Result of FASTA (omim) for
pF1KE2692
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2692, 726 aa
1>>>pF1KE2692 726 - 726 aa - 726 aa
Library: /omim/omim.rfq.tfa
62035967 residues in 87258 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9689+/-0.000344; mu= 22.5335+/- 0.022
mean_var=73.3132+/-14.895, 0's: 0 Z-trim(114.3): 65 B-trim: 0 in 0/54
Lambda= 0.149790
statistics sampled from 24346 (24413) to 24346 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.635), E-opt: 0.2 (0.28), width: 16
Scan time: 5.640
The best scores are: opt bits E(87258)
XP_005272739 (OMIM: 300368) PREDICTED: sodium/hydr ( 726) 4774 1041.4 0
XP_016885394 (OMIM: 300368) PREDICTED: sodium/hydr ( 726) 4774 1041.4 0
XP_011542292 (OMIM: 300368) PREDICTED: sodium/hydr ( 726) 4774 1041.4 0
XP_005272738 (OMIM: 300368) PREDICTED: sodium/hydr ( 726) 4774 1041.4 0
NP_001244220 (OMIM: 300368) sodium/hydrogen exchan ( 726) 4774 1041.4 0
NP_115980 (OMIM: 300368) sodium/hydrogen exchanger ( 725) 4743 1034.7 0
XP_006724627 (OMIM: 300368) PREDICTED: sodium/hydr ( 706) 3533 773.2 0
XP_016885395 (OMIM: 300368) PREDICTED: sodium/hydr ( 706) 3533 773.2 0
NP_001036002 (OMIM: 300231,300243) sodium/hydrogen ( 701) 2595 570.5 8.1e-162
NP_001171122 (OMIM: 300231,300243) sodium/hydrogen ( 649) 2556 562.0 2.6e-159
XP_016884712 (OMIM: 300231,300243) PREDICTED: sodi ( 649) 2556 562.0 2.6e-159
XP_016884713 (OMIM: 300231,300243) PREDICTED: sodi ( 649) 2556 562.0 2.6e-159
XP_006724789 (OMIM: 300231,300243) PREDICTED: sodi ( 649) 2556 562.0 2.6e-159
XP_016861691 (OMIM: 608396,613410) PREDICTED: sodi ( 578) 2190 482.9 1.6e-135
NP_775924 (OMIM: 608396,613410) sodium/hydrogen ex ( 645) 2190 483.0 1.7e-135
NP_001317581 (OMIM: 300231,300243) sodium/hydrogen ( 617) 2038 450.1 1.3e-125
XP_016884714 (OMIM: 300231,300243) PREDICTED: sodi ( 617) 2038 450.1 1.3e-125
NP_006350 (OMIM: 300231,300243) sodium/hydrogen ex ( 669) 2038 450.1 1.3e-125
XP_016861692 (OMIM: 608396,613410) PREDICTED: sodi ( 528) 1855 410.5 9e-114
XP_011511005 (OMIM: 608396,613410) PREDICTED: sodi ( 429) 1385 308.8 2.9e-83
XP_011511006 (OMIM: 608396,613410) PREDICTED: sodi ( 369) 1317 294.1 6.9e-79
NP_056081 (OMIM: 612730) sodium/hydrogen exchanger ( 581) 913 207.0 1.8e-52
NP_001247420 (OMIM: 612730) sodium/hydrogen exchan ( 597) 721 165.5 5.8e-40
XP_016879083 (OMIM: 600477) PREDICTED: sodium/hydr ( 544) 689 158.5 6.6e-38
NP_001310900 (OMIM: 600477) sodium/hydrogen exchan ( 675) 689 158.6 7.7e-38
NP_001310902 (OMIM: 600477) sodium/hydrogen exchan ( 895) 689 158.7 9.5e-38
NP_004585 (OMIM: 600477) sodium/hydrogen exchanger ( 896) 689 158.7 9.5e-38
NP_004165 (OMIM: 182307,616868) sodium/hydrogen ex ( 834) 678 156.3 4.7e-37
NP_003039 (OMIM: 600530) sodium/hydrogen exchanger ( 812) 672 155.0 1.1e-36
XP_011540323 (OMIM: 107310,616291) PREDICTED: sodi ( 705) 649 150.0 3.2e-35
NP_003038 (OMIM: 107310,616291) sodium/hydrogen ex ( 815) 649 150.0 3.5e-35
NP_001011552 (OMIM: 600531) sodium/hydrogen exchan ( 798) 642 148.5 1e-34
NP_001271280 (OMIM: 182307,616868) sodium/hydrogen ( 825) 642 148.5 1e-34
XP_011527041 (OMIM: 612730) PREDICTED: sodium/hydr ( 589) 635 146.9 2.3e-34
XP_016883243 (OMIM: 612730) PREDICTED: sodium/hydr ( 565) 547 127.8 1.2e-28
XP_011527042 (OMIM: 612730) PREDICTED: sodium/hydr ( 564) 546 127.6 1.4e-28
XP_011527038 (OMIM: 612730) PREDICTED: sodium/hydr ( 630) 546 127.7 1.5e-28
XP_011527045 (OMIM: 612730) PREDICTED: sodium/hydr ( 334) 541 126.4 1.9e-28
XP_016883245 (OMIM: 612730) PREDICTED: sodium/hydr ( 334) 541 126.4 1.9e-28
XP_016883244 (OMIM: 612730) PREDICTED: sodium/hydr ( 395) 541 126.4 2.2e-28
