Result of FASTA (omim) for
pF1KE2635
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2635, 390 aa
1>>>pF1KE2635 390 - 390 aa - 390 aa
Library: /omim/omim.rfq.tfa
64092750 residues in 91774 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7696+/-0.000435; mu= 14.6187+/- 0.027
mean_var=78.6494+/-15.859, 0's: 0 Z-trim(111.1): 411 B-trim: 518 in 1/50
Lambda= 0.144619
statistics sampled from 19861 (20299) to 19861 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.59), E-opt: 0.2 (0.221), width: 16
Scan time: 3.660
The best scores are: opt bits E(91774)
NP_001010000 (OMIM: 610592) rho GTPase-activating ( 570) 2535 539.0 1.1e-152
NP_001353159 (OMIM: 610592) rho GTPase-activating ( 729) 2535 539.0 1.4e-152
NP_001353160 (OMIM: 610592) rho GTPase-activating ( 722) 2171 463.1 1e-129
XP_005258203 (OMIM: 610592) rho GTPase-activating ( 721) 1957 418.5 2.8e-116
NP_277050 (OMIM: 613351) rho GTPase-activating pro ( 663) 991 216.9 1.2e-55
XP_005267269 (OMIM: 613351) rho GTPase-activating ( 713) 991 216.9 1.3e-55
XP_005267270 (OMIM: 613351) rho GTPase-activating ( 585) 845 186.4 1.6e-46
XP_016866983 (OMIM: 613351) rho GTPase-activating ( 635) 845 186.4 1.7e-46
XP_024309638 (OMIM: 613299) protein FAM13A isoform ( 584) 310 74.8 6.5e-13
XP_024308768 (OMIM: 610578) rho GTPase-activating ( 241) 303 73.1 8.5e-13
XP_024308769 (OMIM: 610578) rho GTPase-activating ( 241) 303 73.1 8.5e-13
XP_016863113 (OMIM: 613299) protein FAM13A isoform ( 981) 310 74.9 1e-12
XP_005262740 (OMIM: 613299) protein FAM13A isoform ( 995) 310 74.9 1e-12
XP_005262739 (OMIM: 613299) protein FAM13A isoform (1003) 310 74.9 1e-12
XP_005262738 (OMIM: 613299) protein FAM13A isoform (1009) 310 74.9 1e-12
XP_011529818 (OMIM: 613299) protein FAM13A isoform (1023) 310 74.9 1e-12
NP_055698 (OMIM: 613299) protein FAM13A isoform a (1023) 310 74.9 1e-12
XP_011509785 (OMIM: 610578) rho GTPase-activating ( 397) 303 73.2 1.3e-12
XP_016859989 (OMIM: 610578) rho GTPase-activating ( 432) 303 73.2 1.4e-12
NP_060930 (OMIM: 610578) rho GTPase-activating pro ( 475) 303 73.3 1.5e-12
XP_016859988 (OMIM: 610578) rho GTPase-activating ( 475) 303 73.3 1.5e-12
XP_011509781 (OMIM: 610578) rho GTPase-activating ( 475) 303 73.3 1.5e-12
XP_011529819 (OMIM: 613299) protein FAM13A isoform ( 995) 291 70.9 1.6e-11
NP_001335012 (OMIM: 114500,604258) rho GTPase-acti (1017) 290 70.7 1.9e-11
NP_001157743 (OMIM: 114500,604258) rho GTPase-acti (1017) 290 70.7 1.9e-11
NP_001335011 (OMIM: 114500,604258) rho GTPase-acti (1017) 290 70.7 1.9e-11
NP_001335013 (OMIM: 114500,604258) rho GTPase-acti (1017) 290 70.7 1.9e-11
NP_006085 (OMIM: 114500,604258) rho GTPase-activat (1091) 290 70.7 2e-11
NP_001303597 (OMIM: 114500,604258) rho GTPase-acti (1125) 290 70.8 2e-11
NP_001243776 (OMIM: 600365) active breakpoint clus ( 310) 282 68.8 2.2e-11
NP_872584 (OMIM: 114500,604258) rho GTPase-activat (1528) 290 70.8 2.6e-11
NP_001335010 (OMIM: 114500,604258) rho GTPase-acti (1528) 290 70.8 2.6e-11
XP_005273431 (OMIM: 114500,604258) rho GTPase-acti (1528) 290 70.8 2.6e-11
XP_016863114 (OMIM: 613299) protein FAM13A isoform ( 968) 286 69.9 3.2e-11
XP_016872443 (OMIM: 610577) rho GTPase-activating ( 742) 284 69.4 3.4e-11
NP_001257627 (OMIM: 610577) rho GTPase-activating ( 769) 284 69.4 3.5e-11
XP_011518063 (OMIM: 610577) rho GTPase-activating ( 772) 284 69.4 3.5e-11
