Result of FASTA (omim) for
pF1KE2627
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2627, 271 aa
1>>>pF1KE2627 271 - 271 aa - 271 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9281+/-0.000359; mu= 17.0555+/- 0.022
mean_var=66.1578+/-13.886, 0's: 0 Z-trim(113.9): 44 B-trim: 0 in 0/51
Lambda= 0.157683
statistics sampled from 23345 (23391) to 23345 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.651), E-opt: 0.2 (0.274), width: 16
Scan time: 7.470
The best scores are: opt bits E(85289)
NP_000477 (OMIM: 107777,125800) aquaporin-2 [Homo ( 271) 1772 411.8 6.7e-115
NP_001642 (OMIM: 600442) aquaporin-5 [Homo sapiens ( 265) 1158 272.1 7.4e-73
NP_036196 (OMIM: 154050,615274) lens fiber major i ( 263) 1082 254.8 1.2e-67
NP_001643 (OMIM: 601383) aquaporin-6 [Homo sapiens ( 282) 993 234.6 1.5e-61
XP_005268895 (OMIM: 600442) PREDICTED: aquaporin-5 ( 222) 916 217.0 2.4e-56
NP_004019 (OMIM: 600308) aquaporin-4 isoform M23 [ ( 301) 776 185.3 1.2e-46
XP_011524244 (OMIM: 600308) PREDICTED: aquaporin-4 ( 316) 776 185.3 1.2e-46
NP_001641 (OMIM: 600308) aquaporin-4 isoform M1 [H ( 323) 776 185.3 1.2e-46
NP_001304313 (OMIM: 600308) aquaporin-4 isoform M1 ( 352) 776 185.3 1.3e-46
NP_932766 (OMIM: 107776,110450) aquaporin-1 isofor ( 269) 768 183.4 3.8e-46
NP_001316801 (OMIM: 107776,110450) aquaporin-1 iso ( 323) 768 183.5 4.4e-46
XP_016874795 (OMIM: 154050,615274) PREDICTED: lens ( 144) 563 136.6 2.6e-32
XP_011536656 (OMIM: 154050,615274) PREDICTED: lens ( 168) 563 136.6 2.9e-32
NP_001304316 (OMIM: 600308) aquaporin-4 isoform de ( 296) 555 135.0 1.6e-31
NP_001160 (OMIM: 603750) aquaporin-8 [Homo sapiens ( 261) 420 104.2 2.5e-22
XP_011544124 (OMIM: 603750) PREDICTED: aquaporin-8 ( 262) 420 104.2 2.5e-22
NP_001307564 (OMIM: 602914) aquaporin-9 isoform 2 ( 193) 196 53.2 4.4e-07
NP_066190 (OMIM: 602914) aquaporin-9 isoform 1 [Ho ( 295) 196 53.3 6.1e-07
NP_001305086 (OMIM: 602974,614411) aquaporin-7 iso ( 256) 191 52.1 1.2e-06
NP_001305087 (OMIM: 602974,614411) aquaporin-7 iso ( 257) 191 52.1 1.2e-06
XP_016870189 (OMIM: 602974,614411) PREDICTED: aqua ( 341) 191 52.2 1.5e-06
XP_005251510 (OMIM: 602974,614411) PREDICTED: aqua ( 342) 191 52.2 1.5e-06
XP_011516168 (OMIM: 602974,614411) PREDICTED: aqua ( 342) 191 52.2 1.5e-06
NP_001161 (OMIM: 602974,614411) aquaporin-7 isofor ( 342) 191 52.2 1.5e-06
XP_011544125 (OMIM: 603750) PREDICTED: aquaporin-8 ( 148) 184 50.4 2.4e-06
XP_016870194 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 183 50.3 4.1e-06
XP_016870193 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 183 50.3 4.1e-06
XP_016870190 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 183 50.3 4.1e-06
XP_016870192 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 183 50.3 4.1e-06
XP_016870191 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 183 50.3 4.1e-06
NP_001305073 (OMIM: 600170,607457) aquaporin-3 iso ( 237) 182 50.1 4.7e-06
NP_004916 (OMIM: 600170,607457) aquaporin-3 isofor ( 292) 180 49.7 7.5e-06
