Result of FASTA (omim) for
pF1KE2510
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2510, 1126 aa
1>>>pF1KE2510 1126 - 1126 aa - 1126 aa
Library: /omim/omim.rfq.tfa
64369986 residues in 92320 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.2747+/-0.000458; mu= -18.1719+/- 0.028
mean_var=641.1369+/-135.254, 0's: 0 Z-trim(124.7): 366 B-trim: 1619 in 1/54
Lambda= 0.050652
statistics sampled from 48486 (48950) to 48486 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.796), E-opt: 0.2 (0.53), width: 16
Scan time: 9.410
The best scores are: opt bits E(92320)
NP_443180 (OMIM: 614902) rho GTPase-activating pro (1126) 7921 594.9 1e-168
NP_001353107 (OMIM: 614902) rho GTPase-activating (1287) 4583 351.0 3e-95
XP_016881727 (OMIM: 614902) rho GTPase-activating ( 711) 3919 302.2 7.8e-81
NP_001166101 (OMIM: 614902) rho GTPase-activating (1123) 3601 279.2 1.1e-73
XP_011524723 (OMIM: 614902) rho GTPase-activating ( 703) 3554 275.5 8.3e-73
XP_006723066 (OMIM: 614902) rho GTPase-activating ( 818) 3516 272.8 6.3e-72
XP_011524719 (OMIM: 614902) rho GTPase-activating (1152) 3516 273.0 8.1e-72
XP_011524718 (OMIM: 614902) rho GTPase-activating (1161) 3516 273.0 8.1e-72
XP_011524722 (OMIM: 614902) rho GTPase-activating (1162) 3516 273.0 8.1e-72
XP_006723062 (OMIM: 614902) rho GTPase-activating (1298) 3516 273.0 8.8e-72
XP_011524720 (OMIM: 614902) rho GTPase-activating (1134) 3055 239.3 1.1e-61
XP_016874086 (OMIM: 608541) rho GTPase-activating ( 660) 1301 110.9 2.9e-23
XP_016874085 (OMIM: 608541) rho GTPase-activating (2008) 1301 111.3 6.4e-23
XP_016874084 (OMIM: 608541) rho GTPase-activating (2061) 1301 111.3 6.5e-23
XP_011541374 (OMIM: 608541) rho GTPase-activating (2061) 1301 111.3 6.5e-23
XP_011541375 (OMIM: 608541) rho GTPase-activating (2074) 1301 111.3 6.6e-23
NP_001136157 (OMIM: 608541) rho GTPase-activating (2087) 1301 111.3 6.6e-23
XP_005271793 (OMIM: 608541) rho GTPase-activating (2101) 1301 111.3 6.6e-23
XP_011541377 (OMIM: 608541) rho GTPase-activating (1762) 1283 110.0 1.5e-22
NP_055530 (OMIM: 608541) rho GTPase-activating pro (1738) 1235 106.4 1.6e-21
NP_065805 (OMIM: 100300,610911) rho GTPase-activat (1444) 1059 93.5 1.1e-17
XP_006713777 (OMIM: 100300,610911) rho GTPase-acti (1424) 1057 93.4 1.2e-17
XP_016856449 (OMIM: 614264) rho GTPase-activating ( 967) 1038 91.8 2.3e-17
NP_859071 (OMIM: 614264) rho GTPase-activating pro ( 890) 1031 91.3 3.1e-17
XP_005245127 (OMIM: 614264) rho GTPase-activating (1044) 1031 91.3 3.5e-17
NP_001020769 (OMIM: 614264) rho GTPase-activating (1101) 1031 91.4 3.6e-17
NP_954976 (OMIM: 610591) rho GTPase-activating pro ( 548) 486 51.2 2.1e-05
XP_011522776 (OMIM: 610591) rho GTPase-activating ( 581) 486 51.3 2.2e-05
XP_005257185 (OMIM: 610591) rho GTPase-activating ( 667) 486 51.3 2.5e-05
XP_016879801 (OMIM: 610591) rho GTPase-activating ( 689) 486 51.3 2.5e-05
XP_011522774 (OMIM: 610591) rho GTPase-activating ( 722) 486 51.4 2.6e-05
XP_011522773 (OMIM: 610591) rho GTPase-activating ( 865) 486 51.4 3e-05
XP_006721810 (OMIM: 610591) rho GTPase-activating ( 867) 486 51.4 3e-05
XP_006721808 (OMIM: 610591) rho GTPase-activating ( 889) 486 51.4 3e-05
NP_001269219 (OMIM: 610591) rho GTPase-activating ( 889) 486 51.4 3e-05
XP_011522771 (OMIM: 610591) rho GTPase-activating ( 900) 486 51.4 3.1e-05
XP_011522770 (OMIM: 610591) rho GTPase-activating ( 922) 486 51.5 3.1e-05
XP_016879800 (OMIM: 610591) rho GTPase-activating ( 922) 486 51.5 3.1e-05
NP_060524 (OMIM: 608293) rho GTPase-activating pro ( 803) 464 49.8 8.6e-05
NP_001006635 (OMIM: 608293) rho GTPase-activating ( 881) 464 49.8 9.2e-05
XP_024306104 (OMIM: 608293) rho GTPase-activating ( 804) 461 49.6 0.0001
XP_011544177 (OMIM: 608293) rho GTPase-activating ( 885) 462 49.7 0.0001
NP_001193531 (OMIM: 118423,604356) N-chimaerin iso ( 334) 446 48.1 0.00011
NP_001020372 (OMIM: 118423,604356) N-chimaerin iso ( 433) 446 48.2 0.00014
XP_024308769 (OMIM: 610578) rho GTPase-activating ( 241) 437 47.3 0.00014
XP_024308768 (OMIM: 610578) rho GTPase-activating ( 241) 437 47.3 0.00014
XP_016878879 (OMIM: 608293) rho GTPase-activating ( 794) 454 49.1 0.00014
NP_001813 (OMIM: 118423,604356) N-chimaerin isofor ( 459) 446 48.3 0.00014
NP_001358442 (OMIM: 118423,604356) N-chimaerin iso ( 459) 446 48.3 0.00014
NP_001358443 (OMIM: 118423,604356) N-chimaerin iso ( 476) 446 48.3 0.00015
>>NP_443180 (OMIM: 614902) rho GTPase-activating protein (1126 aa)
initn: 7921 init1: 7921 opt: 7921 Z-score: 3150.8 bits: 594.9 E(92320): 1e-168
Smith-Waterman score: 7921; 100.0% identity (100.0% similar) in 1126 aa overlap (1-1126:1-1126)
10 20 30 40 50 60
