130 140 150
40 50 60 70 80 90
pF1KE2 AQGCHSKPGPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLGQDVQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
XP_016 AQGCHSKPGPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQL
160 170 180 190 200 210
100 110 120 130 140 150
pF1KE2 LRIMGYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGL
:::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRIMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGL
220 230 240 250 260 270
160 170 180 190 200 210
pF1KE2 TFRRPRGLFITIHDKGHLATMLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TFRRPRGLFITIHDKGHLATMLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLA
280 290 300 310 320 330
220 230 240 250 260 270
pF1KE2 LYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVHGKAYDDLLDEFMQAVTDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVHGKAYDDLLDEFMQAVTDK
340 350 360 370 380 390
280 290 300 310 320 330
pF1KE2 FGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITNNKLSNH
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
XP_016 FGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNH
400 410 420 430 440 450
340 350 360 370 380 390
pF1KE2 VFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFA
460 470 480 490 500 510
400 410 420 430 440 450
pF1KE2 QDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKAEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKAEC
520 530 540 550 560 570
460 470 480 490 500 510
pF1KE2 TAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGNNAYVFPGVALGVIAGGIRHIPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGNNAYVFPGVALGVIAGGIRHIPD
580 590 600 610 620 630
520 530 540 550 560 570
pF1KE2 EIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDYAYKHNLASYYPEPKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDYAYKHNLASYYPEPKD
640 650 660 670 680 690
580 590 600
pF1KE2 KEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQTV
::::::::::::::::::::::::::::::::::
XP_016 KEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQTV
700 710 720
>>NP_002386 (OMIM: 154250) NADP-dependent malic enzyme [ (572 aa)
initn: 2820 init1: 2820 opt: 2824 Z-score: 3194.7 bits: 601.1 E(85289): 3.3e-171
Smith-Waterman score: 2824; 71.3% identity (91.9% similar) in 567 aa overlap (37-603:2-568)
10 20 30 40 50 60
pF1KE2 TGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLNKGMAFT
.: : ..::: .:::::::: .:::
NP_002 MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFT
10 20 30
70 80 90 100 110 120
pF1KE2 LEERLQLGIHGLIPPCFLGQDVQLLRIMGYYERQQSDLDKYIILMTLQDRNEKLFYRVLT
:::: ::.::::.:: : .:..:.::.. .:. .::.:.:..:: ::::::::::::::
NP_002 LEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVLT
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 SDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNIKAVVVT
::.:::::::::::::::::.:.:.::.::::::::::.::.:..::.:::: :::.:::
NP_002 SDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVT
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 DGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGL
::::::::::::: :::::::::::::::::.:::.::::.:::::.:::::.:::::::
NP_002 DGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKDPLYIGL
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 KHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQ
...::.:. :::.:::::.::..:.:.:::::::::::.:::::::::::.:: ::::::
NP_002 RQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQ
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 GTASVAVAGILAALRITNNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKI
:::::::::.:::::::.::::.....::::::::.:::::.::::::::.:: .: .::
NP_002 GTASVAVAGLLAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKI
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 WMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQIL
:.:::::::::::. :..::: ::..: :...:: .:. .::::.::::::.:::.::::
NP_002 WLVDSKGLIVKGRASLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQIL
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 RDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQ
.:::.:.:::::::::::::::::.::.::..:.::.:::::::: ::: .:.:. :::
NP_002 KDMAAFNERPIIFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQ
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 GNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSL
:::.::::::::::.: :.:.: :.::: ::: :::.::..:: .:::::::.:::::::
NP_002 GNNSYVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSL
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE2 RIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQTV
.:: :.. ::... :. ::::..::::::: .:. :::.. : :.::.:....::
NP_002 KIAEKIVKDAYQEKTATVYPEPQNKEAFVRSQMYSTDYDQILPDCYSWPEEVQKIQTKVD
