FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2515, 371 aa 1>>>pF1KE2515 371 - 371 aa - 371 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0688+/-0.00116; mu= 17.5117+/- 0.070 mean_var=60.1541+/-12.048, 0's: 0 Z-trim(101.5): 54 B-trim: 0 in 0/49 Lambda= 0.165364 statistics sampled from 6494 (6531) to 6494 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.572), E-opt: 0.2 (0.201), width: 16 Scan time: 1.860 The best scores are: opt bits E(32554) CCDS46145.1 PRMT1 gene_id:3276|Hs108|chr19 ( 371) 2494 603.9 7.3e-173 CCDS42592.1 PRMT1 gene_id:3276|Hs108|chr19 ( 353) 2308 559.5 1.6e-159 CCDS58200.1 PRMT8 gene_id:56341|Hs108|chr12 ( 385) 1968 478.4 4.5e-135 CCDS8521.2 PRMT8 gene_id:56341|Hs108|chr12 ( 394) 1968 478.4 4.6e-135 CCDS44554.1 PRMT3 gene_id:10196|Hs108|chr11 ( 469) 1095 270.2 2.6e-72 CCDS7853.1 PRMT3 gene_id:10196|Hs108|chr11 ( 531) 1095 270.2 2.9e-72 CCDS74425.1 PRMT1 gene_id:3276|Hs108|chr19 ( 285) 1032 255.0 5.8e-68 CCDS12250.1 CARM1 gene_id:10498|Hs108|chr19 ( 608) 641 161.9 1.3e-39 CCDS13737.1 PRMT2 gene_id:3275|Hs108|chr21 ( 433) 618 156.4 4.5e-38 CCDS41360.2 PRMT6 gene_id:55170|Hs108|chr1 ( 375) 557 141.8 9.5e-34 CCDS68230.1 PRMT2 gene_id:3275|Hs108|chr21 ( 289) 513 131.2 1.1e-30 CCDS68231.1 PRMT2 gene_id:3275|Hs108|chr21 ( 301) 347 91.6 9.5e-19 CCDS56219.1 PRMT2 gene_id:3275|Hs108|chr21 ( 284) 345 91.1 1.3e-18 CCDS74806.1 PRMT2 gene_id:3275|Hs108|chr21 ( 228) 340 89.9 2.4e-18 CCDS56220.1 PRMT2 gene_id:3275|Hs108|chr21 ( 331) 340 90.0 3.3e-18 >>CCDS46145.1 PRMT1 gene_id:3276|Hs108|chr19 (371 aa) initn: 2494 init1: 2494 opt: 2494 Z-score: 3216.9 bits: 603.9 E(32554): 7.3e-173 Smith-Waterman score: 2494; 100.0% identity (100.0% similar) in 371 aa overlap (1-371:1-371) 10 20 30 40 50 60 pF1KE2 MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 GIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 SISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 RDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 RDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 DPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 DPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 FSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLC 310 320 330 340 350 360 370 pF1KE2 ELSCSTDYRMR ::::::::::: CCDS46 ELSCSTDYRMR 370 >>CCDS42592.1 PRMT1 gene_id:3276|Hs108|chr19 (353 aa) initn: 2308 init1: 2308 opt: 2308 Z-score: 2977.4 bits: 559.5 E(32554): 1.6e-159 Smith-Waterman score: 2332; 95.1% identity (95.1% similar) in 371 aa overlap (1-371:1-353) 10 20 30 40 50 60 pF1KE2 MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHF :::::::::::: :::::::::::::::::::::::::::::: CCDS42 MAAAEAANCIME------------------VSCGQAESSEKPNAEDMTSKDYYFDSYAHF 10 20 30 40 70 80 90 100 110 120 pF1KE2 GIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 GIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE2 SISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 SISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYA 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE2 RDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 RDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE2 DPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 DPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTG 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE2 FSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 FSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLC 290 300 310 320 330 340 370 pF1KE2 ELSCSTDYRMR ::::::::::: CCDS42 ELSCSTDYRMR 350 >>CCDS58200.1 PRMT8 gene_id:56341|Hs108|chr12 (385 aa) initn: 1953 init1: 1953 opt: 1968 Z-score: 2538.5 bits: 478.4 E(32554): 4.5e-135 Smith-Waterman score: 1968; 80.1% identity (94.0% similar) in 351 aa overlap (22-371:40-385) 10 20 30 40 50 pF1KE2 MAAAEAANCIMENFVATLANGMSLQPPLEEVSC-GQAESSEKPNAEDMTSK .: :: :: :... :. : :.:::. CCDS58 KLKEVSSVNSPPSQPPQPVVPAKPVQCVHHVSTQP-----SCPGRGKMSKLLNPEEMTSR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 DYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAG ::::::::::::::::::::::::::::::.::.:.:::::::::::::::: ::::::: CCDS58 DYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 ARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFY :.::.::::::::::. ::.:::.::...::.:::::::::::::::::::::::::::: CCDS58 AKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 ESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDV :::::::..:::::: : ::.:::::.:::.:::::::::.:::::::::::::.::.:: CCDS58 ESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDV 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 AIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNI :.::::::.:::::.::::::::::::::::.:.:.::: ::::..:::::::::.:::: CCDS58 AMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNI 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE2 EFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFT :::.:::. ::::.:..:::::::::::.::::::. ::::.:::.:.::::: :::::: CCDS58 EFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFT 310 320 330 340 350 360 360 370 pF1KE2 IDLDFKGQLCELSCSTDYRMR .:::::::::: : :.::.:: CCDS58 VDLDFKGQLCETSVSNDYKMR 370 380 >>CCDS8521.2 PRMT8 gene_id:56341|Hs108|chr12 (394 aa) initn: 1953 init1: 1953 opt: 1968 Z-score: 2538.3 bits: 478.4 E(32554): 4.6e-135 Smith-Waterman score: 1968; 80.1% identity (94.0% similar) in 351 aa overlap (22-371:49-394) 10 20 30 40 50 pF1KE2 MAAAEAANCIMENFVATLANGMSLQPPLEEVSC-GQAESSEKPNAEDMTSK .: :: :: :... :. : :.:::. CCDS85 NAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQP-----SCPGRGKMSKLLNPEEMTSR 20 30 40 50 60 70 60 70 80 90 100 110 pF1KE2 DYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAG ::::::::::::::::::::::::::::::.::.:.:::::::::::::::: ::::::: CCDS85 DYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAG 80 90 100 110 120 130 120 130 140 150 160 170 pF1KE2 ARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFY :.::.::::::::::. ::.:::.::...::.:::::::::::::::::::::::::::: CCDS85 AKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFY 140 150 160 170 180 190 180 190 200 210 220 230 pF1KE2 ESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDV :::::::..:::::: : ::.:::::.:::.:::::::::.:::::::::::::.::.:: CCDS85 ESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDV 200 210 220 230 240 250 240 250 260 270 280 290 pF1KE2 AIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNI :.::::::.:::::.::::::::::::::::.:.:.::: ::::..:::::::::.:::: CCDS85 AMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNI 260 270 280 290 300 310 300 310 320 330 340 350 pF1KE2 EFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFT :::.:::. ::::.:..:::::::::::.::::::. ::::.:::.:.::::: :::::: CCDS85 EFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFT 320 330 340 350 360 370 360 370 pF1KE2 IDLDFKGQLCELSCSTDYRMR .:::::::::: : :.::.:: CCDS85 VDLDFKGQLCETSVSNDYKMR 380 390 >>CCDS44554.1 PRMT3 gene_id:10196|Hs108|chr11 (469 aa) initn: 1089 init1: 911 opt: 1095 Z-score: 1411.6 bits: 270.2 E(32554): 2.6e-72 Smith-Waterman score: 1095; 49.4% identity (77.1% similar) in 328 aa overlap (32-358:139-464) 10 20 30 40 50 60 pF1KE2 AAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFG .:... : :: ::.::.:.: CCDS44 SAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQED--EDGVYFSSYGHYG 110 120 130 140 150 160 70 80 90 100 110 120 pF1KE2 IHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSS ::::::::..:: .::. ...: :.:::::::::: ::::: ::::::::.::.:.. : CCDS44 IHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSE 170 180 190 200 210 220 130 140 150 160 170 180 pF1KE2 ISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYAR : :. :.. :::. ..:.::::.:::.:::::::.:::::::: :..::::..::::. CCDS44 ILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAK 230 240 250 260 270 280 190 200 210 220 230 240 pF1KE2 DKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVD .:.:: : ..:: :. ..:. : . . .: .:..:::: :::.: ..: : .:.:.: CCDS44 NKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLD 290 300 310 320 330 340 250 260 270 280 290 300 pF1KE2 PKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTR-CHKRTG :: :... : ::..: .:... :: :.: : :.. :... :...::.: : . ::.:. CCDS44 PKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVV 350 360 370 380 390 400 310 320 330 340 350 360 pF1KE2 FSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLC :::.:.: :::::::: .: ..::.:: . : . .. : :. :.: :. :. . : CCDS44 FSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTY 410 420 430 440 450 460 370 pF1KE2 ELSCSTDYRMR CCDS44 GLQ >>CCDS7853.1 PRMT3 gene_id:10196|Hs108|chr11 (531 aa) initn: 1089 init1: 911 opt: 1095 Z-score: 1410.8 bits: 270.2 E(32554): 2.9e-72 Smith-Waterman score: 1095; 49.4% identity (77.1% similar) in 328 aa overlap (32-358:201-526) 10 20 30 40 50 60 pF1KE2 AAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFG .:... : :: ::.::.:.: CCDS78 SAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQED--EDGVYFSSYGHYG 180 190 200 210 220 70 80 90 100 110 120 pF1KE2 IHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSS ::::::::..:: .::. ...: :.:::::::::: ::::: ::::::::.::.:.. : CCDS78 IHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSE 230 240 250 260 270 280 130 140 150 160 170 180 pF1KE2 ISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYAR : :. :.. :::. ..:.::::.:::.:::::::.:::::::: :..::::..::::. CCDS78 ILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAK 290 300 310 320 330 340 190 200 210 220 230 240 pF1KE2 DKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVD .:.:: : ..:: :. ..:. : . . .: .:..:::: :::.: ..: : .:.:.: CCDS78 NKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLD 350 360 370 380 390 400 250 260 270 280 290 300 pF1KE2 PKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTR-CHKRTG :: :... : ::..: .:... :: :.: : :.. :... :...::.: : . ::.:. CCDS78 PKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVV 410 420 430 440 450 460 310 320 330 340 350 360 pF1KE2 FSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLC :::.:.: :::::::: .: ..::.:: . : . .. : :. :.: :. :. . : CCDS78 FSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTY 470 480 490 500 510 520 370 pF1KE2 ELSCSTDYRMR CCDS78 GLQ 530 >>CCDS74425.1 PRMT1 gene_id:3276|Hs108|chr19 (285 aa) initn: 1113 init1: 1032 opt: 1032 Z-score: 1333.6 bits: 255.0 E(32554): 5.8e-68 Smith-Waterman score: 1714; 76.8% identity (76.8% similar) in 371 aa overlap (1-371:1-285) 10 20 30 40 50 60 pF1KE2 MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHF :::::::::::: :::::::::::::::::::::::::::::: CCDS74 MAAAEAANCIME------------------VSCGQAESSEKPNAEDMTSKDYYFDSYAHF 10 20 30 40 70 80 90 100 110 120 pF1KE2 GIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 GIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE2 SISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 SISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYA 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE2 RDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVV ::::: CCDS74 RDKWL------------------------------------------------------- 250 260 270 280 290 300 pF1KE2 DPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTG ::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 -------------EVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTG 170 180 190 200 210 310 320 330 340 350 360 pF1KE2 FSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 FSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLC 220 230 240 250 260 270 370 pF1KE2 ELSCSTDYRMR ::::::::::: CCDS74 ELSCSTDYRMR 280 >>CCDS12250.1 CARM1 gene_id:10498|Hs108|chr19 (608 aa) initn: 518 init1: 320 opt: 641 Z-score: 824.5 bits: 161.9 E(32554): 1.3e-39 Smith-Waterman score: 641; 36.4% identity (68.5% similar) in 321 aa overlap (48-357:144-460) 20 30 40 50 60 70 pF1KE2 LANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYR .: ::. :.... ...:..: ::: ::. CCDS12 PNDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQ 120 130 140 150 160 170 80 90 100 110 120 130 pF1KE2 NSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDH ....:. ::::.::::: :.::: .:::.:::::. ..: :.....: .::.:.: CCDS12 RAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTD 180 190 200 210 220 230 140 150 160 170 180 190 pF1KE2 VVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRAT ...: :::::: :: :.::::::: ::: :: : ::.. :.:. :.: :.: .:: . CCDS12 RIVVIPGKVEEVSLP-EQVDIIISEPMGYMLFNERMLESYLHAK-KYLKPSGNMFPTIGD 240 250 260 270 280 290 200 210 220 230 240 pF1KE2 LYVTAIEDRQ-YKDY--KIHWW--ENVYGFDMSCIKDVAIKE----PLVDVVDPKQLVTN .... . :.: : . : ..: . .: :.: .. .:. : :.::. : . :... CCDS12 VHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAK 300 310 320 330 340 350 250 260 270 280 290 300 pF1KE2 ACLIK-EVDIYTVKVEDL-TFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPE . .: :.. .: :: . :: ... .. ::.:. .:.. : . .::.: CCDS12 S--VKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPT 360 370 380 390 400 310 320 330 340 350 360 pF1KE2 SPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCST : ::: :. ... : .:.:. . :: . : ... :.... ..: : CCDS12 EPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDL 410 420 430 440 450 460 370 pF1KE2 DYRMR CCDS12 KNPFFRYTGTTPSPPPGSHYTSPSENMWNTGSTYNLSSGMAVAGMPTAYDLSSVIASGSS 470 480 490 500 510 520 >>CCDS13737.1 PRMT2 gene_id:3275|Hs108|chr21 (433 aa) initn: 533 init1: 415 opt: 618 Z-score: 797.1 bits: 156.4 E(32554): 4.5e-38 Smith-Waterman score: 728; 35.6% identity (69.7% similar) in 320 aa overlap (43-351:92-409) 20 30 40 50 60 70 pF1KE2 NFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVR . :: . . :: ::. . .: ::: :. : CCDS13 QTTADWWWGERAGCCGYIPANHVGKHVDEYDPEDTWQDEEYFGSYGTLKLHLEMLADQPR 70 80 90 100 110 120 80 90 100 110 120 130 pF1KE2 TLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAK-AGARKVIGIECSSISDYAVKIVK : :.. ...:.. . :::.:::: ::::. .: :. : : : ..: : ..... ..: CCDS13 TTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLVL 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE2 ANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLI : . ..:. . :::.: :: ::::...::::: ::..: :....::::: :: ::.: CCDS13 QNGFADIITVYQQKVEDVVLP-EKVDVLVSEWMGTCLLFEFMIESILYARDAWLKEDGVI 190 200 210 220 230 240 200 210 220 230 240 pF1KE2 FPDRATLY-VTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKE----PLVD-VVDPKQL .: :.:. : :..:.. :. .:.:.: :..: .:..:.:: : . .. :.. CCDS13 WPTMAALHLVPCSADKDYRS-KVLFWDNAYEFNLSALKSLAVKEFFSKPKYNHILKPEDC 250 260 270 280 290 250 260 270 280 290 300 pF1KE2 VTNACLIKEVDIYTVKVEDL-TFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTG---F ... : : ..:. ::.. :: :. . . ..... .:...:.:...: .. . CCDS13 LSEPCTILQLDMRTVQISDLETLRGELRFDIRKAGTLHGFTAWFSVHFQSLQEGQPPQVL 300 310 320 330 340 350 310 320 330 340 350 360 pF1KE2 STSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCE ::.: : ::::::.:.:.: . :.::. . :.. .. : : .. .. CCDS13 STGPFHPTTHWKQTLFMMDDPVPVHTGDVVTGSVVLQRNPVWRRHMSVALSWAVTSRQDP 360 370 380 390 400 410 370 pF1KE2 LSCSTDYRMR CCDS13 TSQKVGEKVFPIWR 420 430 >>CCDS41360.2 PRMT6 gene_id:55170|Hs108|chr1 (375 aa) initn: 630 init1: 294 opt: 557 Z-score: 719.4 bits: 141.8 E(32554): 9.5e-34 Smith-Waterman score: 648; 34.7% identity (64.7% similar) in 334 aa overlap (29-347:22-353) 10 20 30 40 50 pF1KE2 MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESS-EKPNAEDMTSKDYYFDSYAH :: . .. :.. :.: . :.. :. CCDS41 MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSD 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 FGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIEC ..::::. :.::: .:: ....: .. :.:::::.::::: .: :.::::.: ..: CCDS41 VSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 SSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLY :.: . : ..:. : :. : .. : :: :::: :.:: :.:::::: :..::::..::. CCDS41 SAIWQQAREVVRFNGLEDRVHVLPGPVETVELP-EQVDAIVSEWMGYGLLHESMLSSVLH 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 ARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENV---YGFDMSCIKDVAIK--- :: ::: ::..: : :... : : :. .... .: .: :: ::::.. : . CCDS41 ARTKWLKEGGLLLPASAELFIAPISD-QMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLM 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 ---EPLVDVVDPKQLVTNACLIKEVDIYTVKVE---DLTFTSPFCLQVKRNDYVHALVAY : .:. .. ..... . .... . .: . . : . . .:... . CCDS41 GHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIW 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE2 FNIEFT--RCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNR :.. : . .: .:::: : :::::...:... . :. .. : : . :. : : CCDS41 FQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPR 300 310 320 330 340 350 350 360 370 pF1KE2 DLDFTIDLDFKGQLCELSCSTDYRMR : CCDS41 RLRVLLRYKVGDQEEKTKDFAMED 360 370 371 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 03:05:24 2016 done: Tue Nov 8 03:05:24 2016 Total Scan time: 1.860 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]