pF1KE2 MVARSTDSLDGPGEGSVQPLPTAGGPSVKGKPGKRLSAPRGPFPRLADCAHFHYENVDFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 MVARSTDSLDGPGEGSVQPLPTAGGPSVKGKPGKRLSAPRGPFPRLADCAHFHYENVDFG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 HIQLLLSPDREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 HIQLLLSPDREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 CLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDNHGRRLLLSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 CLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDNHGRRLLLSEE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFFPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 ASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFFPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 ECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRPRGKLAGLLRTFMRSRPSRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 ECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRPRGKLAGLLRTFMRSRPSRQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGVSSNIQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 RLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGVSSNIQR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 RLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 VGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSCPST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 VGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSCPST
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 RLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFALGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 RLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFALGRG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 PSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAELLGAGGAPASAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 PSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAELLGAGGAPASAT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 PTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 PTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 LLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 EPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 EPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 QLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 QLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 PSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 PSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGM
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 ASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 ASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120
pF1KE2 YGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
::::::::::::::::::::::::::::::::::::::::::::::
NP_443 YGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
1090 1100 1110 1120
>>NP_001353107 (OMIM: 614902) rho GTPase-activating prot (1287 aa)
initn: 4591 init1: 4423 opt: 4583 Z-score: 1831.7 bits: 351.0 E(92320): 3e-95
Smith-Waterman score: 6614; 86.1% identity (86.1% similar) in 1158 aa overlap (1-997:1-1158)
10 20 30 40 50 60
pF1KE2 MVARSTDSLDGPGEGSVQPLPTAGGPSVKGKPGKRLSAPRGPFPRLADCAHFHYENVDFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVARSTDSLDGPGEGSVQPLPTAGGPSVKGKPGKRLSAPRGPFPRLADCAHFHYENVDFG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 HIQLLLSPDREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HIQLLLSPDREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 CLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDNHGRRLLLSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDNHGRRLLLSEE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFFPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFFPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 ECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRPRGKLAGLLRTFMRSRPSRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRPRGKLAGLLRTFMRSRPSRQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 RLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGVSSNIQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGVSSNIQR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 VGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSCPST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSCPST
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 RLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFALGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFALGRG
550 560 570 580 590 600
610 620 630 640
pF1KE2 PSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGA-------------
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAGLQRLHRLRRPHS
610 620 630 640 650 660
pF1KE2 ------------------------------------------------------------
NP_001 SSDAFPVGPAPAGSCESLSSSSSSESSSSESSSSSSESSAAGLGALSGSPSHRTSAWLDD
670 680 690 700 710 720
pF1KE2 ------------------------------------------------------------
NP_001 GDELDFSPPRCLEGLRGLDFDPLTFRCSSPTPGDPAPPASPAPPAPASAFPPRVTPQAIS
730 740 750 760 770 780
