FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2487, 684 aa 1>>>pF1KE2487 684 - 684 aa - 684 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7051+/-0.00035; mu= 18.0636+/- 0.022 mean_var=81.1505+/-16.172, 0's: 0 Z-trim(114.4): 16 B-trim: 0 in 0/56 Lambda= 0.142373 statistics sampled from 24265 (24280) to 24265 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.285), width: 16 Scan time: 8.620 The best scores are: opt bits E(85289) NP_068602 (OMIM: 271245,606075,607459,609286,61613 ( 684) 4618 958.7 0 NP_001157284 (OMIM: 271245,606075,607459,609286,61 ( 582) 3925 816.3 0 XP_016871926 (OMIM: 271245,606075,607459,609286,61 ( 230) 1542 326.6 6.7e-89 NP_001157285 (OMIM: 271245,606075,607459,609286,61 ( 230) 1542 326.6 6.7e-89 XP_011538277 (OMIM: 271245,606075,607459,609286,61 ( 230) 1542 326.6 6.7e-89 NP_001157286 (OMIM: 271245,606075,607459,609286,61 ( 128) 849 184.1 2.9e-46 >>NP_068602 (OMIM: 271245,606075,607459,609286,616138) t (684 aa) initn: 4618 init1: 4618 opt: 4618 Z-score: 5124.8 bits: 958.7 E(85289): 0 Smith-Waterman score: 4618; 100.0% identity (100.0% similar) in 684 aa overlap (1-684:1-684) 10 20 30 40 50 60 pF1KE2 MWVLLRSGYPLRILLPLRGEWMGRRGLPRNLAPGPPRRRYRKETLQALDMPVLPVTATEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 MWVLLRSGYPLRILLPLRGEWMGRRGLPRNLAPGPPRRRYRKETLQALDMPVLPVTATEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RQYLRGHGIPFQDGHSCLRALSPFAESSQLKGQTGVTTSFSLFIDKTTGHFLCMTSLAEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 RQYLRGHGIPFQDGHSCLRALSPFAESSQLKGQTGVTTSFSLFIDKTTGHFLCMTSLAEG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SWEDFQASVEGRGDGAREGFLLSKAPEFEDSEEVRRIWNRAIPLWELPDQEEVQLADTMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 SWEDFQASVEGRGDGAREGFLLSKAPEFEDSEEVRRIWNRAIPLWELPDQEEVQLADTMF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GLTKVTDDTLKRFSVRYLRPARSLVFPWFSPGGSGLRGLKLLEAKCQGDGVSYEETTIPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 GLTKVTDDTLKRFSVRYLRPARSLVFPWFSPGGSGLRGLKLLEAKCQGDGVSYEETTIPR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 PSAYHNLFGLPLISRRDAEVVLTSRELDSLALNQSTGLPTLTLPRGTTCLPPALLPYLEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 PSAYHNLFGLPLISRRDAEVVLTSRELDSLALNQSTGLPTLTLPRGTTCLPPALLPYLEQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FRRIVFWLGDDLRSWEAAKLFARKLNPKRCFLVRPGDQQPRPLEALNGGFNLSRILRTAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 FRRIVFWLGDDLRSWEAAKLFARKLNPKRCFLVRPGDQQPRPLEALNGGFNLSRILRTAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 PAWHKSIVSFRQLREEVLGELSNVEQAAGLRWSRFPDLNRILKGHRKGELTVFTGPTGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 PAWHKSIVSFRQLREEVLGELSNVEQAAGLRWSRFPDLNRILKGHRKGELTVFTGPTGSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 KTTFISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 KTTFISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFED 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LPLYFMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 LPLYFMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 VFRKFATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 VFRKFATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 RYLQVSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 RYLQVSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGAT 610 620 630 640 650 660 670 680 pF1KE2 TQNSEICSGQAPTPDQPDTSKRSK :::::::::::::::::::::::: NP_068 TQNSEICSGQAPTPDQPDTSKRSK 670 680 >>NP_001157284 (OMIM: 271245,606075,607459,609286,616138 (582 aa) initn: 3925 init1: 3925 opt: 3925 Z-score: 4356.5 bits: 816.3 E(85289): 0 Smith-Waterman score: 3925; 99.8% identity (100.0% similar) in 580 aa overlap (1-580:1-580) 10 20 30 40 50 60 pF1KE2 MWVLLRSGYPLRILLPLRGEWMGRRGLPRNLAPGPPRRRYRKETLQALDMPVLPVTATEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWVLLRSGYPLRILLPLRGEWMGRRGLPRNLAPGPPRRRYRKETLQALDMPVLPVTATEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RQYLRGHGIPFQDGHSCLRALSPFAESSQLKGQTGVTTSFSLFIDKTTGHFLCMTSLAEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQYLRGHGIPFQDGHSCLRALSPFAESSQLKGQTGVTTSFSLFIDKTTGHFLCMTSLAEG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SWEDFQASVEGRGDGAREGFLLSKAPEFEDSEEVRRIWNRAIPLWELPDQEEVQLADTMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWEDFQASVEGRGDGAREGFLLSKAPEFEDSEEVRRIWNRAIPLWELPDQEEVQLADTMF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GLTKVTDDTLKRFSVRYLRPARSLVFPWFSPGGSGLRGLKLLEAKCQGDGVSYEETTIPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLTKVTDDTLKRFSVRYLRPARSLVFPWFSPGGSGLRGLKLLEAKCQGDGVSYEETTIPR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 PSAYHNLFGLPLISRRDAEVVLTSRELDSLALNQSTGLPTLTLPRGTTCLPPALLPYLEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSAYHNLFGLPLISRRDAEVVLTSRELDSLALNQSTGLPTLTLPRGTTCLPPALLPYLEQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FRRIVFWLGDDLRSWEAAKLFARKLNPKRCFLVRPGDQQPRPLEALNGGFNLSRILRTAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRRIVFWLGDDLRSWEAAKLFARKLNPKRCFLVRPGDQQPRPLEALNGGFNLSRILRTAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 