FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2662, 247 aa 1>>>pF1KE2662 247 - 247 aa - 247 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7006+/-0.000773; mu= 17.9342+/- 0.046 mean_var=63.9726+/-13.167, 0's: 0 Z-trim(108.1): 19 B-trim: 0 in 0/49 Lambda= 0.160353 statistics sampled from 9966 (9977) to 9966 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.306), width: 16 Scan time: 1.600 The best scores are: opt bits E(32554) CCDS33691.1 LHFPL4 gene_id:375323|Hs108|chr3 ( 247) 1704 402.5 1.4e-112 CCDS4812.1 LHFPL5 gene_id:222662|Hs108|chr6 ( 219) 994 238.2 3.5e-63 CCDS9369.1 LHFP gene_id:10186|Hs108|chr13 ( 200) 331 84.8 4.8e-17 CCDS4042.1 LHFPL2 gene_id:10184|Hs108|chr5 ( 228) 282 73.5 1.4e-13 CCDS14562.1 LHFPL1 gene_id:340596|Hs108|chrX ( 220) 280 73.0 1.8e-13 >>CCDS33691.1 LHFPL4 gene_id:375323|Hs108|chr3 (247 aa) initn: 1704 init1: 1704 opt: 1704 Z-score: 2134.9 bits: 402.5 E(32554): 1.4e-112 Smith-Waterman score: 1704; 100.0% identity (100.0% similar) in 247 aa overlap (1-247:1-247) 10 20 30 40 50 60 pF1KE2 MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPGYFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPGYFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 LFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFSLFFFCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 LFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFSLFFFCN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAYILA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 TATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAYILA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 IIGILNALILSFLAFVLGNRQTDLLQEELKPENKDFVGSTVSSVLRPGGDVSGWGVLPCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 IIGILNALILSFLAFVLGNRQTDLLQEELKPENKDFVGSTVSSVLRPGGDVSGWGVLPCP 190 200 210 220 230 240 pF1KE2 VAHSQGP ::::::: CCDS33 VAHSQGP >>CCDS4812.1 LHFPL5 gene_id:222662|Hs108|chr6 (219 aa) initn: 989 init1: 649 opt: 994 Z-score: 1247.9 bits: 238.2 E(32554): 3.5e-63 Smith-Waterman score: 994; 61.8% identity (84.8% similar) in 217 aa overlap (1-217:4-219) 10 20 30 40 50 pF1KE2 MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPG .::.:::.:.:: .:.:::::.::.:. .::::... ...::::::.::::.::. : CCDS48 MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 YFGLFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFSLFF ::::: ::::. :.. :: :.:. :::.::: :::.: ::: :.: ::.: : :::::: CCDS48 YFGLFSYCVGNVLSS-ELICKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFF 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 FCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAY .::::::::::::::: :: :..::...:::::. .: ::: .::::.:: :..:::. CCDS48 ICNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 ILAIIGILNALILSFLAFVLGNRQTDLLQEELKPENKDFVGSTVSSVLRPGGDVSGWGVL .:::..: .:::::::::::: :: :: .. : .. . : CCDS48 MLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV 180 190 200 210 240 pF1KE2 PCPVAHSQGP >>CCDS9369.1 LHFP gene_id:10186|Hs108|chr13 (200 aa) initn: 290 init1: 190 opt: 331 Z-score: 419.5 bits: 84.8 E(32554): 4.8e-17 Smith-Waterman score: 331; 29.9% identity (60.8% similar) in 194 aa overlap (23-201:9-195) 10 20 30 40 50 60 pF1KE2 MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPGYFG ::.::.... : . : :..:::. : . :: :: CCDS93 MASSLTCTGVIWALLSFLCAATSCVGFFMPYWLWGS-QLGKPVSFG 