Result of FASTA (omim) for
pF1KE2719
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2719, 2590 aa
1>>>pF1KE2719 2590 - 2590 aa - 2590 aa
Library: /omim/omim.rfq.tfa
63842531 residues in 89799 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3661+/-0.000551; mu= 22.0068+/- 0.034
mean_var=109.6930+/-22.777, 0's: 0 Z-trim(108.8): 98 B-trim: 264 in 1/53
Lambda= 0.122457
statistics sampled from 17310 (17403) to 17310 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.525), E-opt: 0.2 (0.194), width: 16
Scan time: 11.760
The best scores are: opt bits E(89799)
NP_955452 (OMIM: 604419) DNA polymerase theta [Hom (2590) 16962 3009.8 0
XP_011510649 (OMIM: 604419) PREDICTED: DNA polymer (2591) 16950 3007.7 0
XP_011510650 (OMIM: 604419) PREDICTED: DNA polymer (2420) 15842 2811.9 0
XP_016861054 (OMIM: 604419) PREDICTED: DNA polymer (2201) 14397 2556.6 0
XP_011510654 (OMIM: 604419) PREDICTED: DNA polymer (2183) 14244 2529.6 0
XP_011510645 (OMIM: 604419) PREDICTED: DNA polymer (2545) 13964 2480.1 0
XP_011510656 (OMIM: 604419) PREDICTED: DNA polymer (1828) 11845 2105.7 0
XP_006714139 (OMIM: 606769) PREDICTED: helicase PO ( 950) 701 136.7 1.6e-30
XP_016863169 (OMIM: 606769) PREDICTED: helicase PO ( 928) 700 136.5 1.8e-30
XP_005262770 (OMIM: 606769) PREDICTED: helicase PO ( 995) 700 136.5 1.9e-30
XP_016863168 (OMIM: 606769) PREDICTED: helicase PO ( 997) 700 136.5 1.9e-30
NP_001284684 (OMIM: 606769) helicase POLQ-like iso (1034) 700 136.5 1.9e-30
XP_005262768 (OMIM: 606769) PREDICTED: helicase PO (1064) 700 136.5 2e-30
NP_598375 (OMIM: 606769) helicase POLQ-like isofor (1101) 700 136.5 2e-30
XP_011529882 (OMIM: 606769) PREDICTED: helicase PO ( 606) 599 118.5 3e-25
XP_016863170 (OMIM: 606769) PREDICTED: helicase PO ( 683) 599 118.6 3.3e-25
NP_001284686 (OMIM: 606769) helicase POLQ-like iso ( 557) 584 115.8 1.7e-24
NP_001284685 (OMIM: 606769) helicase POLQ-like iso ( 604) 584 115.9 1.9e-24
XP_016863172 (OMIM: 606769) PREDICTED: helicase PO ( 604) 584 115.9 1.9e-24
XP_016863171 (OMIM: 606769) PREDICTED: helicase PO ( 604) 584 115.9 1.9e-24
NP_861524 (OMIM: 610887) DNA polymerase nu [Homo s ( 900) 477 97.1 1.2e-18
XP_016859092 (OMIM: 601664,610359) PREDICTED: U5 s (2136) 284 63.3 4.5e-08
NP_054733 (OMIM: 601664,610359) U5 small nuclear r (2136) 284 63.3 4.5e-08
XP_016855985 (OMIM: 615684,615724) PREDICTED: prob ( 816) 277 61.7 5e-08
XP_016855984 (OMIM: 615684,615724) PREDICTED: prob ( 816) 277 61.7 5e-08
XP_016855983 (OMIM: 615684,615724) PREDICTED: prob ( 876) 277 61.7 5.3e-08
XP_011539161 (OMIM: 615684,615724) PREDICTED: prob (1044) 277 61.8 6.1e-08
XP_016855981 (OMIM: 615684,615724) PREDICTED: prob (1114) 277 61.8 6.4e-08
XP_011539159 (OMIM: 615684,615724) PREDICTED: prob (1294) 277 61.9 7.2e-08
XP_016855980 (OMIM: 615684,615724) PREDICTED: prob (1391) 277 61.9 7.6e-08
XP_011539157 (OMIM: 615684,615724) PREDICTED: prob (1393) 277 61.9 7.6e-08
XP_011539154 (OMIM: 615684,615724) PREDICTED: prob (1435) 277 61.9 7.8e-08
XP_011539153 (OMIM: 615684,615724) PREDICTED: prob (1435) 277 61.9 7.8e-08
XP_011539151 (OMIM: 615684,615724) PREDICTED: prob (1435) 277 61.9 7.8e-08
XP_011539152 (OMIM: 615684,615724) PREDICTED: prob (1435) 277 61.9 7.8e-08
NP_001017975 (OMIM: 615684,615724) probable ATP-de (1435) 277 61.9 7.8e-08
XP_016855979 (OMIM: 615684,615724) PREDICTED: prob (1408) 274 61.4 1.1e-07
XP_016855982 (OMIM: 615684,615724) PREDICTED: prob ( 878) 268 60.2 1.6e-07
XP_011513117 (OMIM: 600478,614602) PREDICTED: heli (1033) 254 57.7 1e-06
NP_008860 (OMIM: 600478,614602) helicase SKI2W [Ho (1246) 254 57.8 1.2e-06
XP_011530405 (OMIM: 613974) PREDICTED: probable AT (1682) 249 57.0 2.7e-06
NP_060101 (OMIM: 613974) probable ATP-dependent RN (1712) 249 57.0 2.7e-06
XP_016865695 (OMIM: 614217) PREDICTED: activating (1729) 242 55.8 6.5e-06
XP_016865694 (OMIM: 614217) PREDICTED: activating (2104) 242 55.8 7.6e-06
XP_011533697 (OMIM: 614217) PREDICTED: activating (2104) 242 55.8 7.6e-06
XP_011533698 (OMIM: 614217) PREDICTED: activating (2104) 242 55.8 7.6e-06
NP_006819 (OMIM: 614217) activating signal cointeg (2202) 242 55.9 7.9e-06
XP_011533696 (OMIM: 614217) PREDICTED: activating (2207) 242 55.9 7.9e-06
XP_011530711 (OMIM: 616725) PREDICTED: probable AT (1093) 233 54.0 1.4e-05
XP_016864320 (OMIM: 616725) PREDICTED: probable AT (1093) 233 54.0 1.4e-05
>>NP_955452 (OMIM: 604419) DNA polymerase theta [Homo sa (2590 aa)
initn: 16962 init1: 16962 opt: 16962 Z-score: 16189.3 bits: 3009.8 E(89799): 0
Smith-Waterman score: 16962; 99.9% identity (99.9% similar) in 2590 aa overlap (1-2590:1-2590)
10 20 30 40 50 60
pF1KE2 MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 VPDYEIDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG
::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 VPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 KSREHTSSFNCNFQNGNQEHQRCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::