520 530 540 550 560 570
NP_002 Q
>>XP_016872626 (OMIM: 604626) PREDICTED: NADP-dependent (467 aa)
initn: 2781 init1: 2781 opt: 2781 Z-score: 3147.4 bits: 592.1 E(85289): 1.4e-168
Smith-Waterman score: 2781; 99.5% identity (100.0% similar) in 424 aa overlap (181-604:44-467)
160 170 180 190 200 210
pF1KE2 TFRRPRGLFITIHDKGHLATMLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLA
.:::::::::::::::::::::::::::::
XP_016 CINSTVGNPCSYDHSYKSKEAPEQARTFDPQAVVVTDGERILGLGDLGCYGMGIPVGKLA
20 30 40 50 60 70
220 230 240 250 260 270
pF1KE2 LYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVHGKAYDDLLDEFMQAVTDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVHGKAYDDLLDEFMQAVTDK
80 90 100 110 120 130
280 290 300 310 320 330
pF1KE2 FGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITNNKLSNH
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
XP_016 FGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNH
140 150 160 170 180 190
340 350 360 370 380 390
pF1KE2 VFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFA
200 210 220 230 240 250
400 410 420 430 440 450
pF1KE2 QDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKAEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKAEC
260 270 280 290 300 310
460 470 480 490 500 510
pF1KE2 TAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGNNAYVFPGVALGVIAGGIRHIPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGNNAYVFPGVALGVIAGGIRHIPD
320 330 340 350 360 370
520 530 540 550 560 570
pF1KE2 EIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDYAYKHNLASYYPEPKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDYAYKHNLASYYPEPKD
380 390 400 410 420 430
580 590 600
pF1KE2 KEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQTV
::::::::::::::::::::::::::::::::::
XP_016 KEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQTV
440 450 460
>>XP_016872627 (OMIM: 604626) PREDICTED: NADP-dependent (403 aa)
initn: 2644 init1: 2644 opt: 2644 Z-score: 2993.4 bits: 563.4 E(85289): 5.4e-160
Smith-Waterman score: 2644; 99.8% identity (100.0% similar) in 403 aa overlap (202-604:1-403)
180 190 200 210 220 230
pF1KE2 LNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVG
::::::::::::::::::::::::::::::
XP_016 MGIPVGKLALYTACGGVNPQQCLPVLLDVG
10 20 30
240 250 260 270 280 290
pF1KE2 TNNEELLRDPLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNNEELLRDPLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLL
40 50 60 70 80 90
300 310 320 330 340 350
pF1KE2 NKYRNKYCMFNDDIQGTASVAVAGILAALRITNNKLSNHVFVFQGAGEAAMGIAHLLVMA
::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::
XP_016 NKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMA
100 110 120 130 140 150
360 370 380 390 400 410
pF1KE2 LEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAI
160 170 180 190 200 210
420 430 440 450 460 470
pF1KE2 IGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPF
220 230 240 250 260 270
480 490 500 510 520 530
pF1KE2 KSVTLEDGKTFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSVTLEDGKTFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQ
280 290 300 310 320 330
540 550 560 570 580 590
pF1KE2 GRLYPPLSTIRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRLYPPLSTIRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDS
340 350 360 370 380 390
600
pF1KE2 YTWPKEAMNVQTV
:::::::::::::
XP_016 YTWPKEAMNVQTV
400
>>XP_011534138 (OMIM: 154250) PREDICTED: NADP-dependent (497 aa)
initn: 2550 init1: 2550 opt: 2550 Z-score: 2885.7 bits: 543.7 E(85289): 5.4e-154
Smith-Waterman score: 2550; 74.0% identity (93.7% similar) in 493 aa overlap (111-603:1-493)
90 100 110 120 130 140
pF1KE2 PCFLGQDVQLLRIMGYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPT
: ::::::::::::::::.:::::::::::
XP_011 MDLQDRNEKLFYRVLTSDIEKFMPIVYTPT
10 20 30
150 160 170 180 190 200
pF1KE2 VGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNIKAVVVTDGERILGLGDLGCY
::::::.:.:.::.::::::::::.::.:..::.:::: :::.::::::::::::::::
XP_011 VGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCN
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE2 GMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVHGKAYDDLL
:::::::::::::::::.:::.::::.:::::.:::::.:::::::...::.:. :::.:
XP_011 GMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFL
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE2 DEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAAL
::::.::..:.:.:::::::::::.:::::::::::.:: :::::::::::::::.::::
XP_011 DEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAAL
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE2 RITNNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRS
:::.::::.....::::::::.:::::.::::::::.:: .: .:::.:::::::::::.