NP_536354 (OMIM: 606578) aquaporin-10 [Homo sapien ( 301) 151 43.1 0.00074
NP_001307565 (OMIM: 602914) aquaporin-9 isoform 3 ( 230) 148 42.3 0.00097
XP_016870195 (OMIM: 602974,614411) PREDICTED: aqua ( 200) 143 41.1 0.0019
XP_011508406 (OMIM: 606578) PREDICTED: aquaporin-1 ( 302) 145 41.7 0.0019
NP_001305085 (OMIM: 602974,614411) aquaporin-7 iso ( 216) 143 41.2 0.002
XP_006716828 (OMIM: 602974,614411) PREDICTED: aqua ( 285) 143 41.3 0.0025
XP_011516169 (OMIM: 602974,614411) PREDICTED: aqua ( 285) 143 41.3 0.0025
>>NP_000477 (OMIM: 107777,125800) aquaporin-2 [Homo sapi (271 aa)
initn: 1772 init1: 1772 opt: 1772 Z-score: 2183.8 bits: 411.8 E(85289): 6.7e-115
Smith-Waterman score: 1772; 100.0% identity (100.0% similar) in 271 aa overlap (1-271:1-271)
10 20 30 40 50 60
pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 HISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 CSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGL
190 200 210 220 230 240
250 260 270
pF1KE2 EPDTDWEEREVRRRQSVELHSPQSLPRGTKA
:::::::::::::::::::::::::::::::
NP_000 EPDTDWEEREVRRRQSVELHSPQSLPRGTKA
250 260 270
>>NP_001642 (OMIM: 600442) aquaporin-5 [Homo sapiens] (265 aa)
initn: 1170 init1: 892 opt: 1158 Z-score: 1429.0 bits: 272.1 E(85289): 7.4e-73
Smith-Waterman score: 1158; 66.0% identity (90.3% similar) in 259 aa overlap (3-259:4-262)
10 20 30 40 50
pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQAL
:. :.:: .::::::::::.::::::::::.::.:::..::::.::::.::::.:::
NP_001 MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQAL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 GHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVN
: .::.:::::.:.: ::: ..:.::: :::::::.::.:::..:. ..: . ::.::::
NP_001 GPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 ALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYT
::.:.:: :::..:::.::.::.:::::::: :: :.::::::.::.::::.::..:
NP_001 ALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFT
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 GCSMNPARSLAPAVVTGKFDD-HWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLK
:::::::::..:::: ..:. :::::.::.:::.:...:: :.::: . :::::.:..:
NP_001 GCSMNPARSFGPAVVMNRFSPAHWVFWVGPIVGAVLAAILYFYLLFPNSLSLSERVAIIK
190 200 210 220 230 240
240 250 260 270
pF1KE2 GL-EPDTDWEEREVRRRQSVELHSPQSLPRGTKA
: ::: ::::.. .:....::
NP_001 GTYEPDEDWEEQREERKKTMELTTR
250 260
>>NP_036196 (OMIM: 154050,615274) lens fiber major intri (263 aa)
initn: 1077 init1: 1077 opt: 1082 Z-score: 1335.6 bits: 254.8 E(85289): 1.2e-67
Smith-Waterman score: 1082; 61.5% identity (86.4% similar) in 265 aa overlap (1-265:1-263)
10 20 30 40 50 60
pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALG
:::::: .: ::.::::.:::..:::::::.: : . :::.::::::...::::..:
NP_036 MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 HISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNA
::::::.::::: : ::: ..:.::: :.::::::::::::.:. .:: .::.::.:.
