Result of FASTA (omim) for
pF1KE2646
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2646, 2249 aa
1>>>pF1KE2646 2249 - 2249 aa - 2249 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 16.3183+/-0.00051; mu= -23.2290+/- 0.032
mean_var=791.6803+/-165.523, 0's: 0 Z-trim(124.7): 269 B-trim: 370 in 1/58
Lambda= 0.045583
statistics sampled from 46624 (46944) to 46624 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.781), E-opt: 0.2 (0.55), width: 16
Scan time: 26.390
The best scores are: opt bits E(85289)
NP_065783 (OMIM: 135900,614556,614562) AT-rich int (2249) 15624 1044.7 0
XP_016866596 (OMIM: 135900,614556,614562) PREDICTE (2256) 13899 931.2 0
NP_059989 (OMIM: 135900,614556,614562) AT-rich int (2236) 12103 813.1 0
XP_016866595 (OMIM: 135900,614556,614562) PREDICTE (2263) 11487 772.6 0
XP_016866594 (OMIM: 135900,614556,614562) PREDICTE (2306) 9284 627.8 4.7e-178
XP_005267126 (OMIM: 135900,614556,614562) PREDICTE (2289) 8761 593.4 1.1e-167
XP_016866593 (OMIM: 135900,614556,614562) PREDICTE (2316) 8705 589.7 1.4e-166
XP_011534286 (OMIM: 135900,614556,614562) PREDICTE (2359) 8663 586.9 9.4e-166
XP_016866592 (OMIM: 135900,614556,614562) PREDICTE (2326) 8622 584.2 6e-165
XP_016866598 (OMIM: 135900,614556,614562) PREDICTE (1539) 8433 571.6 2.5e-161
XP_011534290 (OMIM: 135900,614556,614562) PREDICTE (1336) 8294 562.4 1.2e-158
XP_016866597 (OMIM: 135900,614556,614562) PREDICTE (1551) 5028 347.7 6.3e-94
NP_006006 (OMIM: 603024,614607) AT-rich interactiv (2285) 3736 262.9 3.2e-68
NP_624361 (OMIM: 603024,614607) AT-rich interactiv (2068) 3359 238.1 8.5e-61
NP_000081 (OMIM: 120180,130020,130050) collagen al (1466) 634 58.7 5.8e-07
NP_000079 (OMIM: 114000,120150,130000,130060,16620 (1464) 588 55.7 4.7e-06
NP_001836 (OMIM: 120130,175780,180000,607595,61177 (1669) 563 54.1 1.6e-05
XP_011519350 (OMIM: 120130,175780,180000,607595,61 (1605) 561 54.0 1.7e-05
XP_011508860 (OMIM: 120131,203780) PREDICTED: coll (1654) 552 53.4 2.7e-05
XP_011522643 (OMIM: 114000,120150,130000,130060,16 (1398) 538 52.4 4.5e-05
XP_011536691 (OMIM: 601234) PREDICTED: nascent pol (2078) 509 50.7 0.00023
XP_006719477 (OMIM: 601234) PREDICTED: nascent pol (2082) 509 50.7 0.00023
XP_006719475 (OMIM: 601234) PREDICTED: nascent pol (2082) 509 50.7 0.00023
XP_006719476 (OMIM: 601234) PREDICTED: nascent pol (2082) 509 50.7 0.00023
XP_016858786 (OMIM: 120131,203780) PREDICTED: coll (1651) 471 48.1 0.0011
XP_011526344 (OMIM: 120216) PREDICTED: collagen al (1744) 463 47.6 0.0016
NP_056534 (OMIM: 120216) collagen alpha-3(V) chain (1745) 463 47.6 0.0016
XP_005246334 (OMIM: 104200,120070,141200,203780) P (1635) 460 47.3 0.0018
NP_511040 (OMIM: 120210,614134,614135) collagen al ( 678) 445 46.0 0.0018
XP_016869755 (OMIM: 120215,130000) PREDICTED: coll (1715) 459 47.3 0.0019
NP_001265003 (OMIM: 120215,130000) collagen alpha- (1838) 459 47.3 0.002
NP_000084 (OMIM: 120215,130000) collagen alpha-1(V (1838) 459 47.3 0.002
XP_011517445 (OMIM: 608461,615155) PREDICTED: coll (1353) 453 46.8 0.0021
NP_001842 (OMIM: 120210,614134,614135) collagen al ( 921) 446 46.2 0.0022
NP_057232 (OMIM: 604999) SH3 and multiple ankyrin (2161) 459 47.4 0.0023
XP_006723296 (OMIM: 604999) PREDICTED: SH3 and mul (2161) 459 47.4 0.0023
XP_011525315 (OMIM: 604999) PREDICTED: SH3 and mul (2169) 459 47.4 0.0023
XP_016865740 (OMIM: 120290,184840,215150,277610,60 (1342) 450 46.6 0.0024
XP_011512604 (OMIM: 120290,184840,215150,277610,60 (1365) 450 46.6 0.0024
XP_011517446 (OMIM: 608461,615155) PREDICTED: coll (1352) 449 46.5 0.0025
XP_011512602 (OMIM: 120290,184840,215150,277610,60 (1438) 450 46.6 0.0025
XP_011512601 (OMIM: 120290,184840,215150,277610,60 (1498) 450 46.7 0.0026
XP_011508859 (OMIM: 120131,203780) PREDICTED: coll (1663) 451 46.8 0.0027
NP_542410 (OMIM: 120290,184840,215150,277610,60186 (1629) 450 46.7 0.0028
NP_542412 (OMIM: 120290,184840,215150,277610,60186 (1650) 450 46.7 0.0028
NP_542411 (OMIM: 120290,184840,215150,277610,60186 (1736) 450 46.7 0.0029
XP_016865739 (OMIM: 120290,184840,215150,277610,60 (1736) 450 46.7 0.0029
XP_011517440 (OMIM: 608461,615155) PREDICTED: coll (1858) 450 46.7 0.0031
NP_116277 (OMIM: 608461,615155) collagen alpha-1(X (1860) 450 46.7 0.0031
XP_016874320 (OMIM: 108300,120140,132450,150600,15 (1305) 431 45.4 0.0056
>>NP_065783 (OMIM: 135900,614556,614562) AT-rich interac (2249 aa)
initn: 15624 init1: 15624 opt: 15624 Z-score: 5571.0 bits: 1044.7 E(85289): 0
Smith-Waterman score: 15624; 100.0% identity (100.0% similar) in 2249 aa overlap (1-2249:1-2249)
10 20 30 40 50 60
pF1KE2 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 KPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPF
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 LSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTY
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 GPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 SAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 ESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFM
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 EERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 LKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 NSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPY
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 QQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSN
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 LGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMY
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 GPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQT
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 HGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 HGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMM
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 VPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQ
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 RSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVL
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 KQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFL
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 ELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDD
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 DEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVV
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 DRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQE
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 GKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLE
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 DEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLIL
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 LHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAY
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 TESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLIL
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 ATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLI
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 SFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEG
2170 2180 2190 2200 2210 2220
2230 2240
pF1KE2 RLLDISISAVLNSLVASVICDVLFQIGQL
:::::::::::::::::::::::::::::
NP_065 RLLDISISAVLNSLVASVICDVLFQIGQL
2230 2240
>>XP_016866596 (OMIM: 135900,614556,614562) PREDICTED: A (2256 aa)
initn: 8413 init1: 8413 opt: 13899 Z-score: 4957.9 bits: 931.2 E(85289): 0
Smith-Waterman score: 14907; 94.5% identity (94.5% similar) in 2316 aa overlap (1-2249:1-2256)
10 20 30 40 50 60
pF1KE2 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG
610 620 630 640 650 660
670 680 690 700
pF1KE2 KPNHEDLNLIQQERPSSLP--------------DLSGSIDDLPTGTEATLSSAVSASGST
::::::::::::::::::: :::::::::::::::::::::::::::
XP_016 KPNHEDLNLIQQERPSSLPVEVLASEDAAFGLKDLSGSIDDLPTGTEATLSSAVSASGST
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE2 SSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPP
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE2 QPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHA
:::::::::::::::::::::::::
XP_016 QPPGSQSESSSHPALSQSPMPQERG-----------------------------------
790 800
830 840 850 860 870 880
pF1KE2 GISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQG
:::::::::::::::::::::::::::::::::::
XP_016 -------------------------NYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQG
810 820 830 840
890 900 910 920 930 940
pF1KE2 PSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAA
850 860 870 880 890 900
950 960 970 980 990 1000
pF1KE2 AAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNS
910 920 930 940 950 960
1010 1020 1030 1040
pF1KE2 SAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSK---------------------
:::::::::::::::::::::::::::::::::::::::
XP_016 SAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPS
970 980 990 1000 1010 1020
1050 1060 1070
pF1KE2 --------------------------------KSSSSTTTGEKITKVYELGNEPERKLWV
::::::::::::::::::::::::::::
XP_016 PMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWV
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE2 DRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGT
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE2 SSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQ
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE2 TPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNS
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE2 MTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQS
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE2 PSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYK
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE2 RHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQ
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE2 GPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGM
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE2 NRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRA
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE2 PSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSV
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE2 EASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNL
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE2 SQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEE
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770 1780 1790
pF1KE2 DAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVK
1750 1760 1770 1780 1790 1800
1800 1810 1820 1830 1840 1850
pF1KE2 KNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSA
1810 1820 1830 1840 1850 1860
1860 1870 1880 1890 1900 1910
pF1KE2 GRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSH
1870 1880 1890 1900 1910 1920
1920 1930 1940 1950 1960 1970
pF1KE2 RNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVL
1930 1940 1950 1960 1970 1980
1980 1990 2000 2010 2020 2030
pF1KE2 ILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISG
1990 2000 2010 2020 2030 2040
2040 2050 2060 2070 2080 2090
pF1KE2 QLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQD
2050 2060 2070 2080 2090 2100
2100 2110 2120 2130 2140 2150
pF1KE2 NNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQK
2110 2120 2130 2140 2150 2160
2160 2170 2180 2190 2200 2210
pF1KE2 GSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRS
2170 2180 2190 2200 2210 2220
2220 2230 2240
pF1KE2 EFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
::::::::::::::::::::::::::::::::::::
XP_016 EFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
2230 2240 2250
>>NP_059989 (OMIM: 135900,614556,614562) AT-rich interac (2236 aa)
initn: 11473 init1: 11473 opt: 12103 Z-score: 4319.7 bits: 813.1 E(85289): 0
Smith-Waterman score: 15489; 99.4% identity (99.4% similar) in 2249 aa overlap (1-2249:1-2236)
10 20 30 40 50 60
pF1KE2 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ
::::::::::::::::::::::::::::::::::::::: ::::::::
NP_059 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQ-------------MPPQYGQQ
550 560 570 580
610 620 630 640 650 660
