Result of FASTA (omim) for
pF1KE2761
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2761, 835 aa
1>>>pF1KE2761 835 - 835 aa - 835 aa
Library: /omim/omim.rfq.tfa
64369986 residues in 92320 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3181+/-0.000486; mu= 20.4691+/- 0.030
mean_var=66.5398+/-13.365, 0's: 0 Z-trim(108.0): 33 B-trim: 401 in 1/51
Lambda= 0.157229
statistics sampled from 16723 (16753) to 16723 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.521), E-opt: 0.2 (0.181), width: 16
Scan time: 5.650
The best scores are: opt bits E(92320)
NP_001124468 (OMIM: 142910) 3-hydroxy-3-methylglut ( 835) 5428 1241.2 0
XP_011541661 (OMIM: 142910) 3-hydroxy-3-methylglut ( 855) 5428 1241.2 0
NP_001351116 (OMIM: 142910) 3-hydroxy-3-methylglut ( 888) 3420 785.7 0
XP_011541660 (OMIM: 142910) 3-hydroxy-3-methylglut ( 888) 3420 785.7 0
NP_000850 (OMIM: 142910) 3-hydroxy-3-methylglutary ( 888) 3420 785.7 0
XP_011541659 (OMIM: 142910) 3-hydroxy-3-methylglut ( 908) 3420 785.7 0
NP_001306973 (OMIM: 601510) sterol regulatory elem (1023) 220 59.9 7.3e-08
XP_005265025 (OMIM: 601510) sterol regulatory elem (1024) 220 59.9 7.3e-08
XP_005265024 (OMIM: 601510) sterol regulatory elem (1278) 220 60.0 8.8e-08
XP_016861407 (OMIM: 601510) sterol regulatory elem (1279) 220 60.0 8.8e-08
XP_011531803 (OMIM: 601510) sterol regulatory elem (1279) 220 60.0 8.8e-08
NP_036367 (OMIM: 601510) sterol regulatory element (1279) 220 60.0 8.8e-08
XP_016881276 (OMIM: 257220,607623) NPC intracellul (1256) 166 47.7 0.00042
XP_016881275 (OMIM: 257220,607623) NPC intracellul (1264) 166 47.7 0.00043
XP_016881274 (OMIM: 257220,607623) NPC intracellul (1273) 166 47.7 0.00043
XP_006722542 (OMIM: 257220,607623) NPC intracellul (1273) 166 47.7 0.00043
NP_000262 (OMIM: 257220,607623) NPC intracellular (1278) 166 47.7 0.00043
XP_016881273 (OMIM: 257220,607623) NPC intracellul (1281) 166 47.7 0.00043
XP_005258336 (OMIM: 257220,607623) NPC intracellul (1286) 166 47.7 0.00043
XP_005258335 (OMIM: 257220,607623) NPC intracellul (1295) 166 47.7 0.00043
XP_005258334 (OMIM: 257220,607623) NPC intracellul (1303) 166 47.7 0.00044
XP_011512941 (OMIM: 616908) patched domain-contain ( 593) 155 45.0 0.0013
XP_016866382 (OMIM: 616908) patched domain-contain ( 843) 155 45.1 0.0017
NP_001013754 (OMIM: 616908) patched domain-contain ( 846) 155 45.1 0.0017
XP_016866381 (OMIM: 616908) patched domain-contain ( 901) 155 45.1 0.0018
XP_016866380 (OMIM: 616908) patched domain-contain ( 904) 155 45.1 0.0018
>>NP_001124468 (OMIM: 142910) 3-hydroxy-3-methylglutaryl (835 aa)
initn: 5428 init1: 5428 opt: 5428 Z-score: 6648.6 bits: 1241.2 E(92320): 0
Smith-Waterman score: 5428; 100.0% identity (100.0% similar) in 835 aa overlap (1-835:1-835)
10 20 30 40 50 60
pF1KE2 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLLGGGASSRVLADGMTRGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLLGGGASSRVLADGMTRGPV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 VRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 AMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 AKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGE
730 740 750 760 770 780
790 800 810 820 830
pF1KE2 NARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
790 800 810 820 830
>>XP_011541661 (OMIM: 142910) 3-hydroxy-3-methylglutaryl (855 aa)
initn: 5428 init1: 5428 opt: 5428 Z-score: 6648.4 bits: 1241.2 E(92320): 0
Smith-Waterman score: 5428; 100.0% identity (100.0% similar) in 835 aa overlap (1-835:21-855)
10 20 30 40
pF1KE2 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGN
::::::::::::::::::::::::::::::::::::::::
XP_011 MQWMSHTRERDAGSKDSVATMLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGN
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE2 NKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTI
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE2 FSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARG
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE2 MAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVL
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE2 ELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQ
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE2 NSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFE
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE2 QTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVI
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE2 KPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAK
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE2 FLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYS
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE2 LLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQK
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE2 LHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKP
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE2 AAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHA
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE2 ANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLP
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE2 QQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSK
790 800 810 820 830 840
830
pF1KE2 INLQDLQGACTKKTA
:::::::::::::::
XP_011 INLQDLQGACTKKTA
850
>>NP_001351116 (OMIM: 142910) 3-hydroxy-3-methylglutaryl (888 aa)
initn: 3393 init1: 3393 opt: 3420 Z-score: 4186.6 bits: 785.7 E(92320): 0
Smith-Waterman score: 5175; 93.9% identity (93.9% similar) in 867 aa overlap (1-814:1-867)
10 20 30 40 50 60
pF1KE2 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
430 440 450 460 470 480
490 500 510 520
pF1KE2 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSL-------------------
:::::::::::::::::::::::::::::::::::::::::
NP_001 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
490 500 510 520 530 540
530 540
pF1KE2 ----------------------------------LGGGASSRVLADGMTRGPVVRLPRAC
::::::::::::::::::::::::::
NP_001 AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC
550 560 570 580 590 600
550 560 570 580 590 600
pF1KE2 DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
610 620 630 640 650 660
610 620 630 640 650 660
pF1KE2 SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
670 680 690 700 710 720
670 680 690 700 710 720
pF1KE2 LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
730 740 750 760 770 780
730 740 750 760 770 780
pF1KE2 MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
790 800 810 820 830 840
790 800 810 820 830
pF1KE2 IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
:::::::::::::::::::::::::::
NP_001 IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
850 860 870 880
>>XP_011541660 (OMIM: 142910) 3-hydroxy-3-methylglutaryl (888 aa)
initn: 3393 init1: 3393 opt: 3420 Z-score: 4186.6 bits: 785.7 E(92320): 0
Smith-Waterman score: 5175; 93.9% identity (93.9% similar) in 867 aa overlap (1-814:1-867)
10 20 30 40 50 60
pF1KE2 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
430 440 450 460 470 480
490 500 510 520
pF1KE2 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSL-------------------
:::::::::::::::::::::::::::::::::::::::::
XP_011 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
490 500 510 520 530 540
530 540
pF1KE2 ----------------------------------LGGGASSRVLADGMTRGPVVRLPRAC
::::::::::::::::::::::::::
XP_011 AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC
550 560 570 580 590 600
550 560 570 580 590 600
pF1KE2 DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
610 620 630 640 650 660
610 620 630 640 650 660
pF1KE2 SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
670 680 690 700 710 720
670 680 690 700 710 720
pF1KE2 LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
730 740 750 760 770 780
730 740 750 760 770 780
pF1KE2 MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
790 800 810 820 830 840
790 800 810 820 830
pF1KE2 IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
:::::::::::::::::::::::::::
XP_011 IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
850 860 870 880
>>NP_000850 (OMIM: 142910) 3-hydroxy-3-methylglutaryl-Co (888 aa)
initn: 3393 init1: 3393 opt: 3420 Z-score: 4186.6 bits: 785.7 E(92320): 0
Smith-Waterman score: 5175; 93.9% identity (93.9% similar) in 867 aa overlap (1-814:1-867)
10 20 30 40 50 60
pF1KE2 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
430 440 450 460 470 480
490 500 510 520
pF1KE2 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSL-------------------
:::::::::::::::::::::::::::::::::::::::::
NP_000 LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
490 500 510 520 530 540
530 540
pF1KE2 ----------------------------------LGGGASSRVLADGMTRGPVVRLPRAC
::::::::::::::::::::::::::
NP_000 AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC
550 560 570 580 590 600
550 560 570 580 590 600
pF1KE2 DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