NP_955 KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE2 HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE2 QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KE2 KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDRTGLSRKR
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::
NP_955 KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKR
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KE2 KLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 KLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGA
2530 2540 2550 2560 2570 2580
2590
pF1KE2 SWGELKDFDV
::::::::::
NP_955 SWGELKDFDV
2590
>>XP_011510649 (OMIM: 604419) PREDICTED: DNA polymerase (2591 aa)
initn: 16948 init1: 16473 opt: 16950 Z-score: 16177.8 bits: 3007.7 E(89799): 0
Smith-Waterman score: 16950; 99.8% identity (99.9% similar) in 2591 aa overlap (1-2590:1-2591)
10 20 30 40 50 60
pF1KE2 MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 VPDYEIDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG
::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 KSREHTSSFNCNFQNGNQEHQRCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::
XP_011 KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE2 HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE2 QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510
pF1KE2 KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDRT-GLSRK
::::::::::::::::::::::::::::::::::::::::::::::::::::.: :::::
XP_011 KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTVGLSRK
2470 2480 2490 2500 2510 2520
2520 2530 2540 2550 2560 2570
pF1KE2 RKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIG
2530 2540 2550 2560 2570 2580
2580 2590
pF1KE2 ASWGELKDFDV
:::::::::::
XP_011 ASWGELKDFDV
2590
>>XP_011510650 (OMIM: 604419) PREDICTED: DNA polymerase (2420 aa)
initn: 15840 init1: 15365 opt: 15842 Z-score: 15120.3 bits: 2811.9 E(89799): 0
Smith-Waterman score: 15842; 99.9% identity (99.9% similar) in 2420 aa overlap (172-2590:1-2420)
150 160 170 180 190 200
pF1KE2 FILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRL
::::::::::::::::::::::::::::::
XP_011 MGSTSPSRHFSSLDIAVCTIERANGLINRL
10 20 30
210 220 230 240 250 260
pF1KE2 IEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQI
40 50 60 70 80 90
270 280 290 300 310 320
pF1KE2 VGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKG
100 110 120 130 140 150
330 340 350 360 370 380
pF1KE2 DEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVI
160 170 180 190 200 210
390 400 410 420 430 440
pF1KE2 LEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLA
220 230 240 250 260 270
450 460 470 480 490 500
pF1KE2 ATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEK
280 290 300 310 320 330
510 520 530 540 550 560
pF1KE2 SKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAA
340 350 360 370 380 390
570 580 590 600 610 620
pF1KE2 SMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSS
400 410 420 430 440 450
630 640 650 660 670 680
pF1KE2 SLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMK
460 470 480 490 500 510
690 700 710 720 730 740
pF1KE2 RVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKY
520 530 540 550 560 570
750 760 770 780 790 800
pF1KE2 GCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSL
580 590 600 610 620 630
810 820 830 840 850 860
pF1KE2 LNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRT
640 650 660 670 680 690
870 880 890 900 910 920
pF1KE2 IWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALLHSSTCSLTHSESEVKEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALLHSSTCSLTHSESEVKEH
700 710 720 730 740 750
930 940 950 960 970 980
pF1KE2 TFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKSREHTSSFNCNFQNGNQEHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKSREHTSSFNCNFQNGNQEHQ
760 770 780 790 800 810
990 1000 1010 1020 1030 1040
pF1KE2 RCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFSQKTKKAPLNFNSEKMSRSFRS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFSQKTKKAPLNFNSEKMSRSFRS
820 830 840 850 860 870
1050 1060 1070 1080 1090 1100
pF1KE2 WKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCEDPFTLDEKKTEFRNSGPFAKNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCEDPFTLDEKKTEFRNSGPFAKNV
880 890 900 910 920 930
1110 1120 1130 1140 1150 1160
pF1KE2 SLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTGSQSKNVTCQATSVVSEKGRGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTGSQSKNVTCQATSVVSEKGRGV
940 950 960 970 980 990
1170 1180 1190 1200 1210 1220
pF1KE2 AVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQSHEQTSTITKQKNIIERQMPCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQSHEQTSTITKQKNIIERQMPCE
1000 1010 1020 1030 1040 1050
1230 1240 1250 1260 1270 1280
pF1KE2 AVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDISRTVIPSEVLPSAGAFSKSEGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDISRTVIPSEVLPSAGAFSKSEGQ
1060 1070 1080 1090 1100 1110
