Result of FASTA (omim) for
pF1KE2566
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2566, 570 aa
1>>>pF1KE2566 570 - 570 aa - 570 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0095+/-0.00047; mu= 15.1852+/- 0.029
mean_var=69.8603+/-13.827, 0's: 0 Z-trim(108.7): 32 B-trim: 865 in 1/52
Lambda= 0.153447
statistics sampled from 16812 (16842) to 16812 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.55), E-opt: 0.2 (0.197), width: 16
Scan time: 7.770
The best scores are: opt bits E(85289)
NP_009190 (OMIM: 610035,615285) vacuolar protein s ( 570) 3666 821.2 0
NP_001266283 (OMIM: 610035,615285) vacuolar protei ( 534) 3442 771.7 0
XP_016855653 (OMIM: 610035,615285) PREDICTED: vacu ( 503) 3224 723.4 4.2e-208
NP_001266284 (OMIM: 610035,615285) vacuolar protei ( 447) 2825 635.0 1.5e-181
NP_001266282 (OMIM: 610035,615285) vacuolar protei ( 538) 2259 509.8 9.2e-144
NP_001120868 (OMIM: 601717,613101) syntaxin-bindin ( 590) 328 82.3 4.8e-15
NP_008880 (OMIM: 601717,613101) syntaxin-binding p ( 593) 319 80.3 1.9e-14
NP_001258963 (OMIM: 601717,613101) syntaxin-bindin ( 604) 319 80.3 2e-14
NP_001027392 (OMIM: 602926,612164) syntaxin-bindin ( 594) 293 74.5 1e-12
NP_003156 (OMIM: 602926,612164) syntaxin-binding p ( 603) 293 74.5 1.1e-12
XP_011526514 (OMIM: 601717,613101) PREDICTED: synt ( 439) 289 73.6 1.5e-12
XP_011526512 (OMIM: 601717,613101) PREDICTED: synt ( 597) 290 73.9 1.7e-12
NP_075067 (OMIM: 610034) vacuolar protein sorting- ( 596) 190 51.7 7.7e-06
>>NP_009190 (OMIM: 610035,615285) vacuolar protein sorti (570 aa)
initn: 3666 init1: 3666 opt: 3666 Z-score: 4384.9 bits: 821.2 E(85289): 0
Smith-Waterman score: 3666; 100.0% identity (100.0% similar) in 570 aa overlap (1-570:1-570)
10 20 30 40 50 60
pF1KE2 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDSQNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDSQNR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 EIMKHLKAICFLRPTKENVDYIIQELRRPKYTIYFIYFSNVISKSDVKSLAEADEQEVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 EIMKHLKAICFLRPTKENVDYIIQELRRPKYTIYFIYFSNVISKSDVKSLAEADEQEVVA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 EVQEFYGDYIAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 EVQEFYGDYIAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 SEAAKRLAECVKQVITKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVHELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 SEAAKRLAECVKQVITKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVHELL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GINNNRIDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 GINNNRIDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 EQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 EQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 NDHSSALQNIKRLLQNPKVTEFDAARLVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 NDHSSALQNIKRLLQNPKVTEFDAARLVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 KLVSAVVEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLDHLIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 KLVSAVVEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLDHLIKG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 RLKENLYPYLGPSTLRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 RLKENLYPYLGPSTLRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNT
490 500 510 520 530 540
550 560 570
pF1KE2 KSFLEEVLASGLHSRSKESSQVTSRSASRR
::::::::::::::::::::::::::::::
NP_009 KSFLEEVLASGLHSRSKESSQVTSRSASRR
550 560 570
>>NP_001266283 (OMIM: 610035,615285) vacuolar protein so (534 aa)
initn: 3442 init1: 3442 opt: 3442 Z-score: 4117.4 bits: 771.7 E(85289): 0
Smith-Waterman score: 3442; 100.0% identity (100.0% similar) in 534 aa overlap (37-570:1-534)
10 20 30 40 50 60
pF1KE2 VKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDSQNREIMKHL
::::::::::::::::::::::::::::::
NP_001 MVYTQSEILQKEVYLFERIDSQNREIMKHL
10 20 30
70 80 90 100 110 120
pF1KE2 KAICFLRPTKENVDYIIQELRRPKYTIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAICFLRPTKENVDYIIQELRRPKYTIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFY
