FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2761, 835 aa 1>>>pF1KE2761 835 - 835 aa - 835 aa Library: /omim/omim.rfq.tfa 64369986 residues in 92320 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3181+/-0.000486; mu= 20.4691+/- 0.030 mean_var=66.5398+/-13.365, 0's: 0 Z-trim(108.0): 33 B-trim: 401 in 1/51 Lambda= 0.157229 statistics sampled from 16723 (16753) to 16723 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.521), E-opt: 0.2 (0.181), width: 16 Scan time: 5.650 The best scores are: opt bits E(92320) NP_001124468 (OMIM: 142910) 3-hydroxy-3-methylglut ( 835) 5428 1241.2 0 XP_011541661 (OMIM: 142910) 3-hydroxy-3-methylglut ( 855) 5428 1241.2 0 NP_001351116 (OMIM: 142910) 3-hydroxy-3-methylglut ( 888) 3420 785.7 0 XP_011541660 (OMIM: 142910) 3-hydroxy-3-methylglut ( 888) 3420 785.7 0 NP_000850 (OMIM: 142910) 3-hydroxy-3-methylglutary ( 888) 3420 785.7 0 XP_011541659 (OMIM: 142910) 3-hydroxy-3-methylglut ( 908) 3420 785.7 0 NP_001306973 (OMIM: 601510) sterol regulatory elem (1023) 220 59.9 7.3e-08 XP_005265025 (OMIM: 601510) sterol regulatory elem (1024) 220 59.9 7.3e-08 XP_005265024 (OMIM: 601510) sterol regulatory elem (1278) 220 60.0 8.8e-08 XP_016861407 (OMIM: 601510) sterol regulatory elem (1279) 220 60.0 8.8e-08 XP_011531803 (OMIM: 601510) sterol regulatory elem (1279) 220 60.0 8.8e-08 NP_036367 (OMIM: 601510) sterol regulatory element (1279) 220 60.0 8.8e-08 XP_016881276 (OMIM: 257220,607623) NPC intracellul (1256) 166 47.7 0.00042 XP_016881275 (OMIM: 257220,607623) NPC intracellul (1264) 166 47.7 0.00043 XP_016881274 (OMIM: 257220,607623) NPC intracellul (1273) 166 47.7 0.00043 XP_006722542 (OMIM: 257220,607623) NPC intracellul (1273) 166 47.7 0.00043 NP_000262 (OMIM: 257220,607623) NPC intracellular (1278) 166 47.7 0.00043 XP_016881273 (OMIM: 257220,607623) NPC intracellul (1281) 166 47.7 0.00043 XP_005258336 (OMIM: 257220,607623) NPC intracellul (1286) 166 47.7 0.00043 XP_005258335 (OMIM: 257220,607623) NPC intracellul (1295) 166 47.7 0.00043 XP_005258334 (OMIM: 257220,607623) NPC intracellul (1303) 166 47.7 0.00044 XP_011512941 (OMIM: 616908) patched domain-contain ( 593) 155 45.0 0.0013 XP_016866382 (OMIM: 616908) patched domain-contain ( 843) 155 45.1 0.0017 NP_001013754 (OMIM: 616908) patched domain-contain ( 846) 155 45.1 0.0017 XP_016866381 (OMIM: 616908) patched domain-contain ( 901) 155 45.1 0.0018 XP_016866380 (OMIM: 616908) patched domain-contain ( 904) 155 45.1 0.0018 >>NP_001124468 (OMIM: 142910) 3-hydroxy-3-methylglutaryl (835 aa) initn: 5428 init1: 5428 opt: 5428 Z-score: 6648.6 bits: 1241.2 E(92320): 0 Smith-Waterman score: 5428; 100.0% identity (100.0% similar) in 835 aa overlap (1-835:1-835) 10 20 30 40 50 60 pF1KE2 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLLGGGASSRVLADGMTRGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLLGGGASSRVLADGMTRGPV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 VRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 AMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 AKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 SSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGE 730 740 750 760 770 780 790 800 810 820 830 pF1KE2 NARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA 790 800 810 820 830 >>XP_011541661 (OMIM: 142910) 3-hydroxy-3-methylglutaryl (855 aa) initn: 5428 init1: 5428 opt: 5428 Z-score: 6648.4 bits: 1241.2 E(92320): 0 Smith-Waterman score: 5428; 100.0% identity (100.0% similar) in 835 aa overlap (1-835:21-855) 10 20 30 40 pF1KE2 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGN :::::::::::::::::::::::::::::::::::::::: XP_011 MQWMSHTRERDAGSKDSVATMLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGN 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 NKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTI 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE2 FSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE2 MAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE2 ELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQ 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE2 NSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFE 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE2 QTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVI 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE2 KPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAK 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE2 FLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYS 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE2 LLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQK 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE2 LHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKP 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE2 AAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHA 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE2 ANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLP 730 740 750 760 770 780 770 780 790 800 810 820 pF1KE2 QQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSK 790 800 810 820 830 840 830 pF1KE2 INLQDLQGACTKKTA ::::::::::::::: XP_011 INLQDLQGACTKKTA 850 >>NP_001351116 (OMIM: 142910) 3-hydroxy-3-methylglutaryl (888 aa) initn: 3393 init1: 3393 opt: 3420 Z-score: 4186.6 bits: 785.7 E(92320): 0 Smith-Waterman score: 5175; 93.9% identity (93.9% similar) in 867 aa overlap (1-814:1-867) 10 20 30 40 50 60 pF1KE2 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK 430 440 450 460 470 480 490 500 510 520 pF1KE2 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSL------------------- ::::::::::::::::::::::::::::::::::::::::: NP_001 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV 490 500 510 520 530 540 530 540 pF1KE2 ----------------------------------LGGGASSRVLADGMTRGPVVRLPRAC :::::::::::::::::::::::::: NP_001 AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC 550 560 570 580 590 600 550 560 570 580 590 600 pF1KE2 DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI 610 620 630 640 650 660 610 620 630 640 650 660 pF1KE2 SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV 670 680 690 700 710 720 670 680 690 700 710 720 pF1KE2 LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL 730 740 750 760 770 780 730 740 750 760 770 780 pF1KE2 MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR 790 800 810 820 830 840 790 800 810 820 830 pF1KE2 IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA ::::::::::::::::::::::::::: NP_001 IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA 850 860 870 880 >>XP_011541660 (OMIM: 142910) 3-hydroxy-3-methylglutaryl (888 aa) initn: 3393 init1: 3393 opt: 3420 Z-score: 4186.6 bits: 785.7 E(92320): 0 Smith-Waterman score: 5175; 93.9% identity (93.9% similar) in 867 aa overlap (1-814:1-867) 10 20 30 40 50 60 pF1KE2 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK 430 440 450 460 470 480 490 500 510 520 pF1KE2 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSL------------------- ::::::::::::::::::::::::::::::::::::::::: XP_011 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV 490 500 510 520 530 540 530 540 pF1KE2 ----------------------------------LGGGASSRVLADGMTRGPVVRLPRAC :::::::::::::::::::::::::: XP_011 AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC 550 560 570 580 590 600 550 560 570 580 590 600 pF1KE2 DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI 610 620 630 640 650 660 610 620 630 640 650 660 pF1KE2 SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV 670 680 690 700 710 720 670 680 690 700 710 720 pF1KE2 LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL 730 740 750 760 770 780 730 740 750 760 770 780 pF1KE2 MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR 790 800 810 820 830 840 790 800 810 820 830 pF1KE2 IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA ::::::::::::::::::::::::::: XP_011 IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA 850 860 870 880 >>NP_000850 (OMIM: 142910) 3-hydroxy-3-methylglutaryl-Co (888 aa) initn: 3393 init1: 3393 opt: 3420 Z-score: 4186.6 bits: 785.7 E(92320): 0 Smith-Waterman score: 5175; 93.9% identity (93.9% similar) in 867 aa overlap (1-814:1-867) 10 20 30 40 50 60 pF1KE2 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK 430 440 450 460 470 480 490 500 510 520 pF1KE2 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSL------------------- ::::::::::::::::::::::::::::::::::::::::: NP_000 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV 490 