Result of FASTA (omim) for
pF1KE2586
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2586, 791 aa
1>>>pF1KE2586 791 - 791 aa - 791 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.1406+/-0.000431; mu= 6.6918+/- 0.027
mean_var=127.8694+/-26.097, 0's: 0 Z-trim(114.6): 51 B-trim: 8 in 1/52
Lambda= 0.113420
statistics sampled from 24527 (24576) to 24527 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.633), E-opt: 0.2 (0.288), width: 16
Scan time: 9.690
The best scores are: opt bits E(85289)
NP_443166 (OMIM: 608481) solute carrier family 26 ( 791) 5179 859.3 0
NP_599152 (OMIM: 608481) solute carrier family 26 ( 887) 5179 859.4 0
XP_011507423 (OMIM: 608481) PREDICTED: solute carr ( 702) 4588 762.6 0
XP_011507424 (OMIM: 608481) PREDICTED: solute carr ( 627) 4104 683.4 7.9e-196
XP_011507426 (OMIM: 608481) PREDICTED: solute carr ( 466) 3018 505.7 1.9e-142
NP_001035544 (OMIM: 610068) solute carrier family ( 738) 1724 294.0 1.6e-78
NP_075062 (OMIM: 610068) solute carrier family 26 ( 759) 1724 294.0 1.6e-78
NP_599025 (OMIM: 610068) solute carrier family 26 ( 758) 1722 293.7 2e-78
NP_602298 (OMIM: 610068) solute carrier family 26 ( 740) 1535 263.1 3.2e-69
NP_996766 (OMIM: 604943,613865) prestin isoform b ( 685) 1484 254.7 9.8e-67
XP_011514472 (OMIM: 604943,613865) PREDICTED: pres ( 744) 1484 254.7 1.1e-66
NP_945350 (OMIM: 604943,613865) prestin isoform a ( 744) 1484 254.7 1.1e-66
XP_005250482 (OMIM: 274600,600791,605646) PREDICTE ( 780) 1430 245.9 5e-64
NP_000432 (OMIM: 274600,600791,605646) pendrin [Ho ( 780) 1430 245.9 5e-64
XP_011514169 (OMIM: 126650,214700) PREDICTED: chlo ( 764) 1393 239.8 3.3e-62
NP_000102 (OMIM: 126650,214700) chloride anion exc ( 764) 1393 239.8 3.3e-62
NP_996767 (OMIM: 604943,613865) prestin isoform c ( 516) 1320 227.8 9e-59
NP_001308716 (OMIM: 604943,613865) prestin isoform ( 653) 1123 195.6 5.6e-49
NP_001161434 (OMIM: 604943,613865) prestin isoform ( 712) 1123 195.6 6.1e-49
NP_001268662 (OMIM: 610068) solute carrier family ( 651) 1090 190.2 2.4e-47
NP_001268661 (OMIM: 610068) solute carrier family ( 723) 1082 188.9 6.5e-47
XP_016867807 (OMIM: 274600,600791,605646) PREDICTE ( 754) 1034 181.1 1.6e-44
XP_006716088 (OMIM: 274600,600791,605646) PREDICTE ( 423) 1029 180.2 1.6e-44
XP_016865724 (OMIM: 606766,608480) PREDICTED: test ( 970) 983 172.8 6.4e-42
NP_001180405 (OMIM: 606766,608480) testis anion tr ( 970) 983 172.8 6.4e-42
NP_443193 (OMIM: 606766,608480) testis anion trans ( 970) 983 172.8 6.4e-42
NP_439897 (OMIM: 608479) anion exchange transporte ( 656) 946 166.7 3e-40
NP_001269285 (OMIM: 608479) anion exchange transpo ( 656) 946 166.7 3e-40
NP_599028 (OMIM: 608479) anion exchange transporte ( 663) 946 166.7 3e-40
NP_000103 (OMIM: 222600,226900,256050,600972,60671 ( 739) 881 156.1 5.3e-37
XP_016864680 (OMIM: 222600,226900,256050,600972,60 ( 739) 881 156.1 5.3e-37
NP_996768 (OMIM: 604943,613865) prestin isoform d ( 335) 828 147.3 1e-34
NP_071325 (OMIM: 167030,610130) sulfate anion tran ( 701) 783 140.0 3.4e-32
NP_998778 (OMIM: 167030,610130) sulfate anion tran ( 701) 783 140.0 3.4e-32
NP_619732 (OMIM: 606766,608480) testis anion trans ( 865) 520 97.0 3.7e-19
NP_001269286 (OMIM: 608479) anion exchange transpo ( 355) 365 71.5 7e-12
NP_001159820 (OMIM: 610117) sodium-independent sul ( 606) 340 67.5 2e-10
NP_775897 (OMIM: 610117) sodium-independent sulfat ( 606) 340 67.5 2e-10
NP_001159819 (OMIM: 610117) sodium-independent sul ( 606) 340 67.5 2e-10
NP_001159821 (OMIM: 610117) sodium-independent sul ( 606) 340 67.5 2e-10
XP_016879996 (OMIM: 610117) PREDICTED: sodium-inde ( 630) 276 57.0 2.9e-07
XP_006721896 (OMIM: 610117) PREDICTED: sodium-inde ( 630) 276 57.0 2.9e-07
XP_016879995 (OMIM: 610117) PREDICTED: sodium-inde ( 677) 276 57.0 3.1e-07
XP_016879994 (OMIM: 610117) PREDICTED: sodium-inde ( 696) 276 57.0 3.2e-07
NP_602297 (OMIM: 167030,610130) sulfate anion tran ( 224) 265 55.1 3.9e-07
XP_011512596 (OMIM: 606766,608480) PREDICTED: test ( 944) 232 49.9 6.1e-05
XP_011522955 (OMIM: 610117) PREDICTED: sodium-inde ( 441) 212 46.5 0.00029
XP_011522956 (OMIM: 610117) PREDICTED: sodium-inde ( 441) 212 46.5 0.00029
XP_011522954 (OMIM: 610117) PREDICTED: sodium-inde ( 465) 212 46.5 0.00031
>>NP_443166 (OMIM: 608481) solute carrier family 26 memb (791 aa)
initn: 5179 init1: 5179 opt: 5179 Z-score: 4585.7 bits: 859.3 E(85289): 0
Smith-Waterman score: 5179; 99.9% identity (100.0% similar) in 791 aa overlap (1-791:1-791)
10 20 30 40 50 60
pF1KE2 MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 WLPNYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGV
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 WLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 HQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 HQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 AIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 FIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 CKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 CKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 YDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 YDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITML
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 VLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 VLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 GVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 GVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 ANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 ANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 DFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 DFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 TFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 LECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFG
730 740 750 760 770 780
790
pF1KE2 SMFHAETLTAL
:::::::::::
NP_443 SMFHAETLTAL
790
>>NP_599152 (OMIM: 608481) solute carrier family 26 memb (887 aa)
initn: 5179 init1: 5179 opt: 5179 Z-score: 4584.9 bits: 859.4 E(85289): 0
Smith-Waterman score: 5179; 99.9% identity (100.0% similar) in 791 aa overlap (1-791:1-791)
10 20 30 40 50 60
pF1KE2 MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 WLPNYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGV
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 WLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 HQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 HQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 AIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 FIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 CKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 CKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 YDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 YDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITML
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 VLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 VLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 GVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 GVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 ANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 ANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 DFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 DFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 TFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 LECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 LECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFG
730 740 750 760 770 780
790
pF1KE2 SMFHAETLTAL
:::::::::::
NP_599 SMFHAETLTALESLSAAGGCYPYRSESLVSPLFTRQALAAMDKPPAHSTPPTSALSLAAE
790 800 810 820 830 840
>>XP_011507423 (OMIM: 608481) PREDICTED: solute carrier (702 aa)
initn: 4588 init1: 4588 opt: 4588 Z-score: 4063.9 bits: 762.6 E(85289): 0
Smith-Waterman score: 4588; 100.0% identity (100.0% similar) in 702 aa overlap (90-791:1-702)
60 70 80 90 100 110
pF1KE2 SWLPNYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGG
::::::::::::::::::::::::::::::
XP_011 MAFALLANLPAVNGLYSSFFPLLTYFFLGG
10 20 30
120 130 140 150 160 170
pF1KE2 VHQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACL
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE2 TAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVF
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE2 TFIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISG
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE2 GCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKH
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE2 GYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITM
280 290 300 310 320 330
420 430 440 450 460 470
pF1KE2 LVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLP
340 350 360 370 380 390
480 490 500 510 520 530
pF1KE2 YGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLY
400 410 420 430 440 450
540 550 560 570 580 590
pF1KE2 FANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQ
460 470 480 490 500 510
600 610 620 630 640 650
pF1KE2 QDFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPF
520 530 540 550 560 570
660 670 680 690 700 710
pF1KE2 VTFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDG
580 590 600 610 620 630
720 730 740 750 760 770
pF1KE2 SLECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMF
640 650 660 670 680 690
780 790
pF1KE2 GSMFHAETLTAL
::::::::::::
XP_011 GSMFHAETLTAL
700
>>XP_011507424 (OMIM: 608481) PREDICTED: solute carrier (627 aa)
initn: 4104 init1: 4104 opt: 4104 Z-score: 3636.7 bits: 683.4 E(85289): 7.9e-196
Smith-Waterman score: 4104; 100.0% identity (100.0% similar) in 627 aa overlap (165-791:1-627)
140 150 160 170 180 190
pF1KE2 VGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLTAIIQMGLGFMQFGF
::::::::::::::::::::::::::::::
XP_011 MEAERLHVSATLACLTAIIQMGLGFMQFGF
10 20 30
200 210 220 230 240 250
pF1KE2 VAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIA
40 50 60 70 80 90
260 270 280 290 300 310
pF1KE2 SLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGE
100 110 120 130 140 150
320 330 340 350 360 370
pF1KE2 IQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGC
160 170 180 190 200 210
380 390 400 410 420 430
pF1KE2 SNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVL
220 230 240 250 260 270
440 450 460 470 480 490
pF1KE2 GALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVV
280 290 300 310 320 330
500 510 520 530 540 550
pF1KE2 FQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKT
340 350 360 370 380 390
560 570 580 590 600 610
pF1KE2 GMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQ
400 410 420 430 440 450
620 630 640 650 660 670
pF1KE2 TPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSF
460 470 480 490 500 510
680 690 700 710 720 730
pF1KE2 VDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAV
520 530 540 550 560 570
740 750 760 770 780 790
pF1KE2 LFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFGSMFHAETLTAL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFGSMFHAETLTAL
580 590 600 610 620
>>XP_011507426 (OMIM: 608481) PREDICTED: solute carrier (466 aa)
initn: 3017 init1: 3017 opt: 3018 Z-score: 2678.5 bits: 505.7 E(85289): 1.9e-142
Smith-Waterman score: 3018; 99.6% identity (99.8% similar) in 465 aa overlap (1-464:1-465)
10 20 30 40 50 60
pF1KE2 MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 WLPNYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGV
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 HQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 CKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 YDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITML
370 380 390 400 410 420
430 440 450 460 470
pF1KE2 VLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDC-CIWVVSFLSSFFLSLP
::::::::::::::::::::::::::::::::::::::::::: :
XP_011 VLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCVCF
430 440 450 460
480 490 500 510 520 530
pF1KE2 YGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLY
>>NP_001035544 (OMIM: 610068) solute carrier family 26 m (738 aa)
initn: 1316 init1: 1178 opt: 1724 Z-score: 1530.8 bits: 294.0 E(85289): 1.6e-78
Smith-Waterman score: 1724; 37.2% identity (73.1% similar) in 713 aa overlap (32-744:30-728)
10 20 30 40 50 60
pF1KE2 SQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLSW
: .. :. ..:: :. :... :::: :
NP_001 MDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVW
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 LPNYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVH
:: : ..:... :::.::: . .:.:::.:.::::.:: : ::::::.:.. ::..: .
NP_001 LPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSR
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 QMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLTA
.. :::::.:..::.. .:::. : :.:... .: .: :..:..::. :..
NP_001 HISVGTFAVMSVMVGSVTESLAPQ--------ALNDSMINETARDAARVQVASTLSVLVG
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 IIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTF
..:.:::...::::. :::: ..::. :::..:...: :::.::: . :..:: :...:
NP_001 LFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTV
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 IDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGC
...: .::........ : ..:. ::.:: :: . .... .::: :..... ::.:: :
NP_001 LEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGM
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 KMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGY
. .......::.: :. ::.: .. .. ..:.::..:.:...: ...:. .: .:::
NP_001 GLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGY
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 DVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLV
::::::..::: ::..:..:. . :..: .:. ...::.::::. :: ... ..
