FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2758, 654 aa 1>>>pF1KE2758 654 - 654 aa - 654 aa Library: human.CCDS.faa 18921897 residues in 33420 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.9379+/-0.00123; mu= 5.7077+/- 0.075 mean_var=551.2697+/-111.752, 0's: 0 Z-trim(115.1): 180 B-trim: 0 in 0/56 Lambda= 0.054625 statistics sampled from 15652 (15824) to 15652 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.473), width: 16 Scan time: 2.050 The best scores are: opt bits E(33420) CCDS43258.1 COL25A1 gene_id:84570|Hs109|chr4 ( 654) 4805 393.8 4.2e-109 CCDS43259.1 COL25A1 gene_id:84570|Hs109|chr4 ( 642) 4497 369.5 8.4e-102 CCDS58922.1 COL25A1 gene_id:84570|Hs109|chr4 ( 645) 3242 270.6 5e-72 CCDS44424.2 COL13A1 gene_id:1305|Hs109|chr10 ( 695) 1558 137.9 4.6e-32 CCDS44423.2 COL13A1 gene_id:1305|Hs109|chr10 ( 668) 1552 137.4 6.3e-32 CCDS75932.1 COL5A1 gene_id:1289|Hs109|chr9 (1838) 1511 134.8 1e-30 CCDS6982.1 COL5A1 gene_id:1289|Hs109|chr9 (1838) 1511 134.8 1e-30 CCDS44425.2 COL13A1 gene_id:1305|Hs109|chr10 ( 686) 1487 132.3 2.2e-30 CCDS44428.2 COL13A1 gene_id:1305|Hs109|chr10 ( 610) 1478 131.5 3.4e-30 CCDS8759.1 COL2A1 gene_id:1280|Hs109|chr12 (1418) 1473 131.7 7.1e-30 CCDS41778.1 COL2A1 gene_id:1280|Hs109|chr12 (1487) 1473 131.7 7.3e-30 CCDS2773.1 COL7A1 gene_id:1294|Hs109|chr3 (2944) 1460 131.1 2.1e-29 CCDS12222.1 COL5A3 gene_id:50509|Hs109|chr19 (1745) 1436 128.9 6e-29 CCDS44427.2 COL13A1 gene_id:1305|Hs109|chr10 ( 645) 1411 126.3 1.4e-28 CCDS9511.1 COL4A1 gene_id:1282|Hs109|chr13 (1669) 1395 125.6 5.5e-28 CCDS42828.1 COL4A4 gene_id:1286|Hs109|chr2 (1690) 1389 125.2 7.7e-28 CCDS44419.1 COL13A1 gene_id:1305|Hs109|chr10 ( 717) 1376 123.6 9.8e-28 CCDS41353.1 COL24A1 gene_id:255631|Hs109|chr1 (1714) 1337 121.1 1.3e-26 CCDS4436.1 COL23A1 gene_id:91522|Hs109|chr5 ( 540) 1313 118.4 2.6e-26 CCDS6802.1 COL27A1 gene_id:85301|Hs109|chr9 (1860) 1299 118.2 1.1e-25 CCDS6376.1 COL22A1 gene_id:169044|Hs109|chr8 (1626) 1297 117.9 1.1e-25 CCDS13505.1 COL9A3 gene_id:1299|Hs109|chr20 ( 684) 1287 116.5 1.2e-25 CCDS35366.1 COL4A5 gene_id:1287|Hs109|chrX (1691) 1282 116.7 2.6e-25 CCDS41297.1 COL16A1 gene_id:1307|Hs109|chr1 (1604) 1269 115.7 5.2e-25 CCDS14542.1 COL4A6 gene_id:1288|Hs109|chrX (1690) 1261 115.1 8.3e-25 CCDS14541.1 COL4A6 gene_id:1288|Hs109|chrX (1691) 1261 115.1 8.3e-25 CCDS76010.1 COL4A6 gene_id:1288|Hs109|chrX (1707) 1261 115.1 8.4e-25 CCDS14543.1 COL4A5 gene_id:1287|Hs109|chrX (1685) 1251 114.3 1.4e-24 CCDS450.1 COL9A2 gene_id:1298|Hs109|chr1 ( 689) 1231 112.1 2.6e-24 CCDS76008.1 COL4A6 gene_id:1288|Hs109|chrX (1633) 1229 112.5 4.7e-24 CCDS76009.1 COL4A6 gene_id:1288|Hs109|chrX (1666) 1229 112.6 4.8e-24 CCDS11561.1 COL1A1 gene_id:1277|Hs109|chr17 (1464) 1213 111.2 1.1e-23 CCDS2297.1 COL3A1 gene_id:1281|Hs109|chr2 (1466) 1206 110.7 1.6e-23 CCDS41907.1 COL4A2 gene_id:1284|Hs109|chr13 (1712) 1171 108.0 1.1e-22 CCDS42971.1 COL18A1 gene_id:80781|Hs109|chr21 (1339) 1126 104.3 1.2e-21 CCDS42972.1 COL18A1 gene_id:80781|Hs109|chr21 (1519) 1126 104.4 1.3e-21 CCDS77643.1 COL18A1 gene_id:80781|Hs109|chr21 (1754) 1126 104.5 1.4e-21 CCDS7554.1 COL17A1 gene_id:1308|Hs109|chr10 (1497) 1087 101.3 1e-20 CCDS42829.1 COL4A3 gene_id:1285|Hs109|chr2 (1670) 1067 99.8 3.3e-20 CCDS4970.1 COL19A1 gene_id:1310|Hs109|chr6 (1142) 1008 94.9 6.8e-19 CCDS43553.1 COL28A1 gene_id:340267|Hs109|chr7 (1125) 952 90.5 1.4e-17 CCDS780.2 COL11A1 gene_id:1301|Hs109|chr1 (1690) 878 84.9 1e-15 CCDS53348.1 COL11A1 gene_id:1301|Hs109|chr1 (1767) 878 84.9 1e-15 CCDS778.1 COL11A1 gene_id:1301|Hs109|chr1 (1806) 878 85.0 1.1e-15 CCDS34682.1 COL1A2 gene_id:1278|Hs109|chr7 (1366) 855 83.0 3.2e-15 CCDS43452.1 COL11A2 gene_id:1302|Hs109|chr6 (1650) 839 81.8 8.4e-15 CCDS35081.1 COL15A1 gene_id:1306|Hs109|chr9 (1388) 837 81.5 8.6e-15 CCDS76649.1 COL4A1 gene_id:1282|Hs109|chr13 ( 519) 808 78.6 2.5e-14 CCDS33350.1 COL5A2 gene_id:1290|Hs109|chr2 (1499) 810 79.5 3.9e-14 CCDS55025.1 COL21A1 gene_id:81578|Hs109|chr6 ( 957) 777 76.6 1.9e-13 >>CCDS43258.1 COL25A1 gene_id:84570|Hs109|chr4 (654 aa) initn: 4805 init1: 4805 opt: 4805 Z-score: 2072.5 bits: 393.8 E(33420): 4.2e-109 Smith-Waterman score: 4805; 100.0% identity (100.0% similar) in 654 aa overlap (1-654:1-654) 10 20 30 40 50 60 pF1KE2 MLLKKHAGKGGGREPRSEDPTPAEQHCARTMPPCAVLAALLSVVAVVSCLYLGVKTNDLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 MLLKKHAGKGGGREPRSEDPTPAEQHCARTMPPCAVLAALLSVVAVVSCLYLGVKTNDLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ARIAALESAKGAPSIHLLPDTLDHLKTMVQEKVERLLAQKSYEHMAKIRIAREAPSECNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 ARIAALESAKGAPSIHLLPDTLDHLKTMVQEKVERLLAQKSYEHMAKIRIAREAPSECNC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKGDKGEQGDQGPRMVFPKINHGFLSADQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 PAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKGDKGEQGDQGPRMVFPKINHGFLSADQQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 LIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPRGMPGVPGEPGKPGEQGLMGPLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 LIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPRGMPGVPGEPGKPGEQGLMGPLG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 PPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGPKGEPGEQGEKGDAGENGPKGDTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 PPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGPKGEPGEQGEKGDAGENGPKGDTG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 EKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLPGLPGIKGEPGFIGPQGEPGLPGLPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 EKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLPGLPGIKGEPGFIGPQGEPGLPGLPGT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KGERGEAGPPGRGERGEPGAPGPKGKQGESGTRGPKGSKGDRGEKGDSGAQGPRGPPGQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 KGERGEAGPPGRGERGEPGAPGPKGKQGESGTRGPKGSKGDRGEKGDSGAQGPRGPPGQK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 GDQGATEIIDYNGNLHEALQRITTLTVTGPPGPPGPQGLQGPKGEQGSPGIPGMDGEQGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 GDQGATEIIDYNGNLHEALQRITTLTVTGPPGPPGPQGLQGPKGEQGSPGIPGMDGEQGL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 KGSKGDMGDPGMTGEKGGIGLPGLPGANGMKGEKGDSGMPGPQGPSIIGPPGPPGPHGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 KGSKGDMGDPGMTGEKGGIGLPGLPGANGMKGEKGDSGMPGPQGPSIIGPPGPPGPHGPP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 GPMGPHGLPGPKGTDGPMGPHGPAGPKGERGEKGAMGEPGPRGPYGLPGKDGEPGLDGFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 GPMGPHGLPGPKGTDGPMGPHGPAGPKGERGEKGAMGEPGPRGPYGLPGKDGEPGLDGFP 550 560 570 580 590 600 610 620 630 640 650 pF1KE2 GPRGEKGDLGEKGEKGFRGVKGEKGEPGQPGLDGLDAPCQLGPDGLPMPGCWQK :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 GPRGEKGDLGEKGEKGFRGVKGEKGEPGQPGLDGLDAPCQLGPDGLPMPGCWQK 610 620 630 640 650 >>CCDS43259.1 COL25A1 gene_id:84570|Hs109|chr4 (642 aa) initn: 4497 init1: 4497 opt: 4497 Z-score: 1941.4 bits: 369.5 E(33420): 8.4e-102 Smith-Waterman score: 4497; 100.0% identity (100.0% similar) in 615 aa overlap (1-615:1-615) 10 20 30 40 50 60 pF1KE2 MLLKKHAGKGGGREPRSEDPTPAEQHCARTMPPCAVLAALLSVVAVVSCLYLGVKTNDLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 MLLKKHAGKGGGREPRSEDPTPAEQHCARTMPPCAVLAALLSVVAVVSCLYLGVKTNDLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ARIAALESAKGAPSIHLLPDTLDHLKTMVQEKVERLLAQKSYEHMAKIRIAREAPSECNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 ARIAALESAKGAPSIHLLPDTLDHLKTMVQEKVERLLAQKSYEHMAKIRIAREAPSECNC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKGDKGEQGDQGPRMVFPKINHGFLSADQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 PAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKGDKGEQGDQGPRMVFPKINHGFLSADQQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 LIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPRGMPGVPGEPGKPGEQGLMGPLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 LIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPRGMPGVPGEPGKPGEQGLMGPLG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 PPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGPKGEPGEQGEKGDAGENGPKGDTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 PPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGPKGEPGEQGEKGDAGENGPKGDTG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 EKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLPGLPGIKGEPGFIGPQGEPGLPGLPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 EKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLPGLPGIKGEPGFIGPQGEPGLPGLPGT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KGERGEAGPPGRGERGEPGAPGPKGKQGESGTRGPKGSKGDRGEKGDSGAQGPRGPPGQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 KGERGEAGPPGRGERGEPGAPGPKGKQGESGTRGPKGSKGDRGEKGDSGAQGPRGPPGQK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 GDQGATEIIDYNGNLHEALQRITTLTVTGPPGPPGPQGLQGPKGEQGSPGIPGMDGEQGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 GDQGATEIIDYNGNLHEALQRITTLTVTGPPGPPGPQGLQGPKGEQGSPGIPGMDGEQGL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 KGSKGDMGDPGMTGEKGGIGLPGLPGANGMKGEKGDSGMPGPQGPSIIGPPGPPGPHGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 KGSKGDMGDPGMTGEKGGIGLPGLPGANGMKGEKGDSGMPGPQGPSIIGPPGPPGPHGPP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 GPMGPHGLPGPKGTDGPMGPHGPAGPKGERGEKGAMGEPGPRGPYGLPGKDGEPGLDGFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 GPMGPHGLPGPKGTDGPMGPHGPAGPKGERGEKGAMGEPGPRGPYGLPGKDGEPGLDGFP 550 560 570 580 590 600 610 620 630 640 650 pF1KE2 GPRGEKGDLGEKGEKGFRGVKGEKGEPGQPGLDGLDAPCQLGPDGLPMPGCWQK ::::::::::::::: CCDS43 GPRGEKGDLGEKGEKVTSPSQHVPCLILLLLSALLFSLCDSI 610 620 630 640 >>CCDS58922.1 COL25A1 gene_id:84570|Hs109|chr4 (645 aa) initn: 3269 init1: 1584 opt: 3242 Z-score: 1406.8 bits: 270.6 E(33420): 5e-72 Smith-Waterman score: 3941; 86.1% identity (86.9% similar) in 656 aa overlap (1-615:1-618) 10 20 30 40 50 60 pF1KE2 MLLKKHAGKGGGREPRSEDPTPAEQHCARTMPPCAVLAALLSVVAVVSCLYLGVKTNDLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 MLLKKHAGKGGGREPRSEDPTPAEQHCARTMPPCAVLAALLSVVAVVSCLYLGVKTNDLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ARIAALESAKGAPSIHLLPDTLDHLKTMVQEKVERLLAQKSYEHMAKIRIAREAPSECNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 