Result of FASTA (ccds) for pF1KE2480
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE2480, 1453 aa
  1>>>pF1KE2480 1453 - 1453 aa - 1453 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.5279+/-0.00128; mu= 16.8045+/- 0.076
 mean_var=81.2895+/-16.229, 0's: 0 Z-trim(101.7): 37  B-trim: 148 in 1/49
 Lambda= 0.142252
 statistics sampled from 6616 (6632) to 6616 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.544), E-opt: 0.2 (0.204), width:  16
 Scan time:  4.690

The best scores are:                                      opt bits E(32554)
CCDS32123.1 MLH3 gene_id:27030|Hs108|chr14         (1453) 9549 1970.6       0
CCDS9837.1 MLH3 gene_id:27030|Hs108|chr14          (1429) 7959 1644.3       0
CCDS2663.1 MLH1 gene_id:4292|Hs108|chr3            ( 756)  392 91.3 1.2e-17
CCDS46473.1 PMS1 gene_id:5378|Hs108|chr2           ( 770)  308 74.1 1.8e-12
CCDS2302.1 PMS1 gene_id:5378|Hs108|chr2            ( 932)  308 74.1 2.2e-12


>>CCDS32123.1 MLH3 gene_id:27030|Hs108|chr14              (1453 aa)
 initn: 9549 init1: 9549 opt: 9549  Z-score: 10582.1  bits: 1970.6 E(32554):    0
Smith-Waterman score: 9549; 99.9% identity (99.9% similar) in 1453 aa overlap (1-1453:1-1453)

               10        20        30        40        50        60
pF1KE2 MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETFQVQVIDNGFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETFQVQVIDNGFG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 MGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 MGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 VKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRKCMDPRLEFEKVRQRIEALSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 VKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRKCMDPRLEFEKVRQRIEALSL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 MHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLGKSQKLREISFKYKEFELSGYIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 MHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLGKSQKLREISFKYKEFELSGYIS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKESIICKPKNGPTSRQMNSSLRHRSTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 SEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKESIICKPKNGPTSRQMNSSLRHRSTP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 ELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFCIQEGVKMFLKQEKLFVELSGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 ELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFCIQEGVKMFLKQEKLFVELSGE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 DIKEFSEDNGFSLFDATLQKRVTSDERSNFQEACNNILDSYEMFNLQSKAVKRKTTAENV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 DIKEFSEDNGFSLFDATLQKRVTSDERSNFQEACNNILDSYEMFNLQSKAVKRKTTAENV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 NTQSSRDSEATRKNTNDAFLYIYESGGPGHSKMTEPSLQNKDSSCSESKMLEQETIVASE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 NTQSSRDSEATRKNTNDAFLYIYESGGPGHSKMTEPSLQNKDSSCSESKMLEQETIVASE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 AGENEKHKKSFLEHSSLENPCGTSLEMFLSPFQTPCHFEESGQDLEIWKESTTVNGMAAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 AGENEKHKKSFLEHSSLENPCGTSLEMFLSPFQTPCHFEESGQDLEIWKESTTVNGMAAN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 ILKNNRIQNQPKRFKDATEVGCQPLPFATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 ILKNNRIQNQPKRFKDATEVGCQPLPFATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGR
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 VKLCSTGFITHVVQNEKTKSTETEHSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 VKLCSTGFITHVVQNEKTKSTETEHSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLAS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 TLSKESGQLPNKKNCRTNISYGLENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPWY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 TLSKESGQLPNKKNCRTNISYGLENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPWY
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 RHVSNDSRKTDKLIGFSKPIVRKKLSLSSQLGSLEKFKRQYGKVENPLDTEVEESNGVTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 RHVSNDSRKTDKLIGFSKPIVRKKLSLSSQLGSLEKFKRQYGKVENPLDTEVEESNGVTT
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 NLSLQVEPDILLKDKNRLENSDVCKITTMEHSDSDSSCQPASHILDSEKFPFSKDEDCLE
       :::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::
CCDS32 NLSLQVEPDILLKDKNRLENSDVCKITTMEHSDSDSSCQPASHILNSEKFPFSKDEDCLE
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 QQMLSLRESPMTLKELSLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELP
       ::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 QQMPSLRESPMTLKELSLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELP
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 NSDSSRKDSKLCSVLTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 NSDSSRKDSKLCSVLTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTT
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE2 ENCVISETPLVLPYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGIC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 ENCVISETPLVLPYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGIC
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE2 FQSEESKARACSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 FQSEESKARACSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTK
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE2 DLTTVAVDVVLENGSQYRCQPFRSDLVLPFLPRARAERTVMRQDNRDTVDDTVSSESLQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 DLTTVAVDVVLENGSQYRCQPFRSDLVLPFLPRARAERTVMRQDNRDTVDDTVSSESLQS
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE2 LFSEWDNPVFARYPEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNKFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 LFSEWDNPVFARYPEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNKFI
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE2 ACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 ACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLI
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KE2 PPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 PPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGR
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KE2 STVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 STVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRL
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KE2 IEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAECDTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 IEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAECDTR
             1390      1400      1410      1420      1430      1440