NP_001 RVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVK
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 LGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYG
:: .. :::.::.:.: ::::. :.::.: ::. .. : ::.:.: ....:.: :
NP_001 LGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLG
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 VAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFA
..:.: ::.:.:: .::. . .:.:: ::::: . :..:....:.:.. . .:::
NP_001 LVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFA
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE2 NSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQD
:.:.. . . . :.: . .. :.: :::::. ... :....: .. . . .. .
NP_001 NAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSIN
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE2 FENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVT
... .:: . .:: : :. : .. ...:: . : . : :
NP_001 VNTSLEDMRSNNVEDCKMMQVS----SGDKMEDATANGQEDSKAP-DGSTLKALGLPQPD
600 610 620 630 640
670 680 690 700 710 720
pF1KE2 FHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSL
::.::::....:::: . .:.: .. . .: :.:... :. : ... : : :.:.
NP_001 FHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFF-DASI
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE2 ECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFGS
::.: :.:::: :: . : :
NP_001 TKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
710 720 730
>>NP_075062 (OMIM: 610068) solute carrier family 26 memb (759 aa)
initn: 1316 init1: 1178 opt: 1724 Z-score: 1530.6 bits: 294.0 E(85289): 1.6e-78
Smith-Waterman score: 1724; 37.2% identity (73.1% similar) in 713 aa overlap (32-744:51-749)
10 20 30 40 50 60
pF1KE2 SQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLSW
: .. :. ..:: :. :... :::: :
NP_075 AMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVW
30 40 50 60 70 80
70 80 90 100 110 120
pF1KE2 LPNYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVH
:: : ..:... :::.::: . .:.:::.:.::::.:: : ::::::.:.. ::..: .
NP_075 LPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSR
90 100 110 120 130 140
130 140 150 160 170 180
pF1KE2 QMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLTA
.. :::::.:..::.. .:::. : :.:... .: .: :..:..::. :..
NP_075 HISVGTFAVMSVMVGSVTESLAPQ--------ALNDSMINETARDAARVQVASTLSVLVG
150 160 170 180 190
190 200 210 220 230 240
pF1KE2 IIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTF
..:.:::...::::. :::: ..::. :::..:...: :::.::: . :..:: :...:
NP_075 LFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTV
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE2 IDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGC
...: .::........ : ..:. ::.:: :: . .... .::: :..... ::.:: :
NP_075 LEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGM
260 270 280 290 300 310
310 320 330 340 350 360
pF1KE2 KMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGY
. .......::.: :. ::.: .. .. ..:.::..:.:...: ...:. .: .:::
NP_075 GLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGY
320 330 340 350 360 370
370 380 390 400 410 420
pF1KE2 DVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLV
::::::..::: ::..:..:. . :..: .:. ...::.::::. :: ... ..
NP_075 RVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVK
380 390 400 410 420 430
430 440 450 460 470 480
pF1KE2 LGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYG
:: .. :::.::.:.: ::::. :.::.: ::. .. : ::.:.: ....:.: :
NP_075 LGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLG
440 450 460 470 480 490
490 500 510 520 530 540
pF1KE2 VAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFA
..:.: ::.:.:: .::. . .:.:: ::::: . :..:....:.:.. . .:::
NP_075 LVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFA
500 510 520 530 540 550
550 560 570 580 590 600
pF1KE2 NSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQD
:.:.. . . . :.: . .. :.: :::::. ... :....: .. . . .. .
NP_075 NAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSIN
560 570 580 590 600 610
610 620 630 640 650 660
pF1KE2 FENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVT
... .:: . .:: : :. : .. ...:: . : . : :
NP_075 VNTSLEDMRSNNVEDCKMMQVS----SGDKMEDATANGQEDSKAP-DGSTLKALGLPQPD
620 630 640 650 660
670 680 690 700 710 720
pF1KE2 FHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSL
::.::::....:::: . .:.: .. . .: :.:... :. : ... : : :.:.