1290 1300 1310 1320 1330 1340
pF1KE2 HENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFEDSFYLDTQSEKIIQQMATENAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFEDSFYLDTQSEKIIQQMATENAK
1120 1130 1140 1150 1160 1170
1350 1360 1370 1380 1390 1400
pF1KE2 LGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQHPLGATKIDHLDLKTVGTMKQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQHPLGATKIDHLDLKTVGTMKQS
1180 1190 1200 1210 1220 1230
1410 1420 1430 1440 1450 1460
pF1KE2 SDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDSQLNSFLQGYQTQETVKPVILL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDSQLNSFLQGYQTQETVKPVILL
1240 1250 1260 1270 1280 1290
1470 1480 1490 1500 1510 1520
pF1KE2 IPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLVKEQLPDMQMKEPLPSEVTSNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLVKEQLPDMQMKEPLPSEVTSNH
1300 1310 1320 1330 1340 1350
1530 1540 1550 1560 1570 1580
pF1KE2 FSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSEMDSVQMVEALDNVDIFPVQEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSEMDSVQMVEALDNVDIFPVQEK
1360 1370 1380 1390 1400 1410
1590 1600 1610 1620 1630 1640
pF1KE2 NHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKLTGTRQNHSFIWSGASFDLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKLTGTRQNHSFIWSGASFDLSPG
1420 1430 1440 1450 1460 1470
1650 1660 1670 1680 1690 1700
pF1KE2 LQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQEVISNLETKQVQGISFSSNNEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQEVISNLETKQVQGISFSSNNEV
1480 1490 1500 1510 1520 1530
1710 1720 1730 1740 1750 1760
pF1KE2 KSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPIPTSASKLTFPGILETPVNPWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPIPTSASKLTFPGILETPVNPWK
1540 1550 1560 1570 1580 1590
1770 1780 1790 1800 1810 1820
pF1KE2 TNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPISDTSFSLQLSQDGLQLTPASSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPISDTSFSLQLSQDGLQLTPASSS
1600 1610 1620 1630 1640 1650
1830 1840 1850 1860 1870 1880
pF1KE2 SESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTATIGSRFKQASSPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTATIGSRFKQASSPQ
1660 1670 1680 1690 1700 1710
1890 1900 1910 1920 1930 1940
pF1KE2 EIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKEQKHSEISASLVPPSLDPSLTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKEQKHSEISASLVPPSLDPSLTL
1720 1730 1740 1750 1760 1770
1950 1960 1970 1980 1990 2000
pF1KE2 KDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQ
1780 1790 1800 1810 1820 1830
2010 2020 2030 2040 2050 2060
pF1KE2 EPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQLN
1840 1850 1860 1870 1880 1890
2070 2080 2090 2100 2110 2120
pF1KE2 SLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQAYQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQAYQLA
1900 1910 1920 1930 1940 1950
2130 2140 2150 2160 2170 2180
pF1KE2 GHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRGIDNGRKLRLGRQFSTSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRGIDNGRKLRLGRQFSTSK
1960 1970 1980 1990 2000 2010
2190 2200 2210 2220 2230 2240
pF1KE2 DVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGR
2020 2030 2040 2050 2060 2070
2250 2260 2270 2280 2290 2300
pF1KE2 ITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQAQMEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQAQMEE
2080 2090 2100 2110 2120 2130
2310 2320 2330 2340 2350 2360
pF1KE2 RAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILAHLSHDRRLIQVLNTGADVFRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILAHLSHDRRLIQVLNTGADVFRS
2140 2150 2160 2170 2180 2190
2370 2380 2390 2400 2410 2420
pF1KE2 IAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYT
2200 2210 2220 2230 2240 2250
2430 2440 2450 2460 2470 2480
pF1KE2 GINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIV
2260 2270 2280 2290 2300 2310
2490 2500 2510 2520 2530 2540
pF1KE2 KIATVNIQKQLETFHSTFKSHGHREGMLQSDRT-GLSRKRKLQGMFCPIRGGFFILQLHD
:::::::::::::::::::::::::::::::.: ::::::::::::::::::::::::::
XP_011 KIATVNIQKQLETFHSTFKSHGHREGMLQSDQTVGLSRKRKLQGMFCPIRGGFFILQLHD
2320 2330 2340 2350 2360 2370
2550 2560 2570 2580 2590
pF1KE2 ELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV
2380 2390 2400 2410 2420
>>XP_016861054 (OMIM: 604419) PREDICTED: DNA polymerase (2201 aa)
initn: 14395 init1: 13920 opt: 14397 Z-score: 13741.2 bits: 2556.6 E(89799): 0
Smith-Waterman score: 14397; 99.9% identity (99.9% similar) in 2201 aa overlap (391-2590:1-2201)
370 380 390 400 410 420
pF1KE2 FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
::::::::::::::::::::::::::::::
XP_016 MDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
10 20 30
430 440 450 460 470 480
pF1KE2 TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
40 50 60 70 80 90
490 500 510 520 530 540
pF1KE2 AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
100 110 120 130 140 150
550 560 570 580 590 600