             1450   
pF1KE2 QSLQQSMPPCEPP
       :::::::::::::
CCDS32 QSLQQSMPPCEPP
             1450   

>>CCDS9837.1 MLH3 gene_id:27030|Hs108|chr14               (1429 aa)
 initn: 9384 init1: 7959 opt: 7959  Z-score: 8818.7  bits: 1644.3 E(32554):    0
Smith-Waterman score: 9340; 98.2% identity (98.3% similar) in 1453 aa overlap (1-1453:1-1429)

               10        20        30        40        50        60
pF1KE2 MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETFQVQVIDNGFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETFQVQVIDNGFG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 MGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 MGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 VKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRKCMDPRLEFEKVRQRIEALSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 VKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRKCMDPRLEFEKVRQRIEALSL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 MHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLGKSQKLREISFKYKEFELSGYIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 MHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLGKSQKLREISFKYKEFELSGYIS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 SEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKESIICKPKNGPTSRQMNSSLRHRSTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 SEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKESIICKPKNGPTSRQMNSSLRHRSTP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 ELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFCIQEGVKMFLKQEKLFVELSGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 ELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFCIQEGVKMFLKQEKLFVELSGE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 DIKEFSEDNGFSLFDATLQKRVTSDERSNFQEACNNILDSYEMFNLQSKAVKRKTTAENV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 DIKEFSEDNGFSLFDATLQKRVTSDERSNFQEACNNILDSYEMFNLQSKAVKRKTTAENV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 NTQSSRDSEATRKNTNDAFLYIYESGGPGHSKMTEPSLQNKDSSCSESKMLEQETIVASE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 NTQSSRDSEATRKNTNDAFLYIYESGGPGHSKMTEPSLQNKDSSCSESKMLEQETIVASE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 AGENEKHKKSFLEHSSLENPCGTSLEMFLSPFQTPCHFEESGQDLEIWKESTTVNGMAAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 AGENEKHKKSFLEHSSLENPCGTSLEMFLSPFQTPCHFEESGQDLEIWKESTTVNGMAAN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 ILKNNRIQNQPKRFKDATEVGCQPLPFATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 ILKNNRIQNQPKRFKDATEVGCQPLPFATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGR
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE2 VKLCSTGFITHVVQNEKTKSTETEHSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 VKLCSTGFITHVVQNEKTKSTETEHSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLAS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE2 TLSKESGQLPNKKNCRTNISYGLENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPWY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 TLSKESGQLPNKKNCRTNISYGLENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPWY
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE2 RHVSNDSRKTDKLIGFSKPIVRKKLSLSSQLGSLEKFKRQYGKVENPLDTEVEESNGVTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 RHVSNDSRKTDKLIGFSKPIVRKKLSLSSQLGSLEKFKRQYGKVENPLDTEVEESNGVTT
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE2 NLSLQVEPDILLKDKNRLENSDVCKITTMEHSDSDSSCQPASHILDSEKFPFSKDEDCLE
       :::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::
CCDS98 NLSLQVEPDILLKDKNRLENSDVCKITTMEHSDSDSSCQPASHILNSEKFPFSKDEDCLE
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE2 QQMLSLRESPMTLKELSLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELP
       ::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 QQMPSLRESPMTLKELSLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELP
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE2 NSDSSRKDSKLCSVLTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 NSDSSRKDSKLCSVLTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTT
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE2 ENCVISETPLVLPYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGIC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 ENCVISETPLVLPYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGIC
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE2 FQSEESKARACSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 FQSEESKARACSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTK
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE2 DLTTVAVDVVLENGSQYRCQPFRSDLVLPFLPRARAERTVMRQDNRDTVDDTVSSESLQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 DLTTVAVDVVLENGSQYRCQPFRSDLVLPFLPRARAERTVMRQDNRDTVDDTVSSESLQS
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE2 LFSEWDNPVFARYPEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNKFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 LFSEWDNPVFARYPEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNKFI
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE2 ACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLI
       ::::::::::::::                        ::::::::::::::::::::::
CCDS98 ACLMSTKTEENGEA------------------------DSYEKQQAQGSGRKKLLSSTLI
             1210                              1220      1230      