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 GDYIAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDYIAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKR
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 LAECVKQVITKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAECVKQVITKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNR
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 IDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPKEQQKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPKEQQKLE
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 SIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSA
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 LQNIKRLLQNPKVTEFDAARLVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYRKLVSAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQNIKRLLQNPKVTEFDAARLVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYRKLVSAV
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 VEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENL
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 YPYLGPSTLRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKSFLEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YPYLGPSTLRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKSFLEE
460 470 480 490 500 510
550 560 570
pF1KE2 VLASGLHSRSKESSQVTSRSASRR
::::::::::::::::::::::::
NP_001 VLASGLHSRSKESSQVTSRSASRR
520 530
>>XP_016855653 (OMIM: 610035,615285) PREDICTED: vacuolar (503 aa)
initn: 3224 init1: 3224 opt: 3224 Z-score: 3857.0 bits: 723.4 E(85289): 4.2e-208
Smith-Waterman score: 3224; 100.0% identity (100.0% similar) in 498 aa overlap (1-498:1-498)
10 20 30 40 50 60
pF1KE2 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDSQNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDSQNR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 EIMKHLKAICFLRPTKENVDYIIQELRRPKYTIYFIYFSNVISKSDVKSLAEADEQEVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIMKHLKAICFLRPTKENVDYIIQELRRPKYTIYFIYFSNVISKSDVKSLAEADEQEVVA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 EVQEFYGDYIAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVQEFYGDYIAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 SEAAKRLAECVKQVITKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVHELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEAAKRLAECVKQVITKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVHELL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GINNNRIDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GINNNRIDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 EQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 NDHSSALQNIKRLLQNPKVTEFDAARLVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDHSSALQNIKRLLQNPKVTEFDAARLVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 KLVSAVVEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLDHLIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLVSAVVEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLDHLIKG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 RLKENLYPYLGPSTLRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNT
::::::::::::::::::
XP_016 RLKENLYPYLGPSTLRDRIASCL
490 500
>>NP_001266284 (OMIM: 610035,615285) vacuolar protein so (447 aa)
initn: 2874 init1: 2825 opt: 2825 Z-score: 3380.5 bits: 635.0 E(85289): 1.5e-181
Smith-Waterman score: 2825; 100.0% identity (100.0% similar) in 437 aa overlap (134-570:11-447)
110 120 130 140 150 160
pF1KE2 KSDVKSLAEADEQEVVAEVQEFYGDYIAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLT
::::::::::::::::::::::::::::::
NP_001 MNVVFAVKQYPHLFSLNILGCCQGRNWDPAQLSRTTQGLT
10 20 30 40
170 180 190 200 210 220
pF1KE2 ALLLSLKKCPMIRYQLSSEAAKRLAECVKQVITKEYELFEFRRTEVPPLLLILDRCDDAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALLLSLKKCPMIRYQLSSEAAKRLAECVKQVITKEYELFEFRRTEVPPLLLILDRCDDAI
50 60 70 80 90 100
230 240 250 260 270 280