650 660 670
pF1KE2 ----------------------------ELLGAGGAPASATPTPALSPGRSLRPHLIPLL
::::::::::::::::::::::::::::::::
NP_001 PRGPTSPASPAALDISEPLAVSVPPAVLELLGAGGAPASATPTPALSPGRSLRPHLIPLL
790 800 810 820 830 840
680 690 700 710 720 730
pF1KE2 LRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLSLLRPGGAPPPPPKNPARLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLSLLRPGGAPPPPPKNPARLM
850 860 870 880 890 900
740 750 760 770 780 790
pF1KE2 ALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGGEPLGTSGSGPPPNSLAHPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGGEPLGTSGSGPPPNSLAHPG
910 920 930 940 950 960
800 810 820 830 840 850
pF1KE2 AWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSAQLRAGGGGRDAPEAAAQSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSAQLRAGGGGRDAPEAAAQSP
970 980 990 1000 1010 1020
860 870 880 890 900 910
pF1KE2 CSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQPSSPAPVWRSSLGPPAPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQPSSPAPVWRSSLGPPAPLD
1030 1040 1050 1060 1070 1080
920 930 940 950 960 970
pF1KE2 RGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGMLGQSPPLHRSPDFLLSYPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGMLGQSPPLHRSPDFLLSYPP
1090 1100 1110 1120 1130 1140
980 990 1000 1010 1020 1030
pF1KE2 APSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSPASSSSSSPPAHPRSRSDPG
::::::::::::::::::
NP_001 APSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSPASSSSSSPPAHPRSRSDPG
1150 1160 1170 1180 1190 1200
>--
initn: 975 init1: 975 opt: 975 Z-score: 406.8 bits: 87.3 E(92320): 6.9e-16
Smith-Waterman score: 975; 100.0% identity (100.0% similar) in 129 aa overlap (998-1126:1159-1287)
970 980 990 1000 1010 1020
pF1KE2 HRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSPASSSSSS
::::::::::::::::::::::::::::::
NP_001 HRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSPASSSSSS
1130 1140 1150 1160 1170 1180
1030 1040 1050 1060 1070 1080
pF1KE2 PPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPAYGRGGEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPAYGRGGEL
1190 1200 1210 1220 1230 1240
1090 1100 1110 1120
pF1KE2 HRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
:::::::::::::::::::::::::::::::::::::::
NP_001 HRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
1250 1260 1270 1280
>>XP_016881727 (OMIM: 614902) rho GTPase-activating prot (711 aa)
initn: 2643 init1: 2144 opt: 3919 Z-score: 1572.9 bits: 302.2 E(92320): 7.8e-81
Smith-Waterman score: 4371; 98.0% identity (98.2% similar) in 659 aa overlap (3-650:40-698)
10 20 30
pF1KE2 MVARSTDSLDGPGEGSVQPLPTAGGPSVKGKP
::::::::::::::::::::::::::::::
XP_016 GALDPRCQITMLSLSLCSHLWGPLILSALQARSTDSLDGPGEGSVQPLPTAGGPSVKGKP
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 GKRLSAPRGPFPRLADCAHFHYENVDFGHIQLLLSPDREGPSLSGENELVFGVQVTCQGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKRLSAPRGPFPRLADCAHFHYENVDFGHIQLLLSPDREGPSLSGENELVFGVQVTCQGR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 SWPVLRSYDDFRSLDAHLHRCIFDRRFSCLPELPPPPEGARAAQMLVPLLLQYLETLSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWPVLRSYDDFRSLDAHLHRCIFDRRFSCLPELPPPPEGARAAQMLVPLLLQYLETLSGL
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 VDSNLNCGPVLTWMELDNHGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDSNLNCGPVLTWMELDNHGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDI
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 VSVIDMPPTEDRSWWRGKRGFQVGFFPSECVELFTERPGPGLKA-DADGPPCGIPAPQGI
:::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::
XP_016 VSVIDMPPTEDRSWWRGKRGFQVGFFPSECVELFTERPGPGLKAADADGPPCGIPAPQGI
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE2 SSLTSAVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSLTSAVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQV
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE2 LRCCSEFIEAHGVVDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRCCSEFIEAHGVVDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKL
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE2 YFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMA
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE2 RHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFS
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE2 DTFTSAGLDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTFTSAGLDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASP
550 560 570 580 590 600
580 590 600 610 620
pF1KE2 AERR----------KGERGEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQP
:::: ::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AERRPPVSPPNRRRKGERGEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQP
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE2 SGSRPDTVTLRSAKSEESLSSQASGAELLGAGGAPASATPTPALSPGRSLRPHLIPLLLR
:::::::::::::::::::::::::: :.
