FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3139, 350 aa 1>>>pF1KE3139 350 - 350 aa - 350 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1777+/-0.000468; mu= 17.5088+/- 0.029 mean_var=68.8182+/-13.666, 0's: 0 Z-trim(109.6): 90 B-trim: 429 in 1/49 Lambda= 0.154605 statistics sampled from 17742 (17834) to 17742 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.573), E-opt: 0.2 (0.209), width: 16 Scan time: 7.360 The best scores are: opt bits E(85289) NP_000163 (OMIM: 139330,610444,616389) guanine nuc ( 350) 2296 521.4 1.1e-147 NP_653082 (OMIM: 139330,610444,616389) guanine nuc ( 350) 2296 521.4 1.1e-147 XP_011539566 (OMIM: 139340,613856) PREDICTED: guan ( 354) 1937 441.4 1.4e-123 NP_005263 (OMIM: 139340,613856) guanine nucleotide ( 354) 1937 441.4 1.4e-123 NP_001095856 (OMIM: 139395) guanine nucleotide-bin ( 354) 1860 424.2 2.1e-118 NP_002060 (OMIM: 139310) guanine nucleotide-bindin ( 354) 1653 378.0 1.7e-104 NP_006487 (OMIM: 139370,602483) guanine nucleotide ( 354) 1607 367.8 2.1e-101 NP_002061 (OMIM: 139360,192605) guanine nucleotide ( 355) 1605 367.3 2.8e-101 NP_001159897 (OMIM: 139360,192605) guanine nucleot ( 318) 1497 343.2 4.6e-94 NP_001269549 (OMIM: 139360,192605) guanine nucleot ( 339) 1497 343.2 4.9e-94 NP_001269548 (OMIM: 139360,192605) guanine nucleot ( 339) 1497 343.2 4.9e-94 XP_011514426 (OMIM: 139395) PREDICTED: guanine nuc ( 297) 1484 340.3 3.3e-93 NP_001243343 (OMIM: 139310) guanine nucleotide-bin ( 302) 1471 337.4 2.5e-92 NP_066268 (OMIM: 139311,615473) guanine nucleotide ( 354) 1445 331.6 1.6e-90 NP_001269546 (OMIM: 139360,192605) guanine nucleot ( 303) 1418 325.6 9e-89 NP_620073 (OMIM: 139311,615473) guanine nucleotide ( 354) 1413 324.5 2.2e-88 NP_002064 (OMIM: 139160) guanine nucleotide-bindin ( 355) 1293 297.7 2.5e-80 NP_001269547 (OMIM: 139360,192605) guanine nucleot ( 274) 1281 295.0 1.3e-79 XP_011521305 (OMIM: 139311,615473) PREDICTED: guan ( 312) 1261 290.6 3.2e-78 NP_004288 (OMIM: 604397) guanine nucleotide-bindin ( 355) 1094 253.3 5.8e-67 NP_002063 (OMIM: 163000,185300,600998) guanine nuc ( 359) 1093 253.1 6.8e-67 NP_002058 (OMIM: 139313) guanine nucleotide-bindin ( 359) 1086 251.6 2e-66 XP_016870117 (OMIM: 163000,185300,600998) PREDICTE ( 301) 957 222.7 8e-58 XP_016870830 (OMIM: 604397) PREDICTED: guanine nuc ( 301) 946 220.3 4.4e-57 NP_031379 (OMIM: 604394) guanine nucleotide-bindin ( 381) 880 205.6 1.4e-52 NP_002059 (OMIM: 139314) guanine nucleotide-bindin ( 374) 871 203.6 5.7e-52 NP_006563 (OMIM: 604406) guanine nucleotide-bindin ( 377) 868 202.9 9.1e-52 XP_011517526 (OMIM: 604397) PREDICTED: guanine nuc ( 237) 833 195.0 1.4e-49 XP_016884275 (OMIM: 139160) PREDICTED: guanine nuc ( 307) 813 190.6 3.8e-48 NP_001248372 (OMIM: 139312,615073) guanine nucleot ( 381) 809 189.8 8.4e-48 NP_001135811 (OMIM: 139312,615073) guanine nucleot ( 381) 809 189.8 8.4e-48 NP_892023 (OMIM: 139312,615073) guanine nucleotide ( 458) 802 188.3 2.9e-47 NP_001070957 (OMIM: 102200,103580,139320,166350,17 ( 379) 800 187.8 3.4e-47 XP_016883303 (OMIM: 102200,103580,139320,166350,17 (1022) 795 187.0 1.6e-46 NP_536351 (OMIM: 102200,103580,139320,166350,17480 ( 380) 788 185.1 2.1e-46 XP_016883302 (OMIM: 102200,103580,139320,166350,17 (1023) 783 184.3 1e-45 XP_016883304 (OMIM: 102200,103580,139320,166350,17 ( 347) 744 175.3 1.8e-43 XP_016867497 (OMIM: 604394) PREDICTED: guanine nuc ( 253) 708 167.1 3.6e-41 XP_011513590 (OMIM: 604394) PREDICTED: guanine nuc ( 284) 708 167.2 4e-41 NP_001269370 (OMIM: 604394) guanine nucleotide-bin ( 322) 708 167.2 4.4e-41 NP_001269354 (OMIM: 604406) guanine nucleotide-bin ( 282) 677 160.3 4.8e-39 XP_016883306 (OMIM: 102200,103580,139320,166350,17 ( 320) 658 156.1 1e-37 XP_016883308 (OMIM: 102200,103580,139320,166350,17 ( 320) 658 156.1 1e-37 XP_016883307 (OMIM: 102200,103580,139320,166350,17 ( 320) 658 156.1 1e-37 XP_016883305 (OMIM: 102200,103580,139320,166350,17 ( 320) 626 148.9 1.4e-35 XP_016883309 (OMIM: 102200,103580,139320,166350,17 ( 320) 626 148.9 1.4e-35 NP_001296769 (OMIM: 102200,103580,139320,166350,17 ( 335) 626 148.9 1.5e-35 NP_001296790 (OMIM: 102200,103580,139320,166350,17 ( 335) 626 148.9 1.5e-35 NP_000507 (OMIM: 102200,103580,139320,166350,17480 ( 394) 626 149.0 1.7e-35 NP_001070956 (OMIM: 102200,103580,139320,166350,17 ( 395) 626 149.0 1.7e-35 >>NP_000163 (OMIM: 139330,610444,616389) guanine nucleot (350 aa) initn: 2296 init1: 2296 opt: 2296 Z-score: 2772.2 bits: 521.4 E(85289): 1.1e-147 Smith-Waterman score: 2296; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KE3 MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 ECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 DIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 IETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAGNYIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAGNYIK 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 VQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF :::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF 310 320 330 340 350 >>NP_653082 (OMIM: 139330,610444,616389) guanine nucleot (350 aa) initn: 2296 init1: 2296 opt: 2296 Z-score: 2772.2 bits: 521.4 E(85289): 1.1e-147 Smith-Waterman score: 2296; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KE3 MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 ECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 ECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 DIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 DIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 IETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 IETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAGNYIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 ESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAGNYIK 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 VQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF :::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 VQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF 310 320 330 340 350 >>XP_011539566 (OMIM: 139340,613856) PREDICTED: guanine (354 aa) initn: 1908 init1: 1908 opt: 1937 Z-score: 2339.4 bits: 441.4 E(85289): 1.4e-123 Smith-Waterman score: 1937; 81.9% identity (94.6% similar) in 354 aa overlap (1-350:1-354) 10 20 30 40 50 pF1KE3 MGAGASAEEKH----SRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDG ::.:::::.:. :.::::::.:::.:.:.:::::::::::::::::::::::::::: XP_011 MGSGASAEDKELAKRSKELEKKLQEDADKEAKTVKLLLLGAGESGKSTIVKQMKIIHQDG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 YSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMP :: :::::: ::::::.:::::::.::::::.:.:.. . ::.:.: ..::.::::::: XP_011 YSPEECLEFKAIIYGNVLQSILAIIRAMTTLGIDYAEPSCADDGRQLNNLADSIEEGTMP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 KEMSDIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVK :. ..:.:::::.:.:::::::.::::::::.:::..:::.. : :.:.:::::::::: XP_011 PELVEVIRRLWKDGGVQACFERAAEYQLNDSASYYLNQLERITDPEYLPSEQDVLRSRVK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 TTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEV :::::::.:: :::::::::::::::::::::::::::::::: :::::::::::::::: XP_011 TTGIIETKFSVKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDDEV 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 NRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAG ::::::::::::::::..::.:::::::::::.: :::::.:::::::.::: :.:.::: XP_011 NRMHESLHLFNSICNHKFFAATSIVLFLNKKDLFEEKIKKVHLSICFPEYDGNNSYDDAG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 NYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF :::: :::.::::.:::::::::::::::::::::::::::::::::::::::: XP_011 NYIKSQFLDLNMRKDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF 310 320 330 340 350 >>NP_005263 (OMIM: 139340,613856) guanine nucleotide-bin (354 aa) initn: 1908 init1: 1908 opt: 1937 Z-score: 2339.4 bits: 441.4 E(85289): 1.4e-123 Smith-Waterman score: 1937; 81.9% identity (94.6% similar) in 354 aa overlap (1-350:1-354) 10 20 30 40 50 pF1KE3 MGAGASAEEKH----SRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDG ::.:::::.:. :.::::::.:::.:.:.:::::::::::::::::::::::::::: NP_005 MGSGASAEDKELAKRSKELEKKLQEDADKEAKTVKLLLLGAGESGKSTIVKQMKIIHQDG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 YSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMP :: :::::: ::::::.:::::::.::::::.:.:.. . ::.:.: ..::.::::::: NP_005 YSPEECLEFKAIIYGNVLQSILAIIRAMTTLGIDYAEPSCADDGRQLNNLADSIEEGTMP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 KEMSDIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVK :. ..:.:::::.:.:::::::.::::::::.:::..:::.. : :.:.:::::::::: NP_005 PELVEVIRRLWKDGGVQACFERAAEYQLNDSASYYLNQLERITDPEYLPSEQDVLRSRVK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 TTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEV :::::::.:: :::::::::::::::::::::::::::::::: :::::::::::::::: NP_005 TTGIIETKFSVKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDDEV 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 NRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAG ::::::::::::::::..::.:::::::::::.: :::::.:::::::.::: :.:.::: NP_005 NRMHESLHLFNSICNHKFFAATSIVLFLNKKDLFEEKIKKVHLSICFPEYDGNNSYDDAG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 NYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF :::: :::.::::.:::::::::::::::::::::::::::::::::::::::: NP_005 NYIKSQFLDLNMRKDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF 310 320 330 340 350 >>NP_001095856 (OMIM: 139395) guanine nucleotide-binding (354 aa) initn: 1844 init1: 1844 opt: 1860 Z-score: 2246.6 bits: 424.2 E(85289): 2.1e-118 Smith-Waterman score: 1860; 78.2% identity (92.7% similar) in 354 aa overlap (1-350:1-354) 10 20 30 40 50 pF1KE3 MGAGASAEEKHS----RELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDG ::.: :.: :.: .::::::.::::.::::::::::::::::::::::::::::..: NP_001 MGSGISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 YSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMP :: .::.:: :.::.::::::::::.:::::.:.: . .: :.:. ::.:.:.: : NP_001 YSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLEDGGMT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 KEMSDIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVK .....:.:::.: ::::::::::::::::::.:::.::.:... ::::.:::::.:::: NP_001 PQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 TTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEV ::::::::::::::.:::::::::::::::::::::::::::: :::::::::::::.:: NP_001 TTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEV 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 NRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAG ::::::::::::::::.::.::::::::::::.: ::. :.:::::::.: ::::.:::: NP_001 NRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNTFEDAG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 NYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF :::: :::.::.... :::::::::::::::::::::::::::::::::::::: NP_001 NYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF 310 320 330 340 350 >>NP_002060 (OMIM: 139310) guanine nucleotide-binding pr (354 aa) initn: 1639 init1: 1639 opt: 1653 Z-score: 1997.1 bits: 378.0 E(85289): 1.7e-104 Smith-Waterman score: 1653; 67.8% identity (89.3% similar) in 354 aa overlap (1-350:1-354) 10 20 30 40 50 pF1KE3 MGAGASAEEK----HSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDG :: :::.: .:. ....:.::.:: :: ::::::::::::::::::::::::. : NP_002 MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 YSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMP :: ::: .. :..:.::.:::.::.::: :.:..::::: ::::.:. .: . ::: : NP_002 YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 KEMSDIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVK :.. .:.:::::::.::::.:. ::::::::.:::.::.:.. :.:.::.:::::.::: NP_002 AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 TTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEV ::::.::.:.::::.:.:::::::::::::::::::::: ::: .::: ::.::.::.:. NP_002 TTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 NRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAG ::::::..::.::::...:. :::.:::::::.: :::::. :.::.:.: : ::::.:. NP_002 NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 NYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF ::. :: .:: :.:.::::.:.::::::.::.::::::::.:::.:::::::: NP_002 AYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF 310 320 330 340 350 >>NP_006487 (OMIM: 139370,602483) guanine nucleotide-bin (354 aa) initn: 1624 init1: 1570 opt: 1607 Z-score: 1941.6 bits: 367.8 E(85289): 2.1e-101 Smith-Waterman score: 1607; 65.0% identity (88.7% similar) in 354 aa overlap (1-350:1-354) 10 20 30 40 50 pF1KE3 MGAGASAEEK----HSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDG :: :::.: .:. ....:.::.:: :. ::::::::::::::::::::::::.:: NP_006 MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 YSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMP :: .:: .. ...:.::.:::.::.::: :.:..:..:: ::::.:. .: . :::.: NP_006 YSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAGSAEEGVMT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 KEMSDIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVK :.. .:.:::.:.:.:::: :. ::::::::.:::.::.:. .:.::.:::::.::: NP_006 PELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQSNYIPTQQDVLRTRVK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 TTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEV ::::.::.:.:::: :.:::::::::::::::::::::: ::: .::: ::.::.::.:. NP_006 TTGIVETHFTFKDLYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 NRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAG ::::::..::.::::...:. :::.:::::::.: ::::.. :.::.:.: : ::::.:. NP_006 NRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 NYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF ::. :: .:: :.:.::::.:.::::::.::.::::::::.:::.:::.:::. NP_006 AYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY 310 320 330 340 350 >>NP_002061 (OMIM: 139360,192605) guanine nucleotide-bin (355 aa) initn: 1193 init1: 1193 opt: 1605 Z-score: 1939.2 bits: 367.3 E(85289): 2.8e-101 