pF1KE2 TPLLNQWTYQAMVHELLGINNNRIDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPLLNQWTYQAMVHELLGINNNRIDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEI
110 120 130 140 150 160
290 300 310 320 330 340
pF1KE2 GSNIKNLMEDFQKKKPKEQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSNIKNLMEDFQKKKPKEQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVS
170 180 190 200 210 220
350 360 370 380 390 400
pF1KE2 ERNLLEVSEVEQELACQNDHSSALQNIKRLLQNPKVTEFDAARLVMLYALHYERHSSNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERNLLEVSEVEQELACQNDHSSALQNIKRLLQNPKVTEFDAARLVMLYALHYERHSSNSL
230 240 250 260 270 280
410 420 430 440 450 460
pF1KE2 PGLMMDLRNKGVSEKYRKLVSAVVEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGLMMDLRNKGVSEKYRKLVSAVVEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVY
290 300 310 320 330 340
470 480 490 500 510 520
pF1KE2 TQHQPFLHETLDHLIKGRLKENLYPYLGPSTLRDRPQDIIVFVIGGATYEEALTVYNLNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQHQPFLHETLDHLIKGRLKENLYPYLGPSTLRDRPQDIIVFVIGGATYEEALTVYNLNR
350 360 370 380 390 400
530 540 550 560 570
pF1KE2 TTPGVRIVLGGTTVHNTKSFLEEVLASGLHSRSKESSQVTSRSASRR
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTPGVRIVLGGTTVHNTKSFLEEVLASGLHSRSKESSQVTSRSASRR
410 420 430 440
>>NP_001266282 (OMIM: 610035,615285) vacuolar protein so (538 aa)
initn: 2259 init1: 2259 opt: 2259 Z-score: 2702.0 bits: 509.8 E(85289): 9.2e-144
Smith-Waterman score: 2653; 86.3% identity (86.3% similar) in 505 aa overlap (37-541:1-436)
10 20 30 40 50 60
pF1KE2 VKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDSQNREIMKHL
::::::::::::::::::::::::::::::
NP_001 MVYTQSEILQKEVYLFERIDSQNREIMKHL
10 20 30
70 80 90 100 110 120
pF1KE2 KAICFLRPTKENVDYIIQELRRPKYTIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAICFLRPTKENVDYIIQELRRPKYTIYFIYFSNVISKSDVKSLAEADEQEVVAEVQ---
40 50 60 70 80
130 140 150 160 170 180
pF1KE2 GDYIAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKR
NP_001 ------------------------------------------------------------
190 200 210 220 230 240
pF1KE2 LAECVKQVITKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------QVITKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNR
90 100 110 120 130 140
250 260 270 280 290 300
pF1KE2 IDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPKEQQKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPKEQQKLE
150 160 170 180 190 200
310 320 330 340 350 360
pF1KE2 SIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSA
210 220 230 240 250 260
370 380 390 400 410 420
pF1KE2 LQNIKRLLQNPKVTEFDAARLVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYRKLVSAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQNIKRLLQNPKVTEFDAARLVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYRKLVSAV
270 280 290 300 310 320
430 440 450 460 470 480
pF1KE2 VEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENL
330 340 350 360 370 380
490 500 510 520 530 540
pF1KE2 YPYLGPSTLRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKSFLEE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YPYLGPSTLRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKRDGVS
390 400 410 420 430 440
550 560 570
pF1KE2 VLASGLHSRSKESSQVTSRSASRR
NP_001 LCSPAWFRTPGLKRSTRLSLPKCWDYSFPRGSSGFWTAQPKQGELSSHIKVSEQKMKRWL
450 460 470 480 490 500
>>NP_001120868 (OMIM: 601717,613101) syntaxin-binding pr (590 aa)
initn: 183 init1: 112 opt: 328 Z-score: 391.0 bits: 82.3 E(85289): 4.8e-15
Smith-Waterman score: 443; 23.4% identity (57.1% similar) in 576 aa overlap (23-549:29-579)
10 20 30 40 50
pF1KE2 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFER
:::.::. . :.: .:.:: . . . :
NP_001 MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVED
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 IDSQNREIMKHLKAICFLRPTKENVDYIIQELRRPKYTIYFIYFSNVISKSDVKSLAEAD
:... :: . :.:: .: ::.. . .: : :.:... . . :...
NP_001 INKR-REPIPSLEAIYLLSPTEKALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGRSR
70 80 90 100 110
120 130 140 150 160
pF1KE2 EQEVVAEVQEFYGDYIAVNPHLFSLNI------LGCCQGRNWDPAQLSRTTQGLTALLLS
.:: ..:.. .. . ..:::. : : . :: .: ...: .