XP_005252701 (OMIM: 610577) rho GTPase-activating ( 794) 284 69.4 3.6e-11
NP_001257628 (OMIM: 610577) rho GTPase-activating ( 794) 284 69.4 3.6e-11
NP_001257626 (OMIM: 610577) rho GTPase-activating ( 799) 284 69.4 3.6e-11
NP_001257625 (OMIM: 610577) rho GTPase-activating ( 816) 284 69.4 3.7e-11
NP_001257624 (OMIM: 610577) rho GTPase-activating ( 841) 284 69.4 3.8e-11
NP_060757 (OMIM: 610577) rho GTPase-activating pro ( 846) 284 69.4 3.8e-11
NP_001269078 (OMIM: 600365) active breakpoint clus ( 641) 282 68.9 4e-11
NP_001309769 (OMIM: 600365) active breakpoint clus ( 813) 282 69.0 4.9e-11
NP_001153218 (OMIM: 600365) active breakpoint clus ( 813) 282 69.0 4.9e-11
NP_001083 (OMIM: 600365) active breakpoint cluster ( 822) 282 69.0 5e-11
NP_068781 (OMIM: 600365) active breakpoint cluster ( 859) 282 69.0 5.1e-11
NP_001309770 (OMIM: 600365) active breakpoint clus (1118) 282 69.1 6.4e-11
NP_067585 (OMIM: 151410,608232,613065) breakpoint (1227) 282 69.1 6.9e-11
>>NP_001010000 (OMIM: 610592) rho GTPase-activating prot (570 aa)
initn: 2535 init1: 2535 opt: 2535 Z-score: 2862.4 bits: 539.0 E(91774): 1.1e-152
Smith-Waterman score: 2535; 99.7% identity (99.7% similar) in 390 aa overlap (1-390:181-570)
10 20 30
pF1KE2 MKKIRHLSLIELTAFFDAFGIQLKRNKTEK
::::::::::::::::::::::::::::::
NP_001 IKKEDYVLTKFNVQKTRFGLTEAGDLSAEDMKKIRHLSLIELTAFFDAFGIQLKRNKTEK
160 170 180 190 200 210
40 50 60 70 80 90
pF1KE2 VKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKV
220 230 240 250 260 270
100 110 120 130 140 150
pF1KE2 KQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHV
280 290 300 310 320 330
160 170 180 190 200 210
pF1KE2 KVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSK
340 350 360 370 380 390
220 230 240 250 260 270
pF1KE2 HSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLR
400 410 420 430 440 450
280 290 300 310 320 330
pF1KE2 RKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAKDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAKDIL
460 470 480 490 500 510
340 350 360 370 380 390
pF1KE2 AKFQYENSHGSSECIKIQNQRLYEIGGNIGEHCLDPDAYILDVYRINPQAEWVIKPQPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
NP_001 AKFQYENSHGSSECIKIQNQRLYEIGGNIGEHCLDPDAYILDVYRINPQAEWVIKPQQSS
520 530 540 550 560 570
>>NP_001353159 (OMIM: 610592) rho GTPase-activating prot (729 aa)
initn: 2535 init1: 2535 opt: 2535 Z-score: 2860.8 bits: 539.0 E(91774): 1.4e-152
Smith-Waterman score: 2535; 99.7% identity (99.7% similar) in 390 aa overlap (1-390:340-729)
10 20 30
pF1KE2 MKKIRHLSLIELTAFFDAFGIQLKRNKTEK
::::::::::::::::::::::::::::::
NP_001 IKKEDYVLTKFNVQKTRFGLTEAGDLSAEDMKKIRHLSLIELTAFFDAFGIQLKRNKTEK
310 320 330 340 350 360
40 50 60 70 80 90
pF1KE2 VKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKV
370 380 390 400 410 420
100 110 120 130 140 150
pF1KE2 KQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHV
430 440 450 460 470 480
160 170 180 190 200 210
pF1KE2 KVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSK
490 500 510 520 530 540
220 230 240 250 260 270
pF1KE2 HSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLR
550 560 570 580 590 600
280 290 300 310 320 330
pF1KE2 RKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAKDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAKDIL
610 620 630 640 650 660
340 350 360 370 380 390
pF1KE2 AKFQYENSHGSSECIKIQNQRLYEIGGNIGEHCLDPDAYILDVYRINPQAEWVIKPQPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