XP_016 SGSRPDTVTLRSAKSEESLSSQASGAGLIIHRCVCKDHTAQF
670 680 690 700 710
>>NP_001166101 (OMIM: 614902) rho GTPase-activating prot (1123 aa)
initn: 5537 init1: 3450 opt: 3601 Z-score: 1444.7 bits: 279.2 E(92320): 1.1e-73
Smith-Waterman score: 5579; 82.0% identity (82.0% similar) in 1050 aa overlap (137-1025:1-1022)
110 120 130 140 150 160
pF1KE2 DAHLHRCIFDRRFSCLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWM
::::::::::::::::::::::::::::::
NP_001 MLVPLLLQYLETLSGLVDSNLNCGPVLTWM
10 20 30
170 180 190 200 210 220
pF1KE2 ELDNHGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELDNHGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSW
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE2 WRGKRGFQVGFFPSECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRPRGKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WRGKRGFQVGFFPSECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRPRGKLA
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE2 GLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVD
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE2 GIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLY
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE2 GKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAI
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE2 VWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCL
340 350 360 370 380 390
530 540 550 560 570 580
pF1KE2 LPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKP
400 410 420 430 440 450
590 600 610 620 630 640
pF1KE2 GGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASG
460 470 480 490 500 510
pF1KE2 A-----------------------------------------------------------
:
NP_001 AGLQRLHRLRRPHSSSDAFPVGPAPAGSCESLSSSSSSESSSSESSSSSSESSAAGLGAL
520 530 540 550 560 570
pF1KE2 ------------------------------------------------------------
NP_001 SGSPSHRTSAWLDDGDELDFSPPRCLEGLRGLDFDPLTFRCSSPTPGDPAPPASPAPPAP
580 590 600 610 620 630
650 660
pF1KE2 ------------------------------------------ELLGAGGAPASATPTPAL
::::::::::::::::::
NP_001 ASAFPPRVTPQAISPRGPTSPASPAALDISEPLAVSVPPAVLELLGAGGAPASATPTPAL
640 650 660 670 680 690
670 680 690 700 710 720
pF1KE2 SPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLSLLRPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLSLLRPG
700 710 720 730 740 750
730 740 750 760 770 780
pF1KE2 GAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGGEPLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGGEPLGT
760 770 780 790 800 810
790 800 810 820 830 840
pF1KE2 SGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSAQLRAG
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQV-------
820 830 840 850 860
850 860 870 880 890 900
pF1KE2 GGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQPSSPA
:::::::::::::::::::::::::::::::::::::::
NP_001 ---------------------PTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQPSSPA
870 880 890 900
910 920 930 940 950 960
pF1KE2 PVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGMLGQSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGMLGQSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 PLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSPASSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSPASSSS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 SSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPAYGRGG
NP_001 SSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPAYGRGG
1030 1040 1050 1060 1070 1080
>--
initn: 782 init1: 782 opt: 782 Z-score: 331.4 bits: 73.2 E(92320): 1.1e-11
Smith-Waterman score: 782; 100.0% identity (100.0% similar) in 101 aa overlap (1026-1126:1023-1123)
1000 1010 1020 1030 1040 1050
pF1KE2 HPARRPTPPEPLYVNLALGPRGPSPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGP
::::::::::::::::::::::::::::::
NP_001 HPARRPTPPEPLYVNLALGPRGPSPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGP
1000 1010 1020 1030 1040 1050
1060 1070 1080 1090 1100 1110
pF1KE2 RTPHRVPGPWGPPEPLLLYRAAPPAYGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTPHRVPGPWGPPEPLLLYRAAPPAYGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWS
1060 1070 1080 1090 1100 1110
1120
pF1KE2 LHSEGQTRSYC
:::::::::::
NP_001 LHSEGQTRSYC
1120
>>XP_011524723 (OMIM: 614902) rho GTPase-activating prot (703 aa)
initn: 1893 init1: 1787 opt: 3554 Z-score: 1428.8 bits: 275.5 E(92320): 8.3e-73
Smith-Waterman score: 3555; 81.8% identity (84.9% similar) in 680 aa overlap (3-677:40-675)
10 20 30
pF1KE2 MVARSTDSLDGPGEGSVQPLPTAGGPSVKGKP
::::::::::::::::::::::::::::::
XP_011 GALDPRCQITMLSLSLCSHLWGPLILSALQARSTDSLDGPGEGSVQPLPTAGGPSVKGKP
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 GKRLSAPRGPFPRLADCAHFHYENVDFGHIQLLLSPDREGPSLSGENELVFGVQVTCQGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKRLSAPRGPFPRLADCAHFHYENVDFGHIQLLLSPDREGPSLSGENELVFGVQVTCQGR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 SWPVLRSYDDFRSLDAHLHRCIFDRRFSCLPELPPPPEGARAAQMLVPLLLQYLETLSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SWPVLRSYDDFRSLDAHLHRCIFDRRFSCLPELPPPPEGARAAQMLVPLLLQYLETLSGL