             1270      1280      1290      1300      1310      1320
pF1KE2 PPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 PPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGR
       1240      1250      1260      1270      1280      1290      

             1330      1340      1350      1360      1370      1380
pF1KE2 STVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 STVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRL
       1300      1310      1320      1330      1340      1350      

             1390      1400      1410      1420      1430      1440
pF1KE2 IEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAECDTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 IEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAECDTR
       1360      1370      1380      1390      1400      1410      

             1450   
pF1KE2 QSLQQSMPPCEPP
       :::::::::::::
CCDS98 QSLQQSMPPCEPP
       1420         

>>CCDS2663.1 MLH1 gene_id:4292|Hs108|chr3                 (756 aa)
 initn: 217 init1: 161 opt: 392  Z-score: 430.6  bits: 91.3 E(32554): 1.2e-17
Smith-Waterman score: 414; 26.4% identity (57.1% similar) in 508 aa overlap (1-489:7-475)

                     10        20        30        40        50    
pF1KE2       MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETFQ-VQ
             .:. :.  :  .. .: .:.  .. ..:.  : .::..  . : :.   .. .:
CCDS26 MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQ
               10        20        30        40        50        60

            60        70        80        90       100       110   
pF1KE2 VIDNGFGMGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKK
       . ::: :. ..:.. : .:. ::: .: .:: .   :::::::::.:. .:  : :..: 
CCDS26 IQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAH-VTITTKT
               70        80        90       100       110          

           120       130       140       150       160        170  
pF1KE2 NRTMKTFVKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRKCM-DPRLEFEKVR
            ..   ...:: :::     . .. :: .:: .:::.. .::: . .:  :. :. 
CCDS26 ADGKCAYRASYSDGK-LKAPPKPCA-GNQGTQITVEDLFYNIATRRKALKNPSEEYGKIL
     120       130        140        150       160       170       

            180       190        200       210       220       230 
pF1KE2 QRIEALSLMHPSISFSLRND-VSGSMVLQLPKTKDVCSRFCQIYGLGKSQKLREISFKYK
       . .   :. . .::::....  . . :  ::... : . . .:.: . :..: ::. . :
CCDS26 EVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTV-DNIRSIFGNAVSRELIEIGCEDK
       180       190       200       210        220       230      

               240         250       260       270       280       
pF1KE2 E--FELSGYISSEAHYN--KNMQFLFVNKRLVLRTKLHKLIDFLLRKESIICKPKNGPTS
          :...::::. :.:.  : . .::.:.:::  :.:.: :. .         :::    
CCDS26 TLAFKMNGYISN-ANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYL----PKN----
        240        250       260       270       280               

       290       300       310       320       330       340       
pF1KE2 RQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFCIQEGV---
                 . : ::    :. :    . :: ..:.:  ..: . ...:  .:. .   
CCDS26 ----------THPFLYLSLEISPQ----NVDVNVHPTKHEVHFLHEESILERVQQHIESK
                 290       300           310       320       330   

                 350         360       370       380       390     
pF1KE2 -------KMFLKQEKL--FVELSGEDIKEFSEDNGFSLFDATLQKRVTSDERSNFQEACN
              .:.. :  :  ..  ::: .:  .  .. :   .. .  . .  :.. .:   
CCDS26 LLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSRE---
           340       350       360       370       380       390   

         400       410       420       430       440       450     
pF1KE2 NILDSYEMFNLQSKAVKRKTTAENVNTQSSRDSEATRKNTNDAFLYIYESGGPGHSKMTE
       . ::..    ::  .   ..  . . :... :  . :   .:  .   :  .:..    .
CCDS26 QKLDAF----LQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEM--LELPAPAEVAAKN
                  400       410       420       430         440    

         460       470       480       490       500       510     
pF1KE2 PSLQNKDSSCSESKMLEQETIVASEAGENEKHKKSFLEHSSLENPCGTSLEMFLSPFQTP
        ::.. :.. . :.: :..  ..:.    ..:..                          
CCDS26 QSLEG-DTTKGTSEMSEKRGPTSSNP--RKRHREDSDVEMVEDDSRKEMTAACTPRRRII
           450       460         470       480       490       500 