NP_001 AKFQYENSHGSSECIKIQNQRLYEIGGNIGEHCLDPDAYILDVYRINPQAEWVIKPQQSS
670 680 690 700 710 720
>>NP_001353160 (OMIM: 610592) rho GTPase-activating prot (722 aa)
initn: 2171 init1: 2171 opt: 2171 Z-score: 2450.5 bits: 463.1 E(91774): 1e-129
Smith-Waterman score: 2171; 100.0% identity (100.0% similar) in 337 aa overlap (1-337:340-676)
10 20 30
pF1KE2 MKKIRHLSLIELTAFFDAFGIQLKRNKTEK
::::::::::::::::::::::::::::::
NP_001 IKKEDYVLTKFNVQKTRFGLTEAGDLSAEDMKKIRHLSLIELTAFFDAFGIQLKRNKTEK
310 320 330 340 350 360
40 50 60 70 80 90
pF1KE2 VKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKV
370 380 390 400 410 420
100 110 120 130 140 150
pF1KE2 KQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHV
430 440 450 460 470 480
160 170 180 190 200 210
pF1KE2 KVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSK
490 500 510 520 530 540
220 230 240 250 260 270
pF1KE2 HSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLR
550 560 570 580 590 600
280 290 300 310 320 330
pF1KE2 RKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAKDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAKDIL
610 620 630 640 650 660
340 350 360 370 380 390
pF1KE2 AKFQYENSHGSSECIKIQNQRLYEIGGNIGEHCLDPDAYILDVYRINPQAEWVIKPQPSS
:::::::
NP_001 AKFQYENRILHWQRAALSFLNGKWVKKEREESTETNRSPKHVFLFTIGLDIST
670 680 690 700 710 720
>>XP_005258203 (OMIM: 610592) rho GTPase-activating prot (721 aa)
initn: 1955 init1: 1955 opt: 1957 Z-score: 2209.2 bits: 418.5 E(91774): 2.8e-116
Smith-Waterman score: 2307; 93.1% identity (93.1% similar) in 390 aa overlap (1-390:358-721)
10 20 30
pF1KE2 MKKIRHLSLIELTAFFDAFGIQLKRNKTEK
::::::::::::::::::::::::::::::
XP_005 IKKEDYVLTKFNVQKTRFGLTEAGDLSAEDMKKIRHLSLIELTAFFDAFGIQLKRNKTEK
330 340 350 360 370 380
40 50 60 70 80 90
pF1KE2 VKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKV
:::::::::::::::::::::::::::::::::::
XP_005 VKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQK-------------------------
390 400 410 420
100 110 120 130 140 150
pF1KE2 KQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 -QYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHV
430 440 450 460 470 480
160 170 180 190 200 210
pF1KE2 KVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSK
490 500 510 520 530 540
220 230 240 250 260 270
pF1KE2 HSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLR
550 560 570 580 590 600
280 290 300 310 320 330
pF1KE2 RKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAKDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAKDIL
610 620 630 640 650 660
340 350 360 370 380 390
pF1KE2 AKFQYENSHGSSECIKIQNQRLYEIGGNIGEHCLDPDAYILDVYRINPQAEWVIKPQPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
XP_005 AKFQYENSHGSSECIKIQNQRLYEIGGNIGEHCLDPDAYILDVYRINPQAEWVIKPQQSS
670 680 690 700 710 720
>>NP_277050 (OMIM: 613351) rho GTPase-activating protein (663 aa)
initn: 1114 init1: 484 opt: 991 Z-score: 1120.5 bits: 216.9 E(91774): 1.2e-55
Smith-Waterman score: 1180; 46.3% identity (78.3% similar) in 391 aa overlap (1-388:284-662)
10 20 30
pF1KE2 MKKIRHLSLIELTAFFDAFGIQLKRNKTEK
:::. ::.::::::..:..::.::..:. :
NP_277 SKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVLGIELKQQKAVK
260 270 280 290 300 310
40 50 60 70 80 90
pF1KE2 VKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKV
.: .:.:.: ::::.::. :..: ::...::..::.. ..:: :::.::..:. : . ..