pF1KE2 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE2 KPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 KPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPF
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE2 SPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 SPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPA
710 720 730 740 750 760
790 800 810 820 830 840
pF1KE2 LSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 LSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTY
770 780 790 800 810 820
850 860 870 880 890 900
pF1KE2 GPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 GPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMP
830 840 850 860 870 880
910 920 930 940 950 960
pF1KE2 SAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 SAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR
890 900 910 920 930 940
970 980 990 1000 1010 1020
pF1KE2 QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPG
950 960 970 980 990 1000
1030 1040 1050 1060 1070 1080
pF1KE2 ESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 ESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFM
1010 1020 1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KE2 EERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 EERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASS
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KE2 LKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 LKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGS
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KE2 NSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 NSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPY
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KE2 QQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 QQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSN
1250 1260 1270 1280 1290 1300
1330 1340 1350 1360 1370 1380
pF1KE2 LGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 LGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMY
1310 1320 1330 1340 1350 1360
1390 1400 1410 1420 1430 1440
pF1KE2 GPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 GPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQT
1370 1380 1390 1400 1410 1420
1450 1460 1470 1480 1490 1500
pF1KE2 HGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 HGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMM
1430 1440 1450 1460 1470 1480
1510 1520 1530 1540 1550 1560
pF1KE2 VPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 VPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQ
1490 1500 1510 1520 1530 1540
1570 1580 1590 1600 1610 1620
pF1KE2 RSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 RSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVL
1550 1560 1570 1580 1590 1600
1630 1640 1650 1660 1670 1680
pF1KE2 KQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 KQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFL
1610 1620 1630 1640 1650 1660
1690 1700 1710 1720 1730 1740
pF1KE2 ELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 ELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDD
1670 1680 1690 1700 1710 1720
1750 1760 1770 1780 1790 1800
pF1KE2 DEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 DEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVV
1730 1740 1750 1760 1770 1780
1810 1820 1830 1840 1850 1860
pF1KE2 DRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 DRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQE
1790 1800 1810 1820 1830 1840
1870 1880 1890 1900 1910 1920
pF1KE2 GKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 GKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLE
1850 1860 1870 1880 1890 1900
1930 1940 1950 1960 1970 1980
pF1KE2 DEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 DEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLIL
1910 1920 1930 1940 1950 1960
1990 2000 2010 2020 2030 2040
pF1KE2 LHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 LHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAY
1970 1980 1990 2000 2010 2020
2050 2060 2070 2080 2090 2100
pF1KE2 TESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 TESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLIL
2030 2040 2050 2060 2070 2080
2110 2120 2130 2140 2150 2160
pF1KE2 ATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 ATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLI
2090 2100 2110 2120 2130 2140
2170 2180 2190 2200 2210 2220
pF1KE2 SFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 SFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEG
2150 2160 2170 2180 2190 2200
2230 2240
pF1KE2 RLLDISISAVLNSLVASVICDVLFQIGQL
:::::::::::::::::::::::::::::
NP_059 RLLDISISAVLNSLVASVICDVLFQIGQL
2210 2220 2230
>>XP_016866595 (OMIM: 135900,614556,614562) PREDICTED: A (2263 aa)
initn: 10804 init1: 10804 opt: 11487 Z-score: 4100.7 bits: 772.6 E(85289): 0
Smith-Waterman score: 15586; 99.4% identity (99.4% similar) in 2263 aa overlap (1-2249:1-2263)
10 20 30 40 50 60
pF1KE2 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG
610 620 630 640 650 660
670 680 690 700
pF1KE2 KPNHEDLNLIQQERPSSLP--------------DLSGSIDDLPTGTEATLSSAVSASGST
::::::::::::::::::: :::::::::::::::::::::::::::
XP_016 KPNHEDLNLIQQERPSSLPVEVLASEDAAFGLKDLSGSIDDLPTGTEATLSSAVSASGST
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE2 SSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPP
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE2 QPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHA
790 800 810 820 830 840
830 840 850 860 870 880
pF1KE2 GISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQG
850 860 870 880 890 900
890 900 910 920 930 940
pF1KE2 PSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAA
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KE2 AAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNS
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KE2 SAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNE
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KE2 PERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELA
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KE2 TNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANS
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KE2 GSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDS
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KE2 SFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSM
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KE2 QDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLY
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KE2 PQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYP
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KE2 YSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQ
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KE2 APPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSL
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KE2 PNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREI
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KE2 TFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDS
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KE2 TVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLAD
1690 1700 1710 1720 1730 1740
1730 1740 1750 1760 1770 1780
pF1KE2 DSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDK
1750 1760 1770 1780 1790 1800
1790 1800 1810 1820 1830 1840
pF1KE2 LPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRP
1810 1820 1830 1840 1850 1860
1850 1860 1870 1880 1890 1900
pF1KE2 PPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFG
1870 1880 1890 1900 1910 1920
1910 1920 1930 1940 1950 1960
pF1KE2 IQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMS
1930 1940 1950 1960 1970 1980
1970 1980 1990 2000 2010 2020
pF1KE2 KHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLV
1990 2000 2010 2020 2030 2040
2030 2040 2050 2060 2070 2080
pF1KE2 TLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETL
2050 2060 2070 2080 2090 2100
2090 2100 2110 2120 2130 2140
pF1KE2 CKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAA
2110 2120 2130 2140 2150 2160
2150 2160 2170 2180 2190 2200
pF1KE2 RAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMA
2170 2180 2190 2200 2210 2220
2210 2220 2230 2240
pF1KE2 RVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
:::::::::::::::::::::::::::::::::::::::::::
XP_016 RVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
2230 2240 2250 2260
>>XP_016866594 (OMIM: 135900,614556,614562) PREDICTED: A (2306 aa)
initn: 13651 init1: 8821 opt: 9284 Z-score: 3317.6 bits: 627.8 E(85289): 4.7e-178
Smith-Waterman score: 15337; 97.5% identity (97.5% similar) in 2281 aa overlap (26-2249:26-2306)
10 20 30 40 50 60
pF1KE2 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME
:::::::::::::::::::::::::::::::::::
XP_016 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG
610 620 630 640 650 660
670 680 690 700
pF1KE2 KPNHEDLNLIQQERPSSLP--------------DLSGSIDDLPTGTEATLSSAVSASGST
::::::::::::::::::: :::::::::::::::::::::::::::
XP_016 KPNHEDLNLIQQERPSSLPVEVLASEDAAFGLKDLSGSIDDLPTGTEATLSSAVSASGST
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE2 SSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPP
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE2 QPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHA
790 800 810 820 830 840
830 840 850 860 870 880
pF1KE2 GISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQG
850 860 870 880 890 900
890 900 910 920 930 940
pF1KE2 PSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAA
910 920 930 940 950 960
950 960
pF1KE2 AAVMQAAANSAQSR-------------------------------------------QGS
:::::::::::::: :::
XP_016 AAVMQAAANSAQSRPPYIRSPAYPSQSGAGGRPMFSSQHPNYGNSQAPMVHQPDQYGQGS
970 980 990 1000 1010 1020
970 980 990 1000 1010 1020
pF1KE2 FPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESK
1030 1040 1050 1060 1070 1080
1030 1040 1050 1060 1070 1080
pF1KE2 LPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEER
1090 1100 1110 1120 1130 1140
1090 1100 1110 1120 1130 1140
pF1KE2 GSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKK
1150 1160 1170 1180 1190 1200
1150 1160 1170 1180 1190 1200
pF1KE2 QYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSM
1210 1220 1230 1240 1250 1260
1210 1220 1230 1240 1250 1260
pF1KE2 AEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQG
1270 1280 1290 1300 1310 1320
1270 1280 1290 1300 1310 1320
pF1KE2 MSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGM
1330 1340 1350 1360 1370 1380
1330 1340 1350 1360 1370 1380
pF1KE2 GQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPP
1390 1400 1410 1420 1430 1440
1390 1400 1410 1420 1430 1440
pF1KE2 AKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGI
1450 1460 1470 1480 1490 1500
1450 1460 1470 1480 1490 1500
pF1KE2 PPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPD
1510 1520 1530 1540 1550 1560
1510 1520 1530 1540 1550 1560
pF1KE2 QRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSL
1570 1580 1590 1600 1610 1620
1570 1580 1590 1600 1610 1620
pF1KE2 ENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQR
1630 1640 1650 1660 1670 1680
1630 1640 1650 1660 1670 1680
pF1KE2 RKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELL
1690 1700 1710 1720 1730 1740
1690 1700 1710 1720 1730 1740
pF1KE2 VEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEE
1750 1760 1770 1780 1790 1800
1750 1760 1770 1780 1790 1800
pF1KE2 DEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRS
1810 1820 1830 1840 1850 1860
1810 1820 1830 1840 1850 1860
pF1KE2 DKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKG
1870 1880 1890 1900 1910 1920
1870 1880 1890 1900 1910 1920
pF1KE2 DSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEP
1930 1940 1950 1960 1970 1980
1930 1940 1950 1960 1970 1980
pF1KE2 RSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHH
1990 2000 2010 2020 2030 2040
1990 2000 2010 2020 2030 2040
pF1KE2 EHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTES
2050 2060 2070 2080 2090 2100
2050 2060 2070 2080 2090 2100