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 VDSNLNCGPVLTWMELDNHGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDSNLNCGPVLTWMELDNHGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDI
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 VSVIDMPPTEDRSWWRGKRGFQVGFFPSECVELFTERPGPGLKA-DADGPPCGIPAPQGI
:::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::
XP_011 VSVIDMPPTEDRSWWRGKRGFQVGFFPSECVELFTERPGPGLKAADADGPPCGIPAPQGI
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE2 SSLTSAVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSLTSAVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQV
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE2 LRCCSEFIEAHGVVDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRCCSEFIEAHGVVDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKL
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE2 YFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMA
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE2 RHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFS
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE2 DTFTSAGLDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASP
:::::::::::. : : . : :. : . . :::: :
XP_011 DTFTSAGLDPAA----P-PLRIPTSWPGRR---SSFTPCSSWGRLG-------------P
550 560 570 580
580 590 600 610 620 630
pF1KE2 AERRKGERGEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAP-PQPSGSRPDTVT
: . . ::.:.. .: : . : :::: . .
XP_011 -------------------WVHLGGGGRSPDLTPPRPHP--DSPPCPGPQPSQDSARRRA
590 600 610 620
640 650 660 670 680
pF1KE2 LRSAKSEESLSSQASGAELLGAGGAPASATPT---PALSPGRSLRPHLIPLLLRGAEAPL
: .: .. :. :: .: :: :: : : .:: .:
XP_011 LWPEVTEARAAALAGCRELPPHQLVPPRPPPTCLLPACS--RLIRPGPLPCQPGWACCGA
630 640 650 660 670 680
690 700 710 720 730 740
pF1KE2 TDACQQEMCSKLRGAQGPLGPDMESPLPPPPLSLLRPGGAPPPPPKNPARLMALALAERA
XP_011 GAWAVALGFACGLGRPQS
690 700
>>XP_006723066 (OMIM: 614902) rho GTPase-activating prot (818 aa)
initn: 3857 init1: 3500 opt: 3516 Z-score: 1412.9 bits: 272.8 E(92320): 6.3e-72
Smith-Waterman score: 3996; 77.5% identity (77.5% similar) in 783 aa overlap (515-1126:36-818)
490 500 510 520 530 540
pF1KE2 GAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSCPSTRLLT
:: : ::::::::::::::::::::::
XP_006 RRWEVPRLDPAPAPPRLPALPRTPAQSGLSTSEGPLARGRCLLPRPKSLAGSCPSTRLLT
10 20 30 40 50 60
550 560 570 580 590
pF1KE2 LEEAQARTQGRLGTPTEPTTPKAPASPAERR----------KGERGEKQRKPGGSSWKTF
::::::::::::::::::::::::::::::: :::::::::::::::::::
XP_006 LEEAQARTQGRLGTPTEPTTPKAPASPAERRPPVSPPNRRRKGERGEKQRKPGGSSWKTF
70 80 90 100 110 120
600 610 620 630 640
pF1KE2 FALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGA-------
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAGLQRLHR
130 140 150 160 170 180
pF1KE2 ------------------------------------------------------------
XP_006 LRRPHSSSDAFPVGPAPAGSCESLSSSSSSESSSSESSSSSSESSAAGLGALSGSPSHRT
190 200 210 220 230 240
pF1KE2 ------------------------------------------------------------
XP_006 SAWLDDGDELDFSPPRCLEGLRGLDFDPLTFRCSSPTPGDPAPPASPAPPAPASAFPPRV
250 260 270 280 290 300
650 660 670
pF1KE2 ----------------------------------ELLGAGGAPASATPTPALSPGRSLRP
::::::::::::::::::::::::::
XP_006 TPQAISPRGPTSPASPAALDISEPLAVSVPPAVLELLGAGGAPASATPTPALSPGRSLRP
310 320 330 340 350 360
680 690 700 710 720 730
pF1KE2 HLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLSLLRPGGAPPPPPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLSLLRPGGAPPPPPK
370 380 390 400 410 420
740 750 760 770 780 790
pF1KE2 NPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGGEPLGTSGSGPPPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGGEPLGTSGSGPPPN
430 440 450 460 470 480
800 810 820 830 840 850
pF1KE2 SLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSAQLRAGGGGRDAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSAQLRAGGGGRDAPE
490 500 510 520 530 540
860 870 880 890 900 910
pF1KE2 AAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQPSSPAPVWRSSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQPSSPAPVWRSSLG
550 560 570 580 590 600
920 930 940 950 960 970
pF1KE2 PPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGMLGQSPPLHRSPDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGMLGQSPPLHRSPDF
610 620 630 640 650 660
980 990 1000 1010 1020 1030
pF1KE2 LLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSPASSSSSSPPAHPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSPASSSSSSPPAHPR
670 680 690 700 710 720
1040 1050 1060 1070 1080 1090
pF1KE2 SRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPAYGRGGELHRGSLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPAYGRGGELHRGSLY
730 740 750 760 770 780
1100 1110 1120
pF1KE2 RNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
:::::::::::::::::::::::::::::::::
XP_006 RNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
790 800 810
>>XP_011524719 (OMIM: 614902) rho GTPase-activating prot (1152 aa)