NP_277 IKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRI
320 330 340 350 360 370
100 110 120 130 140 150
pF1KE2 KQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHV
:. .::.::: :.:... ...:: .:: :.:::: :. :::. :: .. . :
NP_277 KNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAFQAV-QNLPTK
380 390 400 410 420 430
160 170 180 190 200
pF1KE2 KVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRS-
: :.:::.:.:. :::::::. .::. :...:: :. ::.:.. :.. :::::::. ..
NP_277 KQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNLFMCHAL
440 450 460 470 480 490
210 220 230 240 250 260
pF1KE2 --KHSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRK
: :. .:...: .:. ..:..::::.:: .:.:...:::..: . ::. ...:
NP_277 GLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENH--KKDKRAMKK
500 510 520 530 540 550
270 280 290 300 310 320
pF1KE2 LLRRKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAK
::.. . .:: .:. .. .:::.:::::.:: ::::::::::... ::.
NP_277 LLKKMAYDREK--------YEKQDKSTNDADVPQGVIRVQAPHLSKVSMAIQLTEELKAS
560 570 580 590 600
330 340 350 360 370 380
pF1KE2 DILAKFQYENSHGSSECIKIQNQRLYEIGGNIGEHCLDPDAYILDVYRINPQAEWVIKPQ
:.::.: ..: : .. .: . ::::::::::.::: :.:. :.:..::.:::::: .
NP_277 DVLARFLSQES-GVAQTLKKGEVFLYEIGGNIGERCLDDDTYMKDLYQLNPNAEWVIKSK
610 620 630 640 650 660
390
pF1KE2 PSS
:
NP_277 PL
>>XP_005267269 (OMIM: 613351) rho GTPase-activating prot (713 aa)
initn: 1114 init1: 484 opt: 991 Z-score: 1120.0 bits: 216.9 E(91774): 1.3e-55
Smith-Waterman score: 1180; 46.3% identity (78.3% similar) in 391 aa overlap (1-388:334-712)
10 20 30
pF1KE2 MKKIRHLSLIELTAFFDAFGIQLKRNKTEK
:::. ::.::::::..:..::.::..:. :
XP_005 SKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVLGIELKQQKAVK
310 320 330 340 350 360
40 50 60 70 80 90
pF1KE2 VKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKV
.: .:.:.: ::::.::. :..: ::...::..::.. ..:: :::.::..:. : . ..
XP_005 IKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRI
370 380 390 400 410 420
100 110 120 130 140 150
pF1KE2 KQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHV
:. .::.::: :.:... ...:: .:: :.:::: :. :::. :: .. . :
XP_005 KNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAFQAV-QNLPTK
430 440 450 460 470 480
160 170 180 190 200
pF1KE2 KVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRS-
: :.:::.:.:. :::::::. .::. :...:: :. ::.:.. :.. :::::::. ..