PAWHKSIVSFRQLREEVLGELSNVEQAAGLRWSRFPDLNRILKGHRKGELTVFTGPTGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAWHKSIVSFRQLREEVLGELSNVEQAAGLRWSRFPDLNRILKGHRKGELTVFTGPTGSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 KTTFISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTTFISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFED 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LPLYFMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPLYFMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 VFRKFATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGK ::::::::::::::::::::::::::::::::::::::.: NP_001 VFRKFATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKVSGL 550 560 570 580 610 620 630 640 650 660 pF1KE2 RYLQVSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGAT >>XP_016871926 (OMIM: 271245,606075,607459,609286,616138 (230 aa) initn: 1542 init1: 1542 opt: 1542 Z-score: 1717.0 bits: 326.6 E(85289): 6.7e-89 Smith-Waterman score: 1542; 100.0% identity (100.0% similar) in 230 aa overlap (455-684:1-230) 430 440 450 460 470 480 pF1KE2 ISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFEDLPLY :::::::::::::::::::::::::::::: XP_016 MLTQFAEGRLEDQLDKYDHWADRFEDLPLY 10 20 30 490 500 510 520 530 540 pF1KE2 FMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIGVFRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIGVFRK 40 50 60 70 80 90 550 560 570 580 590 600 pF1KE2 FATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQ 100 110 120 130 140 150 610 620 630 640 650 660 pF1KE2 VSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGATTQNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGATTQNS 160 170 180 190 200 210 670 680 pF1KE2 EICSGQAPTPDQPDTSKRSK :::::::::::::::::::: XP_016 EICSGQAPTPDQPDTSKRSK 220 230 >>NP_001157285 (OMIM: 271245,606075,607459,609286,616138 (230 aa) initn: 1542 init1: 1542 opt: 1542 Z-score: 1717.0 bits: 326.6 E(85289): 6.7e-89 Smith-Waterman score: 1542; 100.0% identity (100.0% similar) in 230 aa overlap (455-684:1-230) 430 440 450 460 470 480 pF1KE2 ISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFEDLPLY :::::::::::::::::::::::::::::: NP_001 MLTQFAEGRLEDQLDKYDHWADRFEDLPLY 10 20 30 490 500 510 520 530 540 pF1KE2 FMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIGVFRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIGVFRK 40 50 60 70 80 90 550 560 570 580 590 600 pF1KE2 FATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQ 100 110 120 130 140 150 610 620 630 640 650 660 pF1KE2 VSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGATTQNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGATTQNS 160 170 180 190 200 210 670 680 pF1KE2 EICSGQAPTPDQPDTSKRSK :::::::::::::::::::: NP_001 EICSGQAPTPDQPDTSKRSK 220 230 >>XP_011538277 (OMIM: 271245,606075,607459,609286,616138 (230 aa) initn: 1542 init1: 1542 opt: 1542 Z-score: 1717.0 bits: 326.6 E(85289): 6.7e-89 Smith-Waterman score: 1542; 100.0% identity (100.0% similar) in 230 aa overlap (455-684:1-230) 430 440 450 460 470 480 pF1KE2 ISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFEDLPLY :::::::::::::::::::::::::::::: XP_011 MLTQFAEGRLEDQLDKYDHWADRFEDLPLY 10 20 30 490 500 510 520 530 540 pF1KE2 FMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIGVFRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIGVFRK 40 50 60 70 80 90 550 560 570 580 590 600 pF1KE2 FATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQ 100 110 120 130 140 150 610 620 630 640 650 660 pF1KE2 VSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGATTQNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGATTQNS 160 170 180 190 200 210 670 680 pF1KE2 EICSGQAPTPDQPDTSKRSK :::::::::::::::::::: XP_011 EICSGQAPTPDQPDTSKRSK 220 230 >>NP_001157286 (OMIM: 271245,606075,607459,609286,616138 (128 aa) initn: 874 init1: 849 opt: 849 Z-score: 951.5 bits: 184.1 E(85289): 2.9e-46 Smith-Waterman score: 849; 99.2% identity (100.0% similar) in 126 aa overlap (455-580:1-126) 430 440 450 460 470 480 pF1KE2 ISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFEDLPLY :::::::::::::::::::::::::::::: NP_001 MLTQFAEGRLEDQLDKYDHWADRFEDLPLY 10 20 30 490 500 510 520 530 540 pF1KE2 FMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIGVFRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIGVFRK 40 50 60 70 80 90 550 560 570 580 590 600 pF1KE2 FATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQ ::::::::::::::::::::::::::::::::::.: NP_001 FATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKVSGL 100 110 120 610 620 630 640 650 660 pF1KE2 VSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGATTQNS 684 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 20:50:24 2016 done: Mon Nov 7 20:50:26 2016 Total Scan time: 8.620 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]