FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2533, 526 aa 1>>>pF1KE2533 526 - 526 aa - 526 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2357+/-0.000512; mu= 10.0108+/- 0.032 mean_var=228.7199+/-48.037, 0's: 0 Z-trim(114.6): 383 B-trim: 7 in 2/57 Lambda= 0.084805 statistics sampled from 24082 (24553) to 24082 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.644), E-opt: 0.2 (0.288), width: 16 Scan time: 8.600 The best scores are: opt bits E(85289) NP_001703 (OMIM: 109770) carcinoembryonic antigen- ( 526) 3494 441.4 3.1e-123 NP_001192273 (OMIM: 109770) carcinoembryonic antig ( 468) 3067 389.1 1.5e-107 NP_001020083 (OMIM: 109770) carcinoembryonic antig ( 464) 3051 387.1 6e-107 XP_011525508 (OMIM: 109770) PREDICTED: carcinoembr ( 351) 2162 278.2 2.8e-74 NP_001171744 (OMIM: 109770) carcinoembryonic antig ( 461) 2157 277.8 5e-74 NP_001171745 (OMIM: 109770) carcinoembryonic antig ( 368) 2147 276.4 1e-73 NP_001171742 (OMIM: 109770) carcinoembryonic antig ( 430) 2147 276.5 1.1e-73 NP_004354 (OMIM: 114890) carcinoembryonic antigen- ( 702) 2050 264.9 5.7e-70 NP_001278413 (OMIM: 114890) carcinoembryonic antig ( 702) 2050 264.9 5.7e-70 XP_016881634 (OMIM: 114890) PREDICTED: carcinoembr ( 701) 2048 264.7 6.7e-70 NP_001295327 (OMIM: 114890) carcinoembryonic antig ( 701) 2048 264.7 6.7e-70 XP_005258470 (OMIM: 114890) PREDICTED: carcinoembr ( 524) 2044 264.0 7.9e-70 XP_011524624 (OMIM: 114890) PREDICTED: carcinoembr ( 524) 2027 261.9 3.3e-69 NP_002474 (OMIM: 163980) carcinoembryonic antigen- ( 344) 1832 237.8 3.9e-62 XP_011525292 (OMIM: 163980) PREDICTED: carcinoembr ( 324) 1822 236.6 8.8e-62 NP_001807 (OMIM: 615747) carcinoembryonic antigen- ( 349) 1725 224.8 3.4e-58 XP_016881684 (OMIM: 615747) PREDICTED: carcinoembr ( 349) 1725 224.8 3.4e-58 XP_016881685 (OMIM: 615747) PREDICTED: carcinoembr ( 331) 1719 224.0 5.5e-58 XP_016881683 (OMIM: 615747) PREDICTED: carcinoembr ( 368) 1719 224.1 5.9e-58 XP_011524642 (OMIM: 615747) PREDICTED: carcinoembr ( 415) 1719 224.1 6.4e-58 XP_016881635 (OMIM: 114890) PREDICTED: carcinoembr ( 617) 1404 185.8 3.2e-46 XP_016881687 (OMIM: 615747) PREDICTED: carcinoembr ( 255) 1289 171.2 3.2e-42 XP_011524643 (OMIM: 615747) PREDICTED: carcinoembr ( 255) 1289 171.2 3.2e-42 XP_011524644 (OMIM: 615747) PREDICTED: carcinoembr ( 255) 1289 171.2 3.2e-42 XP_011525288 (OMIM: 176397) PREDICTED: pregnancy-s ( 326) 1259 167.7 4.8e-41 NP_001288637 (OMIM: 176398) pregnancy-specific bet ( 333) 1247 166.2 1.3e-40 XP_005259132 (OMIM: 176398) PREDICTED: pregnancy-s ( 402) 1247 166.4 1.5e-40 XP_011525428 (OMIM: 176392) PREDICTED: pregnancy-s ( 357) 1219 162.9 1.5e-39 NP_002772 (OMIM: 176394) pregnancy-specific beta-1 ( 335) 1218 162.7 1.6e-39 NP_001123486 (OMIM: 176394) pregnancy-specific bet ( 335) 1218 162.7 1.6e-39 XP_016882492 (OMIM: 176394) PREDICTED: pregnancy-s ( 335) 1218 162.7 1.6e-39 NP_112536 (OMIM: 176391) pregnancy-specific beta-1 ( 335) 1212 162.0 2.6e-39 NP_001288636 (OMIM: 176398) pregnancy-specific bet ( 333) 1210 161.7 3.1e-39 XP_016882494 (OMIM: 176398) PREDICTED: pregnancy-s ( 402) 1210 161.8 3.5e-39 NP_001263424 (OMIM: 176393) pregnancy-specific bet ( 326) 1204 161.0 5.1e-39 NP_998798 (OMIM: 176393) pregnancy-specific beta-1 ( 326) 1202 160.7 6e-39 XP_016882490 (OMIM: 176393) PREDICTED: pregnancy-s ( 333) 1202 160.7 6.1e-39 XP_016882491 (OMIM: 176393) PREDICTED: pregnancy-s ( 333) 1200 160.5 7.2e-39 XP_011525427 (OMIM: 176390) PREDICTED: pregnancy-s ( 333) 1198 160.3 8.6e-39 NP_001317453 (OMIM: 176390) pregnancy-specific bet ( 326) 1192 159.5 1.4e-38 