ARIAALESAKGAPSIHLLPDTLDHLKTMVQEKVERLLAQKSYEHMAKIRIAREAPSECNC 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 PAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKGDKGEQGDQGPRMV--FPKINHGFLSAD :::::::::::::::::::::::::::::::::::::::::::: . :: . : .. CCDS58 PAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKGDKGEQGDQGPRGLPGFPTVAA--LHSN 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 QQLIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPRGMPGVPGEPGKPGEQGLMGP : : .::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 QILT----VKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPRGMPGVPGEPGKPGEQGLMGP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 LGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGPKGEPGEQGEKGDAGENGPKGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 LGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGPKGEPGEQGEKGDAGENGPKGD 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 TGEKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLPGLPGIKGEPGFIGPQGEPGLPGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 TGEKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLPGLPGIKGEPGFIGPQGEPGLPGLP 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 GTKGERGEAGPPGRGERGEPGAPGPKGKQGESGTRGPKGSKGDRGEKGDSGAQGPRGPPG ::::::::::::::::::::::::::: :::::::::::::::::: CCDS58 GTKGERGEAGPPGRGERGEPGAPGPKG---------------DRGEKGDSGAQGPRGPPG 360 370 380 390 420 430 440 450 460 470 pF1KE2 QKGDQGATEIIDYNGNLHEALQRITTLTVTGPPGPPGPQGLQGPKGEQGSPGIPGMDGEQ :::::::::::::::::::::: :::::::::::::::::::::::::::::: CCDS58 QKGDQGATEIIDYNGNLHEALQ--------GPPGPPGPQGLQGPKGEQGSPGIPGMDGEQ 400 410 420 430 440 450 480 490 500 510 520 530 pF1KE2 GLKGSKGDMGDPGMTGEKGGIGLPGLPGANGMKGEKGDSGMPGPQGPSIIGPPGPPGPHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 GLKGSKGDMGDPGMTGEKGGIGLPGLPGANGMKGEKGDSGMPGPQGPSIIGPPGPPGPHG 460 470 480 490 500 510 540 550 pF1KE2 PPGPMGPHGLPGPKG---------------------------------------TDGPMG ::::::::::::::: :::::: CCDS58 PPGPMGPHGLPGPKGEPGLNGVKGLKGEPGQKGDRGPLGLPGASGLDGKPGSRGTDGPMG 520 530 540 550 560 570 560 570 580 590 600 610 pF1KE2 PHGPAGPKGERGEKGAMGEPGPRGPYGLPGKDGEPGLDGFPGPRGEKGDLGEKGEKGFRG :::::::::::::::::::::::::::::: ::::::::::::::::: CCDS58 PHGPAGPKGERGEKGAMGEPGPRGPYGLPG---------FPGPRGEKGDLGEKGEKVTSP 580 590 600 610 620 620 630 640 650 pF1KE2 VKGEKGEPGQPGLDGLDAPCQLGPDGLPMPGCWQK CCDS58 SQHVPCLILLLLSALLFSLCDSI 630 640 >>CCDS44424.2 COL13A1 gene_id:1305|Hs109|chr10 (695 aa) initn: 4103 init1: 944 opt: 1558 Z-score: 689.3 bits: 137.9 E(33420): 4.6e-32 Smith-Waterman score: 1651; 43.0% identity (57.0% similar) in 691 aa overlap (28-644:37-685) 10 20 30 40 50 pF1KE2 MLLKKHAGKGGGREPRSEDPTPAEQHCARTMPP--CAVLAALLSVVAVVSCLYLGVK :: : :..:. : .:. : . CCDS44 HKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLAL--SLLAHFR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 TNDLQARIAALESAKGAPSIHLLPDTLDHLKTMVQEKVERLLAQKSYEHMAKIRIAREAP : .::::. ::. .: ....: . .:..:: .: : . : : .. CCDS44 TAELQARVLRLEAERGE----------QQMETAILGRVNQLLDEKWKLHSRRRREAPKTS 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 SECNCPAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKG-----DKGEQGDQGPRMVFPKI :::: :::: :. : :..: :.:: : :: : .: :. : : :: . CCDS44 PGCNCPPGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRG-FPGF 120 130 140 150 160 170 180 190 200 210 220 pF1KE2 NHGFLSADQQLIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPR----GMPG---- : .. : . . :::.: .:::: ::: : .: :. :. : .::. CCDS44 P-GPIGLDGK-PGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRS 180 190 200 210 220 230 230 240 250 260 270 pF1KE2 -----VPGEPGKPGEQGLMGPLGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGP . :: .. . :: :: :::: .: .: ::.:: : ::::: ::: CCDS44 SQIIALKGEQSQASIQGPPGPPGPPGPSGPLGHPGLPG---PMGPPGLPGP------PGP 240 250 260 270 280 280 290 300 310 320 330 pF1KE2 KGEPGEQGEKGDAGENG-P--KGDTGEKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLP ::.:: :: .: :: : : : : :: :: ..::.::::: : :.:: : :::: CCDS44 KGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGSPGLP 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE2 GLPGIKGEPGFIGPQGEPGLPGLPGTKGERGEAGPPGRGERGEPGAPGPKGKQGESGTRG :: : ::: .:. : . : ::: :::: :: :::::. : .: : CCDS44 GLLGQKGE------KGDAG----NSIGGGRGEPGPPGL-----PGPPGPKGEAGVDGQVG 350 360 370 380 400 410 420 430 440 450 pF1KE2 PKGSKGDRGEKGDSGAQGPRGPPGQKGDQGATEIIDYNGNLHEALQRITTLTVTGPPG-- : :. ::.::.: .: ::: :: :.::. : :..:::::..::::.: ::.. :::: CCDS44 PPGQPGDKGERGAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLP 390 400 410 420 430 440 460 470 480 490 pF1KE2 ----PPGPQGLQGPKGEQGSPGIPGMDGEQGLKGSKGDMGDPGMTGEKG-----GI---- ::: :. : ::: : :: :: :::.: .:. :::: :: : : :. CCDS44 GQIGPPGAPGIPGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGEN 450 460 470 480 490 500 500 510 520 530 540 550 pF1KE2 GLPGLPGANGMKGEKGDSGMPGPQGPSI-IGPPG---P--PGPHGPPGPMGPHGLPGPKG : :: :: .: ::: :..: :: .: . : :: : :::.::::: : .:.::::: CCDS44 GHPGSPGEKGEKGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKG 510 520 530 540 550 560 560 570 580 590 pF1KE2 T---DGPMGPHGPAGPKGERGE------------------KGAMGEPGPRGPYGLPGKDG :: : .: : ::.:: : .: ::: :: : :. : CCDS44 EAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKG 570 580 590 600 610 620 600 610 620 630 640 pF1KE2 EPGLDG------FPG---PRGEKGDLGEKGEKGFRGVKGEKGEPGQPGLDGLDAPCQLGP .::. : .:: : :.::. ::.:.:: :: ::.::. : :: ::::: :: CCDS44 DPGMTGPTGAAGLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPG---LDAPCPLGE 630 640 650 660 670 680 650 pF1KE2 DGLPMPGCWQK : CCDS44 DGLPVQGCWNK 690 >>CCDS44423.2 COL13A1 gene_id:1305|Hs109|chr10 (668 aa) initn: 4618 init1: 1048 opt: 1552 Z-score: 686.9 bits: 137.4 E(33420): 6.3e-32 Smith-Waterman score: 1761; 44.5% identity (58.5% similar) in 674 aa overlap (28-654:37-668) 10 20 30 40 50 pF1KE2 MLLKKHAGKGGGREPRSEDPTPAEQHCARTMPP--CAVLAALLSVVAVVSCLYLGVK :: : :..:. : .:. : . CCDS44 HKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLAL--SLLAHFR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 TNDLQARIAALESAKGAPSIHLLPDTLDHLKTMVQEKVERLLAQKSYEHMAKIRIAREAP : .::::. ::. .: ....: . .:..:: .: : . : : .. CCDS44 TAELQARVLRLEAERGE----------QQMETAILGRVNQLLDEKWKLHSRRRREAPKTS 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 SECNCPAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKG-----DKGEQGDQGPRMVFPKI :::: :::: :. : :..: :.:: : :: : .: :. : : :: . CCDS44 PGCNCPPGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRG-FPGF 120 130 140 150 160 170 180 190 200 210 220 pF1KE2 NHGFLSADQQLIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPR----GMPG---- : .. : . . :::.: .:::: ::: : .: :. :. : .::. CCDS44 P-GPIGLDGK-PGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRS 180 190 200 210 220 230 230 240 250 260 270 pF1KE2 -----VPGEPGKPGEQGLMGPLGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGP . :: .. . :: :: :::: .: .: ::.:: : ::::: ::: CCDS44 SQIIALKGEQSQASIQGPPGPPGPPGPSGPLGHPGLPG---PMGPPGLPGP------PGP 240 250 260 270 280 280 290 300 310 320 330 pF1KE2 KGEPGEQGEKGDAGENG-P--KGDTGEKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLP ::.:: :: .: :: : : : : :: :: ..::.::::: : :.:: : :::: CCDS44 KGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGSPGLP 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE2 GLPGIKGEPGFIGPQGEPGLPGLPGTKGERGEAGPPGRGERGEPGAPGPKGKQGESGTRG :: : ::: : : . : ::: :::: :: :::::. : .: : CCDS44 GLLGQKGEKGDAGNS----------IGGGRGEPGPPGL-----PGPPGPKGEAGVDGQVG 350 360 370 380 400 410 420 430 440 450 pF1KE2 PKGSKGDRGEKGDSGAQGPRGPPGQKGDQGATEIIDYNGNLHEALQRITTLTVTGPPG-- : :. ::.::.: .: ::: :: :.::. : :..:::::..::::.: ::.. :::: CCDS44 PPGQPGDKGERGAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLP 390 400 410 420 430 440 460 470 480 490 pF1KE2 ----PPGPQGLQGPKGEQGSPGIPGMDGEQGLKGSKGDMGDPGMTGEKG-----GI---- ::: :. : ::: : :: :: :::.: .:. :::: :: : : :. CCDS44 GQIGPPGAPGIPGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGEN 450 460 470 480 490 500 500 510 520 530 540 550 pF1KE2 GLPGLPGANGMKGEKGDSGMPGPQGPSIIGPPGPPGPHGPPGPMGPHGLPGPKGTDGPMG : :: :: .: ::: :..: : : :. ::::::: .: ::: : :: : :: : .: CCDS44 GHPGSPGEKGEKGETGQAGSPVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEKGFQG 510 520 530 540 550 560 560 570 580 590 600 610 pF1KE2 PHGPAGPKGERGEKGAMGEPGPRGPYGLPGKDGEPGLDG------FPG---PRGEKGDLG .: :: : : : .: ::: :: : :. :.::. : .:: : :.::. : CCDS44 EKGDRGPLGLPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGLHGPPGDKGNRG 570 580 590 600 610 620 620 630 640 650 pF1KE2 EKGEKGFRGVKGEKGEPGQPGLDGLDAPCQLGPDGLPMPGCWQK :.:.:: :: ::.::. : :: ::::: :: ::::. :::.: CCDS44 ERGKKGSRGPKGDKGDQGAPG---LDAPCPLGEDGLPVQGCWNK 630 640 650 660 >>CCDS75932.1 COL5A1 gene_id:1289|Hs109|chr9 (1838 aa) initn: 2556 init1: 562 opt: 1511 Z-score: 665.1 bits: 134.8 E(33420): 1e-30 Smith-Waterman score: 1539; 43.7% identity (56.7% similar) in 600 aa overlap (113-649:474-1067) 90 100 110 120 130 140 pF1KE2 DHLKTMVQEKVERLLAQKSYEHMAKIRIAREAPSECNCPAGPPGKRGKRGRRGESGPPGQ :.:. : : : :. : :: ::::. CCDS75 GIGGPRGEKGQKGEPAIIEPGMLIEGPPGPEGPAGLPGPPGTMGPTGQVGDPGERGPPGR 450 460 470 480 490 500 150 160 170 180 pF1KE2 PG-P-----QGPPGPK-------GDKGEQGDQGPRMVFPKINHGFLSADQQLIKRRLIKG :: : :::: : :. :..:: :: . ... .: . : : CCDS75 PGLPGADGLPGPPGTMLMLPFRFGGGGDAGSKGP-MVSAQESQAQAILQQARLALRGPAG 510 520 530 540 550 560 190 200 210 220 230 pF1KE2 DQGQAGPPGPPGPPGP---RGPPGDTGKDGPRGMPGVPGEPGKPGEQG---------LMG .: .: ::: :::: .: :::.: .::::. : :: ::::..: . : CCDS75 PMGLTGRPGPVGPPGSGGLKGEPGDVGPQGPRGVQGPPGPAGKPGRRGRAGSDGARGMPG 570 580 590 600 610 620 240 250 260 270 280 290 pF1KE2 PLGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGPKGEPGEQGEKGDAGENGPKG :: :..: : :.:: .:..:.:: : : : : .:. :: : .: :: ::.: CCDS75 QTGPKGDRGFDGLAGLPGEKGHRGDPGPSGPPGPPGDDGERGDDGEVGPRGLPGEPGPRG 630 640 650 660 670 680 300 310 320 330 340 pF1KE2 DTGEKGDPGS----SAAGIKGEPG---------ESGRPGQKGEPGLPGLPGLPGIKGEPG : :: :: ...:. :.:: : : :::.:.:: :::: : : :: CCDS75 LLGPKGPPGPPGPPGVTGMDGQPGPKGNVGPQGEPGPPGQQGNPGAQGLPGPQGAIGPPG 690 700 710 720 730 740 350 360 370 380 390 400 pF1KE2 