XP_005 KQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNLFMCHAL
490 500 510 520 530 540
210 220 230 240 250 260
pF1KE2 --KHSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRK
: :. .:...: .:. ..:..::::.:: .:.:...:::..: . ::. ...:
XP_005 GLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENH--KKDKRAMKK
550 560 570 580 590 600
270 280 290 300 310 320
pF1KE2 LLRRKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAK
::.. . .:: .:. .. .:::.:::::.:: ::::::::::... ::.
XP_005 LLKKMAYDREK--------YEKQDKSTNDADVPQGVIRVQAPHLSKVSMAIQLTEELKAS
610 620 630 640 650
330 340 350 360 370 380
pF1KE2 DILAKFQYENSHGSSECIKIQNQRLYEIGGNIGEHCLDPDAYILDVYRINPQAEWVIKPQ
:.::.: ..: : .. .: . ::::::::::.::: :.:. :.:..::.:::::: .
XP_005 DVLARFLSQES-GVAQTLKKGEVFLYEIGGNIGERCLDDDTYMKDLYQLNPNAEWVIKSK
660 670 680 690 700 710
390
pF1KE2 PSS
:
XP_005 PL
>>XP_005267270 (OMIM: 613351) rho GTPase-activating prot (585 aa)
initn: 775 init1: 484 opt: 845 Z-score: 956.6 bits: 186.4 E(91774): 1.6e-46
Smith-Waterman score: 845; 44.6% identity (80.0% similar) in 280 aa overlap (1-277:284-560)
10 20 30
pF1KE2 MKKIRHLSLIELTAFFDAFGIQLKRNKTEK
:::. ::.::::::..:..::.::..:. :
XP_005 SKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVLGIELKQQKAVK
260 270 280 290 300 310
40 50 60 70 80 90
pF1KE2 VKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKV
.: .:.:.: ::::.::. :..: ::...::..::.. ..:: :::.::..:. : . ..
XP_005 IKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRI
320 330 340 350 360 370
100 110 120 130 140 150
pF1KE2 KQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHV
:. .::.::: :.:... ...:: .:: :.:::: :. :::. :: .... :
XP_005 KNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAFQAVQNL-PTK
380 390 400 410 420 430
160 170 180 190 200
pF1KE2 KVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRS-
: :.:::.:.:. :::::::. .::. :...:: :. ::.:.. :.. :::::::. ..
XP_005 KQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNLFMCHAL
440 450 460 470 480 490
210 220 230 240 250 260
pF1KE2 --KHSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRK
: :. .:...: .:. ..:..::::.:: .:.:...:::..: . ::. ...:
XP_005 GLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENH--KKDKRAMKK
500 510 520 530 540 550
270 280 290 300 310 320
pF1KE2 LLRRKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAK
::.. . .::
XP_005 LLKKMAYDREKYEKQDKSTNDWGCPDSQERRSFFV
560 570 580
>>XP_016866983 (OMIM: 613351) rho GTPase-activating prot (635 aa)
initn: 775 init1: 484 opt: 845 Z-score: 956.1 bits: 186.4 E(91774): 1.7e-46
Smith-Waterman score: 845; 44.6% identity (80.0% similar) in 280 aa overlap (1-277:334-610)
10 20 30
pF1KE2 MKKIRHLSLIELTAFFDAFGIQLKRNKTEK
:::. ::.::::::..:..::.::..:. :
XP_016 SKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVLGIELKQQKAVK
310 320 330 340 350 360
40 50 60 70 80 90
pF1KE2 VKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKV
.: .:.:.: ::::.::. :..: ::...::..::.. ..:: :::.::..:. : . ..
XP_016 IKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRI
370 380 390 400 410 420
100 110 120 130 140 150
pF1KE2 KQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHV
:. .::.::: :.:... ...:: .:: :.:::: :. :::. :: .... :
XP_016 KNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAFQAVQNL-PTK
430 440 450 460 470 480
160 170 180 190 200
pF1KE2 KVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRS-
: :.:::.:.:. :::::::. .::. :...:: :. ::.:.. :.. :::::::. ..