XP_011527044 (OMIM: 612730) PREDICTED: sodium/hydr ( 395) 541 126.4 2.2e-28
XP_011527039 (OMIM: 612730) PREDICTED: sodium/hydr ( 602) 541 126.6 3e-28
XP_006723819 (OMIM: 612730) PREDICTED: sodium/hydr ( 614) 541 126.6 3.1e-28
NP_001310901 (OMIM: 600477) sodium/hydrogen exchan ( 795) 542 126.9 3.2e-28
XP_011509460 (OMIM: 600531) PREDICTED: sodium/hydr ( 769) 521 122.3 7.2e-27
XP_011527040 (OMIM: 612730) PREDICTED: sodium/hydr ( 591) 469 111.0 1.4e-23
XP_011527046 (OMIM: 612730) PREDICTED: sodium/hydr ( 304) 462 109.3 2.5e-23
NP_001310903 (OMIM: 600477) sodium/hydrogen exchan ( 600) 272 68.4 9.5e-11
NP_001310904 (OMIM: 600477) sodium/hydrogen exchan ( 601) 272 68.4 9.5e-11
XP_011527043 (OMIM: 612730) PREDICTED: sodium/hydr ( 558) 247 63.0 3.8e-09
>>XP_005272739 (OMIM: 300368) PREDICTED: sodium/hydrogen (726 aa)
initn: 4774 init1: 4774 opt: 4774 Z-score: 5571.0 bits: 1041.4 E(87258): 0
Smith-Waterman score: 4774; 100.0% identity (100.0% similar) in 726 aa overlap (1-726:1-726)
10 20 30 40 50 60
pF1KE2 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
670 680 690 700 710 720
pF1KE2 PLEDNA
::::::
XP_005 PLEDNA
>>XP_016885394 (OMIM: 300368) PREDICTED: sodium/hydrogen (726 aa)
initn: 4774 init1: 4774 opt: 4774 Z-score: 5571.0 bits: 1041.4 E(87258): 0
Smith-Waterman score: 4774; 100.0% identity (100.0% similar) in 726 aa overlap (1-726:1-726)
10 20 30 40 50 60
pF1KE2 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
670 680 690 700 710 720
pF1KE2 PLEDNA
::::::
XP_016 PLEDNA
>>XP_011542292 (OMIM: 300368) PREDICTED: sodium/hydrogen (726 aa)
initn: 4774 init1: 4774 opt: 4774 Z-score: 5571.0 bits: 1041.4 E(87258): 0
Smith-Waterman score: 4774; 100.0% identity (100.0% similar) in 726 aa overlap (1-726:1-726)
10 20 30 40 50 60
pF1KE2 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
670 680 690 700 710 720
pF1KE2 PLEDNA
::::::
XP_011 PLEDNA
>>XP_005272738 (OMIM: 300368) PREDICTED: sodium/hydrogen (726 aa)
initn: 4774 init1: 4774 opt: 4774 Z-score: 5571.0 bits: 1041.4 E(87258): 0
Smith-Waterman score: 4774; 100.0% identity (100.0% similar) in 726 aa overlap (1-726:1-726)
10 20 30 40 50 60
pF1KE2 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
670 680 690 700 710 720
pF1KE2 PLEDNA
::::::
XP_005 PLEDNA
>>NP_001244220 (OMIM: 300368) sodium/hydrogen exchanger (726 aa)
initn: 4774 init1: 4774 opt: 4774 Z-score: 5571.0 bits: 1041.4 E(87258): 0
Smith-Waterman score: 4774; 100.0% identity (100.0% similar) in 726 aa overlap (1-726:1-726)
10 20 30 40 50 60
pF1KE2 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
670 680 690 700 710 720
pF1KE2 PLEDNA
::::::
NP_001 PLEDNA
>>NP_115980 (OMIM: 300368) sodium/hydrogen exchanger 7 i (725 aa)
initn: 2566 init1: 2566 opt: 4743 Z-score: 5534.8 bits: 1034.7 E(87258): 0
Smith-Waterman score: 4743; 99.6% identity (99.7% similar) in 726 aa overlap (1-726:1-725)
10 20 30 40 50 60
pF1KE2 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
::::::::::::::::::::::::::::::::::::::::::: .: :::::::::::::
NP_115 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGV-NANVTKFTKLHCFPLL
310 320 330 340 350
370 380 390 400 410 420
pF1KE2 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE2 GVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE2 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE2 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
660 670 680 690 700 710
pF1KE2 PLEDNA
::::::
NP_115 PLEDNA
720
>>XP_006724627 (OMIM: 300368) PREDICTED: sodium/hydrogen (706 aa)
initn: 3617 init1: 3524 opt: 3533 Z-score: 4121.8 bits: 773.2 E(87258): 0