NP_001 LAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLCAT
120 130 140 150 160 170
170 180 190 200 210
pF1KE2 LKKCPMIRYQLSSEAAKRLAECVKQVITKEYELFEFRRTEVPPL----------LLILDR
:.. : :::. . : . .::. : ..: : :. ...: : :::.::
NP_001 LQEYPAIRYRKGPEDTAQLAHAV---LAK---LNAFK-ADTPSLGEGPEKTRSQLLIMDR
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE2 CDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGISKDLREVVLSAENDEFYANNMYL
: ..:::.. :.:::...:: :... .. :.:. ...:: :.:..... ..
NP_001 AADPVSPLLHELTFQAMAYDLLDIEQDTYRY-ETTGLSEAREKAVLLDEDDDLWVELRHM
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE2 NFAEIGSNIKNLMEDFQKKKPKEQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGEL
..:...... .:.. : ..: .: .: :.. .....::..: . : :. .. .
NP_001 HIADVSKKVTELLRTFCESKRLTTDK-ANIKDLSQILKKMPQYQKELNKYSTHLHLADDC
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE2 SRLVSERNLLEVSEVEQELACQNDH-----SSALQNIKRLLQNPKVTEFDAARLVMLYAL
. . .. .. :::.:: .: ..... : .: . : .: :...:: :
NP_001 MKHF-KGSVEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYIL
360 370 380 390 400
400 410 420 430 440 450
pF1KE2 HYERHSSNSLPGLMMDLRNKGVSEKYR---KLVSAVVEYGGKRVRGSDLFSPKDAVAITK
. : ..: :.. .. : : .: ..:.. ::. . :. . :.. . :
NP_001 LRNGVSEENLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGT--SSRLEPRERMEPTY
410 420 430 440 450 460
460 470 480 490
pF1KE2 QFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLG---PST-------------
:. .. : ...... .. :: .::.:... :..
NP_001 QL-----------SRWTPVIKDVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHW
470 480 490 500 510
500 510 520 530 540
pF1KE2 --------LRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGV-RIVLGGTTVHNTKSFLE
: :. .::.:.::... : ..:...:.: : ....:.. . . ::.
NP_001 HKNKAGIEARAGPR-LIVYVMGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLD
520 530 540 550 560 570
550 560 570
pF1KE2 EVLASGLHSRSKESSQVTSRSASRR
.. :
NP_001 DLKALDKKLEDIALP
580 590
>>NP_008880 (OMIM: 601717,613101) syntaxin-binding prote (593 aa)
initn: 212 init1: 112 opt: 319 Z-score: 380.2 bits: 80.3 E(85289): 1.9e-14
Smith-Waterman score: 460; 23.7% identity (58.2% similar) in 579 aa overlap (23-549:29-582)
10 20 30 40 50
pF1KE2 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFER
:::.::. . :.: .:.:: . . . :
NP_008 MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVED
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 IDSQNREIMKHLKAICFLRPTKENVDYIIQELR-RPKYTIY--FIYFSNVISKSDVKSLA
:... :: . :.:: .: ::...:. .:.... : .: :.:... . . :.
NP_008 INKR-REPIPSLEAIYLLSPTEKSVQALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELG
70 80 90 100 110
120 130 140 150 160
pF1KE2 EADEQEVVAEVQEFYGDYIAVNPHLFSLNI------LGCCQGRNWDPAQLSRTTQGLTAL
.. .:: ..:.. .. . ..:::. : : . :: .: ...:
NP_008 RSRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATL
120 130 140 150 160 170
170 180 190 200 210
pF1KE2 LLSLKKCPMIRYQLSSEAAKRLAECVKQVITKEYELFEFRRTEVPPL----------LLI
.:.. : :::. . : . .::. : ..: : :. ...: : :::
NP_008 CATLQEYPAIRYRKGPEDTAQLAHAV---LAK---LNAFK-ADTPSLGEGPEKTRSQLLI
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE2 LDRCDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGISKDLREVVLSAENDEFYANN
.:: : ..:::.. :.:::...:: :... .. :.:. ...:: :.:.....
