FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2534, 344 aa 1>>>pF1KE2534 344 - 344 aa - 344 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1639+/-0.000449; mu= 7.4224+/- 0.028 mean_var=232.0490+/-48.822, 0's: 0 Z-trim(116.4): 298 B-trim: 706 in 1/55 Lambda= 0.084195 statistics sampled from 27077 (27529) to 27077 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.687), E-opt: 0.2 (0.323), width: 16 Scan time: 7.000 The best scores are: opt bits E(85289) NP_002474 (OMIM: 163980) carcinoembryonic antigen- ( 344) 2288 291.2 2.1e-78 XP_011525292 (OMIM: 163980) PREDICTED: carcinoembr ( 324) 2147 274.1 2.9e-73 NP_001171745 (OMIM: 109770) carcinoembryonic antig ( 368) 1867 240.2 5.5e-63 NP_001171742 (OMIM: 109770) carcinoembryonic antig ( 430) 1867 240.2 6e-63 XP_005258470 (OMIM: 114890) PREDICTED: carcinoembr ( 524) 1833 236.2 1.2e-61 NP_001020083 (OMIM: 109770) carcinoembryonic antig ( 464) 1832 236.0 1.2e-61 XP_011525508 (OMIM: 109770) PREDICTED: carcinoembr ( 351) 1830 235.6 1.2e-61 NP_001192273 (OMIM: 109770) carcinoembryonic antig ( 468) 1832 236.0 1.2e-61 NP_001703 (OMIM: 109770) carcinoembryonic antigen- ( 526) 1832 236.1 1.3e-61 NP_004354 (OMIM: 114890) carcinoembryonic antigen- ( 702) 1833 236.4 1.4e-61 NP_001278413 (OMIM: 114890) carcinoembryonic antig ( 702) 1833 236.4 1.4e-61 NP_001295327 (OMIM: 114890) carcinoembryonic antig ( 701) 1827 235.7 2.4e-61 XP_016881634 (OMIM: 114890) PREDICTED: carcinoembr ( 701) 1827 235.7 2.4e-61 NP_001171744 (OMIM: 109770) carcinoembryonic antig ( 461) 1820 234.6 3.3e-61 NP_001807 (OMIM: 615747) carcinoembryonic antigen- ( 349) 1792 231.0 2.9e-60 XP_016881684 (OMIM: 615747) PREDICTED: carcinoembr ( 349) 1792 231.0 2.9e-60 XP_011524624 (OMIM: 114890) PREDICTED: carcinoembr ( 524) 1745 225.5 2e-58 XP_016881685 (OMIM: 615747) PREDICTED: carcinoembr ( 331) 1707 220.7 3.7e-57 XP_016881683 (OMIM: 615747) PREDICTED: carcinoembr ( 368) 1707 220.7 3.9e-57 XP_011524642 (OMIM: 615747) PREDICTED: carcinoembr ( 415) 1707 220.8 4.2e-57 XP_016881635 (OMIM: 114890) PREDICTED: carcinoembr ( 617) 1371 180.2 1e-44 XP_011524644 (OMIM: 615747) PREDICTED: carcinoembr ( 255) 1278 168.4 1.5e-41 XP_016881687 (OMIM: 615747) PREDICTED: carcinoembr ( 255) 1278 168.4 1.5e-41 XP_011524643 (OMIM: 615747) PREDICTED: carcinoembr ( 255) 1278 168.4 1.5e-41 NP_112536 (OMIM: 176391) pregnancy-specific beta-1 ( 335) 1257 166.0 1e-40 NP_001288637 (OMIM: 176398) pregnancy-specific bet ( 333) 1253 165.5 1.5e-40 XP_005259132 (OMIM: 176398) PREDICTED: pregnancy-s ( 402) 1254 165.7 1.5e-40 XP_011525288 (OMIM: 176397) PREDICTED: pregnancy-s ( 326) 1246 164.7 2.6e-40 XP_016882492 (OMIM: 176394) PREDICTED: pregnancy-s ( 335) 1237 163.6 5.7e-40 NP_002772 (OMIM: 176394) pregnancy-specific beta-1 ( 335) 1237 163.6 5.7e-40 NP_001123486 (OMIM: 176394) pregnancy-specific bet ( 335) 1237 163.6 5.7e-40 XP_011525428 (OMIM: 176392) PREDICTED: pregnancy-s ( 357) 1226 162.3 1.5e-39 XP_016882490 (OMIM: 176393) PREDICTED: pregnancy-s ( 333) 1224 162.0 1.7e-39 XP_016882491 (OMIM: 176393) PREDICTED: pregnancy-s ( 333) 1223 161.9 1.8e-39 NP_001288636 (OMIM: 176398) pregnancy-specific bet ( 333) 1222 161.7 2e-39 XP_016882494 (OMIM: 176398) PREDICTED: pregnancy-s ( 402) 1223 162.0 2.1e-39 NP_002776 (OMIM: 176401) pregnancy-specific beta-1 ( 335) 1221 161.6 2.2e-39 NP_001263424 (OMIM: 176393) pregnancy-specific bet ( 326) 1214 160.8 3.9e-39 NP_998798 (OMIM: 176393) pregnancy-specific beta-1 ( 326) 1213 160.6 4.2e-39 XP_011525427 (OMIM: 176390) PREDICTED: pregnancy-s ( 333) 1202 159.3 1.1e-38 XP_005259122 (OMIM: 176390) PREDICTED: pregnancy-s ( 333) 1200 159.1 1.3e-38 NP_001317453 (OMIM: 176390) pregnancy-specific bet ( 326) 1192 158.1 2.5e-38 XP_016882487 (OMIM: 176393) PREDICTED: pregnancy-s ( 349) 1131 150.7 4.4e-36 XP_016882488 (OMIM: 176393) PREDICTED: pregnancy-s ( 349) 1130 150.6 4.7e-36 XP_016882489 (OMIM: 176393) PREDICTED: pregnancy-s ( 342) 1120 149.4 1.1e-35 XP_016881686 (OMIM: 615747) PREDICTED: carcinoembr ( 295) 1004 135.2 