FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2603, 979 aa 1>>>pF1KE2603 979 - 979 aa - 979 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.8104+/-0.00121; mu= -8.5194+/- 0.073 mean_var=315.1759+/-64.410, 0's: 0 Z-trim(111.2): 71 B-trim: 0 in 0/51 Lambda= 0.072243 statistics sampled from 12145 (12194) to 12145 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.375), width: 16 Scan time: 3.270 The best scores are: opt bits E(32554) CCDS46818.1 MAP4 gene_id:4134|Hs108|chr3 (1135) 3736 403.9 9.1e-112 CCDS33750.1 MAP4 gene_id:4134|Hs108|chr3 (1152) 3736 404.0 9.2e-112 CCDS46821.1 MAP4 gene_id:4134|Hs108|chr3 ( 99) 622 78.9 5.7e-15 CCDS11501.1 MAPT gene_id:4137|Hs108|chr17 ( 758) 607 77.7 9.6e-14 CCDS45715.1 MAPT gene_id:4137|Hs108|chr17 ( 776) 582 75.1 5.9e-13 CCDS33369.1 MAP2 gene_id:4133|Hs108|chr2 ( 559) 575 74.3 7.4e-13 CCDS11499.1 MAPT gene_id:4137|Hs108|chr17 ( 441) 570 73.8 8.7e-13 CCDS45716.1 MAPT gene_id:4137|Hs108|chr17 ( 412) 555 72.2 2.4e-12 CCDS11500.1 MAPT gene_id:4137|Hs108|chr17 ( 383) 543 70.9 5.4e-12 >>CCDS46818.1 MAP4 gene_id:4134|Hs108|chr3 (1135 aa) initn: 5863 init1: 3590 opt: 3736 Z-score: 2120.1 bits: 403.9 E(32554): 9.1e-112 Smith-Waterman score: 4991; 82.9% identity (82.9% similar) in 1011 aa overlap (1-838:1-1011) 10 20 30 40 50 60 pF1KE2 MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 ESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 EDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 EDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 CNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 CNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 IMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 ALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 KMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 ANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 ANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 LPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEM 490 500 510 520 530 540 550 pF1KE2 EVALTEDQVPALKTEAP------------------------------------------- ::::::::::::::::: CCDS46 EVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKG 550 560 570 580 590 600 pF1KE2 ------------------------------------------------------------ CCDS46 ISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSE 610 620 630 640 650 660 pF1KE2 ------------------------------------------------------------ CCDS46 LSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQ 670 680 690 700 710 720 560 570 580 590 600 pF1KE2 ----------TTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAK :::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 PTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAK 730 740 750 760 770 780 610 620 630 640 650 660 pF1KE2 APEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 APEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTE 790 800 810 820 830 840 670 680 690 700 710 720 pF1KE2 GKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 GKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPST 850 860 870 880 890 900 730 740 750 760 770 780 pF1KE2 TPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 TPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKT 910 920 930 940 950 960 790 800 810 820 830 840 pF1KE2 EAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGG ::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 EAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGG 970 980 990 1000 1010 1020 850 860 870 880 890 900 pF1KE2 GNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHL CCDS46 GNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHL 1030 1040 1050 1060 1070 1080 >>CCDS33750.1 MAP4 gene_id:4134|Hs108|chr3 (1152 aa) initn: 3590 init1: 3590 opt: 3736 Z-score: 2120.0 bits: 404.0 E(32554): 9.2e-112 Smith-Waterman score: 4991; 82.9% identity (82.9% similar) in 1011 aa overlap (1-838:1-1011) 10 20 30 40 50 60 pF1KE2 MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 ESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 EDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 EDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 CNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 CNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 IMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 ALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 KMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 ANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 ANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 LPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEM 490 500 510 520 530 540 550 pF1KE2 EVALTEDQVPALKTEAP------------------------------------------- ::::::::::::::::: CCDS33 EVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKG 550 560 570 580 590 600 pF1KE2 ------------------------------------------------------------ CCDS33 ISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSE 610 620 630 640 650 660 pF1KE2 ------------------------------------------------------------ CCDS33 LSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQ 670 680 690 700 710 720 560 570 580 590 600 pF1KE2 ----------TTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAK :::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 PTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAK 730 740 750 760 770 780 610 620 630 640 650 660 pF1KE2 APEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 APEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTE 790 800 810 820 830 840 670 680 690 700 710 720 pF1KE2 GKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 GKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPST 850 860 870 880 890 900 730 740 750 760 770 780 pF1KE2 TPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 TPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKT 910 920 930 940 950 960 790 800 810 820 830 840 pF1KE2 EAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGG ::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 EAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGG 970 980 990 1000 1010 1020 850 860 870 880 890 900 pF1KE2 GNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHL CCDS33 GNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHL 1030 1040 1050 1060 1070 1080 >-- initn: 939 init1: 939 opt: 939 Z-score: 544.5 bits: 112.4 E(32554): 5.2e-24 Smith-Waterman score: 939; 100.0% identity (100.0% similar) in 141 aa overlap (839-979:1012-1152) 810 820 830 840 850 860 pF1KE2 ASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGS :::::::::::::::::::::::::::::: CCDS33 ASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGS 990 1000 1010 1020 1030 1040 870 880 890 900 910 920 pF1KE2 KANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 KANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGP 1050 1060 1070 1080 1090 1100 930 940 950 960 970 pF1KE2 PAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI ::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 PAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI 1110 1120 1130 1140 1150 >>CCDS46821.1 MAP4 gene_id:4134|Hs108|chr3 (99 aa) initn: 622 init1: 622 opt: 622 Z-score: 382.2 bits: 78.9 E(32554): 5.7e-15 Smith-Waterman score: 622; 100.0% identity (100.0% similar) in 97 aa overlap (1-97:1-97) 10 20 30 40 50 60 pF1KE2 MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWP ::::::::::::::::::::::::::::::::::::: CCDS46 ESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTEA 70 80 90 130 140 150 160 170 180 pF1KE2 EDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSP >>CCDS11501.1 MAPT gene_id:4137|Hs108|chr17 (758 aa) initn: 477 init1: 477 opt: 607 Z-score: 360.3 bits: 77.7 E(32554): 9.6e-14 Smith-Waterman score: 673; 31.5% identity (54.1% similar) in 604 aa overlap (337-916:163-689) 310 320 330 340 350 360 pF1KE2 ELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASP--IKMDL : :. :. : : .: .: .: CCDS11 QEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQL 140 150 160 170 180 190 370 380 390 400 410 pF1KE2 APS-KDMGPPKENKKETER-ASPIKMDLAPSKDMGPPKEN---KIVPAKDLVLLSEIEVA . .. ::: .. :: .: ..: . : . :... : ::.: .: CCDS11 LGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDG--RPPQTAA 200 210 220 230 240 250 420 430 440 450 460 470 pF1KE2 QANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLE----AEVAPV . : . .: . .. ..:. . : .: .: . ::: .:..: CCDS11 REATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPN 260 270 280 290 300 310 480 490 500 510 520 530 pF1KE2 --KDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLI-- :..:. : : ::. :. . : .:. : :. : : . . CCDS11 VQKEQAHSEEHLGRAAFPGAPGEGPEA---RGPSLGEDTKEA---DLPEPSEKQPAAAPR 320 330 340 350 360 540 550 560 570 580 pF1KE2 -KNVCLPPEME---VALTEDQVPALKTEAPTTIGGLNKKPMSLASGLVPAAPPKRPAVAS : : :... :. ..: . . .: :. . : .: . : ::.:. .: CCDS11 GKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAK---TLKNR--PCLSPKHPTPGS 370 380 390 400 410 590 600 610 620 630 640 pF1KE2 ARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTG . : : :: .: : :: .:: : .:. .::.::.... . . . . . CCDS11 SDPLIQPS---SP-----AVCPEPPSSP-KYVSSVTSRTGSSGAKEMKLKGADGKTKIAT 420 430 440 450 460 470 650 660 670 680 690 700 pF1KE2 PSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSG-TA : . .: : . .:. :.. .. ::. :: . : :.. :. :: .. CCDS11 PRGAAP----PGQ------KGQ-ANATRIPAKTPPAPKTPP---SSGEPPKSGDRSGYSS 480 490 500 510 710 720 730 740 750 760 pF1KE2 PAAGVVP-SRVKATPMPSRPSTTPFIDKKPTSAK--PSSTTPRLSRLATN-TSAPDLKNV :.. .: :: .. .:. :. : :: . .. :.: . ::: : . :::::: CCDS11 PGSPGTPGSRSRTPSLPTPPTREP---KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNV 520 530 540 550 560 570 770 780 790 800 810 820 pF1KE2 RSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIV .::.:::::.::::::: ::::. CCDS11 KSKIGSTENLKHQPGGG--------------------------------------KVQII 580 590 830 840 850 860 870 880 pF1KE2 SKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVK .::.. :..:::::::::::::::::.::: : ::.:::.::::: .::.::::::.:. CCDS11 NKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVE 600 610 620 630 640 650 890 900 910 920 930 940 pF1KE2 IESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAPE ..:.::.::...:.:.:::::. :.:.:: : : CCDS11 VKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPV 660 670 680 690 700 710 950 960 970 pF1KE2 AGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI CCDS11 VSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL 720 730 740 750 >>CCDS45715.1 MAPT gene_id:4137|Hs108|chr17 (776 aa) initn: 477 init1: 477 opt: 582 Z-score: 346.0 bits: 75.1 E(32554): 5.9e-13 Smith-Waterman score: 696; 31.5% identity (54.6% similar) in 606 aa overlap (337-916:163-707) 310 320 330 340 350 360 pF1KE2 ELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASP--IKMDL : :. :. : : .: .: .: CCDS45 QEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQL 140 150 160 170 180 190 370 380 390 400 410 pF1KE2 APS-KDMGPPKENKKETER-ASPIKMDLAPSKDMGPPKEN---KIVPAKDLVLLSEIEVA . .. ::: .. :: .: ..: . : . :... : ::.: .: CCDS45 LGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDG--RPPQTAA 200 210 220 230 240 250 420 430 440 450 460 470 pF1KE2 QANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLE----AEVAPV . : . .: . .. ..:. . : .: .: . ::: .:..: CCDS45 REATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPN 260 270 280 290 300 310 480 490 500 510 520 530 pF1KE2 --KDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLI-- :..:. : : ::. :. . : .:. : :. : : . . CCDS45 VQKEQAHSEEHLGRAAFPGAPGEGPEA---RGPSLGEDTKEA---DLPEPSEKQPAAAPR 320 330 340 350 360 540 550 560 570 580 pF1KE2 -KNVCLPPEME---VALTEDQVPALKTEAPTTIGGLNKKPMSLASGLVPAAPPKRPAVAS : : :... :. ..: . . .: :. . : .: . : ::.:. .: CCDS45 GKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAK---TLKNR--PCLSPKHPTPGS 370 380 390 400 410 590 600 610 620 630 640 pF1KE2 ARPSILPSKD-VKPKPIADAKAPEKRAS-PSKPASAPASRSGSKSTQTVAKTTTAAAVAS . : : ::. : :.: ..:. .: :. .:. :.. :... .: .: ..: CCDS45 SDPLIQPSSPAVCPEP---PSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAP 420 430 440 450 460 470 650 660 670 680 690 700 pF1KE2 TGPSSRSPSTLLPKK-PTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSG : .... .: .: : : : :: . : .:.. . :: :.: :. . CCDS45 PGQKGQANATRIPAKTPPAPKTPPSSA-TKQVQRRPPPAG---PRSERGEPPKSGDRSGY 480 490 500 510 520 530 710 720 730 740 750 760 pF1KE2 TAPAAGVVP-SRVKATPMPSRPSTTPFIDKKPTSAK--PSSTTPRLSRLATN-TSAPDLK ..:.. .: :: .. .:. :. : :: . .. :.: . ::: : . :::: CCDS45 SSPGSPGTPGSRSRTPSLPTPPTREP---KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLK 540 550 560 570 580 770 780 790 800 810 820 pF1KE2 NVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQ ::.::.:::::.::::::: ::: CCDS45 NVKSKIGSTENLKHQPGGG--------------------------------------KVQ 590 600 610 830 840 850 860 870 880 pF1KE2 IVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGD :..::.. :..:::::::::::::::::.::: : ::.:::.::::: .::.::::::. CCDS45 IINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQ 620 630 640 650 660 670 890 900 910 920 930 940 pF1KE2 VKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAA :...:.::.::...:.:.:::::. :.:.:: : : CCDS45 VEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKS 680 690 700 710 720 730 950 960 970 pF1KE2 PEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI CCDS45 PVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL 740 750 760 770 >>CCDS33369.1 MAP2 gene_id:4133|Hs108|chr2 (559 aa) initn: 892 init1: 455 opt: 575 Z-score: 344.3 bits: 74.3 E(32554): 7.4e-13 Smith-Waterman score: 627; 34.1% identity (55.5% similar) in 425 aa overlap (508-916:124-490) 480 490 500 510 520 530 pF1KE2 MAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPP-PETE-VVLIKNVC ::. : : :: : .: .: .... CCDS33 IVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEAA 100 110 120 130 140 150 540 550 560 570 580 pF1KE2 -----LPPEMEVALTEDQVPALKTEAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASA-- : : . ..:.: .. : .:.: :. :.. :: . ... CCDS33 GGESALAPSV-FKQAKDKVSNSTLSKIPALQGSTKSPR--YSSACPSTT-KRATFSDSLL 160 170 180 190 200 590 600 610 620 630 640 pF1KE2 -RPSILPSKDVKPKPIAD-----AKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAA .:. : : : . .:.::::.: .:.: : : .. . . . .. CCDS33 IQPTSAGSTDRLPYSKSGNKDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSS 210 220 230 240 250 260 650 660 670 680 690 700 pF1KE2 VASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSR-PKSTSTSSMKKTTT ..:.. . . .. .: :. . .: . :. :: : . .: :. .: CCDS33 ISSSARRTTRSEPIRRAGKSGTSTPTTPGSTA-ITPGTPPSYSSRTPGTPGTPSYPRTPH 270 280 290 300 310 320 710 720 730 740 750 760 pF1KE2 LSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKN :: .: .:::. :.. . . : :.:. ::. :: : ::::: CCDS33 TPGTPKSAILVPSEKKVAIIRTPP-------KSPA-------TPKQLRLI-NQPLPDLKN 330 340 350 360 370 770 780 790 800 810 820 pF1KE2 VRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQI :.::.:::.:::.:: :: .:.: CCDS33 VKSKIGSTDNIKYQPKGG--------------------------------------QVRI 380 390 830 840 850 860 870 880 pF1KE2 VSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDV ..::...:..::.::::::::: ::::::: .::.:.:.:.::::: ::.:.:::: : CCDS33 LNKKIDFSKVQSRCGSKDNIKHSAGGGNVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRV 400 410 420 430 440 450 890 900 910 920 930 940 pF1KE2 KIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAP :::: ::.::::::::::::::. :.:.:: :: . CCDS33 KIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSP 460 470 480 490 500 510 950 960 970 pF1KE2 EAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI CCDS33 GRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL 520 530 540 550 >>CCDS11499.1 MAPT gene_id:4137|Hs108|chr17 (441 aa) initn: 477 init1: 477 opt: 570 Z-score: 343.0 bits: 73.8 E(32554): 8.7e-13 Smith-Waterman score: 640; 36.1% identity (59.9% similar) in 379 aa overlap (559-916:39-372) 530 540 550 560 570 580 pF1KE2 VLIKNVCLPPEMEVALTEDQVPALKTEAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASA : .::...:.. . : .. . :.. CCDS11 EVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKS 10 20 30 40 50 60 590 600 610 620 630 640 pF1KE2 RPSILPSKDVKPKPIADAKAPEKRASPSK----PASAPASRSGSKSTQTV----AKTTTA :. ..:: :..: :: :.:. . : .. : ..: .: .. : .: CCDS11 TPT---AEDVTA-PLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQ 70 80 90 100 110 120 650 660 670 680 690 pF1KE2 AAVAS-----TGPSSRSPSTLLPKKPTAI-KTEGKPAEVKKMTAKSVPADLS-RPKSTST : ..: :: .... . : : . . :.. . .: .:: ::. . CCDS11 ARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPS 130 140 150 160 170 180 700 710 720 730 740 pF1KE2 SSMK-KTTTLSG-TAPAAGVVP-SRVKATPMPSRPSTTPFIDKKPTSAK--PSSTTPRLS :. :. :: ..:.. .: :: .. .:. :. : :: . .. :.: . : CCDS11 SGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP---KKVAVVRTPPKSPSSAKS 190 200 210 220 230 240 750 760 770 780 790 800 pF1KE2 RLATN-TSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGP :: : . ::::::.::.:::::.::::::: CCDS11 RLQTAPVPMPDLKNVKSKIGSTENLKHQPGGG---------------------------- 250 260 270 810 820 830 840 850 860 pF1KE2 IASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCG ::::..::.. :..:::::::::::::::::.::: : ::.:::.:::: CCDS11 ----------KVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCG 280 290 300 310 320 870 880 890 900 910 920 pF1KE2 SKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPG : .::.::::::.:...:.::.::...:.:.:::::. :.:.:: : : CCDS11 SLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAK 330 340 350 360 370 380 930 940 950 960 970 pF1KE2 PPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI CCDS11 AKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL 390 400 410 420 430 440 >>CCDS45716.1 MAPT gene_id:4137|Hs108|chr17 (412 aa) initn: 477 init1: 477 opt: 555 Z-score: 335.0 bits: 72.2 E(32554): 2.4e-12 Smith-Waterman score: 635; 33.7% identity (58.5% similar) in 386 aa overlap (538-916:4-343) 510 520 530 540 550 560 pF1KE2 PLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPTTIGG--LNK :..: . ::.. . :: ... CCDS45 MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQ 10 20 30 570 580 590 600 610 620 pF1KE2 KPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASR . ... . .: . :. ... ..:.: : :.:. .:: : . CCDS45 DQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEAEEAGIGDTPSLEDEAAGHV 40 50 60 70 80 90 630 640 650 660 670 680 pF1KE2 SGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADL . .. .. : . . : .... . :. . .:. :.. .. ::. :: CCDS45 TQARMVSKSKDGTGSDDKKAKGADGKT-KIATPRGAAPPGQKGQ-ANATRIPAKTPPAPK 100 110 120 130 140 150 690 700 710 720 730 740 pF1KE2 SRPKSTSTSSMKKTTTLSG-TAPAAGVVP-SRVKATPMPSRPSTTPFIDKKPTSAK--PS . : :.. :. :: ..:.. .: :: .. .:. :. : :: . .. :. CCDS45 TPP---SSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP---KKVAVVRTPPK 160 170 180 190 200 750 760 770 780 790 800 pF1KE2 STTPRLSRLATN-TSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNA : . ::: : . ::::::.::.:::::.::::::: CCDS45 SPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGG--------------------- 210 220 230 240 810 820 830 840 850 860 pF1KE2 VTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDIS ::::..::.. :..:::::::::::::::::.::: : ::.: CCDS45 -----------------KVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLS 250 260 270 280 870 880 890 900 910 920 pF1KE2 KVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGS ::.::::: .::.::::::.:...:.::.::...:.:.:::::. :.:.:: : : CCDS45 KVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKL 290 300 310 320 330 340 930 940 950 960 970 pF1KE2 EAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI CCDS45 TFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASL 350 360 370 380 390 400 >>CCDS11500.1 MAPT gene_id:4137|Hs108|chr17 (383 aa) initn: 477 init1: 477 opt: 543 Z-score: 328.7 bits: 70.9 E(32554): 5.4e-12 Smith-Waterman score: 606; 42.4% identity (64.0% similar) in 264 aa overlap (658-916:96-314) 630 640 650 660 670 680 pF1KE2 SKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSR :. . .:. :.. .. ::. :: . CCDS11 QARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQ-ANATRIPAKTPPAPKTP 70 80 90 100 110 120 690 700 710 720 730 740 pF1KE2 PKSTSTSSMKKTTTLSG-TAPAAGVVP-SRVKATPMPSRPSTTPFIDKKPTSAK--PSST : :.. :. :: ..:.. .: :: .. .:. :. : :: . .. :.: CCDS11 P---SSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP---KKVAVVRTPPKSP 130 140 150 160 170 750 760 770 780 790 800 pF1KE2 TPRLSRLATN-TSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVT . ::: : . ::::::.::.:::::.::::::: CCDS11 SSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGG----------------------- 180 190 200 210 810 820 830 840 850 860 pF1KE2 KTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKV ::::..::.. :..:::::::::::::::::.::: : ::.::: CCDS11 ---------------KVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKV 220 230 240 250 260 870 880 890 900 910 920 pF1KE2 SSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEA .::::: .::.::::::.:...:.::.::...:.:.:::::. :.:.:: : : CCDS11 TSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF 270 280 290 300 310 320 930 940 950 960 970 pF1KE2 PLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI CCDS11 RENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAK 330 340 350 360 370 380 979 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 16:59:30 2016 done: Tue Nov 8 16:59:31 2016 Total Scan time: 3.270 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]