500 510 520 530 540 530 540 pF1KE2 ----------------------------------LGGGASSRVLADGMTRGPVVRLPRAC :::::::::::::::::::::::::: NP_000 AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC 550 560 570 580 590 600 550 560 570 580 590 600 pF1KE2 DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI 610 620 630 640 650 660 610 620 630 640 650 660 pF1KE2 SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV 670 680 690 700 710 720 670 680 690 700 710 720 pF1KE2 LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL 730 740 750 760 770 780 730 740 750 760 770 780 pF1KE2 MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR 790 800 810 820 830 840 790 800 810 820 830 pF1KE2 IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA ::::::::::::::::::::::::::: NP_000 IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA 850 860 870 880 >>XP_011541659 (OMIM: 142910) 3-hydroxy-3-methylglutaryl (908 aa) initn: 3393 init1: 3393 opt: 3420 Z-score: 4186.4 bits: 785.7 E(92320): 0 Smith-Waterman score: 5175; 93.9% identity (93.9% similar) in 867 aa overlap (1-814:21-887) 10 20 30 40 pF1KE2 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGN :::::::::::::::::::::::::::::::::::::::: XP_011 MQWMSHTRERDAGSKDSVATMLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGN 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 NKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTI 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE2 FSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE2 MAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE2 ELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQ 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE2 NSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFE 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE2 QTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVI 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE2 KPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAK 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE2 FLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYS 490 500 510 520 530 540 pF1KE2 L-----------------------------------------------------LGGGAS : :::::: XP_011 LVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGAS 550 560 570 580 590 600 530 540 550 560 570 580 pF1KE2 SRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAG 610 620 630 640 650 660 590 600 610 620 630 640 pF1KE2 RNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIE 670 680 690 700 710 720 650 660 670 680 690 700 pF1KE2 GRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAI 730 740 750 760 770 780 710 720 730 740 750 760 pF1KE2 YIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQM 790 800 810 820 830 840 770 780 790 800 810 820 pF1KE2 LGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQ ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQ 850 860 870 880 890 900 830 pF1KE2 GACTKKTA XP_011 GACTKKTA >>NP_001306973 (OMIM: 601510) sterol regulatory element- (1023 aa) initn: 108 init1: 75 opt: 220 Z-score: 262.7 bits: 59.9 E(92320): 7.3e-08 Smith-Waterman score: 232; 24.2% identity (63.7% similar) in 215 aa overlap (53-253:21-234) 30 40 50 60 70 80 pF1KE2 GTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQN :.:.. ...: :. : : . ::::. .. NP_001 MLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRK 10 20 30 40 50 90 100 110 120 130 140 pF1KE2 LRQLGSKYILGIAGLFTIFSSFVFST--VVIHFLDKELTGLNEALPFFLLLIDLSRASTL . .. ::. :..:.. :..::...:. .. : :.: .: .:.....: : . .: NP_001 IDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNG-GEIFPYLVVVIGLENVLVL 60 70 80 90 100 150 160 170 180 190 200 pF1KE2 AKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMS .: ..:. . ::. ::.:.. . .. . .: .: .: .. : .. .: :. .. NP_001 TKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVG 110 120 130 140 150 160 210 220 230 240 pF1KE2 VLANYFVFMTFFPACVSL---VLELSRESRE---------GRPIWQLSHFARVLEEEENK .....:. : :: . .:. .::. ... ..:. : ... : : . . NP_001 LVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAVRPST 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE2 PNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLW :. .: NP_001 PHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRNYLA 230 240 250 260 270 280 >>XP_005265025 (OMIM: 601510) sterol regulatory element- (1024 aa) initn: 108 init1: 75 opt: 220 Z-score: 262.7 bits: 59.9 E(92320): 7.3e-08 Smith-Waterman score: 232; 24.2% identity (63.7% similar) in 215 aa overlap (53-253:21-234) 30 40 50 60 70 80 pF1KE2 GTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQN :.:.. ...: :. : : . ::::. .. XP_005 MLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRK 10 20 30 40 50 90 100 110 120 130 140 pF1KE2 LRQLGSKYILGIAGLFTIFSSFVFST--VVIHFLDKELTGLNEALPFFLLLIDLSRASTL . .. ::. :..:.. :..::...:. .. : :.: .: .:.....: : . .: XP_005 IDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNG-GEIFPYLVVVIGLENVLVL 60 70 80 90 100 150 160 170 180 190 200 pF1KE2 AKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMS .: ..:. . ::. ::.:.. . .. . .: .: .: .. : .. .: :. .. XP_005 TKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVG 110 120 130 140 150 160 210 220 230 240 pF1KE2 VLANYFVFMTFFPACVSL---VLELSRESRE---------GRPIWQLSHFARVLEEEENK .....:. : :: . .:. .::. ... ..:. : ... : : . . XP_005 LVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAVRPST 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE2 PNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLW :. .: XP_005 PHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRNYLA 230 240 250 260 270 280 >>XP_005265024 (OMIM: 601510) sterol regulatory element- (1278 aa) initn: 161 init1: 75 opt: 220 Z-score: 261.3 bits: 60.0 E(92320): 8.8e-08 Smith-Waterman score: 232; 24.2% identity (63.7% similar) in 215 aa overlap (53-253:276-489) 30 40 50 60 70 80 pF1KE2 GTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQN :.:.. ...: :. : : . ::::. .. XP_005 KFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRK 250 260 270 280 290 300 90 100 110 120 130 140 pF1KE2 LRQLGSKYILGIAGLFTIFSSFVFST--VVIHFLDKELTGLNEALPFFLLLIDLSRASTL . .. ::. :..:.. :..::...:. .. : :.: .: .:.....: : . .: XP_005 IDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNG-GEIFPYLVVVIGLENVLVL 310 320 330 340 350 360 150 160 170 180 190 200 pF1KE2 AKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMS .: ..:. . ::. ::.:.. . .. . .: .: .: .. : .. .: :. .. XP_005 TKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVG 370 380 390 400 410 420 210 220 230 240 pF1KE2 VLANYFVFMTFFPACVSL---VLELSRESRE---------GRPIWQLSHFARVLEEEENK .....:. : :: . .:. .::. ... ..:. : ... : : . . XP_005 LVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAVRPST 430 440 450 460 470 480 250 260 270 280 290 300 pF1KE2 PNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLW :. .: XP_005 PHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRNYLA 490 500 510 520 530 540 >>XP_016861407 (OMIM: 601510) sterol regulatory element- (1279 aa) initn: 161 init1: 75 opt: 220 Z-score: 261.3 bits: 60.0 E(92320): 8.8e-08 Smith-Waterman score: 232; 24.2% identity (63.7% similar) in 215 aa overlap (53-253:276-489) 30 40 50 60 70 80 pF1KE2 GTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQN :.:.. ...: :. : : . ::::. .. XP_016 KFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRK 250 260 270 280 290 300 90 100 110 120 130 140 pF1KE2 LRQLGSKYILGIAGLFTIFSSFVFST--VVIHFLDKELTGLNEALPFFLLLIDLSRASTL . .. ::. :..:.. :..::...:. .. : :.: .: .:.....: : . .: XP_016 IDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNG-GEIFPYLVVVIGLENVLVL 310 320 330 340 350 360 150 160 170 180 190 200 pF1KE2 AKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMS .: ..:. . ::. ::.:.. . .. . .: .: .: .. : .. .: :. .. XP_016 TKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVG 370 380 390 400 410 420 210 220 230 240 pF1KE2 VLANYFVFMTFFPACVSL---VLELSRESRE---------GRPIWQLSHFARVLEEEENK .....:. : :: . .:. .::. ... ..:. : ... : : . . XP_016 LVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAVRPST 430 440 450 460 470 480 250 260 270 280 290 300 pF1KE2 PNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLW :. .: XP_016 PHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRNYLA 490 500 510 520 530 540 835 residues in 1 query sequences 64369986 residues in 92320 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Oct 3 17:23:20 2019 done: Thu Oct 3 17:23:21 2019 Total Scan time: 5.650 Total Display time: 0.160 Function used was FASTA [36.3.4 Apr, 2011]