initn: 4301 init1: 3500 opt: 3516 Z-score: 1411.0 bits: 273.0 E(92320): 8.1e-72
Smith-Waterman score: 6604; 85.9% identity (85.9% similar) in 1152 aa overlap (137-1126:1-1152)
110 120 130 140 150 160
pF1KE2 DAHLHRCIFDRRFSCLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWM
::::::::::::::::::::::::::::::
XP_011 MLVPLLLQYLETLSGLVDSNLNCGPVLTWM
10 20 30
170 180 190 200 210 220
pF1KE2 ELDNHGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELDNHGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSW
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE2 WRGKRGFQVGFFPSECVELFTERPGPGLKA-DADGPPCGIPAPQGISSLTSAVPRPRGKL
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_011 WRGKRGFQVGFFPSECVELFTERPGPGLKAADADGPPCGIPAPQGISSLTSAVPRPRGKL
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE2 AGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVV
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE2 DGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQL
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE2 YGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLA
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE2 IVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRC
340 350 360 370 380 390
530 540 550 560 570 580
pF1KE2 LLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRK
400 410 420 430 440 450
590 600 610 620 630 640
pF1KE2 PGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQAS
460 470 480 490 500 510
pF1KE2 GA----------------------------------------------------------
::
XP_011 GAGLQRLHRLRRPHSSSDAFPVGPAPAGSCESLSSSSSSESSSSESSSSSSESSAAGLGA
520 530 540 550 560 570
pF1KE2 ------------------------------------------------------------
XP_011 LSGSPSHRTSAWLDDGDELDFSPPRCLEGLRGLDFDPLTFRCSSPTPGDPAPPASPAPPA
580 590 600 610 620 630
650 660
pF1KE2 -------------------------------------------ELLGAGGAPASATPTPA
:::::::::::::::::
XP_011 PASAFPPRVTPQAISPRGPTSPASPAALDISEPLAVSVPPAVLELLGAGGAPASATPTPA
640 650 660 670 680 690
670 680 690 700 710 720
pF1KE2 LSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLSLLRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLSLLRP
700 710 720 730 740 750
730 740 750 760 770 780
pF1KE2 GGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGGEPLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGGEPLG
760 770 780 790 800 810
790 800 810 820 830 840
pF1KE2 TSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSAQLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSAQLRA
820 830 840 850 860 870
850 860 870 880 890 900
pF1KE2 GGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQPSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQPSSP
880 890 900 910 920 930
910 920 930 940 950 960
pF1KE2 APVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGMLGQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGMLGQS
940 950 960 970 980 990
970 980 990 1000 1010 1020
pF1KE2 PPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSPASSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSPASSS
1000 1010 1020 1030 1040 1050
1030 1040 1050 1060 1070 1080
pF1KE2 SSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPAYGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPAYGRG
1060 1070 1080 1090 1100 1110
1090 1100 1110 1120
pF1KE2 GELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
::::::::::::::::::::::::::::::::::::::::::
XP_011 GELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
1120 1130 1140 1150
>>XP_011524718 (OMIM: 614902) rho GTPase-activating prot (1161 aa)
initn: 6447 init1: 3500 opt: 3516 Z-score: 1410.9 bits: 273.0 E(92320): 8.1e-72
Smith-Waterman score: 6569; 85.2% identity (85.2% similar) in 1158 aa overlap (140-1126:4-1161)
110 120 130 140 150 160
pF1KE2 LHRCIFDRRFSCLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELD
::::::::::::::::::::::::::::::
XP_011 MLVPLLLQYLETLSGLVDSNLNCGPVLTWMELD
10 20 30
170 180 190 200 210 220
pF1KE2 NHGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRG
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE2 KRGFQVGFFPSECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRPRGKLAGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRGFQVGFFPSECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRPRGKLAGLL
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE2 RTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIY
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE2 RLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKF
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE2 SEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWA
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE2 PNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPR
340 350 360 370 380 390
530 540 550 560 570
pF1KE2 PKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERR----------KGER
:::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 PKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRPPVSPPNRRRKGER
400 410 420 430 440 450
580 590 600 610 620 630