NP_036 HISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTG
: ....:::.:::.:::::.::::::. ::::. . :. ::..:::.:::::.:..:::
NP_036 LHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 CSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGL
.::::::.:::..::.: .:::.:.::..:. ::::::...::: ::.::::.::::
NP_036 AGMNPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLSVLKGA
190 200 210 220 230 240
250 260 270
pF1KE2 EPDTDWEEREVRRRQSVELHSPQSLPRGTKA
.::.. . :: . :::.. :.:
NP_036 KPDVSNGQPEVTG-EPVELNT-QAL
250 260
>>NP_001643 (OMIM: 601383) aquaporin-6 [Homo sapiens] (282 aa)
initn: 977 init1: 574 opt: 993 Z-score: 1225.8 bits: 234.6 E(85289): 1.5e-61
Smith-Waterman score: 993; 62.3% identity (85.4% similar) in 239 aa overlap (1-239:19-251)
10 20 30 40
pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVL
.:. :.:::.::::::: :.::::.::.. :: ::::::
NP_001 MDAVEPGGRGWASMLACRLWK----AISRALFAEFLATGLYVFFGVGSVMRWPTALPSVL
10 20 30 40 50
50 60 70 80 90 100
pF1KE2 QIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAA
:::..:.: . ::. . :::: :::::.: ::: :.:. ::. ::::::.::..:::
NP_001 QIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAA
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE2 LLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPAL
::. . :.::: :..:.. ::...::::.:::.::::::::.::::: : .. :.::
NP_001 LLYGVMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSR--QTSGSPAT
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 SIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYV
::.:::::::.:::.::::::::::..::.. ::: :::::.:::.::.:.::.::.:
NP_001 MIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFV
180 190 200 210 220 230
230 240 250 260 270
pF1KE2 LFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA
::: .:.:..:::.: :
NP_001 LFPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV
240 250 260 270 280
>>XP_005268895 (OMIM: 600442) PREDICTED: aquaporin-5 iso (222 aa)
initn: 918 init1: 892 opt: 916 Z-score: 1132.6 bits: 217.0 E(85289): 2.4e-56
Smith-Waterman score: 916; 68.7% identity (91.0% similar) in 201 aa overlap (3-202:4-204)
10 20 30 40 50
pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQAL
:. :.:: .::::::::::.::::::::::.::.:::..::::.::::.::::.:::
XP_005 MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQAL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 GHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVN
: .::.:::::.:.: ::: ..:.::: :::::::.::.:::..:. ..: . ::.::::
XP_005 GPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 ALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYT
::.:.:: :::..:::.::.::.:::::::: :: :.::::::.::.::::.::..:
XP_005 ALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFT
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 GCSMNPARSLAPAVVTGKFDD-HWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLK
:::::::::..:::: ..:. ::
XP_005 GCSMNPARSFGPAVVMNRFSPAHWGLLLSLRGGDTRSVHPSL
190 200 210 220
>>NP_004019 (OMIM: 600308) aquaporin-4 isoform M23 [Homo (301 aa)
initn: 775 init1: 677 opt: 776 Z-score: 958.6 bits: 185.3 E(85289): 1.2e-46
Smith-Waterman score: 776; 51.4% identity (82.9% similar) in 222 aa overlap (8-225:11-232)
10 20 30 40 50
pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNW---PQALP-SVLQIAMAFGLGIG
:: .:: ::::: :.::...:::..:: . :: ... :.. :::.:.
NP_004 MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 TLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIR
:.:: .:::::.::::::::: . ..:. ...::.::: :::. ::..:. .:: ..
NP_004 TMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVV
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 GDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHL
: :.:. . .. :::... :::..:.:::. :::: : .: . :. ::.::::::.:::
NP_004 GGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 LGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSER
..:.::: :::::::..:::. :....::..:.::..::.:.. ::.::. :
NP_004 FAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRF
190 200 210 220 230 240
240 250 260 270
pF1KE2 LAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA
NP_004 KEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSS
250 260 270 280 290 300
>>XP_011524244 (OMIM: 600308) PREDICTED: aquaporin-4 iso (316 aa)
initn: 775 init1: 677 opt: 776 Z-score: 958.3 bits: 185.3 E(85289): 1.2e-46
Smith-Waterman score: 776; 51.4% identity (82.9% similar) in 222 aa overlap (8-225:26-247)
10 20 30
pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNW---PQALP
:: .:: ::::: :.::...:::..:: . ::
XP_011 MFEIKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLP
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 -SVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAV
... :.. :::.:.:.:: .:::::.::::::::: . ..:. ...::.::: :::.