NP_075 FHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFF-DASI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 ECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFGS
::.: :.:::: :: . : :
NP_075 TKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
730 740 750
>>NP_599025 (OMIM: 610068) solute carrier family 26 memb (758 aa)
initn: 1316 init1: 1178 opt: 1722 Z-score: 1528.9 bits: 293.7 E(85289): 2e-78
Smith-Waterman score: 1722; 37.2% identity (73.2% similar) in 713 aa overlap (32-744:51-748)
10 20 30 40 50 60
pF1KE2 SQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLSW
: .. :. ..:: :. :... :::: :
NP_599 AMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVW
30 40 50 60 70 80
70 80 90 100 110 120
pF1KE2 LPNYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVH
:: : ..:... :::.::: . .:.:::.:.::::.:: : ::::::.:.. ::..: .
NP_599 LPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSR
90 100 110 120 130 140
130 140 150 160 170 180
pF1KE2 QMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLTA
.. :::::.:..::.. .:::. : :.:... .: .: :..:..::. :..
NP_599 HISVGTFAVMSVMVGSVTESLAPQ--------ALNDSMINETARDAARVQVASTLSVLVG
150 160 170 180 190
190 200 210 220 230 240
pF1KE2 IIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTF
..:.:::...::::. :::: ..::. :::..:...: :::.::: . :..:: :...:
NP_599 LFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTV
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE2 IDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGC
...: .::........ : ..:. ::.:: :: . .... .::: :..... ::.:: :
NP_599 LEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGM
260 270 280 290 300 310
310 320 330 340 350 360
pF1KE2 KMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGY
. .......::.: :. ::.: .. .. ..:.::..:.:...: ...:. .: .:::
NP_599 GLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGY
320 330 340 350 360 370
370 380 390 400 410 420
pF1KE2 DVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLV
::::::..::: ::..:..:. . :..: .:. ...::.::::. :: ... ..
NP_599 RVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVK
380 390 400 410 420 430
430 440 450 460 470 480
pF1KE2 LGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYG
:: .. :::.::.:.: ::::. :.::.: ::. .. : ::.:.: ....:.: :
NP_599 LGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLG
440 450 460 470 480 490
490 500 510 520 530 540
pF1KE2 VAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFA
..:.: ::.:.:: .::. . .:.:: ::::: . :..:....:.:.. . .:::
NP_599 LVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFA
500 510 520 530 540 550
550 560 570 580 590 600
pF1KE2 NSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQD
:.:.. . . . :.: . .. :.: :::::. ... :....: .. . . .. .
NP_599 NAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSIN
560 570 580 590 600 610
610 620 630 640 650 660
pF1KE2 FENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVT
:. : .: : . .... : :. : .. ...:: . : . : :
NP_599 V-NTSLEDMRSN----NVEDCKMMVSSGDKMEDATANGQEDSKAP-DGSTLKALGLPQPD
620 630 640 650 660
670 680 690 700 710 720
pF1KE2 FHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSL
::.::::....:::: . .:.: .. . .: :.:... :. : ... : : :.:.
NP_599 FHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFF-DASI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 ECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFGS
::.: :.:::: :: . : :
NP_599 TKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
730 740 750
>>NP_602298 (OMIM: 610068) solute carrier family 26 memb (740 aa)
initn: 1706 init1: 1178 opt: 1535 Z-score: 1363.7 bits: 263.1 E(85289): 3.2e-69
Smith-Waterman score: 1697; 37.4% identity (72.4% similar) in 713 aa overlap (32-744:51-730)
10 20 30 40 50 60
pF1KE2 SQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLSW
: .. :. ..:: :. :... :::: :
NP_602 AMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVW
30 40 50 60 70 80
70 80 90 100 110 120
pF1KE2 LPNYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVH
:: : ..:... :::.::: . .:.:::.:.::::.:: : ::::::.:.. ::..: .
NP_602 LPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSR
90 100 110 120 130 140
130 140 150 160 170 180
pF1KE2 QMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLTA
.. :::::.:..::.. .:::. : :.:... .: .: :..:..::. :..
NP_602 HISVGTFAVMSVMVGSVTESLAPQ--------ALNDSMINETARDAARVQVASTLSVLVG
150 160 170 180 190
190 200 210 220 230 240
pF1KE2 IIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTF
..:.:::...::::. :::: ..::. :::..:...: :::.::: . :..:: :...:
NP_602 LFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTV
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE2 IDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGC
...: .::........ : ..:. ::.:: :: . .... .::: :..... ::.:: :
NP_602 LEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGM
260 270 280 290 300 310
310 320 330 340 350 360
pF1KE2 KMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGY
. .......::.: :. ::.: .. .. ..:.::..:.:...: ...:. .: .:::
NP_602 GLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGY
320 330 340 350 360 370
370 380 390 400 410 420
pF1KE2 DVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLV
::::::..::: ::..:..:. . :..: .:. ...::.::::. :: ... ..