pF1KE2 GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
160 170 180 190 200 210
610 620 630 640 650 660
pF1KE2 SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
220 230 240 250 260 270
670 680 690 700 710 720
pF1KE2 WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
280 290 300 310 320 330
730 740 750 760 770 780
pF1KE2 TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
340 350 360 370 380 390
790 800 810 820 830 840
pF1KE2 FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
400 410 420 430 440 450
850 860 870 880 890 900
pF1KE2 SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
460 470 480 490 500 510
910 920 930 940 950 960
pF1KE2 CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
520 530 540 550 560 570
970 980 990 1000 1010 1020
pF1KE2 KSREHTSSFNCNFQNGNQEHQRCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::
XP_016 KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
580 590 600 610 620 630
1030 1040 1050 1060 1070 1080
pF1KE2 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
640 650 660 670 680 690
1090 1100 1110 1120 1130 1140
pF1KE2 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
700 710 720 730 740 750
1150 1160 1170 1180 1190 1200
pF1KE2 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
760 770 780 790 800 810
1210 1220 1230 1240 1250 1260
pF1KE2 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
820 830 840 850 860 870
1270 1280 1290 1300 1310 1320
pF1KE2 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
880 890 900 910 920 930
1330 1340 1350 1360 1370 1380
pF1KE2 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
940 950 960 970 980 990
1390 1400 1410 1420 1430 1440
pF1KE2 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
1000 1010 1020 1030 1040 1050
1450 1460 1470 1480 1490 1500
pF1KE2 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
1060 1070 1080 1090 1100 1110
1510 1520 1530 1540 1550 1560
pF1KE2 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
1120 1130 1140 1150 1160 1170
1570 1580 1590 1600 1610 1620
pF1KE2 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
1180 1190 1200 1210 1220 1230
1630 1640 1650 1660 1670 1680
pF1KE2 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
1240 1250 1260 1270 1280 1290
1690 1700 1710 1720 1730 1740
pF1KE2 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
1300 1310 1320 1330 1340 1350
1750 1760 1770 1780 1790 1800
pF1KE2 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
1360 1370 1380 1390 1400 1410
1810 1820 1830 1840 1850 1860
pF1KE2 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
1420 1430 1440 1450 1460 1470
1870 1880 1890 1900 1910 1920
pF1KE2 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
1480 1490 1500 1510 1520 1530
1930 1940 1950 1960 1970 1980
pF1KE2 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
1540 1550 1560 1570 1580 1590
1990 2000 2010 2020 2030 2040
pF1KE2 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
1600 1610 1620 1630 1640 1650
2050 2060 2070 2080 2090 2100
pF1KE2 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
1660 1670 1680 1690 1700 1710
2110 2120 2130 2140 2150 2160
pF1KE2 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS
1720 1730 1740 1750 1760 1770
2170 2180 2190 2200 2210 2220
pF1KE2 TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL
1780 1790 1800 1810 1820 1830
2230 2240 2250 2260 2270 2280
pF1KE2 NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM
1840 1850 1860 1870 1880 1890
2290 2300 2310 2320 2330 2340
pF1KE2 GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA
1900 1910 1920 1930 1940 1950
2350 2360 2370 2380 2390 2400
pF1KE2 HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE
1960 1970 1980 1990 2000 2010
2410 2420 2430 2440 2450 2460
pF1KE2 QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR
2020 2030 2040 2050 2060 2070
2470 2480 2490 2500 2510
pF1KE2 KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDRT-GLSRK
::::::::::::::::::::::::::::::::::::::::::::::::::::.: :::::
XP_016 KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTVGLSRK
2080 2090 2100 2110 2120 2130
2520 2530 2540 2550 2560 2570
pF1KE2 RKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIG
2140 2150 2160 2170 2180 2190
2580 2590
pF1KE2 ASWGELKDFDV
:::::::::::
XP_016 ASWGELKDFDV
2200
>>XP_011510654 (OMIM: 604419) PREDICTED: DNA polymerase (2183 aa)
initn: 14244 init1: 14244 opt: 14244 Z-score: 13595.2 bits: 2529.6 E(89799): 0
Smith-Waterman score: 14244; 99.8% identity (99.9% similar) in 2181 aa overlap (1-2181:1-2181)
10 20 30 40 50 60
pF1KE2 MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 VPDYEIDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG
::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 KSREHTSSFNCNFQNGNQEHQRCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::
XP_011 KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL
::::::::::::::::::: .