NP_008 MDRAADPVSPLLHELTFQAMAYDLLDIEQDTYRY-ETTGLSEAREKAVLLDEDDDLWVEL
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE2 MYLNFAEIGSNIKNLMEDFQKKKPKEQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVV
....:...... .:.. : ..: .: .: :.. .....::..: . : :. ..
NP_008 RHMHIADVSKKVTELLRTFCESKRLTTDK-ANIKDLSQILKKMPQYQKELNKYSTHLHLA
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE2 GELSRLVSERNLLEVSEVEQELACQNDH-----SSALQNIKRLLQNPKVTEFDAARLVML
. . . .. .. :::.:: .: ..... : .: . : .: :...:
NP_008 DDCMKHF-KGSVEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLL
360 370 380 390 400
400 410 420 430 440
pF1KE2 YALHYERHSSNSLPGLMMDLRNKGVSEKYR---KLVSAVVEYGGKRVRGSDLFSPKDAVA
: : . : ..: :.. .. : : .: ..:.. ::. . :. . :.. .
NP_008 YILLRNGVSEENLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGT--SSRLEPRERME
410 420 430 440 450 460
450 460 470 480 490
pF1KE2 ITKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLG---PST----------
: :. .. : ...... .. :: .::.:... :..
NP_008 PTYQL-----------SRWTPVIKDVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARF
470 480 490 500 510
500 510 520 530 540
pF1KE2 -----------LRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGV-RIVLGGTTVHNTKS
: :. .::.:.::... : ..:...:.: : ....:.. . .
NP_008 GHWHKNKAGIEARAGPR-LIVYVMGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTR
520 530 540 550 560 570
550 560 570
pF1KE2 FLEEVLASGLHSRSKESSQVTSRSASRR
::... :
NP_008 FLDDLKALDKKLEDIALP
580 590
>>NP_001258963 (OMIM: 601717,613101) syntaxin-binding pr (604 aa)
initn: 195 init1: 112 opt: 319 Z-score: 380.1 bits: 80.3 E(85289): 2e-14
Smith-Waterman score: 429; 23.2% identity (57.1% similar) in 590 aa overlap (23-549:29-593)
10 20 30 40 50
pF1KE2 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFER
:::.::. . :.: .:.:: . . . :
NP_001 MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVED
10 20 30 40 50 60
60 70 80 90 100
pF1KE2 IDSQNREIMKHLKAICFLRPTK-----------ENVDYIIQELR-RPKYTIY--FIYFSN
:... :: . :.:: .: ::. ..:. .:.... : .: :.:..
NP_001 INKR-REPIPSLEAIYLLSPTEKAQAQRVIHLPQSVQALIKDFQGTPTFTYKAAHIFFTD
70 80 90 100 110
110 120 130 140 150
pF1KE2 VISKSDVKSLAEADEQEVVAEVQEFYGDYIAVNPHLFSLNI------LGCCQGRNWDPAQ
. . . :... .:: ..:.. .. . ..:::. : : . :
NP_001 TCPEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQ
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE2 LSRTTQGLTALLLSLKKCPMIRYQLSSEAAKRLAECVKQVITKEYELFEFRRTEVPPL--
: .: ...: .:.. : :::. . : . .::. : ..: : :. ...: :
NP_001 LEVLAQQIATLCATLQEYPAIRYRKGPEDTAQLAHAV---LAK---LNAFK-ADTPSLGE
180 190 200 210 220 230
220 230 240 250 260
pF1KE2 --------LLILDRCDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGISKDLREVVL
:::.:: : ..:::.. :.:::...:: :... .. :.:. ...::
NP_001 GPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIEQDTYRY-ETTGLSEAREKAVL
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE2 SAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPKEQQKLESIADMKAFVENYPQFKKM
:.:..... ....:...... .:.. : ..: .: .: :.. .....::..:
NP_001 LDEDDDLWVELRHMHIADVSKKVTELLRTFCESKRLTTDK-ANIKDLSQILKKMPQYQKE
300 310 320 330 340 350
330 340 350 360 370
pF1KE2 SGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDH-----SSALQNIKRLLQNPKV
. : :. .. . . . .. .. :::.:: .: ..... : .: . :
NP_001 LNKYSTHLHLADDCMKHF-KGSVEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAV
360 370 380 390 400
380 390 400 410 420 430
pF1KE2 TEFDAARLVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYR---KLVSAVVEYGGKRVRG
.: :...:: : . : ..: :.. .. : : .: ..:.. ::. .