FIGPQGEPGLPGLPGTKG---ERGEAGPPGRGERGEPGAPGPKGKQGESGTRGPKGSKGD :: :.:::::.::. : . :. :::: :.: : :::.: : : :: ::. : CCDS75 EKGPLGKPGLPGMPGADGPPGHPGKEGPPG--EKGGQGPPGPQGPIGYPGPRGVKGADGI 750 760 770 780 790 800 410 420 430 440 450 pF1KE2 RGEKGDSGAQGPRGPPGQKGDQGATEIIDYNGNLHEALQRITTLTVT-----GPPGPPGP :: :: .: .: : :: :::.: : :.. : :: : ::: CCDS75 RGLKGTKGEKGEDGFPGFKGDMG---IKGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPGP 810 820 830 840 850 460 470 480 490 500 510 pF1KE2 QGLQGPKGEQGSPGIPGMDGEQGLKGSKGDMGDPGMTGEKGGIGLPGLPGANGMKG---- : : ::. : ::.::. :.:: ::: : : :: .::::: : :: :: :..: CCDS75 LGPPGEKGKLGVPGLPGYPGRQGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQRGPTGP 860 870 880 890 900 910 520 530 540 550 560 pF1KE2 --EKGDSGM---PGPQGPSII-GPPGPPGPHGPPGPMGPHGLPGPKGTDGPMGPHGPAGP :.: :. :::.: : :: :::: .:: ::.:: :.::::: :: : : : CCDS75 RGERGPRGITGKPGPKGNSGGDGPAGPPGERGPNGPQGPTGFPGPKGPPGPPGKDGLPGH 920 930 940 950 960 970 570 580 590 600 610 620 pF1KE2 KGERGEKGAMGEPGPRGPYGLPGKDGEPGLDGFPGPRGEKGDLGEKGEKGFRGVKGE--- :.::: : .:. :: :: :. : .: : : : ::. : : ::.:. :. :. CCDS75 PGQRGETGFQGKTGPPGPPGVVGPQGPTGETGPMGERGHPGPPGPPGEQGLPGLAGKEGT 980 990 1000 1010 1020 1030 630 640 650 pF1KE2 KGEPGQPGLDGLDAPCQL----GPDGLPMPGCWQK ::.:: :: : :.: : : ::: : CCDS75 KGDPGPAGLPGKDGPPGLRGFPGDRGLPGPVGALGLKGNEGPPGPPGPAGSPGERGPAGA 1040 1050 1060 1070 1080 1090 >-- initn: 2506 init1: 561 opt: 889 Z-score: 400.2 bits: 85.8 E(33420): 5.8e-16 Smith-Waterman score: 1402; 46.9% identity (57.5% similar) in 475 aa overlap (123-594:1162-1575) 100 110 120 130 140 150 pF1KE2 VERLLAQKSYEHMAKIRIAREAPSECNCPAGPPGKRGKRGRRGESGPPGQPGPQGPPGPK : ::..:..: .::.:::: ::::: : CCDS75 GRDGLQGPVGLPGPAGPVGPPGEDGDKGEIGEPGQKGSKGDKGEQGPPGPTGPQGPIGQP 1140 1150 1160 1170 1180 1190 160 170 180 190 200 210 pF1KE2 GDKGEQGDQGPRMVFPKINHGFLSADQQLIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDT : .: .:. ::: ..: :. :..:. :: : :::::: : CCDS75 GPSGADGEPGPR------------GQQGLF------GQKGDEGPRGFPGPPGPVGL---- 1200 1210 1220 220 230 240 250 260 270 pF1KE2 GKDGPRGMPGVPGEPGKPGEQGLMGPLGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQN .:.:: ::: :. :. : ::: :::: .: :::: : .: : : :::::.. CCDS75 -----QGLPGPPGEKGETGDVGQMGPPGPPGPRGPSGAPGADGPQGPPGGIGNPGAVGEK 1230 1240 1250 1260 1270 1280 280 290 300 310 320 330 pF1KE2 GIPGPKGEPGEQGEKGDAGENGPKGDTGEKGDPGSSAAGIKGEPGESGRPGQKGEPGLPG : :: :::: :: .: ::::. ::::. : : : : :: .: ::. : : :: CCDS75 GEPGEAGEPGLPGE---GGPPGPKGERGEKGESGPS--GAAGPPGPKGPPGDDGPKGSPG 1290 1300 1310 1320 1330 340 350 360 370 380 390 pF1KE2 LPGLPGIKGEPGFIGPQGEPGLPGLPGTKGERGEAGPPGRGERGEPGAPGPKGKQGESGT :.:: : :: :: :. : :: : :: :..: : : :::: :: ::.: : CCDS75 PVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSP--GPTGEPGPSGPPGKRGPPGP 1340 1350 1360 1370 1380 1390 400 410 420 430 440 450 pF1KE2 RGPKGSKGDRGEKGDSGAQGPRGPPGQKGDQGATEIIDYNGNLHEALQRITTLTVTGPPG ::.: .:..: ::..: .:: : : : ::: : :: CCDS75 AGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAP----------------------GKPG 1400 1410 1420 1430 460 470 480 490 500 pF1KE2 PPGPQGLQGPKGEQGSPGIPGMDGEQGLKGSKGD---MGDPGMTGEKGGIGLPGLPGANG : : .:. :: :::: :: :: :: : : : :: : :::: :: :: : : CCDS75 PDGLRGIPGPVGEQGLPGSPGPDGPPGPMGPPGLPGLKGDSGPKGEKGHPGLIGLIGPPG 1440 1450 1460 1470 1480 1490 510 520 530 540 550 560 pF1KE2 MKGEKGDSGMPGPQGPSIIGPPGPPGPHGPPGPMGPHGLPGPKGTDGPMGPHGPAGPKGE .::::: :.::::: : :: : : :: ::.:: ::: : :: ::.: : .: CCDS75 EQGEKGDRGLPGPQGSS--GPKGEQGITGPSGPIGP---PGPPGLPGPPGPKGAKGSSGP 1500 1510 1520 1530 1540 1550 570 580 590 600 610 620 pF1KE2 RGEKGAMGEPGPRGPYGLPGKDGEPGLDGFPGPRGEKGDLGEKGEKGFRGVKGEKGEPGQ : :: :.::: :: : ::. .: CCDS75 TGPKGEAGHPGPPGPPGPPGEVIQPLPIQASRTRRNIDASQLLDDGNGENYVDYADGMEE 1560 1570 1580 1590 1600 1610 >>CCDS6982.1 COL5A1 gene_id:1289|Hs109|chr9 (1838 aa) initn: 2556 init1: 562 opt: 1511 Z-score: 665.1 bits: 134.8 E(33420): 1e-30 Smith-Waterman score: 1539; 43.7% identity (56.7% similar) in 600 aa overlap (113-649:474-1067) 90 100 110 120 130 140 pF1KE2 DHLKTMVQEKVERLLAQKSYEHMAKIRIAREAPSECNCPAGPPGKRGKRGRRGESGPPGQ :.:. : : : :. : :: ::::. CCDS69 GIGGPRGEKGQKGEPAIIEPGMLIEGPPGPEGPAGLPGPPGTMGPTGQVGDPGERGPPGR 450 460 470 480 490 500 150 160 170 180 pF1KE2 PG-P-----QGPPGPK-------GDKGEQGDQGPRMVFPKINHGFLSADQQLIKRRLIKG :: : :::: : :. :..:: :: . ... .: . : : CCDS69 PGLPGADGLPGPPGTMLMLPFRFGGGGDAGSKGP-MVSAQESQAQAILQQARLALRGPAG 510 520 530 540 550 560 190 200 210 220 230 pF1KE2 DQGQAGPPGPPGPPGP---RGPPGDTGKDGPRGMPGVPGEPGKPGEQG---------LMG .: .: ::: :::: .: :::.: .::::. : :: ::::..: . : CCDS69 PMGLTGRPGPVGPPGSGGLKGEPGDVGPQGPRGVQGPPGPAGKPGRRGRAGSDGARGMPG 570 580 590 600 610 620 240 250 260 270 280 290 pF1KE2 PLGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGPKGEPGEQGEKGDAGENGPKG :: :..: : :.:: .:..:.:: : : : : .:. :: : .: :: ::.: CCDS69 QTGPKGDRGFDGLAGLPGEKGHRGDPGPSGPPGPPGDDGERGDDGEVGPRGLPGEPGPRG 630 640 650 660 670 680 300 310 320 330 340 pF1KE2 DTGEKGDPGS----SAAGIKGEPG---------ESGRPGQKGEPGLPGLPGLPGIKGEPG : :: :: ...:. :.:: : : :::.:.:: :::: : : :: CCDS69 LLGPKGPPGPPGPPGVTGMDGQPGPKGNVGPQGEPGPPGQQGNPGAQGLPGPQGAIGPPG 690 700 710 720 730 740 350 