XP_011 TRRGIDNGRKLRLGRQFSTRRFK
2170 2180
>>XP_011510645 (OMIM: 604419) PREDICTED: DNA polymerase (2545 aa)
initn: 16644 init1: 13963 opt: 13964 Z-score: 13326.9 bits: 2480.1 E(89799): 0
Smith-Waterman score: 16552; 98.1% identity (98.1% similar) in 2591 aa overlap (1-2590:1-2545)
10 20 30 40 50 60
pF1KE2 MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 VPDYEIDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG
::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 KSREHTSSFNCNFQNGNQEHQRCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::
XP_011 KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS
:::::::::::::::::::::::::::::::::::
XP_011 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAE-------------------------
2110 2120 2130
2170 2180 2190 2200 2210 2220
pF1KE2 TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL
:::::::::::::::::::::::::::::::::::::::
XP_011 ---------------------DVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL
2140 2150 2160 2170
2230 2240 2250 2260 2270 2280
pF1KE2 NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM
2180 2190 2200 2210 2220 2230
2290 2300 2310 2320 2330 2340
pF1KE2 GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA
2240 2250 2260 2270 2280 2290
2350 2360 2370 2380 2390 2400
pF1KE2 HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE
2300 2310 2320 2330 2340 2350
2410 2420 2430 2440 2450 2460
pF1KE2 QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR
2360 2370 2380 2390 2400 2410
2470 2480 2490 2500 2510
pF1KE2 KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDRT-GLSRK
::::::::::::::::::::::::::::::::::::::::::::::::::::.: :::::
XP_011 KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTVGLSRK
2420 2430 2440 2450 2460 2470
2520 2530 2540 2550 2560 2570
pF1KE2 RKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIG
2480 2490 2500 2510 2520 2530
2580 2590
pF1KE2 ASWGELKDFDV
:::::::::::
XP_011 ASWGELKDFDV
2540
>>XP_011510656 (OMIM: 604419) PREDICTED: DNA polymerase (1828 aa)
initn: 11836 init1: 11361 opt: 11845 Z-score: 11305.7 bits: 2105.7 E(89799): 0
Smith-Waterman score: 11845; 99.3% identity (99.6% similar) in 1824 aa overlap (768-2590:7-1828)
740 750 760 770 780 790
pF1KE2 NQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLV
:.. : .::. .::::::::::::::::
XP_011 MDAIVGRFNLCNSQLLF--MQKRLTFGIQRELCDLV
10 20 30
800 810 820 830 840 850
pF1KE2 RVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERR
40 50 60 70 80 90
860 870 880 890 900 910
pF1KE2 NMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALLHSSTCSLTHSESE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALLHSSTCSLTHSESE
100 110 120 130 140 150
920 930 940 950 960 970
pF1KE2 VKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKSREHTSSFNCNFQNGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKSREHTSSFNCNFQNGN
160 170 180 190 200 210
980 990 1000 1010 1020 1030
pF1KE2 QEHQRCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFSQKTKKAPLNFNSEKMSR
:::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFSQKTKKAPLNFNSEKMSR
220 230 240 250 260 270
1040 1050 1060 1070 1080 1090
pF1KE2 SFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCEDPFTLDEKKTEFRNSGPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCEDPFTLDEKKTEFRNSGPF
280 290 300 310 320 330
1100 1110 1120 1130 1140 1150
pF1KE2 AKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTGSQSKNVTCQATSVVSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTGSQSKNVTCQATSVVSEK
340 350 360 370 380 390
1160 1170 1180 1190 1200 1210
pF1KE2 GRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQSHEQTSTITKQKNIIERQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQSHEQTSTITKQKNIIERQ
400 410 420 430 440 450
1220 1230 1240 1250 1260 1270
pF1KE2 MPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDISRTVIPSEVLPSAGAFSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDISRTVIPSEVLPSAGAFSK
460 470 480 490 500 510
1280 1290 1300 1310 1320 1330
pF1KE2 SEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFEDSFYLDTQSEKIIQQMAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFEDSFYLDTQSEKIIQQMAT
520 530 540 550 560 570
1340 1350 1360 1370 1380 1390
pF1KE2 ENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQHPLGATKIDHLDLKTVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQHPLGATKIDHLDLKTVGT
580 590 600 610 620 630
1400 1410 1420 1430 1440 1450
pF1KE2 MKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDSQLNSFLQGYQTQETVKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDSQLNSFLQGYQTQETVKP
640 650 660 670 680 690
1460 1470 1480 1490 1500 1510
pF1KE2 VILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLVKEQLPDMQMKEPLPSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLVKEQLPDMQMKEPLPSEV
700 710 720 730 740 750
1520 1530 1540 1550 1560 1570
pF1KE2 TSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSEMDSVQMVEALDNVDIFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSEMDSVQMVEALDNVDIFP
760 770 780 790 800 810
1580 1590 1600 1610 1620 1630
pF1KE2 VQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKLTGTRQNHSFIWSGASFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKLTGTRQNHSFIWSGASFD
820 830 840 850 860 870
1640 1650 1660 1670 1680 1690
pF1KE2 LSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQEVISNLETKQVQGISFSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQEVISNLETKQVQGISFSS
880 890 900 910 920 930
1700 1710 1720 1730 1740 1750
pF1KE2 NNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPIPTSASKLTFPGILETPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPIPTSASKLTFPGILETPV
940 950 960 970 980 990
1760 1770 1780 1790 1800 1810
pF1KE2 NPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPISDTSFSLQLSQDGLQLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPISDTSFSLQLSQDGLQLTP
1000 1010 1020 1030 1040 1050
1820 1830 1840 1850 1860 1870
pF1KE2 ASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTATIGSRFKQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTATIGSRFKQA
1060 1070 1080 1090 1100 1110
1880 1890 1900 1910 1920 1930
pF1KE2 SSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKEQKHSEISASLVPPSLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKEQKHSEISASLVPPSLDP
1120 1130 1140 1150 1160 1170
1940 1950 1960 1970 1980 1990
pF1KE2 SLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLD
1180 1190 1200 1210 1220 1230
2000 2010 2020 2030 2040 2050
pF1KE2 PDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSM
1240 1250 1260 1270 1280 1290
2060 2070 2080 2090 2100 2110
pF1KE2 NQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQA
1300 1310 1320 1330 1340 1350
2120 2130 2140 2150 2160 2170
pF1KE2 YQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRGIDNGRKLRLGRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRGIDNGRKLRLGRQF
1360 1370 1380 1390 1400 1410
2180 2190 2200 2210 2220 2230
pF1KE2 STSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHT
1420 1430 1440 1450 1460 1470
2240 2250 2260 2270 2280 2290
pF1KE2 ATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQA
1480 1490 1500 1510 1520 1530
2300 2310 2320 2330 2340 2350
pF1KE2 QMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILAHLSHDRRLIQVLNTGAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILAHLSHDRRLIQVLNTGAD
1540 1550 1560 1570 1580 1590
2360 2370 2380 2390 2400 2410
pF1KE2 VFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFK
1600 1610 1620 1630 1640 1650
2420 2430 2440 2450 2460 2470
pF1KE2 SRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSA
1660 1670 1680 1690 1700 1710
2480 2490 2500 2510 2520 2530
pF1KE2 ADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDRT-GLSRKRKLQGMFCPIRGGFFIL
:::::::::::::::::::::::::::::::::::.: ::::::::::::::::::::::
XP_011 ADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTVGLSRKRKLQGMFCPIRGGFFIL
1720 1730 1740 1750 1760 1770
2540 2550 2560 2570 2580 2590
pF1KE2 QLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV
1780 1790 1800 1810 1820
>>XP_006714139 (OMIM: 606769) PREDICTED: helicase POLQ-l (950 aa)
initn: 1128 init1: 369 opt: 701 Z-score: 669.4 bits: 136.7 E(89799): 1.6e-30
Smith-Waterman score: 1267; 34.9% identity (65.5% similar) in 739 aa overlap (4-722:253-941)
10 20 30
pF1KE2 MNLLRRSGKRRRSESGSDSFSG--SGGDSSASP
.: :. : .: .: ... .:. .. .:
XP_006 WKSSSHNTVNEELPHNCIEQPQQNDESSSKVRTSSDMNRRKSIKDHLKNAMTGNAKAQTP
230 240 250 260 270 280
40 50 60 70 80 90
pF1KE2 QFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYEIDKLLLANWGLPKAVLEKYHSF-GVK
: : : : . . : :: . : : ..::. : . : .: :..