Smith-Waterman score: 4574; 97.2% identity (97.2% similar) in 726 aa overlap (1-726:1-706)
10 20 30 40 50 60
pF1KE2 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
:: ::::::::::::::::::::::::::::::::::::::
XP_006 GV--------------------DPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
550 560 570 580
610 620 630 640 650 660
pF1KE2 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE2 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
650 660 670 680 690 700
pF1KE2 PLEDNA
::::::
XP_006 PLEDNA
>>XP_016885395 (OMIM: 300368) PREDICTED: sodium/hydrogen (706 aa)
initn: 3617 init1: 3524 opt: 3533 Z-score: 4121.8 bits: 773.2 E(87258): 0
Smith-Waterman score: 4574; 97.2% identity (97.2% similar) in 726 aa overlap (1-726:1-706)
10 20 30 40 50 60
pF1KE2 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
:: ::::::::::::::::::::::::::::::::::::::
XP_016 GV--------------------DPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFR
550 560 570 580
610 620 630 640 650 660
pF1KE2 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEG
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE2 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVF
650 660 670 680 690 700
pF1KE2 PLEDNA
::::::
XP_016 PLEDNA
>>NP_001036002 (OMIM: 300231,300243) sodium/hydrogen exc (701 aa)
initn: 3182 init1: 2546 opt: 2595 Z-score: 3026.3 bits: 570.5 E(87258): 8.1e-162
Smith-Waterman score: 3097; 69.4% identity (86.0% similar) in 716 aa overlap (13-725:13-686)
10 20 30 40 50
pF1KE2 MEPGDAARPGSGRATGAPP-PRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAM-EELA
:..:. : : :. :: : .. : :.::..:.. .. :: ::..
NP_001 MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGG--EARAMDEEIV
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 TEKEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRY
.::.:::::::::..:: :::::::::::::::::::.::::::::::::::.::..:::
NP_001 SEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRY
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 GTPATSGRDK-SLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVT
: . : .. .::: .. .::::::::::.:: :::::: ..:.:..:.::::::
NP_001 GIHVPSDVNNVTLSCEVQSSP-TTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 FDPEVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLM
::::::::::::::::.::::::.:::::::::::::::::::.:::.::..::: : ::
NP_001 FDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLM
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 KIMGQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIV
:. :::. ::.::::.::::.::::::::::::.::..::.::::::::::::::::::
NP_001 KVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIV
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 LSSSIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCF
:::::::::::: :.:.::..:.:::.:::::::::::.:::.::::::::::::::. :
NP_001 LSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREF
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE2 PLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVL
::::.::::::::::::::: ::::::::::::::::::::::::.::. :::::::.:
NP_001 QLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELL
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE2 HFLAENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIG
.:::::::::::::.:::::.:::.: :..::::::::::::.:::::..:::::: :::
NP_001 NFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIG
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE2 WNFQHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLN
::::::::.::::::::::::::::.:::::::.:::::::::::..::::: ::: :.