10 20 30 40 70 80 90 100 pF1KE2 LFHYC-VGSGLAGRELT-----CRGSFTDFSTIPSSAFK--------AAAFFVLLSMVLI :. : .:.. : : ...:. :::. .. . ....:.... . CCDS93 TFRRCSYPVHDESRQMMVMVEEC-GRYASFQGIPSAEWRICTIVTGLGCGLLLLVALTAL 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE2 LGCITCFSLFFFCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKY .:: : : .. . :: .. . .:.:..: . :: ..: :::.: .:. :: .:.. CCDS93 MGC--CVSDLI---SRTVGRVAGGIQFLGGLLIGAGCALYPLGWDSEEVRQTCGYTSGQF 110 120 130 140 150 170 180 190 200 210 220 pF1KE2 SLGDCSVRWAYILAIIGILNALIL-SFLAFVLGNRQTDLLQEELKPENKDFVGSTVSSVL .:: : . ::: . : :..: ..:: :..: CCDS93 DLGKCEIGWAYYCTGAGATAAMLLCTWLACFSGKKQKHYPY 160 170 180 190 200 230 240 pF1KE2 RPGGDVSGWGVLPCPVAHSQGP >>CCDS4042.1 LHFPL2 gene_id:10184|Hs108|chr5 (228 aa) initn: 142 init1: 142 opt: 282 Z-score: 357.5 bits: 73.5 E(32554): 1.4e-13 Smith-Waterman score: 306; 26.8% identity (60.5% similar) in 228 aa overlap (14-217:3-225) 10 20 30 40 50 pF1KE2 MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYW-VGDSVS------- : . . :.. ::....: :. ....:.. : .: . : CCDS40 MCHVIVTCRSM--LWTLLSIVVAFAELIAFMSADWLIGKARSRGGVEPA 10 20 30 40 60 70 80 90 100 pF1KE2 -----TPKPGY--FGLFHYCV---GSGLAGRELTCRGSFTD-FSTIPSSAFKAAAFFVLL .:.: . .:.. :. : :. : : ... :. : :. ..:.:.:. . CCDS40 GPGGGSPEPYHPTLGIYARCIRNPGVQHFQRDTLC-GPYAESFGEIASGFWQATAIFLAV 50 60 70 80 90 100 110 120 130 140 150 pF1KE2 SMVLILGCITCFSLFFFCNTA----TVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRD . ..:: .. :.: .: . .....:. .: .:.: :.:: ...: :: . : CCDS40 G-IFILCMVALVSVFTMCVQSIMKKSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAID 110 120 130 140 150 160 160 170 180 190 200 210 pF1KE2 MCGAKTGKYSLGDCSVRWAYILAIIG-ILNALILSFLAFVLGNRQTDLLQEELKPENKDF .:: .. :. ::::. ::. :: : .:. . : : . ..: .:::.. :.:.. CCDS40 YCGHYASAYKPGDCSLGWAFYTAIGGTVLTFICAVFSAQAEIATSSDKVQEEIE-EGKNL 170 180 190 200 210 220 220 230 240 pF1KE2 VGSTVSSVLRPGGDVSGWGVLPCPVAHSQGP . CCDS40 ICLL >>CCDS14562.1 LHFPL1 gene_id:340596|Hs108|chrX (220 aa) initn: 244 init1: 135 opt: 280 Z-score: 355.2 bits: 73.0 E(32554): 1.8e-13 Smith-Waterman score: 280; 25.7% identity (55.8% similar) in 226 aa overlap (16-227:1-220) 10 20 30 40 50 pF1KE2 MLPSQEASKLYHEHYMRNS-RAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPGYF ::.: .:.:::.... :. . . .. :::. : . :: : CCDS14 MRSSLTMVGTLWAFLSLVTAVTSSTSYFLPYWLFGS-QMGKPVSF 10 20 30 40 60 70 80 90 100 pF1KE2 GLFHYCV----GSGLAGRELTCRGSFTDFSTIPSSAFK--------AAAFFVLLSMVLIL . :. : : : . . : ...:..::: :.. . :...:.... .: CCDS14 STFRRCNYPVRGEGHSLIMVEECGRYASFNAIPSLAWQMCTVVTGAGCALLLLVALAAVL 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE2 GCITCFSLFFFCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYS :: :. .. . . . . :....: . :: ..: ::.. : . :: ..... CCDS14 GC--CMEELI---SRMMGRCMGAAQFVGGLLISSGCALYPLGWNSPEIMQTCGNVSNQFQ 110 120 130 140 150 170 180 190 200 210 220 pF1KE2 LGDCSVRWAYILAIIGILNA-LILSFLAFVLGNRQTDLLQEELKPENKDFVGSTVSSVLR :: : . ::: : : : :: ..:. : .. : .: . . .. :. CCDS14 LGTCRLGWAYYCAGGGAAAAMLICTWLSCFAGRNPKPVILVESIMRNTNSYAMELDHCLK 160 170 180 190 200 210 230 240 pF1KE2 PGGDVSGWGVLPCPVAHSQGP : CCDS14 P 220 247 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Jan 20 09:29:43 2017 done: Fri Jan 20 09:29:43 2017 Total Scan time: 1.600 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]