610 620 630 640 650 660
610 620 630 640 650 660
pF1KE2 SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
670 680 690 700 710 720
670 680 690 700 710 720
pF1KE2 LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
730 740 750 760 770 780
730 740 750 760 770 780
pF1KE2 MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
790 800 810 820 830 840
790 800 810 820 830
pF1KE2 IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
:::::::::::::::::::::::::::
NP_000 IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
850 860 870 880
>>XP_011541659 (OMIM: 142910) 3-hydroxy-3-methylglutaryl (908 aa)
initn: 3393 init1: 3393 opt: 3420 Z-score: 4186.4 bits: 785.7 E(92320): 0
Smith-Waterman score: 5175; 93.9% identity (93.9% similar) in 867 aa overlap (1-814:21-887)
10 20 30 40
pF1KE2 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGN
::::::::::::::::::::::::::::::::::::::::
XP_011 MQWMSHTRERDAGSKDSVATMLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGN
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE2 NKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTI
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE2 FSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARG
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE2 MAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVL
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE2 ELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQ
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE2 NSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFE
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE2 QTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVI
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE2 KPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAK
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE2 FLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYS
490 500 510 520 530 540
pF1KE2 L-----------------------------------------------------LGGGAS
: ::::::
XP_011 LVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGAS
550 560 570 580 590 600
530 540 550 560 570 580
pF1KE2 SRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAG
610 620 630 640 650 660
590 600 610 620 630 640
pF1KE2 RNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIE
670 680 690 700 710 720
650 660 670 680 690 700
pF1KE2 GRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAI
730 740 750 760 770 780
710 720 730 740 750 760
pF1KE2 YIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQM
790 800 810 820 830 840
770 780 790 800 810 820
pF1KE2 LGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQ
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQ
850 860 870 880 890 900
830
pF1KE2 GACTKKTA
XP_011 GACTKKTA
>>NP_001306973 (OMIM: 601510) sterol regulatory element- (1023 aa)
initn: 108 init1: 75 opt: 220 Z-score: 262.7 bits: 59.9 E(92320): 7.3e-08
Smith-Waterman score: 232; 24.2% identity (63.7% similar) in 215 aa overlap (53-253:21-234)
30 40 50 60 70 80
pF1KE2 GTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQN
:.:.. ...: :. : : . ::::. ..
NP_001 MLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRK
10 20 30 40 50
90 100 110 120 130 140
pF1KE2 LRQLGSKYILGIAGLFTIFSSFVFST--VVIHFLDKELTGLNEALPFFLLLIDLSRASTL
. .. ::. :..:.. :..::...:. .. : :.: .: .:.....: : . .:
NP_001 IDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNG-GEIFPYLVVVIGLENVLVL
60 70 80 90 100
150 160 170 180 190 200
pF1KE2 AKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMS
.: ..:. . ::. ::.:.. . .. . .: .: .: .. : .. .: :. ..
NP_001 TKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVG
110 120 130 140 150 160
210 220 230 240
pF1KE2 VLANYFVFMTFFPACVSL---VLELSRESRE---------GRPIWQLSHFARVLEEEENK
.....:. : :: . .:. .::. ... ..:. : ... : : . .
NP_001 LVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAVRPST
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE2 PNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLW
:. .:
NP_001 PHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRNYLA
230 240 250 260 270 280
>>XP_005265025 (OMIM: 601510) sterol regulatory element- (1024 aa)
initn: 108 init1: 75 opt: 220 Z-score: 262.7 bits: 59.9 E(92320): 7.3e-08
Smith-Waterman score: 232; 24.2% identity (63.7% similar) in 215 aa overlap (53-253:21-234)
30 40 50 60 70 80
pF1KE2 GTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQN
:.:.. ...: :. : : . ::::. ..