XP_011 VDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAI
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 AGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPG
::..:. .:: .. : :.:. . .. :::... :::..:.:::. :::: : .: . :
XP_011 IGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTG
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 TPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLL
. ::.::::::.:::..:.::: :::::::..:::. :....::..:.::..::.:.. :
XP_011 SIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGL
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 YNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA
:.::. :
XP_011 YEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRG
250 260 270 280 290 300
>>NP_001641 (OMIM: 600308) aquaporin-4 isoform M1 [Homo (323 aa)
initn: 775 init1: 677 opt: 776 Z-score: 958.2 bits: 185.3 E(85289): 1.2e-46
Smith-Waterman score: 776; 51.4% identity (82.9% similar) in 222 aa overlap (8-225:33-254)
10 20 30
pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNW---
:: .:: ::::: :.::...:::..::
NP_001 DRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGT
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 PQALP-SVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQ
. :: ... :.. :::.:.:.:: .:::::.::::::::: . ..:. ...::.:::
NP_001 EKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQ
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 LLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERR
:::. ::..:. .:: .. : :.:. . .. :::... :::..:.:::. :::: : .:
NP_001 CLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKR
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 GENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAI
. :. ::.::::::.:::..:.::: :::::::..:::. :....::..:.::..::.
NP_001 TDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAV
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 LGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA
:.. ::.::. :
NP_001 LAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVI
250 260 270 280 290 300
>>NP_001304313 (OMIM: 600308) aquaporin-4 isoform M1x [H (352 aa)
initn: 775 init1: 677 opt: 776 Z-score: 957.6 bits: 185.3 E(85289): 1.3e-46
Smith-Waterman score: 776; 51.4% identity (82.9% similar) in 222 aa overlap (8-225:33-254)
10 20 30
pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNW---
:: .:: ::::: :.::...:::..::
NP_001 DRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGT
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 PQALP-SVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQ
. :: ... :.. :::.:.:.:: .:::::.::::::::: . ..:. ...::.:::
NP_001 EKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQ
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 LLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERR
:::. ::..:. .:: .. : :.:. . .. :::... :::..:.:::. :::: : .:
NP_001 CLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKR
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 GENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAI
. :. ::.::::::.:::..:.::: :::::::..:::. :....::..:.::..::.
NP_001 TDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAV
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 LGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA
:.. ::.::. :
NP_001 LAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVI
250 260 270 280 290 300
>>NP_932766 (OMIM: 107776,110450) aquaporin-1 isoform 1 (269 aa)
initn: 787 init1: 664 opt: 768 Z-score: 949.4 bits: 183.4 E(85289): 3.8e-46
Smith-Waterman score: 768; 45.0% identity (79.6% similar) in 260 aa overlap (3-254:4-263)
10 20 30 40 50
pF1KE2 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALN--WP-----QALPSVLQIAMAFGLGI
:... : ::: :::::: ::::...::::. .: :. . .....::::.:
NP_932 MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 GTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADI
.::.:..:::::::.:::::.. :..:..:..:: .:. :: .::....:.: :: .
NP_932 ATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 RGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGH
..:. : :......::.. .:.. :::::::..:.::.:: . :. :.::.::::::
NP_932 GNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGH
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 LLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSE
::.: ::::..:::::.. ::.: .:..::.::.::..:. :. :.:...: : ...:..
NP_932 LLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTD
190 200 210 220 230 240
240 250 260 270
pF1KE2 RLAV-LKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA
:. : .: . : . .. :
NP_932 RVKVWTSGQVEEYDLDADDINSRVEMKPK
250 260
271 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 10:52:21 2016 done: Sun Nov 6 10:52:22 2016
Total Scan time: 7.470 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]