NP_001 PAYDKIRVLLLYILLRNGVSEENLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGT--
410 420 430 440 450 460
440 450 460 470 480 490
pF1KE2 SDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLG---PS
:. . :.. . : :. .. : ...... .. :: .::.:... :.
NP_001 SSRLEPRERMEPTYQL-----------SRWTPVIKDVMEDAVEDRLDRNLWPFVSDPAPT
470 480 490 500 510
500 510 520 530
pF1KE2 T---------------------LRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGV-RIV
. : :. .::.:.::... : ..:...:.: : ...
NP_001 ASSQAAVSARFGHWHKNKAGIEARAGPR-LIVYVMGGVAMSEMRAAYEVTRATEGKWEVL
520 530 540 550 560 570
540 550 560 570
pF1KE2 LGGTTVHNTKSFLEEVLASGLHSRSKESSQVTSRSASRR
.:.. . . ::... :
NP_001 IGSSHILTPTRFLDDLKALDKKLEDIALP
580 590 600
>>NP_001027392 (OMIM: 602926,612164) syntaxin-binding pr (594 aa)
initn: 221 init1: 102 opt: 293 Z-score: 349.1 bits: 74.5 E(85289): 1e-12
Smith-Waterman score: 411; 20.1% identity (55.8% similar) in 581 aa overlap (11-545:18-580)
10 20 30 40 50
pF1KE2 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFE
. : .. .: :::..:. . ..: ...:. . . . :
NP_001 MAPIGLKAVVGEKIMHDVIKKVKKKGE-WKVLVVDQLSMRMLSSCCKMTDIMTEGITIVE
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 RIDSQNREIMKHLKAICFLRPTKENVDYIIQELRRP---KYTIYFIYFSNVISKSDVKSL
:. . :: . :.:. .. :....: .:.... : :: ..:.. . . :
NP_001 DIN-KRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNEL
60 70 80 90 100 110
120 130 140 150 160
pF1KE2 AEADEQEVVAEVQEFYGDYIAVNPHLFSLNILGCCQGRNWDP--AQ-----LSRTTQGLT
... .:. . :. .. . ...::. :. ..: :: : : .. ..
NP_001 VKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSF-YSPHKAQMKNPILERLAEQIA
120 130 140 150 160 170
170 180 190 200 210
pF1KE2 ALLLSLKKCPMIRYQLSSEAAKRLAECVKQVITKEYELFEFRRTEVPP----LLLILDRC
.: .::. : .::. . ::. ... . :. . : : ::::::
NP_001 TLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDA-YKADDPTMGEGPDKARSQLLILDRG
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE2 DDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGISKDLREVVLSAENDEFYANNMYLN
: .:.:.. :.::: ..:: :.:. . .. ::.. . :: :.:... . .
NP_001 FDPSSPVLHELTFQAMSYDLLPIEND-VYKYETSGIGEARVKEVLLDEDDDLWIALRHKH
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE2 FAEIGSNIKNLMEDFQKKKPKEQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELS
.::..... ..::...: . . .. :.. .....::..: . : :. .. .
NP_001 IAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCM
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE2 RLVSERNLLEVSEVEQELACQNDH-----SSALQNIKRLLQNPKVTEFDAARLVMLYALH
. . .. .. .:::.:: .: .. .. : .: . .:. .: :...:: .
NP_001 KHY-QGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFL
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE2 YERHSSNSLPGLMMDLRNKGVSEKYRKLVSAVVEYGGKRVRGSDLF---SPKDAVAITKQ
. . ..: :. .. . . .... ... : : : : .:. :..:
NP_001 KNGITEENLNKLI---QHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQ
420 430 440 450 460 470
460 470 480 490
pF1KE2 FLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLG--------------------
. .. :.... .. :. .: . :::..