pF1KE2 ICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATP
2110 2120 2130 2140 2150 2160
2110 2120 2130 2140 2150 2160
pF1KE2 PFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFL
2170 2180 2190 2200 2210 2220
2170 2180 2190 2200 2210 2220
pF1KE2 EDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLL
2230 2240 2250 2260 2270 2280
2230 2240
pF1KE2 DISISAVLNSLVASVICDVLFQIGQL
::::::::::::::::::::::::::
XP_016 DISISAVLNSLVASVICDVLFQIGQL
2290 2300
>>XP_005267126 (OMIM: 135900,614556,614562) PREDICTED: A (2289 aa)
initn: 12352 init1: 8264 opt: 8761 Z-score: 3131.8 bits: 593.4 E(85289): 1.1e-167
Smith-Waterman score: 15321; 97.1% identity (97.1% similar) in 2294 aa overlap (9-2249:9-2289)
10 20 30 40 50 60
pF1KE2 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAME
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQ
::::::::::::::::::::::::::::::::::::::: ::::::::
XP_005 QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQ-------------MPPQYGQQ
550 560 570 580
610 620 630 640 650 660
pF1KE2 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPG
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE2 KPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPF
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE2 SPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPA
710 720 730 740 750 760
790 800 810 820 830 840
pF1KE2 LSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTY
770 780 790 800 810 820
850 860 870 880 890 900
pF1KE2 GPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMP
830 840 850 860 870 880
910 920 930 940 950 960
pF1KE2 SAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR
890 900 910 920 930 940
970 980 990 1000 1010 1020
pF1KE2 QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPG
950 960 970 980 990 1000
1030 1040
pF1KE2 ESKLPLPLKADGKEEGTPQPESKSK-----------------------------------
:::::::::::::::::::::::::
XP_005 ESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHG
1010 1020 1030 1040 1050 1060
1050 1060 1070 1080
pF1KE2 ------------------KSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPV
::::::::::::::::::::::::::::::::::::::::::
XP_005 DESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPV
1070 1080 1090 1100 1110 1120
1090 1100 1110 1120 1130 1140
pF1KE2 SSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQ
1130 1140 1150 1160 1170 1180
1150 1160 1170 1180 1190 1200
pF1KE2 YLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVP
1190 1200 1210 1220 1230 1240
1210 1220 1230 1240 1250 1260
pF1KE2 GDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMP
1250 1260 1270 1280 1290 1300
1270 1280 1290 1300 1310 1320
pF1KE2 DVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQ
1310 1320 1330 1340 1350 1360
1330 1340 1350 1360 1370 1380
pF1KE2 QFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRH
1370 1380 1390 1400 1410 1420
1390 1400 1410 1420 1430 1440
pF1KE2 EGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQM
1430 1440 1450 1460 1470 1480
1450 1460 1470 1480 1490 1500
pF1KE2 MGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRIN
1490 1500 1510 1520 1530 1540
1510 1520 1530 1540 1550 1560
pF1KE2 HESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRM
1550 1560 1570 1580 1590 1600
1570 1580 1590 1600 1610 1620
pF1KE2 SPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKIT
1610 1620 1630 1640 1650 1660
1630 1640 1650 1660 1670 1680
pF1KE2 SKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYF
1670 1680 1690 1700 1710 1720
1690 1700 1710 1720 1730 1740
pF1KE2 RKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEED
1730 1740 1750 1760 1770 1780
1750 1760 1770 1780 1790 1800
pF1KE2 EEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLG
1790 1800 1810 1820 1830 1840
1810 1820 1830 1840 1850 1860
pF1KE2 RVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEE
1850 1860 1870 1880 1890 1900
1870 1880 1890 1900 1910 1920
pF1KE2 QQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRD
1910 1920 1930 1940 1950 1960
1930 1940 1950 1960 1970 1980
pF1KE2 ETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPE
1970 1980 1990 2000 2010 2020
1990 2000 2010 2020 2030 2040
pF1KE2 RKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLP
2030 2040 2050 2060 2070 2080
2050 2060 2070 2080 2090 2100
pF1KE2 ILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSR
2090 2100 2110 2120 2130 2140
2110 2120 2130 2140 2150 2160
pF1KE2 QEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGV
2150 2160 2170 2180 2190 2200
2170 2180 2190 2200 2210 2220
pF1KE2 TMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISI
2210 2220 2230 2240 2250 2260
2230 2240
pF1KE2 SAVLNSLVASVICDVLFQIGQL
::::::::::::::::::::::
XP_005 SAVLNSLVASVICDVLFQIGQL
2270 2280
>>XP_016866593 (OMIM: 135900,614556,614562) PREDICTED: A (2316 aa)
initn: 13094 init1: 8264 opt: 8705 Z-score: 3111.8 bits: 589.7 E(85289): 1.4e-166
Smith-Waterman score: 15259; 97.1% identity (97.1% similar) in 2281 aa overlap (36-2249:36-2316)
10 20 30 40 50 60
pF1KE2 GAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLP
::::::::::::::::::::::::::::::
XP_016 GAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 AGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 GVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 PSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 PGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGY
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 CQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHE
610 620 630 640 650 660
670 680 690 700 710
pF1KE2 DLNLIQQERPSSLP--------------DLSGSIDDLPTGTEATLSSAVSASGSTSSQGD
:::::::::::::: ::::::::::::::::::::::::::::::::
XP_016 DLNLIQQERPSSLPVEVLASEDAAFGLKDLSGSIDDLPTGTEATLSSAVSASGSTSSQGD
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE2 QSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGS
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE2 QSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSF
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE2 QQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPC
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE2 GAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQ
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE2 AAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASV
970 980 990 1000 1010 1020
1020 1030 1040
pF1KE2 GLADMMSPGESKLPLPLKADGKEEGTPQPESKSK--------------------------
::::::::::::::::::::::::::::::::::
XP_016 GLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPS
1030 1040 1050 1060 1070 1080
1050 1060 1070
pF1KE2 ---------------------------KSSSSTTTGEKITKVYELGNEPERKLWVDRYLT
:::::::::::::::::::::::::::::::::
XP_016 SASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLT
1090 1100 1110 1120 1130 1140
1080 1090 1100 1110 1120 1130
pF1KE2 FMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAA
1150 1160 1170 1180 1190 1200
1140 1150 1160 1170 1180 1190
pF1KE2 SSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQST
1210 1220 1230 1240 1250 1260
1200 1210 1220 1230 1240 1250
pF1KE2 GSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNA
1270 1280 1290 1300 1310 1320
1260 1270 1280 1290 1300 1310
pF1KE2 PYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAM
1330 1340 1350 1360 1370 1380
1320 1330 1340 1350 1360 1370
pF1KE2 SNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDG
1390 1400 1410 1420 1430 1440
1380 1390 1400 1410 1420 1430
pF1KE2 MYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQI
1450 1460 1470 1480 1490 1500
1440 1450 1460 1470 1480 1490
pF1KE2 QTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDD
1510 1520 1530 1540 1550 1560
1500 1510 1520 1530 1540 1550
pF1KE2 MMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS
1570 1580 1590 1600 1610 1620
1560 1570 1580 1590 1600 1610
pF1KE2 FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQP
1630 1640 1650 1660 1670 1680
1620 1630 1640 1650 1660 1670
pF1KE2 VLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSG
1690 1700 1710 1720 1730 1740
1680 1690 1700 1710 1720 1730
pF1KE2 FLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECI
1750 1760 1770 1780 1790 1800
1740 1750 1760 1770 1780 1790
pF1KE2 DDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLF
1810 1820 1830 1840 1850 1860
1800 1810 1820 1830 1840 1850
pF1KE2 VVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKE
1870 1880 1890 1900 1910 1920
1860 1870 1880 1890 1900 1910
pF1KE2 QEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKL
1930 1940 1950 1960 1970 1980
1920 1930 1940 1950 1960 1970
pF1KE2 LEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKL
1990 2000 2010 2020 2030 2040
1980 1990 2000 2010 2020 2030
pF1KE2 ILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLS
2050 2060 2070 2080 2090 2100
2040 2050 2060 2070 2080 2090
pF1KE2 AYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDL
2110 2120 2130 2140 2150 2160
2100 2110 2120 2130 2140 2150
pF1KE2 ILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGN
2170 2180 2190 2200 2210 2220
2160 2170 2180 2190 2200 2210
pF1KE2 LISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLH
2230 2240 2250 2260 2270 2280
2220 2230 2240
pF1KE2 EGRLLDISISAVLNSLVASVICDVLFQIGQL
:::::::::::::::::::::::::::::::
XP_016 EGRLLDISISAVLNSLVASVICDVLFQIGQL
2290 2300 2310
>>XP_011534286 (OMIM: 135900,614556,614562) PREDICTED: A (2359 aa)
initn: 13094 init1: 8264 opt: 8663 Z-score: 3096.8 bits: 586.9 E(85289): 9.4e-166
Smith-Waterman score: 14908; 95.2% identity (95.2% similar) in 2281 aa overlap (79-2249:79-2359)
50 60 70 80 90 100
pF1KE2 SSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQ
::::::::::::::::::::::::::::::
XP_011 SSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQ
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE2 QLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAG
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE2 GQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVP
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE2 EFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHE
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE2 GYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAA
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE2 AAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQ
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE2 NQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQ
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE2 AAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQL
470 480 490 500 510 520
530 540 550 560 570 580
pF1KE2 YGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKE
530 540 550 560 570 580
590 600 610 620 630 640
pF1KE2 TFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEG
590 600 610 620 630 640
650 660 670 680 690
pF1KE2 YGTRSQPPLAPGKPNHEDLNLIQQERPSSLP--------------DLSGSIDDLPTGTEA
::::::::::::::::::::::::::::::: :::::::::::::::
XP_011 YGTRSQPPLAPGKPNHEDLNLIQQERPSSLPVEVLASEDAAFGLKDLSGSIDDLPTGTEA
650 660 670 680 690 700
700 710 720 730 740 750
pF1KE2 TLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPI
710 720 730 740 750 760
760 770 780 790 800 810
pF1KE2 SPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSM
770 780 790 800 810 820
820 830 840 850 860 870
pF1KE2 SPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGM
830 840 850 860 870 880
880 890 900 910 920 930
pF1KE2 GISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPP
890 900 910 920 930 940
940 950 960
pF1KE2 MPTVNRKAQEAAAAVMQAAANSAQSR----------------------------------
::::::::::::::::::::::::::
XP_011 MPTVNRKAQEAAAAVMQAAANSAQSRPPYIRSPAYPSQSGAGGRPMFSSQHPNYGNSQAP
950 960 970 980 990 1000
970 980 990 1000 1010
pF1KE2 ---------QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASV
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVHQPDQYGQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASV
1010 1020 1030 1040 1050 1060
1020 1030 1040
pF1KE2 GLADMMSPGESKLPLPLKADGKEEGTPQPESKSK--------------------------
::::::::::::::::::::::::::::::::::
XP_011 GLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPS
1070 1080 1090 1100 1110 1120
1050 1060 1070
pF1KE2 ---------------------------KSSSSTTTGEKITKVYELGNEPERKLWVDRYLT
:::::::::::::::::::::::::::::::::
XP_011 SASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLT
1130 1140 1150 1160 1170 1180
1080 1090 1100 1110 1120 1130
pF1KE2 FMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAA
1190 1200 1210 1220 1230 1240
1140 1150 1160 1170 1180 1190
pF1KE2 SSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQST
1250 1260 1270 1280 1290 1300
1200 1210 1220 1230 1240 1250
pF1KE2 GSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNA
1310 1320 1330 1340 1350 1360
1260 1270 1280 1290 1300 1310
pF1KE2 PYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAM
1370 1380 1390 1400 1410 1420
1320 1330 1340 1350 1360 1370
pF1KE2 SNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDG
1430 1440 1450 1460 1470 1480
1380 1390 1400 1410 1420 1430
pF1KE2 MYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQI
1490 1500 1510 1520 1530 1540
1440 1450 1460 1470 1480 1490
pF1KE2 QTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDD
1550 1560 1570 1580 1590 1600
1500 1510 1520 1530 1540 1550
pF1KE2 MMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS
1610 1620 1630 1640 1650 1660
1560 1570 1580 1590 1600 1610
pF1KE2 FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQP
1670 1680 1690 1700 1710 1720
1620 1630 1640 1650 1660 1670
pF1KE2 VLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSG
1730 1740 1750 1760 1770 1780
1680 1690 1700 1710 1720 1730
pF1KE2 FLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECI
1790 1800 1810 1820 1830 1840
1740 1750 1760 1770 1780 1790
pF1KE2 DDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLF
1850 1860 1870 1880 1890 1900
1800 1810 1820 1830 1840 1850
pF1KE2 VVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKE
1910 1920 1930 1940 1950 1960
1860 1870 1880 1890 1900 1910
pF1KE2 QEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKL
1970 1980 1990 2000 2010 2020
1920 1930 1940 1950 1960 1970
pF1KE2 LEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKL
2030 2040 2050 2060 2070 2080
1980 1990 2000 2010 2020 2030
pF1KE2 ILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLS
2090 2100 2110 2120 2130 2140
2040 2050 2060 2070 2080 2090
pF1KE2 AYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDL
2150 2160 2170 2180 2190 2200
2100 2110 2120 2130 2140 2150
pF1KE2 ILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGN
2210 2220 2230 2240 2250 2260
2160 2170 2180 2190 2200 2210
pF1KE2 LISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLH
2270 2280 2290 2300 2310 2320
2220 2230 2240
pF1KE2 EGRLLDISISAVLNSLVASVICDVLFQIGQL
:::::::::::::::::::::::::::::::
XP_011 EGRLLDISISAVLNSLVASVICDVLFQIGQL
2330 2340 2350
>>XP_016866592 (OMIM: 135900,614556,614562) PREDICTED: A (2326 aa)
initn: 13094 init1: 8264 opt: 8622 Z-score: 3082.3 bits: 584.2 E(85289): 6e-165
Smith-Waterman score: 15179; 96.6% identity (96.6% similar) in 2281 aa overlap (46-2249:46-2326)
20 30 40 50 60 70
pF1KE2 AKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEA
::::::::::::::::::::::::::::::
XP_016 AKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEA
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE2 PAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPIS
80 90 100 110 120 130
140 150 160 170 180 190
pF1KE2 NNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEP
140 150 160 170 180 190
200 210 220 230 240 250
pF1KE2 AGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQH
200 210 220 230 240 250
260 270 280 290 300 310
pF1KE2 GGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGG
260 270 280 290 300 310
320 330 340 350 360 370
pF1KE2 GGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQG
320 330 340 350 360 370
380 390 400 410 420 430
pF1KE2 GGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGG
380 390 400 410 420 430
440 450 460 470 480 490
pF1KE2 SYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQ
440 450 460 470 480 490
500 510 520 530 540 550
pF1KE2 RSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGP
500 510 520 530 540 550
560 570 580 590 600 610
pF1KE2 QRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYS
560 570 580 590 600 610
620 630 640 650 660 670
pF1KE2 QQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERP
620 630 640 650 660 670
680 690 700 710 720
pF1KE2 SSLP--------------DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFS
:::: ::::::::::::::::::::::::::::::::::::::::::
XP_016 SSLPVEVLASEDAAFGLKDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFS
680 690 700 710 720 730
730 740 750 760 770 780
pF1KE2 PHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPAL
740 750 760 770 780 790
790 800 810 820 830 840
pF1KE2 SQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYG
800 810 820 830 840 850
850 860 870 880 890 900
pF1KE2 PQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPS
860 870 880 890 900 910
910 920 930 940 950 960
pF1KE2 AGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR-
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRY
920 930 940 950 960 970
970 980 990 1000 1010
pF1KE2 ---------QGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASV
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATQEHAPGRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASV
980 990 1000 1010 1020 1030
1020 1030 1040
pF1KE2 GLADMMSPGESKLPLPLKADGKEEGTPQPESKSK--------------------------
::::::::::::::::::::::::::::::::::
XP_016 GLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPS
1040 1050 1060 1070 1080 1090
1050 1060 1070
pF1KE2 ---------------------------KSSSSTTTGEKITKVYELGNEPERKLWVDRYLT
:::::::::::::::::::::::::::::::::
XP_016 SASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLT
1100 1110 1120 1130 1140 1150
1080 1090 1100 1110 1120 1130
pF1KE2 FMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAA
1160 1170 1180 1190 1200 1210
1140 1150 1160 1170 1180 1190
pF1KE2 SSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQST
1220 1230 1240 1250 1260 1270