XP_006 IF------SRSKQLKDTLLSEEINVAKKTVESSSND--LGPFYSLPSKVRDLYAQFKGIE
290 300 310 320 330
100 110 120 130 140 150
pF1KE2 KMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVA
:..::: :: :..: : :::.:: :::.:::::::.:.:...: :: .:.:::.:...
XP_006 KLYEWQHTCLTLNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYVAIV
340 350 360 370 380 390
160 170 180 190 200
pF1KE2 KEKKYYLQSLFQEVGIKVDGYMGSTS---PSRHFSSLDIAVCTIERANGLINRLIEENKM
.:: :.:. :.:. :. : :: . :... . .. . :::....:.: ::: ...
XP_006 QEKISGLSSFGIELGFFVEEYAGSKGRFPPTKRREKKSLYIATIEKGHSLVNSLIETGRI
400 410 420 430 440 450
210 220 230 240 250 260
pF1KE2 DLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSAT
: ::.::::::::.:.. :: ::. :.:: : .. . ::.:::::
XP_006 DSLGLVVVDELHMIGEGSRGATLEMTLAKILYTSKTT---------------QIIGMSAT
460 470 480 490
270 280 290 300 310 320
pF1KE2 LPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIY--DSSMKLVREFEPMLQVKG----
: :.: . ..:.:: : ..:::: : : .:....:: ::. . : .:. :
XP_006 LNNVEDLQKFLQAEYYTSQFRPVELKEYLKINDTIYEVDSKAENGMTFSRLLNYKYSDTL
500 510 520 530 540 550
330 340 350 360 370
pF1KE2 ---DEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECP
: ::.:.: :.: :.: :.:::::: ::..:..: . : . .. .: .:
XP_006 KKMDPDHLVALVTEVI-PNYSCLVFCPSKKNCENVAEMICK-FLSKEY-----LKHKE--
560 570 580 590 600 610
380 390 400 410 420 430
pF1KE2 PVILEQKELLEVMDQLRRLPSG-LDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLI
:: ::. .:. . .: : ::..:.:.:::.::.::: .:: ..: :. :..
XP_006 ------KEKCEVIKNLKNIGNGNLCPVLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVL
620 630 640 650 660
440 450 460 470 480 490
pF1KE2 RVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICK
... ::::..::::::::::.:.: . . : ::::.::::: :.::.:::::: .
XP_006 CLFTCTSTLAAGVNLPARRVILRAPYVAKEFLKRNQYKQMIGRAGRAGIDTIGESILILQ
670 680 690 700 710 720
500 510 520 530 540 550
pF1KE2 NSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVG-GVASTSQDMHTYAAC
...:.. . :. ::...: .. : . : :.... ..: .:.. .:.. .
XP_006 EKDKQQVLELIT---KPLENCYSHLVQEFTKG--IQTLFLSLIGLKIATNLDDIYHFMNG
730 740 750 760 770
560 570 580 590 600 610
pF1KE2 TFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVY--HPTHL
::... .: . ...:. ..:. . .: :. ..:. . : : : :.:
XP_006 TFFGV-----QQKVLLKEKSLWEITVES-LRYLTEKGLLQKDTIYKSEEEVQYNFHITKL
780 790 800 810 820 830
620 630 640 650 660 670
pF1KE2 GSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPM-FEDWTTIDWYRFFCLW
: :....... : .. ::.....:.:::. ::..::.::. . . . ::. .: .
XP_006 GRASFKGTIDLAYCDILYRDLKKGLEGLVLESLLHLIYLTTPYDLVSQCNPDWMIYFRQF
840 850 860 870 880 890
680 690 700 710 720 730
pF1KE2 EKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVP
.: . . :: ..:: :.:... ..:..... : . .. .:..:
XP_006 SQLSPAEQNVAAILGVSESFIGKKASGQAIGK-EIHSKKKPTLTQFIVSTEDALKLGN
900 910 920 930 940 950
740 750 760 770 780 790
pF1KE2 LREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQREL
>>XP_016863169 (OMIM: 606769) PREDICTED: helicase POLQ-l (928 aa)
initn: 1132 init1: 369 opt: 700 Z-score: 668.6 bits: 136.5 E(89799): 1.8e-30
Smith-Waterman score: 1166; 31.0% identity (60.0% similar) in 872 aa overlap (4-856:147-899)
10 20 30
pF1KE2 MNLLRRSGKRRRSESGSDSFSG--SGGDSSASP
.: :. : .: .: ... .:. .. .:
XP_016 WKSSSHNTVNEELPHNCIEQPQQNDESSSKVRTSSDMNRRKSIKDHLKNAMTGNAKAQTP
120 130 140 150 160 170
40 50 60 70 80 90
pF1KE2 QFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYEIDKLLLANWGLPKAVLEKYHSF-GVK
: : : : . . : :: . : : ..::. : . : .: :..