pF1KE2 GEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEES
460 470 480 490 500 510
640
pF1KE2 LSSQASGA----------------------------------------------------
::::::::
XP_011 LSSQASGAGLQRLHRLRRPHSSSDAFPVGPAPAGSCESLSSSSSSESSSSESSSSSSESS
520 530 540 550 560 570
pF1KE2 ------------------------------------------------------------
XP_011 AAGLGALSGSPSHRTSAWLDDGDELDFSPPRCLEGLRGLDFDPLTFRCSSPTPGDPAPPA
580 590 600 610 620 630
650
pF1KE2 -------------------------------------------------ELLGAGGAPAS
:::::::::::
XP_011 SPAPPAPASAFPPRVTPQAISPRGPTSPASPAALDISEPLAVSVPPAVLELLGAGGAPAS
640 650 660 670 680 690
660 670 680 690 700 710
pF1KE2 ATPTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATPTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPP
700 710 720 730 740 750
720 730 740 750 760 770
pF1KE2 LSLLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSLLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEV
760 770 780 790 800 810
780 790 800 810 820 830
pF1KE2 GGEPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGEPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQV
820 830 840 850 860 870
840 850 860 870 880 890
pF1KE2 SAQLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAQLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPS
880 890 900 910 920 930
900 910 920 930 940 950
pF1KE2 FQPSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQPSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASY
940 950 960 970 980 990
960 970 980 990 1000 1010
pF1KE2 GMLGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GMLGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGP
1000 1010 1020 1030 1040 1050
1020 1030 1040 1050 1060 1070
pF1KE2 SPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAP
1060 1070 1080 1090 1100 1110
1080 1090 1100 1110 1120
pF1KE2 PAYGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAYGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
1120 1130 1140 1150 1160
>>XP_011524722 (OMIM: 614902) rho GTPase-activating prot (1162 aa)
initn: 5638 init1: 3500 opt: 3516 Z-score: 1410.9 bits: 273.0 E(92320): 8.1e-72
Smith-Waterman score: 6547; 85.1% identity (85.1% similar) in 1158 aa overlap (141-1126:5-1162)
120 130 140 150 160 170
pF1KE2 HRCIFDRRFSCLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDN
::::::::::::::::::::::::::::::
XP_011 MLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDN
10 20 30
180 190 200 210 220 230
pF1KE2 HGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGK
40 50 60 70 80 90
240 250 260 270 280
pF1KE2 RGFQVGFFPSECVELFTERPGPGLKA-DADGPPCGIPAPQGISSLTSAVPRPRGKLAGLL
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_011 RGFQVGFFPSECVELFTERPGPGLKAADADGPPCGIPAPQGISSLTSAVPRPRGKLAGLL
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE2 RTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIY
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE2 RLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKF
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE2 SEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWA
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE2 PNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPR
340 350 360 370 380 390
530 540 550 560 570
pF1KE2 PKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERR----------KGER
:::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 PKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRPPVSPPNRRRKGER
400 410 420 430 440 450
580 590 600 610 620 630
pF1KE2 GEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEES
460 470 480 490 500 510
640
pF1KE2 LSSQASGA----------------------------------------------------
::::::::
XP_011 LSSQASGAGLQRLHRLRRPHSSSDAFPVGPAPAGSCESLSSSSSSESSSSESSSSSSESS
520 530 540 550 560 570
pF1KE2 ------------------------------------------------------------
XP_011 AAGLGALSGSPSHRTSAWLDDGDELDFSPPRCLEGLRGLDFDPLTFRCSSPTPGDPAPPA
580 590 600 610 620 630
650
pF1KE2 -------------------------------------------------ELLGAGGAPAS
:::::::::::
XP_011 SPAPPAPASAFPPRVTPQAISPRGPTSPASPAALDISEPLAVSVPPAVLELLGAGGAPAS
640 650 660 670 680 690
660 670 680 690 700 710
pF1KE2 ATPTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATPTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPP
700 710 720 730 740 750
720 730 740 750 760 770
pF1KE2 LSLLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSLLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEV
760 770 780 790 800 810
780 790 800 810 820 830
pF1KE2 GGEPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGEPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQV
820 830 840 850 860 870
840 850 860 870 880 890
pF1KE2 SAQLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAQLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPS
880 890 900 910 920 930
900 910 920 930 940 950
pF1KE2 FQPSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQPSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASY
940 950 960 970 980 990
960 970 980 990 1000 1010