         520       530       540       550       560       570     
pF1KE2 CHFEESGQDLEIWKESTTVNGMAANILKNNRIQNQPKRFKDATEVGCQPLPFATTLWGVH
                                                                   
CCDS26 NLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFY
             510       520       530       540       550       560 

>>CCDS46473.1 PMS1 gene_id:5378|Hs108|chr2                (770 aa)
 initn: 251 init1: 152 opt: 308  Z-score: 337.3  bits: 74.1 E(32554): 1.8e-12
Smith-Waterman score: 361; 25.5% identity (53.1% similar) in 631 aa overlap (13-587:12-597)

               10        20        30        40        50          
pF1KE2 MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETF-QVQVIDNGF
                   : :.  :.:. . :.::  ::.:: :  : :...   : ...: ::: 
CCDS46  MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGE
                10        20        30        40        50         

      60        70        80        90       100       110         
pF1KE2 GMGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKT
       :. . :.  .. .:.::: .: .::::   ::::::::..:  .: ..  .     ...:
CCDS46 GIKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFST
      60        70        80        90       100       110         

     120       130       140       150              160       170  
pF1KE2 FVKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRR-------KCMDPRLEFEKVR
          :  ::. :.   . .   . :::::.  :: .::::.       :: :   :..:..
CCDS46 QYVLDGSGHILSQKPSHL---GQGTTVTALRLFKNLPVRKQFYSTAKKCKD---EIKKIQ
     120       130          140       150       160          170   

            180       190       200       210       220       230  
pF1KE2 QRIEALSLMHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLGKSQKLREISFKYKE
       . . ......:.. . . ..   ... :  ...:    . .. : .  ....  ::.:. 
CCDS46 DLLMSFGILKPDLRIVFVHN--KAVIWQKSRVSDHKMALMSVLGTAVMNNME--SFQYHS
           180       190         200       210       220           

                240              250       260       270       280 
pF1KE2 FE----LSGYISS-EAHYN------KNMQFLFVNKRLVLRTKLHKLIDFLLRKESIICKP
        :    :::.. . .: ..       . .:.:.:.: : .  . :::    .. .. :  
CCDS46 EESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIR---HHYNLKC--
     230       240       250       260       270          280      

             290       300       310       320       330       340 
pF1KE2 KNGPTSRQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFCIQ
               .. : :      :: .. ....    . :: . : :. . .:: ...:. . 
CCDS46 --------LKESTR------LYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIAL-
                  290             300       310       320          

             350       360       370          380       390        
pF1KE2 EGVKMFLKQEKLFVELSGEDIKEFSEDNG---FSLFDATLQKRVTSDERSNFQEAC----
                :.:..   :   .  : .:.    :  : .:.: . .:   :  :.     
CCDS46 ---------ENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNY
              330       340       350       360       370       380

          400        410       420               430         440   
pF1KE2 NNILDSYEMF-NLQSKAVKRKTTAENVNTQSSR--------DSEATR--KNTNDAFLYIY
       .:.  :   : : . .  . :.: . .: : :         .:: .   :::..::  : 
CCDS46 SNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDIS
              390       400       410       420       430       440

           450       460       470       480       490             
pF1KE2 ESGGPGHSKMTEPSLQNKDSSCSESKMLEQETIVASEAGENEKHKKSFLEHSS-------
        :.   ....:: :     :: ....  . .    .:.::::.  .. ::.::       
CCDS46 MSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEE--EAGLENSSEISADEW
              450       460       470       480         490        

             500         510        520       530       540        
pF1KE2 -----LENPCGTSLE--MFLSPFQT-PCHFEESGQDLEIWKESTTVNGMAANILKNNRIQ
            :.:  : ..:   .: : .. ::.   :...  :  :. ..:  . :  :.: :.
CCDS46 SRGNILKNSVGENIEPVKILVPEKSLPCKV--SNNNYPI-PEQMNLNEDSCNK-KSNVID
      500       510       520         530        540        550    

      550           560       570       580       590       600    
pF1KE2 NQPKRFKD----ATEVGCQPLPFATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGRVKLC
       :.  .       ...:  .:.  .. .   :  :   :. : :                 
CCDS46 NKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSE
          560       570       580       590       600       610    

          610       620       630       640       650       660    
pF1KE2 STGFITHVVQNEKTKSTETEHSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLASTLSK
                                                                   