XP_016 IF------SRSKQLKDTLLSEEINVAKKTVESSSND--LGPFYSLPSKVRDLYAQFKGIE
180 190 200 210 220
100 110 120 130 140 150
pF1KE2 KMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVA
:..::: :: :..: : :::.:: :::.:::::::.:.:...: :: .:.:::.:...
XP_016 KLYEWQHTCLTLNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYVAIV
230 240 250 260 270 280
160 170 180 190 200 210
pF1KE2 KEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLL
.::
XP_016 QEK---------------------------------------------------------
290
220 230 240 250 260 270
pF1KE2 GMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPN
:::.:.. :: ::. :.:: : .. . ::.:::::: :
XP_016 -------LHMIGEGSRGATLEMTLAKILYTSKTT---------------QIIGMSATLNN
300 310 320
280 290 300 310 320
pF1KE2 LELVASWLNAELYHTDFRPVPLLESVKVGNSIY--DSSMKLVREFEPMLQVKG-------
.: . ..:.:: : ..:::: : : .:....:: ::. . : .:. :
XP_016 VEDLQKFLQAEYYTSQFRPVELKEYLKINDTIYEVDSKAENGMTFSRLLNYKYSDTLKKM
330 340 350 360 370 380
330 340 350 360 370 380
pF1KE2 DEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVI
: ::.:.: :.: :.: :.:::::: ::..:..: . : . .. .: .:
XP_016 DPDHLVALVTEVI-PNYSCLVFCPSKKNCENVAEMICK-FLSKEY-----LKHKE-----
390 400 410 420 430
390 400 410 420 430 440
pF1KE2 LEQKELLEVMDQLRRLPSG-LDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVL
:: ::. .:. . .: : ::..:.:.:::.::.::: .:: ..: :. :.. ..
XP_016 ---KEKCEVIKNLKNIGNGNLCPVLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLF
440 450 460 470 480 490
450 460 470 480 490 500
pF1KE2 AATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSE
. ::::..::::::::::.:.: . . : ::::.::::: :.::.:::::: ....
XP_016 TCTSTLAAGVNLPARRVILRAPYVAKEFLKRNQYKQMIGRAGRAGIDTIGESILILQEKD
500 510 520 530 540 550
510 520 530 540 550
pF1KE2 KSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVG-GVASTSQDMHTYAACTFL
:.. . :. ::...: .. : . : :.... ..: .:.. .:.. . ::.
XP_016 KQQVLELI---TKPLENCYSHLVQEFTKG--IQTLFLSLIGLKIATNLDDIYHFMNGTFF
560 570 580 590 600
560 570 580 590 600 610
pF1KE2 AASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVY--HPTHLGSA
.. .: . ...:. ..:. . .: :. ..:. . : : : :.:: :
XP_016 GV-----QQKVLLKEKSLWEITVES-LRYLTEKGLLQKDTIYKSEEEVQYNFHITKLGRA
610 620 630 640 650 660
620 630 640 650 660 670
pF1KE2 TLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPM-FEDWTTIDWYRFFCLWEKL
....... : .. ::.....:.:::. ::..::.::. . . . ::. .: . .:
XP_016 SFKGTIDLAYCDILYRDLKKGLEGLVLESLLHLIYLTTPYDLVSQCNPDWMIYFRQFSQL
670 680 690 700 710 720
680 690 700 710 720 730
pF1KE2 PTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLRE
. . :: ..:: :.:... ..:..... .. . .:.. :.:: :..:. .
XP_016 SPAEQNVAAILGVSESFIGKKASGQAIGKKVDKN----VVNRLYLSFVLYTLLKETNIWT
730 740 750 760 770
740 750 760 770 780 790
pF1KE2 INQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLG--WHNMELLLSQFQKRLTFGIQRELC
...:.. :: ::.: ..: ... . : ..: : .. :: .. :.::. .. ::
XP_016 VSEKFNMPRGYIQNLLTGTASFSSCVLHFCEELEEFW-VYRALLVELTKKLTYCVKAELI
780 790 800 810 820 830
800 810 820 830 840 850
pF1KE2 DLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVE
:..:. . ::. ::..:.... :: :: :: : . . ..:.. :. . ..
XP_016 PLMEVTGVLEGRAKQLYSAGYKSLMHLANANP-EVLVRTIDHLSRRQAKQIVSSAKMLLH
840 850 860 870 880 890
860 870 880 890 900 910
pF1KE2 ERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALLHSSTCSLTHS
:.
XP_016 EKAEALQEEVEELLRLPSDFPGAVASSTDKA
900 910 920
>>XP_005262770 (OMIM: 606769) PREDICTED: helicase POLQ-l (995 aa)
initn: 1293 init1: 369 opt: 700 Z-score: 668.2 bits: 136.5 E(89799): 1.9e-30
Smith-Waterman score: 1434; 33.7% identity (65.1% similar) in 875 aa overlap (4-856:147-966)
10 20 30
pF1KE2 MNLLRRSGKRRRSESGSDSFSG--SGGDSSASP
.: :. : .: .: ... .:. .. .:
XP_005 WKSSSHNTVNEELPHNCIEQPQQNDESSSKVRTSSDMNRRKSIKDHLKNAMTGNAKAQTP
120 130 140 150 160 170
40 50 60 70 80 90
pF1KE2 QFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYEIDKLLLANWGLPKAVLEKYHSF-GVK
: : : : . . : :: . : : ..::. : . : .: :..