360 370 380 390 400 pF1KE2 FIGPQGEPGLPGLPGTKG---ERGEAGPPGRGERGEPGAPGPKGKQGESGTRGPKGSKGD :: :.:::::.::. : . :. :::: :.: : :::.: : : :: ::. : CCDS69 EKGPLGKPGLPGMPGADGPPGHPGKEGPPG--EKGGQGPPGPQGPIGYPGPRGVKGADGI 750 760 770 780 790 800 410 420 430 440 450 pF1KE2 RGEKGDSGAQGPRGPPGQKGDQGATEIIDYNGNLHEALQRITTLTVT-----GPPGPPGP :: :: .: .: : :: :::.: : :.. : :: : ::: CCDS69 RGLKGTKGEKGEDGFPGFKGDMG---IKGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPGP 810 820 830 840 850 460 470 480 490 500 510 pF1KE2 QGLQGPKGEQGSPGIPGMDGEQGLKGSKGDMGDPGMTGEKGGIGLPGLPGANGMKG---- : : ::. : ::.::. :.:: ::: : : :: .::::: : :: :: :..: CCDS69 LGPPGEKGKLGVPGLPGYPGRQGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQRGPTGP 860 870 880 890 900 910 520 530 540 550 560 pF1KE2 --EKGDSGM---PGPQGPSII-GPPGPPGPHGPPGPMGPHGLPGPKGTDGPMGPHGPAGP :.: :. :::.: : :: :::: .:: ::.:: :.::::: :: : : : CCDS69 RGERGPRGITGKPGPKGNSGGDGPAGPPGERGPNGPQGPTGFPGPKGPPGPPGKDGLPGH 920 930 940 950 960 970 570 580 590 600 610 620 pF1KE2 KGERGEKGAMGEPGPRGPYGLPGKDGEPGLDGFPGPRGEKGDLGEKGEKGFRGVKGE--- :.::: : .:. :: :: :. : .: : : : ::. : : ::.:. :. :. CCDS69 PGQRGETGFQGKTGPPGPPGVVGPQGPTGETGPMGERGHPGPPGPPGEQGLPGLAGKEGT 980 990 1000 1010 1020 1030 630 640 650 pF1KE2 KGEPGQPGLDGLDAPCQL----GPDGLPMPGCWQK ::.:: :: : :.: : : ::: : CCDS69 KGDPGPAGLPGKDGPPGLRGFPGDRGLPGPVGALGLKGNEGPPGPPGPAGSPGERGPAGA 1040 1050 1060 1070 1080 1090 >-- initn: 2506 init1: 561 opt: 889 Z-score: 400.2 bits: 85.8 E(33420): 5.8e-16 Smith-Waterman score: 1402; 46.9% identity (57.5% similar) in 475 aa overlap (123-594:1162-1575) 100 110 120 130 140 150 pF1KE2 VERLLAQKSYEHMAKIRIAREAPSECNCPAGPPGKRGKRGRRGESGPPGQPGPQGPPGPK : ::..:..: .::.:::: ::::: : CCDS69 GRDGLQGPVGLPGPAGPVGPPGEDGDKGEIGEPGQKGSKGDKGEQGPPGPTGPQGPIGQP 1140 1150 1160 1170 1180 1190 160 170 180 190 200 210 pF1KE2 GDKGEQGDQGPRMVFPKINHGFLSADQQLIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDT : .: .:. ::: ..: :. :..:. :: : :::::: : CCDS69 GPSGADGEPGPR------------GQQGLF------GQKGDEGPRGFPGPPGPVGL---- 1200 1210 1220 220 230 240 250 260 270 pF1KE2 GKDGPRGMPGVPGEPGKPGEQGLMGPLGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQN .:.:: ::: :. :. : ::: :::: .: :::: : .: : : :::::.. CCDS69 -----QGLPGPPGEKGETGDVGQMGPPGPPGPRGPSGAPGADGPQGPPGGIGNPGAVGEK 1230 1240 1250 1260 1270 1280 280 290 300 310 320 330 pF1KE2 GIPGPKGEPGEQGEKGDAGENGPKGDTGEKGDPGSSAAGIKGEPGESGRPGQKGEPGLPG : :: :::: :: .: ::::. ::::. : : : : :: .: ::. : : :: CCDS69 GEPGEAGEPGLPGE---GGPPGPKGERGEKGESGPS--GAAGPPGPKGPPGDDGPKGSPG 1290 1300 1310 1320 1330 340 350 360 370 380 390 pF1KE2 LPGLPGIKGEPGFIGPQGEPGLPGLPGTKGERGEAGPPGRGERGEPGAPGPKGKQGESGT :.:: : :: :: :. : :: : :: :..: : : :::: :: ::.: : CCDS69 PVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSP--GPTGEPGPSGPPGKRGPPGP 1340 1350 1360 1370 1380 1390 400 410 420 430 440 450 pF1KE2 RGPKGSKGDRGEKGDSGAQGPRGPPGQKGDQGATEIIDYNGNLHEALQRITTLTVTGPPG ::.: .:..: ::..: .:: : : : ::: : :: CCDS69 AGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAP----------------------GKPG 1400 1410 1420 1430 460 470 480 490 500 pF1KE2 PPGPQGLQGPKGEQGSPGIPGMDGEQGLKGSKGD---MGDPGMTGEKGGIGLPGLPGANG : : .:. :: :::: :: :: :: : : : :: : :::: :: :: : : CCDS69 PDGLRGIPGPVGEQGLPGSPGPDGPPGPMGPPGLPGLKGDSGPKGEKGHPGLIGLIGPPG 1440 1450 1460 1470 1480 1490 510 520 530 540 550 560 pF1KE2 MKGEKGDSGMPGPQGPSIIGPPGPPGPHGPPGPMGPHGLPGPKGTDGPMGPHGPAGPKGE .::::: :.::::: : :: : : :: ::.:: ::: : :: ::.: : .: CCDS69 EQGEKGDRGLPGPQGSS--GPKGEQGITGPSGPIGP---PGPPGLPGPPGPKGAKGSSGP 1500 1510 1520 1530 1540 1550 570 580 590 600 610 620 pF1KE2 RGEKGAMGEPGPRGPYGLPGKDGEPGLDGFPGPRGEKGDLGEKGEKGFRGVKGEKGEPGQ : :: :.::: :: : ::. .: CCDS69 TGPKGEAGHPGPPGPPGPPGEVIQPLPIQASRTRRNIDASQLLDDGNGENYVDYADGMEE 1560 1570 1580 1590 1600 1610 >>CCDS44425.2 COL13A1 gene_id:1305|Hs109|chr10 (686 aa) initn: 2495 init1: 939 opt: 1487 Z-score: 659.1 bits: 132.3 E(33420): 2.2e-30 Smith-Waterman score: 1704; 43.3% identity (57.7% similar) in 691 aa overlap (28-650:37-682) 10 20 30 40 50 pF1KE2 MLLKKHAGKGGGREPRSEDPTPAEQHCARTMPP--CAVLAALLSVVAVVSCLYLGVK :: : :..:. : .:. : . CCDS44 HKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLAL--SLLAHFR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 TNDLQARIAALESAKGAPSIHLLPDTLDHLKTMVQEKVERLLAQKSYEHMAKIRIAREAP : .::::. ::. .: ....: . .:..:: .: : . : : .. CCDS44 TAELQARVLRLEAERGE----------QQMETAILGRVNQLLDEKWKLHSRRRREAPKTS 70 80 90 100 110 120 130 140 150 160 pF1KE2 SECNCPAGPPGKRGKRGRRGESGPPGQPGPQGPPG--------PKGDKGEQGDQGPRMVF :::: :::: :. : :..: :.:: : :: :.: :. : .: : CCDS44 PGCNCPPGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRG----F 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 PKINHGFLSADQQLIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPRGMPGV---- : . : .. : . . :::.: .:::: ::: : .: :. :. : .: . CCDS44 PGFP-GPIGLDGK-PGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRLLPLLNSVR 180 190 200 210 220 230 240 250 260 270 pF1KE2 --P----------GEPGKPGEQGLMGPLGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQ : :: .. . :: :: :::: .: .: ::.:: : ::::: CCDS44 LAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPG---PMGPPGLPGP--- 230 240 250 260 270 280 280 290 300 310 320 pF1KE2 NGIPGPKGEPGEQGEKGDAGENG-P--KGDTGEKGDPGSSAAGIKGEPGESGRPGQKGEP :::::.:: :: .: :: : : : : :: :: ..::.::::: : :.:: CCDS44 ---PGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAE 290 300 310 320 330 330 340 350 360 370 380 pF1KE2 GLPGLPGLPGIKGEPGFIGPQGEPGLPGLPGTKGERGEAGPPGRGERGEPGAPGPKGKQG : :::::: : ::: : : . : ::: :::: :: :::::. : CCDS44 GSPGLPGLLGQKGEKGDAG----------NSIGGGRGEPGPPGL-----PGPPGPKGEAG 340 350 360 370 380 390 400 410 420 430 440 pF1KE2 ESGTRGPKGSKGDRGEKGDSGAQGPRGPPGQKGDQGATEIIDYNGNLHEALQRITTLTVT .: :: :. ::.::.: .: ::: :: :.::. : :..:::::..::::.: ::.. CCDS44 VDGQVGPPGQPGDKGERGAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALM 390 400 410 420 430 440 450 460 470 480 490 pF1KE2 GPPG------PPGPQGLQGPKGEQGSPGIPGMDGEQGLKGSKGDMGDPGMTGEKG----- :::: ::: :. : ::: : :: :: :::.: .:. :::: :: : : CCDS44 GPPGLPGQIGPPGAPGIPGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPP 450 460 470 480 490 500 500 510 520 530 540 pF1KE2 GI----GLPGLPGANGMKGEKGDSGMPGPQGPSI-IGPPG---P--PGPHGPPGPMGPHG :. : :: :: .: ::: :..: :: .: . : :: : :::.::::: : .: CCDS44 GVKGENGHPGSPGEKGEKGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQG 510 520 530 540 550 560 550 560 570 580 590 pF1KE2 LPGPKGTDGPMGPHGPAGPKGERGEKGAMGEPGPRGPYGLPG---------KDGEPGLDG .::::: : : .: : .::.:..: .: :: :: :.:: . :.::. : CCDS44 VPGPKGEAGLDGAKGEKGFQGEKGDRGPLGLPGTPGPIGVPGPAGPKGERGSKGDPGMTG 570 580 590 600 610 620 600 610 620 630 640 pF1KE2 ------FPG---PRGEKGDLGEKGEKGFRGVKGEKGEPGQPGLDGLDAPCQLGPDGLPMP .:: : :.::. ::.:.:: :: ::.::. : ::: :::: :: ::::. CCDS44 PTGAAGLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL---DAPCPLGEDGLPVQ 630 640 650 660 670 680 650 pF1KE2 GCWQK : CCDS44 GCWNK >>CCDS44428.2 COL13A1 gene_id:1305|Hs109|chr10 (610 aa) initn: 2997 init1: 1034 opt: 1478 Z-score: 655.7 bits: 131.5 E(33420): 3.4e-30 Smith-Waterman score: 1640; 43.8% identity (55.8% similar) in 651 aa overlap (28-654:37-610) 10 20 30 40 50 pF1KE2 MLLKKHAGKGGGREPRSEDPTPAEQHCARTMPP--CAVLAALLSVVAVVSCLYLGVK :: : :..:. : .:. : . CCDS44 HKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLAL--SLLAHFR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 TNDLQARIAALESAKGAPSIHLLPDTLDHLKTMVQEKVERLLAQKSYEHMAKIRIAREAP : .::::. ::. .: ....: . .:..:: .: : . : : .. CCDS44 TAELQARVLRLEAERGE----------QQMETAILGRVNQLLDEKWKLHSRRRREAPKTS 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 SECNCPAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKGDKGEQGDQGPRMVFPKINHGFL :::: :::: : : : : :: : : ::: : :. : :: CCDS44 PGCNCPPGPPGPTG---RPGLPGQPGTRGFPGFPGPIGLDGKPGHPGP------------ 120 130 140 150 180 190 200 210 220 pF1KE2 SADQQLIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPR----GMPG--------- :::.: .:::: ::: : .: :. :. : .::. CCDS44 ------------KGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIA 160 170 180 190 200 230 240 250 260 270 280 pF1KE2 VPGEPGKPGEQGLMGPLGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGPKGEPG . :: .. . :: :: :::: .: .: ::.: : : ::::: :::::.:: CCDS44 LKGEQSQASIQGPPGPPGPPGPSGPLGHPGLP---GPMGPPGLPGP------PGPKGDPG 210 220 230 240 250 290 300 310 320 330 pF1KE2 EQGEKGDAGENG-P--KGDTGEKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLPGLPGI :: .: :: : : : : :: :: ..::.::::: : :.:: : :::::: : CCDS44 IQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGSPGLPGLLGQ 260 270 280 290 300 310 340 350 360 370 380 390 pF1KE2 KGEPGFIGPQGEPGLPGLPGTKGERGEAGPPGRGERGEPGAPGPKGKQGESGTRGPKGSK ::: : : . : ::: :::: :: :::::. : .: :: :. CCDS44 KGEKGDAGNS----------IGGGRGEPGPPGL-----PGPPGPKGEAGVDGQVGPPGQP 320 330 340 350 360 400 410 420 430 440 450 pF1KE2 GDRGEKGDSGAQGPRGPPGQKGDQGATEIIDYNGNLHEALQRITTLTVTGPPG------P ::.::.: .: ::: :: :.::. : :..:::::..::::.: ::.. :::: : CCDS44 GDKGERGAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGP 370 380 390 400 410 420 460 470 480 490 500 510 pF1KE2 PGPQGLQGPKGEQGSPGIPGMDGEQGLKGSKGDMGDPGMTGEKGGIGLPGLPGANGMKGE :: :. : ::: : :: :: :::.: .:. :::: :: : : : ::. : :: : CCDS44 PGAPGIPGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGS 430 440 450 460 470 480 520 530 540 550 560 570 pF1KE2 KGDSGMPGPQGPSIIGPPGPPGPHGPPGPMGPHGLPGPKGTDGPMGPHGPAGPKGERGEK :..: : : . :: :::.::::: : .:.::::: :: : .::: CCDS44 PGEKGEKGETGQAGSPVPGLPGPEGPPGPPGLQGVPGPKGE---------AGLDGAKGEK 490 500 510 520 530 580 590 600 610 620 630 pF1KE2 GAMGEPGPRGPYGLPGKDGEPGLDGFPGPRGEKGDLGEKGEKGFRGVKGEKGEPGQPGLD : .:: : ::: :::: :: : ::: : ::. : ::. :. : : : :: : CCDS44 GFQGEKGDRGPLGLPGT---PGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGLHGPP 540 550 560 570 580 590 640 650 pF1KE2 GLDAPCQLGPDGLPMPGCWQK : : . : ::::. :::.: CCDS44 G-DKGNR-GEDGLPVQGCWNK 600 610 >>CCDS8759.1 COL2A1 gene_id:1280|Hs109|chr12 (1418 aa) initn: 3019 init1: 544 opt: 1473 Z-score: 650.0 bits: 131.7 E(33420): 7.1e-30 Smith-Waterman score: 1535; 44.4% identity (54.9% similar) in 572 aa overlap (121-650:145-684) 100 110 120 130 140 150 pF1KE2 EKVERLLAQKSYEHMAKIRIAREAPSECNCPAGPPGKRGKRGRRGESGPPGQPGPQGPPG ::: :: .: .: :: : :: ::.:: : CCDS87 AGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRG 120 130 140 150 160 170 160 170 180 190 200 pF1KE2 PKGDKGEQGDQGPRMVFPKINHGFLSADQQLIKRRLIKGDQGQAGPPGPPGPPG---PRG : : :. ::.: : .. : : :: : :: :: :: :: CCDS87 PPGPPGKPGDDGEAGKPGKAGE------------RGPPGPQGARGFPGTPGLPGVKGHRG 180 190 200 210 220 210 220 230 240 250 260 pF1KE2 PPGDTGKDGPRGMPGVPGEPGKPGEQGLMGPLGP---PGQKGSIGAPGIPGMNGQKGEPG :: : : : ::: :: :.:::.: ::.:: ::..: : : : :. :.:: CCDS87 YPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPG 230 240 250 260 270 280 270 280 290 300 310 320 pF1KE2 L---PGAVGQNGIPGPKGEPGEQGEKGDAGENGPKGDTGEKGDPGSSAAGIKGEPGESGR :: :: : :: : :: .:: : .: ::.: : .:.::. : : : :: CCDS87 PAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGT--PGSPGPAGASGN 290 300 310 320 330 340 330 340 350 360 370 pF1KE2 PGQKGEPGLPGLPGLPGIKGEPGFIGPQGEPGLPGLPGTKGERGEAGPPG----RGERGE :: : :: : : ::: : ::: ::.: :: : : : .:..: :: .::.: CCDS87 PGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGP 350 360 370 380 390 400 380 390 400 410 420 430 pF1KE2 PGAPGPKGKQGESGTRGPKGSKGDRGEKGDSGAQGPRGPPGQKGDQGATEIIDYNGNLHE : ::: : :: :: : .: :: .:. :. :: ::::..: : . .: CCDS87 KGEPGPAGPQGAP---GPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDG---- 410 420 430 440 450 440 450 460 470 480 490 pF1KE2 ALQRITTLTVTGPPGPPG---PQGLQGPKG---EQGSPGIPGMDGEQGLKGSKGDMGDPG ..:: : :: :.:: :::: . : :: ::. : .:: : :: : : CCDS87 ---------LAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQG 460 470 480 490 500 500 510 520 530 540 pF1KE2 MTGEKGGIGL---PGLPGANGMKGEKGDSGMPGPQGPSIIGPPGPPGPHGPPGPMGPHGL .: .:. : :: :: .: .:. : :.:::.: . : :: : .: :: : .:: CCDS87 KVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGAN--GEPGKAGEKGLPGAPGLRGL 510 520 530 540 550 560 550 560 570 580 590 pF1KE2 PGPKGTDGPMGPHGPAGPKGERGEKGA------MGEPGPRGPYGL---PGKDGEPGLDGF :: : : :: ::::: :::::.:: .: ::: :: : :: .: :: : CCDS87 PGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGA 570 580 590 600 610 620 600 610 620 630 640 pF1KE2 PG---PRGEKGDLGEKGEKGFRGVKGEKGEPGQPGLDG-------LDAPCQLGPDGLP-M :: ::::.: ::.: : .:..: .: :: :: :: : :: :: : CCDS87 PGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGM 630 640 650 660 670 680 650 pF1KE2 PGCWQK :: CCDS87 PGERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGP 690 700 710 720 730 740 >-- initn: 2466 init1: 521 opt: 1246 Z-score: 553.4 bits: 113.8 E(33420): 1.7e-24 Smith-Waterman score: 1378; 44.6% identity (57.4% similar) in 500 aa overlap (126-607:687-1163) 100 110 120 130 140 150 pF1KE2 LLAQKSYEHMAKIRIAREAPSECNCPAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKGDK : : : .:. : :. ::.: :: : . CCDS87 GTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGR 660 670 680 690 700 710 160 170 180 190 200 210 pF1KE2 GEQGDQGPRMVFPKINHGFLSADQQLIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKD : : :: : : .:. :..:..::::: : : :: ::. :. CCDS87 GLTGPIGP----P----GPAGAN----------GEKGEVGPPGPAGSAGARGAPGERGET 720 730 740 750 220 230 240 250 260 270 pF1KE2 GPRGMPGVPGEPGKPGEQGLMGPLGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIP :: : : : :: :. : : : ::::. :::: : .: : : :..: .: CCDS87 GPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGAR 760 770 780 790 800 810 280 290 300 310 320 330 pF1KE2 GPKGEPGEQGEKGDAGENGPKGDTGEKGDPG----SSAAGIKGEPGESGRPGQKGEPGLP : .: :: : : ::. :: :..:. : :: :. : :: :.:: ::. ::::: CCDS87 GAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQ 820 830 840 850 860 870 340 350 360 370 380 390 pF1KE2 GLPGLPGIKGEPGFIGPQGEPGLPGLPGTKGERGEAGPPG-RGERGEPGAPGPKGKQGES : : :: ::::: ::.: : :: : :.:: .: :: ::::: :: :::.:. :.. CCDS87 GPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQ 880 890 900 910 920 930 400 410 420 430 440 pF1KE2 GTRGPKGSKGDRGEKGDSGAQGPRGPPGQKGDQGATEIIDYNGNLHEALQRITTLTV--- :. : .:..: : : : :: : ::..:. :: .: .: : .: CCDS87 GAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAP 940 950 960 970 980 990 450 460 470 480 490 500 pF1KE2 --TGPPGPPGPQGLQGPKGEQGSPGIPGMDGEQGLKGSKGDMGDPGMTGEKGGIGLPGLP :::: ::: : : .:..: : : : .: :..: .: : :.:: : :: CCDS87 GAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGER 1000 1010 1020 1030 1040 1050 510 520 530 540 550 560 pF1KE2 GANGMKGEKGDSGMPGPQGPS----IIGPPGPPGPHGPPGPMGPHGLPGPKGTDGPMGPH : .: .: : .:.::: ::: :: :: ::.:::::.:: : : .: ::.:: CCDS87 GLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPP 1060 1070 1080 1090 1100 1110 570 580 590 600 610 pF1KE2 GPAGPKGERGEKGAMGEPGPRGPYGLPGKDGEPGLD--GFPG--PRGEKGDLGEKGEKGF :: : .:: : : :.::: :: : :: ::.: .: : :: ::: CCDS87 GPRGRSGETGPAGPPGNPGPPGPPGPPG----PGIDMSAFAGLGPR-EKGPDPLQYMRAD 1120 1130 1140 1150 1160 1170 620 630 640 650 pF1KE2 RGVKGEKGEPGQPGLDGLDAPCQLGPDGLPMPGCWQK CCDS87 QAAGGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGDYWIDP 1180 1190 1200 1210 1220 1230 654 residues in 1 query sequences 18921897 residues in 33420 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Aug 1 17:01:44 2019 done: Thu Aug 1 17:01:44 2019 Total Scan time: 2.050 Total Display time: 0.150 Function used was FASTA [36.3.4 Apr, 2011]