FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2761, 835 aa 1>>>pF1KE2761 835 - 835 aa - 835 aa Library: human.CCDS.faa 18921897 residues in 33420 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5432+/-0.00116; mu= 18.7806+/- 0.070 mean_var=61.8144+/-12.432, 0's: 0 Z-trim(101.1): 22 B-trim: 97 in 1/47 Lambda= 0.163128 statistics sampled from 6475 (6483) to 6475 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.544), E-opt: 0.2 (0.194), width: 16 Scan time: 1.800 The best scores are: opt bits E(33420) CCDS47234.1 HMGCR gene_id:3156|Hs109|chr5 ( 835) 5428 1286.9 0 CCDS4027.1 HMGCR gene_id:3156|Hs109|chr5 ( 888) 3420 814.3 0 >>CCDS47234.1 HMGCR gene_id:3156|Hs109|chr5 (835 aa) initn: 5428 init1: 5428 opt: 5428 Z-score: 6895.4 bits: 1286.9 E(33420): 0 Smith-Waterman score: 5428; 100.0% identity (100.0% similar) in 835 aa overlap (1-835:1-835) 10 20 30 40 50 60 pF1KE2 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLLGGGASSRVLADGMTRGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLLGGGASSRVLADGMTRGPV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 VRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 VRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 AMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 AMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 AKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 AKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 SSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 SSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGE 730 740 750 760 770 780 790 800 810 820 830 pF1KE2 NARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 NARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA 790 800 810 820 830 >>CCDS4027.1 HMGCR gene_id:3156|Hs109|chr5 (888 aa) initn: 3393 init1: 3393 opt: 3420 Z-score: 4341.0 bits: 814.3 E(33420): 0 Smith-Waterman score: 5175; 93.9% identity (93.9% similar) in 867 aa overlap (1-814:1-867) 10 20 30 40 50 60 pF1KE2 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK 430 440 450 460 470 480 490 500 510 520 pF1KE2 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSL------------------- ::::::::::::::::::::::::::::::::::::::::: CCDS40 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV 490 500 510 520 530 540 530 540 pF1KE2 ----------------------------------LGGGASSRVLADGMTRGPVVRLPRAC :::::::::::::::::::::::::: CCDS40 AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC 550 560 570 580 590 600 550 560 570 580 590 600 pF1KE2 DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI 610 620 630 640 650 660 610 620 630 640 650 660 pF1KE2 SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV 670 680 690 700 710 720 670 680 690 700 710 720 pF1KE2 LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL 730 740 750 760 770 780 730 740 750 760 770 780 pF1KE2 MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR 790 800 810 820 830 840 790 800 810 820 830 pF1KE2 IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA ::::::::::::::::::::::::::: CCDS40 IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA 850 860 870 880 835 residues in 1 query sequences 18921897 residues in 33420 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Oct 3 17:23:20 2019 done: Thu Oct 3 17:23:20 2019 Total Scan time: 1.800 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]