XP_005259122 (OMIM: 176390) PREDICTED: pregnancy-s ( 333) 1190 159.3 1.7e-38 NP_002776 (OMIM: 176401) pregnancy-specific beta-1 ( 335) 1186 158.8 2.4e-38 XP_016882489 (OMIM: 176393) PREDICTED: pregnancy-s ( 342) 1124 151.2 4.6e-36 XP_016882487 (OMIM: 176393) PREDICTED: pregnancy-s ( 349) 1124 151.2 4.7e-36 XP_016882488 (OMIM: 176393) PREDICTED: pregnancy-s ( 349) 1122 151.0 5.6e-36 XP_016881686 (OMIM: 615747) PREDICTED: carcinoembr ( 295) 1015 137.8 4.4e-32 XP_011525429 (OMIM: 176392) PREDICTED: pregnancy-s ( 272) 908 124.7 3.6e-28 NP_001264092 (OMIM: 609142) carcinoembryonic antig ( 212) 792 110.3 5.8e-24 NP_001806 (OMIM: 609142) carcinoembryonic antigen- ( 252) 792 110.4 6.5e-24 NP_002773 (OMIM: 176395) pregnancy-specific beta-1 ( 435) 750 105.6 3.2e-22 >>NP_001703 (OMIM: 109770) carcinoembryonic antigen-rela (526 aa) initn: 3494 init1: 3494 opt: 3494 Z-score: 2333.4 bits: 441.4 E(85289): 3.1e-123 Smith-Waterman score: 3494; 100.0% identity (100.0% similar) in 526 aa overlap (1-526:1-526) 10 20 30 40 50 60 pF1KE2 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHTQDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHTQDH 430 440 450 460 470 480 490 500 510 520 pF1KE2 SNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ :::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ 490 500 510 520 >>NP_001192273 (OMIM: 109770) carcinoembryonic antigen-r (468 aa) initn: 3067 init1: 3067 opt: 3067 Z-score: 2051.6 bits: 389.1 E(85289): 1.5e-107 Smith-Waterman score: 3067; 98.7% identity (99.4% similar) in 467 aa overlap (1-467:1-467) 10 20 30 40 50 60 pF1KE2 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHTQDH :::::::::::::::::::::::::::::::::::::::.. . :: NP_001 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRTTPMTHLTR 430 440 450 460 490 500 510 520 pF1KE2 SNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ >>NP_001020083 (OMIM: 109770) carcinoembryonic antigen-r (464 aa) initn: 3051 init1: 3051 opt: 3051 Z-score: 2041.1 bits: 387.1 E(85289): 6e-107 Smith-Waterman score: 3051; 100.0% identity (100.0% similar) in 458 aa overlap (1-458:1-458) 10 20 30 40 50 60 pF1KE2 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHTQDH :::::::::::::::::::::::::::::::::::::: NP_001 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGSSGPLQ 430 440 450 460 490 500 510 520 pF1KE2 SNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ >>XP_011525508 (OMIM: 109770) PREDICTED: carcinoembryoni (351 aa) initn: 2151 init1: 2151 opt: 2162 Z-score: 1454.6 bits: 278.2 E(85289): 2.8e-74 Smith-Waterman score: 2162; 98.2% identity (99.4% similar) in 329 aa overlap (1-329:1-328) 10 20 30 40 50 60 pF1KE2 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :::::::::::::::::::: :::... . XP_011 ANNSVTGCNRTTVKTIIVTE-SPVLGEDEAVPGQHHPQHKPCQEGGCWDVLV 310 320 330 340 350 >>NP_001171744 (OMIM: 109770) carcinoembryonic antigen-r (461 aa) initn: 2846 init1: 2151 opt: 2157 Z-score: 1450.0 bits: 277.8 E(85289): 5e-74 Smith-Waterman score: 2747; 84.2% identity (85.9% similar) in 526 aa overlap (1-526:1-461) 10 20 30 40 50 60 pF1KE2 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :::::::::::::::::::: . ::: NP_001 ANNSVTGCNRTTVKTIIVTERQ----------------------NLTM------------ 310 320 370 380 390 400 410 420 pF1KE2 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP :: : :... : ... : : .:: : . :::: NP_001 -----LP--------------------RLDSNS-WAQAILP-SVSQSAEI----TDNALP 330 340 350 430 440 450 460 470 480 pF1KE2 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHTQDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHTQDH 360 370 380 390 400 410 490 500 510 520 pF1KE2 SNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ :::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ 420 430 440 450 460 >>NP_001171745 (OMIM: 109770) carcinoembryonic antigen-r (368 aa) initn: 2199 init1: 2147 opt: 2147 Z-score: 1444.5 bits: 276.4 E(85289): 1e-73 Smith-Waterman score: 2210; 78.8% identity (79.0% similar) in 458 aa overlap (1-458:1-362) 10 20 30 40 50 60 pF1KE2 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :::::::::::::::::::. NP_001 ANNSVTGCNRTTVKTIIVTD---------------------------------------- 310 320 370 380 390 400 410 420 pF1KE2 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP :::: NP_001 --------------------------------------------------------NALP 430 440 450 460 470 480 pF1KE2 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHTQDH :::::::::::::::::::::::::::::::::::::: NP_001 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGSSGPLQ 330 340 350 360 490 500 510 520 pF1KE2 SNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ >>NP_001171742 (OMIM: 109770) carcinoembryonic antigen-r (430 aa) initn: 2199 init1: 2147 opt: 2147 Z-score: 1443.7 bits: 276.5 E(85289): 1.1e-73 Smith-Waterman score: 2653; 81.6% identity (81.7% similar) in 526 aa overlap (1-526:1-430) 10 20 30 40 50 60 pF1KE2 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :::::::::::::::::::. NP_001 ANNSVTGCNRTTVKTIIVTD---------------------------------------- 310 320 370 380 390 400 410 420 pF1KE2 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP :::: NP_001 --------------------------------------------------------NALP 430 440 450 460 470 480 pF1KE2 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHTQDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHTQDH 330 340 350 360 370 380 490 500 510 520 pF1KE2 SNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ :::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ 390 400 410 420 430 >>NP_004354 (OMIM: 114890) carcinoembryonic antigen-rela (702 aa) initn: 2366 init1: 1809 opt: 2050 Z-score: 1377.2 bits: 264.9 E(85289): 5.7e-70 Smith-Waterman score: 2050; 63.0% identity (79.3% similar) in 511 aa overlap (5-512:5-510) 10 20 30 40 50 60 pF1KE2 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ ::: :: .::: :::::::::::::::::.:: :: ::::::::::::::::::: NP_004 MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY .::::::::::::::::::.::.::::::::::: :::: :::::::::::. ::::::: NP_004 HLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI ::.:::::::::::::::.:::::::::::::::.::::::::::::::::::.:::::. NP_004 TLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP ::::::::::::::::::::::..::::::. :.:: :::::: ::: : ::: ::::.: NP_004 NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::: .: :: : ::.:::.:::::::::::..::::::::::::::::::::::::::. NP_004 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :.:: :: ::::: :: : : :: : ..... . :.:.: ::: . . . :. NP_004 AHNSDTGLNRTTVTTITVYAEPP---KPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWW 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP .::::: : :..::. : ::.. : :.:.: : : . : .: ..:::..::: :. : NP_004 VNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLYG--P 360 370 380 390 400 410 430 440 450 460 470 pF1KE2 QENGLSPGAI---AGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHT .. .::. :. ... .: : .: :. . ... ... . :. NP_004 DDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLY 420 430 440 450 460 470 480 490 500 510 520 pF1KE2 QDHSNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ ..:. . ...: .:.. :. : :.. : NP_004 TCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWW 480 490 500 510 520 530 NP_004 VNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDT 540 550 560 570 580 590 >-- initn: 875 init1: 779 opt: 779 Z-score: 536.8 bits: 109.4 E(85289): 3.7e-23 Smith-Waterman score: 779; 70.7% identity (84.1% similar) in 164 aa overlap (156-319:512-675) 130 140 150 160 170 180 pF1KE2 KSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWINNQSL :::::::::::::::.:.::::::.:.::: NP_004 SASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSL 490 500 510 520 530 540 190 200 210 220 230 240 pF1KE2 PVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTPTISPS :::::::::::::::::..:::::. : : ::: :::::::::::.: :::::: ::: NP_004 PVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPP 550 560 570 580 590 600 250 260 270 280 290 300 pF1KE2 DTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCHANNSV :. : ::::.:::..:::: :::: ::: :: :: ::: .:: ::.:.:.: ..: . NP_004 DSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLA 610 620 630 640 650 660 310 320 330 340 350 360 pF1KE2 TGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWFFKNQS :: : . ::.: :. NP_004 TGRNNSIVKSITVSASGTSPGLSAGATVGIMIGVLVGVALI 670 680 690 700 >>NP_001278413 (OMIM: 114890) carcinoembryonic antigen-r (702 aa) initn: 2366 init1: 1809 opt: 2050 Z-score: 1377.2 bits: 264.9 E(85289): 5.7e-70 Smith-Waterman score: 2050; 63.0% identity (79.3% similar) in 511 aa overlap (5-512:5-510) 10 20 30 40 50 60 pF1KE2 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ ::: :: .::: :::::::::::::::::.:: :: ::::::::::::::::::: NP_001 MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY .::::::::::::::::::.::.::::::::::: :::: :::::::::::. ::::::: NP_001 HLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI ::.:::::::::::::::.:::::::::::::::.::::::::::::::::::.:::::. NP_001 TLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP ::::::::::::::::::::::..::::::. :.:: :::::: ::: : ::: ::::.: NP_001 NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::: .: :: : ::.:::.:::::::::::..::::::::::::::::::::::::::. NP_001 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :.:: :: ::::: :: : : :: : ..... . :.:.: ::: . . . :. NP_001 AHNSDTGLNRTTVTTITVYAEPP---KPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWW 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP .::::: : :..::. : ::.. : :.:.: : : . : .: ..:::..::: :. : NP_001 VNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLYG--P 360 370 380 390 400 410 430 440 450 460 470 pF1KE2 QENGLSPGAI---AGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHT .. .::. :. ... .: : .: :. . ... ... . :. NP_001 DDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLY 420 430 440 450 460 470 480 490 500 510 520 pF1KE2 QDHSNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ ..:. . ...: .:.. :. : :.. : NP_001 TCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWW 480 490 500 510 520 530 NP_001 VNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDT 540 550 560 570 580 590 >-- initn: 875 init1: 779 opt: 779 Z-score: 536.8 bits: 109.4 E(85289): 3.7e-23 Smith-Waterman score: 779; 70.7% identity (84.1% similar) in 164 aa overlap (156-319:512-675) 130 140 150 160 170 180 pF1KE2 KSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWINNQSL :::::::::::::::.:.::::::.:.::: NP_001 SASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSL 490 500 510 520 530 540 190 200 210 220 230 240 pF1KE2 PVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTPTISPS :::::::::::::::::..:::::. : : ::: :::::::::::.: :::::: ::: NP_001 PVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPP 550 560 570 580 590 600 250 260 270 280 290 300 pF1KE2 DTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCHANNSV :. : ::::.:::..:::: :::: ::: :: :: ::: .:: ::.:.:.: ..: . NP_001 DSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLA 610 620 630 640 650 660 310 320 330 340 350 360 pF1KE2 TGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWFFKNQS :: : . ::.: :. NP_001 TGRNNSIVKSITVSASGTSPGLSAGATVGIMIGVLVGVALI 670 680 690 700 >>XP_016881634 (OMIM: 114890) PREDICTED: carcinoembryoni (701 aa) initn: 2367 init1: 1810 opt: 2048 Z-score: 1375.9 bits: 264.7 E(85289): 6.7e-70 Smith-Waterman score: 2048; 63.2% identity (79.5% similar) in 511 aa overlap (5-512:5-509) 10 20 30 40 50 60 pF1KE2 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ ::: :: .::: :::::::::::::::::.:: :: ::::::::::::::::::: XP_016 MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY .::::::::::::::::::.::.::::::::::: :::: :::::::::::. ::::::: XP_016 HLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI ::.:::::::::::::::.:::::::::::::::.::::::::::::::::::.:::::. XP_016 TLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP ::::::::::::::::::::::..::::::. :.:: :::::: ::: : ::: ::::.: XP_016 NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::: .: :: : ::.:::.:::::::::::..::::::::::::::::::::::::::. XP_016 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :.:: :: ::::: :: : : : :: : ..... . :.:.: ::: . . . :. XP_016 AHNSDTGLNRTTVTTITVYE-PP---KPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWW 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP .::::: : :..::. : ::.. : :.:.: : : . : .: ..:::..::: :. : XP_016 VNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLYG--P 360 370 380 390 400 410 430 440 450 460 470 pF1KE2 QENGLSPGAI---AGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHT .. .::. :. ... .: : .: :. . ... ... . :. XP_016 DDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLY 420 430 440 450 460 470 480 490 500 510 520 pF1KE2 QDHSNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ ..:. . ...: .:.. :. : :.. : XP_016 TCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWW 480 490 500 510 520 530 XP_016 VNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDT 540 550 560 570 580 590 >-- initn: 875 init1: 779 opt: 779 Z-score: 536.8 bits: 109.4 E(85289): 3.7e-23 Smith-Waterman score: 779; 70.7% identity (84.1% similar) in 164 aa overlap (156-319:511-674) 130 140 150 160 170 180 pF1KE2 KSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWINNQSL :::::::::::::::.:.::::::.:.::: XP_016 SASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSL 490 500 510 520 530 540 190 200 210 220 230 240 pF1KE2 PVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTPTISPS :::::::::::::::::..:::::. : : ::: :::::::::::.: :::::: ::: XP_016 PVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPP 550 560 570 580 590 600 250 260 270 280 290 300 pF1KE2 DTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCHANNSV :. : ::::.:::..:::: :::: ::: :: :: ::: .:: ::.:.:.: ..: . XP_016 DSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLA 610 620 630 640 650 660 310 320 330 340 350 360 pF1KE2 TGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWFFKNQS :: : . ::.: :. XP_016 TGRNNSIVKSITVSASGTSPGLSAGATVGIMIGVLVGVALI 670 680 690 700 526 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 03:32:40 2016 done: Tue Nov 8 03:32:42 2016 Total Scan time: 8.600 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]