XP_005 IF------SRSKQLKDTLLSEEINVAKKTVESSSND--LGPFYSLPSKVRDLYAQFKGIE
180 190 200 210 220
100 110 120 130 140 150
pF1KE2 KMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVA
:..::: :: :..: : :::.:: :::.:::::::.:.:...: :: .:.:::.:...
XP_005 KLYEWQHTCLTLNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYVAIV
230 240 250 260 270 280
160 170 180 190 200
pF1KE2 KEKKYYLQSLFQEVGIKVDGYMGSTS---PSRHFSSLDIAVCTIERANGLINRLIEENKM
.:: :.:. :.:. :. : :: . :... . .. . :::....:.: ::: ...
XP_005 QEKISGLSSFGIELGFFVEEYAGSKGRFPPTKRREKKSLYIATIEKGHSLVNSLIETGRI
290 300 310 320 330 340
210 220 230 240 250 260
pF1KE2 DLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSAT
: ::.::::::::.:.. :: ::. :.:: : .. . ::.:::::
XP_005 DSLGLVVVDELHMIGEGSRGATLEMTLAKILYTSKTT---------------QIIGMSAT
350 360 370 380 390
270 280 290 300 310 320
pF1KE2 LPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIY--DSSMKLVREFEPMLQVKG----
: :.: . ..:.:: : ..:::: : : .:....:: ::. . : .:. :
XP_005 LNNVEDLQKFLQAEYYTSQFRPVELKEYLKINDTIYEVDSKAENGMTFSRLLNYKYSDTL
400 410 420 430 440 450
330 340 350 360 370
pF1KE2 ---DEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECP
: ::.:.: :.: :.: :.:::::: ::..:..: . : . .. .: .:
XP_005 KKMDPDHLVALVTEVI-PNYSCLVFCPSKKNCENVAEMICK-FLSKEY-----LKHKE--
460 470 480 490 500
380 390 400 410 420 430
pF1KE2 PVILEQKELLEVMDQLRRLPSG-LDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLI
:: ::. .:. . .: : ::..:.:.:::.::.::: .:: ..: :. :..
XP_005 ------KEKCEVIKNLKNIGNGNLCPVLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVL
510 520 530 540 550
440 450 460 470 480 490
pF1KE2 RVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICK
... ::::..::::::::::.:.: . . : ::::.::::: :.::.:::::: .
XP_005 CLFTCTSTLAAGVNLPARRVILRAPYVAKEFLKRNQYKQMIGRAGRAGIDTIGESILILQ
560 570 580 590 600 610
500 510 520 530 540 550
pF1KE2 NSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVG-GVASTSQDMHTYAAC
...:.. . :. ::...: .. : . : :.... ..: .:.. .:.. .
XP_005 EKDKQQVLELI---TKPLENCYSHLVQEFTKG--IQTLFLSLIGLKIATNLDDIYHFMNG
620 630 640 650 660 670
560 570 580 590 600 610
pF1KE2 TFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVY--HPTHL
::... .: . ...:. ..:. . .: :. ..:. . : : : :.:
XP_005 TFFGV-----QQKVLLKEKSLWEITVES-LRYLTEKGLLQKDTIYKSEEEVQYNFHITKL
680 690 700 710 720
620 630 640 650 660 670
pF1KE2 GSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPM-FEDWTTIDWYRFFCLW
: :....... : .. ::.....:.:::. ::..::.::. . . . ::. .: .
XP_005 GRASFKGTIDLAYCDILYRDLKKGLEGLVLESLLHLIYLTTPYDLVSQCNPDWMIYFRQF
730 740 750 760 770 780
680 690 700 710 720 730
pF1KE2 EKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVP
.: . . :: ..:: :.:... ..:..... .. . .:.. :.:: :..:.
XP_005 SQLSPAEQNVAAILGVSESFIGKKASGQAIGKKVDKN----VVNRLYLSFVLYTLLKETN
790 800 810 820 830 840
740 750 760 770 780 790
pF1KE2 LREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLG--WHNMELLLSQFQKRLTFGIQR
. ...:.. :: ::.: ..: ... . : ..: : .. :: .. :.::. ..
XP_005 IWTVSEKFNMPRGYIQNLLTGTASFSSCVLHFCEELEEFW-VYRALLVELTKKLTYCVKA
850 860 870 880 890 900
800 810 820 830 840 850
pF1KE2 ELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEE
:: :..:. . ::. ::..:.... :: :: :: : . . ..:.. :. .
XP_005 ELIPLMEVTGVLEGRAKQLYSAGYKSLMHLANANP-EVLVRTIDHLSRRQAKQIVSSAKM
910 920 930 940 950 960
860 870 880 890 900 910
pF1KE2 AVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALLHSSTCSL
..:.
XP_005 LLHEKAEALQEEVEELLRLPSDFPGAVASSTDKA
970 980 990
2590 residues in 1 query sequences
63842531 residues in 89799 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Feb 25 13:19:51 2018 done: Sun Feb 25 13:19:53 2018
Total Scan time: 11.760 Total Display time: 1.120
Function used was FASTA [36.3.4 Apr, 2011]