1.7e-31 XP_011525429 (OMIM: 176392) PREDICTED: pregnancy-s ( 272) 906 123.2 6.3e-28 NP_001264092 (OMIM: 609142) carcinoembryonic antig ( 212) 809 111.3 1.9e-24 NP_001806 (OMIM: 609142) carcinoembryonic antigen- ( 252) 809 111.4 2.1e-24 NP_001027020 (OMIM: 176395) pregnancy-specific bet ( 424) 730 102.1 2.3e-21 >>NP_002474 (OMIM: 163980) carcinoembryonic antigen-rela (344 aa) initn: 2288 init1: 2288 opt: 2288 Z-score: 1528.5 bits: 291.2 E(85289): 2.1e-78 Smith-Waterman score: 2288; 100.0% identity (100.0% similar) in 344 aa overlap (1-344:1-344) 10 20 30 40 50 60 pF1KE2 MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ 250 260 270 280 290 300 310 320 330 340 pF1KE2 AHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI :::::::::::::::::::::::::::::::::::::::::::: NP_002 AHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI 310 320 330 340 >>XP_011525292 (OMIM: 163980) PREDICTED: carcinoembryoni (324 aa) initn: 2147 init1: 2147 opt: 2147 Z-score: 1436.2 bits: 274.1 E(85289): 2.9e-73 Smith-Waterman score: 2147; 100.0% identity (100.0% similar) in 319 aa overlap (1-319:1-319) 10 20 30 40 50 60 pF1KE2 MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ 250 260 270 280 290 300 310 320 330 340 pF1KE2 AHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI ::::::::::::::::::: XP_011 AHNSATGLNRTTVTMITVSDWTRP 310 320 >>NP_001171745 (OMIM: 109770) carcinoembryonic antigen-r (368 aa) initn: 1929 init1: 1825 opt: 1867 Z-score: 1251.8 bits: 240.2 E(85289): 5.5e-63 Smith-Waterman score: 1867; 82.5% identity (90.5% similar) in 348 aa overlap (1-344:1-348) 10 20 30 40 50 60 pF1KE2 MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ :: ::: :..:::. .::::::::::::::::.:: :: :::::::::::::.::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY . .::::::::::::: ::::.::::::::::: ::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV ::::::::::::::::::::::::::::::::::::::::::::::::::.:.::::::. NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVP :.::::::::::::::: ::::::: :::.: ::::::::.:::::::::::: ::::.: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ ::::: . :::: ::.:::.:::::::::::.::::::::::::::::::::::::: :. NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 pF1KE2 AHNSATGLNRTTVTMITVSGSA-PV---LSAVATVGITIGVLARVALI :.::.:: ::::: : :. .: : :: : .::.:::.: :::: NP_001 ANNSVTGCNRTTVKTIIVTDNALPQENGLSPGAIAGIVIGVVALVALIAVALACFLHFGK 310 320 330 340 350 360 NP_001 TGSSGPLQ >>NP_001171742 (OMIM: 109770) carcinoembryonic antigen-r (430 aa) initn: 1929 init1: 1825 opt: 1867 Z-score: 1251.0 bits: 240.2 E(85289): 6e-63 Smith-Waterman score: 1867; 82.5% identity (90.5% similar) in 348 aa overlap (1-344:1-348) 10 20 30 40 50 60 pF1KE2 MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ :: ::: :..:::. .::::::::::::::::.:: :: :::::::::::::.::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY . .::::::::::::: ::::.::::::::::: ::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV ::::::::::::::::::::::::::::::::::::::::::::::::::.:.::::::. NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVP :.::::::::::::::: ::::::: :::.: ::::::::.:::::::::::: ::::.: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ ::::: . :::: ::.:::.:::::::::::.::::::::::::::::::::::::: :. NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 pF1KE2 AHNSATGLNRTTVTMITVSGSA-PV---LSAVATVGITIGVLARVALI :.::.:: ::::: : :. .: : :: : .::.:::.: :::: NP_001 ANNSVTGCNRTTVKTIIVTDNALPQENGLSPGAIAGIVIGVVALVALIAVALACFLHFGK 310 320 330 340 350 360 NP_001 TGRASDQRDLTEHKPSVSNHTQDHSNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTAT 370 380 390 400 410 420 >>XP_005258470 (OMIM: 114890) PREDICTED: carcinoembryoni (524 aa) initn: 1833 init1: 1833 opt: 1833 Z-score: 1227.8 bits: 236.2 E(85289): 1.2e-61 Smith-Waterman score: 1833; 83.9% identity (92.6% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE2 MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ : ::::: : .::...::::::::::::::::::::::::::::::::::::.::::: XP_005 MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY . .::::::::::::: :.::::::::::::::::::: :::::::::::. ::::::: XP_005 HLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV ::.:::::::::::::::.:::::::::::::::.:::::::::::::::.:..:::::: XP_005 TLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVP :.::::::::::::::: ::::..: :::..::.:: :::.:: ::: : ::::::::.: XP_005 NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ :::: ...:: :::::::::::::::::::::.:::::::::::::::::::::::: :: XP_005 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQ 250 260 270 280 290 300 310 320 330 340 pF1KE2 AHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI :::: ::::::::: ::: . : XP_005 AHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNN 310 320 330 340 350 360 >-- initn: 931 init1: 896 opt: 972 Z-score: 662.6 bits: 131.6 E(85289): 3.6e-30 Smith-Waterman score: 972; 75.6% identity (86.6% similar) in 201 aa overlap (146-344:324-524) 120 130 140 150 160 170 pF1KE2 DTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTT :: :.:::::::::.::::.:::::.:::: XP_005 SGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTT 300 310 320 330 340 350 180 190 200 210 220 230 pF1KE2 YLWWVNGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLY ::::::.::::::::::::: : ::::::: :::.: ::: ::: :...:::: ::::: XP_005 YLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLY 360 370 380 390 400 410 240 250 260 270 280 290 pF1KE2 GPDVPTISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSG ::: :::::: . :::: ::.:::::::::::::::.:.:..:: :::::: ::: .::: XP_005 GPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSG 420 430 440 450 460 470 300 310 320 330 340 pF1KE2 SYMCQAHNSATGLNRTTVTMITVS--GSAPVLSAVATVGITIGVLARVALI : :::.:::.: .:::: :::: :..: ::: ::::: ::::. :::: XP_005 LYTCQANNSASGHSRTTVKTITVSASGTSPGLSAGATVGIMIGVLVGVALI 480 490 500 510 520 >>NP_001020083 (OMIM: 109770) carcinoembryonic antigen-r (464 aa) initn: 1936 init1: 1832 opt: 1832 Z-score: 1227.7 bits: 236.0 E(85289): 1.2e-61 Smith-Waterman score: 1832; 84.0% identity (92.3% similar) in 326 aa overlap (1-326:1-326) 10 20 30 40 50 60 pF1KE2 MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ :: ::: :..:::. .::::::::::::::::.:: :: :::::::::::::.::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY . .::::::::::::: ::::.::::::::::: ::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV ::::::::::::::::::::::::::::::::::::::::::::::::::.:.::::::. NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVP :.::::::::::::::: ::::::: :::.: ::::::::.:::::::::::: ::::.: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ ::::: . :::: ::.:::.:::::::::::.::::::::::::::::::::::::: :. NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 pF1KE2 AHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI :.::.:: ::::: : :. .::.. NP_001 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF 310 320 330 340 350 360 >-- initn: 385 init1: 284 opt: 290 Z-score: 215.4 bits: 48.7 E(85289): 2.9e-05 Smith-Waterman score: 290; 44.6% identity (73.3% similar) in 101 aa overlap (146-244:327-427) 120 130 140 150 160 170 pF1KE2 DTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTT ::.:...... . :::.: .:: . . . NP_001 YTCHANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGIS 300 310 320 330 340 350 180 190 200 210 220 230 pF1KE2 YLWWVNGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLY :. ..:::: : :..::.:: ::.. :::.:::.: ::. :: : :.:::. ::: : NP_001 IRWFFKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNY 360 370 380 390 400 410 240 250 260 270 280 290 pF1KE2 G--PDVPTISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNN . :. .:: NP_001 NALPQENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGSSGPLQ 420 430 440 450 460 >>XP_011525508 (OMIM: 109770) PREDICTED: carcinoembryoni (351 aa) initn: 1877 init1: 1822 opt: 1830 Z-score: 1227.7 bits: 235.6 E(85289): 1.2e-61 Smith-Waterman score: 1830; 84.9% identity (92.3% similar) in 325 aa overlap (1-325:1-324) 10 20 30 40 50 60 pF1KE2 MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ :: ::: :..:::. .::::::::::::::::.:: :: :::::::::::::.::::: XP_011 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY . .::::::::::::: ::::.::::::::::: ::::::::::::::::::::::::: XP_011 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV ::::::::::::::::::::::::::::::::::::::::::::::::::.:.::::::. XP_011 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVP :.::::::::::::::: ::::::: :::.: ::::::::.:::::::::::: ::::.: XP_011 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ ::::: . :::: ::.:::.:::::::::::.::::::::::::::::::::::::: :. XP_011 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 pF1KE2 AHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI :.::.:: ::::: : :. : ::: XP_011 ANNSVTGCNRTTVKTIIVTES-PVLGEDEAVPGQHHPQHKPCQEGGCWDVLV 310 320 330 340 350 >>NP_001192273 (OMIM: 109770) carcinoembryonic antigen-r (468 aa) initn: 1936 init1: 1832 opt: 1832 Z-score: 1227.7 bits: 236.0 E(85289): 1.2e-61 Smith-Waterman score: 1832; 84.0% identity (92.3% similar) in 326 aa overlap (1-326:1-326) 10 20 30 40 50 60 pF1KE2 MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ :: ::: :..:::. .::::::::::::::::.:: :: :::::::::::::.::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY . .::::::::::::: ::::.::::::::::: ::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV ::::::::::::::::::::::::::::::::::::::::::::::::::.:.::::::. NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVP :.::::::::::::::: ::::::: :::.: ::::::::.:::::::::::: ::::.: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ ::::: . :::: ::.:::.:::::::::::.::::::::::::::::::::::::: :. NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 pF1KE2 AHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI :.::.:: ::::: : :. .::.. NP_001 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF 310 320 330 340 350 360 >-- initn: 385 init1: 284 opt: 290 Z-score: 215.4 bits: 48.7 E(85289): 2.9e-05 Smith-Waterman score: 290; 44.6% identity (73.3% similar) in 101 aa overlap (146-244:327-427) 120 130 140 150 160 170 pF1KE2 DTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTT ::.:...... . :::.: .:: . . . NP_001 YTCHANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGIS 300 310 320 330 340 350 180 190 200 210 220 230 pF1KE2 YLWWVNGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLY :. ..:::: : :..::.:: ::.. :::.:::.: ::. :: : :.:::. ::: : NP_001 IRWFFKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNY 360 370 380 390 400 410 240 250 260 270 280 290 pF1KE2 G--PDVPTISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNN . :. .:: NP_001 NALPQENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRTTPMTHLTR 420 430 440 450 460 >>NP_001703 (OMIM: 109770) carcinoembryonic antigen-rela (526 aa) initn: 1936 init1: 1832 opt: 1832 Z-score: 1227.1 bits: 236.1 E(85289): 1.3e-61 Smith-Waterman score: 1832; 84.0% identity (92.3% similar) in 326 aa overlap (1-326:1-326) 10 20 30 40 50 60 pF1KE2 MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ :: ::: :..:::. .::::::::::::::::.:: :: :::::::::::::.::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY . .::::::::::::: ::::.::::::::::: ::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV ::::::::::::::::::::::::::::::::::::::::::::::::::.:.::::::. NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVP :.::::::::::::::: ::::::: :::.: ::::::::.:::::::::::: ::::.: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ ::::: . :::: ::.:::.:::::::::::.::::::::::::::::::::::::: :. NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 pF1KE2 AHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI :.::.:: ::::: : :. .::.. NP_001 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF 310 320 330 340 350 360 >-- initn: 385 init1: 284 opt: 290 Z-score: 214.9 bits: 48.8 E(85289): 3.1e-05 Smith-Waterman score: 290; 44.6% identity (73.3% similar) in 101 aa overlap (146-244:327-427) 120 130 140 150 160 170 pF1KE2 DTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTT ::.:...... . :::.: .:: . . . NP_001 YTCHANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGIS 300 310 320 330 340 350 180 190 200 210 220 230 pF1KE2 YLWWVNGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLY :. ..:::: : :..::.:: ::.. :::.:::.: ::. :: : :.:::. ::: : NP_001 IRWFFKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNY 360 370 380 390 400 410 240 250 260 270 280 290 pF1KE2 G--PDVPTISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNN . :. .:: NP_001 NALPQENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNH 420 430 440 450 460 470 >>NP_004354 (OMIM: 114890) carcinoembryonic antigen-rela (702 aa) initn: 1833 init1: 1833 opt: 1833 Z-score: 1226.4 bits: 236.4 E(85289): 1.4e-61 Smith-Waterman score: 1833; 83.9% identity (92.6% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE2 MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ : ::::: : .::...::::::::::::::::::::::::::::::::::::.::::: NP_004 MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY . .::::::::::::: :.::::::::::::::::::: :::::::::::. ::::::: NP_004 HLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV ::.:::::::::::::::.:::::::::::::::.:::::::::::::::.:..:::::: NP_004 TLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVP :.::::::::::::::: ::::..: :::..::.:: :::.:: ::: : ::::::::.: NP_004 NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ :::: ...:: :::::::::::::::::::::.:::::::::::::::::::::::: :: NP_004 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQ 250 260 270 280 290 300 310 320 330 340 pF1KE2 AHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI :::: ::::::::: ::: . : NP_004 AHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNN 310 320 330 340 350 360 >-- initn: 904 init1: 840 opt: 916 Z-score: 624.4 bits: 125.0 E(85289): 4.8e-28 Smith-Waterman score: 916; 72.6% identity (82.1% similar) in 201 aa overlap (146-344:502-702) 120 130 140 150 160 170 pF1KE2 DTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTT :::::::::.:::::::::::::::.:::: NP_004 SGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTT 480 490 500 510 520 530 180 190 200 210 220 230 pF1KE2 YLWWVNGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLY :::::::::::::::::::::: ::::..: :::: .: : ::: .::::::::::.::: NP_004 YLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLY 540 550 560 570 580 590 240 250 260 270 280 290 pF1KE2 GPDVPTISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSG :::.: ::: ..: : :::::::.:::: :::: ::: :: :: ::: .:: ::.: NP_004 GPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNG 600 610 620 630 640 650 300 310 320 330 340 pF1KE2 SYMCQAHNSATGLNRTTVTMITVS--GSAPVLSAVATVGITIGVLARVALI .: : . : ::: : . : :::: :..: ::: ::::: ::::. :::: NP_004 TYACFVSNLATGRNNSIVKSITVSASGTSPGLSAGATVGIMIGVLVGVALI 660 670 680 690 700 >-- initn: 914 init1: 898 opt: 898 Z-score: 612.6 bits: 122.8 E(85289): 2.2e-27 Smith-Waterman score: 898; 75.8% identity (87.1% similar) in 178 aa overlap (146-323:324-501) 120 130 140 150 160 170 pF1KE2 DTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTT :: :.:::::::::.::::.:::::.:::: NP_004 SGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTT 300 310 320 330 340 350 180 190 200 210 220 230 pF1KE2 YLWWVNGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLY ::::::.::::::::::::: : ::::::: :::.: ::: ::: :...:::: ::::: NP_004 YLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLY 360 370 380 390 400 410 240 250 260 270 280 290 pF1KE2 GPDVPTISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSG ::: :::::: . :::: ::.:::::::::::::::.:.:..:: :::::: ::: .::: NP_004 GPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSG 420 430 440 450 460 470 300 310 320 330 340 pF1KE2 SYMCQAHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI : :::.:::.: .:::: ::::. : NP_004 LYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYL 480 490 500 510 520 530 344 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 03:33:21 2016 done: Tue Nov 8 03:33:22 2016 Total Scan time: 7.000 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]