NP_001 TYQ--------LSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWH
480 490 500 510 520
500 510 520 530 540
pF1KE2 ----PSTLRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKSFLEEV
:. :. :. .:.:..::.. .: .:...... ....:.: . . ...:.
NP_001 KNKAPGEYRSGPR-LIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTL
530 540 550 560 570 580
550 560 570
pF1KE2 LASGLHSRSKESSQVTSRSASRR
NP_001 KKLNKTDEEISS
590
>>NP_003156 (OMIM: 602926,612164) syntaxin-binding prote (603 aa)
initn: 221 init1: 102 opt: 293 Z-score: 349.0 bits: 74.5 E(85289): 1.1e-12
Smith-Waterman score: 424; 20.5% identity (55.6% similar) in 599 aa overlap (11-563:18-594)
10 20 30 40 50
pF1KE2 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFE
. : .. .: :::..:. . ..: ...:. . . . :
NP_003 MAPIGLKAVVGEKIMHDVIKKVKKKGE-WKVLVVDQLSMRMLSSCCKMTDIMTEGITIVE
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 RIDSQNREIMKHLKAICFLRPTKENVDYIIQELRRP---KYTIYFIYFSNVISKSDVKSL
:... :: . :.:. .. :....: .:.... : :: ..:.. . . :
NP_003 DINKR-REPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNEL
60 70 80 90 100 110
120 130 140 150 160
pF1KE2 AEADEQEVVAEVQEFYGDYIAVNPHLFSLNILGCCQGRNWDP--AQ-----LSRTTQGLT
... .:. . :. .. . ...::. :. ..: :: : : .. ..
NP_003 VKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSF-YSPHKAQMKNPILERLAEQIA
120 130 140 150 160 170
170 180 190 200 210
pF1KE2 ALLLSLKKCPMIRYQLSSEAAKRLAECVKQVITKEYELFEFRRTEVPP----LLLILDRC
.: .::. : .::. . ::. ... . :. . : : ::::::
NP_003 TLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDA-YKADDPTMGEGPDKARSQLLILDRG
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE2 DDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGISKDLREVVLSAENDEFYANNMYLN
: .:.:.. :.::: ..:: :.:. . .. ::.. . :: :.:... . .
NP_003 FDPSSPVLHELTFQAMSYDLLPIEND-VYKYETSGIGEARVKEVLLDEDDDLWIALRHKH
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE2 FAEIGSNIKNLMEDFQKKKPKEQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELS
.::..... ..::...: . . .. :.. .....::..: . : :. .. .
NP_003 IAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCM
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE2 RLVSERNLLEVSEVEQELACQNDH-----SSALQNIKRLLQNPKVTEFDAARLVMLYALH
. . .. .. .:::.:: .: .. .. : .: . .:. .: :...:: .
NP_003 KHY-QGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFL
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE2 YERHSSNSLPGLMMDLRNKGVSEKYRKLVSAVVEYGGKRVRGSDLF---SPKDAVAITKQ
. . ..: :. .. . . .... ... : : : : .:. :..:
NP_003 KNGITEENLNKLI---QHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQ
420 430 440 450 460 470
460 470 480 490
pF1KE2 FLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLG--------------------
. .. :.... .. :. .: . :::..
NP_003 TYQ--------LSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWH
480 490 500 510 520
500 510 520 530 540
pF1KE2 ----PSTLRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKSFLEEV
:. :. :. .:.:..::.. .: .:...... ....:.: . . .:: ..
NP_003 KNKAPGEYRSGPR-LIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPTKFLMDL
530 540 550 560 570 580
550 560 570
pF1KE2 LASGLHSRSKESSQVTSRSASRR
: .:::.:.
NP_003 R----HPDFRESSRVSFEDQAPTME
590 600
570 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 16:28:15 2016 done: Tue Nov 8 16:28:17 2016
Total Scan time: 7.770 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]