pF1KE2 GMLGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GMLGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGP
1000 1010 1020 1030 1040 1050
1020 1030 1040 1050 1060 1070
pF1KE2 SPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAP
1060 1070 1080 1090 1100 1110
1080 1090 1100 1110 1120
pF1KE2 PAYGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAYGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
1120 1130 1140 1150 1160
>>XP_006723062 (OMIM: 614902) rho GTPase-activating prot (1298 aa)
initn: 5638 init1: 3500 opt: 3516 Z-score: 1410.3 bits: 273.0 E(92320): 8.8e-72
Smith-Waterman score: 6547; 85.1% identity (85.1% similar) in 1158 aa overlap (141-1126:141-1298)
120 130 140 150 160 170
pF1KE2 HRCIFDRRFSCLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDN
::::::::::::::::::::::::::::::
XP_006 HRCIFDRRFSCLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDN
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 HGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGK
180 190 200 210 220 230
240 250 260 270 280
pF1KE2 RGFQVGFFPSECVELFTERPGPGLKA-DADGPPCGIPAPQGISSLTSAVPRPRGKLAGLL
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_006 RGFQVGFFPSECVELFTERPGPGLKAADADGPPCGIPAPQGISSLTSAVPRPRGKLAGLL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE2 RTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIY
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE2 RLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKF
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE2 SEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWA
420 430 440 450 460 470
470 480 490 500 510 520
pF1KE2 PNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPR
480 490 500 510 520 530
530 540 550 560 570
pF1KE2 PKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERR----------KGER
:::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_006 PKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRPPVSPPNRRRKGER
540 550 560 570 580 590
580 590 600 610 620 630
pF1KE2 GEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEES
600 610 620 630 640 650
640
pF1KE2 LSSQASGA----------------------------------------------------
::::::::
XP_006 LSSQASGAGLQRLHRLRRPHSSSDAFPVGPAPAGSCESLSSSSSSESSSSESSSSSSESS
660 670 680 690 700 710
pF1KE2 ------------------------------------------------------------
XP_006 AAGLGALSGSPSHRTSAWLDDGDELDFSPPRCLEGLRGLDFDPLTFRCSSPTPGDPAPPA
720 730 740 750 760 770
650
pF1KE2 -------------------------------------------------ELLGAGGAPAS
:::::::::::
XP_006 SPAPPAPASAFPPRVTPQAISPRGPTSPASPAALDISEPLAVSVPPAVLELLGAGGAPAS
780 790 800 810 820 830
660 670 680 690 700 710
pF1KE2 ATPTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ATPTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPP
840 850 860 870 880 890
720 730 740 750 760 770
pF1KE2 LSLLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSLLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEV
900 910 920 930 940 950
780 790 800 810 820 830
pF1KE2 GGEPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GGEPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQV
960 970 980 990 1000 1010
840 850 860 870 880 890
pF1KE2 SAQLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SAQLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPS
1020 1030 1040 1050 1060 1070
900 910 920 930 940 950
pF1KE2 FQPSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FQPSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASY
1080 1090 1100 1110 1120 1130
960 970 980 990 1000 1010
pF1KE2 GMLGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GMLGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGP
1140 1150 1160 1170 1180 1190
1020 1030 1040 1050 1060 1070
pF1KE2 SPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAP
1200 1210 1220 1230 1240 1250
1080 1090 1100 1110 1120
pF1KE2 PAYGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PAYGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
1260 1270 1280 1290
>--
initn: 1000 init1: 1000 opt: 1000 Z-score: 416.6 bits: 89.2 E(92320): 2e-16
Smith-Waterman score: 1000; 100.0% identity (100.0% similar) in 140 aa overlap (1-140:1-140)
10 20 30 40 50 60
pF1KE2 MVARSTDSLDGPGEGSVQPLPTAGGPSVKGKPGKRLSAPRGPFPRLADCAHFHYENVDFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MVARSTDSLDGPGEGSVQPLPTAGGPSVKGKPGKRLSAPRGPFPRLADCAHFHYENVDFG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 HIQLLLSPDREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HIQLLLSPDREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 CLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDNHGRRLLLSEE
::::::::::::::::::::
XP_006 CLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDNHGRRLLLSEE
130 140 150 160 170 180
1126 residues in 1 query sequences
64369986 residues in 92320 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Oct 24 21:48:45 2019 done: Thu Oct 24 21:48:46 2019
Total Scan time: 9.410 Total Display time: 0.270
Function used was FASTA [36.3.4 Apr, 2011]