Smith-Waterman score: 1605; 65.9% identity (88.7% similar) in 355 aa overlap (1-350:1-355) 10 20 30 40 50 pF1KE3 MGAGASAEEK----HSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDG :: .:::.: .:. ..:.:.::.:: :: ::::::::::::::::::::::::.:: NP_002 MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 YSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEE-GTM :: ::: .. :..:.::.:::.:::.:: .:.:...: .: ::::.:. .. : :: :.. NP_002 YSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 PKEMSDIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRV : ..: .:.::: : :.:::: :. ::::::::.:::.::::.. :.::.:::::.:: NP_002 PDDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 KTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDE :::::.::.:.::::.:.:::::::::::::::::::::: ::: .::::::.::.::.: NP_002 KTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 VNRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDA .::::::..::.::::...:. :::.:::::::.: ::: .. :.::::.: : : :..: NP_002 MNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 GNYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF ..::. .: .:: :.:.::::.:.::::::.::.::::::::.:::.:::::::: NP_002 ASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF 310 320 330 340 350 >>NP_001159897 (OMIM: 139360,192605) guanine nucleotide- (318 aa) initn: 1193 init1: 1193 opt: 1497 Z-score: 1809.7 bits: 343.2 E(85289): 4.6e-94 Smith-Waterman score: 1497; 67.4% identity (90.2% similar) in 316 aa overlap (36-350:3-318) 10 20 30 40 50 60 pF1KE3 SAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEF ::::::::::::::::::.:::: ::: .. NP_001 MRGAGESGKSTIVKQMKIIHEDGYSEEECRQY 10 20 30 70 80 90 100 110 120 pF1KE3 IAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEE-GTMPKEMSDIIQ :..:.::.:::.:::.:: .:.:...: .: ::::.:. .. : :: :..: ..: .:. NP_001 RAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPDDLSGVIR 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 RLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQ ::: : :.:::: :. ::::::::.:::.::::.. :.::.:::::.:::::::.::. NP_001 RLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETH 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE3 FSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMHESLH :.::::.:.:::::::::::::::::::::: ::: .::::::.::.::.:.::::::.. NP_001 FTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMK 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE3 LFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAGNYIKVQFL ::.::::...:. :::.:::::::.: ::: .. :.::::.: : : :..:..::. .: NP_001 LFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEAASYIQSKFE 220 230 240 250 260 270 310 320 330 340 350 pF1KE3 ELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF .:: :.:.::::.:.::::::.::.::::::::.:::.:::::::: NP_001 DLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF 280 290 300 310 >>NP_001269549 (OMIM: 139360,192605) guanine nucleotide- (339 aa) initn: 1193 init1: 1193 opt: 1497 Z-score: 1809.3 bits: 343.2 E(85289): 4.9e-94 Smith-Waterman score: 1497; 67.4% identity (90.2% similar) in 316 aa overlap (36-350:24-339) 10 20 30 40 50 60 pF1KE3 SAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEF ::::::::::::::::::.:::: ::: .. NP_001 MTEGVKTLGWTKQKGGCHWGRSEGAGESGKSTIVKQMKIIHEDGYSEEECRQY 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 IAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEE-GTMPKEMSDIIQ :..:.::.:::.:::.:: .:.:...: .: ::::.:. .. : :: :..: ..: .:. NP_001 RAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPDDLSGVIR 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 RLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQ ::: : :.:::: :. ::::::::.:::.::::.. :.::.:::::.:::::::.::. NP_001 RLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETH 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 FSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMHESLH :.::::.:.:::::::::::::::::::::: ::: .::::::.::.::.:.::::::.. NP_001 FTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMK 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 LFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAGNYIKVQFL ::.::::...:. :::.:::::::.: ::: .. :.::::.: : : :..:..::. .: NP_001 LFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEAASYIQSKFE 240 250 260 270 280 290 310 320 330 340 350 pF1KE3 ELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF .:: :.:.::::.:.::::::.::.::::::::.:::.:::::::: NP_001 DLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF 300 310 320 330 350 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 22:51:50 2016 done: Sat Nov 5 22:51:51 2016 Total Scan time: 7.360 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]