FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2506, 456 aa 1>>>pF1KE2506 456 - 456 aa - 456 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9351+/-0.000873; mu= 14.5355+/- 0.052 mean_var=74.6951+/-14.586, 0's: 0 Z-trim(106.3): 31 B-trim: 5 in 1/51 Lambda= 0.148398 statistics sampled from 8873 (8884) to 8873 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.641), E-opt: 0.2 (0.273), width: 16 Scan time: 2.880 The best scores are: opt bits E(32554) CCDS34057.1 EXOSC9 gene_id:5393|Hs108|chr4 ( 456) 2991 649.8 1.6e-186 CCDS3722.2 EXOSC9 gene_id:5393|Hs108|chr4 ( 439) 2540 553.3 1.8e-157 CCDS31958.1 EXOSC8 gene_id:11340|Hs108|chr13 ( 276) 412 97.6 1.7e-20 CCDS2725.1 EXOSC7 gene_id:23016|Hs108|chr3 ( 291) 371 88.8 7.8e-18 >>CCDS34057.1 EXOSC9 gene_id:5393|Hs108|chr4 (456 aa) initn: 2991 init1: 2991 opt: 2991 Z-score: 3462.0 bits: 649.8 E(32554): 1.6e-186 Smith-Waterman score: 2991; 100.0% identity (100.0% similar) in 456 aa overlap (1-456:1-456) 10 20 30 40 50 60 pF1KE2 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCIDTES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 CELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCIDTES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVTLYTPEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 LCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVTLYTPEER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 DPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 MLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRITAFKMEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 MLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRITAFKMEK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 APIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDSEKEDDEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 APIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDSEKEDDEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 GGDQAIILDGIKMDTGVEVSDIGSQELGFHHVGQTGLEFLTSDAPIILSDSEEEEMIILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GGDQAIILDGIKMDTGVEVSDIGSQELGFHHVGQTGLEFLTSDAPIILSDSEEEEMIILE 370 380 390 400 410 420 430 440 450 pF1KE2 PDKNPKKIRTQTTSAKQEKAPSKKPVKRRKKKRAAN :::::::::::::::::::::::::::::::::::: CCDS34 PDKNPKKIRTQTTSAKQEKAPSKKPVKRRKKKRAAN 430 440 450 >>CCDS3722.2 EXOSC9 gene_id:5393|Hs108|chr4 (439 aa) initn: 2540 init1: 2540 opt: 2540 Z-score: 2940.4 bits: 553.3 E(32554): 1.8e-157 Smith-Waterman score: 2833; 96.3% identity (96.3% similar) in 456 aa overlap (1-456:1-439) 10 20 30 40 50 60 pF1KE2 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS37 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCIDTES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS37 CELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCIDTES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVTLYTPEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS37 LCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVTLYTPEER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS37 DPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 MLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRITAFKMEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS37 MLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRITAFKMEK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 APIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDSEKEDDEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS37 APIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDSEKEDDEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 GGDQAIILDGIKMDTGVEVSDIGSQELGFHHVGQTGLEFLTSDAPIILSDSEEEEMIILE ::::::::::::::::::::::::: :::::::::::::::::: CCDS37 GGDQAIILDGIKMDTGVEVSDIGSQ-----------------DAPIILSDSEEEEMIILE 370 380 390 400 430 440 450 pF1KE2 PDKNPKKIRTQTTSAKQEKAPSKKPVKRRKKKRAAN :::::::::::::::::::::::::::::::::::: CCDS37 PDKNPKKIRTQTTSAKQEKAPSKKPVKRRKKKRAAN 410 420 430 >>CCDS31958.1 EXOSC8 gene_id:11340|Hs108|chr13 (276 aa) initn: 227 init1: 142 opt: 412 Z-score: 481.4 bits: 97.6 E(32554): 1.7e-20 Smith-Waterman score: 412; 29.2% identity (64.0% similar) in 264 aa overlap (11-271:15-272) 10 20 30 40 50 pF1KE2 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFG---TDYGCCIVELGKT :::: .:. : :::. ..:. ...: : : .:.::.: CCDS31 MAAGFKTVEPLEYYRRFL----KENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNT 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 RVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNS :. :. :...:. . .: . :..: . . :. : .. .... ..:: CCDS31 TVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 KCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVT . :. :.::. :. :: . :: :..::::.:: ..: ..:: . . :.:... .:.. CCDS31 QIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTIN-EETA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 LYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICT : . . :.:. :. .::: :.. : :.:::. .::.. : :.:.:... ..: CCDS31 LAEVNLKKKSYLNIRTHPVATSFAVFDD-TLLIVDPTGEEEHLATGTLTIVMDEEGKLCC 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 IQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRI ... :: : .. : . : .. :. .:. ..... CCDS31 LHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK 240 250 260 270 300 310 320 330 340 350 pF1KE2 TAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDS >>CCDS2725.1 EXOSC7 gene_id:23016|Hs108|chr3 (291 aa) initn: 355 init1: 262 opt: 371 Z-score: 433.6 bits: 88.8 E(32554): 7.8e-18 Smith-Waterman score: 371; 27.3% identity (60.8% similar) in 293 aa overlap (1-284:1-289) 10 20 30 40 50 pF1KE2 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRIS---FGTDYGCCIVELGKTRVLG : . ::. :. .......: :.::: ::: ... .. : :.::.: .: CCDS27 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 QVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCID :. :. .:::.. .:: : : .. : :.: :: .:: ... . : . :.. .: CCDS27 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 TESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDE-----V ..::. :. : . ::. ::. ::..:: :::. .:: . : : : : :: . CCDS27 LKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDI 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 TLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREIC : . . : . ::....: :. .. . : .:: . .:: . :....... . CCDS27 EL-SDDPYDCIRLSVENVP-CI-VTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVT 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 TIQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKAL-ENDQKVRKEGGKFGFAESIANQ ... : : ..... . .: .:... . :... ...... . : :: CCDS27 CMRKVGKGSLDPESIFEMME-TGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 RITAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLE 456 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 03:04:42 2016 done: Tue Nov 8 03:04:42 2016 Total Scan time: 2.880 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]