NP_001 SNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLH
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE2 IRVGVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAW
::::: . :: :: .:: :.. : :: ::::
NP_001 IRVGV----DSDQ-EH------LGV--------------------PENER-RTTKAESAW
540 550 560
600 610 620 630 640 650
pF1KE2 IFRLWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFIL
.::.::.::::::::.:::::::::::::: :: .::::::::.:.::: :...:::.::
NP_001 LFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLIL
570 580 590 600 610 620
660 670 680 690 700 710
pF1KE2 TEGDLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTR
..::..::::::::... ..:: : . :. :::..:.:.:..::... ::::
NP_001 NDGDISLTYGDSTVNTEPATSS--APRRFMGN-----SSEDALDRELAFGDHELVIRGTR
630 640 650 660 670
720
pF1KE2 LVFPLEDNA
::.:..:.
NP_001 LVLPMDDSEPPLNLLDNTRHGPA
680 690 700
>>NP_001171122 (OMIM: 300231,300243) sodium/hydrogen exc (649 aa)
initn: 3182 init1: 2546 opt: 2556 Z-score: 2981.2 bits: 562.0 E(87258): 2.6e-159
Smith-Waterman score: 3058; 71.7% identity (87.5% similar) in 672 aa overlap (55-725:3-634)
30 40 50 60 70 80
pF1KE2 LPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATEKEAEESHRQDSVSLLTFILLLTLT
::...::.:::::::::..:: ::::::::
NP_001 MDEEIVSEKQAEESHRQDSANLLIFILLLTLT
10 20 30
90 100 110 120 130 140
pF1KE2 ILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGTPATSGRDK-SLSCTQEDRAFSTLL
:::::::::::.::::::::::::::.::..:::: . : .. .::: .. .:::
NP_001 ILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSP-TTLL
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE2 VNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRH
:::::::.:: :::::: ..:.:..:.::::::::::::::::::::::.::::::.::
NP_001 VNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRH
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE2 FFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIMGQLSDKFYYTDCLFFGAIISATD
:::::::::::::::::.:::.::..::: : :::. :::. ::.::::.::::.::::
NP_001 FFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATD
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE2 PVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAGLNTHAFDAAAFFKS
::::::::.::..::.:::::::::::::::::::::::::::::: :.:.::..:.:::
NP_001 PVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKS
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE2 VGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLLETALFFLMSWSTFLLAEACGFTG
.:::::::::::.:::.::::::::::::::. : ::::.::::::::::::::: ::::
NP_001 IGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTG
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE2 VVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFLAENFIFSYMGLALFTFQKHVFSP
::::::::::::::::::::.::. :::::::.:.:::::::::::::.:::::.:::.:
NP_001 VVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNP
340 350 360 370 380 390
450 460 470 480 490 500
pF1KE2 IFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNFQHMMMFSGLRGAMAFALAIRDTA
:..::::::::::::.:::::..:::::: ::: ::::::::.::::::::::::::::
NP_001 TFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTA
400 410 420 430 440 450
510 520 530 540 550 560
pF1KE2 SYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRVGVEEPSEEDQNEHHWQYFRVGVD
.:::::::.:::::::::::..::::: ::: :.:::::. :: :: .::
NP_001 TYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDS----DQ-EH------LGV-
460 470 480 490
570 580 590 600 610 620
pF1KE2 PDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFRLWYSFDHNYLKPILTHSGPPLTT
:.. : :: ::::.::.::.::::::::.::::::::::
NP_001 -------------------PENER-RTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTT
500 510 520 530
630 640 650 660 670 680
pF1KE2 TLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEGDLTLTYGDSTVTANGSSSSHTAS
:::: :: .::::::::.:.::: :...:::.::..::..::::::::... ..:: :
NP_001 TLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSS--AP
540 550 560 570 580 590
690 700 710 720
pF1KE2 TSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVFPLEDNA
. : .:::..:.:.:..::... ::::::.:..:.
NP_001 RRFMG-----NSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
600 610 620 630 640
726 residues in 1 query sequences
62035967 residues in 87258 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Jun 23 13:29:01 2017 done: Fri Jun 23 13:29:02 2017
Total Scan time: 5.640 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]