1200 1210 1220 1230 1240 1250
pF1KE2 GSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNA
1280 1290 1300 1310 1320 1330
1260 1270 1280 1290 1300 1310
pF1KE2 PYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAM
1340 1350 1360 1370 1380 1390
1320 1330 1340 1350 1360 1370
pF1KE2 SNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDG
1400 1410 1420 1430 1440 1450
1380 1390 1400 1410 1420 1430
pF1KE2 MYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQI
1460 1470 1480 1490 1500 1510
1440 1450 1460 1470 1480 1490
pF1KE2 QTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDD
1520 1530 1540 1550 1560 1570
1500 1510 1520 1530 1540 1550
pF1KE2 MMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS
1580 1590 1600 1610 1620 1630
1560 1570 1580 1590 1600 1610
pF1KE2 FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQP
1640 1650 1660 1670 1680 1690
1620 1630 1640 1650 1660 1670
pF1KE2 VLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSG
1700 1710 1720 1730 1740 1750
1680 1690 1700 1710 1720 1730
pF1KE2 FLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECI
1760 1770 1780 1790 1800 1810
1740 1750 1760 1770 1780 1790
pF1KE2 DDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLF
1820 1830 1840 1850 1860 1870
1800 1810 1820 1830 1840 1850
pF1KE2 VVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKE
1880 1890 1900 1910 1920 1930
1860 1870 1880 1890 1900 1910
pF1KE2 QEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKL
1940 1950 1960 1970 1980 1990
1920 1930 1940 1950 1960 1970
pF1KE2 LEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKL
2000 2010 2020 2030 2040 2050
1980 1990 2000 2010 2020 2030
pF1KE2 ILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLS
2060 2070 2080 2090 2100 2110
2040 2050 2060 2070 2080 2090
pF1KE2 AYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDL
2120 2130 2140 2150 2160 2170
2100 2110 2120 2130 2140 2150
pF1KE2 ILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGN
2180 2190 2200 2210 2220 2230
2160 2170 2180 2190 2200 2210
pF1KE2 LISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLH
2240 2250 2260 2270 2280 2290
2220 2230 2240
pF1KE2 EGRLLDISISAVLNSLVASVICDVLFQIGQL
:::::::::::::::::::::::::::::::
XP_016 EGRLLDISISAVLNSLVASVICDVLFQIGQL
2300 2310 2320
>>XP_016866598 (OMIM: 135900,614556,614562) PREDICTED: A (1539 aa)
initn: 8264 init1: 8264 opt: 8433 Z-score: 3017.5 bits: 571.6 E(85289): 2.5e-161
Smith-Waterman score: 10107; 96.6% identity (96.6% similar) in 1539 aa overlap (764-2249:1-1539)
740 750 760 770 780 790
pF1KE2 GPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFM
::::::::::::::::::::::::::::::
XP_016 MPPQPPGSQSESSSHPALSQSPMPQERGFM
10 20 30
800 810 820 830 840 850
pF1KE2 AGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNY
40 50 60 70 80 90
860 870 880 890 900 910
pF1KE2 SRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNM
100 110 120 130 140 150
920 930 940 950 960 970
pF1KE2 SSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLM
160 170 180 190 200 210
980 990 1000 1010 1020 1030
pF1KE2 ASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGK
220 230 240 250 260 270
1040
pF1KE2 EEGTPQPESKSK------------------------------------------------
::::::::::::
XP_016 EEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPK
280 290 300 310 320 330
1050 1060 1070 1080 1090 1100
pF1KE2 -----KSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDL
340 350 360 370 380 390
1110 1120 1130 1140 1150 1160
pF1KE2 FRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGE
400 410 420 430 440 450
1170 1180 1190 1200 1210 1220
pF1KE2 EPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPH
460 470 480 490 500 510
1230 1240 1250 1260 1270 1280
pF1KE2 GQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKD
520 530 540 550 560 570
1290 1300 1310 1320 1330 1340
pF1KE2 PFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHE
580 590 600 610 620 630
1350 1360 1370 1380 1390 1400
pF1KE2 PYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQ
640 650 660 670 680 690
1410 1420 1430 1440 1450 1460
pF1KE2 QEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGP
700 710 720 730 740 750
1470 1480 1490 1500 1510 1520
pF1KE2 QQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQ
760 770 780 790 800 810
1530 1540 1550 1560 1570 1580
pF1KE2 PYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKM
820 830 840 850 860 870
1590 1600 1610 1620 1630 1640
pF1KE2 QKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVM
880 890 900 910 920 930
1650 1660 1670 1680 1690 1700
pF1KE2 MSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILME
940 950 960 970 980 990
1710 1720 1730 1740 1750 1760
pF1KE2 YEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEK
1000 1010 1020 1030 1040 1050
1770 1780 1790 1800 1810 1820
pF1KE2 SSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQ
1060 1070 1080 1090 1100 1110
1830 1840 1850 1860 1870 1880
pF1KE2 LGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDV
1120 1130 1140 1150 1160 1170
1890 1900 1910 1920 1930 1940
pF1KE2 LSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDS
1180 1190 1200 1210 1220 1230
1950 1960 1970 1980 1990 2000
pF1KE2 LAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEED
1240 1250 1260 1270 1280 1290
2010 2020 2030 2040 2050 2060
pF1KE2 EDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPS
1300 1310 1320 1330 1340 1350
2070 2080 2090 2100 2110 2120
pF1KE2 AEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVG
1360 1370 1380 1390 1400 1410
2130 2140 2150 2160 2170 2180
pF1KE2 DRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLM
1420 1430 1440 1450 1460 1470
2190 2200 2210 2220 2230 2240
pF1KE2 HMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVIC
1480 1490 1500 1510 1520 1530
pF1KE2 DVLFQIGQL
:::::::::
XP_016 DVLFQIGQL
2249 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 11 16:56:31 2016 done: Fri Nov 11 16:56:35 2016
Total Scan time: 26.390 Total Display time: 1.700
Function used was FASTA [36.3.4 Apr, 2011]