XP_011 RITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRA
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE2 HLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIIFA
:..::: ::..: :...:: .:. .::::.::::::.:::.::::.:::.:.:::::::
XP_011 SLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFA
280 290 300 310 320 330
450 460 470 480 490 500
pF1KE2 LSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGNNAYVFPGVALGV
::::::::::.::.::..:.::.:::::::: ::: .:.:. ::::::.::::::::::
XP_011 LSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGV
340 350 360 370 380 390
510 520 530 540 550 560
pF1KE2 IAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDYAYKHN
.: :.:.: :.::: ::: :::.::..:: .:::::::.:::::::.:: :.. ::...
XP_011 VACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEK
400 410 420 430 440 450
570 580 590 600
pF1KE2 LASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQTV
:. ::::..::::::: .:. :::.. : :.::.:....::
XP_011 TATVYPEPQNKEAFVRSQMYSTDYDQILPDCYSWPEEVQKIQTKVDQ
460 470 480 490
>>NP_002387 (OMIM: 154270) NAD-dependent malic enzyme, m (584 aa)
initn: 2137 init1: 1427 opt: 2191 Z-score: 2478.5 bits: 468.6 E(85289): 2.6e-131
Smith-Waterman score: 2191; 55.9% identity (82.7% similar) in 560 aa overlap (42-598:17-576)
20 30 40 50 60 70
pF1KE2 APWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLNKGMAFTLEERL
: . .:..: . ::. ::::::::.::
NP_002 MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQ
10 20 30 40
80 90 100 110 120 130
pF1KE2 QLGIHGLIPPCFLGQDVQLLRIMGYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEK
.::..::.:: . ::.: ::. ... : :.::: .: .:.::::::::.: .:.:.
NP_002 MLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIES
50 60 70 80 90 100
140 150 160 170 180 190
pF1KE2 FMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNIKAVVVTDGERI
.:::::::::::::..:: ::::.::::.: :.::. .....:::...:::::::::::
NP_002 LMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERI
110 120 130 140 150 160
200 210 220 230 240 250
pF1KE2 LGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRV
::::::: :::::::::: :::::.:. :..:::: .::::.: ::.::.:.:: ..:
NP_002 LGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRD
170 180 190 200 210 220
260 270 280 290 300 310
pF1KE2 HGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASV
. . ::::.::::.:.::..: : :::::::.: ::::.: :::.::: :::::::::.:
NP_002 RTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAV
230 240 250 260 270 280
320 330 340 350 360 370
pF1KE2 AVAGILAALRITNNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDS
:.::.::: .. .. .:.: ..: ::::::.:::.:.::.. ..:. . :: .:::: :.
NP_002 ALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDK
290 300 310 320 330 340
380 390 400 410 420
pF1KE2 KGLIVKGR-SHLNHEKEMFAQDHPEV--NSLEEVVRLVKPTAIIGVAAIAGAFTEQILRD
::.:::: .... .: :... :: ...:..: ..::..:::::. . :: ...:
NP_002 YGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRA
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE2 MASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGN
:::..:::.::::::::..::::::. : .:::: .::::::: : : ::..: :::::
NP_002 MASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGN
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE2 NAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRI
:.:.::::::.:: . ::: : .:: .:. .........:.::::::::..:..::. :
NP_002 NVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINI
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE2 AIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQTV
:::: .: : ...: ::::.:: .:. .. .:::. : : ::. :
NP_002 AIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE
530 540 550 560 570 580
604 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 20:35:05 2016 done: Mon Nov 7 20:35:06 2016
Total Scan time: 8.710 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]