CCDS46 EEKLNLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIE
          620       630       640       650       660       670    

>>CCDS2302.1 PMS1 gene_id:5378|Hs108|chr2                 (932 aa)
 initn: 251 init1: 152 opt: 308  Z-score: 335.9  bits: 74.1 E(32554): 2.2e-12
Smith-Waterman score: 361; 25.5% identity (53.1% similar) in 631 aa overlap (13-587:12-597)

               10        20        30        40        50          
pF1KE2 MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETF-QVQVIDNGF
                   : :.  :.:. . :.::  ::.:: :  : :...   : ...: ::: 
CCDS23  MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGE
                10        20        30        40        50         

      60        70        80        90       100       110         
pF1KE2 GMGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKT
       :. . :.  .. .:.::: .: .::::   ::::::::..:  .: ..  .     ...:
CCDS23 GIKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFST
      60        70        80        90       100       110         

     120       130       140       150              160       170  
pF1KE2 FVKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRR-------KCMDPRLEFEKVR
          :  ::. :.   . .   . :::::.  :: .::::.       :: :   :..:..
CCDS23 QYVLDGSGHILSQKPSHL---GQGTTVTALRLFKNLPVRKQFYSTAKKCKD---EIKKIQ
     120       130          140       150       160          170   

            180       190       200       210       220       230  
pF1KE2 QRIEALSLMHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLGKSQKLREISFKYKE
       . . ......:.. . . ..   ... :  ...:    . .. : .  ....  ::.:. 
CCDS23 DLLMSFGILKPDLRIVFVHN--KAVIWQKSRVSDHKMALMSVLGTAVMNNME--SFQYHS
           180       190         200       210       220           

                240              250       260       270       280 
pF1KE2 FE----LSGYISS-EAHYN------KNMQFLFVNKRLVLRTKLHKLIDFLLRKESIICKP
        :    :::.. . .: ..       . .:.:.:.: : .  . :::    .. .. :  
CCDS23 EESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIR---HHYNLKC--
     230       240       250       260       270          280      

             290       300       310       320       330       340 
pF1KE2 KNGPTSRQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFCIQ
               .. : :      :: .. ....    . :: . : :. . .:: ...:. . 
CCDS23 --------LKESTR------LYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIAL-
                  290             300       310       320          

             350       360       370          380       390        
pF1KE2 EGVKMFLKQEKLFVELSGEDIKEFSEDNG---FSLFDATLQKRVTSDERSNFQEAC----
                :.:..   :   .  : .:.    :  : .:.: . .:   :  :.     
CCDS23 ---------ENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNY
              330       340       350       360       370       380

          400        410       420               430         440   
pF1KE2 NNILDSYEMF-NLQSKAVKRKTTAENVNTQSSR--------DSEATR--KNTNDAFLYIY
       .:.  :   : : . .  . :.: . .: : :         .:: .   :::..::  : 
CCDS23 SNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDIS
              390       400       410       420       430       440

           450       460       470       480       490             
pF1KE2 ESGGPGHSKMTEPSLQNKDSSCSESKMLEQETIVASEAGENEKHKKSFLEHSS-------
        :.   ....:: :     :: ....  . .    .:.::::.  .. ::.::       
CCDS23 MSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEE--EAGLENSSEISADEW
              450       460       470       480         490        

             500         510        520       530       540        
pF1KE2 -----LENPCGTSLE--MFLSPFQT-PCHFEESGQDLEIWKESTTVNGMAANILKNNRIQ
            :.:  : ..:   .: : .. ::.   :...  :  :. ..:  . :  :.: :.
CCDS23 SRGNILKNSVGENIEPVKILVPEKSLPCKV--SNNNYPI-PEQMNLNEDSCNK-KSNVID
      500       510       520         530        540        550    

      550           560       570       580       590       600    
pF1KE2 NQPKRFKD----ATEVGCQPLPFATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGRVKLC
       :.  .       ...:  .:.  .. .   :  :   :. : :                 
CCDS23 NKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSE
          560       570       580       590       600       610    

          610       620       630       640       650       660    
pF1KE2 STGFITHVVQNEKTKSTETEHSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLASTLSK
                                                                   
CCDS23 EEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSN
          620       630       640       650       660       670    




1453 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Mon Nov  7 20:44:45 2016 done: Mon Nov  7 20:44:46 2016
 Total Scan time:  4.690 Total Display time:  0.170

Function used was FASTA [36.3.4 Apr, 2011]
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