NP_602 RVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVK
380 390 400 410 420 430
430 440 450 460 470 480
pF1KE2 LGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYG
:: .. :::.::.:.: ::::. :.::.: ::. .. : ::.:.: ....:.: :
NP_602 LGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLG
440 450 460 470 480 490
490 500 510 520 530 540
pF1KE2 VAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFA
..:.: ::.:.:: .::. . .:.:: ::::: . :..:....:.:.. . .:::
NP_602 LVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFA
500 510 520 530 540 550
550 560 570 580 590 600
pF1KE2 NSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQD
:.:.. . . . :.: . .. :.: :::::. ... :....: .. . :
NP_602 NAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAGPLLSACLAP-
560 570 580 590 600 610
610 620 630 640 650 660
pF1KE2 FENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVT
... : .. : ::: . ::..: : . .: : :. :
NP_602 -QQVSSGDKMEDAT-ANG--------QEDSKAPDGS----TLKALGLPQ------P---D
620 630 640
670 680 690 700 710 720
pF1KE2 FHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSL
::.::::....:::: . .:.: .. . .: :.:... :. : ... : : :.:.
NP_602 FHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFF-DASI
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE2 ECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFGS
::.: :.:::: :: . : :
NP_602 TKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
710 720 730 740
>>NP_996766 (OMIM: 604943,613865) prestin isoform b [Hom (685 aa)
initn: 1548 init1: 1027 opt: 1484 Z-score: 1319.1 bits: 254.7 E(85289): 9.8e-67
Smith-Waterman score: 1584; 36.3% identity (71.9% similar) in 700 aa overlap (7-704:15-681)
10 20 30 40 50
pF1KE2 MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYP--VGEKLRNAFRCSSAKIKA
:: :.: .: ....... ::.. : ...::..:: :. ::.
NP_996 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKV-PDSIADKLKQAFTCTPKKIRN
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 VVFGLLPVLSWLPNYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFP
... .::. .::: ::.:.:.. ::..:.: : .:.:::.:::.:: .: . ::::::.:
NP_996 IIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 LLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERL
.. : ::: ... : :::::...:.. ..:.:.. :. ...: . : : .: :.
NP_996 VIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDI--VIPGGVNATN-GTEARDALRV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 HVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPS
.:. ... :..:::. :: .::::::::.: ..::: :::..... :.:::.::.
NP_996 KVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKR
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 YTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIV
:.: :.:.. . . .:. . :. :: .:. ..:. ::.: :. .:. ::: :...
NP_996 YSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 VVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLA
::..:.::.: .. ..:....:: . :. :..: .: .. . :...:::.. ....
NP_996 VVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTIS
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE2 MGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLC
:..::::::::.::.:::.:::: : .::.:. : :.:: .:. .:.:::.:.:.
NP_996 MAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCL
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE2 VSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSF
.::......:. :. . ::..::.:.. ::::. . :..: ..:: ::.. ::...:
NP_996 ASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTF
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE2 LSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIK
.::.::.: ::. ..: ...:.:...:: . .:... .::.:.. .:.....: :::
NP_996 VSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIK
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE2 IITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKT
:. .:.:.:::... . . :::..: .. :..: ..: :. . : .
NP_996 IFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNAN-------MAN
540 550 560 570 580
600 610 620 630 640 650
pF1KE2 KTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPS
:: . . : :.: : :... .: :.: :: .. :
NP_996 ATVVKADAEVDGEDA--TKPEEE----DGE-VKY--------------PPIVIKST-FPE
590 600 610 620
660 670 680 690 700 710
pF1KE2 DMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDI
.: .:: . ::.:::.. :.:.: .:.:.:: . . :: .:. :.:.. :
NP_996 EMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAFIQR
630 640 650 660 670 680
720 730 740 750 760 770
pF1KE2 SHGGVFEDGSLECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRS
791 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 16:34:40 2016 done: Tue Nov 8 16:34:42 2016
Total Scan time: 9.690 Total Display time: 0.190
Function used was FASTA [36.3.4 Apr, 2011]