XP_016 KQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNLFMCHAL
490 500 510 520 530 540
210 220 230 240 250 260
pF1KE2 --KHSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRK
: :. .:...: .:. ..:..::::.:: .:.:...:::..: . ::. ...:
XP_016 GLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENH--KKDKRAMKK
550 560 570 580 590 600
270 280 290 300 310 320
pF1KE2 LLRRKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAK
::.. . .::
XP_016 LLKKMAYDREKYEKQDKSTNDWGCPDSQERRSFFV
610 620 630
>>XP_024309638 (OMIM: 613299) protein FAM13A isoform X17 (584 aa)
initn: 231 init1: 114 opt: 310 Z-score: 353.4 bits: 74.8 E(91774): 6.5e-13
Smith-Waterman score: 316; 29.6% identity (56.1% similar) in 287 aa overlap (38-321:40-309)
10 20 30 40 50 60
pF1KE2 SLIELTAFFDAFGIQLKRNKTEKVKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFF
.::: : : .:. .: :. ..
XP_024 QSKAAVRLKEDMKKIVAVPLNEQKDFTYQKLFGVSLQEL---ERQGLTENGIPAVVWNIV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 EKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAAVMLKAFFREL
: . . :: .::.::..: . :.: : .... .. : .: :: .:: :.:::
XP_024 EYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVC--SAASLLKLFLREL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANES
: ::. : ::.:.. : . :: ..:. .. :::.. . : :..:: ..
XP_024 PDSLITSALQPRFIQLFQDGRN-DVQESSLRDLIKELPDTHYCLLKYLCQFLTKVAKHHV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KNRMSLWNISTVMAPNLFFSRSKHSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQ
.:::.. :..::..:: : ..: : : .:. .:. . :..: .
XP_024 QNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCN---KIMAKILENYNTLFEVEYTENDH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 VRRMNEATMLLKKQLPSVRKL--LRRKTLERETASPKTSKVLQKSPSARRMSDVPEGVIR
.: : : ... :.. .: : . :::. .: . . :: : :: :.
XP_024 LRCENLARLIIVKEVYYKNSLPILLTRGLERDMPKPPPKTKIPKSRS--------EGSIQ
250 260 270 280 290
310 320 330 340 350 360
pF1KE2 VHAPLLSKVSMAI-QLNNQTKAKDILAKFQYENSHGSSECIKIQNQRLYEIGGNIGEHCL
.: : ..: .: ::.
XP_024 AHRVLQPELSDGIPQLSLRLSYRKACLEDMNSAEGAISAKLVPSSQEDERPLSPFYLSAH
300 310 320 330 340 350
>>XP_024308768 (OMIM: 610578) rho GTPase-activating prot (241 aa)
initn: 261 init1: 148 opt: 303 Z-score: 351.3 bits: 73.1 E(91774): 8.5e-13
Smith-Waterman score: 303; 29.2% identity (63.9% similar) in 216 aa overlap (27-237:32-236)
10 20 30 40 50
pF1KE2 MKKIRHLSLIELTAFFDAFGIQLKRNKTEKVKG--RDNGIFGVPLTVLLDGDRKKD
:: . :: .:. ::: : . . . .
XP_024 FRLHHSASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQ-IFGSHLHKVCERENST-
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 PGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYRE--ELDAKFNADKFKWDKMC
:: ... .: ::. ::. .::.:.:: : ... : . . :.: : .:. .
XP_024 ----VPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIH
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 HREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVMALPDANRDAA
.: :: :::::: ::: .. :. ... . .....:.. .:. :: :::.
XP_024 VVTGA--LKMFFRELPEPLFPYSFFEQFVEAIKKQDN-NTRIEAVKSLVQKLPPPNRDTM
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 QALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYE-ELLLANTAAHIIRLML
..:. ..:..:. ::: :: ... :..:.:. .... ... ... : :.. ..
XP_024 KVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAEL--MLS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 KYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLRRKTLERETASPKTSKVLQKSP
.:.::.
XP_024 EYSKIFGSEED
240
390 residues in 1 query sequences
64092750 residues in 91774 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Jul 16 15:59:07 2019 done: Tue Jul 16 15:59:08 2019
Total Scan time: 3.660 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]