XP_005 MLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRK
10 20 30 40 50
90 100 110 120 130 140
pF1KE2 LRQLGSKYILGIAGLFTIFSSFVFST--VVIHFLDKELTGLNEALPFFLLLIDLSRASTL
. .. ::. :..:.. :..::...:. .. : :.: .: .:.....: : . .:
XP_005 IDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNG-GEIFPYLVVVIGLENVLVL
60 70 80 90 100
150 160 170 180 190 200
pF1KE2 AKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMS
.: ..:. . ::. ::.:.. . .. . .: .: .: .. : .. .: :. ..
XP_005 TKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVG
110 120 130 140 150 160
210 220 230 240
pF1KE2 VLANYFVFMTFFPACVSL---VLELSRESRE---------GRPIWQLSHFARVLEEEENK
.....:. : :: . .:. .::. ... ..:. : ... : : . .
XP_005 LVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAVRPST
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE2 PNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLW
:. .:
XP_005 PHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRNYLA
230 240 250 260 270 280
>>XP_005265024 (OMIM: 601510) sterol regulatory element- (1278 aa)
initn: 161 init1: 75 opt: 220 Z-score: 261.3 bits: 60.0 E(92320): 8.8e-08
Smith-Waterman score: 232; 24.2% identity (63.7% similar) in 215 aa overlap (53-253:276-489)
30 40 50 60 70 80
pF1KE2 GTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQN
:.:.. ...: :. : : . ::::. ..
XP_005 KFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRK
250 260 270 280 290 300
90 100 110 120 130 140
pF1KE2 LRQLGSKYILGIAGLFTIFSSFVFST--VVIHFLDKELTGLNEALPFFLLLIDLSRASTL
. .. ::. :..:.. :..::...:. .. : :.: .: .:.....: : . .:
XP_005 IDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNG-GEIFPYLVVVIGLENVLVL
310 320 330 340 350 360
150 160 170 180 190 200
pF1KE2 AKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMS
.: ..:. . ::. ::.:.. . .. . .: .: .: .. : .. .: :. ..
XP_005 TKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVG
370 380 390 400 410 420
210 220 230 240
pF1KE2 VLANYFVFMTFFPACVSL---VLELSRESRE---------GRPIWQLSHFARVLEEEENK
.....:. : :: . .:. .::. ... ..:. : ... : : . .
XP_005 LVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAVRPST
430 440 450 460 470 480
250 260 270 280 290 300
pF1KE2 PNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLW
:. .:
XP_005 PHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRNYLA
490 500 510 520 530 540
>>XP_016861407 (OMIM: 601510) sterol regulatory element- (1279 aa)
initn: 161 init1: 75 opt: 220 Z-score: 261.3 bits: 60.0 E(92320): 8.8e-08
Smith-Waterman score: 232; 24.2% identity (63.7% similar) in 215 aa overlap (53-253:276-489)
30 40 50 60 70 80
pF1KE2 GTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQN
:.:.. ...: :. : : . ::::. ..
XP_016 KFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRK
250 260 270 280 290 300
90 100 110 120 130 140
pF1KE2 LRQLGSKYILGIAGLFTIFSSFVFST--VVIHFLDKELTGLNEALPFFLLLIDLSRASTL
. .. ::. :..:.. :..::...:. .. : :.: .: .:.....: : . .:
XP_016 IDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNG-GEIFPYLVVVIGLENVLVL
310 320 330 340 350 360
150 160 170 180 190 200
pF1KE2 AKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMS
.: ..:. . ::. ::.:.. . .. . .: .: .: .. : .. .: :. ..
XP_016 TKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVG
370 380 390 400 410 420
210 220 230 240
pF1KE2 VLANYFVFMTFFPACVSL---VLELSRESRE---------GRPIWQLSHFARVLEEEENK
.....:. : :: . .:. .::. ... ..:. : ... : : . .
XP_016 LVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAVRPST
430 440 450 460 470 480
250 260 270 280 290 300
pF1KE2 PNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLW
:. .:
XP_016 PHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRNYLA
490 500 510 520 530 540
835 residues in 1 query sequences
64369986 residues in 92320 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Oct 3 17:23:20 2019 done: Thu Oct 3 17:23:21 2019
Total Scan time: 5.650 Total Display time: 0.160
Function used was FASTA [36.3.4 Apr, 2011]